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C M White, M K Hanna
OBJECTIVE: The glans penis may show a deep groove (surgically favorable), or may appear flat with an absent sulcus (unfavorable). Glans dehiscence following hypospadias repair, especially after multiple surgeries, frequently results in a scarred, obliterated, or absent urethral plate. The glans penis appears to be flat and grooveless. This study reported on the outcome of a two-stage salvage repair for glans dehiscence in 49 consecutive patients. MATERIALS AND METHODS: Retrospective chart review was performed for all patients who underwent repair for glans dehiscence following hypospadias repair...
May 30, 2018: Journal of Pediatric Urology
Marek Switonski, Stanislaw Dzimira, Roman Aleksiewicz, Izabela Szczerbal, Joanna Nowacka-Woszuk, Paulina Krzeminska, Tomasz Deska, Wojciech Nizanski
Hypospadias, the abnormal position of the urethral orifice, is considered a rare congenital malformation of the reproductive organs in male dogs. We present 5 new cases of hypospadias - 2 of the penile type in German Shepherd Dogs and 3 perineal types in a Bavarian Mountain Hound, a French Bulldog, and an American Staffordshire Terrier. Other abnormalities (rudimentary or underdeveloped penis, incompletely formed preputial sheath, and bilateral cryptorchidism) were also observed. Molecular analysis of all cases revealed the presence of Y-linked genes (SRY and ZFY)...
June 13, 2018: Sexual Development: Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
D A Weiss, C J Long, J R Frazier, A R Shukla, A K Srinivasan, T F Kolon, H DiCarlo, J P Gearhart, D A Canning
INTRODUCTION: Re-operative penile reconstruction is challenging and requires tension-free skin closure. The repair popularized by Cecil and Culp in the 1940s, using the scrotum to provide a temporary vascularized bed for complex hypospadias repairs, fell out of favor due to temporal trends towards single-stage repairs and concern for utilizing hair-bearing skin on the penile shaft. OBJECTIVE: It was hypothesized that a modified Cecil-Culp (CC) concept of penile scrotalization, leaving the penis attached to the scrotum for 1 year rather than 6 weeks as originally described, improves outcomes with this reconstruction for ventral skin deficiency or poor vascular support...
May 30, 2018: Journal of Pediatric Urology
Luiz G Freitas Filho, José Carnevale, Mila T C Leite, Francisco Kanasiro, Luiz J Budib
No abstract text is available yet for this article.
July 2018: Urology Case Reports
Megumi Hatano, Ryuji Fukuzawa, Yukihiro Hasegawa
Some patients with mixed gonadal dysgenesis (MGD), whose prototypical karyotype is 45,X/46,XY, are known to manifest complications characteristic of Turner syndrome. We report a 16-year-old social male with MGD presenting with coarctation of the aorta, one of the common complications for Turner syndrome. At birth, the patient was found to have hypospadias, bifid scrotum, and cryptorchidism. Chromosomal analysis of his lymphocytes revealed the karyotype 45,X[7]/46,X,dic(Y;22)(p11.3;q13.3)[23] (named 45,X/46,X+Y fragment in this article)...
June 8, 2018: Sexual Development: Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
Smail Acimi
No abstract text is available yet for this article.
2018: Frontiers in Pediatrics
Kimihiko Moriya
No abstract text is available yet for this article.
June 3, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
Pierre Pescheloche, Benoit Parmentier, Thevy Hor, Olivier Chamond, Maud Chabaud, Sabine Irtan, Georges Audry
INTRODUCTION: Fistulas are a common complication of hypospadias surgery; they are more frequent after mid-shaft and posterior hypospadias repair. Surgical treatment of fistula still remains challenging with a significant failure rate. The basic principle is to add layers between skin and neourethra in order to decrease the incidence of recurrent urethrocutaneous fistula (UCF). We report our experience of UCF repair using a vascularized tunica vaginalis flap (TVF) after posterior and mid-shaft hypospadias surgery...
May 21, 2018: Journal of Pediatric Urology
Ge Liu, Xin Liu, Joel Shen, Adriane Sinclair, Laurence Baskin, Gerald R Cunha
This paper addresses the developmental mechanisms of formation of the mouse and human penile urethra and the possibility that two disparate mechanisms are at play. It has been suggested that the entire penile urethra of the mouse forms via direct canalization of the endodermal urethral plate. While this mechanism surely accounts for development of the proximal portion of the mouse penile urethra, we suggest that the distal portion of the mouse penile urethra forms via a series of epithelial fusion events. Through review of the recent literature in combination with new data, it is unlikely that the entire mouse urethra is formed from the endodermal urethral plate due in part to the fact that from E14 onward the urethral plate is not present in the distal aspect of the genital tubercle...
May 2018: Differentiation; Research in Biological Diversity
Farshid Alizadeh, Seyed Morteza Heydari, Reza Nejadgashti
BACKGROUND: Intraoperative blood loss is considered to be an important issue in hypospadias surgery. Some studies have demonstrated the utility of caudal epidural block (CEB) in this regard among pediatric patients with hypospadias. Though there is evidence in favor of the use of CEB as the only anesthetic method for pediatric surgeries, it is usually used in combination with general anesthesia. In this form of use, it could have more favorable outcomes for both intra- and postoperative periods...
May 21, 2018: Journal of Pediatric Urology
Jin K Kim, Michael E Chua, Jessica M Ming, Luis H Braga, Grahame H H Smith, Christopher Driver, Martin A Koyle
INTRODUCTION AND BACKGROUND: Although there is abundance in literature focusing on the use of prophylactic antibiotics for adult urological procedures, the evidence for using antibiotics following common pediatric urological procedures is limited with no specific guidelines for use. Consequently, current practices on antibiotic usage for common interventions may be variable among practicing pediatric urologists, lacking evidence-based support. OBJECTIVE: The aim was to evaluate the current practice pattern on antibiotic usage for common interventions amongst pediatric urologists (PU) practicing in four English-speaking sectors of the world...
May 19, 2018: Journal of Pediatric Urology
Michiko Nakamura, Kimihiko Moriya, Yoko Nishimura, Mutsumi Nishida, Yusuke Kudo, Yukiko Kanno, Takeya Kitta, Masafumi Kon, Nobuo Shinohara
BACKGROUND: It has been described that the incidence of testicular microlithiasis is high in several congenital disorders which may be associated with testicular impairment and infertility. Several reports have shown that a prepubertal or pubertal hormonal abnormality in the pituitary-gonadal axis was identified in some patients with hypospadias that is one of the most common disorders of sex development. However, exact prevalence or risk factors of testicular microlithiasis in patients with hypospadias have not reported so far...
May 29, 2018: BMC Pediatrics
Y S Wong, K K Pang, Y H Tam
INTRODUCTION: Children in Hong Kong are generally hospitalised for 1 to 2 weeks after hypospadias repairs. In July 2013, we introduced a new service model that featured an enhanced recovery pathway and a dedicated surgical team responsible for all perioperative services. In this study, we investigated the outcomes of hypospadias repair after the introduction of the new service model. METHODS: We conducted a retrospective study on consecutive children who underwent primary hypospadias repair from January 2006 to August 2016, comparing patients under the old service with those under the new service...
May 21, 2018: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
Bing Liu, Di Wang, Zhe Yang, Yong Tang, Yangqun Li, Wen Chen
Objective: To present method and experiences in using the buccal mucosa with the Snodgrass procedure for repair of hypospadias. Methods: Between August 2012 and April 2015, 55 boys with hypospadias were treated with Snodgrass procedure combined with buccal mucosa. The age ranged from 1 to 7 years (mean, 4 years). There were 32 cases of distal penile type, 14 cases of proximal penile type, and 9 cases of coronal sulcus type. The buccal mucosa taking from inner cheek was fixed into the incised urethral plate...
January 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
S K Maiti, P D S Raghuvanshi, M Divya, P Sangeetha, G Deepesh, K Naveen
A 40 kg crossbred calf of one month age was presented to the Institute Referral Polyclinic, with a history of dysuria, stranguria along with a fluctuant swelling in the mid-perineal region. On physical examination, a diverticulum was observed which on aspiration revealed urine. It was reported that urine outflow was from a tiny orifice at the proposed natural site of the vulva. Dissection of the skin over the diverticulum revealed hypoplastic penis with adhesion of the preputeal sheath along with penile hypospadia...
2018: Iranian Journal of Veterinary Research
Rabea G Omar, Mostafa M Khalil, Hammouda Sherif, Hesham Elezaby
OBJECTIVE: To use the prepuce for double functions one as a second layer for the neourethra to decrease the incidence of urethrocutaneous fistula and the second as a skin covering for the ventral aspect of the penis. MATERIAL AND METHODS: From January 2013 to December 2016, 37 cases of hypospadias with mild to moderate chordee were included in this study. The cases with ventral penile skin defect were managed by tubularized incised plate urethroplasty (TIPU) using pedicled preputial flap...
March 16, 2018: Turkish Journal of Urology
Smail Acimi
OBJECTIVE: To report the information concerning the pathogenesis of proximal hypospadias and causes of curvature associated with it. MATERIAL AND METHODS: From January 2009 to December 2015, 74 patients underwent repair of proximal hypospadias. In 70 patients we performed a systematic biopsies in the lateral areas of the urethral plate, as well as under this plate. The study of the histological structure of these areas was performed using routine staining with hematoxylin and eosin (H&E), and the Masson's trichrome which color the collagen fibers in blue and monoclonal antibody against alpha-smooth muscle actin...
March 6, 2018: Turkish Journal of Urology
Douglas A Canning
No abstract text is available yet for this article.
June 2018: Journal of Urology
Elizabeth B Roth, John V Kryger, Charles T Durkee, Melissa A Lingongo, Ruth M Swedler, Travis W Groth
Purpose: To evaluate the impact of prophylactic antibiotics after distal hypospadias repair on postoperative bacteriuria, symptomatic urinary tract infection, and postoperative complications in a prospective, randomized trial. Materials and Methods: Consecutive patients aged 6 months to 2 years were enrolled at our institution between June 2013 and May 2017. Consenting patients were randomized to antibiotic prophylaxis with trimethoprim-sulfamethoxazole versus no antibiotic...
2018: Advances in Urology
Yu Chen, Hongshi Yu, Andrew J Pask, Asao Fujiyama, Yutaka Suzuki, Sumio Sugano, Geoff Shaw, Marilyn B Renfree
Environmental endocrine disruptors (EEDs) that affect androgen or estrogen activity may disrupt gene regulation during normal phallus development to cause hypospadias or a masculinized clitoris. We treated developing male tammar wallabies with estrogen and females with androgen from day 20-40 postpartum (pp) during the established androgen imprinting window. Administration of estrogen to males inhibited phallus elongation but had no effect on urethral closure and did not significantly depress testicular androgen synthesis...
May 14, 2018: Biology of Reproduction
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