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Hypospadia

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https://www.readbyqxmd.com/read/28436366/analysis-of-preoperative-antibiotic-prophylaxis-in-stented-distal-hypospadias-repair
#1
Jacob Smith, Ashay Patel, Ismael Zamilpa, Shasha Bai, Jeffrey Alliston, Stephen Canon
INTRODUCTION: Surgical site infection [SSI] is a risk for any surgical procedure, including hypospadias repair. Prophylactic antibiotic therapy for patients having surgery is often effective in preventing SSIs, but with increasing rates of antibiotic resistance, this practice has been questioned. The objectives of this study are 1) to assess the incidence of SSIs in patients following stented, distal hypospadias repair and 2) to observe for any potential difference in the incidence of SSIs for patients with and without preoperative antibiotic utilization in this setting...
April 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/28434637/clinical-heterogeneity-in-children-with-gonadal-dysgenesis-associated-with-non-mosaic-46-xy-karyotype
#2
Y S Wong, Y H Tam, K K Y Pang, K F To, S S C Chan, K W Chan, K H Lee
INTRODUCTION: Gonadal dysgenesis is unique in disorders of sex development (DSD), in that it can be associated with 46,XX, 46,XY or mosaic 45,X/46,XY karyotypes. Gonadal dysgenesis can be partial or complete. Gonadal dysgenesis associated with the Y-chromosome has increased risk of gonadal germ cell neoplasms. Most of the literature focus on 45,X/46,XY gonadal dysgenesis, while there are scanty data on the condition when the karyotype is non-mosaic 46,XY. OBJECTIVE: To investigate the diversity of clinical pictures of children presenting with 46,XY DSD due to gonadal dysgenesis...
April 10, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28434634/hypospadias-surgery-in-england-higher-volume-centres-have-lower-complication-rates
#3
David J Wilkinson, Patrick A Green, Shanthi Beglinger, Jessica Myers, Rachel Hudson, David Edgar, Simon E Kenny
INTRODUCTION: Hypospadias surgery has progressed steadily over recent years. There remains considerable variation in the operative management of boys with hypospadias in the UK, and it is therefore difficult to identify acceptable standards with regards to reoperation rates. OBJECTIVE: To determine the frequency of reoperations and complications from all centres performing hypospadias surgery in England and to identify variables that influence outcome. METHODS: All children undergoing NHS hypospadias surgery in England between 1999 and 2009 were identified using the Hospital Episode Statistics database...
February 20, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28434633/echocardiographic-evaluation-of-left-ventricular-mass-index-in-children-with-hypospadias-after-hormonal-stimulation-with-topical-testosterone-a-randomized-controlled-trial
#4
Elisabeth Campos de Andrade, Kelly Christina de Castro Paiva, Sarah da Silva Guedes, Mariana Lima C Souza, Marina Novellino Pereira, Laura Pimenta Miana, André Avarese de Figueiredo, José de Bessa, José Murillo B Netto
INTRODUCTION: Testosterone is often used in the preoperative period of hypospadias surgery. Previous studies have demonstrated the presence of androgen receptors in cardiac myocytes that can modulate the phenotype. The use of supraphysiological doses of androgens can lead to toxicity on the heart muscle and, in some cases, to left ventricular hypertrophy. This randomized double blind controlled clinical trial aims to evaluate the effect of topical testosterone on left ventricular mass index in boys with hypospadias...
April 10, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28432720/androgen-receptor-dysfunction-as-a-prevalent-manifestation-in-young-male-carriers-of-a-flna-gene-mutation
#5
Laura Carrera-García, Maximiliano Francisco Rivas-Crespo, María Soledad Fernández García
Androgenic actions require the proper signal transmission by the androgen receptor (AR), a nuclear transcription factor. This is initially located in the cell cytoplasm and should translocates to the nucleus to interact with DNA. AR functional impairment causes diverse blockage degrees of androgenic steroid action, known as androgen insensitivity syndromes. Filamin A, a protein coded by the FLNA gene, is a co-activator of various cytoplasmic factors, including AR. The mutational inactivation of the FLNA gene induces insufficiency of translocation and activation of AR...
April 21, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28429283/use-of-hormones-tissue-factors-and-bioengineering-in-the-management-of-hypospadias
#6
Aparajita Mitra, Yogesh Kumar Sarin
Hypospadiology is a rapidly evolving field. Progress in the understanding of how hormonal therapy affects the growth of the phallus has allowed surgeons to optimize the tissues for surgery. But conflicting data from a number of studies and a lack of consensus on drugs, their dosing, mode of delivery and timing of use means that the creation of protocols is unlikely to happen in the near future. Nonetheless, there is a hope and the standardization of scientific reporting will make it easier to compare data at the global level...
April 21, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28400187/staged-tubularized-auto-graft-stag-repair-for-primary-proximal-hypospadias-with-%C3%A2-30%C3%A2-ventral-curvature
#7
Warren Snodgrass, Nicol Bush
PURPOSE: We report outcomes in consecutive patients with primary proximal hypospadias and ventral curvature≥ 30° after degloving, all repaired by 2-stage tubularized autografts (STAG), a variation of the Nicolle-Bracka procedure. MATERIALS AND METHODS: Consecutive boys with proximal hypospadias and ventral curvature (VC) ≥ 30° after degloving all underwent transection of the urethral plate. Those with persistent VC ≥ 30° additionally had 3 ventral corporotomies without corporal grafting for straightening...
April 8, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28398666/association-between-a-maternal-history-of-miscarriages-and-birth-defects
#8
Hebe Campaña, Monica Rittler, Juan A Gili, Fernando A Poletta, Mariela S Pawluk, Lucas G Gimenez, Viviana R Cosentino, Eduardo E Castilla, Jorge S López Camelo
BACKGROUND: Some studies, mainly in the older literature, observed a significant association between miscarriages and birth defects (BDs) occurring in the same sibship. However, few studies examined the BD/miscarriage relationship in depth. In addition nothing has been added to the underlying mechanisms possibly linking both events. The purpose of this work was to identify specific BDs associated with maternal miscarriages. In particular, it examined whether the risk depended on the number of losses, and to suggest the existence of specific factors for each BD/miscarriage association observed...
March 1, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28398663/early-childhood-development-of-boys-with-genital-anomalies
#9
Francisco J Schneuer, Jason P Bentley, Andrew J A Holland, Samantha J Lain, Sarra E Jamieson, Nadia Badawi, Natasha Nassar
BACKGROUND: Male genital anomalies often require surgery in early life to address functional and cosmetic consequences. However, there has been little assessment of developmental outcomes of affected boys. METHODS: We conducted a population-based cohort study of all boys born in New South Wales, Australia, and undergoing school-entry developmental assessment in 2009 or 2012. Health and developmental information was obtained by means of record-linkage of birth, hospital and Australian Early Development Census data...
March 31, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28397209/-karyotyping-and-analysis-of-5%C3%AE-reductase-2-gene-mutation-in-25-patients-with-hypospadias
#10
Shimin Yuan, Changgao Zhong, Xiurong Li, Juan Du, Wen Li, Guangxiu Lu, Yueqiu Tan
OBJECTIVE: To analyze the karyotypes and SRD5A2 gene mutations in 25 patients with sporadic or familial hypospadias. METHODS: The patients included 10 adults and 15 children, whose chromosomes were analyzed by G-banded karyotyping, and the SRD5A2 genes were sequenced. RESULTS: Two patients were found to have an abnormal karyotype, while eight have carried compound heterozygous mutations of the SRD5A2 gene, which included 5 genotypes formed by 6 types of mutations, i...
April 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/28389178/ultrasound-diagnosis-of-fetal-hypospadias-accuracy-and-outcomes
#11
Yan Epelboym, Carlos Estrada, Judy Estroff
OBJECTIVES: The purpose of this study was to assess the positive predictive value of a prenatal ultrasound diagnosis of hypospadias when compared with postnatal diagnosis based on physical exam. METHODS: We retrospectively identified all pregnant women between 2004 and 2014 who were either referred to our fetal care center carrying a fetus with an ultrasound diagnosis of possible hypospadias or who had a new diagnosis of hypospadias after imaging in our center. RESULTS: A total of 32 cases of possible hypospadias were identified, with our fetal center ultrasound suggesting hypospadias in 25 of the 32 cases (78%)...
March 24, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28384289/psychosocial-outcomes-in-adult-men-born-with-hypospadias-a-register-based-study
#12
Anna Skarin Nordenvall, Christina Norrby, Agnieszka Butwicka, Louise Frisén, Anna Nordenström, Catarina Almqvist, Agneta Nordenskjöld
In this nationwide matched cohort study, we have investigated whether being born with hypospadias affect subsequent psychosocial outcomes in adulthood. We analyzed prospectively collected data from national Swedish registers. Data on the diagnoses were collected from the National Patient Register and the Medical Birth Register. Data on psychosocial outcomes such as educational and income level, marital status and disability pension were collected from Statistics Sweden. The effects of covariates, such as age, county of birth, presence of other malformations and psychiatric illness, were taken into account...
2017: PloS One
https://www.readbyqxmd.com/read/28359778/one-stage-repair-of-proximal-hypospadias-with-severe-chordee-by-in-situ-tubularization-of-the-transverse-preputial-island-flap
#13
Yichen Huang, Hua Xie, Yiqing Lv, Ling Yu, Li Sun, Xiaoxi Li, Yan Chen, Huizhen Sun, Fang Chen
INTRODUCTION: To investigate a modified transverse preputial island flap repair which is performed in an attempt to reduce the complications following one-stage repair of proximal hypospadias with chordee. METHODS: Briefly, the two ends of the flap were trimmed into V shape and anastomosed with the spatulated urethra proximally and urethral plate distally before tubularization. Then the in situ tubularization of the flap was performed. The procedure was performed in our hospital on 32 patients (mean age = 11 months)...
March 16, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28352662/experimentally-induced-testicular-dysgenesis-syndrome-originates-in-the-masculinization-programming-window
#14
Sander van den Driesche, Karen R Kilcoyne, Ida Wagner, Diane Rebourcet, Ashley Boyle, Rod Mitchell, Chris McKinnell, Sheila Macpherson, Roland Donat, Chitranjan J Shukla, Anne Jorgensen, Ewa Rajpert-De Meyts, Niels E Skakkebaek, Richard M Sharpe
The testicular dysgenesis syndrome (TDS) hypothesis, which proposes that common reproductive disorders of newborn and adult human males may have a common fetal origin, is largely untested. We tested this hypothesis using a rat model involving gestational exposure to dibutyl phthalate (DBP), which suppresses testosterone production by the fetal testis. We evaluated if induction of TDS via testosterone suppression is restricted to the "masculinization programming window" (MPW), as indicated by reduction in anogenital distance (AGD)...
March 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28351651/a-population-based-study-of-prevalence-trends-and-geospatial-analysis-of-hypospadias-and-cryptorchidism-compared-with-non-endocrine-mediated-congenital-anomalies
#15
Ciaran Lane, James Boxall, Dawn MacLellan, Peter A Anderson, Linda Dodds, Rodrigo L P Romao
INTRODUCTION: Several reports have suggested an increase in the prevalence of hypospadias and cryptorchidism over the last few decades. Endocrine disruption caused by exposure to environmental chemicals has been postulated as a possible cause. OBJECTIVES: The objectives of our study were: 1) to determine whether the prevalence of hypospadias and cryptorchidism is increasing compared with other congenital anomalies not known to be mediated by endocrine factors; and 2) to perform a geospatial analysis of these congenital malformations looking for clustering that could offer insight into environmental risk factors...
March 14, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28351650/in-pursuit-of-the-perfect-penis-hypospadias-repair-outcomes
#16
EDITORIAL
Brenton B Winship, H Gil Rushton, Hans G Pohl
Hypospadias is commonly assessed and repaired by pediatric urologists. Mild, distal hypospadias is generally more a cosmetic problem than a functional one and is more frequently encountered than severe, proximal hypospadias. Outcomes following repair, especially of mild phenotypes, are important to understand, but range widely in timing and measurability. Surgical complications, postoperative satisfaction of parents, patients, surgeons and even lay observers, urinary function, sexual function, and quality of life all may be considered as relevant outcomes of hypospadias repair...
March 15, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28351396/evaluation-and-treatment-for-ovotesticular-disorder-of-sex-development-ot-dsd-experience-based-on-a-chinese-series
#17
Yu Mao, Shaoji Chen, Ru Wang, Xuejun Wang, Daorui Qin, Yunman Tang
BACKGROUND: The aim of this study is to review and present the clinical features and process of evaluation and treatment for OT-DSD in a single center in recent years in China. METHODS: Sixteen patients with OT-DSD during the past 4 years underwent the evaluation and treatment in a single center. The clinical characteristics and outcomes of surgery were analyzed. RESULTS: The surgical age ranged from 17 months to 66 months with a mean age of 20 months, and the mean follow-up was 30 months (4 months to 56 months)...
March 28, 2017: BMC Urology
https://www.readbyqxmd.com/read/28345802/the-association-between-caudal-anesthesia-and-increased-risk-of-postoperative-surgical-complications-in-boys-undergoing-hypospadias-repair
#18
Brad M Taicher, Jonathan C Routh, John B Eck, Sherry S Ross, John S Wiener, Allison K Ross
INTRODUCTION: Recent reports have suggested that caudal anesthesia may be associated with an increased risk of postoperative surgical complications. We examined our experience with caudal anesthesia in hypospadias repair to evaluate for increased risk of urethrocutaneous fistula or glanular dehiscence. METHODS: All hypospadias repairs performed by a single surgeon in 2001-2014 were reviewed. Staged or revision surgeries were excluded. Patient age, weight, hypospadias severity, surgery duration, month and year of surgery, caudal anesthesia use, and postoperative complications were recorded...
March 27, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28344020/the-incidence-of-isolated-penile-torsion-in-north-india-a-study-of-5-018-male-neonates
#19
Amilal Bhat, Mahakshit Bhat, Vinay Kumar, Suresh Goyal, Akshita Bhat, Madhu Patni
OBJECTIVE: Congenital penile torsion is a three-dimensional deformity with helical rotation of the distal corporal bodies with the penile crurae remaining fixed to the pubic rami. The first case of congenital penile torsion (hypospadias) was described in 1857. Isolated penile torsion is an under-reported anomaly. The reported incidence of isolated penile torsion is 1.7-27% and severe torsion is 0.7%. There are no studies available from Indian subcontinent on the incidence of isolated penile torque...
March 1, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28341425/proximal-hypospadias-repair-with-bladder-mucosal-graft-our-10-years-experience
#20
Michele Lanciotti, Marta Betti, Antonio Elia, Luca Landi, Maria Taverna, Chiara Cini, Lorenzo Masieri
INTRODUCTION AND OBJECTIVE: A great variety of different surgical techniques has been described for proximal hypospadias repair and an ideal tissue has not been determined yet. We present our 10 years of surgical experience using a bladder mucosal graft for urethroplasty. STUDY DESIGN: Bladder mucosal graft urethroplasty was performed between 2005 and 2015 in 50 patients with severe proximal hypospadias. The mean age of patients was 45.1 months (range 24-164 months)...
February 17, 2017: Journal of Pediatric Urology
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