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Hypospadia

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https://www.readbyqxmd.com/read/27900221/grafted-tubularised-incised-plate-urethroplasty-an-objective-assessment-of-outcome-with-lessons-learnt-from-surgical-experience-with-263-cases
#1
Vipul Gupta, Sunil Kumar Yadav, Talal Alanzi, Islam Amer, Mohmmad Salah, Mamdouh Ahmed
OBJECTIVE: Snodgrass urethroplasty remains the preferred technique in primary distal hypospadias but development of meatal stenosis often limits distal extension of the midline incision of the urethral plate (MIUP), which remains a limiting factor in reconstructing an apical neomeatus (NM). We here-in assess the cosmetic and functional outcome with distal extension of the MIUP in grafted tubularised incised-plate urethroplasty (G-TIP) repair. PATIENTS AND METHODS: This prospective study included the surgical experience of 263 cases of primary hypospadias operated upon between 2012 and 2015...
December 2016: Arab Journal of Urology
https://www.readbyqxmd.com/read/27899089/familial-forms-of-disorders-of-sex-development-may-be-common-if-infertility-is-considered-a-comorbidity
#2
Raja Brauner, Flavia Picard-Dieval, Henri Lottmann, Sébastien Rouget, Joelle Bignon-Topalovic, Anu Bashamboo, Ken McElreavey
BACKGROUND: Families with 46,XY Disorders of Sex Development (DSD) have been reported, but they are considered to be exceptionally rare, with the exception of the familial forms of disorders affecting androgen synthesis or action. The families of some patients with anorchia may include individuals with 46,XY gonadal dysgenesis. We therefore analysed a large series of patients with 46,XY DSD or anorchia for the occurrence in their family of one of these phenotypes and/or ovarian insufficiency and/or infertility and/or cryptorchidism...
November 29, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27889218/single-stage-urethroplasty-for-perineal-hypospadias-in-a-horse-a-case-report
#3
Jade Harrison, Imran Mushtaq
INTRODUCTION: Within the veterinary world, data regarding the surgical management of hypospadias is lacking. Reports within equines have documented resective phallectomy procedures rather than urethral reconstruction. This case report documents the first ever urethroplasty for an equine hypospadias, performed by a consultant paediatric surgeon. The urethroplasty was achieved by applying the same surgical principles mastered from paediatric urology to a horse. The indication for surgery was contact dermatitis of the hind-leg, which impaired the thoroughbred foal's racing potential...
November 9, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27889217/the-sight-questionnaire-a-novel-assessment-tool-for-satisfaction-in-genital-hypospadias-treatment
#4
Peter U Ardelt, Marco Cederqvist, Michael Barth, Alexander Frankenschmidt
PURPOSE: Psychosexual development is currently underrepresented in hypospadias outcome research. The aim of this study was to develop and validate a questionnaire addressing psychosexual long-term satisfaction, specifically of adolescent patients, after hypospadias repair. MATERIALS AND METHODS: In a multistep participative design we identified key interests of adolescent patients with hypospadias. Next, a questionnaire addressing specifically the psychosexual satisfaction of adolescents after hypospadias repair was established...
November 15, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27887915/voiding-patterns-of-adult-patients-who-underwent-hypospadias-repair-in-childhood
#5
Jawdat Jaber, Stanislav Kocherov, Leonid Chertin, Amicur Farkas, Boris Chertin
OBJECTIVE: This study aimed at evaluating the voiding patterns of adult patients who underwent hypospadias repair in childhood. METHOD: Following IRB approval 103 (22.7%) of 449 adult patients who underwent hypospadias repair between 1978 and 1993 responded to the following questionnaires: International Prostate Symptom Score (I-PSS) and Short Form 12 questionnaire (SF-12). Uroflowmetry (UF) was performed for all patients. The patients were divided into three groups according to the primary meatus localization...
October 5, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27887912/application-of-the-strobe-statement-to-the-hypospadias-literature-report-of-the-international-pediatric-urology-task-force-on-hypospadias
#6
Luis H Braga, Armando J Lorenzo, Darius J Bagli, Joao L Pippi Salle, Anthony Caldamone
INTRODUCTION: Observational studies, particularly case series, represent the majority of the current hypospadias research. As a result, this literature lacks standardization of surgical techniques, uniform definitions of hypospadias complications, and consistency of outcome reporting, which may make it difficult to compare results across studies. A modified version of the STROBE statement, containing 20 items, was presented at the International Pediatric Urology Task Force on Hypospadias meeting to assist with clear and transparent reporting of hypospadias studies...
August 22, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27887909/modified-tubularized-incised-plate-urethroplasty-in-distal-hypospadias-repair-stepwise-technique-with-validated-functional-and-cosmetic-outcome
#7
A-F Spinoit, A Radford, J Ashraf, M Gopal, R Subramaniam
OBJECTIVE: To describe modification of the tubularized incised plate urethroplasty (TIP) for distal hypospadias, and assess its efficacy, and functional and cosmetic outcomes. METHODS: A prospective evaluation of a consecutive series of patients operated for primary distal hypospadias was conducted at a tertiary reference center. A standardized modification of the TIP (mTIP) procedure was performed on a 10 French catheter. Clinical data were collected in a dedicated database...
October 31, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27885243/di-n-butyl-phthalate-induced-hypospadias-relates-to-autophagy-in-genital-tubercle-via-the-pi3k-akt-mtor-pathway
#8
Xiang Li, Jinhao Li, Ya Zhang, Yun Zhou
OBJECTIVE: To explore the mechanisms of hypospadias induced by in utero exposure to din-butyl phthalate (DBP). METHODS: Timed-pregnant Sprague-Dawley rats were administered 750 mg/kg of DBP by gavage from GD (gestation days) 13 to GD 18, whereas control group received corn oil. Genital tubercles (GTs) and blood samples were collected from male fetuses on GD 19. The serum testosterone concentration, apoptosis activity, autophagosomes and their related proteins (light chain 3 (LC3-I, LC3-II)), and sequestosomes (SQSTM1/p62) in the GTs were then measured...
November 22, 2016: Journal of Occupational Health
https://www.readbyqxmd.com/read/27877098/accidental-epidural-injection-of-rocuronium-in-a-pediatric-patient-a-case-report-and-literature-review
#9
Ting-Ting Wu, David S Hoff
Accidental administration of non-epidural drugs into the epidural or subarachnoid spaces may be associated with unexpected pain, morbidity, adverse effects, increased level of care, prolonged hospital stay, and mortality. We describe a 12-month-old admitted for secondary-stage hypospadias reconstruction. General anesthesia was induced with sevofiurane and a peripheral catheter was placed. Instead of ropivacaine, rocuronium (80 mg; 6.3 mg/kg) was injected into the epidural space by the caudal route. Surgery was uneventful and was completed 160 minutes after rocuronium was given...
September 2016: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/27855149/placental-pathology-and-hypospadias
#10
Yan Chen, Luming Sun, Hongquan Geng, Xiaoping Lei, Jun Zhang
BACKGROUND: Studies have shown that hypospadias is associated with placenta-mediated pregnancy complication (PMPC). The role of placental lesions is still unclear. We aimed to examine the association between hyposadias and placental pathology, and the effect of PMPC. METHODS: Using data from the U.S. Collaborative Perinatal Project in 1959-1966, we identified 15,780 male subjects (167 hypospadias) for analysis. Detailed placental examinations were conducted following a standard protocol...
November 17, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27852690/maternal-use-of-mild-analgesics-during-pregnancy-associated-with-reduced-anogenital-distance-in-sons-a-cohort-study-of-1027-mother-child-pairs
#11
Dorte Vesterholm Lind, Katharina M Main, Henriette Boye Kyhl, David Møbjerg Kristensen, Jorma Toppari, Helle Raun Andersen, Marianne Skovsager Andersen, Niels E Skakkebæk, Tina Kold Jensen
STUDY QUESTION: Is maternal use of mild analgesics in pregnancy associated with anogenital distance (AGD)-the distance from the anus to the genitals-in the offspring? SUMMARY ANSWER: Maternal use of mild analgesics [especially simultaneous use of paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs)] during pregnancy was associated with a shorter AGD in boys whereas no effect was found in girls. WHAT IS KNOWN ALREADY: Mild analgesics including paracetamol (acetaminophen) and NSAIDs (e...
November 16, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27848231/association-of-srd5a2-gene-mutations-with-risk-of-hypospadias-in-the-iranian-population
#12
M Rahimi, M Ghanbari, Z Fazeli, M Rouzrokh, S Omrani, R Mirfakhraie, M D Omrani
BACKGROUND: Hypospadias is one of the most common forms of congenital malformation of the male external genitalia worldwide. The ratio in the Iranian population is one in 250 live male births. The conversion of testosterone to dihydrotestosterone (DHT) in the presence of steroid 5α-reductase 2, which is encoded by SRD5A2 gene, plays an important role in the normal development of the male reproductive system. METHODS: We examined whether SRD5A2 gene mutations (V89L and A49T polymorphisms) are associated with the risk of hypospadias in the Iranian population...
November 15, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27847256/hypospadias-repair-with-the-glanular-frenular-collar-gfc-technique
#13
Hüseyin Özbey, Şeref Etker
BACKGROUND: In the normal human penis, the glans wings merge in the midline ventrally, but are separated by the 'septum glandis' in conjunction with the frenulum. The frenulum is also included in the formation of the distal (glanular and subcoronal) urethra, which has a special part known as the 'fossa navicularis'. This has inspired a hypospadias repair technique that simulates the development of the glanular and subcoronal urethra, which can be incorporated into the repair of all cases of hypospadias...
November 3, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27845139/re-appraisal-of-adult-genitalia-after-hypospadias-repair-do-laypersons-mind-the-difference
#14
Douglas A Canning
No abstract text is available yet for this article.
December 2016: Journal of Urology
https://www.readbyqxmd.com/read/27845138/re-urethrocutaneous-fistulae-after-hypospadias-repair-when-do-they-occur
#15
Douglas A Canning
No abstract text is available yet for this article.
December 2016: Journal of Urology
https://www.readbyqxmd.com/read/27845137/re-does-preputial-reconstruction-increase-complication-rate-of-hypospadias-repair-20-year-systematic-review-and-meta-analysis
#16
Douglas A Canning
No abstract text is available yet for this article.
December 2016: Journal of Urology
https://www.readbyqxmd.com/read/27843874/unusual-complication-of-prolonged-indwelling-urinary-catheter-iatrogenic-hypospadias
#17
Gunjan Garg, Vishal Baghele, Naveen Chawla, Atul Gogia, Atul Kakar
Long-time urethral catheterization may be responsible for various complications such as urethral stricture, urethral fracture, urinary tract infections, and hypospadias. Hypospadias is the most common congenital anomaly of male external genitalia. However, urethral catheter-induced iatrogenic hypospadias is a rare entity. In this article, we describe a case of an elderly male who was found to have iatrogenic hypospadias 2 months after urinary catheterization.
April 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/27825332/circumcision-related-tragedies-seen-in-children-at-the-komfo-anokye-teaching-hospital-kumasi-ghana
#18
Kwaku Addai Arhin Appiah, Christian Kofi Gyasi-Sarpong, Roland Azorliade, Ken Aboah, Dennis Odai Laryea, Kwaku Otu-Boateng, Kofi Baah-Nyamekye, Patrick Opoku Manu Maison, Douglas Arthur, Isaac Opoku Antwi, Benjamin Frimpong-Twumasi, Edwin Mwintiereh Yenli, Samuel Kodzo Togbe, George Amoah
BACKGROUND: Circumcision is a common minor surgical procedure and it is performed to a varying extent across countries and religions. Despite being a minor surgical procedure, major complications may result from it. In Ghana, although commonly practiced, circumcision-related injuries have not been well documented. This study is to describe the scope of circumcision-related injuries seen at the Komfo Anokye Teaching Hospital in Kumasi, Ghana. METHODS: The study was conducted at the Urology Unit of the Komfo Anokye Teaching Hospital in Kumasi...
November 8, 2016: BMC Urology
https://www.readbyqxmd.com/read/27814383/adult-gli2-gli3%C3%AE-699-male-and-female-mice-display-a-spectrum-of-genital-malformation
#19
Fei He, Pedram Akbari, Rong Mo, Jennifer J Zhang, Chi-Chung Hui, Peter C Kim, Walid A Farhat
Disorders of sexual development (DSD) encompass a broad spectrum of urogenital malformations and are amongst the most common congenital birth defects. Although key genetic factors such as the hedgehog (Hh) family have been identified, a unifying postnatally viable model displaying the spectrum of male and female urogenital malformations has not yet been reported. Since human cases are diagnosed and treated at various stages postnatally, equivalent mouse models enabling analysis at similar stages are of significant interest...
2016: PloS One
https://www.readbyqxmd.com/read/27809709/systematic-review-to-compare-urothelium-differentiation-with-urethral-epithelium-differentiation-in-fetal-development-as-a-basis-for-tissue-engineering-of-the-male-urethra
#20
Petra de Graaf, E Martine van der Linde, Peter F W M Rosier, Ander Izeta, Karl-Dietrich Sievert, J L H Ruud Bosch, Laetitia M O de Kort
BACKGROUND: Tissue engineered (TE) urethra is desirable in men with urethral disease (stricture or hypospadias) and shortage of local tissue. Although ideally a TE graft would contain urethral epithelium cells, currently, bladder epithelium (urothelium) is widely used, but morphologically different. Understanding the differences and similarities of urothelium and urethral epithelium could help design a protocol for in vitro generation of urethral epithelium to be used in TE grafts for the urethra...
November 3, 2016: Tissue Engineering. Part B, Reviews
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