Yu Ding, Zu-Quan Chen, Wen-Feng Pan, Hao-Jie Chen, Min Wu, Yi-Qing Lyu, Hua Xie, Yi-Chen Huang, Zhong-Zhong Chen, Fang Chen
The second-to-fourth digit (2D:4D) ratio is thought to be associated with prenatal androgen exposure. However, the relationship between the 2D:4D ratio and hypospadias is poorly understood, and its molecular mechanism is not clear. In this study, by analyzing the hand digit length of 142 boys with hypospadias (23 distal, 68 middle, and 51 proximal) and 196 controls enrolled in Shanghai Children's Hospital (Shanghai, China) from December 2020 to December 2021, we found that the 2D:4D ratio was significantly increased in boys with hypospadias (P < 0...
March 29, 2024: Asian Journal of Andrology