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https://www.readbyqxmd.com/read/29334649/determining-variables-that-influence-the-phosphorus-content-of-waste-stabilization-pond-algae
#1
Matthew D Sells, Nicola Brown, Andrew N Shilton
Waste stabilization ponds (WSP) are one of the most common forms of wastewater treatment for smaller communities globally, but have poor phosphorus removal. It is known that WSP algae can accumulate polyphosphate within their cells in excess of that needed for cell function. If polyphosphate accumulation could be triggered at the higher range of WSP cell concentrations, phosphorus removal from domestic wastewater could be significantly improved. However, this phenomenon is sporadic and still not fully understood...
January 8, 2018: Water Research
https://www.readbyqxmd.com/read/29332760/ischemic-compression-and-kinesiotherapy-on-chronic-myofascial-pain-in-breast-cancer-survivors
#2
Flávia Belavenuto Rangon, Vânia Tiê Koga Ferreira, Monique Silva Rezende, Amanda Apolinário, Ana Paula Ferro, Elaine Caldeira de Oliveira Guirro
OBJECTIVE: assess the effects of ischemic compression and kinesiotherapy on the rehabilitation of breast cancer survivors with chronic myofascial pain. METHODS: A randomized, controlled, blinded clinical trial was performed with 20 breast cancer survivors with myofascial trigger point in the upper trapezius muscle. Patients were randomly allocated to ischemic compression + kinesiotherapy (G1, n = 10) and kinesiotherapy (G2, n = 10). Both groups were submitted to 10 sessions of treatment...
January 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29332745/a-critical-overview-of-the-current-myofascial-pain-literature-january-2018
#3
REVIEW
Jan Dommerholt, Todd Hooks, Li-Wei Chou, Michelle Finnegan
The majority of papers included in the quarterly review discuss various aspects of dry needling (DN), which continues to be of interest to researchers and clinicians. A study by Liu et al. is the first paper to examine the effects of DN of acetylcholine, esterase and receptors. The study provides support for the integrated trigger point hypothesis and for DN. A paper by Hightower and colleagues found an intriguing link between low magnesium levels in the drink water supply, vitamin D, and myofascial pain, cancer, tendon ruptures, and colon polyps...
January 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29330881/cocaine-and-hiv-1-tat-disrupt-cholesterol-homeostasis-in-astrocytes-implications-for-hiv-associated-neurocognitive-disorders-in-cocaine-user-patients
#4
Bianca Cotto, Kalimuthusamy Natarajaseenivasan, Kimberly Ferrero, Leroy Wesley, Matthew Sayre, Dianne Langford
Cholesterol synthesis and clearance by astrocytes are tightly regulated to maintain constant levels within the brain. In this context, liver X receptors (LXRs) are the master regulators of cholesterol homeostasis in the central nervous system (CNS). Increasing levels of cholesterol in astrocytes trigger LXR activation leading to the transcription of target genes involved in cholesterol trafficking and efflux, including apolipoprotein E, cytochrome P450 enzymes, sterol regulatory binding protein, and several ATP-binding cassette transporter proteins...
January 13, 2018: Glia
https://www.readbyqxmd.com/read/29330129/estradiol-up-regulates-l-type-ca2-channels-via-membrane-bound-estrogen-receptor-phosphoinositide-3kinase-akt-camp-response-element-binding-protein-signaling-pathway
#5
Xiaoyan Yang, Xiaofang Mao, Gao Xu, Shasha Xing, Ansuman Chattopadhyay, Si Jin, Guy Salama
BACKGROUND: In long QT type-2 (LQT2), women are more prone to lethal arrhythmias called Torsade de Pointes (TdP) than men. We previously reported that 17-β-estradiol (E2) upregulates L-type Ca2+-channels and current (ICa,L) (∼30%) in rabbit ventricular myocytes by a classical genomic-mechanism mediated by estrogen-receptor-α (ER)α. In LQT2 ( IKr-blockade or bradycardia), the higher Ca2+ influx via ICa,L, causes Ca2+-overload, spontaneous sarcoplasmic reticulum Ca2+-release, and re-activation of ICa,L that trigger early afterdepolarizations (EADs) and TdP...
January 9, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29328736/dynamical-formation-of-kerr-black-holes-with-synchronized-hair-an-analytic-model
#6
Carlos A R Herdeiro, Eugen Radu
East and Pretorius have successfully evolved, using fully nonlinear numerical simulations, the superradiant instability of the Kerr black hole (BH) triggered by a massive, complex vector field. Evolutions terminate in stationary states of a vector field condensate synchronized with a rotating BH horizon. We show that these end points are fundamental states of Kerr BHs with synchronized Proca hair. Motivated by the "experimental data" from these simulations, we suggest a universal (i.e., field-spin independent), analytic model for the subset of BHs with synchronized hair that possess a quasi-Kerr horizon, applicable in the weak hair regime...
December 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29327267/antimicrobial-peptide-gene-bdpho-responds-to-peptidoglycan-infection-and-mating-stimulation-in-oriental-fruit-fly-bactrocera-dorsalis-hendel
#7
Shi-Huo Liu, Hong-Fei Li, Yang Yang, Dong Wei, Hong-Bo Jiang, Wei Dou, Guo-Rui Yuan, Jin-Jun Wang
Phormicins belong to defensin family, which are important antimicrobial peptides (AMPs) in insects. These AMPs are inducible upon challenging by immune triggers. In the present study, we identified the cDNA of a phormicin gene (BdPho) in the oriental fruit fly, Bactrocera dorsalis (Hendel), a ruinous agricultural pest causing great economic losses to fruits and vegetables. The cDNA of BdPho contains a 282 bp open reading frame encoding 93 amino acid residues, and the predicted molecular weight and isoelectric point of BdPho peptide were 9...
January 11, 2018: AMB Express
https://www.readbyqxmd.com/read/29321971/processing-and-regulation-of-negative-emotions-in-anorexia-nervosa-an-fmri-study
#8
Maria Seidel, Joseph A King, Franziska Ritschel, Ilka Boehm, Daniel Geisler, Fabio Bernardoni, Matthias Beck, Sophie Pauligk, Ronald Biemann, Alexander Strobel, Thomas Goschke, Henrik Walter, Veit Roessner, Stefan Ehrlich
Theoretical models and recent advances in the treatment of anorexia nervosa (AN) have increasingly focused on the role of alterations in the processing and regulation of emotions. To date, however, our understanding of these changes is still limited and reports of emotional dysregulation in AN have been based largely on self-report data, and there is a relative lack of objective experimental evidence or neurobiological data. The current functional magnetic resonance imaging (fMRI) study investigated the hemodynamic correlates of passive viewing and voluntary downregulation of negative emotions by means of the reappraisal strategy detachment in AN patients...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29321126/toward-mhealth-brief-contact-interventions-in-suicide-prevention-case-series-from-the-suicide-intervention-assisted-by-messages-siam-randomized-controlled-trial
#9
Sofian Berrouiguet, Mark Erik Larsen, Catherine Mesmeur, Michel Gravey, Romain Billot, Michel Walter, Christophe Lemey, Philippe Lenca
BACKGROUND: Research indicates that maintaining contact either via letter or postcard with at-risk adults following discharge from care services after a suicide attempt (SA) can reduce reattempt risk. Pilot studies have demonstrated that interventions using mobile health (mHealth) technologies are feasible in a suicide prevention setting. OBJECTIVE: The aim of this study was to report three cases of patients recruited in the Suicide Intervention Assisted by Messages (SIAM) study to describe how a mobile intervention may influence follow-up...
January 10, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29318878/ultrasensitive-enzyme-free-biosensor-by-coupling-cyclodextrin-functionalized-au-nanoparticles-and-high-performance-au-paper-electrode
#10
Xiaoxiao Zheng, Li Li, Kang Cui, Yan Zhang, Lina Zhang, Shenguang Ge, Jinghua Yu
Microfluidic paper-based analytical device (μPAD), originally developed for improving healthcare in developing countries, presents a simple yet powerful platform for performing low-cost and portable diagnostic devices. Here, we reported an enzyme-free μPAD for the detection of two tumor markers. Firstly, a porous structure of gold nanoparticles (AuNPs) modified paper working electrode (Au-PWE), with a feature of all-around conductivity and plenty of active sites favoring for the biological ligands attachment, was firstly fabricated as a sensor substrate...
January 10, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29317763/a-direct-effect-of-perception-on-action-when-grasping-a-cup
#11
E Rounis, V van Polanen, M Davare
Affordances represent features of an object that trigger specific actions. Here we tested whether the presence and orientation of a handle on a cup could bias grasping movements towards it in conditions where subjects were explicitly told to ignore the handle. We quantified the grip aperture profile of twelve healthy participants instructed to grasp a cup from its body while it either had no handle, a handle pointing towards, or away from the grasping hand (3 'move' conditions, with large grip aperture). To ensure the smaller grip aperture afforded by the handle was implicitly processed, we interspersed trials in which participants had to grasp the cup from its handle or a handle not attached to a cup with a small grip aperture...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29315872/theoretical-investigations-on-the-mechanistic-aspects-of-o2-activation-by-a-biomimetic-di-nitrosyl-iron-complex
#12
Ambar Banerjee, Souloke Sen, Ankan Paul
Though Dinitrosyl-Iron complexes (DNICs) are largely believed to act as NO carriers, topical experiments on model DNICs have suggested that they can also act as Nitrating agents in presence of dioxygen. Oxygen activation by DNICs have been implicated as a possible route for protein tyrosine nitration (PTN), which leads to neurodegenerative disorders. Herein using static and dynamic theoretical techniques we unravel a previously unknown dual state mechanistic paradigm for dioxygen activation of a biomimetic nitrating DNIC complex leading to phenolic nitration...
January 7, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29311064/high-content-screening-of-mmv-pathogen-box-for-plasmodium-falciparum-digestive-vacuole-disrupting-molecules-reveals-valuable-starting-points-for-drug-discovery
#13
Jie Xin Tong, Rajesh Chandramohanadas, Kevin Shyong-Wei Tan
Plasmodium falciparum infections leading to malaria have severe clinical manifestations and high mortality rates. Chloroquine (CQ), a former mainstay of malaria chemotherapy, has been rendered ineffective due to the emergence of wide-spread resistance. Recent studies, however, have unveiled a novel mode of action in which low micromolar levels of CQ permeabilized the parasite's digestive vacuole (DV) membrane, leading to calcium efflux, mitochondrial depolarization and DNA degradation. These phenotypes implicate the DV as an alternative target of CQ and suggests that DV disruption is an attractive target for exploitation through the screening for DV-disruptive antimalarials...
January 8, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29310871/what-does-it-take-to-change-an-editor-s-mind-identifying-minimally-important-difference-thresholds-for-peer-reviewer-rating-scores-of%C3%A2-scientific-articles
#14
Michael Callaham, Leslie K John
STUDY OBJECTIVE: We define a minimally important difference for the Likert-type scores frequently used in scientific peer review (similar to existing minimally important differences for scores in clinical medicine). The magnitude of score change required to change editorial decisions has not been studied, to our knowledge. METHODS: Experienced editors at a journal in the top 6% by impact factor were asked how large a change of rating in "overall desirability for publication" was required to trigger a change in their initial decision on an article...
January 5, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29310652/what-makes-patients-aware-of-their-artificial-knee-joint
#15
F L Loth, M C Liebensteiner, J M Giesinger, K Giesinger, H R Bliem, B Holzner
BACKGROUND: Joint awareness was recently introduced as a new concept for outcome assessment after total knee arthroplasty (TKA). Findings from qualitative and psychometric studies suggest that joint awareness is a distinct concept especially relevant to patients with good surgical outcome and patients at late follow-up time points. The aim of this study was to improve the understanding of the concept of joint awareness by identifying situations in which patients are aware of their artificial knee joint and to investigate what bodily sensations and psychological factors raise a patient's awareness of her/his knee...
January 8, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29310329/impact-of-iterative-reconstruction-vs-filtered-back-projection-on-image-quality-in-320-slice-ct-coronary-angiography-insights-from-the-core320-multicenter-study
#16
Ahmed Fareed, Andrea L Vavere, Elke Zimmermann, Yutaka Tanami, Chloe Steveson, Matthew Matheson, Narinder Paul, Melvin Clouse, Christopher Cox, João A C Lima, Armin Arbab-Zadeh
Iterative reconstruction has been shown to reduce image noise compared with traditional filtered back projection with quantum denoising software (FBP/QDS+) in CT imaging but few comparisons have been made in the same patients without the influence of interindividual factors. The objective of this study was to investigate the impact of adaptive iterative dose reduction in 3-dimensional (AIDR 3D) and FBP/QDS+-based image reconstruction on image quality in the same patients.We randomly selected 100 patients enrolled in the coronary evaluation using 320-slice CT study who underwent CT coronary angiography using prospectively electrocardiogram triggered image acquisition with a 320-detector scanner...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29308808/alkaline-earth-be-mg-and-ca-bonds-at-the-origin-of-huge-acidity-enhancements
#17
M Merced Montero-Campillo, Pablo Sanz, Otilia Mó, Manuel Yáñez, Ibon Alkorta, José Elguero
The interaction between alkaline-earth derivatives with the general formula X2M (X = H, F and Cl; M = Be, Mg and Ca) and a set of Lewis bases, including first and second-row hydrides, namely YHn (Y = O, N, F, S, P and Cl) hydrides, as well as other typical cyclic organic bases, such as aniline, 1H-1,2,3-triazole, 1H-tetrazole and phenylphosphine, was investigated using the G4 ab initio composite method. Contrary to what was expected, it was found that the interactions involving Mg and Ca derivatives were not necessarily weaker than those between beryllium bonds...
January 8, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29308684/increase-of-reactive-oxygen-species-in-different-tissues-during-lipopolysaccharide-induced-fever-and-antipyresis-an-electron-paramagnetic-resonance-study
#18
Bruna R B Gomes, Marina Firmino, Jardeson S Jorge, Maria L O Ferreira, Thays M Rodovalho, Simone N Weis, Gloria E P Souza, Paulo C Morais, Marcelo V Sousa, Paulo E N Souza, Fabiane H Veiga-Souza
Fever is a regulated increase in body temperature and a component of the acute-phase response, triggered mainly after the invasion of pathogens in the body. Reactive oxygen species (ROS) are generated during the physiological and pathological processes, and can act as both signaling molecules as well as promoters of oxidative stress. Male Wistar rats, pretreated with oral doses of acetaminophen, celecoxib, dipyrone, or ibuprofen 30 min before an intravenous lipopolysaccharide (LPS) or sterile saline injection, showed a reduced febrile response in all animals tested...
January 8, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29305936/modeling-cocaine-relapse-in-rodents-behavioral-considerations-and-circuit-mechanisms
#19
REVIEW
Mitchell R Farrell, Hannah Schoch, Stephen V Mahler
Addiction is a chronic relapsing disorder, in that most addicted individuals who choose to quit taking drugs fail to maintain abstinence in the long-term. Relapse is especially likely when recovering addicts encounter risk factors like small "priming" doses of drug, stress, or drug-associated cues and locations. In rodents, these same factors reinstate cocaine seeking after a period of abstinence, and extensive preclinical work has used priming, stress, or cue reinstatement models to uncover brain circuits underlying cocaine reinstatement...
January 3, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29300858/evidence-supporting-a-role-for-constitutive-ghrelin-receptor-signaling-in-fasting-induced-hyperphagia-in-male-mice
#20
Gimena Fernandez, Agustina Cabral, María F Andreoli, Alexandra Labarthe, Céline M'Kadmi, Jorge G Ramos, Jacky Marie, Jean-Alain Fehrentz, Jacques Epelbaum, Virginie Tolle, Mario Perello
Ghrelin is a potent orexigenic peptide hormone that acts through the growth hormone secretagogue receptor (GHSR), a G-protein-coupled receptor highly expressed in the hypothalamus. In vitro studies have shown GHSR displays a high constitutive activity, whose physiological relevance is uncertain. Since GHSR gene expression in the hypothalamus is known to increase in fasting conditions, we tested the hypothesis that constitutive GHSR activity at hypothalamic level drives the fasting-induced hyperphagia. We found refed wild-type (WT) mice displayed a robust hyperphagia that continued for 5 days after refeeding and changed their food intake daily pattern...
December 28, 2017: Endocrinology
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