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https://www.readbyqxmd.com/read/28926414/exploration-of-quantitative-sensory-testing-in-latent-trigger-points-and-referred-pain-areas
#1
Silvia Ambite-Quesada, José L Arías-Buría, Carol A Courtney, Lars Arendt-Nielsen, César Fernández-de-Las-Peñas
OBJECTIVE: To investigate somato-sensory nerve fibre function by applying different quantitative sensory testing including thermal, mechanical and vibration thresholds over latent trigger points (TrP) and in its associated referred pain area. METHODS: A total of 20 subjects with unilateral latent TrPs in the extensor carpi radialis brevis were included. Warmth detection threshold (WDT), cold detection threshold CDT) and heat/cold pain thresholds (HPT, CPT), mechanical detection (MDT) and pain (MPT) thresholds, vibration threshold (VT), and pressure pain thresholds (PPT) were blinded assessed over the TrP, in the referred pain area, and in the respective contra-lateral mirror areas...
September 15, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28924479/marked-hyperandrogenicity-in-a-60-year-old-woman
#2
Khaled Aljenaee, Sulaiman Ali, Seong Keat Cheah, Owen MacEneaney, Niall Mulligan, Neil Hickey, Tommy Kyaw Tun, Seamus Sreenan, John H McDermott
Markedly elevated androgen levels can lead to clinical virilization in females. Clinical features of virilization in a female patient, in association with biochemical hyperandrogenism, should prompt a search for an androgen-producing tumor, especially of ovarian or adrenal origin. We herein report the case of a 60-year-old woman of Pakistani origin who presented with the incidental finding of male pattern baldness and hirsutism. Her serum testosterone level was markedly elevated at 21 nmol/L (normal range: 0...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28923396/smac-mimetics-and-type-ii-interferon-synergistically-induce-necroptosis-in-various-cancer-cell-lines
#3
Michael John Cekay, Stefanie Roesler, Tanja Frank, Anne-Kathrin Knuth, Ines Eckhardt, Simone Fulda
Since cancer cells often evade apoptosis, induction of necroptosis as another mode of programmed cell death is considered as a promising therapeutic alternative. Here, we identify a novel synergistic interaction of Smac mimetics that antagonize x-linked Inhibitor of Apoptosis (XIAP), cellular Inhibitor of Apoptosis (cIAP) 1 and 2 with interferon (IFN)γ to induce necroptosis in apoptosis-resistant cancer cells in which caspase activation is blocked. The synergistic is confirmed by calculation of combination indices (CIs) and found in both solid and hematological cancer cell lines as well as for different Smac mimetics (i...
September 15, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28923050/dry-needling-in-a-manual-physiotherapy-and-therapeutic-exercise-protocol-for-patients-with-chronic-mechanical-shoulder-pain-of-unspecific-origin-a-protocol-for-a-randomized-control-trial
#4
Emma Tejera-Falcón, Nuria Del Carmen Toledo-Martel, Francisco Manuel Sosa-Medina, Fátima Santana-González, Miriam Del Pino Quintana-de la Fe, Tomás Gallego-Izquierdo, Daniel Pecos-Martín
BACKGROUND: Shoulder pain of musculoskeletal origin is the main cause of upper limb pain of non-traumatic origin. Despite being one of the most common reasons for consultation, there is no established protocol for treatment due to the complexity of its etiology. However, it has been shown that the presence of myofascial trigger points on the shoulder muscles is a common condition associated with patients suffering from shoulder pain. This protocol has been created which describes the design of a randomized controlled trial to evaluate the effectiveness of the inclusion of dry needling (DN) within a protocol of manual physiotherapy and therapeutic exercise in the treatment of chronic shoulder pain of unspecific origin...
September 18, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28922393/a-set-of-nutrient-limitations-trigger-yeast-cell-death-in-a-nitrogen-dependent-manner-during-wine-alcoholic-fermentation
#5
Camille Duc, Martine Pradal, Isabelle Sanchez, Jessica Noble, Catherine Tesnière, Bruno Blondin
Yeast cell death can occur during wine alcoholic fermentation. It is generally considered to result from ethanol stress that impacts membrane integrity. This cell death mainly occurs when grape musts processing reduces lipid availability, resulting in weaker membrane resistance to ethanol. However the mechanisms underlying cell death in these conditions remain unclear. We examined cell death occurrence considering yeast cells ability to elicit an appropriate response to a given nutrient limitation and thus survive starvation...
2017: PloS One
https://www.readbyqxmd.com/read/28920423/self-organization-of-ions-at-the-interface-between-graphene-and-ionic-liquid-deme-tfsi
#6
Guangliang Hu, Gaind P Pandey, Qingfeng Liu, Radhika S Anaredy, Chunrui Ma, Ming Liu, Jun Li, Scott K Shaw, Judy Z Wu
Electrochemical effects manifest as nonlinear responses to an applied electric field in electrochemical devices, and are linked intimately to the molecular orientation of ions in the electric double layer (EDL). Herein, we probe the origin of the electrochemical effect using a double-gate graphene field effect transistor (GFET) of ionic liquid N,N-diethyl-N-(2-methoxyethyl)-N-methylammonium bis-(trifluoromethylsulfonyl)-imide (DEME-TFSI) top-gate, paired with a ferroelectric Pb0.92La0.08Zr0.52Ti0.48O3 (PLZT) back-gate of compatible gating efficiency...
September 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28916540/massive-reshaping-of-genome-nuclear-lamina-interactions-during-oncogene-induced-senescence
#7
Christelle Lenain, Carolyn A de Graaf, Ludo Pagie, Nils L Visser, Marcel de Haas, Sandra S de Vries, Daniel Peric-Hupkes, Bas van Steensel, Daniel S Peeper
Cellular senescence is a mechanism that virtually irreversibly suppresses the proliferative capacity of cells in response to various stress signals. This includes the expression of activated oncogenes, which causes Oncogene-Induced Senescence (OIS). A body of evidence points to the involvement in OIS of chromatin reorganization, including the formation of senescence-associated heterochromatic foci (SAHF). The nuclear lamina (NL) is an important contributor to genome organization and has been implicated in cellular senescence and organismal aging...
September 15, 2017: Genome Research
https://www.readbyqxmd.com/read/28916249/diagnostic-errors-impact-of-an-educational-intervention-on-pediatric-primary-care
#8
Julianne Nemes Walsh, Margaret Knight, A James Lee
INTRODUCTION: The purpose of our study was to determine the impact of an educational program on a provider's knowledge related to diagnostic errors and diagnostic reasoning strategies. METHODS: A quasi-experimental interventional study with a multimedia approach, case study discussion, and trigger-generated medical record review at two time points was conducted. Measurement tools included a test developed by the National Patient Safety Foundation, Reducing Diagnostic Errors: Strategies for Solutions Quiz, additional diagnostic reasoning questions, and a trigger-generated process to analyze medical records...
September 12, 2017: Journal of Pediatric Health Care
https://www.readbyqxmd.com/read/28913358/central-modulation-of-neuroinflammation-by-neuropeptides-and-energy-sensing-hormones-during-obesity
#9
REVIEW
Roger Maldonado-Ruiz, Lizeth Fuentes-Mera, Alberto Camacho
Central nervous system (CNS) senses energy homeostasis by integrating both peripheral and autonomic signals and responding to them by neurotransmitters and neuropeptides release. Although it is previously considered an immunologically privileged organ, we now know that this is not so. Cells belonging to the immune system, such as B and T lymphocytes, can be recruited into the CNS to face damage or infection, in addition to possessing resident immunological cells, called microglia. In this way, positive energy balance during obesity promotes an inflammatory state in the CNS...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28913345/a-yeast-model-for-the-mechanism-of-the-epstein-barr-virus-immune-evasion-identifies-a-new-therapeutic-target-to-interfere-with-the-virus-stealthiness
#10
COMMENT
María José Lista, Rodrigo Prado Martins, Gaelle Angrand, Alicia Quillévéré, Chrysoula Daskalogianni, Cécile Voisset, Marie-Paule Teulade-Fichou, Robin Fåhraeus, Marc Blondel
The oncogenic Epstein-Barr virus (EBV) evades the immune system but has an Achilles heel: its genome maintenance protein EBNA1. Indeed, EBNA1 is essential for viral genome replication and maintenance but also highly antigenic. Hence, EBV evolved a system in which the glycine-alanine repeat (GAr) of EBNA1 limits the translation of its own mRNA at a minimal level to ensure its essential function thereby, at the same time, minimizing immune recognition. Defining intervention points where to interfere with EBNA1 immune evasion is an important step to trigger an immune response against EBV-carrying cancers...
August 31, 2017: Microbial Cell
https://www.readbyqxmd.com/read/28912947/friction-massage-versus-kinesiotaping-for-short-term-management-of-latent-trigger-points-in-the-upper-trapezius-a-randomized-controlled-trial
#11
Marzieh Mohamadi, Soraya Piroozi, Iman Rashidi, Saeed Hosseinifard
BACKGROUND: Latent trigger points in the upper trapezius muscle may disrupt muscle movement patterns and cause problems such as cramping and decreased muscle strength. Because latent trigger points may spontaneously become active trigger points, they should be addressed and treated to prevent further problems. In this study we compared the short-term effect of kinesiotaping versus friction massage on latent trigger points in the upper trapezius muscle. METHODS: Fifty-eight male students enrolled with a stratified sampling method participated in this single-blind randomized clinical trial (Registration ID: IRCT2016080126674N3) in 2016...
2017: Chiropractic & Manual Therapies
https://www.readbyqxmd.com/read/28912275/nmr-reveals-the-intrinsically-disordered-domain-2-of-ns5a-protein-as-an-allosteric-regulator-of-the-hepatitis-c-virus-rna-polymerase-ns5b
#12
Luiza M Bessa, Hélène Launay, Marie Dujardin, François-Xavier Cantrelle, Guy Lippens, Isabelle Landrieu, Robert Schneider, Xavier Hanoulle
Non-structural protein 5B (NS5B) is the RNAdependent RNA polymerase that catalyses replication of the hepatitis C virus (HCV) RNA genome, and so is central for its life cycle. NS5B interacts with the intrinsically disordered domain 2 of NS5A (NS5A-D2), another essential multifunctional HCV protein that is required for RNA replication. As a result, these two proteins represent important targets for anti-HCV chemotherapies. Despite this importance and the existence of NS5B crystal structures, our understanding of the conformational and dynamic behaviour of NS5B in solution and its relationship with NS5A-D2 remain incomplete...
September 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28910109/membrane-tubulation-in-lipid-vesicles-triggered-by-the-local-application-of-calcium-ions
#13
Baharan Ali Doosti, Weria Pezeshkian, Dennis Skjøth Bruhn, John Hjort Ipsen, Himanshu Khandelia, Gavin D M Jeffries, Tatsiana Lobovkina
Experimental and theoretical studies on ion-lipid interactions, predict that binding of calcium ions to cell membranes leads to macroscopic mechanical effects and membrane remodeling. Herein, we provide experimental evidence that a point-source of Ca2+ acting upon a negatively charged membrane, generates spontaneous curvature and triggers the formation of tubular protrusions that point away from the ion source. This behavior is rationalized by strong binding of the divalent cations to the surface of the charged bilayer which effectively neutralizes the surface charge density of outer leaflet of the bilayer...
September 14, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28906594/understanding-the-molecular-basis-for-multiple-mitochondrial-dysfunctions-syndrome-1-mmds1-impact-of-a-disease-causing-gly189arg-substitution-on-nfu1
#14
Nathaniel A Wesley, Christine Wachnowsky, Insiya Fidai, J A Cowan
Iron-sulfur (Fe/S) cluster-containing proteins constitute one of the largest protein classes, with highly-varied function. Consequently, the biosynthesis of Fe/S clusters is evolutionarily conserved and mutations in intermediate Fe/S cluster scaffold proteins can cause disease, including multiple mitochondrial dysfunctions syndrome (MMDS). Herein, we have characterized the impact of defects occurring in the MMDS1 disease state that result from a point mutation (p.Gly189Arg) near the active site of NFU1, an iron-sulfur scaffold protein...
September 14, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28903087/control-strategies-for-nitrous-oxide-emissions-reduction-on-wastewater-treatment-plants-operation
#15
I Santín, M Barbu, C Pedret, R Vilanova
The present paper focused on reducing greenhouse gases emissions in wastewater treatment plants operation by application of suitable control strategies. Specifically, the objective is to reduce nitrous oxide emissions during the nitrification process. Incomplete nitrification in the aerobic tanks can lead to an accumulation of nitrite that triggers the nitrous oxide emissions. In order to avoid the peaks of nitrous oxide emissions, this paper proposes a cascade control configuration by manipulating the dissolved oxygen set-points in the aerobic tanks...
August 28, 2017: Water Research
https://www.readbyqxmd.com/read/28898586/transcerebral-net-exchange-of-vasoactive-peptides-and-catecholamines-during-lipopolysaccharide-induced-systemic-inflammation-in-healthy-humans
#16
Ronan M G Berg, Sarah Taudorf, Damian Miles Bailey, Rasmus Holmboe Dahl, Carsten Lundby, Kirsten Møller
The systemic inflammatory response triggered by lipopolysaccharide (LPS) is associated with cerebral vasoconstriction, but the underlying mechanisms are unknown. We therefore examined whether a four-hour intravenous LPS infusion (0.3 ng kg<sup>-1</sup>) induces any changes in the transcerebral net exchange of the vasoactive peptides endothelin-1 (ET-1) and calcitonin-gene related peptide (CGRP) and catecholamines in human volunteers. Cerebral blood flow was measured by the Kety-Schmidt technique, and paired arterial-to-jugular venous blood samples were obtained for estimating the transcerebral exchange of ET-1, CGRP and catecholamines by the Fick principle in twelve volunteers before and after LPS...
September 12, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28895501/nourishing-the-spirit-exploratory-research-on-ayahuasca-experiences-along-the-continuum-of-recovery-from-eating-disorders
#17
Adele Lafrance, Anja Loizaga-Velder, Jenna Fletcher, Marika Renelli, Natasha Files, Kenneth W Tupper
Eating disorders (EDs) are serious health conditions that are among the most difficult to treat. Innovative treatments are needed and modalities from across cultures must be considered. Ayahuasca is a psychoactive plant-based tea originally used by Amazonian indigenous groups. A growing body of research points to its promise in the healing of various mental health issues. This study explored the potential therapeutic value of ayahuasca in the context of EDs, including the perceived impact of the preparatory diet and the ayahuasca purge...
September 12, 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/28893414/transcriptional-mediated-effects-of-radiation-on-the-expression-of-immune-susceptibility-markers-in-melanoma
#18
Lauryn R Werner, Jasdeep S Kler, Monica M Gressett, Maureen Riegert, Lindsey K Werner, Clinton M Heinze, Joseph G Kern, Mahyar Abbariki, Amy K Erbe, Ravi B Patel, Raghava N Sriramaneni, Paul M Harari, Zachary S Morris
BACKGROUND AND PURPOSE: We recently reported a time-sensitive, cooperative, anti-tumor effect elicited by radiation (RT) and intra-tumoral-immunocytokine injection in vivo. We hypothesized that RT triggers transcriptional-mediated changes in tumor expression of immune susceptibility markers at delayed time points, which may explain these previously observed time-dependent effects. MATERIALS AND METHODS: We examined the time course of changes in expression of immune susceptibility markers following in vitro or in vivo RT in B78 murine melanoma and A375 human melanoma using flow cytometry, immunoblotting, and qPCR...
September 8, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28892785/parental-gamma-irradiation-induces-reprotoxic-effects-accompanied-by-genomic-instability-in-zebrafish-danio-rerio-embryos
#19
Selma Hurem, Tânia Gomes, Dag A Brede, Elisabeth Lindbo Hansen, Stephen Mutoloki, Cristian Fernandez, Carmel Mothersill, Brit Salbu, Yetneberk A Kassaye, Ann-Karin Olsen, Deborah Oughton, Peter Aleström, Jan L Lyche
Gamma radiation represents a potential health risk to aquatic and terrestrial biota, due to its ability to ionize atoms and molecules in living tissues. The effects of exposure to (60)Co gamma radiation in zebrafish (Danio rerio) were studied during two sensitive life stages: gametogenesis (F0: 53 and 8.7mGy/h for 27 days, total doses 31 and 5.2Gy) and embryogenesis (9.6mGy/h for 65h; total dose 0.62Gy). Progeny of F0 exposed to 53mGy/h showed 100% mortality occurring at the gastrulation stage corresponding to 8h post fertilization (hpf)...
September 8, 2017: Environmental Research
https://www.readbyqxmd.com/read/28891455/epigenetic-biomarkers-for-risk-assessment-of-particulate-matter-associated-lung-cancer
#20
Arpit Bhargava, Neha Bunkar, Aniket Aglawe, Kailash Chand Pandey, Rajnarayan Tiwari, Koel Chaudhury, Irina Yu Goryacheva, Pradyumna Kumar Mishra
BACKGROUND: Particulate matter directly emitted into the air by sources such as combustion processes and windblown dust, or formed in the atmosphere by transformation of emitted gases are the major contributors to air pollution that triggers a diverse array of human pathologies including lung cancer. The mortality in lung cancer is usually high as the disease is not symptomatic at its early treatable stage. Moreover, available methods for screening are costly and mainly rely on imaging techniques which lack sufficient sensitivity and specificity...
September 10, 2017: Current Drug Targets
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