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https://www.readbyqxmd.com/read/29331206/mechanical-thrombectomy-determining-the-proportion-of-eligible-acute-ischemic-stroke-patients-in-the-cohort-of-single-academic-stroke-center
#1
Marcin Wiącek, Rafał Kaczorowski, Bartosz Sieczkowski, Natalia Kanas, Halina Bartosik-Psujek
BACKGROUND AND PURPOSE: Mechanical thrombectomy (MT) is now well-established treatment method for selected patients with acute ischemic stroke (AIS) and efforts are being made to incorporate it into the systems of stroke care. Our objective is to assess the number of AIS individuals eligible for MT in the cohort of single academic stroke center. METHODS: We retrospectively reviewed initial non-invasive vascular imaging data of AIS patients presenting within 5h of symptom onset for the presence of large vessel occlusion (LVO) over 2-year period (2015-2016)...
December 26, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29329732/changes-in-quantitative-ct-image-features-of-ground-glass-nodules-in-differentiating-invasive-pulmonary-adenocarcinoma-from-benign-and-in-situ-lesions-histopathological-comparisons
#2
Y P Zhang, M A Heuvelmans, H Zhang, M Oudkerk, G X Zhang, X Q Xie
AIM: To evaluate progressive changes in quantitative CT features of the non-solid component of ground-glass nodules (GGNs) from baseline to follow-up to differentiate invasive (minimally invasive adenocarcinoma [MIA] and invasive adenocarcinoma [IA]) GGNs from benign or pre-invasive (adenocarcinoma in situ [AIS]) lesions. MATERIALS AND METHODS: Patients with a GGN detected at baseline and follow-up computed tomography (CT), examined by tissue sampling were included in the study...
January 9, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29329697/ageing-perceptions-and-non-adherence-to-aromatase-inhibitors-among-breast-cancer-survivors
#3
Moriah J Brier, Dianne L Chambless, Jinbo Chen, Jun J Mao
PURPOSE: Aromatase inhibitors (AIs) are a potentially life-saving treatment for breast cancer survivors, yet poor adherence to treatment is a prevalent problem. A common adverse effect of AI treatment is arthralgia, which is identified by survivors as a major reason for treatment discontinuation. Women who experience arthralgia on AIs often report feeling they have aged rapidly while on the treatment. In the present study, we examined whether arthralgia-associated ageing perceptions predicted non-adherence...
January 9, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29326761/prevalence-rate-of-adolescent-idiopathic-scoliosis-results-of-school-based-screening-in-surabaya-indonesia
#4
I S Komang-Agung, S B Dwi-Purnomo, A Susilowati
Introduction: Scoliosis is a lateral spinal deformity of 10 degrees or more, resulting in a C-shaped or S-shaped curve of the spine. Information about adolescent idiopathic scoliosis (AIS) prevalence rate is important not only for paediatric health care planning strategy but also for parent's awareness. This study aims to find the suitable inclination cut-off angle and the prevalence rate of AIS in Surabaya, Indonesia. Materials and Methods: This is a descriptive cross-sectional study conducted in 2010. We performed stratified random sampling of 784 Elementary and Junior High School students in Surabaya between 9-16 years of age...
November 2017: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/29325936/carotid-atherosclerotic-plaque-features-in-patients-with-acute-ischemic-stroke
#5
Runming Sun, Lixia Wang, Cuiling Guan, Wenyuan Cao, Bing Tian
OBJECTIVE: To investigate the carotid atherosclerotic plaque features in patients with acute ischemic stroke (AIS). METHODS: A total of 288 patients meeting the included criteria were enrolled and divided into ulcer plaque group (n = 139) and none ulcer plaque group (n = 149). Patients in ulcer plaque group were further subdivided into < and ≥ 50% stenosis group. Carotid plaque components characteristics including luminal stenosis, carotid plaque volume, hypoechoic plaque volume and hyperechoic plaque volume were analyzed by color Doppler ultrasound measurement...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29325878/can-we-identify-futility-in-kids-an-evaluation-of-admission-parameters-predicting-100-mortality-in-1292-severely-injured-children
#6
Kyle J Kalkwarf, Shane D Jensen, Myron Allukian, Matthew T Harting, Charles S Cox, Erin E Fox, Charles E Wade, Bryan A Cotton
BACKGROUND: Objective parameters predicting futility of care in severely injured pediatric patients are lacking. While futility of care has been investigated in a limited number of studies in trauma patients, none of these studies achieves a 100% success rate in a large cohort of pediatric patients. The purpose of the current study was to identify extreme laboratory values that could be used to predict 100% mortality in severely injured children. STUDY DESIGN: Registry-based, historical cohort of all severely injured children (level 1 trauma, <16 years old), who were not dead on arrival, between January 2010 and December 2016 from a single level 1 trauma center...
January 8, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29322481/influence-of-thrombolysis-on-the-safety-and-efficacy-of-blocking-platelet-adhesion-or-secretory-activity-in-acute-ischemic-stroke-in-mice
#7
Michael K Schuhmann, Peter Kraft, Michael Bieber, Axel Haarmann, György A Homola, Mirko Pham, Bernhard Nieswandt, Guido Stoll
In acute ischemic stroke (AIS), there is an alarming discrepancy between recanalization rates of up to 70% by combined recombinant tissue-type plasminogen activator (rt-PA) therapy and mechanical thrombectomy, and no clinical benefit in at least every second stroke patient. This is partly due to ischemia/reperfusion (I/R) injury. In a translational approach, we used mice lacking dense- (Unc13d -/- ) or α-granules (Nbeal2 -/- ) and mice after blocking of platelet glycoprotein receptor (GP) Ib conferring protection from I/R injury...
January 10, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/29318283/screening-for-adolescent-idiopathic-scoliosis-evidence-report-and-systematic-review-for-the-us-preventive-services-task-force
#8
John Dunn, Nora B Henrikson, Caitlin C Morrison, Paula R Blasi, Matt Nguyen, Jennifer S Lin
Importance: Adolescent idiopathic scoliosis (AIS), a spinal curvature of 10° or more, is the most common form of scoliosis, with a prevalence of 1% to 3%. Curves progress in approximately two-thirds of patients with AIS before skeletal maturity, and large curves (>50°) may be associated with adverse health outcomes. Objective: To systematically review evidence on benefits and harms of AIS screening for the US Preventive Services Task Force (USPSTF). Data Sources: Cochrane Central Register of Controlled Trials, MEDLINE, ERIC, PubMed, CINAHL, and relevant systematic reviews were searched for studies published from January 1966 to October 20, 2016; studies included in a previous USPSTF report were also reviewed...
January 9, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29316846/acute-stress-evokes-sexually-dimorphic-stressor-specific-patterns-of-neural-activation-across-multiple-limbic-brain-regions-in-adult-rats
#9
Ankit Sood, Karina Chaudhari, Vidita A Vaidya
Stress enhances the risk for psychiatric disorders such as anxiety and depression. Stress responses vary across sex and may underlie the heightened vulnerability to psychopathology in females. Here, we examined the influence of acute immobilization stress (AIS) and a two-day short-term forced swim stress (FS) on neural activation in multiple cortical and subcortical brain regions, implicated as targets of stress and in the regulation of neuroendocrine stress responses, in male and female rats using Fos as a neural activity marker...
January 10, 2018: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/29316820/cost-effectiveness-of-access-to-critical-cerebral-emergency-support-services-access-a-neuro-emergent-telemedicine-consultation-program
#10
Justin Whetten, David N van der Goes, Huy Tran, Mark Moffett, Colin Semper, Howard Yonas
AIMS: Access to Critical Cerebral Emergency Support Services (ACCESS) was developed as a low-cost solution to providing neuro-emergent consultations to rural hospitals in New Mexico that do not offer comprehensive stroke care. ACCESS is a two-way audio visual program linking remote emergency department physicians and their patients to stroke specialists. ACCESS also has an education component in which hospitals receive training from stroke specialists on the triage and treatment of patients...
January 9, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29312701/analysis-of-pulmonary-pure-ground-glass-nodule-in-enhanced-dual-energy-ct-imaging-for-predicting-invasive-adenocarcinoma-comparing-with-conventional-thin-section-ct-imaging
#11
Ying Zhang, Jian Tang, Jianrong Xu, Jiejun Cheng, Huawei Wu
Background: To investigate the value of dual energy computed tomography (DECT) parameters (including iodine concentration and monochromatic CT numbers) for predicting pure ground-glass nodules (pGGNs) of invasive adenocarcinoma (IA). Methods: A total of 55 resected pGGNs evaluated with both unenhanced thin-section CT (TSCT) and enhanced DECT scans were included. Correlations between histopathology [adenocarcinoma in situ (AIS), minimally IA (MIA), and IA] and CT scan characteristics were examined...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29312645/serum-galectin-3-level-not-galectin-1-is-associated-with-the-clinical-feature-and-outcome-in-patients-with-acute-ischemic-stroke
#12
Han Dong, Zhi-Hao Wang, Na Zhang, Si-Da Liu, Jian-Jun Zhao, Song-Yan Liu
Aim: To study the diagnostic and prognostic role of serum galectin-1 (Gal-1) and -3 (Gal-3) in acute ischemic stroke (AIS) patients. Methods: We enrolled 233 patients with first-ever acute ischemic stroke and 252 healthy controls in this study. The AIS severity was evaluated by National Institutes of Health Stroke Scale (NIHSS) scores. The serum Gal-1 and -3 levels were determined. All patients were followed for 1 years and the functional outcome were evaluated by modified Rankin Scale (mRS) scores...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29309975/anterior-versus-posterior-selective-fusion-in-treating-adolescent-idiopathic-scoliosis-a-systematic-review-and-meta-analysis-of-radiological-parameters
#13
Yang Lin, Wenjian Chen, Anmin Chen, Feng Li, Wei Xiong
OBJECTIVE: To compare the clinical efficacy of anterior and posterior approaches for selective thoracic fusion (STF) and selective thoracolumbar/lumbar fusion (SLF) in treating adolescent Idiopathic scoliosis (AIS). METHODS: English-language literature on selective fusion treatment of AIS published before September 2016 was retrieved from the PubMed, Embase, Cochrane, and Google Scholar databases. Studies were manually selected for inclusion based on preset criteria...
January 5, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29308673/glial-fibrillary-acidic-protein-as-a-prognostic-marker-of-acute-ischemic-stroke
#14
G Liu, J Geng
BACKGROUND: We investigated the association between serum levels of glial fibrillary acidic protein (GFAP) and stroke functional outcomes in a cohort of 286 patients with acute ischemic stroke (AIS). METHODS: We prospectively studied 286 patients with AIS who were admitted within 24 h after the onset of symptoms. Serum levels of GFAP and National Institutes of Health Stroke Scale (NIHSS) were measured at admission. The primary end point was stroke functional outcome among 1-year after stroke onset...
January 1, 2018: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29307591/radiologic-pathologic-correlation-of-solid-portions-on-thin-section-ct-images-in-lung-adenocarcinoma-a-multicenter-study
#15
Masahiro Yanagawa, Masahiko Kusumoto, Takeshi Johkoh, Masayuki Noguchi, Yuko Minami, Fumikazu Sakai, Hisao Asamura, Noriyuki Tomiyama
BACKGROUND: Measuring the size of invasiveness on computed tomography (CT) for the T descriptor size was deemed important in the 8th edition of the TNM lung cancer classification. We aimed to correlate the maximal dimensions of the solid portions using both lung and mediastinal window settings on CT imaging with the pathologic invasiveness (> 0.5 cm) in lung adenocarcinoma patients. MATERIALS AND METHODS: The study population consisted of 378 patients with a histologic diagnosis of adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), invasive adenocarcinoma (IVA)-lepidic, IVA-acinar and/or IVA-papillary, and IVA-micropapillary and/or solid adenocarcinoma...
December 19, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29306231/the-efficacy-of-in-situ-local-autograft-in-adolescent-idiopathic-scoliosis-surgery-a-comparison-of-three-different-grafting-methods
#16
Metin Işık, Hacı Mustafa Özdemir, Abdurrahman Sakaoğulları, Bertan Cengiz, Nevres Hürriyet Aydoğan
Background/aim: This study was performed to show the efficacy of in situ local autograft with a comparison of in situ local autograft, local autograft with allograft, and local autograft with posterior iliac crest autograft.Materials and methods: In this prospective randomized study, a total of 65 adolescent idiopathic scoliosis (AIS) patients were separated into 3 groups: Group 1 using local autograft and allograft, Group 2 using local autograft only, and Group 3 using local autograft and posterior iliac crest autograft...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29305713/the-benefit-of-ultrasound-in-deciding-between-tube-thoracostomy-and-observative-management-in-hemothorax-resulting-from-blunt-chest-trauma
#17
Meng-Hsuan Chung, Chen-Yuan Hsiao, Nai-Shin Nian, Yen-Chia Chen, Chien-Ying Wang, Yi-Szu Wen, Hsin-Chin Shih, David Hung-Tsang Yen
BACKGROUND: Hemothorax is most commonly resulted from a closed chest trauma, while a tube thoracostomy (TT) is usually the first procedure attempted to treat it. However, TT may lead to unexpected results and complications in some cases. The advantage of thoracic ultrasound (TUS) over a physical examination combined with chest radiograph (CXR) for diagnosing hemothorax1 has been proposed previously. However, its benefits in terms of avoiding non-therapeutic TT have not yet been confirmed...
January 5, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29304393/factors-associated-with-insomnia-in-pregnancy-a-prospective-cohort-study
#18
R M Román-Gálvez, C Amezcua-Prieto, I Salcedo-Bellido, J M Martínez-Galiano, K S Khan, A Bueno-Cavanillas
OBJECTIVE: To quantify insomnia and their components in a longitudinal cohort of pregnant women and factors associated with insomnia. STUDY DESIGN: A prospective cohort of 486 healthy singleton pregnancies assembled before the 14th gestational week (February 2013 to March 2016). Insomnia data were collected pre-gestationally, in each trimester and six months post-partum, analysing five different moments. Multiple logistic regression analysis was performed to generate adjusted Odds Ratios (aOR) with 95% confidence intervals (CI) of determinants of insomnia in each trimester, defined using Athens Insomnia Scale (AIS) as score ≥8...
December 7, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29303440/predictive-value-of-positive-high-sensitivity-troponin-t-in-intubated-traumatic-brain-injury-patients
#19
Ayman El-Menyar, Mohammad Asim, Rifat Latifi, Shrikant I Bangdiwala, Hassan Al-Thani
OBJECTIVE The clinical relevance of high-sensitivity troponin T (HsTnT) in trauma patients is not well explored. In this study, the authors aimed to study the predictive value of serum HsTnT in intubated patients who had sustained traumatic brain injury (TBI). METHODS A retrospective analysis was conducted for all intubated TBI patients between 2010 and 2014 at a national level 1 trauma center. Data were analyzed and compared based on the HsTnT status on admission (group 1, negative results; and group 2, positive results)...
January 5, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29302990/relevance-of-the-updated-food-and-drug-administration-alteplase-label-for-acute-ischemic-stroke-the-estimated-impact-and-current-guidelines
#20
Harn J Shiue, Karen C Albright, Kara A Sands
In 2015, the Food and Drug Administration updated the contraindications for the use of alteplase in acute ischemic stroke (AIS), potentially creating a greater impact on treatment. A history of intracranial hemorrhage and recent stroke within 3 months were removed as contraindications, increasing the number of patients eligible for alteplase. The aim of this commentary is to call attention to the updates and discuss them relative to current American Heart Association/American Stroke Association guidelines. Additionally, we estimate the clinical impact of the updates by analyzing AIS admissions to a large-volume Comprehensive Stroke Center...
January 1, 2018: Annals of Pharmacotherapy
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