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https://www.readbyqxmd.com/read/28432539/early-onset-ventilator-associated-pneumonia-in-patients-with-severe-traumatic-brain-injury-incidence-risk-factors-and-consequences-in-cerebral-oxygenation-and-outcome
#1
Pierre Esnault, Cédric Nguyen, Julien Bordes, Erwan D'Aranda, Ambroise Montcriol, Claire Contargyris, Jean Cotte, Philippe Goutorbe, Christophe Joubert, Arnaud Dagain, Henry Boret, Eric Meaudre
BACKGROUND: Early-onset ventilator-associated pneumonia (EOVAP) occurs frequently in severe traumatic brain-injured patients, but potential consequences on cerebral oxygenation and outcome have been poorly studied. The objective of this study was to describe the incidence, risk factors for, and consequences on cerebral oxygenation and outcome of EOVAP after severe traumatic brain injury (TBI). METHODS: We conducted a retrospective, observational study including all intubated TBI admitted in the trauma center...
April 21, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28431990/a-common-polymorphism-decreases-lrp1-mrna-stability-and-is-associated-with-increased-plasma-factor-viii-levels
#2
Jiann-Der Lee, Kuang-Ming Hsiao, Pey-Jium Chang, Chih-Cheng Chen, Ya-Wen Kuo, Yen-Chu Huang, Huan-Lin Hsu, Ya-Hui Lin, Chih-Ying Wu, Ying-Chih Huang, Meng Lee, Chia-Yu Hsu, Yi-Ting Pan, Chih-Yu Kuo, Chun-Hsien Lin
The low-density lipoprotein receptor-related protein 1 (LRP1) gene is associated with increased levels of plasma factor VIII (FVIII). We aimed to explore eight functional genetic LRP1 variants for their potential roles in regulating FVIII levels and acute ischemic stroke (AIS). This genetic association study enrolled 192 patients with AIS and 134 controls. There were no significant differences in the genetic frequency of the eight functional single-nucleotide polymorphisms (SNPs) between the control and AIS groups...
April 18, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28431590/delays-in-door-to-needle-time-for-acute-ischemic-stroke-in-the-emergency-department-a-comprehensive-stroke-center-experience
#3
Ashkan Mowla, Jordan Doyle, Navdeep S Lail, Hamidreza Rajabzadeh-Oghaz, Christopher Deline, Peyman Shirani, Marilou Ching, Annemarie Crumlish, Deborah A Steck, David Janicke, Elad I Levy, Robert N Sawyer
BACKGROUND: Current American Stroke Association guidelines recommend initiating intravenous thrombolysis (IVT) for acute ischemic stroke (AIS) within 60min of patient arrival, given the benefits of IVT for AIS are time dependent. This study aimed to identify the delaying factors in door-to-needle time (DTN) in the emergency department of one of the largest comprehensive stroke centers in New York State. We also recommended measures to reduce the delays. METHODS: We retrospectively reviewed the medical charts of all AIS patients who received IVT in our emergency department patients between April 1, 2012 and December 31, 2015 to identify those with a DTN time of >60min...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28429359/the-role-of-angiogenesis-inhibitors-re-challenge-in-colorectal-cancer-previously-treated-with-bevacizumab-a-meta-analysis-of-randomized-controlled-trials
#4
Y-X Xiong, L Ren, Z-Q Wang, X-W Huang, Y-J Zhou
OBJECTIVE: The potential usefulness of angiogenesis inhibitors (AIs) re-challenge in the treatment of metastatic colorectal cancer (CRC) who previously treated with bevacizumab has not been established yet. MATERIALS AND METHODS: We identified relevant clinical studies through searching databases up to October 2016. Prospective clinical trials investigating AIs re-challenge in metastatic CRC were included for analysis. The primary endpoint was overall survival with secondary endpoint progression-free survival...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28428982/biomechanical-effect-of-pedicle-screw-distribution-in-ais-instrumentation-using-a-segmental-translation-technique-computer-modeling-and-simulation
#5
Xiaoyu Wang, A Noelle Larson, Dennis G Crandall, Stefan Parent, Hubert Labelle, Charles G T Ledonio, Carl-Eric Aubin
BACKGROUND: Efforts to select the appropriate number of implants in adolescent idiopathic scoliosis (AIS) instrumentation are hampered by a lack of biomechanical studies. The objective was to biomechanically evaluate screw density at different regions in the curve for AIS correction to test the hypothesis that alternative screw patterns do not compromise anticipated correction in AIS when using a segmental translation technique. METHODS: Instrumentation simulations were computationally performed for 10 AIS cases...
2017: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/28428081/intraoperative-image-guidance-compared-with-free-hand-methods-in-adolescent-idiopathic-scoliosis-posterior-spinal-surgery-a-systematic-review-on-screw-related-complications-and-breach-rates
#6
Andrew Chan, Eric Parent, Karl Narvacan, Cindy San, Edmond Lou
BACKGROUND CONTEXT: Severe adolescent idiopathic scoliosis (AIS) is a 3D spinal deformity requiring surgery to stop curve progression. Posterior spinal instrumentation and fusion with pedicle screws is the standard surgery for AIS curve correction. Vascular and neurologic complications related to screw-malpositioning are concerns in surgeries for AIS. Breach rates are reported at 15.7%, implant-related complications at 1.1% and neurologic deficit at 0.8%. Free-hand screw insertion remains the prevailing method of screw placement while image guidance has been suggested to improve placement accuracy...
April 17, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28427480/lessons-from-a-large-trauma-center-impact-of-blunt-chest-trauma-in-polytrauma-patients-still-a-relevant-problem
#7
REVIEW
Konstantina Chrysou, Gabriel Halat, Beatrix Hoksch, Ralph A Schmid, Gregor J Kocher
BACKGROUND: Thoracic trauma is the third most common cause of death after abdominal injury and head trauma in polytrauma patients. The purpose of this study was to investigate epidemiological data, treatment and outcome of polytrauma patients with blunt chest trauma in order to help improve management, prevent complications and decrease polytrauma patients' mortality. METHODS: In this retrospective study we included all polytrauma patients with blunt chest trauma admitted to our tertiary care center emergency department for a 2-year period, from June 2012 until May 2014...
April 20, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28425069/a-prospective-serial-mri-study-following-acute-traumatic-cervical-spinal-cord-injury
#8
Joost P H J Rutges, Brian K Kwon, Manraj Heran, Tamir Ailon, John T Street, Marcel F Dvorak
PURPOSE: In acute traumatic cervical spinal cord injury (SCI) patients, we sought to characterize how objective MRI measures of injury change during the first 3 week post-injury. METHODS: Six MRI scans each were planned in 19 cervical SCI patients within the first 3 week post-injury. Length of cord edema, maximum spinal cord compression, maximum canal compromise, and presence and length of hematoma were measured. RESULTS: Length of spinal cord edema increased in the first 48 h after SCI, followed by a gradual decrease in the 3 weeks after injury...
April 19, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28424274/copeptin-and-nt-probnp-for-prediction-of-all-cause-and-cardiovascular-death-in-ischemic-stroke
#9
Wen-Jun Tu, Guo-Zhao Ma, Ying Ni, Xia-Sheng Hu, Ding-Zhen Luo, Xian-Wei Zeng, Qiang Liu, Tingting Xu, Lie Yu, Boshui Wu
OBJECTIVE: To evaluate long-term mortality in patients with acute ischemic stroke (AIS) by exploring the correlation between death and plasma concentrations of copeptin and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in a cohort study. METHODS: In a prospective, multicenter observational study of 4,215 patients with AIS, copeptin and NT-proBNP levels were measured with a standardized method when patients were admitted to hospital. The primary endpoint was all-cause mortality or cardiovascular disease (CVD) mortality within 1 year...
April 19, 2017: Neurology
https://www.readbyqxmd.com/read/28420316/persistence-of-secondary-prevention-medication-and-related-factors-for-acute-ischemic-stroke-and-transient-ischemic-attack-in-china
#10
Yue Jiang, Xiaomeng Yang, Zixiao Li, Yuesong Pan, Yilong Wang, Yongjun Wang, Ruijun Ji, Chen Wang
OBJECTIVE: We recently measured the longitudinal use of secondary prevention medication following hospital discharge and the factors influencing persistence in patients with acute ischemic stroke (AIS) and transient ischemic attack (TIA) in China. METHODS: Patients with AIS and TIA who were enrolled in the China National Stroke Registry II from June 2012 to January 2013 were surveyed to determine persistence. The medications included antiplatelet therapies, warfarin, antihypertensive therapies, statins, and diabetes medications...
April 19, 2017: Neurological Research
https://www.readbyqxmd.com/read/28419989/admission-low-magnesium-level-is-associated-with-in-hospital-mortality-in-acute-ischemic-stroke-patients
#11
Shoujiang You, Chongke Zhong, Huaping Du, Yu Zhang, Danni Zheng, Xia Wang, Chenhong Qiu, Hongru Zhao, Yongjun Cao, Chun-Feng Liu
BACKGROUND: Low magnesium levels are associated with an elevated risk of stroke. In this study, we investigated the association between magnesium levels on hospital admission and in-hospital mortality in acute ischemic stroke (AIS) patients. METHODS: A total of 2,485 AIS patients, enrolled from December 2013 to May 2014 across 22 hospitals in Suzhou city, were included in this study. The patients were divided into 4 groups according to their level of admission magnesium: Q1 (<0...
April 19, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28418395/an-analysis-of-ideal-and-actual-time-to-surgery-after-traumatic-spinal-cord-injury-in-canada
#12
R A Glennie, C S Bailey, E C Tsai, V K Noonan, C S Rivers, D R Fourney, H Ahn, B K Kwon, J Paquet, B Drew, M G Fehlings, N Attabib, S D Christie, J Finkelstein, R J Hurlbert, S Parent, M F Dvorak
STUDY DESIGN: Retrospective analysis of a prospective registry and surgeon survey. OBJECTIVES: To identify surgeon opinion on ideal practice regarding the timing of decompression/stabilization for spinal cord injury and actual practice. Discrepancies in surgical timing and barriers to ideal timing of surgery were explored. SETTING: Canada. METHODS: Patients from the Rick Hansen Spinal Cord Registry (RHSCIR, 2004-2014) were reviewed to determine actual timing of surgical management...
April 18, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28418040/the-height-width-depth-ratios-of-the-intervertebral-discs-and-vertebral-bodies-in-adolescent-idiopathic-scoliosis-vs-controls-in-a-chinese-population
#13
Hao Chen, Tom P C Schlösser, Rob C Brink, Dino Colo, Marijn van Stralen, Lin Shi, Winnie C W Chu, Pheng-Ann Heng, René M Castelein, Jack C Y Cheng
Adolescent idiopathic scoliosis (AIS) patients have been reported to be taller and more slender than normal controls, suggesting less mechanical stiffness of their trunk and spine. For assessment of mechanical stiffness, to our best knowledge this is the first to study height-width-depth relations at the level of the individual vertebra and disc in 3-D and to evaluate its relation with the Cobb angle severity. A unique series of high-resolution pre-operative computed tomographic (CT) scans of a total of 105 Chinese patients with moderate to severe AIS and 11 age-matched non-scoliotic controls were used for this study...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28414745/mapping-the-srs-22r-questionnaire-onto-the-eq-5d-5l-utility-score-in-patients-with-adolescent-idiopathic-scoliosis
#14
Carlos King Ho Wong, Prudence Wing Hang Cheung, Dino Samartzis, Keith Dip-Kei Luk, Kenneth M C Cheung, Cindy Lo Kuen Lam, Jason Pui Yin Cheung
This is a prospective study to establish prediction models that map the refined Scoliosis Research Society 22-item (SRS-22r) onto EuroQoL-5 dimension 5-level (EQ-5D-5L) utility scores in adolescent idiopathic scoliosis (AIS) patients. Comparison of treatment outcomes in AIS can be determined by cost-utility analysis. However, the mainstay spine-specific health-related quality of life outcome measure, the SRS-22r questionnaire does not provide utility assessment. In this study, AIS patients were prospectively recruited to complete both the EQ-5D-5L and SRS-22r questionnaires by trained interviewers...
2017: PloS One
https://www.readbyqxmd.com/read/28409234/clinical-role-of-von-willebrand-factor-in-acute-ischemic-stroke
#15
Marija Menih, Miljenko Križmarić, Tanja Hojs Fabjan
BACKGROUND: An elevated level of von Willebrand factor (VWF) is associated with an increased risk for coronary heart disease and ischemic stroke. The objective of the study was to determine whether the level of VWF is associated with the cardioembolic subtype of ischemic stroke, stroke severity, and clinical outcome. PATIENTS AND METHODS: In this study 108 patients suffering from acute ischemic stroke (AIS) were included. According to the etiology of the stroke, patients were classified into the subtype of cardioembolic (CE) stroke and the group with non-CE stroke...
April 13, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28407385/effect-of-formalin-fixation-and-tumor-size-in-small-sized-non-small-cell-lung-cancer-a-prospective-single-center-study
#16
Heae Surng Park, Sungsoo Lee, Seokjin Haam, Geun Dong Lee
AIM: Formalin fixation can cause tumor shrinkage. We prospectively evaluated the effect of overnight formalin fixation on tumor size and the effect of clinicopathological parameters on changes in tumor size in small-sized non-small cell lung cancer (NSCLC). METHODS AND RESULTS: Our study included 126 surgically resected NSCLC specimens submitted in a fresh state. We measured the largest cross-sectional tumor diameters in the fresh and formalin-fixed specimens. Tumor size significantly differed (mean, 0...
April 13, 2017: Histopathology
https://www.readbyqxmd.com/read/28407025/relationships-between-temperaments-occupational-stress-and-insomnia-among-japanese-workers
#17
Yasuhiko Deguchi, Shinichi Iwasaki, Hideyuki Ishimoto, Koichiro Ogawa, Yuichi Fukuda, Tomoko Nitta, Tomoe Mitake, Yukako Nogi, Koki Inoue
Insomnia among workers reduces the quality of life, contributes toward the economic burden of healthcare costs and losses in work performance. The relationship between occupational stress and insomnia has been reported in previous studies, but there has been little attention to temperament in occupational safety and health research. The aim of this study was to clarify the relationships between temperament, occupational stress, and insomnia. The subjects were 133 Japanese daytime local government employees...
2017: PloS One
https://www.readbyqxmd.com/read/28406159/sensitivity-and-accuracy-of-high-throughput-metabarcoding-methods-for-early-detection-of-invasive-fish-species
#18
Chelsea Hatzenbuhler, John R Kelly, John Martinson, Sara Okum, Erik Pilgrim
High-throughput DNA metabarcoding has gained recognition as a potentially powerful tool for biomonitoring, including early detection of aquatic invasive species (AIS). DNA based techniques are advancing, but our understanding of the limits to detection for metabarcoding complex samples is inadequate. For detecting AIS at an early stage of invasion when the species is rare, accuracy at low detection limits is key. To evaluate the utility of metabarcoding in future fish community monitoring programs, we conducted several experiments to determine the sensitivity and accuracy of routine metabarcoding methods...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28404769/a-decrease-in-blood-pressure-is-associated-with-unfavorable-outcome-in-patients-undergoing-thrombectomy-under-general-anesthesia
#19
Kilian M Treurniet, Olvert A Berkhemer, Rogier V Immink, Hester F Lingsma, Vivian M C Ward-van der Stam, Markus W Hollmann, Jaap Vuyk, Wim H van Zwam, Aad van der Lugt, Robert J van Oostenbrugge, Diederik W J Dippel, Jonathan M Coutinho, Yvo B W E M Roos, Henk A Marquering, Charles B L M Majoie
BACKGROUND: Up to two-thirds of patients are either dependent or dead 3 months after thrombectomy for acute ischemic stroke (AIS). Loss of cerebral autoregulation may render patients with AIS vulnerable to decreases in mean arterial pressure (MAP). OBJECTIVE: To determine whether a fall in MAP during intervention under general anesthesia (GA) affects functional outcome. METHODS: This subgroup analysis included patients from the MR CLEAN trial treated with thrombectomy under GA...
April 12, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28403493/-acute-idiopathic-scrotal-oedema-differential-diagnosis-of-the-acute-scrotum
#20
Annette Schröder
Acute idiopathic scrotal edema (AISE) is regarded as a rare cause of scrotal pain, swelling and erythema. Testicular torsion, torsion of the appendage, epididymitis, hernia and hydrocele are the most common causes of acute scrotum. The clinical symptoms of AISE are usually mild and the characteristic Doppler sonography findings make it a valuable differential diagnosis, which can help to avoid unnecessary exploration.
February 2017: Aktuelle Urologie
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