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https://www.readbyqxmd.com/read/28931176/the-role-of-cortisol-acth-ratio-for-screening-of-subclinical-hypercortisolism-in-patients-with-adrenal-incidentalomas
#1
Lele Li, Guoqing Yang, Jingtao Dou, Weijun Gu, Zhaohui Lv, Juming Lu, Yiming Mu
Introduction The cortisol/ACTH ratio was supposed to be helpful in the screening of subclinical hypercortisolism (SHC) in the published literatures. This study assessed the cortisol/ACTH ratio in patients with adrenal incidentaloma (AI) confirmed to have SHC and investigated its role for screening SCS in patients with AI. Methods This descriptive retrospective study included 183 patients with AIs [45 with SHC and 138 with non-functional adenoma (NFA)]. Cortisol and ACTH levels were measured at 8:00, 16:00, and 0:00, and the cortisol/ACTH ratio was calculated...
September 20, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28930941/thoracic-irrigation-prevents-retained-hemothorax-a-prospective-propensity-scored-analysis
#2
Nathan W Kugler, Thomas W Carver, David Milia, Jasmeet S Paul
BACKGROUND: Thoracic trauma resulting in hemothorax (HTx) is typically managed with thoracostomy tube (TT) placement; however, up to 20% of patients develop retained HTx which may necessitate further intervention for definitive management. While optimal management of retained HTx has been extensively researched, little is known about prevention of this complication. We hypothesized thoracic irrigation at the time of TT placement would significantly decrease the rate of retained HTx necessitating secondary intervention...
September 20, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28930855/distal-adding-on-phenomenon-in-adolescent-idiopathic-scoliosis-patients-with-thoracolumbar-vertebra-fusion-a-case-control-study
#3
Wei Xu, Chao Chen, Yifan Li, Changwei Yang, Ming Li, Zhikun Li, Xiaodong Zhu
The adding-on phenomenon is a common complication in adolescent idiopathic scoliosis (AIS) patients after correction surgery. However, the risk factors of previous studies and the optimal treatment strategies remain controversial. The aim of this study was to identify new risk factors for the adding-on phenomenon after posterior correction surgery in AIS patients and compare different treatment strategies to guide the selection of the lowest instrumented vertebra (LIV).All types of Lenke AIS patients who received correction surgery at our center from January 2009 to July 2014 were analyzed...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28929919/evaluating-the-efficacy-of-functional-electrical-stimulation-therapy-assisted-walking-after-chronic-motor-incomplete-spinal-cord-injury-effects-on-bone-biomarkers-and-bone-strength
#4
B Catharine Craven, Lora M Giangregorio, S Mohammad Alavinia, Lindsie A Blencowe, Naaz Desai, Sander L Hitzig, Kei Masani, Milos R Popovic
To determine the efficacy of functional electrical stimulation therapy assisted walking (FES-T) compared to a conventional aerobic and resistance training (CONV) with respect to bone biomarkers and lower extremity bone strength outcomes among adults with chronic motor incomplete spinal cord injury (SCI). Design Parallel group randomized controlled trial ( www.clinicaltrials.gov - NCT0020196819). Site Tertiary academic rehabilitation centre in Canada. Methods Adults with chronic (≥18 months) motor incomplete SCI (C2-T12 AIS C-D) were consented and randomized to FES-T or CONV training for 45 minutes thrice-weekly for 4 months...
September 20, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28929913/development-of-acute-promyelocytic-leukemia-in-a-patient-with-tetraplegia-while-in-inpatient-rehabilitation-a-case-report
#5
Christopher A Beal, Michael C Krouse, Jeffrey T Tubbs
STUDY DESIGN: a single case report. OBJECTIVES: To report a case of a patient with tetraplegia who developed acute promyelocytic leukemia (APL) while in inpatient rehabilitation after 10.5 months. SETTING: A VA Medical Center Spinal Cord Injury Service and Disorders Unit Case Report: A 47 year-old male with a stage IV sacral pressure ulcer and C4 AIS A complete tetraplegia secondary to a motor vehicle collision, developed fever, thrombocytopenia, and anemia 20 months after his injury while in inpatient rehabilitation and was found to have APL, confirmed following bone marrow biopsy...
September 20, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28929697/-effects-of-berberine-on-serum-inflammatory-factors-and-carotid-atherosclerotic-plaques-in-patients-with-acute-cerebral-ischemic-stroke
#6
Ying Li, Pei Wang, Mei-Jing Chai, Fan Yang, Hong-Shan Li, Jing Zhao, Huan Wang, Dan-Dan Lu
This study aims to analyze the effect of berberine on serum inflammatory factors and carotid atherosclerotic plaques in ppatients with acute cerebral ischemic stroke(AIS). In the study, 120 patients with AIS were randomly divided into berberine group(n=60) and general group (n=60). The 60 cases in the general group were provided with general therapy according to the latest guidelines of diagnosis and treatment of AIS. The berberine group received berberine 300 mg(tid) in addition to the therapy of the general group...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28927686/temporal-trends-in-the-levels-of-peripherally-circulating-leukocyte-subtypes-in-the-hours-after-ischemic-stroke
#7
Dipender Gill, Prasanthi Sivakumaran, Adarsh Aravind, Atisha Tank, Roshni Dosh, Roland Veltkamp
BACKGROUND: Leukocyte-mediated neuroinflammation may affect outcomes after ischemic stroke. AIMS: To explore temporal changes in levels of peripherally circulating leukocyte subtypes in the early hours after ischemic stroke in humans. METHODS: Retrospective analysis of a single-center database of consecutive thrombolysis cases for acute ischemic stroke (AIS). Multivariable regression analysis was used to explore temporal changes in the levels of peripherally circulating leukocyte subtypes in the hours immediately after ischemic stroke...
September 15, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28926940/stress-exposure-and-physical-mental-and-behavioral-health-among-american-indian-adults-with-type-2-diabetes
#8
Melissa L Walls, Kelley J Sittner, Benjamin D Aronson, Angie K Forsberg, Les B Whitbeck, Mustafa al'Absi
American Indian (AI) communities experience disproportionate exposure to stressors and health inequities including type 2 diabetes. Yet, we know little about the role of psychosocial stressors for AI diabetes-related health outcomes. We investigated associations between a range of stressors and psychological, behavioral, and physical health for AIs with diabetes. This community-based participatory research with 5 AI tribes includes 192 AI adult type 2 diabetes patients recruited from clinical records at tribal clinics...
September 16, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28926936/relationships-of-sexual-dysfunction-with-depression-and-acceptance-of-illness-in-women-and-men-with-type-2-diabetes-mellitus
#9
Ewelina Bąk, Czeslaw Marcisz, Sylwia Krzemińska, Dorota Dobrzyn-Matusiak, Agnieszka Foltyn, Agnieszka Drosdzol-Cop
An increased prevalence of sexual disorders has been reported in patients with type 2 diabetes. The aim of this study is the assessment of the influence of the psychical condition, the concentration of glycated hemoglobin, the duration of diabetes, the body mass index, the age, and the subjective acceptance of the illness on sexual disorders occurring in women and men with type 2 diabetes. The study enrolled 215 patients (114 women and 101 men) with type 2 diabetes and 183 controls. Sexuality was determined in all of the studied subjects using: the Female Sexual Function Index (FSFI) in women and the International Index of Erectile Function (IIEF) in men...
September 16, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28926823/preparation-characterization-and-application-of-urease-nanoparticles-for-construction-of-an-improved-potentiometric-urea-biosensor
#10
Seema Jakhar, C S Pundir
The nanoparticles (NPs) aggregates of commercial urease from jack beans (Canavalia ensiformis) were prepared by desolvation and glutaraldehyde crosslinking and functionalized by cysteamine dihydrochloride. These enzyme nanoparticles (ENPs) were characterized by transmission electron microscopy (TEM), UV and Fourier transform infrared (FTIR) spectroscopy. The TEM images of urease NPs showed their size in the range, 18-100nm with an average of 51.2nm. The ENPs were more active and stable with a longer shelf life than native enzyme molecules...
September 6, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28924353/respiratory-muscle-strength-in-idiopathic-scoliosis-after-training-program
#11
Vera Lúcia Dos Santos Alves, Osmar Avanzi
OBJECTIVE: To analyze the impact of a physiotherapy protocol in maximum inspiratory and expiratory pressure in patients with adolescent idiopathic scoliosis (AIS) by manovacuometry. AIS may change the respiratory dynamics and the performance of inspiratory and expiratory muscles, affecting ventilatory capacity. METHODS: Patients with AIS aged 10 to 20 years old were randomly assigned to receive an aerobic exercise-training program or no treatment. They were evaluated for respiratory muscle strength before and after the treatment period by means of manovacuometry, thorax and spine radiographs...
November 2016: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/28923240/national-survey-on-perioperative-anaesthetic-management-in-the-endovascular-treatment-of-acute-ischaemic-stroke
#12
O Romero Kräuchi, L Valencia, F Iturri, A Mariscal Ortega, A López Gómez, R Valero
OBJECTIVE: To assess the anaesthetic management of treatment for endovascular acute ischaemic stroke (AIS) in Spain. MATERIALS AND METHOD: A survey was designed by the SEDAR Neuroscience Section and sent to the Spanish anaesthesiology departments with a primary stroke centre between July and November 2016. RESULTS: Of the 47 hospitals where endovascular treatment of AIS is performed, 37 anaesthesiology departments participated. Thirty responses were obtained; three of which were eliminated due to duplication (response rate of 72...
September 15, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/28922860/structural-plasticity-of-synaptopodin-in-the-axon-initial-segment-during-visual-cortex-development
#13
Annabelle Schlüter, Domenico Del Turco, Thomas Deller, Annika Gutzmann, Christian Schultz, Maren Engelhardt
The axon initial segment (AIS) is essential for action potential generation. Recently, the AIS was identified as a site of neuronal plasticity. A subpopulation of AIS in cortical principal neurons contains stacks of endoplasmic reticulum (ER) forming the cisternal organelle (CO). The function of this organelle is poorly understood, but roles in local Ca2+-trafficking and AIS plasticity are discussed. To investigate whether the presence and/or the size of COs are linked to the development and maturation of AIS of cortical neurons, we analyzed the relationship between COs and the AIS during visual cortex development under control and visual deprivation conditions...
September 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28922781/toxicity-of-extended-adjuvant-therapy-with-aromatase-inhibitors-in-early-breast-cancer-a-systematic-review-and-meta-analysis
#14
Hadar Goldvaser, Tristan A Barnes, Boštjan Šeruga, David W Cescon, Alberto Ocaña, Domen Ribnikar, Eitan Amir
Background: A number of randomized controlled trials (RCTs) have reported improvement in breast cancer outcomes from extending treatment with aromatase inhibitors (AIs) beyond the initial five years after diagnosis. However, the toxicity profile of extended AIs is uncertain. Methods: We identified RCTs that compared extended AIs to placebo or no treatment using MEDLINE and a review of abstracts from key conferences between 2013 and 2016. Odds ratios (ORs), 95% confidence intervals (CIs), absolute risks, and the number needed to harm (NNH) were computed for prespecified safety and tolerability outcomes including cardiovascular events, bone fractures, second cancers (excluding new breast cancer), treatment discontinuation for adverse events, and death without recurrence...
January 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28920082/is-a-persistent-central-canal-a-risk-factor-for-neurological-injury-in-patients-undergoing-surgical-correction-of-scoliosis
#15
Steven Kyriacou, Yuen Man, Karen Plumb, Matthew Shaw, Kia Rezajooi
BACKGROUND: Scoliosis patients with associated syringomyelia are at an increased risk of neurological injury during surgical deformity correction. The syrinx is therefore often addressed surgically prior to scoliosis correction to minimize this risk. It remains unclear if the presence of a persistent central canal (PCC) within the spinal cord also poses a similar risk. The aim of this study is to determine whether there is any evidence to suggest that patients with a PCC are also at a higher risk of neurological injury during surgical scoliosis correction...
2017: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/28920070/prevalence-and-associated-factors-of-acute-traumatic-coagulopathy-a-cross-sectional-study
#16
Hojjat Derakhshanfar, Ali Vafaei, Ali Tabatabaey, Shamila Noori
INTRODUCTION: Acute traumatic coagulopathy (ATC) is defined as having evidence of coagulopathy in patients with severe trauma. The aim of this preliminary study was to assess the prevalence and associated factors of ATC in severely traumatic patients presenting to emergency department (ED). METHODS: In this retrospective cross sectional study, all patients with severe traumatic injury and available coagulation profile, presenting to the EDs of two major trauma centers in Tehran, Iran, during one year, were studied...
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/28919982/effective-management-of-spasticity-and-impacts-on-weight-change-and-resting-energy-expenditure-in-a-female-with-spinal-cord-injury-a-case-report
#17
Amy N Nevin, Khanh Nguyen, Sridhar Atresh, Angela Vivanti, Ingrid J Hickman
INTRODUCTION: The impact of muscle spasticity on weight change and energy expenditure after spinal cord injury (SCI) is not well understood. CASE PRESENTATION: This case study reports changes to body weight and resting energy expenditure (REE) in a 36-year-old female (T3 AIS A SCI; 80 kg; body mass index=28 kg m(-)(2) at injury) requiring escalating therapies to manage severe spasticity. Body weight, spasticity medications and fasted REE (measured using indirect calorimetry, canopy hood) were recorded at 4, 16, 17, 20 and 44 months post injury...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28918086/confidence-in-the-use-of-direct-oral-anticoagulants-in-the-acute-phase-of-nonvalvular-atrial-fibrillation-related-ischemic-stroke-over-the-years-a-real-world-single-center-study
#18
Federico Moroni, Luca Masotti, Vieri Vannucchi, Raffaella Chiarelli, Cristiana Seravalle, Alessandra Pesci, Francesca Pallini, Silvia Puliti, Barbara Cimolato, Lamberto Fattorini, Cornelia Scerra, Francesca Ristori, Maria Letizia Imbalzano, Stefano Spolveri, Giancarlo Landini, Elisa Grifoni, Maurizio Paciaroni
BACKGROUD AND AIM: The use of direct oral anticoagulants (DOACs) in patients with nonvalvular atrial fibrillation (NVAF)-related acute ischemic stroke (AIS) is controversial. The aims of our study were to analyze physicians' confidence in prescribing DOACs in NVAF-related AIS, the characteristics of patients receiving DOACs, and their 90-day prognosis. MATERIAL AND METHODS: Clinical records of consecutive patients admitted to our wards for NVAF-related AIS over the years 2014-2016 were reviewed...
September 13, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28916347/boat-anchoring-pressure-on-coastal-seabed-quantification-and-bias-estimation-using-ais-data
#19
Julie Deter, Xavier Lozupone, Adrien Inacio, Pierre Boissery, Florian Holon
Global shipping is economically important, but has many adverse environmental effects. Anchoring contributes greatly to this adverse impact, as it is responsible for mechanical disturbance of highly sensitive marine habitats. Recovery of these ecosystems is limited by slow regrowth. Anchoring pressure on coastal seabed habitats was estimated using AIS (Automatic Identification System) data along 1800km of Mediterranean coastline between 2010 and 2015. A comparison with field observations showed that these results were most consistent for large boats (>50m)...
September 12, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28913606/ranges-of-injury-risk-associated-with-impact-from-unmanned-aircraft-systems
#20
Eamon T Campolettano, Megan L Bland, Ryan A Gellner, David W Sproule, Bethany Rowson, Abigail M Tyson, Stefan M Duma, Steven Rowson
Regulations have allowed for increased unmanned aircraft systems (UAS) operations over the last decade, yet operations over people are still not permitted. The objective of this study was to estimate the range of injury risks to humans due to UAS impact. Three commercially-available UAS models that varied in mass (1.2-11 kg) were evaluated to estimate the range of risk associated with UAS-human interaction. Live flight and falling impact tests were conducted using an instrumented Hybrid III test dummy. On average, live flight tests were observed to be less severe than falling impact tests...
September 14, 2017: Annals of Biomedical Engineering
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