Y Hayashi, Y Mori, O E Janssen, T Sunthornthepvarakul, R E Weiss, K Takeda, M Weinberg, H Seo, G I Bell, S Refetoff
T4-binding globulin (TBG) is a glycoprotein of hepatic origin which transports thyroid hormone in serum. To characterize the human TBG (hTBG) gene, we studied its genomic organization, promoter activity, and regulation. To this purpose, we isolated from liver a complete hTBG cDNA clone containing the 5'-untranslated region and localized the transcription start site (TSS). The analysis of genomic clones revealed that the hTBG gene consists of five exons and that its exon-intron organization is similar to that of other members of the serine protease inhibitor family...
August 1993: Molecular Endocrinology