keyword
https://read.qxmd.com/read/38506325/macro-and-microvascular-contributions-to-cerebral-structural-alterations-in-patients-with-asymptomatic-carotid-artery-stenosis
#21
JOURNAL ARTICLE
Lena Schmitzer, Stephan Kaczmarz, Jens Göttler, Gabriel Hoffmann, Michael Kallmayer, Hans-Henning Eckstein, Dennis Martin Hedderich, Jan Kufer, Claus Zimmer, Christine Preibisch, Fahmeed Hyder, Nico Sollmann
Atherosclerosis can underly internal carotid artery stenosis (ICAS), a major risk factor for ischemic stroke, as well as small vessel disease (SVD). This study aimed to investigate hemodynamics and structural alterations associated with SVD in ICAS patients. 28 patients with unilateral asymptomatic ICAS and 30 age-matched controls underwent structural (T1-/T2-weighted and diffusion tensor imaging [DTI]) and hemodynamic (pseudo-continuous arterial spin labeling and dynamic susceptibility contrast) magnetic resonance imaging...
March 20, 2024: Journal of Cerebral Blood Flow and Metabolism
https://read.qxmd.com/read/38500925/association-between-head-computed-tomography-findings-and-in-hospital-mortality-in-covid-19-patients
#22
JOURNAL ARTICLE
Kensaku Yoshida, Mikio Nakajima, Richard H Kaszynski, Masayoshi Horino, Takuma Higo
OBJECTIVE: The present study investigated the association between head computed tomography (CT) findings and mortality in patients with COVID-19. Specifically, we focused on low-density lesions identified on head CT screenings. MATERIALS AND METHODS: We performed a single-center, retrospective cohort study based on data obtained from the medical charts of inpatients admitted to the Tokyo Metropolitan Hiroo Hospital between January 1 and December 31, 2021. We focused on the basal ganglia--a representative anatomical region for assessing routine head CT in patients with COVID-19...
February 2024: Curēus
https://read.qxmd.com/read/38497722/assessment-of-small-vessel-function-using-7t-mri-in-patients-with-sporadic-cerebral-small-vessel-disease-the-zoom-svds-study
#23
JOURNAL ARTICLE
Hilde Van Den Brink, Stanley Pham, Jeroen C Siero, Tine Arts, Laurien Onkenhout, Hugo Kuijf, Jeroen Hendrikse, Joanna M Wardlaw, Martin Dichgans, Jaco J Zwanenburg, Geert Jan Biessels
BACKGROUND AND OBJECTIVES: Cerebral small vessel disease (cSVD) is a major cause of stroke and dementia, but little is known about disease mechanisms at the level of the small vessels. 7T-MRI allows assessing small vessel function in vivo in different vessel populations. We hypothesized that multiple aspects of small vessel function are altered in patients with cSVD and that these abnormalities relate to disease burden. METHODS: Patients and controls participated in a prospective observational cohort study, the ZOOM@SVDs study...
March 12, 2024: Neurology
https://read.qxmd.com/read/38495305/enlarged-perivascular-spaces-are-associated-with-white-matter-injury-cognition-and-inflammation-in-cerebral-autosomal-dominant-arteriopathy-with-subcortical-infarcts-and-leukoencephalopathy
#24
JOURNAL ARTICLE
Nikolaos Karvelas, Bradley Oh, Earnest Wang, Yann Cobigo, Torie Tsuei, Stephen Fitzsimons, Kyan Younes, Alexander Ehrenberg, Michael D Geschwind, Daniel Schwartz, Joel H Kramer, Adam R Ferguson, Bruce L Miller, Lisa C Silbert, Howard J Rosen, Fanny M Elahi
Enlarged perivascular spaces have been previously reported in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, but their significance and pathophysiology remains unclear. We investigated associations of white matter enlarged perivascular spaces with classical imaging measures, cognitive measures and plasma proteins to better understand what enlarged perivascular spaces represent in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy and whether radiographic measures of enlarged perivascular spaces would be of value in future therapeutic discovery studies for cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy...
2024: Brain communications
https://read.qxmd.com/read/38495303/prevalence-and-imaging-characteristics-of-cerebral-small-vessel-disease-in-a-colombian-population-aged-40-years-and-older
#25
JOURNAL ARTICLE
Laura Rodriguez, Ana T Araujo, Daniela D Vera, Adriana Rodríguez Gelvez, Paul A Camacho, Daniel E Mantilla, Juan C Mantilla
Cerebral small vessel disease is a major contributor to both brain aging and cognitive decline. This study aimed to determine the prevalence of cerebral small vessel disease in a Colombian population over 40 years of age who attended a Radiology and Diagnostic Imaging service for brain MRI between October 2018 and March 2019. This was an observational, cross-sectional and analytical study of 710 adult patients over 40 years of age who attended the Radiology and Diagnostic Imaging service for a brain MRI. The analysed data were obtained from an anonymized database of the service...
2024: Brain communications
https://read.qxmd.com/read/38491107/hypertension-facilitates-age-related-diseases-is-hypertension-associated-with-a-wide-variety-of-diseases
#26
REVIEW
Masaki Mogi, Yasuhito Ikegawa, Shunsuke Haga, Satoshi Hoshide, Kazuomi Kario
Hypertension, a disease whose prevalence increases with age, induces pathological conditions of ischemic vascular disorders such as cerebral infarction and myocardial infarction due to accelerated arteriosclerosis and circulatory insufficiency of small arteries and sometimes causes hemorrhagic conditions such as cerebral hemorrhage and ruptured aortic aneurysm. On the other hand, as it is said that aging starts with the blood vessels, impaired blood flow associated with vascular aging is the basis for the development of many pathological conditions, and ischemic changes in target organs associated with vascular disorders result in tissue dysfunction and degeneration, inducing organ hypofunction and dysfunction...
March 15, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/38489688/cerebral-autosomal-dominant-arteriopathy-with-subcortical-infarcts-and-leukoencephalopathy-cadasil-with-multiple-different-onset-forms-of-frequent-recurrent-attacks-a-case-report-and-literature-review
#27
JOURNAL ARTICLE
Siting Wu, Ning Zhao, Tingting Sun, Fang Cui, Xianli Sun, Jiacai Lin
INTRODUCTION: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is one kind of monogenic hereditary small-vessel disease in the brain caused by mutations in the NOTCH3 gene. However, it is rare for CADASIL to recur with different clinical manifestations in 1 patient, and some atypical clinical manifestations can easily lead to misdiagnosis by clinical physicians. CASE CONCERN: A 34-year-old male presented with transient speech disorder accompanied by weakness in the left side of the body for 1 day in June 2020...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38487075/risk-factors-and-cognitive-correlates-of-white-matter-hyperintensities-in-ethnically-diverse-populations-without-dementia-the-cosmic-consortium
#28
JOURNAL ARTICLE
Keshuo Lin, Wei Wen, Darren M Lipnicki, Louise Mewton, Rory Chen, Jing Du, Dadong Wang, Ingmar Skoog, Therese Rydberg Sterner, Jenna Najar, Ki Woong Kim, Ji Won Han, Jun Sung Kim, Tze Pin Ng, Roger Ho, Denise Qian Ling Chua, Kaarin J Anstey, Nicolas Cherbuin, Moyra E Mortby, Henry Brodaty, Nicole Kochan, Perminder S Sachdev, Jiyang Jiang
INTRODUCTION: White matter hyperintensities (WMHs) are an important imaging marker for cerebral small vessel diseases, but their risk factors and cognitive associations have not been well documented in populations of different ethnicities and/or from different geographical regions. METHODS: We investigated how WMHs were associated with vascular risk factors and cognition in both Whites and Asians, using data from five population-based cohorts of non-demented older individuals from Australia, Singapore, South Korea, and Sweden ( N  = 1946)...
2024: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/38481159/chronic-kidney-disease-and-its-association-with-cerebral-small-vessel-disease-in-the-general-older-hypertensive-population
#29
JOURNAL ARTICLE
Tomas Månsson, Aldana Rosso, Katarina Ellström, Kasim Abul-Kasim, Sölve Elmståhl
BACKGROUND: Cerebral small vessel disease can be identified using magnetic resonance imaging, and includes white matter hyperintensities, lacunar infarcts, cerebral microbleeds, and brain atrophy. Cerebral small vessel disease and chronic kidney disease share many risk factors, including hypertension. This study aims to explore an association between chronic kidney disease and cerebral small vessel disease, and also to explore the role of hypertension in this relationship. METHODS: With a cross sectional study design, data from 390 older adults was retrieved from the general population study Good Aging in Skåne...
March 13, 2024: BMC Nephrology
https://read.qxmd.com/read/38477113/visit-to-visit-blood-pressure-variability-and-progression-of-white-matter-hyperintensities-over-14-years
#30
JOURNAL ARTICLE
Esther Janssen, Jan Willem van Dalen, Mengfei Cai, Mina A Jacob, José Marques, Marco Duering, Edo Richard, Anil M Tuladhar, Frank-Erik de Leeuw, Nina Hilkens
Purpose: There is evidence that blood pressure variability (BPV) is associated with cerebral small vessel disease (SVD) and may therefore increase the risk of stroke and dementia. It remains unclear if BPV is associated with SVD progression over years. We examined whether visit-to-visit BPV is associated with white matter hyperintensity (WMH) progression over 14 years and MRI markers after 14 years. Materials and methods: We included participants with SVD from the Radboud University Nijmegen Diffusion tensor Magnetic resonance-imaging Cohort (RUNDMC) who underwent baseline assessment in 2006 and follow-up in 2011, 2015 and 2020...
December 2024: Blood Pressure
https://read.qxmd.com/read/38469574/retinal-structure-and-vessel-density-changes-in-cerebral-small-vessel-disease
#31
JOURNAL ARTICLE
Dandan Wang, Lina Wang, Jinjin Wang, Yang Du, Kaiyue Wang, Meizi Wang, Liu Yang, Xingquan Zhao
BACKGROUND: Cerebral small vessel disease (CSVD) attaches people's attention in recent years. In this study, we aim to explore retinal structure and vessel density changes in CSVD patients. METHODS: We collected information on retinal metrics assessed by optical coherence tomography (OCT) and OCT angiography and CSVD characters. Logistic and liner regression was used to analyze the relationship between retinal metrics and CSVD. RESULTS: Vessel density of superficial retinal capillary plexus (SRCP), foveal density- 300 length (FD-300), radial peripapillary capillary (RPC) and thickness of retina were significantly lower in CSVD patients, the difference only existed in the thickness of retina after adjusted relevant risk factors (OR (95% CI): 0...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38468656/usefulness-of-combined-bypass-surgery-for-moyamoya-disease-in-infants-under-1-year-of-age-a-technical-case-report
#32
Masashi Kuwabara, Takahito Okazaki, Daizo Ishii, Hiroshi Kondo, Masahiro Hosogai, Takeshi Hara, Yuyo Maeda, Nobutaka Horie
BACKGROUND: Among pediatric cases of moyamoya disease (MMD), cerebral ischemic symptoms often progress and worsen rapidly in infants under one year of age; therefore, it is important to treat them as early as possible. However, direct bypass surgery is often technically difficult for infants due to their small blood vessels. Here, we describe our technique to resolve the technical challenges encountered during superficial temporal artery-to-middle cerebral artery (STA-MCA) bypass surgery in infants aged <1 year with MMD, focusing on specific procedures...
2024: Surgical Neurology International
https://read.qxmd.com/read/38467658/cognitive-profile-in-cerebral-small-vessel-disease-comparison-between-cerebral-amyloid-angiopathy-and-hypertension-related-microangiopathy
#33
JOURNAL ARTICLE
Eleonora Barucci, Emilia Salvadori, Simona Magi, Martina Squitieri, Giulio Maria Fiore, Lorenzo Ramacciotti, Benedetta Formelli, Francesca Pescini, Anna Poggesi
Cerebral amyloid angiopathy (CAA) is recognized as a cause of cognitive impairment, but its cognitive profile needs to be characterized, also respect to hypertension-related microangiopathy (HA). We aimed at comparing difference or similarity of CAA and HA patients' cognitive profiles, and their associated factors. Participants underwent an extensive clinical, neuropsychological, and neuroimaging protocol. HA patients (n = 39) were more frequently males, with history of vascular risk factors than CAA (n = 32)...
March 11, 2024: Scientific Reports
https://read.qxmd.com/read/38466301/microbleeds-in-heterozygous-htra1-related-cerebral-small-vessel-disease
#34
JOURNAL ARTICLE
Yu Guo, Qing Peng, Chen Ling
No abstract text is available yet for this article.
March 11, 2024: JAMA Neurology
https://read.qxmd.com/read/38465605/cardiovascular-management-in-asymptomatic-silent-cerebral-microbleeds-and-suspected-cerebral-amyloid-angiopathy
#35
REVIEW
Andreas Charidimou, Eric E Smith
Cerebral microbleeds (CMBs) detected on blood-sensitive magnetic resonance imaging sequences are usually a sign of an underlying cerebral small vessel disease such as sporadic cerebral amyloid angiopathy or sporadic nonamyloid small vessel pathology (eg, arteriolosclerosis). Much of the enduring interest in CMBs relates to their high prevalence (partly due to the widespread use of magnetic resonance imaging) in the context of stroke, cognitive impairment and in healthy individuals, and the clinical uncertainties created about the safety of antithrombotic medications due to their association with both future hemorrhagic and ischemic stroke...
March 11, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38465597/relationship-of-perivascular-space-markers-with-incident-dementia-in-cerebral-small-vessel-disease
#36
JOURNAL ARTICLE
Hui Hong, Daniel J Tozer, Hugh S Markus
BACKGROUND: Recent studies, using diffusion tensor image analysis along the perivascular space (DTI-ALPS), suggest impaired perivascular space (PVS) function in cerebral small vessel disease, but they were cross-sectional, making inferences on causality difficult. We determined associations between impaired PVS, measured using DTI-ALPS and PVS volume, and cognition and incident dementia. METHODS: In patients with lacunar stroke and confluent white matter hyperintensities, without dementia at baseline, recruited prospectively in a single center, magnetic resonance imaging was performed annually for 3 years, and cognitive assessments, including global, memory, executive function, and processing speed, were performed annually for 5 years...
March 11, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38464316/association-of-long-term-blood-pressure-variability-with-cerebral-amyloid-angiopathy-related-brain-injury-and-cognitive-decline
#37
Lukas Sveikata, Maria Clara Zanon Zotin, Dorothee Schoemaker, Yuan Ma, Valentina Perosa, Anthipa Chokesuwattanaskul, Andreas Charidimou, Marco Duering, Edip M Gurol, Frédéric Assal, Steven M Greenberg, Anand Viswanathan
INTRODUCTION: Long-term systolic blood pressure variability (BPV) has been proposed as a novel risk factor for dementia, but the underlying mechanisms are largely unknown. We aimed to investigate the association between long-term blood pressure variability (BPV), brain injury, and cognitive decline in patients with mild cognitive symptoms and cerebral amyloid angiopathy (CAA), a well-characterized small-vessel disease that causes cognitive decline in older adults. METHODS: Using a prospective memory clinic cohort, we enrolled 102 participants, of whom 52 with probable CAA...
February 27, 2024: medRxiv
https://read.qxmd.com/read/38463439/quantitative-analysis-of-multimodal-mri-markers-and-clinical-risk-factors-for-cerebral-small-vessel-disease-based-on-deep-learning
#38
JOURNAL ARTICLE
Zhiliang Zhang, Zhongxiang Ding, Fenyang Chen, Rui Hua, Jiaojiao Wu, Zhefan Shen, Feng Shi, Xiufang Xu
BACKGROUND: Cerebral small vessel disease lacks specific clinical manifestations, and extraction of valuable features from multimodal images is expected to improve its diagnostic accuracy. In this study, we used deep learning techniques to segment cerebral small vessel disease imaging markers in multimodal magnetic resonance images and analyze them with clinical risk factors. METHODS AND RESULTS: We recruited 211 lacunar stroke patients and 83 control patients. The patients' cerebral small vessel disease markers were automatically segmented using a V-shaped bottleneck network, and the number and volume were calculated after manual correction...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38461505/association-between-small-vessel-disease-and-financial-capacity-a-study-based-on-cognitively-normal-older-adults
#39
JOURNAL ARTICLE
Xiao Luo, Hui Hong, Kaicheng Li, Qingze Zeng, Xiaocao Liu, Luwei Hong, Jixuan Li, Xinyi Zhang, Siyan Zhong, Xiaopei Xu, Yanxing Chen, Minming Zhang, Peiyu Huang
BACKGROUND: Financial capacity is vital for the elderly, who possess a substantial share of global wealth but are vulnerable to financial fraud. OBJECTIVE: We explored the link between small vessel disease (SVD) and financial capacity in cognitively unimpaired (CU) older adults via both cross-sectional and longitudinal analyses. METHODS: 414 CU participants underwent MRI and completed the Financial Capacity Instrument-Short Form (FCI-SF). Subsequent longitudinal FCI-SF data were obtained from 104, 240, and 141 participants at one, two, and four years, respectively...
March 8, 2024: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38456438/high-sensitivity-cardiac-troponin-t-and-cognitive-function-over-12%C3%A2-months-after-stroke-results-of-the-demdas-study
#40
JOURNAL ARTICLE
Regina von Rennenberg, Christian H Nolte, Thomas G Liman, Simon Hellwig, Christoph Riegler, Jan F Scheitz, Marios K Georgakis, Rong Fang, Felix J Bode, Gabor C Petzold, Peter Hermann, Inga Zerr, Michael Goertler, Kathleen Bernkopf, Silke Wunderlich, Martin Dichgans, Matthias Endres
BACKGROUND: Subclinical myocardial injury in form of hs-cTn (high-sensitivity cardiac troponin)  levels has been associated with cognitive impairment and imaging markers of cerebral small vessel disease (SVD) in population-based and cardiovascular cohorts. Whether hs-cTn is associated with domain-specific cognitive decline and SVD burden in patients with stroke remains unknown. METHODS AND RESULTS: We analyzed patients with acute stroke without premorbid dementia from the prospective multicenter DEMDAS (DZNE [German Center for Neurodegenerative Disease]-Mechanisms of Dementia after Stroke) study...
March 8, 2024: Journal of the American Heart Association
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