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Cerebral Small vessel disease

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https://www.readbyqxmd.com/read/28208146/serum-lipid-fractions-and-cerebral-microbleeds-in-a-healthy-japanese-population
#1
Shingo Mitaki, Atsushi Nagai, Hiroaki Oguro, Shuhei Yamaguchi
BACKGROUND: Cerebral microbleeds (CMBs) are associated with focal hemosiderin deposits and represent a form of cerebral small vessel disease. To date, indefinite and inconsistent reports are available regarding the association between serum lipid fractions and CMBs. In addition, these previous studies did not include Asian populations, who may have a higher risk of cerebral hemorrhage. The purpose of this study was to examine the associations between serum lipid fractions and CMBs in healthy Japanese subjects...
February 17, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28202749/endothelial-cell-oligodendrocyte-interactions-in-small-vessel-disease-and-aging
#2
REVIEW
Rikesh M Rajani, Anna Williams
Cerebral small vessel disease (SVD) is a prevalent, neurological disease that significantly increases the risk of stroke and dementia. The main pathological changes are vascular, in the form of lipohyalinosis and arteriosclerosis, and in the white matter (WM), in the form of WM lesions. Despite this, it is unclear to what extent the key cell types involved-the endothelial cells (ECs) of the vasculature and the oligodendrocytes of the WM-interact. Here, we describe the work that has so far been carried out suggesting an interaction between ECs and oligodendrocytes in SVD...
March 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28196940/intravoxel-incoherent-motion-imaging-in-small-vessel-disease-microstructural-integrity-and-microvascular-perfusion-related-to-cognition
#3
C Eleana Zhang, Sau May Wong, Renske Uiterwijk, Julie Staals, Walter H Backes, Erik I Hoff, Tobien Schreuder, Cécile R L P N Jeukens, Jacobus F A Jansen, Robert J van Oostenbrugge
BACKGROUND AND PURPOSE: Cerebral small vessel disease (SVD) is associated with cognitive impairment. This may be because of decreased microstructural integrity and microvascular perfusion, but data on these relationships are scarce. We determined the relationship between cognition and microvascular perfusion and microstructural integrity in SVD patients, using intravoxel incoherent motion imaging-a diffusion-weighted magnetic resonance imaging technique designed to determine microvascular perfusion and microstructural integrity simultaneously...
February 14, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28180080/simultaneous-investigation-of-microvasculature-and-parenchyma-in-cerebral-small-vessel-disease-using-intravoxel-incoherent-motion-imaging
#4
Sau May Wong, C Eleana Zhang, Frank C G van Bussel, Julie Staals, Cécile R L P N Jeukens, Paul A M Hofman, Robert J van Oostenbrugge, Walter H Backes, Jacobus F A Jansen
INTRODUCTION: Cerebral small vessel disease (cSVD) is associated with microvascular and parenchymal alterations. Intravoxel incoherent motion (IVIM) MRI has been proposed to simultaneously measure both the microvascular perfusion and parenchymal diffusivity. This study aimed to evaluate the application of IVIM in cSVD to assess the microvasculature and parenchymal microstructure. METHODS: Seventy-three patients with cSVD (age 70 ± 11 y) and thirty-nine controls (age 69 ± 12 y) underwent IVIM imaging (3T)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28176642/granulocyte-colony-stimulating-factor-attenuates-blood-brain-barrier-damage-and-improves-cognitive-function-in-spontaneously-hypertensive-rats
#5
Xin Wei, Yan Xu, Yanling Jin, Hongliang Feng, Shouquan Dong
Cerebral small vessel diseases (CSVDs) always coincide with endothelial dysfunction and blood-brain barrier (BBB) damage. Granulocyte-colony stimulating factor (G-CSF) can play a neuroprotective role in many neurological diseases. We investigated whether G-CSF exerts positive effects in spontaneously hypertensive rats (SHRs), a rat model of CSVD. Twenty-four-week-old SHRs, displaying the early histopathological changes of CSVD, received daily administrations of either G-CSF (50μg/kg) or saline for 7 days. The novel object recognition test was then conducted after treatment...
February 7, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28169884/mri-progression-of-cerebral-small-vessel-disease-and-cognitive-decline-in-patients-with-hypertension
#6
Renske Uiterwijk, Julie Staals, Marjolein Huijts, Peter W de Leeuw, Abraham A Kroon, Robert J van Oostenbrugge
OBJECTIVE: Hypertension is associated with cognitive deficits, probably because it is a major risk factor for the development of white matter hyperintensities (WMH), lacunes, and cerebral microbleeds, which are MRI markers of cerebral small vessel disease. Studies into associations between presence or progression of these MRI markers and cognitive decline in hypertensive patients are rare. We investigated the association of baseline presence and progression of MRI markers of cerebral small vessel disease with cognitive decline over 4 years in patients with hypertension...
February 6, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28157096/only-white-matter-hyperintensities-predicts-post-stroke-cognitive-performances-among-cerebral-small-vessel-disease-markers-results-from-the-tabasco-study
#7
Jeremy Molad, Efrat Kliper, Amos D Korczyn, Einor Ben Assayag, Dafna Ben Bashat, Shani Shenhar-Tsarfaty, Orna Aizenstein, Ludmila Shopin, Natan M Bornstein, Eitan Auriel
BACKGROUND: White matter hyperintensities (WMH) were shown to predict cognitive decline following stroke or transient ischemic attack (TIA). However, WMH are only one among other radiological markers of cerebral small vessel disease (SVD). OBJECTIVE: The aim of this study was to determine whether adding other SVD markers to WMH improves prediction of post-stroke cognitive performances. METHODS: Consecutive first-ever stroke or TIA patients (n = 266) from the Tel Aviv Acute Brain Stroke Cohort (TABASCO) study were enrolled...
February 1, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28154097/cerebral-vascular-disease-and-neurovascular-injury-in-ischemic-stroke
#8
Xiaoming Hu, T Michael De Silva, Jun Chen, Frank M Faraci
The consequences of cerebrovascular disease are among the leading health issues worldwide. Large and small cerebral vessel disease can trigger stroke and contribute to the vascular component of other forms of neurological dysfunction and degeneration. Both forms of vascular disease are driven by diverse risk factors, with hypertension as the leading contributor. Despite the importance of neurovascular disease and subsequent injury after ischemic events, fundamental knowledge in these areas lag behind our current understanding of neuroprotection and vascular biology in general...
February 3, 2017: Circulation Research
https://www.readbyqxmd.com/read/28152028/serum-phosphorus-levels-and-risk-of-incident-dementia
#9
Tingting Li, Yan Xie, Benjamin Bowe, Hong Xian, Ziyad Al-Aly
Higher serum phosphorous is associated with cerebral small vessel disease, an important driver of cognitive decline and dementia. Whether serum phosphorous, a potentially modifiable parameter, associates with risk of incident dementia is not known. We aimed to examine the association between serum phosphorous and risk of incident dementia and to determine if the association is modified by age. We used the United States Department of Veterans Affairs national databases to build a longitudinal observational cohort of US veterans without prior history of dementia and with at least one outpatient serum phosphorus between October 2008 and September 2010 and followed them until September 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28145796/identification-of-neurovascular-changes-associated-with-cerebral-amyloid-angiopathy-from-subject-specific-hemodynamic-response-functions
#10
Rebecca J Williams, Bradley G Goodyear, Stefano Peca, Cheryl R McCreary, Richard Frayne, Eric E Smith, G Bruce Pike
Cerebral amyloid angiopathy (CAA) is a small-vessel disease preferentially affecting posterior brain regions. Recent evidence has demonstrated the efficacy of functional MRI in detecting CAA-related neurovascular injury, however, it is unknown whether such perturbations are associated with changes in the hemodynamic response function (HRF). Here we estimated HRFs from two different brain regions from block design activation data, in light of recent findings demonstrating how block designs can accurately reflect HRF parameter estimates while maximizing signal detection...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28143956/correlation-between-serum-s100%C3%AE-protein-levels-and-cognitive-dysfunction-in-patients-with-cerebral-small-vessel-disease-a-case-control-study
#11
Fei Wang, Zhi-Rong Zou, Dong Yuan, Yi Gong, Li Zhang, Xun Chen, Tao Sun, Hua-Lin Yu
The present study is designed to explore the correlation between serum S100β level and cognitive dysfunction in patients with cerebral small vessel disease (SVD). A total of 172 SVD patients were participated into the study, and they were assigned into patients with no cognitive impairment (NCI group) and those with vascular cognitive impairment no dementia (VCIND group). Besides, 105 people were recruited as the normal control group. Serum S100β protein level was detected by ELISA. Receiver operating characteristic (ROC) curve was employed the predictive value of serum S100β in diagnosing SVD with cognitive dysfunction...
January 31, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28143923/cerebral-microbleeds-as-predictors-of-mortality-the-framingham-heart-study
#12
José R Romero, Sarah R Preis, Alexa Beiser, Jayandra J Himali, Ashkan Shoamanesh, Philip A Wolf, Carlos S Kase, Vasan S Ramachandran, Charles DeCarli, Sudha Seshadri
BACKGROUND AND PURPOSE: Cerebral microbleeds (CMB) represent a common magnetic resonance imaging marker of cerebral small vessel disease, increasingly recognized as a subclinical marker of stroke and dementia risk. CMB detection may reflect the cumulative effect of vascular risk burden and be a marker of higher mortality. We investigated the relation of CMB to risk of death in community dwelling participants free of stroke and dementia. METHODS: We evaluated 1963 Framingham Original and Offspring Cohort participants (mean age 67 years; 54% women) with available brain magnetic resonance imaging and mortality data...
January 31, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28143595/elevated-blood-viscosity-is-associated-with-cerebral-small-vessel-disease-in-patients-with-acute-ischemic-stroke
#13
Seung Hoon Song, Jeong Hee Kim, Joon Hwa Lee, Yeo-Min Yun, Dong-Hee Choi, Hahn Young Kim
BACKGROUND: Increased level of blood viscosity, which is one of the major factors that determine blood rheology, has been reported as a risk factor or predictor for cerebrovascular events. We investigated how blood viscosity is associated with acute stroke and chronic radiological manifestations of cerebral small vessel disease, and how blood viscosity changes after stroke. METHODS: We prospectively enrolled consecutive patients with acute ischemic stroke. Whole blood viscosities at a low or high shear rate were measured using a scanning capillary tube viscometer, and were referred to as diastolic blood viscosity (DBV) and systolic blood viscosity (SBV), respectively...
January 31, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28137552/small-vessel-disease-is-linked-to-disrupted-structural-network-covariance-in-alzheimer-s-disease
#14
Sean M Nestor, Bratislav Mišić, Joel Ramirez, Jiali Zhao, Simon J Graham, Nicolaas P L G Verhoeff, Donald T Stuss, Mario Masellis, Sandra E Black
INTRODUCTION: Cerebral small vessel disease (SVD) is thought to contribute to Alzheimer's disease (AD) through abnormalities in white matter networks. Gray matter (GM) hub covariance networks share only partial overlap with white matter connectivity, and their relationship with SVD has not been examined in AD. METHODS: We developed a multivariate analytical pipeline to elucidate the cortical GM thickness systems that covary with major network hubs and assessed whether SVD and neurodegenerative pathologic markers were associated with attenuated covariance network integrity in mild AD and normal elderly control subjects...
January 27, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28135646/gap-free-segmentation-of-vascular-networks-with-automatic-image-processing-pipeline
#15
Chih-Yang Hsu, Mahsa Ghaffari, Ali Alaraj, Michael Flannery, Xiaohong Joe Zhou, Andreas Linninger
Current image processing techniques capture large vessels reliably but often fail to preserve connectivity in bifurcations and small vessels. Imaging artifacts and noise can create gaps and discontinuity of intensity that hinders segmentation of vascular trees. However, topological analysis of vascular trees require proper connectivity without gaps, loops or dangling segments. Proper tree connectivity is also important for high quality rendering of surface meshes for scientific visualization or 3D printing...
January 21, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28131162/resting-state-fmri-regional-homogeneity-correlates-with-cognition-measures-in-subcortical-vascular-cognitive-impairment
#16
Stefano Diciotti, Stefano Orsolini, Emilia Salvadori, Antonio Giorgio, Nicola Toschi, Stefano Ciulli, Andrea Ginestroni, Anna Poggesi, Nicola De Stefano, Leonardo Pantoni, Domenico Inzitari, Mario Mascalchi
BACKGROUND: The hyperintensity of cerebral white matter (WM) in T2-weighted MR images of elderly subjects due to small vessel disease (SVD) is associated with variable clinical features including mild cognitive impairment (MCI), also termed subcortical vascular cognitive impairment (SVCI). The latter is typically characterized by psychomotor slowing, attention deficits, and executive dysfunctions. We hypothesized that functional brain changes might be associated with these distinctive cognitive deficits in patients with SVCI...
February 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28130469/small-vessel-disease-burden-in-cerebral-amyloid-angiopathy-without-symptomatic-hemorrhage
#17
Gregoire Boulouis, Andreas Charidimou, Michael J Jessel, Li Xiong, Duangnapa Roongpiboonsopit, Panagiotis Fotiadis, Marco Pasi, Alison Ayres, M Emily Merrill, Kristin M Schwab, Jonathan Rosand, M Edip Gurol, Steven M Greenberg, Anand Viswanathan
OBJECTIVE: Cerebral amyloid angiopathy (CAA) is a common age-related small vessel disease (SVD). Patients without intracerebral hemorrhage (ICH) typically present with transient focal neurologic episodes (TFNEs) or cognitive symptoms. We sought to determine if SVD lesion burden differed between patients with CAA first presenting with TFNEs vs cognitive symptoms. METHODS: A total of 647 patients presenting either to a stroke department (n = 205) or an outpatient memory clinic (n = 442) were screened for eligibility...
January 27, 2017: Neurology
https://www.readbyqxmd.com/read/28128022/different-types-of-white-matter-hyperintensities-in-cadasil-insights-from-7-tesla-mri
#18
François De Guio, Alexandre Vignaud, Hugues Chabriat, Eric Jouvent
In Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), by contrast to sporadic cerebral small vessel disease related to age and hypertension, white matter hyperintensities (WMH) are frequently observed in the white matter of anterior temporal poles, external capsules, and superior frontal regions. Whether these WMH (specific WMH) differ from those observed in other white matter areas (nonspecific WMH) remains unknown. Twenty patients were scanned to compare specific and nonspecific WMH using high-resolution images and analyses of relaxation times (T1R: longitudinal relaxation time and T2*R: effective transversal relaxation time)...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28126975/-cerebral-autosomal-recessive-arteriopathy-with-subcortical-infarcts-and-leukoencephalopathy-carasil
#19
Masahiro Uemura, Hiroaki Nozaki, Osamu Onodera
Cerebral small vessel disease (CSVD) is frequently observed among the elderly and is known to cause dementia and gait disturbance associated with white matter lesions, lacunar infarcts, and cerebral hemorrhage. Molecular mechanistic studies promise to provide new insights into the pathogenesis of hereditary CSVD. Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is one of the hereditary CSVDs caused by a mutation in the high-temperature requirement serine peptidase A1 (HTRA1) gene...
January 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28112032/spermidine-preconditioning-ameliorates-laurate-induced-brain-injury-by-maintaining-mitochondrial-stability
#20
Yi Zhang, Jie Yin, Lang Zhang, Chu-Chu Qi, Ze-Lin Ma, Li-Ping Gao, De-Gui Wang, Yu-Hong Jing
Ischemic precondition plays a protective effect during cerebral ischemia. This effect partly depends on the autophagic activity. However, whether the activity of autophagy can exert the protective effects after cerebral ischemia is unclear. In this study, rats were treated with spermidine, an activator of autophagy, and injected with sodium laurate via the internal carotid artery to stimulate cerebral small vessel disease (CSVD). The effects of the spermidine precondition on brain injury were evaluated by behavioural test, histology assay, ultrastructure observation, and autophagic-related signals...
March 2017: Neurological Research
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