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Cerebral amyloid angiopathy

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https://www.readbyqxmd.com/read/28941799/regulatory-effects-of-simvastatin-and-apoj-on-app-processing-and-amyloid-%C3%AE-clearance-in-blood-brain-barrier-endothelial-cells
#1
Martina Zandl-Lang, Elham Fanaee-Danesh, Yidan Sun, Igor Čančar, Chaitanya Chakravarthi Gali, Alexandra Kober, Nicole M Albrecher, Carmen Tam-Amersdorfer, Anika Stracke, Steffen Storck, Ahmed Saeed, Jasminka Stefulj, Claus Pietrzik, Mark R Wilson, Ingemar Björkhem, Ute Panzenboeck
Amyloid-β peptides (Aβ) accumulate in cerebral capillaries indicating a central role of the blood-brain barrier (BBB) in the pathogenesis of Alzheimer's disease (AD). Although a relationship between apolipoprotein-, cholesterol- and Aβ metabolism is evident, the interconnecting mechanisms operating in brain capillary endothelial cells (BCEC) are poorly understood. ApoJ (clusterin) is present in HDL that regulates cholesterol metabolism which is disturbed in AD. ApoJ levels are increased in AD brains and in plasma of cerebral amyloid angiopathy (CAA) patients...
September 20, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28939709/topography-and-determinants-of-magnetic-resonance-imaging-mri-visible-perivascular-spaces-in-a-large-memory-clinic-cohort
#2
Sara Shams, Juha Martola, Andreas Charidimou, Mykol Larvie, Tobias Granberg, Mana Shams, Maria Kristoffersen-Wiberg, Lars-Olof Wahlund
BACKGROUND: Magnetic resonance imaging-visible perivascular spaces (PVS) are related to interstitial fluid clearance pathways (including amyloid-β) in the brain and are suggested to be a marker of cerebral small vessel disease. We investigated the role, topography, and possible implications of PVS in cognitive impairment. METHODS AND RESULTS: A total of 1504 patients undergoing memory clinic investigation and an associated brain magnetic resonance imaging scan were included in this cross-sectional study...
September 22, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28931619/spinal-arteriolosclerosis-is-common-in-older-adults-and-associated-with-parkinsonism
#3
Aron S Buchman, Sue E Leurgans, Sukriti Nag, Veronique G J M VanderHorst, Alifiya Kapasi, Julie A Schneider, David A Bennett
BACKGROUND AND PURPOSE: There are few studies of spinal microvascular pathologies in older adults. We characterized spinal cord microvascular pathologies and examined their associations with other spinal and brain postmortem indices and parkinsonism in older adults. METHODS: We documented 3 features of microvascular pathologies in spinal cord and brain specimens from 165 deceased older participants. We also measured spinal white matter pallor. Parkinsonian signs were assessed with a modified version of the motor section of the Unified Parkinson's Disease Rating Scale...
September 20, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28888720/aged-chimpanzees-exhibit-pathologic-hallmarks-of-alzheimer-s-disease
#4
Melissa K Edler, Chet C Sherwood, Richard S Meindl, William D Hopkins, John J Ely, Joseph M Erwin, Elliott J Mufson, Patrick R Hof, Mary Ann Raghanti
Alzheimer's disease (AD) is a uniquely human brain disorder characterized by the accumulation of amyloid-beta protein (Aβ) into extracellular plaques, neurofibrillary tangles (NFT) made from intracellular, abnormally phosphorylated tau, and selective neuronal loss. We analyzed a large group of aged chimpanzees (n = 20, age 37-62 years) for evidence of Aβ and tau lesions in brain regions affected by AD in humans. Aβ was observed in plaques and blood vessels, and tau lesions were found in the form of pretangles, NFT, and tau-immunoreactive neuritic clusters...
November 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28879426/cerebral-amyloid-angiopathy-subtypes-treatment-and-role-in-cognitive-impairment
#5
D McLauchlan, G A Malik, N P Robertson
No abstract text is available yet for this article.
September 6, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28870591/hemorrhage-recurrence-risk-factors-in-cerebral-amyloid-angiopathy-comparative-analysis-of-the-overall-small-vessel-disease-severity-score-versus-individual-neuroimaging-markers
#6
Gregoire Boulouis, Andreas Charidimou, Marco Pasi, Duangnapa Roongpiboonsopit, Li Xiong, Eitan Auriel, Ellis S van Etten, Sergi Martinez-Ramirez, Alison Ayres, Anastasia Vashkevich, Kristin M Schwab, Jonathan Rosand, Joshua N Goldstein, M Edip Gurol, Steven M Greenberg, Anand Viswanathan
INTRODUCTION: An MRI-based score of total small vessel disease burden (CAA-SVD-Score) in cerebral amyloid angiopathy (CAA) has been demonstrated to correlate with severity of pathologic changes. Evidence suggests that CAA-related intracerebral hemorrhage (ICH) recurrence risk is associated with specific disease imaging manifestations rather than overall severity. We compared the correlation between the CAA-SVD-Score with the risk of recurrent CAA-related lobar ICH versus the predictive role of each of its components...
September 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28870521/clinical-aspects-and-biomarkers-of-alzheimer-s-disease-in-down-syndrome
#7
REVIEW
Panagiotis Zis, Andre Strydom
Alzheimer's disease (AD) may affect in excess of 90% of individuals with Down syndrome (DS) after age 60, due to duplication of the APP gene in trisomy of chromosome 21, with neuropathology that is comparable to Sporadic AD and Familial AD (FAD). Previous literature suggested some unique features in clinical presentation of dementia in DS (DSd), which might be due to diagnostic difficulties, or represent a real difference compared to SAD or FAD. We review current knowledge on clinical diagnosis and presentation of dementia in DS in comparison with FAD due to APP mutations and APP duplication...
September 1, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28864038/radiologically-isolated-cerebral-amyloid-angiopathy-related-inflammation
#8
Dimitri Renard, Anne Wacongne, Eric Thouvenot
In amyloid β-related angiitis of the central nervous system (also called cerebral amyloid angiopathy-related inflammation), cerebral amyloid angiopathy occurs in association with primary vasculitis of small- and medium-sized leptomeningeal and cortical arteries. To avoid brain biopsy, clinicoradiological criteria (including clinical features due to inflammation-related uni/multifocal white matter hyperintensities) for the diagnosis of cerebral amyloid angiopathy-related inflammation have been validated recently...
August 29, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28855406/amyloid-pet-in-sporadic-cerebral-amyloid-angiopathy-a-diagnostic-accuracy-meta-analysis
#9
Andreas Charidimou, Karim Farid, Jean-Claude Baron
OBJECTIVE: To perform a meta-analysis synthesizing evidence of the value and accuracy of amyloid-PET in diagnosing patients with sporadic cerebral amyloid angiopathy (CAA). METHODS: In a PubMed systematic literature search, we identified all case-control studies with extractable data relevant for the sensitivity and specificity of amyloid-PET positivity in symptomatic patients with CAA (cases) vs healthy participants or patients with spontaneous deep intracerebral hemorrhage (ICH) (control groups)...
August 30, 2017: Neurology
https://www.readbyqxmd.com/read/28855405/amyloid-pet-in-cerebral-amyloid-angiopathy-detecting-vascular-amyloid-deposits-not-just-blood
#10
EDITORIAL
Nicolas Raposo, Joshua A Sonnen
No abstract text is available yet for this article.
August 30, 2017: Neurology
https://www.readbyqxmd.com/read/28844070/the-increasing-impact-of-cerebral-amyloid-angiopathy-essential-new-insights-for-clinical-practice
#11
REVIEW
Gargi Banerjee, Roxana Carare, Charlotte Cordonnier, Steven M Greenberg, Julie A Schneider, Eric E Smith, Mark van Buchem, Jeroen van der Grond, Marcel M Verbeek, David J Werring
Cerebral amyloid angiopathy (CAA) has never been more relevant. The last 5 years have seen a rapid increase in publications and research in the field, with the development of new biomarkers for the disease, thanks to advances in MRI, amyloid positron emission tomography and cerebrospinal fluid biomarker analysis. The inadvertent development of CAA-like pathology in patients treated with amyloid-beta immunotherapy for Alzheimer's disease has highlighted the importance of establishing how and why CAA develops; without this information, the use of these treatments may be unnecessarily restricted...
August 26, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28841840/can-brain-impermeable-bace1-inhibitors-serve-as-anti-caa-medicine
#12
Jian-Ming Li, Li-Ling Huang, Fei Liu, Bei-Sha Tang, Xiao-Xin Yan
BACKGROUND: Cerebral amyloid angiopathy (CAA) is characterized by the deposition of ß-amyloid peptides (Aß) in and surrounding the wall of microvasculature in the central nervous system, together with parenchymal amyloid plaques collectively referred to as cerebral amyloidosis, which occurs in the brain commonly among the elderly and more frequently in patients with Alzheimer's disease (AD). CAA is associated with vascular injury and may cause devastating neurological outcomes. No therapeutic approach is available for this lesion to date...
August 25, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28838368/cerebral-amyloid-angiopathy-diagnosis-clinical-implications-and-management-strategies-in-atrial-fibrillation
#13
REVIEW
Christopher V DeSimone, Jonathan Graff-Radford, Majd A El-Harasis, Alejandro A Rabinstein, Samuel J Asirvatham, David R Holmes
With an aging population, clinicians are more frequently encountering patients with atrial fibrillation who are also at risk of intracerebral hemorrhage due to cerebral amyloid angiopathy, the result of β-amyloid deposition in cerebral vessels. Cerebral amyloid angiopathy is common among elderly patients, and is associated with an increased risk of intracerebral bleeding, especially with the use of anticoagulation. Despite this association, this entity is absent in current risk-benefit analysis models, which may result in underestimation of the chance of bleeding in the subset of patients with this disease...
August 29, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28836300/cerebral-amyloid-angiopathy-initially-occurs-in-the-meningeal-vessels
#14
Shigeki Takeda, Kazunori Yamazaki, Teruo Miyakawa, Kiyoshi Onda
To clarify the frequency of CAA in the brain parenchyma and subarachnoid space (SAS), we counted sections of blood vessels showing positive staining for Aβ in the SAS, cerebral cortex (CC) and cerebral white matter (WM) using paraffin-embedded sections of the frontal, temporal and occipital lobes. The specimens had been taken for routine neuropathological examination from the brains of 105 Japanese patients (aged 40-95 years) selected from among 200 consecutive patients autopsied between 1989 and 2015 at our hospital...
August 23, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28834018/gba-mutations-in-parkinson-disease-earlier-death-but-similar-neuropathological-features
#15
C H Adler, T G Beach, H A Shill, J N Caviness, E Driver-Dunckley, M N Sabbagh, A Patel, L I Sue, G Serrano, S A Jacobson, K Davis, C M Belden, B N Dugger, S A Paciga, A R Winslow, W D Hirst, J G Hentz
BACKGROUND AND PURPOSE: Mutations in the glucocerebrosidase (GBA) gene are known to be a risk factor for Parkinson's disease (PD). Data on clinicopathological correlation are limited. The purpose of this study was to determine the clinicopathological findings that might distinguish PD cases with and without mutations in the GBA gene. METHODS: Data from the Arizona Study of Aging and Neurodegenerative Disorders were used to identify autopsied PD cases that did or did not have a GBA gene mutation...
August 17, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28833176/cerebral-amyloid-angiopathy-as-a-cause-of-neurodegeneration
#16
REVIEW
Eric E Smith
Sporadic, age-related cerebral amyloid angiopathy (CAA) is most commonly recognized clinically as a cause of hemorrhagic stroke and transient focal neurological episodes in older persons. But a growing body of research in the last five years shows that the pathophysiology of CAA is much more complex than previously believed, leading to many different types of brain injury. CAA has now been linked with brain atrophy in regions remote from those directly affected by intracerebral hematomas, and with risk for progressive cognitive decline in the absence of new hemorrhagic strokes...
August 21, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28826581/uncommon-causes-of-cerebral-microbleeds
#17
REVIEW
Nariman Noorbakhsh-Sabet, Varun Chandi Pulakanti, Ramin Zand
BACKGROUND: Cerebral microbleeds (CMBs) are small and round perivascular hemosiderin depositions detectable by gradient echo sequences or susceptibility-weighted imaging. Cerebral microbleeds are common among patients with hypertension, cerebral ischemia, or cerebral amyloid angiopathy. In this article, we describe uncommon causes of CMBs. METHODS: We searched Pubmed with the keyword CMBs for relevant studies and looked for different uncommon causes of CMBs. RESULTS: CMBs have several uncommon etiologies including posterior reversible encephalopathy syndrome, infective endocarditis, brain radiation therapy, cocaine abuse, thrombotic thrombocytopenic purpura, traumatic brain injury, intravascular lymphomatosis or proliferating angio-endotheliomatosis, moyamoya disease, sickle cell anemia/β-thalassemia, cerebral autosomal dominant arteriopathy subcortical infarcts, and leukoencephalopathy (CADASIL), genetic syndromes, or obstructive sleep apnea...
August 17, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28801214/lobar-hemorrhage-induced-by-acquired-factor-xiii-deficiency-in-a-patient-with-cerebral-amyloid-angiopathy
#18
Hidetaka Arishima, Hiroyuki Neishi, Ken-Ichiro Kikuta, Mihoko Morita, Naoko Hosono, Takahiro Yamauchi, Masayoshi Souri, Akitada Ichinose
A 68-year-old man presented with intracranial hemorrhage in the right frontal lobe, which rapidly increased the day after admission. We performed hematoma removal with a biopsy of the cortex around the hematoma. The day after the operation, a subcutaneous hematoma over the craniotomy appeared, and the computed tomography showed a recurrent hemorrhage with an acute subdural hematoma. We were aware of a bleeding tendency, and a detailed hematologic examination by hematologists revealed autoimmune acquired factor XIII deficiency due to an antifactor XIII antibody...
August 8, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28761931/unc5c-variants-are-associated-with-cerebral-amyloid-angiopathy
#19
Hyun-Sik Yang, Charles C White, Lori B Chibnik, Hans-Ulrich Klein, Julie A Schneider, David A Bennett, Philip L De Jager
OBJECTIVE: To determine whether common genetic variants in UNC5C, a recently identified late-onset Alzheimer disease (LOAD) dementia susceptibility gene, are associated with AD susceptibility or AD-related clinical/pathologic phenotypes. METHODS: We used data from deceased individuals of European descent who participated in the Religious Orders Study or the Rush Memory and Aging Project (n = 1,288). We examined whether there were associations between single nucleotide polymorphisms (SNPs) within ±100 kb of the UNC5C gene and a diagnosis of AD dementia, global cognitive decline, a pathologic diagnosis of AD, β-amyloid load, neuritic plaque count, diffuse plaque count, paired helical filament tau density, neurofibrillary tangle count, and cerebral amyloid angiopathy (CAA) score...
August 2017: Neurology. Genetics
https://www.readbyqxmd.com/read/28760945/inactivation-of-nitric-oxide-synthesis-exacerbates-the-development-of-alzheimer-disease-pathology-in-appps1-mice-amyloid-precursor-protein-presenilin-1
#20
Diana Cifuentes, Marine Poittevin, Philippe Bonnin, Anta Ngkelo, Nathalie Kubis, Tatyana Merkulova-Rainon, Bernard I Lévy
The epidemiological link between hypertension and Alzheimer disease is established. We previously reported that hypertension aggravates the Alzheimer-like pathology in APPPS1 mice (amyloid precursor protein/presenilin-1, mouse model of Alzheimer disease) with angiotensin II-induced hypertension, in relation with hypertension and nitric oxide deficiency. To provide further insights into the role of nitric oxide in the hypertension-Alzheimer disease cross-talk, we studied the effects of nitric oxide blockade in APPPS1 mice using N(ω)-nitro-l-arginine methyl ester (l-NAME) alone or in combination with hydralazine, to normalize blood pressure...
July 31, 2017: Hypertension
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