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Cerebral amyloid angiopathy

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https://www.readbyqxmd.com/read/29786594/-brain-microbleeds-definition-pathophysiology-and-the-consequences
#1
Marek Mazurek, Ewa Papuć, Konrad Rejdak
Brain microbleeds are defined as small, circular hypointense changes in T2-sequensec of brain MRI, well demarcated from the surrounding tissue. They represent the phagocytized products of blood distribution extravasated from pathologically altered vessels. The echo-T2-dependent gradient (GRE) and magnetic susceptibility testing (SWI) sequences are usually used to visualize them. The pathogenesis of microbleeds very complex but angiopathy associated with arterial hypertension and cerebral amyloid angiopathy play a special role...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29780860/microbleeds-are-associated-with-depressive-symptoms-in-alzheimer-s-disease
#2
Anna E Leeuwis, Niels D Prins, Astrid M Hooghiemstra, Marije R Benedictus, Philip Scheltens, Frederik Barkhof, Wiesje M van der Flier
Introduction: Co-occurrence of cerebrovascular disease and depression led to the "vascular depression hypothesis". White matter hyperintensities (WMHs) have been associated with depressive symptoms in population-based studies. We studied the association between small vessel disease and depressive symptoms in a memory clinic population. Methods: We included >2000 patients with subjective cognitive decline (SCD), mild cognitive impairment, and Alzheimer's disease (AD)...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29770843/patterns-and-severity-of-vascular-amyloid-in-alzheimer-s-disease-associated-with-duplications-and-missense-mutations-in-app-gene-down-syndrome-and-sporadic-alzheimer-s-disease
#3
David M A Mann, Yvonne S Davidson, Andrew C Robinson, Nancy Allen, Tadafumi Hashimoto, Anna Richardson, Matthew Jones, Julie S Snowden, Neil Pendleton, Marie-Claude Potier, Annie Laquerrière, Vee Prasher, Takeshi Iwatsubo, Andre Strydom
In this study, we have compared the severity of amyloid plaque formation and cerebral amyloid angiopathy (CAA), and the subtype pattern of CAA pathology itself, between APP genetic causes of AD (APPdup, APP mutations), older individuals with Down syndrome (DS) showing the pathology of Alzheimer's disease (AD) and individuals with sporadic (early and late onset) AD (sEOAD and sLOAD, respectively). The aim of this was to elucidate important group differences and to provide mechanistic insights related to clinical and neuropathological phenotypes...
May 16, 2018: Acta Neuropathologica
https://www.readbyqxmd.com/read/29760289/-neurocognitive-disorders-other-than-alzheimer-disease-vascular-dementia
#4
Mari Yoshida
Vascular dementia involves several mechanism of pathogenesis. Cerebral small vessel diseases play a central role in vascular dementia, including sporadic cerebral small vessel diseases, cerebral autosomal-dominant or autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL or CARASIL), cerebral amyloid angiopathy, and amyloid β-related angiitis. Although these diseases have different pathomechanisms, chronic white matter hypoperfusion contributes to development of neuronal dysfunction as a common pathway in vascular dementia...
May 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29754590/cerebral-amyloid-angiopathy-mimicking-central-nervous-system-metastases-a-case-report
#5
Christopher DeZorzi, Ruth Fernandez-Ruiz, Sarika Gupta, Katherine Harris
BACKGROUND: This case describes an unusual presentation of an intracranial hemorrhage first thought to be metastatic disease on computed tomography and magnetic resonance imaging. The healthcare team completed an exhaustive search for a primary malignancy that was negative. Final diagnosis on brain biopsy showed intercranial hemorrhage secondary to cerebral amyloid angiopathy. With an increasing number of elderly patients and the rising cost of health care, this case can serve as a reminder to clinicians about their own responsibilities in limiting the cost of health care...
May 14, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29754206/convective-influx-glymphatic-system-tracers-injected-into-the-csf-enter-and-leave-the-brain-along-separate-periarterial-basement-membrane-pathways
#6
Nazira J Albargothy, David A Johnston, Matthew MacGregor-Sharp, Roy O Weller, Ajay Verma, Cheryl A Hawkes, Roxana O Carare
Tracers injected into CSF pass into the brain alongside arteries and out again. This has been recently termed the "glymphatic system" that proposes tracers enter the brain along periarterial "spaces" and leave the brain along the walls of veins. The object of the present study is to test the hypothesis that: (1) tracers from the CSF enter the cerebral cortex along pial-glial basement membranes as there are no perivascular "spaces" around cortical arteries, (2) tracers leave the brain along smooth muscle cell basement membranes that form the Intramural Peri-Arterial Drainage (IPAD) pathways for the elimination of interstitial fluid and solutes from the brain...
May 12, 2018: Acta Neuropathologica
https://www.readbyqxmd.com/read/29742105/white-matter-hyperintensities-and-the-mediating-role-of-cerebral-amyloid-angiopathy-in-dominantly-inherited-alzheimer-s-disease
#7
Seonjoo Lee, Molly E Zimmerman, Atul Narkhede, Sara E Nasrabady, Giuseppe Tosto, Irene B Meier, Tammie L S Benzinger, Daniel S Marcus, Anne M Fagan, Nick C Fox, Nigel J Cairns, David M Holtzman, Virginia Buckles, Bernardino Ghetti, Eric McDade, Ralph N Martins, Andrew J Saykin, Colin L Masters, John M Ringman, Stefan Fӧrster, Peter R Schofield, Reisa A Sperling, Keith A Johnson, Jasmeer P Chhatwal, Stephen Salloway, Stephen Correia, Clifford R Jack, Michael Weiner, Randall J Bateman, John C Morris, Richard Mayeux, Adam M Brickman
INTRODUCTION: White matter hyperintensity (WMH) volume on MRI is increased among presymptomatic individuals with autosomal dominant mutations for Alzheimer's disease (AD). One potential explanation is that WMH, conventionally considered a marker of cerebrovascular disease, are a reflection of cerebral amyloid angiopathy (CAA) and that increased WMH in this population is a manifestation of this vascular form of primary AD pathology. We examined whether the presence of cerebral microbleeds, a marker of CAA, mediates the relationship between WMH and estimated symptom onset in individuals with and without autosomal dominant mutations for AD...
2018: PloS One
https://www.readbyqxmd.com/read/29710713/rapidly-progressive-alzheimer-s-disease-contributions-to-clinical-pathological-definition-and-diagnosis
#8
Samir Abu-Rumeileh, Sabina Capellari, Piero Parchi
Rapidly progressive Alzheimer's disease (rpAD) has recently been recognized as a clinical disease subtype characterized by rapidly progressive cognitive decline and/or short disease duration, and the possible occurrence of early focal neurological signs. Consistently, rpAD represents a relatively frequent alternative diagnosis among cases referred as possible or probable Creutzfeldt-Jakob disease (CJD) to surveillance centers for prion disease worldwide. Indeed, the early clinical differential diagnosis between the two disorders can be challenging given the partial overlap in clinical features and cerebrospinal fluid (CSF) levels of the protein surrogate markers 14-3-3 and total-tau...
April 25, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29706885/brain-transcriptomic-analysis-of-hereditary-cerebral-hemorrhage-with-amyloidosis-dutch-type
#9
Laure Grand Moursel, Willeke M C van Roon-Mom, Szymon M Kiełbasa, Hailiang Mei, Henk P J Buermans, Linda M van der Graaf, Kristina M Hettne, Emile J de Meijer, Sjoerd G van Duinen, Jeroen F J Laros, Mark A van Buchem, Peter A C 't Hoen, Silvère M van der Maarel, Louise van der Weerd
Hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) is an early onset hereditary form of cerebral amyloid angiopathy (CAA) caused by a point mutation resulting in an amino acid change (NP_000475.1:p.Glu693Gln) in the amyloid precursor protein (APP). Post-mortem frontal and occipital cortical brain tissue from nine patients and nine age-related controls was used for RNA sequencing to identify biological pathways affected in HCHWA-D. Although previous studies indicated that pathology is more severe in the occipital lobe in HCHWA-D compared to the frontal lobe, the current study showed similar changes in gene expression in frontal and occipital cortex and the two brain regions were pooled for further analysis...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29695600/brain-pathology-is-related-to-total-daily-physical-activity-in-older-adults
#10
Aron S Buchman, Robert J Dawe, Lei Yu, Andrew Lim, Robert S Wilson, Julie A Schneider, David A Bennett
OBJECTIVE: To test the hypothesis that brain pathology is associated with total daily physical activity proximate to death in older adults. METHODS: We studied brain autopsies from 428 decedents of the Rush Memory and Aging Project. The quantity of all physical activity was measured continuously for up to 10 days with actigraphy (Actical; Philips Healthcare, Bend, OR). Multiple regression analyses controlling for age and sex were used to examine the relation of brain indexes to total daily physical activity and other clinical covariates proximate to death...
April 25, 2018: Neurology
https://www.readbyqxmd.com/read/29695466/innovative-magnetic-resonance-imaging-markers-of-hereditary-cerebral-amyloid-angiopathy-at-7-tesla
#11
Emma A Koemans, Ellis S van Etten, Anna M van Opstal, Gerda Labadie, Gisela M Terwindt, Marieke J H Wermer, Andrew G Webb, Edip M Gurol, Steven M Greenberg, Mark A van Buchem, Jeroen van der Grond, Sanneke van Rooden
BACKGROUND AND PURPOSE: The aim of the present study is to explore whether using 7 Tesla magnetic resonance imaging, additional brain changes can be observed in hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) patients as compared with the established magnetic resonance imaging features of sporadic cerebral amyloid angiopathy. METHODS: The local institutional review board approved this prospective cohort study. In all cases, informed consent was obtained...
April 25, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29695464/distribution-of-lacunar-infarcts-in-asians-with-intracerebral-hemorrhage-a-magnetic-resonance-imaging-and-amyloid-positron-emission-tomography-study
#12
Hsin-Hsi Tsai, Marco Pasi, Li-Kai Tsai, Ya-Fang Chen, Bo-Ching Lee, Sung-Chun Tang, Panagiotis Fotiadis, Chen-Yu Huang, Ruoh-Fang Yen, M Edip Gurol, Jiann-Shing Jeng
BACKGROUND AND PURPOSE: We evaluated whether lacunes in centrum semiovale (lobar lacunes) were associated with cerebral amyloid angiopathy (CAA) markers in an Asian intracerebral hemorrhage (ICH) population. METHODS: One hundred ten patients with primary ICH were classified as CAA-ICH (n=24; mean age, 70.9±13.9) or hypertensive ICH (n=86; mean age, 59.3±13.0) according to the presence of strictly lobar (per modified Boston criteria) or strictly deep bleeds (both ICH and cerebral microbleeds), respectively...
April 25, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29679649/protein-solvent-interfaces-in-human-y145stop-prion-protein-amyloid-fibrils-probed-by-paramagnetic-solid-state-nmr-spectroscopy
#13
Darryl Aucoin, Yongjie Xia, Theint Theint, Philippe S Nadaud, Krystyna Surewicz, Witold K Surewicz, Christopher P Jaroniec
The C-terminally truncated Y145Stop variant of prion protein (PrP23-144), which is associated with heritable PrP cerebral amyloid angiopathy in humans and also capable of triggering a transmissible prion disease in mice, serves as a useful in vitro model for investigating the molecular and structural basis of amyloid strains and cross-seeding specificities. Here, we determine the protein-solvent interfaces in human PrP23-144 amyloid fibrils generated from recombinant 13 C,15 N-enriched protein and incubated in aqueous solution containing paramagnetic Cu(II)-EDTA, by measuring residue-specific 15 N longitudinal paramagnetic relaxation enhancements using two-dimensional magic-angle spinning solid-state NMR spectroscopy...
April 18, 2018: Journal of Structural Biology
https://www.readbyqxmd.com/read/29678935/atrophy-patterns-in-cerebral-amyloid-angiopathy-with-and-without-cortical-superficial-siderosis
#14
Joonho Kim, Han Kyu Na, Jeong-Hyeon Shin, Hee Jin Kim, Sang Won Seo, Joon-Kyung Seong, Duk L Na
OBJECTIVE: To investigate differential atrophy patterns based on the presence of cortical superficial siderosis (cSS) and the role of cSS in predicting amyloid positivity in memory clinic patients fulfilling the diagnostic criteria for probable cerebral amyloid angiopathy (CAA). METHODS: We retrospectively collected data from 44 cognitively impaired patients with probable CAA who underwent 3-dimensional, T1-weighted MRIs (cSS+, n = 27; cSS-, n = 17). Amyloid-positive patients with Alzheimer disease (AD) (n = 56) and amyloid-negative cognitively normal participants (n = 34) were recruited as controls...
April 20, 2018: Neurology
https://www.readbyqxmd.com/read/29620941/cerebrovascular-%C3%AE-amyloid-deposition-and-associated-microhemorrhages-in-a-tg2576-alzheimer-mouse-model-are-reduced-with-a-dha-enriched-diet
#15
Justine Hur, Véronique Mateo, Nicolas Amalric, Mégane Babiak, Gilbert Béréziat, Claire Kanony-Truc, Thierry Clerc, Régis Blaise, Isabelle Limon
Cerebral amyloid angiopathy (CAA) is a major contributor to Alzheimer's disease (AD) pathogenesis. Like AD, CAA is often accompanied by marked inflammation, aggravating associated vasculopathies. No evidence-based prevention or treatment strategies are available. Here, we evaluate the possible beneficial effect of a diet enriched with docosahexaenoic acid (DHA), which is known to attenuate inflammation in CAA. Tg2576 mice, a transgenic model of AD/CAA, were fed a DHA-enriched diet starting at 2 mo of age and ending at 10, 14, or 18 mo of age...
April 5, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29620074/focal-cerebral-%C3%AE-amyloid-angiopathy-a-distinct-clinicopathologic-presentation
#16
Elissaios Karageorgiou, Georges Naasan, Samuel J Pleasure, Sanda Alexandrescu, Jeffrey M Gelfand, Gautam Tammewar, Bruce L Miller, Gil D Rabinovici, Lea T Grinberg
No abstract text is available yet for this article.
October 2017: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/29614657/cerebral-amyloid-angiopathy-similarity-in-african-americans-and-caucasians-with-alzheimer-s-disease
#17
Dennis M Kamara, Umesh Gangishetti, Marla Gearing, Monica Willis-Parker, Liping Zhao, William T Hu, Lary C Walker
Cerebral amyloid angiopathy (CAA) of the Aβ type is variably present in the brains of patients with Alzheimer's disease (AD). CAA contributes to cognitive decline and increases the risk of lobar hemorrhage; because both AD-typical dementia and lobar hemorrhage are more common in African-Americans than in Caucasians, we postulated that African-Americans with AD might be particularly susceptible to CAA. To test this hypothesis, we analyzed CAA histopathologically in the large vessels and capillaries of autopsy-derived frontal, temporal, parietal, and occipital cortical samples from African-Americans (n = 18) and Caucasians (n = 19) with end-stage AD...
March 24, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29607919/-rapidly-deteriorated-lobar-intracerebral-hemorrhages-possible-association-of-varicella-zoster-virus-vasculopathy
#18
Jun Takeshita, Eiichi Nomura, Makoto Takemaru, Takahiro Himeno, Yutaka Shimoe, Masaru Kuriyama
A 75-year-old man having dementia and lifestyle related diseases developed a lobar intracerebral hemorrhage (LICH) in the left parietal and a small cerebellar infarction in the left occipital lobe. Many micro bleeds (MB) due to cerebral amyloid angiopathy (CAA) in the subcortical areas and multiple vascular stenosis were also found by MRI and MRA. He developed herpes zoster in his buttocks on day 6 of hospitalization and complicated with varicella zoster virus (VZV) meningitis with positive for VZV-DNA in the cerebrospinal fluid...
March 31, 2018: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29604173/cerebral-amyloid-angiopathy-review-of-clinico-radiological-features-and-mimics
#19
REVIEW
Rohit Sharma, Stephanie Dearaugo, Bernard Infeld, Richard O'Sullivan, Richard P Gerraty
Cerebral amyloid angiopathy (CAA) is an important cause of lobar intracerebral haemorrhage (ICH) in the elderly, but has other clinico-radiological manifestations. In the last two decades, certain magnetic resonance imaging (MRI) sequences, namely gradient-recalled echo imaging and the newer and more sensitive susceptibility-weighted imaging, have been utilised to detect susceptibility-sensitive lesions such as cerebral microbleeds and cortical superficial siderosis. These can be utilised sensitively and specifically by the Modified Boston Criteria to make a diagnosis of CAA without the need for 'gold-standard' histopathology from biopsy...
March 31, 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29598904/lipopolysaccharide-induces-subacute-cerebral-microhemorrhages-with-involvement-of-nitric-oxide-synthase-in-rats
#20
Jing Zeng, Hóngyi Zhào, Zhixin Liu, Weiwei Zhang, Yonghua Huang
BACKGROUND: Cerebral microhemorrhage (CMH) is a neuropathological term that could be easily found in cerebral amyloid angiopathy, intracerebral hemorrhages, etc. CMHs could be detected clearly in vivo by magnetic resonance imaging (MRI)-susceptibility-weighted imaging or MRI T2* scan. This terminology is now accepted in the area of neuroimaging. CMHs are quite common in elderly patients and are associated with several other neuropsychiatric disorders. The causes of CMHs are complicated, and neuroinflammation is considered as one of the well-accepted mechanical factors...
March 26, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
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