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Superficial siderosis

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https://www.readbyqxmd.com/read/28089561/characterizing-deep-white-matter-hyperintensities-in-patients-with-symptomatic-isolated-cortical-superficial-siderosis
#1
Dimitri Renard, Lavinia Tatu, Christophe Demattei, Christophe Hirtz, Sylvain Lehmann, Eric Thouvenot
BACKGROUND: In patient with cerebral amyloid angiopathy (CAA) presenting with lobar hemorrhage (LH), magnetic resonance imaging (MRI) white matter hyperintensities (WMH) tend to be predominant in posterior regions with the "multiple subcortical spots" WMH pattern as the most frequent topographical WMH pattern. Our aim was to analyze WMH severity and topographical distribution in patients with cortical superficial siderosis (CSS). METHODS: We retrospectively analyzed MRIs from consecutive symptomatic isolated (i...
January 12, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28019651/infratentorial-superficial-siderosis-classification-diagnostic-criteria-and-rational-investigation-pathway
#2
Duncan Wilson, Fiona Chatterjee, Simon F Farmer, Peter Rudge, Mark O McCarron, Peter Cowley, David J Werring
Central nervous system infratentorial superficial siderosis (iSS) is increasingly detected by blood-sensitive MRI sequences. Despite this, there are no standardized diagnostic criteria, and the clinical-radiological spectrum, causes and optimum investigation strategy are not established. We reviewed clinical and radiological details of patients with iSS assessed at a specialist neurological center from 2004-2016 using pre-defined standardized radiological criteria. All imaging findings were rated blinded to clinical details...
December 26, 2016: Annals of Neurology
https://www.readbyqxmd.com/read/28017208/subjective-hearing-impairment-after-subarachnoid-haemorrhage-prevalence-and-risk-factors
#3
Erik M Vos, Paut Greebe, J M Anne Visser-Meily, Gabriel J E Rinkel, Mervyn D I Vergouwen
BACKGROUND: Sensorineural hearing impairment is a key symptom in patients with superficial siderosis of the central nervous system, a disease caused by chronic or intermittent haemorrhage into the subarachnoid space. We investigated the prevalence and risk factors of subjective hearing impairment after SAH. METHODS: We systematically interviewed all SAH patients admitted between June 2011 and December 2014, who were able to visit the SAH outpatient clinic six to eight weeks after hospital discharge...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27903811/%C3%AE-amyloid-in-csf-biomarker-for-preclinical-cerebral-amyloid-angiopathy
#4
Ellis S van Etten, Marcel M Verbeek, Jeroen van der Grond, Ronald Zielman, Sanneke van Rooden, Erik W van Zwet, Anna M van Opstal, Joost Haan, Steven M Greenberg, Mark A van Buchem, Marieke J H Wermer, Gisela M Terwindt
OBJECTIVE: To investigate CSF biomarkers in presymptomatic and symptomatic mutation carriers with hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D), a model for sporadic cerebral amyloid angiopathy, and to determine the earliest deposited form of β-amyloid (Aβ). METHODS: HCHWA-D mutation carriers and controls were enrolled in the cross-sectional EDAN (Early Diagnosis of Amyloid Angiopathy Network) study. The HCHWA-D group was divided into symptomatic carriers with a previous intracerebral hemorrhage and presymptomatic carriers...
January 10, 2017: Neurology
https://www.readbyqxmd.com/read/27898582/antithrombotic-therapy-in-patients-with-cerebral-microbleeds
#5
Duncan Wilson, David J Werring
PURPOSE OF REVIEW: Cerebral microbleeds (CMBs) are a radiological marker of cerebral small vessel disease corresponding to small haemosiderin foci identified by blood-sensitive MRI. CMBs are common in older community populations, and in individuals with ischaemic stroke or transient ischaemic attack (TIA), and intracerebral haemorrhage (ICH). We summarize how CMBs might contribute to assessing the future risk of ischaemic stroke and ICH to inform antithrombotic (antiplatelet or anticoagulant) decisions...
February 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/27893680/the-value-of-ezis-analysis-of-tc-99m-ecd-spect-on-identifying-cerebellar-hypoperfusion-in-a-patient-with-superficial-siderosis-a-case-report
#6
Cheng-Yu Wei, Tai-Yi Chen, Ian Shih, Pai-Yi Chiu, Guang-Uei Hung, Hiroshi Matsuda
INTRODUCTION: Brain perfusion single photon computed tomography (SPECT) is a functional imaging modality and has been widely utilized in evaluation of various kinds of neurological disorders. Easy z-score imaging system (eZIS) is a computer-assisted statistical analysis, based on the comparison with age-classified ethyl cysteinate dimer (ECD) normal database, which provides objectively interpretation of Tc-99m ECD brain perfusion SPECT.Here we presented a 64-year-old male with dizziness, spin sensation, nausea, and vomiting in the emergency room, and brain computed tomography scan showed only small hypodensity lesion in cerebellum...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27873743/aneurysmal-wall-imaging-in-a-case-of-cortical-superficial-siderosis-and-multiple-unruptured-aneurysms
#7
Bertrand Yalo, Raoul Pop, Ielyzaveta Zinchenko, Mihaela Diaconu, Salvatore Chibbaro, Monica Manisor, Valerie Wolff, Remy Beaujeux
We report a case of interhemispheric and bifrontal cortical superficial siderosis in association with two intracranial aneurysms. The patient had no clinical history suggestive of aneurysm rupture, no feature of amyloid angiopathy or other apparent etiology for cortical siderosis. We performed high resolution brain MRI with dark blood T1 sequences before and after IV contrast injection. An anterior communicating aneurysm showed partial wall enhancement on the posterior wall whereas a left posterior communicating aneurysm did not...
November 9, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27834748/early-magnetic-resonance-imaging-and-cognitive-markers-of-hereditary-cerebral-amyloid-angiopathy
#8
Sanneke van Rooden, Anna M van Opstal, Gerda Labadie, Gisela M Terwindt, Marieke J H Wermer, Andrew G Webb, Huub A M Middelkoop, Steven M Greenberg, Jeroen van der Grond, Mark A van Buchem
BACKGROUND AND PURPOSE: Early markers for cerebral amyloid angiopathy are largely unknown. We aimed to identify which magnetic resonance imaging (MRI) (performed at 7 and 3T) and cognitive markers are an early sign in (pre) symptomatic subjects with hereditary cerebral hemorrhage with amyloidosis-Dutch type. METHODS: Twenty-seven DNA-proven Dutch-type mutation carriers (15 symptomatic and 12 presymptomatic) (mean age of 45.9 years) and 33 controls (mean age of 45...
December 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27788692/deferiprone-reduces-hemosiderin-deposition-in-superficial-siderosis
#9
Pei-Hsin Kuo, Sheng-Han Kuo, Raymond Y Lo
No abstract text is available yet for this article.
October 28, 2016: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/27754910/superficial-siderosis-and-dural-ectasia-a-case-report
#10
Meabh O'Hare, Conor Fearon, Eoin C Kavanagh, Brian Murray, Timothy Lynch
No abstract text is available yet for this article.
October 18, 2016: Neurology
https://www.readbyqxmd.com/read/27723863/association-of-key-magnetic-resonance-imaging-markers-of-cerebral-small-vessel-disease-with-hematoma-volume-and-expansion-in-patients-with-lobar-and-deep-intracerebral-hemorrhage
#11
Gregoire Boulouis, Ellis S van Etten, Andreas Charidimou, Eitan Auriel, Andrea Morotti, Marco Pasi, Kellen E Haley, H Bart Brouwers, Alison M Ayres, Anastasia Vashkevich, Michael J Jessel, Kristin M Schwab, Anand Viswanathan, Steven M Greenberg, Jonathan Rosand, Joshua N Goldstein, M Edip Gurol
Importance: Hematoma expansion is an important determinant of outcome in spontaneous intracerebral hemorrhage (ICH) due to small vessel disease (SVD), but the association between the severity of the underlying SVD and the extent of bleeding at the acute phase is unknown to date. Objective: To investigate the association between key magnetic resonance imaging (MRI) markers of SVD (as per the Standards for Reporting Vascular Changes on Neuroimaging [STRIVE] guidelines) and hematoma volume and expansion in patients with lobar or deep ICH...
December 1, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27703444/prevalence-of-brain-mri-markers-of-hemorrhagic-risk-in-patients-with-stroke-and-atrial-fibrillation
#12
Christopher Karayiannis, Cathy Soufan, Ronil V Chandra, Thanh G Phan, Kitty Wong, Shaloo Singhal, Lee-Anne Slater, John Ly, Chris Moran, Velandai Srikanth
BACKGROUND AND PURPOSE: Cerebral microbleeds (CMBs), cortical superficial siderosis, white matter lesions (WML), and cerebral atrophy may signify greater bleeding risk particularly in patients in whom anticoagulation is to be considered. We investigated their prevalence and associations with stroke type in patients with stroke and atrial fibrillation (AF). MATERIALS AND METHODS: Cross-sectional sample, Monash Medical Centre (Melbourne, Australia) between 2010 and 2013, with brain MRI...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27694268/cortical-superficial-siderosis-predicts-early-recurrent-lobar-hemorrhage
#13
Duangnapa Roongpiboonsopit, Andreas Charidimou, Christopher M William, Arne Lauer, Guido J Falcone, Sergi Martinez-Ramirez, Alessandro Biffi, Alison Ayres, Anastasia Vashkevich, Oluwole O Awosika, Jonathan Rosand, M Edip Gurol, Scott B Silverman, Steven M Greenberg, Anand Viswanathan
OBJECTIVE: To identify predictors of early lobar intracerebral hemorrhage (ICH) recurrence, defined as a new ICH within 6 months of the index event, in patients with cerebral amyloid angiopathy (CAA). METHODS: Participants were consecutive survivors (age ≥55 years) of spontaneous symptomatic probable or possible CAA-related lobar ICH according to the Boston criteria, drawn from an ongoing single-center cohort study. Neuroimaging markers ascertained in CT or MRI included focal (≤3 sulci) or disseminated (>3 sulci) cortical superficial siderosis (cSS), acute convexity subarachnoid hemorrhage (cSAH), cerebral microbleeds, white matter hyperintensities burden and location, and baseline ICH volume...
November 1, 2016: Neurology
https://www.readbyqxmd.com/read/27685823/superficial-siderosis
#14
T Abkur, S Looby, T Counihan
Herein, we describe a case of 69 year old man who presented with gradual bilateral hearing impairment and unsteadiness. Examination showed bilateral sensorineural deafness and cerebellar ataxia. Neuroimaging revealed a rim of hypointensity surrounding the brain stem, superficial cerebellar fissures and extending into the cervical spinal cord consistent with the diagnosis of superficial siderosis (SS). Investigations failed to identify any reversible cause for the condition.
March 10, 2016: Irish Medical Journal
https://www.readbyqxmd.com/read/27633808/superficial-siderosis-after-germinal-matrix-hemorrhage
#15
U Yilmaz, S Meyer, L Gortner, H Körner, M Türkyilmaz, A Simgen, W Reith, R Mühl-Benninghaus
BACKGROUND AND PURPOSE: Germinal matrix hemorrhage is a frequent complication of prematurity and can be associated with adverse neurodevelopmental outcome, depending on its severity. In addition to parenchymal damage, intraventricular residues of hemorrhage and hydrocephalus MR imaging findings include superficial siderosis. The purpose of this study was to investigate the prevalence and location of superficial siderosis in patients with a history of germinal matrix hemorrhage. MATERIALS AND METHODS: We retrospectively identified patients with a history of germinal matrix hemorrhage who underwent MR imaging in our institution between 2008 and 2016...
December 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/27613583/microbleeds-on-mri-are-associated-with-microinfarcts-on-autopsy-in-cerebral-amyloid-angiopathy
#16
Arne Lauer, Susanne J van Veluw, Christopher M William, Andreas Charidimou, Duangnapa Roongpiboonsopit, Anastasia Vashkevich, Alison Ayres, Sergi Martinez-Ramirez, Edip M Gurol, Geert Jan Biessels, Matthew Frosch, Steven M Greenberg, Anand Viswanathan
OBJECTIVES: To identify in vivo MRI markers that might correlate with cerebral microinfarcts (CMIs) on autopsy in patients with cerebral amyloid angiopathy (CAA). METHODS: We included patients with neuropathologic evidence of CAA on autopsy and available antemortem brain MRI. Clinical characteristics and in vivo MRI markers of CAA-related small vessel disease were recorded, including white matter hyperintensities, cerebral microbleeds, cortical superficial siderosis, and centrum semiovale perivascular spaces...
October 4, 2016: Neurology
https://www.readbyqxmd.com/read/27567848/cerebrospinal-fluid-alzheimer-s-disease-biomarkers-in-isolated-supratentorial-cortical-superficial-siderosis
#17
Dimitri Renard, Audrey Gabelle, Christophe Hirtz, Christophe Demattei, Eric Thouvenot, Sylvain Lehmann
We evaluated cerebrospinal fluid amyloid-β 1-40 (Aβ40), amyloid-β 1-42 (Aβ42), total and phosphorylated-tau (t-tau and p-tau) in patients with symptomatic isolated cortical supratentorial superficial siderosis (SS), by prospectively recruiting ten patients with SS in the absence of pre-existing cognitive dysfunction, and comparing biomarkers with lobar hematoma cerebral amyloid angiopathy patients (LH-CAA, n = 13), Alzheimer's disease patients (AD, n = 42), and controls (n = 16). Compared to controls, SS patients showed statistically significant higher t-tau (p = 0...
October 18, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27534713/cortical-superficial-siderosis-prevalence-and-biomarker-profile-in-a-memory-clinic-population
#18
Sara Shams, Juha Martola, Andreas Charidimou, Lena Cavallin, Tobias Granberg, Mana Shams, Yngve Forslin, Peter Aspelin, Maria Kristoffersen-Wiberg, Lars-Olof Wahlund
OBJECTIVE: To gain further insight into cortical superficial siderosis (cSS), a new hemorrhagic neuroimaging marker of cerebral amyloid angiopathy (CAA), and to investigate the clinical, neuroimaging, genetic, and CSF biomarker profile of cSS in a large, consecutive memory clinic series. METHODS: We included 1,504 memory clinic patients undergoing dementia investigation including a brain MRI in our center. Routine CSF biomarker analysis was performed in 1,039 patients and APOE genotyping in 520 patients...
September 13, 2016: Neurology
https://www.readbyqxmd.com/read/27507863/cerebral-microbleeds-and-cortical-superficial-siderosis-in-patients-presenting-with-minor-cerebrovascular-events
#19
Charlotte Zerna, Jayesh Modi, Lisa Bilston, Ashkan Shoamanesh, Shelagh B Coutts, Eric E Smith
BACKGROUND AND PURPOSE: Transient focal neurological episodes occur in cerebral amyloid angiopathy (CAA) and can mimic transient ischemic attack (TIA). Risk factors and outcomes of minor ischemic stroke or TIA might differ in patients with and without cerebral microbleeds (CMBs), including CAA-consistent lobar CMB. METHODS: Baseline magnetic resonance imaging (MRI) was analyzed for CMBs and cortical superficial siderosis in 416 patients in the prospective computed tomography and MRI in the CATCH study (Triage of TIA and Minor Cerebrovascular Events to Identify High Risk Patients)...
September 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27498096/superficial-siderosis-associated-with-peripheral-autonomic-failure-and-tetraventricular-hydrocephalus-a-case-report
#20
Samir Abu Rumeileh, Valentina Favoni, Francesco Toni, Giulia Pierangeli, Federico Oppi, Giovanna Calandra-Buonaura, David Milletti, Monica Maffei, Luigi Cirillo, Raffaele Agati, Giorgio Palandri, Pietro Cortelli
We describe the case of a man whose initial clinical presentation included sensorineural hearing loss and orthostatic hypotension. The patient was diagnosed with superficial siderosis associated with peripheral autonomic failure and tetraventricular hydrocephalus.
August 6, 2016: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
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