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Osteochondritis

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https://www.readbyqxmd.com/read/28325693/surgical-technique-and-clinical-outcomes-of-retrograde-osteochondral-autograft-transfer-for-osteochondral-lesions-of-the-tibial-plateau
#1
Hiromitsu Yabumoto, Yasuaki Nakagawa, Shogo Mukai, Takahiko Saji, Takashi Nakamura
PURPOSE: To present the surgical technique, clinical outcomes, and poor prognostic factors of arthroscopic retrograde osteochondral autograft transfer of the tibial plateau. METHODS: Twelve patients (6 men, 6 women; mean age, 38.7 years) with tibial plateau osteochondral lesions underwent surgery. The primary diseases were osteonecrosis in 4 cases, cartilage injuries in 6, and postfractures of the tibial plateau in 2. Clinical outcomes were evaluated preoperatively and postoperatively according to the International Knee Documentation Committee score and the Japanese Orthopaedic Association score...
March 18, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28324121/-impingement-syndrome-of-the-ankle
#2
R-I Milos, L B Fritz, C Schueller-Weidekamm
Impingement syndrome of the ankle is a clinical diagnosis caused posttraumatically by overuse due to repetitive mechanical loading or the presence of predisposing anatomical variants. Ankle impingement syndrome is characterized by chronic pain and limited range of movement caused by mechanical compression of bony or soft tissues within the joint compartments. Ankle impingement syndrome is classified according to the various anatomical locations around the tibiotalar joint as anterior, anterolateral, anteromedial, posterior or posteromedial...
March 21, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28321431/osteochondritis-dissecans-of-the-humeral-capitellum-in-young-athletes-comparison-between-baseball-players-and-gymnasts
#3
Shiro Kajiyama, Satoshi Muroi, Hiroyuki Sugaya, Norimasa Takahashi, Keisuke Matsuki, Nobuaki Kawai, Makoto Osaki
BACKGROUND: Osteochondritis dissecans (OCD) lesions are often observed in the humeral capitellum both in young baseball players and gymnasts. It is generally believed that capitellar OCD in baseball players can be seen on an anteroposterior (AP) radiograph with the elbow in 45° of flexion. However, the mechanism of injury seems to be different in baseball players and gymnasts. Repetitive valgus overload with the elbow in flexion is believed to be the cause of capitellar OCD lesions in baseball players, whereas weightbearing with the elbow in extension may be the cause of OCD in gymnasts...
March 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28320425/patient-compliance-with-touchdown-weight-bearing-after-microfracture-treatment-of-talar-osteochondral-lesions
#4
Gökhan Polat, Gökhan Karademir, Ekin Akalan, Mehmet Aşık, Mehmet Erdil
BACKGROUND: The aim of this study was to prospectively evaluate the compliance of our patients with a touchdown weight bearing (without supporting any weight on the affected side by only touching the plantar aspect of the foot to the ground to maintain balance to protect the affected side from mechanical loading) postoperative rehabilitation protocol after treatment of talar osteochondral lesion (TOL). METHODS: Fourteen patients, who had been treated with arthroscopic debridement and microfracture, were followed prospectively...
March 20, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28319248/cyclic-tensile-strain-enhances-human-mesenchymal-stem-cell-smad-2-3-activation-and-tenogenic-differentiation-in-anisotropic-collagen-glycosaminoglycan-scaffolds
#5
W G Grier, A S Moy, B A Harley
Stem cell research arose from the need to explore new therapeutic possibilities for intractable and lethal diseases. Although musculoskeletal disorders are basically nonlethal, their high prevalence and relative ease of performing clinical trials have facilitated the clinical application of stem cells in this field. However, few reliable clinical studies have been published, despite the plethora of in vitro and preclinical studies in stem cell research for regenerative medicine in the musculoskeletal system...
March 20, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/28319157/subchondral-bone-histology-and-grading-in-osteoarthritis
#6
Olli-Matti Aho, Mikko Finnilä, Jerome Thevenot, Simo Saarakkala, Petri Lehenkari
OBJECTIVE: Osteoarthritis (OA) has often regarded as a disease of articular cartilage only. New evidence has shifted the paradigm towards a system biology approach, where also the surrounding tissue, especially bone is studied more vigorously. However, the histological features of subchondral bone are only poorly characterized in current histological grading scales of OA. The aim of this study is to specifically characterize histological changes occurring in subchondral bone at different stages of OA and propose a simple grading system for them...
2017: PloS One
https://www.readbyqxmd.com/read/28302318/regional-differences-of-tibial-and-femoral-cartilage-in-the-chondrocyte-gene-expression-immunhistochemistry-and-composite-in-different-stages-of-osteoarthritis
#7
A Lahm, D Dabravolski, H Spank, H Merk, J Esser, R Kasch
The function of articular cartilage as an avascular tissue is mainly served by collagen type II and proteoglycan molecules. Within this matrix homeostasis between production and breakdown of the matrix is exceptionally sensitive. The current study was conducted to identify regional differences in specific alterations in cartilage composition during the osteoarthritic process of the human knee joint. Therefor the changes in the expression of the key molecules of the extracellular matrix were measured in dependence of the anatomical side (femoral vs tibial) and associated with immunohistochemistry and quantitative measurement...
February 24, 2017: Tissue & Cell
https://www.readbyqxmd.com/read/28299386/high-rate-of-recurrent-patellar-dislocation-in-skeletally-immature-patients-a-long-term-population-based-study
#8
Thomas L Sanders, Ayoosh Pareek, Timothy E Hewett, Michael J Stuart, Diane L Dahm, Aaron J Krych
PURPOSE: Patellar dislocation can occur in isolation or be associated with chronic instability. The goals of this study are to describe the rate and factors associated with additional patellar instability events (ipsilateral recurrence and contralateral dislocation), as well as the development of patellofemoral arthritis in patients who are skeletally immature at the time of first patellar dislocation. METHODS: The study included a population-based cohort of 232 skeletally immature patients who experienced a first-time lateral patellar dislocation between 1990 and 2010...
March 15, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28290308/osteochondral-lesions-and-partial-fractures-of-the-talus-in-paleopathology
#9
REVIEW
Yves Darton, Véronique Gallien, Élise Henrion, Mathias Dupuis, Isabelle Richard
No abstract text is available yet for this article.
March 2017: International Journal of Paleopathology
https://www.readbyqxmd.com/read/28285000/reinforcement-of-articular-cartilage-with-a-tissue-interpenetrating-polymer-network-reduces-friction-and-modulates-interstitial-fluid-load-support
#10
Benjamin G Cooper, Taylor Lawson, Brian D Snyder, Mark W Grinstaff
OBJECTIVE: Osteoarthritis is associated with increased articular cartilage hydraulic permeability and decreased maintenance of high interstitial fluid load support during articulation, resulting in increased friction on the cartilage solid matrix. This study assesses frictional response following in situ synthesis of an interpenetrating polymer network designed to mimic glycosaminoglycans depleted during osteoarthritis. METHODS: Cylindrical osteochondral explants containing various interpenetrating polymer concentrations were subjected to a torsional friction test under unconfined creep compression...
March 8, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28277417/comparison-of-healing-intra-articular-fracture-of-distal-femur-using-a-kirschner-wire-and-autologous-fibrin-glue-in-an-animal-model
#11
Mohammad R Azarpira, Kasra Vazani, Maryam Ayatollahi, Negar Azarpira, Maryam Kaviani
Considering different surgical techniques for the fixation of osteochondral intra-articular fracture, the present study aimed to compare the efficacy of autologous fibrin glue and Kirschner wire (KW) on an osteochondral fracture in the left lateral condyle of Dutch rabbits with a control group. After 6 weeks, macroscopic and microscopic evaluation showed that autologous fibrin glue is easier and faster with a higher number of bone trabecula (P<0.05), whereas the healing rate and cellularity of the healing site were not different between the two groups (KW and glue)...
March 8, 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28276998/collagen-pva-aligned-nanofiber-on-collagen-sponge-as-bi-layered-scaffold-for-surface-cartilage-repair
#12
Hsin-Yi Lin, Wen-Chi Tsai, Shih-Hsing Chang
Researchers have made bi-layered scaffolds but mostly for osteochondral repairs. The anatomic structure of human cartilage has different zones and that each has varying matrix morphology and mechanical properties is often overlooked. Two bi-layered collagen-based composites were made to replicate the superficial and transitional zones of an articular cartilage. Aligned and random collagen-PVA nanofibers were electrospun onto a freeze-dried collagen sponge to make the aligned and random composites, respectively...
May 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28272938/comparison-of-2-different-formulations-of-artificial-bone-for-a-hybrid-implant-with-a-tissue-engineered-construct-derived-from-synovial-mesenchymal-stem-cells
#13
Kazunori Shimomura, Yu Moriguchi, Ryosuke Nansai, Hiromichi Fujie, Wataru Ando, Shuji Horibe, David A Hart, Alberto Gobbi, Hideki Yoshikawa, Norimasa Nakamura
BACKGROUND: Previously, we developed a hybrid implant composed of hydroxyapatite (HA)-based artificial bone coupled with a mesenchymal stem cell (MSC)-based scaffold-free tissue-engineered construct (TEC) and demonstrated its feasibility for osteochondral repair. Beta-tricalcium phosphate (βTCP) may be a promising alternative to HA, as it is a highly biocompatible material and is resorbed more rapidly than HA in vivo. HYPOTHESIS: A βTCP-based hybrid TEC implant will exhibit superior osteochondral repair when directly compared with an HA-based hybrid implant, as tested using a rabbit osteochondral defect model...
March 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28272928/prospective-clinical-and-radiographic-outcomes-after-concomitant-anterior-cruciate-ligament-reconstruction-and-meniscal-allograft-transplantation-at-a-mean-5-year-follow-up
#14
Bryan M Saltzman, Maximilian A Meyer, Alexander E Weber, Sarah G Poland, Adam B Yanke, Brian J Cole
BACKGROUND: Concomitant anterior cruciate ligament reconstruction and meniscal allograft transplantation (ACLR/MAT) has demonstrated short-term success in small, retrospective cohort studies. Patient- and disease-specific predictors of success after ACLR/MAT are largely unknown. PURPOSE: To (1) prospectively evaluate the subjective and objective clinical and radiographic outcomes after ACLR/MAT and (2) conduct a subgroup analysis to identify patient- or disease-related factors that correlate with failure...
March 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28271091/osteochondritis-dissecans-of-the-humeral-head-a-case-report-and-review-of-the-literature
#15
Davod Jafari, Hooman Shariatzadeh, Farid Najd Mazhar, Mohammad Ali Okhovatpour, Mehran Razavipour
Osteochondritis dissecans (OCD) is a common joint disorder in knee, ankle and elbow, however it can be rarely found in glenohumeral joint. In this study, we report an asymptomatic case of humeral head OCD, which was detected incidentally following a trauma. X-rays showed an area of lucency around an oval bony fragment measuring about 1 cm on the superior aspect of the humeral head. However, the patient was pain-free and the shoulder range of motion was normal.
January 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/28266690/lengthening-primary-cilia-enhances-cellular-mechanosensitivity
#16
G-I Im
Stem cell research arose from the need to explore new therapeutic possibilities for intractable and lethal diseases. Although musculoskeletal disorders are basically nonlethal, their high prevalence and relative ease of performing clinical trials have facilitated the clinical application of stem cells in this field. However, few reliable clinical studies have been published, despite the plethora of in vitro and preclinical studies in stem cell research for regenerative medicine in the musculoskeletal system...
February 21, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/28263667/one-step-treatment-for-patellar-cartilage-defects-with-a-cell-free-osteochondral-scaffold
#17
Francesco Perdisa, Giuseppe Filardo, Andrea Sessa, Maurizio Busacca, Stefano Zaffagnini, Maurilio Marcacci, Elizaveta Kon
BACKGROUND: The treatment of symptomatic cartilage defects of the patella is particularly challenging, and no gold standard is currently available. PURPOSE: To evaluate the clinical results of a biphasic cell-free collagen-hydroxyapatite scaffold and to evaluate osteochondral tissue regeneration with magnetic resonance imaging (MRI). STUDY DESIGN: Case series; Level of evidence, 4. METHODS: Thirty-four patients (18 men and 16 women; mean ± SD: age, 30...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28261617/repair-of-osteochondral-defects-using-human-umbilical-cord-wharton-s-jelly-derived-mesenchymal-stem-cells-in-a-rabbit-model
#18
Shuyun Liu, Yanhui Jia, Mei Yuan, Weimin Guo, Jingxiang Huang, Bin Zhao, Jiang Peng, Wenjing Xu, Shibi Lu, Quanyi Guo
Umbilical cord Wharton's jelly-derived mesenchymal stem cell (WJMSC) is a new-found mesenchymal stem cell in recent years with multiple lineage potential. Due to its abundant resources, no damage procurement, and lower immunogenicity than other adult MSCs, WJMSC promises to be a good xenogenous cell candidate for tissue engineering. This in vivo pilot study explored the use of human umbilical cord Wharton's jelly mesenchymal stem cells (hWJMSCs) containing a tissue engineering construct xenotransplant in rabbits to repair full-thickness cartilage defects in the femoral patellar groove...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28259751/cadaver-study-of-anatomic-landmark-identification-for-placing-ankle-arthroscopy-portals
#19
Benjamin Scheibling, Guillaume Koch, Philippe Clavert
BACKGROUND: Arthroscopy-assisted surgery is now widely used at the ankle for osteochondral lesions of the talus, anterior and posterior impingement syndromes, talocrural or subtalar fusion, foreign body removal, and ankle instability. Injuries to the vessels and nerves may occur during these procedures. OBJECTIVE: To determine whether ultrasound topographic identification of vulnerable structures decreased the risk of iatrogenic injuries to vessels, nerves, and tendons and influenced the distance separating vulnerable structures from the arthroscope introduced through four different portals...
March 1, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28259463/properties-of-the-cartilage-layer-from-the-cam-type-hip-impingement-deformity
#20
Andrew D Speirs, Paul E Beaulé, Adrian Huang, Hanspeter Frei
Femoro-acetabular impingement (FAI) is associated with significant acetabular cartilage damage and degenerative arthritis. To understand the contact stress and thus biomechanical mechanisms that may contribute to degeneration, the material behaviour of the cartilage layer is required. The objective of this study is to determine the fibril-reinforced poroelastic properties and composition of cartilage from cam deformities and to compare to those of normal cartilage. Patients undergoing surgical treatment of a symptomatic cam FAI deformity were recruited from the clinical practice of one of the authors...
February 21, 2017: Journal of Biomechanics
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