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Reaction time testing in neuropsychology

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https://www.readbyqxmd.com/read/29126934/neuropsychological-functioning-in-military-pesticide-applicators-from-the-gulf-war-effects-on-information-processing-speed-attention-and-visual-memory
#1
Kimberly Sullivan, Maxine Krengel, William Bradford, Callie Stone, Terri Ann Thompson, Timothy Heeren, Roberta F White
1991 Gulf War (GW) veterans continue to experience debilitating cognitive and mood problems more than two decades following their return from deployment. Suspected causes for these cognitive complaints include additive and/or synergistic effects of the varying combinations of exposures to chemicals in theater, including pesticides and pyridostigmine bromide (PB) pills. This study was undertaken to address one of the key recommendations of the US Department of Defense Environmental Exposure Report on Pesticides, which was to conduct an epidemiological study to further evaluate the role of neurotoxicant exposures in the expression of central nervous system symptoms reported by GW veterans...
November 7, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/29073608/neuropsychological-training-of-attention-improves-ms-related-fatigue-results-of-a-randomized-placebo-controlled-double-blind-pilot-study
#2
Peter Flachenecker, Heike Meissner, Rebecca Frey, Wolfgang Guldin
BACKGROUND: Attentional deficits may be pathophysiologically relevant in MS-associated fatigue. PATIENTS AND METHODS: Thirty MS patients with fatigue and attentional deficits in neuropsychological testing participated in this randomized, placebo-controlled, double-blind trial. The intervention group (IG; n = 14) was treated with 10 h of computerized, specific neuropsychological training performing simple reaction time tasks, whereas the control group (CG; n = 16) also runs through computerized, but unspecific neuropsychological training using tasks without time components...
October 26, 2017: European Neurology
https://www.readbyqxmd.com/read/29063516/paroxetine-and-fluconazole-therapy-for-hiv-associated-neurocognitive-impairment-results-from-a-double-blind-placebo-controlled-trial
#3
Ned Sacktor, Richard L Skolasky, Richard Moxley, Sheng Wang, Michelle M Mielke, Cynthia Munro, Joseph Steiner, Avindra Nath, Norman Haughey, Justin McArthur
Paroxetine and fluconazole have neuroprotective effects in an in vitro model of HIV protein-mediated neuronal injury. This study evaluated the safety, tolerability, and efficacy of both paroxetine and fluconazole for the treatment of HIV-associated neurocognitive disorder (HAND). A 24-week randomized double-blind, placebo-controlled 2 × 2 factorial design study was used. HIV+ individuals with cognitive impairment were enrolled in the 24-week trial. Participants were randomly assigned to one of four groups: (1) paroxetine 20 mg/day, (2) fluconazole 100 mg every 12 h, (3) paroxetine and fluconazole, or (4) placebo...
October 23, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/29052999/impulsivity-and-compulsivity-in-internet-gaming-disorder-a-comparison-with-obsessive-compulsive-disorder-and-alcohol-use-disorder
#4
Yeon-Jin Kim, Jae A Lim, Ji Yoon Lee, Sohee Oh, Sung Nyun Kim, Dai Jin Kim, Jong Eun Ha, Jun Soo Kwon, Jung-Seok Choi
Background and aims Internet gaming disorder (IGD) is characterized by a loss of control and a preoccupation with Internet games leading to repetitive behavior. We aimed to compare the baseline neuropsychological profiles in IGD, alcohol use disorder (AUD), and obsessive-compulsive disorder (OCD) in the spectrum of impulsivity and compulsivity. Methods A total of 225 subjects (IGD, N = 86; AUD, N = 39; OCD, N = 23; healthy controls, N = 77) were administered traditional neuropsychological tests including Korean version of the Stroop Color-Word test and computerized neuropsychological tests, including the stop signal test (SST) and the intra-extra dimensional set shift test (IED)...
October 20, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28993113/the-cognitive-impact-of-chronic-low-back-pain-positive-effect-of-multidisciplinary-pain-therapy
#5
Marcus Schiltenwolf, Michael Akbar, Eva Neubauer, Simone Gantz, Herta Flor, Andreas Hug, Haili Wang
OBJECTIVES: Little is known about the affected cognitive problems in chronic low back pain patients. For this patient cohort research mostly focused on memory of pain, rather than cognitive difficulties related to pain. Chronic pain may be associated with specific (yet undefined) cognitive deficits that affect everyday behaviour. We set out to compare the cognitive function of patients with chronic low back pain (cLBP) in the course of multidisciplinary pain treatments before and after therapy...
October 6, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/28984621/the-effects-of-exercise-on-cognitive-function-and-brain-plasticity-a-feasibility-trial
#6
Joyce Gomes-Osman, Danylo F Cabral, Carrie Hinchman, Ali Jannati, Timothy P Morris, Alvaro Pascual-Leone
BACKGROUND: Exercise-mediated cognitive improvements can be at least partly attributed to neuroplastic changes in the nervous system, and may be influenced by the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene. Transcranial magnetic stimulation (TMS) can be used to assess mechanisms of plasticity in humans noninvasively. OBJECTIVES: To assess the feasibility of evaluating the effects of short-term regular exercise on cognitive performance, and to evaluate the relationship between these effects, TMS measures of plasticity, and BDNF Met carrier status in young healthy sedentary adults...
2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28981565/validity-of-a-computerized-cognitive-battery-in-children-and-adolescents-with-neurological-diagnoses
#7
Vickie Plourde, Marianne Hrabok, Elisabeth M S Sherman, Brian L Brooks
Objective: Little is known about the validity of computerized cognitive batteries, such as CNS Vital Signs (CNSVS), in pediatric patients. The purpose of this study was to examine convergent and divergent validity of the CNSVS in a clinical pediatric sample with neurological diagnoses. Method: Participants included 123 pediatric patients assessed in a tertiary care setting as part of clinical care. CNSVS (Memory, Psychomotor Speed, Reaction Time, Complex Attention, and Cognitive Flexibility domains, and a Neurocognition Index) and paper-and-pencil neuropsychological measures assessing learning, memory, processing speed, reaction time, attention, and executive functioning were administered...
August 1, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28935224/the-test-retest-reliability-of-three-computerized-neurocognitive-tests-used-in-the-assessment-of-sport-concussion
#8
Jacob E Resch, Mathew W Schneider, C Munro Cullum
Computerized neurocognitive tests (CNTs) are widely used at all competitive levels of sport to assess sport concussion (SC). Whereas there are multiple CNTs available, little is known about how some of the most popular platforms compare. The purpose of this study was to investigate the test-retest reliability of the Automated Neuropsychological Assessment Metrics (ANAM), Concussion Vital Signs (CVS) and the Immediate Postconcussion and Cognitive Testing battery (ImPACT) using clinically relevant time points in healthy college-age participants...
September 18, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28914216/-driving-with-alzheimer-s-disease
#9
M Jacobs, E P 't Hart, R A C Roos
OBJECTIVE: To summarise the available literature on driving with Alzheimer's disease (AD) and to investigate the relationship between driving and cognitive functioning. DESIGN: Literature review. METHOD: A systematic search of the electronic databases PubMed/MEDLINE was conducted to select the relevant literature on the driving competence of patients with Alzheimer's disease. RESULTS: A total of 31 studies were selected that investigated driving competence in AD using either an on-road driving assessment or a driving simulator...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28889832/intra-individual-cognitive-variability-an-examination-of-anam4-tbi-mil-simple-reaction-time-data-from-service-members-with-and-without-mild-traumatic-brain-injury
#10
Wesley R Cole, Emma Gregory, Jacques P Arrieux, F Jay Haran
OBJECTIVES: The Automated Neuropsychological Assessment Metrics 4 TBI-MIL (ANAM4) is a computerized cognitive test often used in post-concussion assessments with U.S. service members (SMs). Existing evidence, however, remains mixed regarding ANAM4's ability to identify cognitive issues following mild traumatic brain injury (mTBI). Studies typically examine ANAM4 by comparing mean scores to baseline or normative scores. A more fine-grained approach involves examining inconsistency within an individual's performance...
September 11, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28783930/the-relationship-between-the-snap-25-polymorphism-and-omission-errors-in-korean-children-with-attention-deficit-hyperactivity-disorder
#11
Eunjoo Kim, Dong-Ho Song, Nam-Wook Kim, In-Jung Sohn, Keun-Ah Cheon
Objective: This study aimed to investigate the association between the synaptosomal-associated protein 25 kDa (SNAP-25) genotype and performance on the continuous performance test (CPT) in Korean children with attention-deficit/hyperactivity disorder (ADHD). Methods: Eighty-seven children with ADHD (mean age, 9.23±1.99 years) participated in this study. Omission errors, commission errors, reaction time, and reaction time variability on the CPT were analyzed. The single-nucleotide polymorphism (SNP) rs3746544 (1065 T>G) of SNAP-25 was genotyped to examine the association with CPT performance...
August 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28780923/assessment-of-cognitive-function-in-patients-with-metastatic-cancer-are-we-using-the-right-tools
#12
Geana Paula Kurita, Marlene Sandvad, Lena Lundorff, Cibele Andrucioli De Mattos-Pimenta, Jette Højsted, Per Sjøgren
OBJECTIVE: This study aimed at analyzing the validity and reliability of the continuous reaction time (CRT) test, the finger-tapping test (FTT), the Digit Span Test (DST), the Trail Making Test - part B (TMTB), and the Mini-Mental State Examination (MMSE) in patients with metastatic cancer. METHOD: Eighty adult patients and 81 healthy controls were assessed between July of 2010 and November of 2015. The neuropsychological tests were analyzed regarding construct/discriminant/criterion validity and reliability...
August 7, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28759268/relationship-between-neuropsychological-tests-and-driver-s-license-renewal-tests-in-parkinson-s-disease
#13
Dolors Badenes, Maite Garolera, Laura Casas, Juan Carlos Cejudo-Bolivar, Silvia Zaragoza, Noemi Calzado, Miquel Aguilar
OBJECTIVE: To determine whether the standard Spanish driving test (ASDE test) was able to identify patients with Parkinson's disease (PD) at risk of unsafe driving and to examine the relationship between the ASDE test and the Useful Field of View (UFOV) as well as with a battery of neuropsychological tests in drivers with PD. METHODS: Thirty-seven patients with PD and 33 controls matched by age and education level were included in an observational study. All participants were active drivers and patients with PD underwent study procedures after taking the medication in the "on" period...
July 31, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28745063/home-based-step-training-using-videogame-technology-in-people-with-parkinson-s-disease-a-single-blinded-randomised-controlled-trial
#14
Jooeun Song, Serene S Paul, Maria Joana D Caetano, Stuart Smith, Leland E Dibble, Rachelle Love, Daniel Schoene, Jasmine C Menant, Cathie Sherrington, Stephen R Lord, Colleen G Canning, Natalie E Allen
OBJECTIVES: To determine whether 12-week home-based exergame step training can improve stepping performance, gait and complementary physical and neuropsychological measures associated with falls in Parkinson's disease. DESIGN: A single-blinded randomised controlled trial. SETTING: Community (experimental intervention), university laboratory (outcome measures). SUBJECTS: Sixty community-dwelling people with Parkinson's disease...
July 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28700954/cognitive-and-motor-reaction-times-in-obstructive-sleep-apnea-syndrome-a-study-based-on-computerized-measures
#15
Maria Devita, Sonia Montemurro, Andrea Zangrossi, Sara Ramponi, Maurizio Marvisi, Daniele Villani, Maria Clara Raimondi, Paola Merlo, Maria Luisa Rusconi, Sara Mondini
Obstructive Sleep Apnea Syndrome (OSAS) is mainly associated with executive dysfunction. Although delayed reaction times (RTs) in patients with OSAS have been reported, sensitivity of processing speed has not been adequately assessed. This study suggests sensitive and reliable measures to clarify whether different components of information processing speed, i.e. cognitive and motor responses, are equally impaired in OSAS. Thirty-three patients with OSAS were compared with thirty healthy controls. The MoCA test was administered to assess participants' global neuropsychological profile...
July 9, 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28632037/construct-and-concurrent-validity-of-the-cambridge-neuropsychological-automated-tests-in-portuguese-older-adults-without-neuropsychiatric-diagnoses-and-with-alzheimer-s-disease-dementia
#16
Marta Matos Gonçalves, Maria Salomé Pinho, Mário R Simões
We aimed to analyze the construct and concurrent validity of the Rapid Visual Information Processing (RVP), Paired Associates Learning (PAL), Reaction Time (RTI), and Spatial Working Memory (SWM) tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB®). Inclusion criteria were checked in a first session. The CANTAB and additional pencil-and-paper tests were administered within 1 week. The participants (aged 69-96 years) were 137 Portuguese adults without neuropsychiatric diagnoses and 37 adults with mild-to-moderate Alzheimer's disease dementia...
February 28, 2017: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
https://www.readbyqxmd.com/read/28631988/evidence-of-practice-effect-in-cantab-spatial-working-memory-test-in-a-cohort-of-patients-with-mild-cognitive-impairment
#17
Federica Cacciamani, Nicola Salvadori, Paolo Eusebi, Viviana Lisetti, Elisa Luchetti, Paolo Calabresi, Lucilla Parnetti
The Cambridge Neuropsychological Test Automated Battery (CANTAB) is a system of neuropsychological tests frequently used to track the progression of cognitive deficits in mild cognitive impairment (MCI) and Alzheimer's disease (AD). We investigated test-retest reliability in seven CANTAB tests. Twenty-five MCI patients, with either AD-like or conflicting/normal cerebrospinal fluid profiles underwent three testing sessions at 6-month intervals, including the following tests: Reaction Time and Rapid Visual Information Processing (assessing attention and reaction times); Delayed Matching-to-Sample, Paired Associates Learning, Spatial Recognition Memory and Pattern Recognition Memory (assessing memory); Spatial Working Memory (assessing executive functions)...
February 22, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28601572/corpus-callosum-atrophy-as-a-marker-of-clinically-meaningful-cognitive-decline-in-secondary-progressive-multiple-sclerosis-impact-on-employment-status
#18
Athanasios Papathanasiou, Lambros Messinis, Petros Zampakis, Panagiotis Papathanasopoulos
Cognitive impairment in Multiple Sclerosis (MS) is more frequent and pronounced in secondary progressive MS (SPMS). Cognitive decline is an important predictor of employment status in patients with MS. Magnetic Resonance Imaging (MRI) markers have been used to associate tissue damage with cognitive dysfunction. The aim of the study was to designate the MRI marker that predicts cognitive decline in SPMS and explore its effect on employment status. 30 SPMS patients and 30 healthy participants underwent neuropsychological assessment using the Trail Making Test (TMT) parts A and B, semantic and phonological verbal fluency task and a computerized cognitive screening battery (Central Nervous System Vital Signs)...
June 7, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28596126/reaction-time-processing-speed-and-sustained-attention-in-schizophrenia-impact-on-social-functioning
#19
Guillermo Lahera, Alicia Ruiz, Antía Brañas, María Vicens, Arantxa Orozco
INTRODUCTION: Previous studies have linked processing speed with social cognition and functioning of patients with schizophrenia. A discriminant analysis is needed to determine the different components of this neuropsychological construct. This paper analyzes the impact of processing speed, reaction time and sustained attention on social functioning. MATERIAL AND METHODS: 98 outpatients between 18 and 65 with DSM-5 diagnosis of schizophrenia, with a period of 3 months of clinical stability, were recruited...
October 2017: Revista de Psiquiatrí́a y Salud Mental
https://www.readbyqxmd.com/read/28570092/the-effect-of-physical-exercise-after-a-concussion-a-systematic-review-and-meta-analysis
#20
Avtar Lal, Stephanie A Kolakowsky-Hayner, Jamshid Ghajar, Maya Balamane
BACKGROUND: Data evaluating the role of exercise in patients with a concussion are contradictory. Studies have reported improvement in the Post-Concussion Symptom Scale (PCSS) score, whereas others showed no effect on the PCSS score. PURPOSE: To conduct a systematic review and meta-analysis on the role of physical exercise on different outcomes in patients with a concussion. STUDY DESIGN: Systematic review and meta-analysis. METHODS: A search of 5 databases from the earliest available date to September 30, 2016, and a hand search of a few articles were performed...
June 1, 2017: American Journal of Sports Medicine
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