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https://www.readbyqxmd.com/read/28320100/drosophila-melanogaster-a-potential-model-organism-for-identification-of-pharmacological-properties-of-plants-plant-derived-components
#1
REVIEW
Komal Panchal, Anand K Tiwari
Plants/plant-derived components have been used from ancient times to treat/cure several human diseases. Plants and their parts possess several chemical components that play the vital role in the improvement of human health and their life expectancy. Allopathic medicines have been playing a key role in the treatment of several diseases. Though allopathic medicines provide fast relief, long time consumption cause serious health concerns such as hyperallergic reactions, liver damage, etc. So, the study of medicinal plants which rarely cause any side effect is very important to mankind...
March 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28320092/inhibition-of-pi3k-akt-mtor-signaling-pathway-promotes-autophagy-of-articular-chondrocytes-and-attenuates-inflammatory-response-in-rats-with-osteoarthritis
#2
Jian-Feng Xue, Zhong-Min Shi, Jian Zou, Xiao-Lin Li
OBJECTIVE: This study aims to explore the relationship between PI3K/AKT/mTOR signaling pathway and autophagy of articular chondrocytes in rats with osteoarthritis (OA). METHODS: Rat articular chondrocytes were isolated and cultured, and then induced by protein inhibitors of PI3K/AKT/mTOR signaling pathway. Chondrocytes were assigned into blank group, IL-1β induction group (IL-1β group), PI3K inhibitor+IL-1β induction group (PI3Ki+IL-1β group), AKT inhibitor+IL-1β induction group (AKTi+IL-1β group) and mTOR inhibitor+IL-1β induction group (mTORi+IL-1β group)...
March 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28319901/a-novel-microbial-fuel-cell-sensor-with-biocathode-sensing-element
#3
Yong Jiang, Peng Liang, Panpan Liu, Donglin Wang, Bo Miao, Xia Huang
The traditional microbial fuel cell (MFC) sensor with bioanode as sensing element delivers limited sensitivity to toxicity monitoring, restricted application to only anaerobic and organic rich water body, and increased potential fault warning to the combined shock of organic matter/toxicity. In this study, the biocathode for oxygen reduction reaction was employed for the first time as the sensing element in MFC sensor for toxicity monitoring. The results shown that the sensitivity of MFC sensor with biocathode sensing element (7...
March 2, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28319888/heterogeneous-reaction-of-peroxyacetyl-nitrate-pan-on-soot
#4
Ximeng Zhao, Tianyu Gao, Jianbo Zhang
The interaction between photochemical oxidants and aerosol particles has been examined in previous atmospheric pollution studies. The heterogeneous reaction can affect the concentration of gases and free radicals, as well as the morphology and properties of particles. In this report, the interaction between the photochemical oxidant peroxyacetyl nitrate (PAN) and soot particles was investigated using a flow tube system. We used real-time online monitoring equipment to track changes in PAN concentrations. Substances on the soot surface were detected using ion chromatography (IC), x-ray photoelectron spectroscopy (XPS), and other surface analysis methods...
March 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28319777/analysis-of-the-effect-of-temperature-and-reaction-time-on-yields-compositions-and-oil-quality-in-catalytic-and-non-catalytic-lignin-solvolysis-in-a-formic-acid-water-media-using-experimental-design
#5
Mikel Oregui Bengoechea, Nemanja Miletíc, Mari H Vogt, Pedro L Arias, Tanja Barth
The catalytic solvolysis of Norway spruce (Picea abies L.) lignin in a formic acid/water media was explored at different temperatures and reaction times (283-397°C and 21-700min, respectively). Non-catalyzed experiments were compared with the effect of three different type of bifunctional catalysts (Pd/Al2O3, Rh/Al2O3 and Ru/Al2O3) and a solid Lewis acid (γ-Al2O3). We demonstrated that surface response methodology (RSM) and principal component analysis (PCA) were an adequate tool to: (i) evaluate the effect of the catalysts, temperature and reaction time in the oil yield, oil quality (H/C and O/C ratios, and Mw) and composition of the oil, (ii) establish the differences and/or similarities between the three bifunctional catalyst and (iii) to determine the role of the noble metal and the alumina support in the reaction system...
March 1, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28319739/mechanism-and-kinetics-of-halogenated-compound-removal-by-metallic-iron-transport-in-solution-diffusion-and-reduction-within-corrosion-films
#6
Shun Tang, Xiao-Mao Wang, Shi-Ting Liu, Hong-Wei Yang, Yuefeng F Xie, Xiao-Yi Yang
A detailed kinetic model comprised of mass transport (ktra), pore diffusion (kdif), adsorption and reduction reaction (krea), was developed to quantitatively evaluate the effect of corrosion films on the removal rate (kobs) of halogenated compounds by metallic iron. Different corrosion conditions were controlled by adjusting the iron aging time (0 or 1 yr) and dissolved oxygen concentration (0-7.09 mg/L DO). The kobs values for bromate, mono-, di- and tri-chloroacetic acids (BrO3(-), MCAA, DCAA and TCAA) were 0...
March 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28319643/grooved-glaucoma-drainage-devices-that-continuously-deliver-cyclosporine-a-decrease-postsurgical-scar-formation-in-rabbit-eyes
#7
Zhaoxing Dai, Xiaobo Yu, Jianguo Sun, Xinghuai Sun
Purpose: To study the functional outcomes of filtration surgery by implanting improved glaucoma drainage devices (GDDs) comprising surface grooves and a composite coating of cyclosporine A (CsA) and PLGA in experimental rabbit eyes. Methods: Improved GDDs were designed and prepared by modifying normal GDD with surface grooves and a CsA-PLGA composite coating. Normal GDDs, grooved GDDs (G-GDDs), and G-GDDs with a CsA-PLGA composite coating (CsA@G-GDD) were implanted into 18 rabbit eyes (six eyes per group)...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28319456/reactogenicity-of-cervarix-and-gardasil-human-papillomavirus-hpv-vaccines-in-a-randomized-single-blind-trial-in-healthy-uk-adolescent-females
#8
Tao Haskins-Coulter, Jo Southern, Nick Andrews, Elizabeth Miller
One hundred and ninety eight females aged 12-15 y were enrolled in an observer-blinded randomized trial to assess the immunogenicity and reactogenicity of the tetravalent HPV vaccine Gardasil® (group 2), in comparison to the bivalent HPV vaccine, Cervarix® (group 1), which was routinely offered in the national vaccination schedule at the time. Participants were blinded to treatment group until all 3 vaccinations had been given, while laboratory staff were masked during testing. For the majority of local and general reactions, recipients of both vaccines reported comparable frequencies...
March 20, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28319399/monitoring-photochemical-reactions-using-marangoni-flows
#9
Joost Muller, Hubertus M J M Wedershoven, Anton A Darhuber
We evaluated the sensitivity and time-resolution of a technique for photochemical reaction monitoring based on interferometric detection of the deformation of liquid films. The reaction products change the local surface tension and induce a Marangoni flow in the liquid film. As a model system, we consider the irradiation of the aliphatic hydrocarbon squalane with broadband deep-UV light. We developed a numerical model that quantitatively reproduces the flow patterns observed in the experiments. Moreover, we present self-similarity solutions that elucidate the mechanisms governing different stages of the dynamics and their parametric dependence...
March 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28319382/time-resolved-spectroscopic-investigation-of-charge-trapping-in-carbon-nitrides-photocatalysts-for-hydrogen-generation
#10
Robert Godin, Yiou Wang, Martijn A Zwijnenburg, Junwang Tang, James R Durrant
Carbon nitride (g-C3N4) as a benchmark polymer photocatalyst is attracting significant research interest because of its visible light photocatalytic performance combined with good stability and facile synthesis. However, little is known about the fundamental photophysical processes of g-C3N4, which are key to explain and promote photoactivity. Using time-resolved absorption and photoluminescence spectroscopies, we have investigated the photophysics of a series of carbon nitrides on timescales ranging from femtoseconds to seconds...
March 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28319332/merging-distal-alkynyl-migration-and-photoredox-catalysis-for-radical-trifluoromethylative-alkynylation-of-unactivated-olefins
#11
Yan Xu, Zhen Wu, Jingxing Jiang, Zhuofeng Ke, Chen Zhu
Disclosed herein is a novel, redox-neutral protocol for the visible-light-induced radical alkynylation of unactivated olefins. The intramolecular migration of an alkynyl group, by cleaving an inert C-C σ bond, is realized for the first time. A wide range of synthetically useful trifluoroethylated linear alkynes are readily obtained under mild reaction conditions.
March 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28319306/microrna-802-plays-a-tumour-suppressive-role-in-tongue-squamous-cell-carcinoma-through-directly-targeting-map2k4
#12
Xiaozhen Wu, Zuode Gong, Lanying Sun, Long Ma, Qibao Wang
OBJECTIVES: Tongue squamous cell carcinoma (TSCC) is the most common oral tumours. MicroRNAs play crucial roles in many cell processes including cell viability, development, apoptosis, migration and invasion. The role of miR-802 in the TSCC is still unknown. MATERIALS AND METHODS: The miR-802 expression in TSCC tissues and cell lines was determined by quantitative real-time polymerase chain reaction. CCK-8 assay was performed to measure the cell viability, while the cell invasion assay was used to determine the cell invasion...
March 20, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28319223/kinetics-and-heterogeneity-of-energy-transfer-from-light-harvesting-complex-ii-to-photosystem-i-in-the-supercomplex-isolated-from-arabidopsis
#13
Stefano Santabarbara, Tania Tibiletti, William Remelli, Stefano Caffarri
State transitions are a phenomenon that maintains the excitation balance between photosystem II (PSII) and photosystem I (PSI-LHCI) by controlling their relative absorption cross-sections. Under light conditions exciting PSII preferentially, a trimeric LHCII antenna moves from PSII to PSI-LHCI to form the PSI-LHCI-LHCII supercomplex. In this work, the excited state dynamics in the PSI-LHCI and PSI-LHCI-LHCII supercomplexes isolated from Arabidopsis have been investigated by picosecond time-resolved fluorescence spectroscopy...
March 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28319204/responses-to-others-pain-in-adults-with-autistic-traits-the-influence-of-gender-and-stimuli-modality
#14
Jing Meng, Zuoshan Li, Lin Shen
Individuals with autism-spectrum disorder (ASD) exhibit impairments in response to others' pain. Evidence suggests that features of autism are not restricted to individuals with ASD, and that autistic traits vary throughout the general population. To investigate the association between autistic traits and the responses to others' pain in typically developing adults, we employed the Autism-Spectrum Quotient (AQ) to quantify autistic traits in a group of 1670 healthy adults and explored whether 60 participants (30 males and 30 females) with 10% highest AQ scores (High-AQ) would exhibit difficulties in the responses to others' pain relative to 60 participants (30 males and 30 females) with 10% lowest AQ scores (Low-AQ)...
2017: PloS One
https://www.readbyqxmd.com/read/28319036/n-doped-nanoporous-co3o4-nanosheets-with-oxygen-vacancies-as-oxygen-evolving-electrocatalysts
#15
Lei Xu, Zhimin Wang, Jialu Wang, Zhaohui Xiao, Xiaobing Huang, Zhigang Liu, Shuangyin Wang
Developing highly active electrocatalysts for the oxygen evolution reaction (OER) with a high surface area, high catalytic activity, low cost and high conductivity is a big challenge for various energy technologies. Herein, for the first time, we realized the simultaneous nitrogen doping and etching of Co3O4 nanosheets to produce N-doped nanoporous Co3O4 nanosheets with oxygen vacancies by N2 plasma. The increase in active sites in N-doped Co3O4 nanosheets and improved electronic conductivity with N doping and oxygen vacancies results in excellent electrocatalytic activity for the OER...
March 20, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28318702/antibiotic-associated-diarrhea-clinical-characteristics-and-the-presence-of-clostridium-difficile
#16
A Rodríguez-Varón, O M Muñoz, J Pulido-Arenas, S B Amado, M Tobón-Trujillo
INTRODUCTION AND AIMS: Evidence in Colombia and Latin America has been insufficient for establishing the clinical characteristics of patients with antibiotic-associated diarrhea (AAD). The present study attempts to describe the clinical characteristics of patients with AAD and to determine the presence of Clostridium difficile, utilizing the polymerase chain reaction (PCR) technique. MATERIALS AND METHODS: Forty-three patients with AAD, managed at the Hospital Universitario San Ignacio in Bogota, Colombia, were evaluated...
March 15, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/28318608/multi-center-evaluation-of-one-commercial-and-12-in-house-real-time-pcr-assays-for-detection-of-mycoplasma-pneumoniae
#17
Roger Dumke, Alvaro J Benitez, Victoria Chalker, Karolina Gullsby, Birgit Henrich, Carlos Hidalgo-Grass, Theo Hoogenboezem, Darja Kese, Katherine Loens, Jolanda Maaskant, Ayelet Michael-Gayego, Allon E Moses, Ran Nir-Paz, Suzan D Pas, Sabine Pereyre, Randi F Petersen, Meike Rosenblatt, Annemarie M C van Rossum, Søren A Uldum, Wendy W J Unger, Dominique Ursi, Jonas M Winchell, Cecile Bebear
Detection of Mycoplasma pneumoniae by real-time PCR is not yet standardized across laboratories. We have implemented a standardization protocol to compare the performance of thirteen commercial and in-house approaches. Despite differences on threshold values of samples, all assays were able to detect at least 20M. pneumoniae genomes per reaction.
March 8, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28318450/repeated-sprints-in-fasted-state-impair-reaction-time-performance
#18
Anissa Cherif, Romain Meeusen, Abdulaziz Farooq, Walid Briki, Mohamed Amine Fenneni, Karim Chamari, Bart Roelands
OBJECTIVE: The aim of this study was to assess the effects of 3-day Islamic intermittent fasting (3d-IF) on cognitive performance and serum levels of neurotrophic factors (brain-derived neurotrophic factor [BDNF] and vascular endothelial growth factor [VEGF]) before and after repeated sprints. METHODS: Twenty-one physically active male Muslims (29.8 ± 5.9 years, exercising 4 ± 1.5 times/week) were randomly assigned to one of 2 experimental sessions: the control or nonfasting session (CS) or the fasting session (FS)...
March 20, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28318412/effects-of-lithium-and-2-4-dichlorophenol-on-zebrafish-circadian-rhythm-disorder-and-molecular-effects
#19
Bo Xiao, Li-Qiang Cui, Cheng Ding, Han Wang
The aim of this study was to investigate lithium and 2,4-dichlorophenol (2,4-DCP)-induced circadian rhythm disorder and their genome-wide effects in zebrafish. Zebrafish larvae were exposed to 250 ppm LiCl (n = 40) or 20 ppm 2,4-DCP. RNA was subsequently extracted and determined quantitatively. The mRNA levels of circadian clock-related genes, including clock1a, bmal1b, per2, and per1b, were determined. Microarray datasets were generated and the differentially expressed genes (DEGs) were identified. The mRNA levels of some upregulated and downregulated DEGs were examined by quantitative real-time polymerase chain reaction (RT-PCR)...
March 20, 2017: Zebrafish
https://www.readbyqxmd.com/read/28318244/variability-of-zinc-oxide-dissolution-rates
#20
Monika Michaelis, Cornelius Fischer, Lucio Colombi Ciacchi, Andreas Luttge
Zinc oxide (ZnO) is of widespread use for numerous applications including many in the cosmetic industry. Thus, ZnO particles have a high potential to enter the environment. ZnO may be harmful because of the release of cytotoxic Zn2+ ions during dissolution reactions. Here, we analyze the dissolution kinetics of the polar zinc terminated (000-1) and the non-polar (10-10) crystal surfaces in ultrapure water to examine the crystal defect impact to dissolution. By using a complementary approach of atomic force microscopy (AFM) and vertical scanning interferometry (VSI), we quantify the reaction rate difference between the crystal faces, the overall range of rate variability, and the rate components that combine to an overall rate...
March 20, 2017: Environmental Science & Technology
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