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https://www.readbyqxmd.com/read/29166707/-establishment-of-myocardial-targeted-nanoparticles-and-preliminary-evaluation-of-its-effects-on-prevention-and-treatment-of-myocardial-injury
#1
Y Y Liu, C Wang, P F Luo, Z F Xia
Objective: To establish 3-{4-[2-hydroxyl-(1-methylethylamino) propoxy] phenyl} propionic acid cetylesters (PAC) modified nanoparticles, and preliminarily explore its cardiomyocyte-targeting function and protection effects on myocardium. Methods: (1) HL-1 myocardial cells were divided into cyanidin-3 (Cy3) marked non-targeted small interference RNA (Cy3-siNC) group and Cy3 marked small interference RNA designed for the nuclear factor kappa B (NF-κB)-p65 gene (Cy3-si435) group according to the random number table, with 3 wells in each group...
November 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29166559/dynamic-nature-of-thiolate-monolayer-in-au25-sr-18-nanoclusters
#2
Giovanni Salassa, Annelies Sels, Fabrizio Mancin, Thomas Burgi
Thiolate monolayer, protecting gold nanocluster, is the principal responsible of their chemical behavior and their interaction with the environment. Understanding the parameters that influence the sta-bility and reactivity of the monolayer will enable its precise and controlled functionalization. Here we present a protocol for the investigation of the monolayer reactivity in Au25(SR)18 based on MALDI mass spectrometry and NMR spectroscopy. Thiol ex-change reaction between cluster and thiol molecules has been inves-tigated showing how this reaction is affected by the thiol affinity for Au25...
November 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/29166170/highly-accurate-identification-of-cystic-precursor-lesions-of-pancreatic-cancer-through-targeted-mass-spectrometry-a-phase-iic-diagnostic-study
#3
Karolina S Jabbar, Liisa Arike, Caroline S Verbeke, Riadh Sadik, Gunnar C Hansson
Purpose Pancreatic cystic lesions are common incidental findings on imaging, but up to half may be forerunners of pancreatic cancer. Therefore, accurate differential diagnosis is crucial for correct patient management. Unfortunately, currently available diagnostic methods cannot robustly identify premalignant and malignant pancreatic cystic lesions. Methods Cyst fluid samples obtained by routine endoscopic ultrasound-guided aspiration were used for the analyses. In a cohort of 24 patients, eight biomarker candidates for malignant potential and high-grade dysplasia/cancer were identified by an explorative proteomic approach...
November 22, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29166118/photofragmentation-of-gas-phase-acetic-acid-and-acetamide-clusters-in-the-vacuum-ultraviolet-region
#4
Marta Berholts, Hanna Myllynen, Kuno Kooser, Eero Itälä, Sari Granroth, Helena Levola, Joakim Laksman, Shabnam Oghbaiee, Bart Oostenrijk, Ergo Nõmmiste, Edwin Kukk
Photofragmentation of gas-phase acetamide and acetic acid clusters produced by a supersonic expansion source has been studied using time-of-flight mass spectrometry and the partial ion yield (PIY) technique combined with tunable vacuum-ultraviolet synchrotron radiation. Appearance energies of the clusters and their fragments were experimentally determined from the PIY measurements. The effect of clusterization conditions on the formation and fragmentation of acetic acid clusters was investigated. Ab initio quantum mechanical calculations were performed on both samples' dimers to find their neutral and ionized geometries as well as proton transfer energy barriers leading to the optimal geometries...
November 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29166115/resonant-electron-attachment-to-mixed-hydrogen-oxygen-and-deuterium-oxygen-clusters
#5
Michael Renzler, Lorenz Kranabetter, Erik Barwa, Lukas Grubwieser, Paul Scheier, Andrew M Ellis
Low energy electron attachment to mixed (H2)x/(O2)y clusters and their deuterated analogs has been investigated for the first time. These experiments were carried out using liquid helium nanodroplets to form the clusters, and the effect of the added electron was then monitored via mass spectrometry. There are some important differences between electron attachment to the pure clusters and to the mixed clusters. A particularly notable feature is the formation of HO2(-) and H2O(-) ions from an electron-induced chemical reaction between the two dopants...
November 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29166105/electrode-reactions-in-slowly-relaxing-media
#6
Dmitry V Matyushov, Marshall D Newton
Standard models of reaction kinetics in condensed materials rely on the Boltzmann-Gibbs distribution for the population of reactants at the top of the free energy barrier separating them from the products. While energy dissipation and quantum effects at the barrier top can potentially affect the transmission coefficient entering the rate pre-exponential factor, much stronger dynamical effects on the reaction barrier are caused by the breakdown of ergodicity for populating the reaction barrier (violation of the Boltzmann-Gibbs statistics)...
November 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29166059/qm-mm-nonadiabatic-dynamics-simulations-on-photoinduced-wolff-rearrangements-of-1-2-3-thiadiazole
#7
Xiang-Yang Liu, Ye-Guang Fang, Bin-Bin Xie, Wei-Hai Fang, Ganglong Cui
The photoinduced rearrangement reaction mechanism of 1,2,3-thiadiazole remains experimentally elusive. Two possible mechanisms have been proposed to date. The first is a stepwise mechanism via a thiocarbene intermediate; the second is an excited-state concerted rearrangement mechanism. Herein we have adopted both the electronic structure calculations and nonadiabatic dynamics simulations to study the photoinduced rearrangement reactions of 1,2,3-thiadiazole in the S2, S1, and S0 states in solution. On the basis of QM(CASPT2)/MM [quantum mechanics(complete active space self-consistent field second-order perturbation theory)/molecular mechanics] calculations, we have found that (1) the thiocarbene intermediate is not stable; thus, the stepwise mechanism should be unfavorable; (2) the excited-state decay from the S2 via S1 to S0 state is ultrafast and completed within ca...
June 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29166023/rhodium-catalyzed-synthesis-of-sulfur-ylides-via-in-situ-generated-iodonium-ylides
#8
Janakiram Vaitla, Kathrin H Hopmann, Annette Bayer
A convenient strategy for the synthesis of sulfur ylides via rhodium-catalyzed coupling of in situ generated iodonium ylides with sulfides or sulfoxides has been developed. A wide range of sulfur ylides were obtained in moderate to good yields from inexpensive sulfur compounds and active methylene compounds with a short reaction time (MW, 5-10 min) or 12-16 h at rt. Furthermore, these sulfoxonium ylides were used as novel acceptor/acceptor carbenes for N-H insertion reactions.
November 22, 2017: Organic Letters
https://www.readbyqxmd.com/read/29165918/micelle-assisted-electrodeposition-of-mesoporous-fe-pt-smooth-thin-films-onto-various-substrates-and-their-electrocatalytic-activity-towards-hydrogen-evolution-reaction
#9
Eloy Isarain-Chávez, Maria Dolors Baró, Carlos Alcantara, Salvador Pané, Jordi Sort, Eva Pellicer
Mesoporous Fe-Pt thin films are obtained by micelle-assisted electrodeposition onto metallic substrates with dissimilar activity (namely, gold, copper, and aluminum seed-layers evaporated on Si/Ti) under constant applied potential (E= -1.1 V vs. Ag/AgCl) and deposition time (600 s). The amphiphilic triblock copolymer Pluronic P-123 is used as a soft-template to guide the formation of mesopores. The occurrence of pores (ca. 7 nm in diameter) with narrow size distribution, regularly distributed over the surface, is observed in all cases...
November 22, 2017: ChemSusChem
https://www.readbyqxmd.com/read/29165856/saccharomyces-cerevisiae-hog1-map-kinase-pathway-is-activated-in-response-to-honokiol-exposure
#10
Lingmei Sun, Kai Liao
AIM: The goal of the study was to investigate the cellular tolerance mechanism in response to honokiol exposure. METHODS AND RESULTS: The broth microdilution method was employed to test the sensitivity of different Saccharomyces cerevisiae strains to honokiol. Intracellular levels of reactive oxygen species (ROS) were determined by DCFH-DA staining. The phosphorylation of Hog1 was evaluated by western blot analysis. The mRNA expressions of genes involved in the Ras-cyclic AMP (cAMP) pathway were analyzed by real-time reverse transcription polymerase chain reaction...
November 22, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29165707/inflammation-dynamics-after-praziquantel-treatment-of-schistosoma-haematobium-reflected-by-urinary-eosinophil-cationic-protein
#11
Chalotte Willemann Stecher, Hassan K M Fofana, Henry Madsen, Shona Wilson, Adama D Keita, Aly Landouré, Mamadou S Traoré, Birgitte J Vennervald, Claus M Reimert, Moussa Sacko
Background: This cohort study assessed urinary eosinophil cationic protein (ECP) as an indicator for urinary tract morbidity and inflammation indication related to single-dose or dual-dose praziquantel (PZQ) treatment. Methods: Urinary ECP was measured at baseline, 24 h and 9 weeks after treatment (baseline 305, follow-up 204 participants, ages 2-40 years). Results: ECP was significantly associated with the intensity of infection at baseline (p<0...
November 20, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29165657/rotavirus-vaccination-can-be-performed-without-viral-dissemination-in-the-neonatal-intensive-care-unit
#12
Hiroyuki Hiramatsu, Ryota Suzuki, Arisa Nagatani, Hiroko Boda, Masafumi Miyata, Fumihiko Hattori, Hiroki Miura, Ken Sugata, Shigeki Yamada, Satoshi Komoto, Koki Taniguchi, Masaru Ihira, Naoko Nishimura, Takao Ozaki, Tetsushi Yoshikawa
Background: This study was conducted to assess transmissibility of the vaccine strains after RV vaccination in a neonatal intensive care unit (NICU). Methods: Rotateq (RV5) or Rotarix (RV1) was administered to infants admitted to the NICU. Vaccinated infants (VIs, n=19) and unvaccinated infants (UVIs, n=49) whose beds were located in close proximity to the VIs were enrolled in this study. Fecal shedding of vaccine viruses and spreading of the vaccine strains within the NICU were examined using real-time reverse transcriptase polymerase chain reaction (RT-PCR)...
November 20, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29165576/timing-of-first-respiratory-virus-detections-in-infants-a-community-based-birth-cohort-study
#13
Mohinder Sarna, Robert S Ware, Stephen B Lambert, Theo P Sloots, Michael D Nissen, Keith Grimwood
Background: Determining timing of first virus detection episodes (fVDEs) for different respiratory viruses in infants identifies risk periods and informs preventive interventions, including vaccination. We describe the ages and nature of fVDEs in an infant birth cohort, and explore factors associated with increased odds of symptomatic fVDEs. Methods: The Observational Research in Childhood Infectious Diseases (ORChID) study is a community-based birth cohort describing acute respiratory infections in infants until their second birthday...
November 17, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29165483/ion-chemistry-at-elevated-ion-molecule-interaction-energies-in-a-selected-ion-flow-drift-tube-reactions-of-h3o-no-and-o2-with-saturated-aliphatic-ketones
#14
Anatolii Spesyvyi, David Smith, Patrik Španěl
The reactions of H3O(+), NO(+) and O2(+) ions with a homologous series of six aliphatic ketones, viz. acetone through 2-octanone, have been investigated in a helium-buffered selected ion flow-drift tube, SIFDT, in order to reveal their dependencies on ion-molecule interaction energies, Er, and to gain insight into their mechanisms. The ultimate motivation is to allow analysis and absolute quantification of trace amounts of ketones and other volatile organic compounds in air using selected ion flow-drift tube mass spectrometry, SIFDT-MS...
November 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29165443/a-magnetic-nanoparticle-supported-n-heterocyclic-carbene-palladacycle-an-efficient-and-recyclable-solid-molecular-catalyst-for-suzuki-miyaura-cross-coupling-of-9-chloroacridine
#15
Qinyue Deng, Yajing Shen, Haibo Zhu, Tao Tu
A robust magnetic nanoparticle-supported N-heterocyclic carbene-palladacycle has been readily synthesized by directly anchoring the structural defined acenaphthoimidazolylidene palladacycle with a long tail on magnetic nanoparticles (MNPs), and functioned as a solid molecular catalyst and exhibited extremely high catalytic activity towards the challenging Suzuki-Miyaura cross-coupling reactions between less-studied heterocyclic 9-chloroacridine and diverse boronic acids. Remarkably, the catalyst could be used 5 times without obvious loss of activity highlighting the efficiency of our strategy of immobilization of previledged catalysts...
November 22, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29165430/subcutaneous-administration-of-infliximab-attenuated-silica-induced-lung-fibrosis
#16
Hua Zhang, Jun-Na Sui, Lei Gao, Jian Guo
OBJECTIVES: To investigate the influence of the anti-tumor necrosis factor-α infliximab (IFX) in the case of rats with silicosis. MATERIAL AND METHODS: Forty-eight Wistar rats were randomly divided into 3 groups. The study group (N = 16) - silicosis was induced by intratracheal instillation of 50 mg silica on day 1, and IFX was subcutaneously administered at a dose of 15 mg/kg of body weight from day 2 to day 6, the vehicle group (N = 16) - silica used as the study group but without IFX, the sham group (N = 16) - 1 ml of saline was intratracheal-used...
November 21, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/29165380/direct-modification-of-microcrystalline-cellulose-with-ethylenediamine-for-use-as-adsorbent-for-removal-amitriptyline-drug-from-environment
#17
Roosevelt D S Bezerra, Régis C Leal, Mateus S da Silva, Alan I S Morais, Thiago H C Marques, Josy A Osajima, Andréia B Meneguin, Hernane da S Barud, Edson C da Silva Filho
Cellulose derivatives have been widely used as adsorbents for the removal of micropollutants such as drugs, dyes, and metals, due to their abundance, low cost and non-contaminating nature. In this context, several studies have been performed searching for new adsorbents (cellulose derivatives) efficient at contaminant removal from aqueous solutions. Thus, a new adsorbent was synthesized by chemical modification of cellulose with ethylenediamine in the absence of solvent and applied to the adsorption of amitriptyline (AMI) in aqueous solution...
November 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29165327/effects-of-dl-3-n-butylphthalide-on-cerebral-ischemia-infarction-in-rat-model-by-mass-spectrometry-imaging
#18
Run-Zhe Liu, Chao-Xin Fan, Zhi-Lin Zhang, Xin Zhao, Yi Sun, Hui-Hui Liu, Zong-Xiu Nie, Xiao-Ping Pu
Dl-3-n-butylphthalide (NBP) is a drug that is used in the treatment of ischaemic stroke. However, to the best of our knowledge, there are no systematic studies investigating the effects of dl-3-n-butylphtalide on the brain metabolism of small molecules. In this study, we first investigated the effects of dl-3-n-butylphthalide on the spatial distribution of small molecules in the brains of rats with permanent middle cerebral artery occlusion (pMCAO) using matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF-MS) imaging...
November 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29165231/sequence-optimized-real-time-reverse-transcription-polymerase-chain-reaction-assay-for-detection-of-crimean-congo-hemorrhagic-fever-virus
#19
Jeffrey W Koehler, Korey L Delp, Adrienne T Hall, Scott P Olschner, Brian J Kearney, Aura R Garrison, Louis A Altamura, Cynthia A Rossi, Timothy D Minogue
Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus of the genus Nairovirus within the family Bunyaviridae. Infection can result in general myalgia, fever, and headache with some patients developing hemorrhagic fever with mortality rates ranging from 5% to 30%. CCHFV has a wide geographic range that includes Africa, Asia, the Middle East, and Europe with nucleotide sequence variation approaching 20% across the three negative-sense RNA genome segments. While phylogenetic clustering generally aligns with geographic origin of individual strains, distribution can be wide due to tick/CCHFV dispersion via migrating birds...
November 20, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29165116/circular-rna-profiles-in-mouse-lung-tissue-induced-by-radon
#20
Weiwei Pei, Lijing Tao, Leshuai W Zhang, Shuyu Zhang, Jianping Cao, Yang Jiao, Jian Tong, Jihua Nie
BACKGROUND: Radon is a known human lung carcinogen, whose underlying carcinogenic mechanism remains unclear. Recently, circular RNA (circRNA), a class of endogenous non-protein coding RNAs that contain a circular loop, was found to exhibit multiple biological effects. In this study, circRNA profiles in mouse lung tissues between control and radon exposure were analyzed. METHODS: Six mice were exposed to radon at concentration of 100,000 Bq/m(3), 12 h/d, for up to cumulative doses of 60 working level months (WLM)...
April 7, 2017: Environmental Health and Preventive Medicine
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