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https://www.readbyqxmd.com/read/28346039/comparison-between-urinalysis-results-and-self-reported-heroin-use-among-patients-undergoing-methadone-maintenance-treatment-in-china
#1
Li Li, Li-Jung Liang, Chunqing Lin, Nan Feng, Zunyou Wu
BACKGROUND: The validity and concordance of two main measures of drug use behavior, self-report and urinalysis, has long been discussed. More understanding is needed about the underlying factors associated with discordance between these two methods. OBJECTIVES: Describe the pattern and associated factors of discordance between self-reported heroin use and the urinalysis results of opiate use among methadone maintenance therapy (MMT) patients in China. METHODS: A total of 2,448 MMT patients from 68 clinics in five provinces of China participated in a survey, which collected information on demographics, drug use and MMT-related factors, depressive symptoms, and drug avoidance self-efficacy...
March 27, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28343650/-surveillance-system-on-drug-abuse-interest-of-the-french-national-oppidum-program-of-french-addictovigilance-network
#2
Elisabeth Frauger, Liselotte Pochard, Quentin Boucherie, Adeline Giocanti, Cécile Chevallier, Amélie Daveluy, Valérie Gibaja, Anne-Sylvie Caous, Céline Eiden, Nicolas Authier, Reynald Le Boisselier, Marylène Guerlais, Émilie Jouanjus, Marion Lepelley, Véronique Pizzoglio, Stéphanie Pain, Nathalie Richard, Joëlle Micallef
It is important to assess drug abuse liability in 'real life' using different surveillance systems. OPPIDUM ('Observation of illegal drugs and misuse of psychotropic medications') surveillance system anonymously collects information on drug abuse and dependence observed in patients recruited in specialized care centers dedicated to drug dependence. The aim of this article is to demonstrate the utility of OPPIDUM system using 2015 data. OPPIDUM is a cross-sectional survey repeated each year since 1995. In 2015, 5003 patients described the modality of use of 10,159 psychoactive drugs...
February 22, 2017: Thérapie
https://www.readbyqxmd.com/read/28343423/management-of-precipitated-opiate-withdrawal-syndrome-induced-by-nalmefene-mistakenly-prescribed-in-opiate-dependent-patients-a-review-for-clinicians
#3
Nicolas Franchitto, Benedicte Jullian, Juliette Salles, Fanny Pelissier, Benjamin Rolland
Nalmefene, a long-acting µ-opioid antagonist approved to treat alcohol use disorder, is occasionally mistakenly prescribed to opiate-dependent or opioid-treated patients. We review recent literature on drug-drug interactions between nalmefene and opioids that lead to precipitated opioid withdrawal, and focus on its management and planning for care at discharge. Areas covered: This article provides a brief and comprehensive review of management of precipitated opioid withdrawal syndrome when nalmefene is associated with an opioid, whether misused or legally prescribed...
March 27, 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28339390/stability-of-fentanyl-citrate-in-polyolefin-bags
#4
Ronald F Donnelly
Fentanyl is used to manage pain because it is a potent lipophilic opiate agonist. The stability of fentanyl in polyolefin bags when diluted to either 10 µg/mL or 50 µg/mL with sodium chloride 0.9% has not been studied. The chemical stability of fentanyl 50 µg/mL packaged in polyvinyl chloride bags has been studied, however, the stability in polyolefin bags is lacking. Polyolefin bags were aseptically filled with either 10-µg/mL or 50-µg/mL fentanyl solution. Containers were then stored at either 5°C and protected from light or 22°C and exposed to light for 93 days...
November 2016: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28333316/convergent-balancing-selection-on-the-mu-opioid-receptor-in-primates
#5
Carolyn G Sweeney, Juliette M Rando, Helen N Panas, Gregory M Miller, Donna M Platt, Eric J Vallender
The mu opioid receptor is involved in many natural processes including stress response, pleasure, and pain. Mutations in the gene also have been associated with opiate and alcohol addictions as well as with responsivity to medication targeting these disorders. Two common and mutually exclusive polymorphisms have been identified in humans, A118G (N40D), found commonly in non-African populations, and C17T (V6A), found almost exclusively in African populations. While A118G has been studied extensively for associations and in functional assays, C17T is much less well understood...
March 15, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28325819/new-connections-getting-the-good-without-the-bad-opiate-edition
#6
Wei Wong
Researchers identify strategies to limit the adverse effects and liabilities of opioid receptor-targeting drugs.
March 21, 2017: Science Signaling
https://www.readbyqxmd.com/read/28324199/high-hiv-prevalence-and-risk-among-male-clients-of-female-sex-workers-in-hanoi-and-ho-chi-minh-city-vietnam
#7
Patrick Nadol, Tran Vu Hoang, Linh-Vi Le, Tuan Anh Nguyen, John Kaldor, Matthew Law
In Vietnam's concentrated HIV epidemic, female sex workers (FSWs) are at increased risk for acquiring and transmitting HIV, largely through their male clients. A high proportion of males in Vietnam report being clients of FSWs. Studying HIV-related risk factors and prevalence among male clients is important, particularly given the potential for male clients to be a 'bridge' of HIV transmission to the more general population or to sex workers. Time-location sampling was used to identify FSW in Hanoi and Ho Chi Minh City, Vietnam's largest cities, in 2013-2014...
March 21, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28323538/relationships-between-a-dissociative-subtype-of-ptsd-and-clinical-characteristics-in-patients-with-substance-use-disorders
#8
Michaela Mergler, Martin Driessen, Ursula Havemann-Reinecke, Dirk Wedekind, Christel Lüdecke, Martin Ohlmeier, Claudia Chodzinski, Sybille Teunißen, Steffen Weirich, Detlef Schläfke, Walter Renner, Ingo Schäfer, Gertrud Koesters, Christian Dette, Olaf Reis, Elisabeth H Sylvester, Martin Hoppe, Markus Stuppe, Thomas Broese, Udo Schneider, Christina Pletke
The increasing support for a dissociative subtype of post-traumatic stress disorder (PTSD-D) has led to its inclusion in DSM-5. We examined relationships between PTSD-D and relevant variables in patients with substance use disorders (SUD). The sample comprised N = 459 patients with SUD. The International Diagnostic Checklist and the Posttraumatic Diagnostic Scale were used to diagnose PTSD. In addition, participants completed the Childhood Trauma Questionnaire and the Dissociative Experiences Scale. The course of SUD was assessed by means of the European Addiction Severity Index...
March 21, 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/28320406/the-acceptability-and-feasibility-of-a-brief-psychosocial-intervention-to-reduce-blood-borne-virus-risk-behaviours-among-people-who-inject-drugs-a-randomised-control-feasibility-trial-of-a-psychosocial-intervention-the-protect-study-versus-treatment-as-usual
#9
Gail Gilchrist, Davina Swan, April Shaw, Ada Keding, Sarah Towers, Noel Craine, Alison Munro, Elizabeth Hughes, Steve Parrott, John Strang, Avril Taylor, Judith Watson
BACKGROUND: While opiate substitution therapy and injecting equipment provision (IEP) have reduced blood-borne viruses (BBV) among people who inject drugs (PWID), some PWID continue to share injecting equipment and acquire BBV. Psychosocial interventions that address risk behaviours could reduce BBV transmission among PWID. METHODS: A pragmatic, two-armed randomised controlled, open feasibility study of PWID attending drug treatment or IEP in four UK regions. Ninety-nine PWID were randomly allocated to receive a three-session manualised psychosocial group intervention and BBV transmission information booklet plus treatment as usual (TAU) (n = 52) or information booklet plus TAU (n = 47)...
March 21, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28319754/association-between-harm-reduction-intervention-uptake-and-skin-and-soft-tissue-infections-among-people-who-inject-drugs
#10
Karen Dunleavy, Alison Munro, Kirsty Roy, Sharon Hutchinson, Norah Palmateer, Tony Knox, David Goldberg, Avril Taylor
BACKGROUND: Bacterial skin and soft tissue infections (SSTIs) are a health issue for people who inject drugs (PWID). There is a lack of evidence on the associations between harm reduction (HR) uptake and SSTIs. This paper examines the associations between the uptake of injecting equipment (IE) and opiate substitution treatment (OST) on SSTIs among PWID, and the injecting behaviours associated with having had an SSTI. This is the first large-scale, national study to examine the association between IE uptake and SSTIs...
March 6, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28319025/is-robot-assisted-laparoscopic-bilateral-extravesical-ureteral-reimplantation-associated-with-greater-morbidity-than-unilateral-surgery-a-comparative-analysis
#11
Arun K Srinivasan, Daniel Maass, Dhiren Shrivastava, Christopher J Long, Aseem R Shukla
INTRODUCTION: Voiding dysfunction after bilateral extravesical ureteral reimplantation for vesicoureteral reflux has long remained a concern. Robotic approach with improved visualization that enables focused and minimal dissection may help with this concern. OBJECTIVES: To compare postoperative outcomes after bilateral robot-assisted laparoscopic ureteral reimplantation to unilateral robot-assisted laparoscopic ureteral reimplantation. STUDY DESIGN: This was a retrospective study using data abstracted from an institutional review board-approved registry prospectively maintained at our institution since 2012...
March 6, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28318209/end-of-life-care-managing-common-symptoms
#12
REVIEW
Ross H Albert
Physicians should be proficient at managing symptoms as patients progress through the dying process. When possible, proactive regimens that prevent symptoms should be used, because it is generally easier to prevent than to treat an acute symptom. As swallowing function diminishes, medications are typically administered sublingually, transdermally, or via rectal suppository. Opiates are the medication of choice for the control of pain and dyspnea, which are common symptoms in the dying process. Delirium and agitation may be caused by reversible etiologies, which should be identified and treated when feasible...
March 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28317188/occupational-opiate-contact-dermatitis
#13
Sophie Colomb, Jean L Bourrain, Nathalie Bonardel, Anca Chiriac, Pascal Demoly
No abstract text is available yet for this article.
April 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28306680/anaesthesia-in-patients-with-liver-disease
#14
Malgorzata H Starczewska, Wint Mon, Peter Shirley
PURPOSE OF REVIEW: The purpose of this review is to summarize the most recent up to date research data and recommendations regarding anaesthetic management of patients with liver disease undergoing surgery. The incidence of chronic liver disease (CLD) continues to rise and perioperative mortality and morbidity remains unacceptably high in this group. Meticulous preoperative assessment and carefully planned anaesthetic management are vital in improving outcomes in patients with liver disease undergoing surgery...
March 16, 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28306543/peripheral-levels-of-bdnf-and-opiate-use-disorder-literature-review-and-update
#15
Raul Felipe Palma-Álvarez, Elena Ros-Cucurull, Kristopher Amaro-Hosey, Laia Rodriguez-Cintas, Lara Grau-López, Margarida Corominas-Roso, Cristina Sánchez-Mora, Carlos Roncero
Several neurobiological factors are related to opiate-use disorder (OUD), and among them, neurotrophins have a relevant role. Brain-derived neurotrophic factor (BDNF) is a central neurotrophin involved in many neuronal processes, and it has been related to several psychiatric diseases and addictive disorders. BDNF can be measured in plasma and serum; its levels may reflect BDNF concentrations in the central nervous system (CNS) and, indirectly, CNS processes. Hence, peripheral BDNF could be a biomarker in clinical practice...
March 17, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28303899/the-behavioral-effects-of-the-antidepressant-tianeptine-require-the-mu-opioid-receptor
#16
Benjamin Adam Samuels, Katherine M Nautiyal, Andrew C Kruegel, Marjorie R Levinstein, Valerie M Magalong, Madalee M Gassaway, Steven G Grinnell, Jaena Han, Michael A Ansonoff, John E Pintar, Jonathan A Javitch, Dalibor Sames, René Hen
Depression is a debilitating chronic illness that affects around 350 million people worldwide. Current treatments, such as selective serotonin reuptake inhibitors (SSRIs), are not ideal because only a fraction of patients achieve remission. Tianeptine is an effective antidepressant with a previously unknown mechanism of action. We recently reported that tianeptine is a full agonist at the mu-opioid receptor (MOR). Here we demonstrate that the acute and chronic antidepressant-like behavioral effects of tianeptine in mice require MOR...
March 17, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28301858/anti-nerve-growth-factor-therapy-increases-spontaneous-day-night-activity-in-mice-with-orthopedic-surgery-induced-pain
#17
Lisa A Majuta, Jean-Marc G Guedon, Stefanie A T Mitchell, Michael H Ossipov, Patrick W Mantyh
Total knee arthroplasty (TKA) and total hip arthroplasty (THA) are 2 of the most common and successful surgical interventions to relieve osteoarthritis pain. Control of postoperative pain is critical for patients to fully participate in the required physical therapy which is the most influential factor in effective postoperative knee rehabilitation. Currently, opiates are a mainstay for managing postoperative orthopedic surgery pain including TKA or THA pain. Recently, issues including efficacy, dependence, overdose, and death from opiates have made clinicians and researchers more critical of use of opioids for treating nonmalignant skeletal pain...
April 2017: Pain
https://www.readbyqxmd.com/read/28291977/five-factor-model-personality-profiles-the-differences-between-alcohol-and-opiate-addiction-among-females
#18
Diana Raketic, Jasmina V Barisic, Snezana M Svetozarevic, Tatjana Gazibara, Darija Kisic Tepavcevic, Srdjan D Milovanovic
BACKGROUND: The prevalence of female alcohol and substance abusers has markedly increased. The main objective of this research was to explore personality profiles among females who had alcohol and opiate dependence. AIM: The aim of the study is to analyse if there is differences in personality profiles of females addicted to alcohol and opiates. We hypothesized that there might be significant differences in personality profiles among subgroups of women who present with alcohol and opiate use disorders...
March 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28288815/rf313-an-orally-bioavailable-neuropeptide-ff-receptor-antagonist-opposes-effects-of-rf-amide-related-peptide-3-and-opioid-induced-hyperalgesia-in-rodents
#19
Khadija Elhabazi, Jean-Paul Humbert, Isabelle Bertin, Raphaelle Quillet, Valérie Utard, Martine Schmitt, Jean-Jacques Bourguignon, Emilie Laboureyras, Meric Ben Boujema, Guy Simonnet, Caroline Ancel, Valérie Simonneaux, Massimiliano Beltramo, Bernard Bucher, Tania Sorg, Hamid Meziane, Elodie Schneider, Benoit Petit-Demoulière, Brigitte Ilien, Frédéric Bihel, Frédéric Simonin
Although opiates represent the most effective analgesics, their use in chronic treatments is associated with numerous side effects including the development of pain hypersensitivity and analgesic tolerance. We recently identified a novel orally active neuropeptide FF (NPFF) receptor antagonist, RF313, which efficiently prevents the development of fentanyl-induced hyperalgesia in rats. In this study, we investigated the properties of this compound into more details. We show that RF313 exhibited a pronounced selectivity for NPFF receptors, antagonist activity at NPFF1 receptor (NPFF1R) subtype both in vitro and in vivo and no major side effects when administered in mice up to 30 mg/kg...
March 10, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28287019/effect-of-prenatal-restraint-stress-and-morphine-co-administration-on-plasma-vasopressin-concentration-and-anxiety-behaviors-in-adult-rat-offspring
#20
Elnaz Nakhjiri, Ehsan Saboory, Shiva Roshan-Milani, Yousef Rasmi, Davod Khalafkhani
Stressful events and exposure to opiates during gestation have important effects on the later mental health of the offspring. Anxiety is among the most common mental disorders. The present study aimed to identify effects of prenatal restraint stress and morphine co-administration on plasma vasopressin concentration (PVC) and anxiety behaviors in rats. Pregnant rats were divided into four groups (n = 6, each): saline, morphine, stress+saline and stress+morphine treatment. The stress procedure consisted of restraint twice per day, two hours per session, for three consecutive days starting on day 15 of pregnancy...
March 12, 2017: Stress: the International Journal on the Biology of Stress
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