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Diabetic nerves

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https://www.readbyqxmd.com/read/28211272/effects-of-dimethyloxalylglycine-embedded-poly-%C3%AE%C2%B5-caprolactone-fiber-meshes-on-wound-healing-in-diabetic-rats
#1
Qiankun Zhang, Joung-Hwan Oh, Chan Ho Park, Jeong-Hwa Baek, Hyun-Mo Ryoo, Kyung Mi Woo
Impaired wound healing in diabetic patients is associated with altered inflammatory responses, poor angiogenesis, deficient extracellular matrix (ECM) component, and peripheral neuropathy. To develop a wound dressing that is capable of the controlled delivery of bioactive small molecules that can improve diabetic wound healing, dimethyloxalylglycine (DMOG)-embedded poly(ε-caprolactone) (PCL) fiber (PCLF/DMOG) meshes are fabricated by electrospinning, and the effects of the PCLF/DMOG meshes on wound healing in diabetic rats are evaluated...
February 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28203223/impaired-axonal-regeneration-in-diabetes-perspective-on-the-underlying-mechanism-from-in-vivo-and-in-vitro-experimental-studies
#2
REVIEW
Kazunori Sango, Hiroki Mizukami, Hidenori Horie, Soroku Yagihashi
Axonal regeneration after peripheral nerve injury is impaired in diabetes, but its precise mechanisms have not been elucidated. In this paper, we summarize the progress of research on altered axonal regeneration in animal models of diabetes and cultured nerve tissues exposed to hyperglycemia. Impaired nerve regeneration in animal diabetes can be attributed to dysfunction of neurons and Schwann cells, unfavorable stromal environment supportive of regenerating axons, and alterations of target tissues receptive to reinnervation...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28202943/arterial-pressure-lability-is-improved-by-sodium-glucose-cotransporter-2-inhibitor-in-streptozotocin-induced-diabetic-rats
#3
Tomoko Yoshikawa, Takuya Kishi, Keisuke Shinohara, Ko Takesue, Risa Shibata, Noriyuki Sonoda, Toyoshi Inoguchi, Kenji Sunagawa, Hiroyuki Tsutsui, Yoshitaka Hirooka
To prevent cardiovascular events in patients with diabetes mellitus (DM), it is essential to reduce arterial pressure (AP). Sodium-glucose cotransporter 2 inhibitor (SGLT2i) prevents cardiovascular events via the depressor response in patients with DM. In the present study, we examined whether SGLT2i ameliorates AP lability in DM rats. Ten-week-old male Sprague-Dawley rats were administered a single intravenous injection of streptozotocin (50 mg kg(-1)) and were divided into three groups treated with low-dose SGLT2i, vehicle (VEH) or subcutaneously implanted insulin pellets (SGLT2i, VEH and Insulin group, respectively) for 14 days...
February 16, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28202580/spinal-disinhibition-in-experimental-and-clinical-painful-diabetic-neuropathy
#4
Andrew G Marshall, Corinne Lee-Kubli, Shazli Azmi, Michael Zhang, Maryam Ferdousi, Teresa Mixcoatl-Zecuatl, Ioannis N Petropoulos, Georgios Ponirakis, Mark S Fineman, Hassan Fadavi, Katie Frizzi, Mitra Tavakoli, Maria Jeziorska, Corinne G Jolivalt, Andrew J M Boulton, Nathan Efron, Nigel A Calcutt, Rayaz A Malik
Impaired rate dependent depression (RDD) of the Hoffman-reflex is associated with reduced dorsal spinal cord potassium chloride co-transporter expression and impaired spinal GABAA receptor function, indicative of spinal inhibitory dysfunction. We have investigated the pathogenesis of impaired RDD in diabetic rodents exhibiting features of painful neuropathy and the translational potential of this marker of spinal inhibitory dysfunction in human painful diabetic neuropathy. Impaired RDD and allodynia were present in type 1 and type 2 diabetic rats but not in rats with type 1 diabetes receiving insulin supplementation that did not restore normoglycemia...
February 15, 2017: Diabetes
https://www.readbyqxmd.com/read/28202549/relationships-between-type-2-diabetes-neuropathy-and-microvascular-dysfunction-evidence-from-patients-with-cryptogenic-axonal-polyneuropathy
#5
Anna L Emanuel, Mariska D Nieuwenhoff, Erica S Klaassen, Ajay Verma, Mark H H Kramer, Rob Strijers, Alexander F J E Vrancken, Etto Eringa, Geert Jan Groeneveld, Erik H Serné
OBJECTIVE: This study investigated whether the relationship between neuropathy and microvascular dysfunction in patients with type 2 diabetes is independent of diabetes-related factors. For this purpose, we compared skin microvascular function in patients with type 2 diabetes with that of patients with cryptogenic axonal polyneuropathy (CAP), a polyneuropathy of unknown etiology. RESEARCH DESIGN AND METHODS: Cross-sectional information was collected from 16 healthy controls (HCs), 16 patients with CAP, 15 patients with type 2 diabetes with polyneuropathy (DPN), and 11 patients with type 2 diabetes without polyneuropathy...
February 15, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28193212/corticomedullary-mixed-tumour-resembling-a-small-adrenal-gland-involvement-of-cancer-stem-cells-case-report
#6
Lian Duan, Fang Fang, Wanlei Fu, Zhenqiang Fang, Hui Wang, Shicang Yu, Zili Tang, Zhenqi Liu, Hongting Zheng
BACKGROUND: Adrenal corticomedullary mixed tumours are very rare. Its mechanism is rarely reported. Here we report the first case of a corticomedullary mixed tumour resembling a "small adrenal gland" with distinct arrangement of the cortical and medullary layers. We further hypothesize regarding the tumorigenic mechanism of this tumour. CASE PRESENTATION: A 58-year man had been diagnosed with diabetes and hypertension for 3 years. His 24-h urine vanillylmandelic acid (VMA) levels were slightly elevated...
February 13, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28191500/insights-from-genetic-model-systems-of-retinal-degeneration-role-of-epsins-in-retinal-angiogenesis-and-vegfr2-signaling
#7
Yunzhou Dong, Xue Cai, Yong Wu, Yanjun Liu, Lin Deng, Hong Chen
The retina is a light sensitive tissue that contains specialized photoreceptor cells called rods and cones which process visual signals. These signals are relayed to the brain through interneurons and the fibers of the optic nerve. The retina is susceptible to a variety of degenerative diseases, including age-related macular degeneration (AMD), diabetic retinopathy (DR), retinitis pigmentosa (RP) and other inherited retinal degenerations. In order to reveal the mechanism underlying these diseases and to find methods for the prevention/treatment of retinal degeneration, animal models have been generated to mimic human eye diseases...
January 2017: Journal of Nature and Science
https://www.readbyqxmd.com/read/28191471/lipids-a-suitable-therapeutic-target-in-diabetic-neuropathy
#8
REVIEW
M C Perez-Matos, M C Morales-Alvarez, C O Mendivil
Diabetic polyneuropathy (DPN) encompasses multiple syndromes with a common pathogenesis. Glycemic control shows a limited correlation with DPN, arguing in favor of major involvement of other factors, one of which is alterations of lipid and lipoprotein metabolism. Consistent associations have been found between plasma triglycerides/remnant lipoproteins and the risk of DPN. Studies in cultured nerve tissue or in murine models of diabetes have unveiled mechanisms linking lipid metabolism to DPN. Deficient insulin action increases fatty acids flux to nerve cells, inducing mitochondrial dysfunction, anomalous protein kinase C signaling, and perturbations in the physicochemical properties of the plasma membrane...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28190392/pi3k-akt-pathway-a-potential-therapeutic-target-for-chronic-pain
#9
Shu-Ping Chen, Ya-Qun Zhou, Dai-Qiang Liu, Wen Zhang, Anne Manyande, Xue-Hai Guan, Yu-Ke Tian, Da-Wei Ye, Deeq Mohamed Omar
Chronic pain is among the most disabling and costly disorders, with prevalence ranging from 10% to 55%. However, current therapeutic strategies for chronic pain are unsatisfactory due to our poor understanding of its mechanisms. Thus, novel therapeutic targets need to be found in order to improve these patients' quality of life. PI3K and its downstream Akt are widely expressed in the spinal cord, particularly in the laminae I-IV of the dorsal horn, where nociceptive C and Aδ fibers of primary afferents principally terminate...
February 10, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28184326/does-endurance-training-compensate-for-neurotrophin-deficiency-following-diabetic-neuropathy
#10
Rasoul Eslami, Reza Gharakhanlou, Abdolreza Kazemi, Amir Bahador Dakhili, Ghazaleh Sorkhkamanzadeh, Ayob Sheikhy
BACKGROUND: A lack of neurotrophic support is believed to contribute to the development of diabetic neuropathy. On the other hand, neurotrophins have consistently been shown to increase in the central and peripheral nervous system following exercise, but the effects of exercise intervention on brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in diabetic neuropathy are not understood. OBJECTIVES: This experimental study was designed and carried out at the Tarbiat Modares university (TMU) in Tehran, Iran, to investigate the hypothesis that increased activity as endurance training can help to increase the endogenous expression of neurotrophins in diabetic rats...
October 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28182728/uncovering-sensory-axonal-dysfunction-in-asymptomatic-type-2-diabetic-neuropathy
#11
Jia-Ying Sung, Jowy Tani, Tsui-San Chang, Cindy Shin-Yi Lin
This study investigated sensory and motor nerve excitability properties to elucidate the development of diabetic neuropathy. A total of 109 type 2 diabetes patients were recruited, and 106 were analyzed. According to neuropathy severity, patients were categorized into G0, G1, and G2+3 groups using the total neuropathy score-reduced (TNSr). Patients in the G0 group were asymptomatic and had a TNSr score of 0. Sensory and motor nerve excitability data from diabetic patients were compared with data from 33 healthy controls...
2017: PloS One
https://www.readbyqxmd.com/read/28179636/association-of-urinary-nerve-growth-factor-levels-with-erectile-function-in-young-men-with-type-2-diabetes-mellitus
#12
C-C Wang, C-H Liao, H-T Liu, J-M Lin, H-C Kuo
We investigated urine nerve growth factor (NGF) levels and erectile dysfunction in diabetic men <45 years of age. Urinary NGF levels were measured in 72 diabetic men and 20 control subjects without lower urinary tract symptoms or erectile dysfunction. Participants were evaluated using the International Prostate Symptom Score, quality of life index, Overactive Bladder Symptom Score (OABSS), the five-item version of the International Index of Erectile Function questionnaire (IIEF-5), the patient perception of bladder condition questionnaire, measurement of flow rate and post-void residual urine volume...
February 9, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/28176937/an-integrated-perspective-on-diabetic-alcoholic-and-drug-induced-neuropathy-etiology-and-treatment-in-the-us
#13
REVIEW
Lily Zeng, Doungkamol Alongkronrusmee, Richard M van Rijn
Neuropathic pain (NeuP) is a syndrome that results from damaged nerves and/or aberrant regeneration. Common etiologies of neuropathy include chronic illnesses and medication use. Chronic disorders, such as diabetes and alcoholism, can cause neuronal injury and consequently NeuP. Certain medications with antineoplastic effects also carry an exquisitely high risk for neuropathy. These culprits are a few of many that are fueling the NeuP epidemic, which currently affects 7%-10% of the population. It has been estimated that approximately 10% and 7% of US adults carry a diagnosis of diabetes and alcohol disorder, respectively...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28156005/different-insulin-types-and-regimens-for-pregnant-women-with-pre-existing-diabetes
#14
REVIEW
Sinéad M O'Neill, Louise C Kenny, Ali S Khashan, Helen M West, Rebecca Md Smyth, Patricia M Kearney
BACKGROUND: Insulin requirements may change during pregnancy, and the optimal treatment for pre-existing diabetes is unclear. There are several insulin regimens (e.g. via syringe, pen) and types of insulin (e.g. fast-acting insulin, human insulin). OBJECTIVES: To assess the effects of different insulin types and different insulin regimens in pregnant women with pre-existing type 1 or type 2 diabetes. SEARCH METHODS: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (30 October 2016), ClinicalTrials...
February 3, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28149097/magnetic-resonance-imaging-findings-of-isolated-abducent-nerve-palsy-induced-by-vascular-compression-of-vertebrobasilar-dolichoectasia
#15
Hidetaka Arishima, Ken-Ichiro Kikuta
If the origin of isolated abducent nerve palsy cannot be found on neuroradiological examinations, diabetes mellitus is known as a probable cause; however, some cases show no potential causes of isolated abducent nerve palsy. Here, we report a 74-year-old male who suffered from diplopia due to isolated left abducent nerve palsy. Magnetic resonance angiography and fast imaging employing steady-state acquisition imaging clearly showed a dolichoectasic vertebrobasilar artery compressing the left abducent nerve upward and outward...
January 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28142165/-influence-of-luxury-foodstuffs-on-glaucoma
#16
K K Huber-van der Velden
The term "luxury foodstuffs" refers to foods which are not consumed because of their nutritional value. Classic modern luxury foodstuffs are alcohol, caffeine-containing drinks, cocoa, sugar and tobacco. The following review article examines some of these modern luxury foodstuffs in detail, as well as their influence on glaucoma. Thus, small quantities of alcohol lower high intraocular pressure and have a positive influence on the blood circulation of the optic nerve. In addition, red wine polyphenols exert vasoprotective effects...
January 31, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28138810/photobiostimulation-reverses-allodynia-and-peripheral-nerve-damage-in-streptozotocin-induced-type-1-diabetes
#17
Igor Rafael Correia Rocha, Adriano Polican Ciena, Alyne Santana Rosa, Daniel Oliveira Martins, Marucia Chacur
For better evaluation of the efficacy of low-level laser therapy in treating painful diabetic neuropathy and in protecting nerve fiber damage, we conducted a study with type 1 diabetic rats induced by streptozotocin. It is well known that diabetic peripheral neuropathy is the leading cause of pain in those individuals who suffer from diabetes. Despite the efficacy of insulin in controlling glucose level in blood, there is no effective treatment to prevent or reverse neuropathic damage for total pain relief...
January 30, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28138246/association-of-peripheral-neuropathy-with-sleep-related-breathing-disorders-in-myotonic-dystrophies
#18
Marta Banach, Jakub Antczak, Rafał Rola
BACKGROUND: Myotonic dystrophy (DM) type 1 and type 2 are inherited diseases characterized by myotonia and myopathy. Additional symptoms include, among others, peripheral neuropathy and sleep-related breathing disorders (SRBDs). There is growing evidence for a complex association between DM1 and DM2, which was described in patients with diabetes mellitus and in the general population. In this study, we investigated whether there is an association between peripheral neuropathy and SRBDs also in the population of patients with DM...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28134254/schwann-cell-interactions-with-axons-and-microvessels-in-diabetic-neuropathy
#19
REVIEW
Nádia P Gonçalves, Christian B Vægter, Henning Andersen, Leif Østergaard, Nigel A Calcutt, Troels S Jensen
The prevalence of diabetes worldwide is at pandemic levels, with the number of patients increasing by 5% annually. The most common complication of diabetes is peripheral neuropathy, which has a prevalence as high as 50% and is characterized by damage to neurons, Schwann cells and blood vessels within the nerve. The pathogenic mechanisms of diabetic neuropathy remain poorly understood, impeding the development of targeted therapies to treat nerve degeneration and its most disruptive consequences of sensory loss and neuropathic pain...
January 30, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28133612/tang-luo-ning-improves-mitochondrial-antioxidase-activity-in-dorsal-root-ganglia-of-diabetic-rats-a-proteomics-study
#20
Taojing Zhang, Yanbin Gao, Yanbin Gong, Hui Zhou, Peifeng Xie, Song Guan, Wenming Yi
Tang-luo-ning (TLN) is a traditional Chinese herbal recipe for treating diabetic peripheral neuropathy (DPN). In this study, we investigated mitochondrial protein profiles in a diabetic rat model and explored the potential protective effect of TLN. Diabetic rats were established by injection of streptozocin (STZ) and divided into model, alpha lipoic acid (ALA), and TLN groups. Mitochondrial proteins were isolated from dorsal root ganglia and proteomic analysis was used to quantify the differentially expressed proteins...
2017: BioMed Research International
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