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https://www.readbyqxmd.com/read/29451207/diabetes-its-impact-on-peripheral-nerve-regeneration-lessons-from-pre-clinical-rat-models-towards-nerve-repair-and-reconstruction
#1
Kirsten Haastert-Talini, Lars B Dahlin
No abstract text is available yet for this article.
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29447914/progression-of-primary-open-angle-glaucoma-in-diabetic-and-non-diabetic-patients
#2
Huiyuan Hou, Takuhei Shoji, Linda M Zangwill, Sasan Moghimi, Luke J Saunders, Kyle Hasenstab, Elham Ghahari, Patricia Isabel C Manalastas, Tadamichi Akagi, Mark Christopher, Rafaella C Penteado, Robert N Weinreb
PURPOSE: To compare the rates of visual field (VF) loss and retinal nerve fiber layer (RNFL) thinning in primary open angle glaucoma (POAG) patients with or without type 2 diabetes mellitus (DM). DESIGN: Cohort study. METHODS: A total of 197 eyes (55 eyes of 32 POAG patients with DM in POAG/DM group and 142 eyes of 111 age-matched POAG patients without DM in POAG/DM- group) were included from the Diagnostic Innovations in Glaucoma Study (DIGS)...
February 12, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29443416/diabetic-neuropathy-differs-between-type-1-and-type-2-diabetes-insights-from-magnetic-resonance-neurography
#3
Johann M E Jende, Jan B Groener, Dimitrios Oikonomou, Sabine Heiland, Stefan Kopf, Mirko Pham, Peter Nawroth, Martin Bendszus, Felix T Kurz
OBJECTIVE: To visualize and quantify differences of microstructural nerve damage in distal symmetric diabetic neuropathy (DPN) between type 1 diabetes (T1D) and type 2 diabetes (T2D), and to detect correlations between neuropathic symptoms and serological risk factors. METHODS: 3T magnetic resonance neurography of the sciatic nerve was performed in 120 patients (T1D n=35; T2D n=85) with either DPN (n=84) or no DPN (NDPN; n=36). Results were subsequently correlated with clinical, serological, and electrophysiological patient data...
February 14, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29436863/proinsulin-expressing-dendritic-cells-in-type-2-neuropathic-diabetic-patients-with-and-without-foot-lesions
#4
Maria Sambataro, Luisa Sambado, Enrica Trevisiol, Matilde Cacciatore, Anna Furlan, Piero Maria Stefani, Elena Seganfreddo, Elisabetta Durante, Stefania Conte, Silvia Della Bella, Agostino Paccagnella, Angelo Paolo Dei Tos
Diabetic neuropathy is the most common complication of diabetes and is frequently associated with foot ischemia and infection, but its pathogenesis is controversial. We hypothesized that proinsulin expression in peripheral blood mononuclear cells is a process relevant to this condition and could represent a link among hyperglycemia, nerve susceptibility, and diabetic foot lesions. We assessed proinsulin expression by using flow cytometry in dendritic cells from control participants and patients with type 2 diabetic with or without peripheral neuropathy or accompanied by diabetic foot...
February 12, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29434160/the-relationship-between-bladder-periarterial-and-somatic-neuropathy-in-diabetes
#5
Ryuji Sakakibara, Osamu Takahashi, Haruka Nishimura, Fuyuki Tateno, Masahiko Kishi, Yohei Tsuyusaki, Yosuke Aiba, Ichiro Tatsuno
Aims of study Diabetes commonly affects the bladder nerves. However, the relationship among bladder, periarterial and somatic neuropathy in diabetes is not well known. In the present study we investigated these relationships. Methods A total of 110 diabetic subjects were enrolled in the study. All were referred for screening for diabetic neuropathy, irrespective of their symptoms. The patients included 61 men and 49 women; the mean age was 59.3 years (31-85 years); the mean disease duration was 14.0 years (5-30 years); and the mean HbA1c value was 10...
February 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29430866/difference-in-normal-limit-values-of-nerve-conduction-parameters-between-westerner-and-japanese-people-may-need-to-be-considered-when-diagnosing-diabetic-polyneuropathy-using-a-point-of-care-sural-nerve-conduction-device-nc-stat%C3%A2-dpncheck%C3%A2
#6
Kazuhiro Hirayasu, Hideyuki Sasaki, Shohei Kishimoto, Seigo Kurisu, Koji Noda, Kenichi Ogawa, Hiroto Tanaka, Yumiko Sakakibara, Shohei Matsuno, Hiroto Furuta, Mikio Arita, Keigo Naka, Kishio Nanjo
AIM/INTRODUCTION: Studies on a novel point-of-care device for nerve conduction study called DPNCheck have been limited to Westerners. We aimed to clarify Japanese normal limits of nerve action potential (Amp) and conduction velocity (CV) by DPNCheck (Investigation-I), and validity of DPNCheck to identify diabetic symmetric sensorimotor polyneuropathy (DSPN) (Investigation-II). MATERIALS AND METHODS: Investigation-I: 463 non-neuropathic Japanese subjects underwent DPNCheck examinations...
February 11, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29429781/high-prevalence-and-incidence-of-diabetic-peripheral-neuropathy-in-children-and-adolescents-with-type-1-diabetes-mellitus-results-from-a-five-year-prospective-cohort-study
#7
Isabella Walter-Höliner, Daniela Seick Barbarini, Jürg Lütschg, Anya Blassnig-Ezeh, Ulrike Zanier, Christoph H Saely, Burkhard Simma
BACKGROUND: In this prospective cohort study, we investigated the prevalence of diabetic peripheral neuropathy at baseline and after five years of follow-up in children and adolescents with type 1 diabetes mellitus using both measurements of nerve conduction velocity and clinical neurological examination. METHODS: A total of 38 patients who underwent insulin pump or intensive insulin therapy were included. The subjects averaged 12.6 ± 2.4 years of age and their diabetes duration averaged 5...
December 13, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/29429227/-effect-of-nerve-growth-factor-on-osteogenic-potential-of-type-2-diabetic-mice-bone-marrow-stromal-cell-in-vitro
#8
G S Cui, J Y Zeng, J Zhang, R Lu
Objective: To study the effects of nerve growth factor (NGF) on the proliferation, osteogenic differentiation and mineralization of type 2 diabetic mice bone marrow stromal cell (BMSC), providing basis for clinical application of NGF. Methods: Three 8-week-old male db/db mice and two 8-week-old male C57BL/6J mice were used in the study. BMSC derived from femur were cultured though adherence method. BMSC of C57BL/6J mice and db/db mice was divided into normal group and diabetic group to conduct the osteogenic potential experiment, named experiment one...
February 9, 2018: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/29427450/reconstruction-of-the-plantar-toe-with-a-distal-reverse-instep-sensory-island-flap
#9
Mohammad Ali Hosseinian, Ali Gharibi Loron, Behzad Nemati Honar
BACKGROUND: Plantar toe ulcers are a challenging surgical problem. There are several methods for reconstruction, but no attention has been given to the preservation of sensation. This report proposes a method to provide protective sensation for the reconstructed area. PATIENTS AND METHODS: The ulcers of seven patients ranged from 2 × 3 to 7 × 3 cm with defects of the plantar first toe and distal metatarsus, including four burns, a trauma, a diabetic ulcer, and a neuropathy injury reconstructed with a distal reverse instep sensory island (DRISI) flap...
February 10, 2018: Microsurgery
https://www.readbyqxmd.com/read/29422233/nerve-function-varies-with-hemoglobin-a1c-in-controls-and-type-2-diabetes
#10
Alon Abraham, Carolina Barnett, Hans D Katzberg, Leif E Lovblom, Bruce A Perkins, Vera Bril
AIMS: To determine the cross-sectional threshold at which hemoglobin A1c (HbA1c) is associated with polyneuropathy in healthy controls, and the values associated with the most pronounced decline in nerve function in patients with diabetes. METHODS: We used data from a cross-sectional cohort study of healthy controls and type 2 diabetes patients assessed between November 2010 and May 2013. Healthy controls and patients with diabetes were compared at different HbA1c ranges: <5...
December 21, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29421993/zinc-supplementation-does-not-influence-serum-levels-of-vegf-bdnf-and-ngf-in-diabetic-retinopathy-patients-a-randomized-controlled-clinical-trial
#11
Sorayya Kheirouri, Siamak Naghizadeh, Mohammad Alizadeh
OBJECTIVES: This study was aimed to evaluate the effects of zinc (Zn) supplementation on serum levels of vascular endothelial growth factor (VEGF), brain-derived neurotrophic factor (BDNF), and nerve growth factor (NGF) in patients with diabetic retinopathy (DR). METHODS: In this randomized clinical trial, 50 patients with DR were allocated into the Zn (n = 25) and placebo (n = 25) groups to receive 30 mg Zn gluconate or maltose dextrin per day, respectively, for three months...
February 8, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29420438/retinal-nerve-fiber-layer-thickness-in-various-retinal-diseases
#12
Hyung-Bin Lim, Jae-Yun Sung, Seung-Il Ahn, Young-Joon Jo, Jung-Yeul Kim
SIGNIFICANCE: Peripapillary retinal nerve fiber layer (RNFL) thickness measurements may be influenced by the range and severity of lesions that are observed distinctively in each retinal disease. PURPOSE: We investigated the effects of various macular (central serous chorioretinopathy, macular hole, epiretinal membrane, wet age-related macular degeneration) and retinal vascular (branch retinal vein occlusion, central retinal vein occlusion, diabetic macular edema) diseases on peripapillary RNFL thickness measurements using spectral-domain optical coherence tomography...
February 7, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29419686/the-clinical-efficacy-of-epalrestat-combined-with-%C3%AE-lipoic-acid-in-diabetic-peripheral-neuropathy-protocol-for-a-systematic-review-and-meta-analysis
#13
Xiaotong Wang, Haixiong Lin, Shuai Xu, Yuanlin Jin, Ren Zhang
BACKGROUND: Diabetic peripheral neuropathy (DPN) is a common long-term complication of diabetes mellitus, affecting patients in the world. Epalrestat combined with α-lipoic acid (ALA) is the most frequent combine therapy used in the DPN researches. We aim to assess the effectiveness and safety of epalrestat combined with ALA in patients with DPN, compare with epalrestat alone. METHODS: We will search Cochrane Library, PubMed, Wanfang Data, China National Knowledge Infrastructure, VIP Chinese Science and Technology Journals Database, and Chinese Biomedical Database from inception until October 31th, 2017...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29416195/assessment-of-pharmacological-responses-to-an-anti-diabetic-drug-in-a-new-obese-type-2-diabetic-rat-model
#14
Yasutaka Murai, Takeshi Ohta, Hironobu Tadaki, Katsuhiro Miyajima, Masami Shinohara, Fatchiyah Fatchiyah, Takahisa Yamada
Introduction: The number of diabetic patients has recently been increasing worldwide, and numerous anti-diabetic drugs have been developed to induce good glycemic control. In particular, metformin, which exhibits glucose-lowering effects by suppressing gluconeogenesis in the liver, is widely used as a first line oral anti-diabetic drug for type 2 diabetes mellitus. Material and Methods: In this study, the pharmacological effects of metformin were investigated using female and male Spontaneously Diabetic Torii (SDT) fatty rats, a new obese type 2 diabetic model...
December 2017: Medical Archives
https://www.readbyqxmd.com/read/29416111/ire1%C3%AE-sirna-relieves-endoplasmic-reticulum-stress-induced-apoptosis-and-alleviates-diabetic-peripheral-neuropathy-in-vivo-and-in-vitro
#15
Weijie Yao, Xinwei Yang, Jiayue Zhu, Biane Gao, Haotian Shi, Liping Xu
Diabetic peripheral neuropathy (DPN) is mainly characterized by demyelination resulted from the apoptosis of the Schwann cell (SCs). Although the exact mechanisms underlying DPN remain unclear, endoplasmic reticulum (ER) stress is strongly implicated in the apoptosis. Under ER stress, activated inositol-requiring kinase 1α (IRE1α) unregulated CHOP, phosphorylated JNK and Caspase-12 to aggravate apoptosis-mediated damage of DPN. Therefore, we tested the hypothesis that inhibition of IRE1α could reduce the ER stress-related apoptosis to relieve DPN...
February 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29414152/inflammation-role-in-sensory-neuropathy-in-chinese-patients-with-diabetes-prediabetes
#16
Jing Zeng, Yalin Xu, Yao Shi, Chenyin Jiang
OBJECTIVES: Prediabetes involves people with glucose-metabolism impairment, and is related to different diabetic complications, like peripheral neuropathy. We aimed to explore the relationship among inflammatory (tumor necrosis factor alpha [TNFα]) and antiinflammatory (interleukin 10 [IL10]) cytokines as well as neuropathy of very distal-sensory-nerves in Chinese patients with prediabetes/diabetes. PATIENTS AND METHODS: In the present study, 55 patients having prediabetes, 55 patients having type 2 diabetes mellitus (DM), and 48 controls were included...
January 31, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29412513/determination-of-peripheral-neuropathy-in-high-fat-fed-low-dose-streptozotocin-treated-female-c57bl-6j-mice-and-sprague-dawley-rats
#17
Lawrence J Coppey, Hanna Shevalye, Alexander Obrosov, Eric P Davidson
AIMS/INTRODUCTION: Peripheral neuropathy is a common complication of diabetes and also occurs in 30% of human obese subjects with impaired glucose tolerance. Even though peripheral neuropathy affects both genders most pre-clinical studies have been performed using male rodents. The aim of this study was to create diet induced obesity and type 2 diabetes in female rats and mice in order to examine development of peripheral neuropathy. MATERIALS AND METHODS: At twelve weeks of age rats and mice were separated into three groups...
February 7, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29412501/region-specific-ischemia-neovascularization-and-macular-edema-in-treatment-na%C3%A3-ve-proliferative-diabetic-retinopathy
#18
Jason Lange, Majda Hadziahmetovic, Jingfa Zhang, Weiye Li
IMPORTANCE: Region-specific pathology in proliferative diabetic retinopathy enhances our understanding and management of this disease. BACKGROUND: To investigate non-perfusion, neovascularization, and macular edema. DESIGN: A cross-sectional, observational, non-randomized study. PARTICIPANTS: Consecutive 43 eyes of 27 treatment-naïve patients. METHODS: Ultra-widefield fluorescein angiography for studying specific zones, i...
February 7, 2018: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29412450/intrathoracic-versus-cervical-anastomosis-and-predictors-of%C3%A2-anastomotic-leakage-after-oesophagectomy-for-cancer
#19
J A H Gooszen, L Goense, S S Gisbertz, J P Ruurda, R van Hillegersberg, M I van Berge Henegouwen
BACKGROUND: Studies comparing the anastomotic leak rate in patients with an intrathoracic versus a cervical anastomosis after oesophagectomy are equivocal. The aim of this study was to compare clinical outcome after oesophagectomy in patients with an intrathoracic or cervical anastomosis, and to identify predictors of anastomotic leakage in a nationwide audit. METHODS: Between January 2011 and December 2015, all consecutive patients who underwent oesophagectomy for cancer were identified from the Dutch Upper Gastrointestinal Cancer Audit...
February 7, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29406919/correlation-between-serum-uric-acid-and-diabetic-peripheral-neuropathy-in-t2dm-patients
#20
Xiaopu Lin, Lingling Xu, Deqiang Zhao, Zhiyin Luo, Suyue Pan
AIM: To investigate the correlation between serum uric acid (SUA) and diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus (T2DM) patients. METHODS: Two hundred T2DM patients were divided into four groups at the cut-off points of 5, 7, and 9mg/dL of SUA levels. Nerve conduction studies (NCS), Semmes-Weinstein monofilament testing (SWMT), and vibration perception threshold (VPT) tests were performed on these patients. RESULTS: Significant differences in motor/sensory nerve amplitude and conduction velocity (CV) parameters among different SUA level groups were observed (all P<0...
February 15, 2018: Journal of the Neurological Sciences
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