keyword
https://read.qxmd.com/read/38222698/risk-stratification-prevention-and-management-of-perioperative-corneal-abrasion-for-non-ocular-surgery-systematic-review
#21
REVIEW
Temesgen Misganaw Liyew, Abraham Tarekegn Mersha, Belete Muluadam Admassie, Nurhusen Riskey Arefayne
BACKGROUND: A corneal abrasion is a flaw in the cornea's epithelial surface, which is located in the front of the eye. It causes recurrent erosions, corneal inflammation, and chronic corneal defects. In a context with limited resources, the goal of this review was to provide an evidence-based procedure for perioperative risk stratification, prevention, and management of corneal abrasion during non-ocular surgery. METHODS: A medical search engines of PUBMED, GOOGLE SCHOLAR, COCHRANE REVIEW, and PUBMED CENTERAL to get access for current and updated evidence on procedures on risk stratification, prevention and management of corneal abrasion for non-ocular surgery...
January 2024: Annals of Medicine and Surgery
https://read.qxmd.com/read/38201230/aberrations-in-cell-signaling-quantified-in-diabetic-murine-globes-after-injury
#22
JOURNAL ARTICLE
Nicholas A Azzari, Kristen L Segars, Srikar Rapaka, Landon Kushimi, Celeste B Rich, Vickery Trinkaus-Randall
The corneal epithelium is an avascular structure that has a unique wound healing mechanism, which allows for rapid wound closure without compromising vision. This wound healing mechanism is attenuated in diabetic patients, resulting in poor clinical outcomes and recurrent non-healing erosion. We investigated changes in cellular calcium signaling activity during the wound response in murine diabetic tissue using live cell imaging from both ex vivo and in vitro models. The calcium signaling propagation in diabetic cells was significantly decreased and displayed altered patterns compared to non-diabetic controls...
December 21, 2023: Cells
https://read.qxmd.com/read/38154886/analysis-of-cardiovascular-risk-factors-for-the-viability-of-cornea-donors-a-case-control-study
#23
JOURNAL ARTICLE
Alejandro Montero-Salinas, Santiago Martínez-Isasi, Eva Fieira-Costa, Jorge Suanzes-Hernández, Daniel Fernández-García, Juan Gómez-Salgado, Esther Rendal-Vazquez
OBJECTIVE: The main objective of the study was to evaluate the influence of arterial hypertension, diabetes, dyslipidaemia, smoking, alcoholism and COPD (chronic obstructive pulmonary disease) on the viability of the extracted tissue as well as the donor. DESIGN: Observational case-control study. SETTING: Regional hospital in Northern Spain. PARTICIPANTS: 1517 corneas were registered. INTERVENTIONS: Patients' medical history was reviewed after corneal donation and evaluation...
December 28, 2023: BMJ Open
https://read.qxmd.com/read/38141818/ocular-surface-changes-in-mice-with-streptozotocin-induced-diabetes-and-diabetic-polyneuropathy
#24
JOURNAL ARTICLE
Martin Schicht, Jessica Farger, Saskia Wedel, Marco Sisignano, Klaus Scholich, Gerd Geisslinger, Natarajan Perumal, Franz H Grus, Swati Singh, Afsun Sahin, Friedrich Paulsen, Elke Lütjen-Drecoll
PURPOSE: Diabetes mellitus (DM) is a leading risk factor for corneal neuropathy and dry eye disease (DED). Another common consequence of DM is diabetic peripheral polyneuropathy (DPN). Both complications affect around 50 % of the DM patients but the relationship between DM, DED and DPN remains unclear. METHODS: In this study, we examined mice with early onset of DM and PN after streptozotocin (STZ)-induced diabetes (DPN). We compared the early morphological changes of the sciatic nerve, dorsal root and trigeminal ganglia with the changes in the ocular surface, including tear proteomic and we also investigated respective changes in the gene expressions and morphological alterations in the eye tissues involved in tear production...
December 21, 2023: Ocular Surface
https://read.qxmd.com/read/38136625/effects-of-1-25-vitamin-d3-and-24-25-vitamin-d3-on-corneal-nerve-regeneration-in-diabetic-mice
#25
JOURNAL ARTICLE
Xiaowen Lu, Zhong Chen, Jerry Lu, Mitchell A Watsky
Corneal nerve homeostasis is essential for the functional integrity of the ocular surface. Vitamin D deficiency (VDD) and vitamin D receptor knockout (VDR KO) have been found to reduce corneal nerve density in diabetic mice. This is the first study to comprehensively examine the influence of vitamin D on nerve regeneration following corneal epithelial injury in diabetic mice. Corneal nerve regeneration was significantly retarded by diabetes, VDR KO, and VDD, and it was accelerated following topical 1,25 Vit D and 24,25 Vit D administration...
December 6, 2023: Biomolecules
https://read.qxmd.com/read/38019489/correlation-between-corneal-whorl-like-nerve-and-retinal-neurodegenerative-changes-and-their-association-with-microvessel-perfusion-in-diabetes
#26
JOURNAL ARTICLE
Dongyu Li, Xin Jin, Chao Wang, Nan Zhang, Di Jin, Hong Zhang
PURPOSE: The purpose of this study was to compare the evolution of changes in the corneal nerves, retinal nerves, and cells and blood vessels at a single time point in early diabetic retinopathy (DR). METHODS: Eighty participants (60 with diabetes and 20 nondiabetic controls) were examined. DR was graded according to the International Classification of Diabetic Retinopathy. Inferior whorl length (IWL), spiral orientation, central nerve fiber length (CNFL), retinal nerve fiber layer (RNFL) thickness, ganglion cell complex (GCC) layer thickness, global loss volume (GLV), focal loss volume (FLV) indices, superficial (sVD), and deep vessel densities (dVD) were examined...
November 1, 2023: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38016033/donor-risk-factors-and-environmental-conditions-associated-with-poor-quality-corneas-an-analysis-of-the-central-eye-bank-of-iran-2018-2021
#27
JOURNAL ARTICLE
Fatemeh Javadi, Zahra Khorrami, Sadra Ashrafi, Mohammad Abolhosseini, Mozhgan Rezaei Kanavi, Sare Safi
PURPOSE: The purpose of this study was to investigate the donor risk factors and environmental conditions associated with poor-quality corneas using the database of the Central Eye Bank of Iran over 4 years. METHODS: This cohort study was conducted on the recorded data of all donated corneas at the Central Eye Bank of Iran database from March 2018 to March 2022. Donors' characteristics and tissue variables were extracted from the database. The final corneal quality was determined based on slitlamp biomicroscopic observations and the results of specular microscopy...
November 28, 2023: Cornea
https://read.qxmd.com/read/37998149/a-novel-combination-therapy-t%C3%AE-4-vip-protects-against-hyperglycemia-induced-changes-in-human-corneal-epithelial-cells
#28
JOURNAL ARTICLE
Abdul Shukkur Ebrahim, Thomas W Carion, Thanzeela Ebrahim, Jeff Win, Hussein Kani, Yuxin Wang, Ashten Stambersky, Ahmed S Ibrahim, Gabriel Sosne, Elizabeth A Berger
Despite the prevalence of diabetic retinopathy, the majority of adult diabetic patients develop visually debilitating corneal complications, including impaired wound healing. Unfortunately, there is limited treatment for diabetes-induced corneal damage. The current project investigates a novel, peptide-based combination therapy, thymosin beta-4 and vasoactive intestinal peptide (Tβ4/VIP), against high-glucose-induced damage to the corneal epithelium. Electric cell-substrate impedance sensing (ECIS) was used for real-time monitoring of barrier function and wound healing of human corneal epithelial cells maintained in either normal glucose (5 mM) or high glucose (25 mM) ± Tβ4 (0...
November 7, 2023: Biosensors
https://read.qxmd.com/read/37989326/use-of-yamane-technique-for-secondary-intraocular-lens-implantation-following-open-globe-injury
#29
JOURNAL ARTICLE
Jonathan Thomas, Grayson Armstrong
A woman in her 50s presented with suspected open globe injury (OGI) of the right eye after being hit with a high velocity piece of plastic. Visual acuity at the time of presentation was counting fingers in the affected eye. Slit lamp examination revealed a full thickness laceration of the cornea and a traumatic cataract. Primary corneal repair was performed and the patient was left aphakic after cataract removal. Secondary intraocular lens placement was deferred for 2 years, after which time a scleral-fixated intraocular lens was implanted using the Yamane technique...
November 21, 2023: BMJ Case Reports
https://read.qxmd.com/read/37947602/microrna-and-protein-cargos-of-human-limbal-epithelial-cell-derived-exosomes-and-their-regulatory-roles-in-limbal-stromal-cells-of-diabetic-and-non-diabetic-corneas
#30
JOURNAL ARTICLE
Nagendra Verma, Drirh Khare, Adam J Poe, Cynthia Amador, Sean Ghiam, Andrew Fealy, Shaghaiegh Ebrahimi, Odelia Shadrokh, Xue-Ying Song, Chintda Santiskulvong, Mitra Mastali, Sarah Parker, Aleksandr Stotland, Jennifer E Van Eyk, Alexander V Ljubimov, Mehrnoosh Saghizadeh
Epithelial and stromal/mesenchymal limbal stem cells contribute to corneal homeostasis and cell renewal. Extracellular vesicles (EVs), including exosomes (Exos), can be paracrine mediators of intercellular communication. Previously, we described cargos and regulatory roles of limbal stromal cell (LSC)-derived Exos in non-diabetic (N) and diabetic (DM) limbal epithelial cells (LECs). Presently, we quantify the miRNA and proteome profiles of human LEC-derived Exos and their regulatory roles in N- and DM-LSC. We revealed some miRNA and protein differences in DM vs...
October 25, 2023: Cells
https://read.qxmd.com/read/37944849/cell-sheet-based-approach-to-study-the-diabetic-corneal-stroma
#31
JOURNAL ARTICLE
Shrestha Priyadarsini, Tina B McKay, Paulina Escandon, Sarah E Nicholas, Jian-Xing Ma, Dimitrios Karamichos
Prolonged hyperglycemia during diabetes mellitus (DM) is associated with severe complications that may affect both the anterior and posterior ocular segments, leading to impaired vision or blindness. The cornea is a vital part of the eye that has a dual role as a protective transparent barrier and as a major refractive structure and is likewise negatively affected by hyperglycemia in DM. Understanding the cellular and molecular mechanisms underlying the phenotypic changes associated with DM is critical to developing targeted therapies to promote tissue integrity...
December 2023: Experimental Eye Research
https://read.qxmd.com/read/37938936/diabetes-associated-hyperglycemia-causes-rapid-onset-ocular-surface-damage
#32
JOURNAL ARTICLE
Judy Weng, Christopher Ross, Jacob Baker, Saleh Alfuraih, Kiumars Shamloo, Ajay Sharma
PURPOSE: The metabolic alterations due to chronic hyperglycemia are well-known to cause diabetes-associated complications. Short-term hyperglycemia has also been shown to cause many acute changes, including hemodynamic alterations and osmotic, oxidative, and inflammatory stress. The present study was designed to investigate whether diabetes-associated hyperglycemia can cause rapid-onset detrimental effects on the tear film, goblet cells, and glycocalyx and can lead to activation of an inflammatory cascade or cellular stress response in the cornea...
November 1, 2023: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/37913875/silk-fibroin-derived-electrospun-materials-for-biomedical-applications-a-review
#33
REVIEW
Francisco Vieira Dos Santos, Renato Luiz Siqueira, Lucas de Morais Ramos, Sérgio Akinobu Yoshioka, Márcia Cristina Branciforti, Daniel Souza Corrêa
Electrospinning is a versatile technique for fabricating polymeric fibers with diameters ranging from micro- to nanoscale, exhibiting multiple morphologies and arrangements. By combining silk fibroin (SF) with synthetic and/or natural polymers, electrospun materials with outstanding biological, chemical, electrical, physical, mechanical, and optical properties can be achieved, fulfilling the evolving biomedical demands. This review highlights the remarkable versatility of SF-derived electrospun materials, specifically focusing on their application in tissue regeneration (including cartilage, cornea, nerves, blood vessels, bones, and skin), disease treatment (such as cancer and diabetes), and the development of controlled drug delivery systems...
October 30, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/37899288/central-corneal-thickness-and-intraocular-pressure-in-children-with-type-i-diabetes-mellitus
#34
JOURNAL ARTICLE
Mohmad Zulhisham, Hussain Suhaimi, Ismail Shatriah
PURPOSE: The aim of this study is to determine the mean central corneal thickness (CCT) and mean intraocular pressure (IOP) in children with type 1 diabetes mellitus (T1DM) and to determine the relationship between CCT and IOP on the one hand and age, gender, retinopathy hemoglobin A1c (HbA1c), and duration of diabetes on the other. METHODS: This is a case-control, hospital-based study conducted at Hospital ___________ between January and November 2022. Thirty-eight children with T1DM were recruited as cases, and 38 healthy children were recruited as controls...
October 25, 2023: Korean Journal of Ophthalmology: KJO
https://read.qxmd.com/read/37887302/limbal-epithelial-stem-cells-in-the-diabetic-cornea
#35
REVIEW
Lamia Nureen, Nick Di Girolamo
Continuous replenishment of the corneal epithelium is pivotal for maintaining optical transparency and achieving optimal visual perception. This dynamic process is driven by limbal epithelial stem cells (LESCs) located at the junction between the cornea and conjunctiva, which is otherwise known as the limbus. In patients afflicted with diabetes, hyperglycemia-induced impairments in corneal epithelial regeneration results in persistent epithelial and other defects on the ocular surface, termed diabetic keratopathy (DK), which progressively diminish vision and quality of life...
October 16, 2023: Cells
https://read.qxmd.com/read/37854375/evaluation-of-corneal-backward-light-scattering-in-type-2-diabetes-mellitus
#36
JOURNAL ARTICLE
Amira Elagamy, Najd Abaalhassan, Mohamed Berika
AIM: To compare the corneal backward light scattering values in type 2 diabetes mellitus (DM) patients with those of age and sex-matched healthy controls. METHODS: The study included 30 patients (30 eyes) with type 2 DM and 30 control subjects (30 eyes). Duration of diabetes, most recent hemoglobin A1c levels, along with the status of diabetic retinopathy, and existing medical treatment of all subjects were recorded. All subjects underwent a complete ophthalmologic examination...
2023: International Journal of Ophthalmology
https://read.qxmd.com/read/37850222/recurrence-of-gigantic-overhanging-bleb-post-excision-a-case-report
#37
Kirti Singh, Mainak Bhattacharyya, Ravinder Saran, Nikhil Gotmare, Himshikha Aggarwal, Pragya Jain
PURPOSE: To report the case of an extremely large overhanging bleb, extending from superior fornix to limbus, in a 57-year-old poorly controlled diabetic, six years after trabeculectomy for an uncontrolled primary open angle glaucoma (POAG) with recurrence, months after complete excision. METHODS: An overhanging bleb is defined as a filtering cicatrix which has been massaged downward over the cornea by eyelid action. It has been linked to anti-metabolite use during glaucoma filtering surgery...
2023: GMS Ophthalmology Cases
https://read.qxmd.com/read/37775045/protective-effect-of-pituitary-adenylate-cyclase-activating-polypeptide-in-diabetic-keratopathy
#38
JOURNAL ARTICLE
Grazia Maugeri, Agata Grazia D'Amico, Benedetta Magrì, Salvatore Giunta, Salvatore Saccone, Concetta Federico, Claudio Bucolo, Giuseppe Musumeci, Velia D'Agata
Diabetic keratopathy (DK) is the major complication of the cornea characterizing diabetes-affected patients. This ocular pathology is correlated with the hyperglycemic state leading to delayed corneal wound healing and recurrent corneal ulcers. Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide with widespread distribution throughout the body, and exerting cytoprotective effects in the neural and non-neuronal parts of the eye, including the cornea. The purpose of the present study was to investigate whether changes in PACAP expression can concur for delayed epithelial wound healing in diabetic cornea and whether the protective effect of the peptide could be mediated through the activation of the EGFR signaling pathway, which has been reported to be impaired in DK...
September 27, 2023: Peptides
https://read.qxmd.com/read/37760810/chronic-kidney-disease-has-no-impact-on-tear-film-substance-p-concentration-in-type-2-diabetes
#39
JOURNAL ARTICLE
Kofi Asiedu, Sultan Alotaibi, Arun V Krishnan, Natalie Kwai, Ann Poynten, Maria Markoulli, Roshan Dhanapalaratnam
PURPOSE: The study aimed to ascertain the potential effects of chronic kidney disease (CKD) on substance P concentration in the tear film of people with type 2 diabetes. METHODS: Participants were classified into two groups: type 2 diabetes with concurrent chronic kidney disease (T2DM-CKD (n = 25)) and type 2 diabetes without chronic kidney disease (T2DM-no CKD (n = 25)). Ocular surface discomfort assessment, flush tear collection, in-vivo corneal confocal microscopy, and peripheral neuropathy assessment were conducted...
August 24, 2023: Biomedicines
https://read.qxmd.com/read/37756520/diabetes-induced-changes-of-the-rat-erg-in-relation-to-hyperglycemia-and-acidosis
#40
JOURNAL ARTICLE
Andrey V Dmitriev, Alexander A Dmitriev, Robert A Linsenmeier
PURPOSE: To understand the mechanism of changes in the c-wave of the electroretinogram (ERG) in diabetic rats, and to explore how glucose manipulations affect the c-wave. METHODS: Vitreal ERGs were recorded in control and diabetic Long-Evans rats, three to 60 weeks after IP vehicle or streptozotocin. A few experiments were performed on Brown Norway rats. Voltage responses to current pulses were used to measure the transepithelial resistance of the retinal pigment epithelium (RPE)...
September 27, 2023: Current Eye Research
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