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Diabetes cornea

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https://www.readbyqxmd.com/read/29776352/surgical-peripheral-iridectomy-via-a-clear-cornea-phacoemulsification-incision-for-pupillary-block-following-cataract-surgery-in-acute-angle-closure
#1
Aiwu Fang, Peijuan Wang, Rui He, Jia Qu
BACKGROUND: To describe a technique of surgical peripheral iridectomy via a clear-cornea tunnel incision to prevent or treat pupillary block following phacoemulsification. METHODS: Description of technique and retrospective description results in 20 eyes of 20 patients with acute angle closure with coexisting visually significant cataract undergoing phacoemulsification considered at risk of postoperative papillary block as well as two pseudo-phakic eyes with acute postoperative pupillary-block...
May 18, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29746333/effect-of-diabetes-mellitus-and-metformin-on-central-corneal-endothelial-cell-density-in-eye-bank-eyes
#2
Isaac M Chocron, Dinesh K Rai, Ji-Won Kwon, Nicole Bernstein, Jimmy Hu, Moonseong Heo, Jimmy K Lee, Patrick K Gore, Mitchell D McCartney, Roy S Chuck
PURPOSE: To determine whether metformin use and diabetes mellitus (DM) affect central corneal endothelial cell density (ECD) by examining an eye bank corneal donor database. METHODS: The Lions Eye Institute corneal donor database, which consists of 38,318 corneal samples, was examined. Associations of ECD with metformin use and DM were tested by mixed effects linear models that account for correlations of outcomes between eyes within subjects adjusting for age, intraocular lens status, and glaucoma...
May 4, 2018: Cornea
https://www.readbyqxmd.com/read/29728238/a-fully-automated-cell-segmentation-and-morphometric-parameter-system-for-quantifying-corneal-endothelial-cell-morphology
#3
Shumoos Al-Fahdawi, Rami Qahwaji, Alaa S Al-Waisy, Stanley Ipson, Maryam Ferdousi, Rayaz A Malik, Arun Brahma
BACKGROUND AND OBJECTIVE: Corneal endothelial cell abnormalities may be associated with a number of corneal and systemic diseases. Damage to the endothelial cells can significantly affect corneal transparency by altering hydration of the corneal stroma, which can lead to irreversible endothelial cell pathology requiring corneal transplantation. To date, quantitative analysis of endothelial cell abnormalities has been manually performed by ophthalmologists using time consuming and highly subjective semi-automatic tools, which require an operator interaction...
July 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29688226/wide-field-corneal-subbasal-nerve-plexus-mosaics-in-age-controlled-healthy-and-type-2-diabetes-populations
#4
Neil S Lagali, Stephan Allgeier, Pedro Guimarães, Reza A Badian, Alfredo Ruggeri, Bernd Köhler, Tor Paaske Utheim, Beatrice Peebo, Magnus Peterson, Lars B Dahlin, Olov Rolandsson
A dense nerve plexus in the clear outer window of the eye, the cornea, can be imaged in vivo to enable non-invasive monitoring of peripheral nerve degeneration in diabetes. However, a limited field of view of corneal nerves, operator-dependent image quality, and subjective image sampling methods have led to difficulty in establishing robust diagnostic measures relating to the progression of diabetes and its complications. Here, we use machine-based algorithms to provide wide-area mosaics of the cornea's subbasal nerve plexus (SBP) also accounting for depth (axial) fluctuation of the plexus...
April 24, 2018: Scientific Data
https://www.readbyqxmd.com/read/29643724/resolvin-d1-promotes-corneal-epithelial-wound-healing-and-restoration-of-mechanical-sensation-in-diabetic-mice
#5
Zhenzhen Zhang, Xiaoli Hu, Xia Qi, Guohu Di, Yangyang Zhang, Qian Wang, Qingjun Zhou
Purpose: To investigate the effect and mechanism of proresolving lipid mediator resolvin D1 (RvD1) on the corneal epithelium and the restoration of mechanical sensation in diabetic mice. Methods: Type 1 diabetes was induced in mice with intraperitoneal streptozocin injections. The healthy and diabetic mice underwent removal of the central corneal epithelium, and then 100 ng/ml RvD1 or its formyl peptide receptor 2 (FPR2) antagonist WRW4 was used to treat the diabetic mice...
2018: Molecular Vision
https://www.readbyqxmd.com/read/29642830/-a-new-strategy-for-enhancing-acanthamoebicidal-activity-with-synthesis-of-nanoflower-of-laurocerausus-officinalis-roemer-cherry-laurel-fruit-extracts
#6
Ayşe Baldemir, Ülkü Karaman, Sadi Yusufbeyoğlu, Ayşe Eken, Nilay Ildız, Selen İlgün, Cemil Çolak, Gamze Kaçmaz, İsmail Öçsoy, Soner Çankaya
Pathogenic Acanthamoeba species often cause infection known as Acanthamoeba keratitis among people who use contact lenses. It is a type of infection that can result in corneal ulceration, visual loss or even blindness, if not treated. There are various therapeutic options available in the treatment of Acanthamoeba infections but they are usually tough treatments with limited efficacy. For instance, hydrogen peroxide (H2 O2 ) is a commonly used contact lens disinfectant which is effective against Acanthamoeba but it is toxic to the cornea...
January 2018: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29625482/distribution-pattern-of-choroidal-thickness-at-the-posterior-pole-in-chinese-children-with-myopia
#7
Junjie Deng, Xiaoli Li, Jiali Jin, Bo Zhang, Jianfeng Zhu, Haidong Zou, Xun Xu, Jingbo Xie, Ling Wang, Shaopin Zhu, Xiangui He
Purpose: To determine the relationship between choroidal thickness (ChT) at the posterior pole and refractive error and to explore the difference between the macular and peripapillary regions in children with myopia. Methods: A total of 340 healthy Chinese children underwent a series of comprehensive ocular examinations including cycloplegic refraction. Swept-source optical coherence tomography was used to measure the ChT in the macular and peripapillary regions...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29615440/inhibition-of-soluble-epoxide-hydrolase-2-ameliorates-diabetic-keratopathy-and-impaired-wound-healing-in-mouse-corneas
#8
Haijing Sun, Patrick Lee, Chenxi Yan, Nan Gao, Jiemei Wang, Xianqun Fan, Fu-Shin Yu
EPHX2 (soluble Epoxide Hydrolase 2, sEH) converts biologically active epoxyeicosatrienoic acids (EETs), anti-inflammatory and pro-fibrinolytic effectors into the less biologically active metabolites, dihydroxyeicostrienoic acids. We sought to characterize the expression and the function of EPHX2 in diabetic corneas and during wound healing. The expression of EPHX2 at both mRNA and protein levels, as well as sEH enzymatic activity, were markedly upregulated in the tissues/cells, including corneal epithelial cells as well as the retina of human type-2, mouse type-1 (STZ-induced) and/or type-2 diabetes...
April 3, 2018: Diabetes
https://www.readbyqxmd.com/read/29599653/corneal-innervation-and-sensation-the-eye-and-beyond
#9
REVIEW
Alina Y Yang, Jessica Chow, Ji Liu
The cornea is one of the most densely innervated and sensitive tissues in the body. In addition to their important sensory functions, corneal nerves induce reflex tear production, blinking, and the release of trophic factors - all of which combined help to maintain the structural and functional integrity of the surface of the eye. Consequently, damage to corneal nerves as a result of disease, surgery, or trauma can lead to diminished corneal sensitivity, epithelial defects, and possible blindness. In this review, we describe commonly used tools that have provided considerable new information on corneal architecture and sensation in healthy and diseased corneas, with special emphasis on changes seen in herpes zoster ophthalmicus, corneal and other therapeutic ocular procedures, antiglaucoma medical therapy, aging, and diabetes...
March 2018: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/29596948/what-is-the-best-strategy-on-detection-of-cornea-neuropathy-in-people-with-diabetes-recent-advances-in-potential-measurements
#10
REVIEW
Ying Lv, Shaozhen Zhao
There are well-acknowledged clinical or pre-clinical measurements concerning diabetic peripheral neuropathy(DPN). The current gold standard for diagnosis of diabetic peripheral neuropathy is nerve conduction suitable for detecting large nerve fiber function[1] and intraepidermal nerve fiber density assessment for small fiber damage evaluation[2]. The lack of a sensitive, non-invasive, and repeatable endpoint to measure changes in small nerve fibers is a major factor holding back clinical trials for the treatment of diabetic peripheral neuropathy...
March 26, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29578513/puncture-induced-iris-neovascularization-as-a-mouse-model-of-rubeosis-iridis
#11
Filippo Locri, Monica Aronsson, Ophélie Beaujean, Anders Kvanta, Helder André
We describe a model of puncture-induced iris neovascularization as a general model for noninvasive evaluation of angiogenesis. The model is also relevant for targeting neovascular glaucoma, a sight-threatening complication of diabetic retinopathy. This method is based on the induction of iris vascular response by a series of self-sealing uveal punctures on BALB/c mice and takes advantage of the postpartum maturation of mouse ocular vasculature. Mouse pups undergo uveal punctures from postnatal day 12.5, when the pups naturally open their eyes, until postnatal day 24...
March 8, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29545417/prevalence-and-causes-of-vision-loss-in-high-income-countries-and-in-eastern-and-central-europe-in-2015-magnitude-temporal-trends-and-projections
#12
Rupert R A Bourne, Jost B Jonas, Alain M Bron, Maria Vittoria Cicinelli, Aditi Das, Seth R Flaxman, David S Friedman, Jill E Keeffe, John H Kempen, Janet Leasher, Hans Limburg, Kovin Naidoo, Konrad Pesudovs, Tunde Peto, Jinan Saadine, Alexander J Silvester, Nina Tahhan, Hugh R Taylor, Rohit Varma, Tien Y Wong, Serge Resnikoff
BACKGROUND: Within a surveillance of the prevalence and causes of vision impairment in high-income regions and Central/Eastern Europe, we update figures through 2015 and forecast expected values in 2020. METHODS: Based on a systematic review of medical literature, prevalence of blindness, moderate and severe vision impairment (MSVI), mild vision impairment and presbyopia was estimated for 1990, 2010, 2015, and 2020. RESULTS: Age-standardised prevalence of blindness and MSVI for all ages decreased from 1990 to 2015 from 0...
March 15, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29541513/glycerol-dehydration-of-native-and-diabetic-animal-tissues-studied-by-thz-tds-and-nmr-methods
#13
O A Smolyanskaya, I J Schelkanova, M S Kulya, E L Odlyanitskiy, I S Goryachev, A N Tcypkin, Ya V Grachev, Ya G Toropova, V V Tuchin
The optical clearing method has been widely used for different spectral ranges where it provides tissue transparency. In this work, we observed the enhanced penetration of the terahertz waves inside biological samples (skin, kidney, and cornea) treated with glycerol solutions inducing changes of optical and dielectric properties. It was supported by the observed trend of free-to-bound water ratio measured by the nuclear magnetic resonance (NMR) method. The terahertz clearing efficiency was found to be less for diabetic samples than for normal ones...
March 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29533244/thin-rigid-contact-lens-used-in-vitreous-retinal-surgery-for-corneal-protection-a-randomized-controlled-trial
#14
Zizhong Hu, Yuzhi Ding, Xinhua Zheng, Songtao Yuan, Jia Li, Ping Xie, Qinghuai Liu
PURPOSE: To design a rigid contact lens (CL) to be used in combination with a wide-angle viewing system and analyze its protection for corneal epithelial during vitreous-retinal surgery. METHODS: A thin and lightweight rigid CL was designed and constructed. The impact of the CL on the visualized fundus range was evaluated using a concrete eye model. Patients with severe proliferative diabetic retinopathy (PDR) were randomized to either the CL group, corneal protective agent (CPA) group, or balanced salt solution (BSS) group...
March 12, 2018: Eye & Contact Lens
https://www.readbyqxmd.com/read/29529022/proteomic-analysis-of-corneal-endothelial-cell-descemet-membrane-tissues-reveals-influence-of-insulin-dependence-and-disease-severity-in-type-2-diabetes-mellitus
#15
Jessica M Skeie, Benjamin T Aldrich, Andrew S Goldstein, Gregory A Schmidt, Cynthia R Reed, Mark A Greiner
The objective of this study was to characterize the proteome of the corneal endothelial cell layer and its basement membrane (Descemet membrane) in humans with various severities of type II diabetes mellitus compared to controls, and identify differentially expressed proteins across a range of diabetic disease severities that may influence corneal endothelial cell health. Endothelium-Descemet membrane complex tissues were peeled from transplant suitable donor corneas. Protein fractions were isolated from each sample and subjected to multidimensional liquid chromatography and tandem mass spectrometry...
2018: PloS One
https://www.readbyqxmd.com/read/29498968/descemet-membrane-endothelial-keratoplasty-learning-curve-for-graft-preparation-in-an-eye-bank-using-645-donor-corneas
#16
Mohit Parekh, Alessandro Ruzza, Vito Romano, Elisa Favaro, Mattia Baruzzo, Gianni Salvalaio, Andrea Grassetto, Stefano Ferrari, Diego Ponzin
PURPOSE: To investigate the learning curve of Descemet membrane endothelial keratoplasty (DMEK) graft preparation in an eye bank. METHODS: Four operators prepared 645 DMEK grafts using the stripping technique between 2014 and 2017 at the Veneto Eye Bank Foundation, Italy. Endothelial cell loss (ECL) and tissue wastage were recorded retrospectively after DMEK preparation and correlated with the number of tissues prepared each year by each operator. On average, our operators performed 1 donor preparation a week over the course of this study...
June 2018: Cornea
https://www.readbyqxmd.com/read/29459766/greater-corneal-nerve-loss-at-the-inferior-whorl-is-related-to-the-presence-of-diabetic-neuropathy-and-painful-diabetic-neuropathy
#17
Alise Kalteniece, Maryam Ferdousi, Ioannis Petropoulos, Shazli Azmi, Safwaan Adam, Hassan Fadavi, Andrew Marshall, Andrew J M Boulton, Nathan Efron, Catharina G Faber, Giuseppe Lauria, Handrean Soran, Rayaz A Malik
We assessed whether a measure of more distal corneal nerve fibre loss at the inferior whorl(IW) region is better than proximal measures of central corneal nerve damage in relation to the diagnosis of diabetic peripheral neuropathy(DPN), painful DPN and quality of life(QoL). Participants underwent detailed assessment of neuropathy, QoL using the SF36 questionnaire, pain visual analogue score(VAS), and corneal confocal microscopy(CCM). Corneal nerve fibre density (CNFD), branch density (CNBD) and length (CNFL) at the central cornea and inferior whorl length (IWL) and average(ANFL) and total(TNFL) nerve fibre length were compared in patients with and without DPN and between patients with and without painful DPN and in relation to QoL...
February 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29412513/determination-of-peripheral-neuropathy-in-high-fat-diet-fed-low-dose-streptozotocin-treated-female-c57bl-6j-mice-and-sprague-dawley-rats
#18
Lawrence J Coppey, Hanna Shevalye, Alexander Obrosov, Eric P Davidson, Mark A Yorek
AIMS/INTRODUCTION: Peripheral neuropathy is a common complication of diabetes and also occurs in 30% of human obese individuals with impaired glucose tolerance. Even though peripheral neuropathy affects both sexes, most pre-clinical studies have been carried out using male rodents. The aim of the present study was to create diet-induced obesity and type 2 diabetes in female rats and mice in order to examine the development of peripheral neuropathy. MATERIALS AND METHODS: At 12 weeks-of-age, rats and mice were separated into three groups...
February 7, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29397395/the-expression-of-calcium-sensing-receptor-in-normal-and-diabetic-rat-eyes
#19
Ping Jiang, Rong Huang, Nan Ma, Fagang Jiang
BACKGROUND Calcium sensing receptor (CaSR) is widely expressed in many tissues of the body, but it is rarely reported to be expressed in the eyes. This research explored the expression and distribution of CaSR in eye tissues of normal and diabetic rats. MATERIAL AND METHODS Thirty male Sprague Dawley (SD) rats were randomly divided into a diabetic and a normal group. Diabetes mellitus (DM) models were successfully established by intraperitoneal injection of streptozotocin. The expression and distribution of CaSR in the rat eyeballs were detected by immunohistochemistry...
February 4, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29384804/reduction-in-histone-h3-acetylation-and-chromatin-remodeling-in-corneas-of-alloxan-induced-diabetic-rats
#20
Karina E Herencia-Bueno, Marcela Aldrovani, Roberta M Crivelaro, Roberto Thiesen, Alexandre A F Barros-Sobrinho, Flor D Y Claros-Chacaltana, Ivan R M Padua, Daniela M Santos, José L Laus
PURPOSE: To evaluate acetylation of histone H3, chromatin remodeling, nuclear size and shape, DNA ploidy, and distribution of nucleolus organizing regions (NORs) in corneal epithelial and stromal cells of diabetic and nondiabetic rats. METHODS: Diabetes was induced by a single intraperitoneal injection of alloxan. All diabetic rats (n = 20) included in the study had 4 weeks of moderate-to-severe hyperglycemia (plasma glucose levels >400 mg/dL). Acetylated histone H3 levels were quantified in corneal tissue using a colorimetric assay...
May 2018: Cornea
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