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Diabetes cornea

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https://www.readbyqxmd.com/read/28810264/mesenchymal-stem-cells-promote-diabetic-corneal-epithelial-wound-healing-through-tsg-6-dependent-stem-cell-activation-and-macrophage-switch
#1
Guohu Di, Xianli Du, Xia Qi, Xiaowen Zhao, Haoyun Duan, Suxia Li, Lixin Xie, Qingjun Zhou
Purpose: To explore the role and mechanism of bone marrow-derived mesenchymal stem cells (BM-MSCs) in corneal epithelial wound healing in type 1 diabetic mice. Methods: Diabetic mice were treated with subconjunctival injections of BM-MSCs or recombinant tumor necrosis factor-α-stimulated gene/protein-6 (TSG-6). The corneal epithelial wound healing rate was examined by fluorescein staining. The mRNA and protein expression levels of TSG-6 were measured by quantitative RT-PCR and Western blot...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28757399/diabetic-retinopathy-an-overview
#2
EDITORIAL
M Elizabeth Hartnett, Wolfgang Baehr, Yun Z Le
This overview introduces contributions to a special issue on causes of vision loss from diabetes mellitus, focusing on the retina and also the cornea. Diabetic retinopathy is the most common and leading cause of vision loss among people with diabetes. Research to detect early symptoms, understand mechanisms leading to diabetic eye disease, and the development of treatments is a highly active research area, with currently about 2000 scientific publication per year. We provide a series of 27 comprehensive reviews and research articles from leading experts in the field...
July 27, 2017: Vision Research
https://www.readbyqxmd.com/read/28742617/simple-single-pass-technique-for-ultrathin-descemet-stripping-automated-endothelial-keratoplasty-a-pilot-study
#3
Maria E S Dimitry, Adam D Lewis, Fani Zacharaki, Manju Chandran, Deana Robson, Geeta Menon, Thomas R G Poole
PURPOSE: To assess intraoperative and postoperative graft thickness (GT) after donor deturgescence for ultrathin Descemet stripping automated endothelial keratoplasty and to evaluate visual outcomes, endothelial cell density, and patient satisfaction at 1 year. METHODS: Prospective interventional case series of patients with Fuchs endothelial dystrophy, Fuchs endothelial dystrophy and cataract, and pseudophakic bullous keratopathy (n = 12 grafts). The donor cornea was allowed to thin out by simple evaporation on an artificial anterior chamber, to the required precut thickness, before a single microkeratome pass...
July 24, 2017: Cornea
https://www.readbyqxmd.com/read/28650386/corneal-nerve-morphology-and-tear-film-substance-p-in-diabetes
#4
Maria Markoulli, Jingjing You, Juno Kim, Carmen L Duong, Jonathan B Tolentino, Joshua Karras, Edward Lum
PURPOSE: This work aims to characterize the relationship between tear film neuropeptide substance P and the structural integrity of the sub-basal nerve plexus in diabetes. METHODS: Seventeen healthy control participants and nine participants with diabetes were recruited in this cross-sectional study. Total protein content and substance P concentrations were determined in the flush tears of participants. Corneal nerve morphology was assessed by capturing the corneal sub-basal nerve plexus using the Heidelberg Retinal Tomograph II with the Rostock Corneal Module (Heidelberg Engineering GmbH, Heidelberg, Germany) in the central cornea...
July 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28632845/iris-malformation-and-anterior-segment-dysgenesis-in-mice-and-humans-with-a-mutation-in-pi-3-kinase
#5
Marie H Solheim, Allen C Clermont, Jonathon N Winnay, Erlend Hallstensen, Anders Molven, Pål R Njølstad, Eyvind Rødahl, C Ronald Kahn
Purpose: To determine the ocular consequences of a dominant-negative mutation in the p85α subunit of phosphatidylinositol 3-kinase (PIK3R1) using a knock-in mouse model of SHORT syndrome, a syndrome associated with short stature, lipodystrophy, diabetes, and Rieger anomaly in humans. Methods: We investigated knock-in mice heterozygous for the SHORT syndrome mutation changing arginine 649 to tryptophan in p85α (PIK3R1) using physical examination, optical coherence tomography (OCT), tonometry, and histopathologic sections from paraffin-embedded eyes, and compared the findings to similar investigations in two human subjects with SHORT syndrome heterozygous for the same mutation...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28615632/genome-wide-analysis-suggests-a-differential-microrna-signature-associated-with-normal-and-diabetic-human-corneal-limbus
#6
Mangesh Kulkarni, Aleksandra Leszczynska, Gabbie Wei, Michael A Winkler, Jie Tang, Vincent A Funari, Nan Deng, Zhenqiu Liu, Vasu Punj, Sophie X Deng, Alexander V Ljubimov, Mehrnoosh Saghizadeh
Small non-coding RNAs, in particular microRNAs (miRNAs), regulate fine-tuning of gene expression and can impact a wide range of biological processes. However, their roles in normal and diseased limbal epithelial stem cells (LESC) remain unknown. Using deep sequencing analysis, we investigated miRNA expression profiles in central and limbal regions of normal and diabetic human corneas. We identified differentially expressed miRNAs in limbus vs. central cornea in normal and diabetic (DM) corneas including both type 1 (T1DM/IDDM) and type 2 (T2DM/NIDDM) diabetes...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28603017/effects-of-diabetes-mellitus-on-biomechanical-properties-of-the-rabbit-cornea
#7
FangJun Bao, ManLi Deng, XiaoBo Zheng, LinNa Li, YiPing Zhao, Si Cao, AYong Yu, QinMei Wang, JinHai Huang, Ahmed Elsheikh
To investigate the effects of diabetes on the biomechanical behavior of cornea in alloxan-induced diabetic rabbits. Diabetes mellitus (DM) was induced in 20 rabbits using alloxan, while another 20 age- and weight-matched non-diabetic rabbits served as controls. Eyes were enucleated after 8 weeks of inducing diabetes and the whole cornea was removed with a 3 mm wide scleral ring and tested under inflation conditions with an internal pressure range of 2.0-30.0 mmHg to determine their stress-strain behavior using an inverse analysis process...
August 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28592408/recovery-of-corneal-sensitivity-and-increase-in-nerve-density-and-wound-healing-in-diabetic-mice-after-pedf-plus-dha-treatment
#8
Jiucheng He, Thang Luong Pham, Azucena Kakazu, Haydee E P Bazan
Diabetic keratopathy decreases corneal sensation and tear secretion, and delays wound healing after injury. In the current study, we tested the effect of treatment with pigment epithelium-derived factor (PEDF) in combination with docosahexaenoic acid (DHA) on corneal nerve regeneration in a mouse model of diabetes with or without corneal injury. The study was performed in streptozotocin (STZ)-induced diabetic mice (C57BL/6). Ten weeks after STZ injection, diabetic mice showed significant decreases of corneal sensitivity, tear production and epithelial subbasal nerve density when compared with age-matched normal mice...
June 7, 2017: Diabetes
https://www.readbyqxmd.com/read/28490481/vitamin-a-deficiency-due-to-chronic-malabsorption-an-ophthalmic-manifestation-of-a-systemic-condition
#9
James Cheshire, Sai Kolli
A 47-year-old woman presented with a 4-week history of progressive loss of vision, first manifesting as night blindness. Additionally, the patient reported frequent severe episodes of diarrhoea over the past month. Her medical history included end-stage renal failure for which she was currently on haemodialysis after a failed renal transplant, chronic pancreatitis and autonomic diabetes mellitus. Ophthalmological examination revealed severe bilateral corneal xerosis, bilateral Bitot's spots and inferior ulceration of the right cornea...
May 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28451994/3d-stacked-construct-a-novel-substitute-for-corneal-tissue-engineering
#10
Shrestha Priyadarsini, Sarah E Nicholas, Dimitrios Karamichos
Corneal trauma/injury often results in serious complications including permanent vision loss or loss of visual acuity which demands corneal transplantations or treatment with allogenic graft tissues. There is currently a huge shortage of donor tissue worldwide and the need for human corneal equivalents increases annually. In order to meet such demand the current clinical approach of treating corneal injuries is limited and involves synthetic and allogenic materials which have various shortcomings when it comes to actual transplantations...
April 28, 2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28404521/diabetic-complications-in-the-cornea
#11
Alexander V Ljubimov
Diabetic corneal alterations, such as delayed epithelial wound healing, edema, recurrent erosions, neuropathy/loss of sensitivity, and tear film changes are frequent but underdiagnosed complications of both type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus. The disease affects corneal epithelium, corneal nerves, tear film, and to a lesser extent, endothelium, and also conjunctiva. These abnormalities may appear or become exacerbated following trauma, as well as various surgeries including retinal, cataract or refractive...
April 28, 2017: Vision Research
https://www.readbyqxmd.com/read/28395029/mitochondrial-and-morphologic-alterations-in-native-human-corneal-endothelial-cells-associated-with-diabetes-mellitus
#12
Benjamin T Aldrich, Ursula Schlötzer-Schrehardt, Jessica M Skeie, Kimberlee A Burckart, Gregory A Schmidt, Cynthia R Reed, M Bridget Zimmerman, Friedrich E Kruse, Mark A Greiner
Purpose: To characterize changes in the energy-producing metabolic activity and morphologic ultrastructure of corneal endothelial cells associated with diabetes mellitus. Methods: Transplant suitable corneoscleral tissue was obtained from donors aged 50 to 75 years. We assayed 3-mm punches of endothelium-Descemet membrane for mitochondrial respiration and glycolysis activity using extracellular flux analysis of oxygen and pH, respectively. Transmission electron microscopy was used to assess qualitative and quantitative ultrastructural changes in corneal endothelial cells and associated Descemet membrane...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28378047/-confocal-microscope-examination-of-the-corneal-nerve-plexus-as-biomarker-for-systemic-diseases-view-from-the-corneal-nerve-plexus-on-diabetes-mellitus-disease
#13
S Baltrusch
It is estimated that approximately 50% of patients with diabetes mellitus suffer from polyneuropathy, which is frequently diagnosed too late. Consequently, the question arises whether imaging procedures of the eye, namely optical coherence tomography of the retina and confocal microscopy of the cornea are suitable for the diagnostics and follow-up control of neurodegenerative changes in patients with diabetes mellitus. De Clerck and co-workers could demonstrate this by a systematic review of studies. Of these studies 11 were further evaluated with respect to corneal confocal microscopy...
July 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28319106/a-systematic-review-on-the-impact-of-diabetes-mellitus-on-the-ocular-surface
#14
REVIEW
K Co Shih, K S-L Lam, L Tong
Diabetes mellitus is associated with extensive morbidity and mortality in any human community. It is well understood that the burden of diabetes is attributed to chronic progressive damage in major end-organs, but it is underappreciated that the most superficial and transparent organ affected by diabetes is the cornea. Different corneal components (epithelium, nerves, immune cells and endothelium) underpin specific systemic complications of diabetes. Just as diabetic retinopathy is a marker of more generalized microvascular disease, corneal nerve changes can predict peripheral and autonomic neuropathy, providing a window of opportunity for early treatment...
March 20, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/28306601/assessing-the-impact-of-diabetes-mellitus-on-donor-corneal-endothelial-cell-density
#15
Chase A Liaboe, Benjamin T Aldrich, Pamela C Carter, Jessica M Skeie, Kimberlee A Burckart, Gregory A Schmidt, Cynthia R Reed, M Bridget Zimmerman, Mark A Greiner
PURPOSE: To quantify changes in endothelial cell density (ECD) of donor corneal tissue in relation to the presence or absence of a medical history of diabetes mellitus diagnosis, treatment, and complications. METHODS: A retrospective review was performed for all corneas collected at Iowa Lions Eye Bank between January 2012 and December 2015. For purposes of analysis, donor corneas were divided into 4 groups: nondiabetic, non-insulin-dependent diabetic, insulin-dependent diabetic without medical complications due to diabetes, and insulin-dependent diabetic with medical complications due to diabetes...
May 2017: Cornea
https://www.readbyqxmd.com/read/28296766/evaluation-of-socioeconomic-status-as-a-risk-factor-of-pterygium-using-the-korean-national-health-and-nutrition-examination-survey-2010-to-2011-a-strobe-compliant-article
#16
Young Bok Lee, Su Young Kim, Yong Gyu Park, Kyung Do Han, Jin-Wou Kim, Hiun Suk Chae, Young Chun Lee
Pterygium is a common conjunctival disorder. The socioeconomic risk factors of pterygium have not been systematically evaluated in Korea. The study investigated risk factors of pterygium considering socioeconomic status.Participants were 9839 adults aged 19 to 74 years, who underwent ophthalmic slit-lamp examinations as part of the Korean National Health and Nutrition Examination Survey 2010 to 2011. Pterygium was diagnosed as a growth of fibrovascular tissue over the cornea. The socioeconomic risk factors were analyzed in association with the presence of pterygium...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28280298/corneal-endothelium-and-central-corneal-thickness-changes-in-type-2-diabetes-mellitus
#17
Amira El-Agamy, Shams Alsubaie
PURPOSE: This study was conducted to compare the corneal endothelial cell density (ECD), morphological features, and central corneal thickness (CCT) in type 2 diabetes mellitus (DM) with age-matched, nondiabetic control subjects using EM-3000 Specular Microscope. STUDY DESIGN: This was a prospective, hospital-based, nonrandomized, case-control, observational, and quantitative study. SUBJECTS AND METHODS: The study included 57 patients (57 eyes) with type 2 DM and 45 control (nondiabetic) subjects (45 eyes)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28258973/rapid-automated-mosaicking-of-the-human-corneal-subbasal-nerve-plexus
#18
Yash J Vaishnav, Stuart A Rucker, Keshav Saharia, Nancy A McNamara
Corneal confocal microscopy (CCM) is an in vivo technique used to study corneal nerve morphology. The largest proportion of nerves innervating the cornea lie within the subbasal nerve plexus, where their morphology is altered by refractive surgery, diabetes and dry eye. The main limitations to clinical use of CCM as a diagnostic tool are the small field of view of CCM images and the lengthy time needed to quantify nerves in collected images. Here, we present a novel, rapid, fully automated technique to mosaic individual CCM images into wide-field maps of corneal nerves...
March 4, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28115875/pediatric-endogenous-haemophilus-influenzae-endophthalmitis-with-presumed-hyposplenism
#19
Masatoshi Haruta, Yumiko Yoshida, Ryoji Yamakawa
BACKGROUND: Endogenous bacterial endophthalmitis is a rare but potentially devastating intraocular infection that can have severe sight-threatening complications. Most patients with endogenous bacterial endophthalmitis have underlying infectious conditions, such as diabetes or malignancy, which predispose them to infection. CASE REPORT: A 1-year-old girl presented with cloudiness of the right eye. Ocular examination showed a cloudy cornea in the right eye with conjunctival injection and hypopyon...
2017: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/28033432/association-between-endothelial-cell-density-and-transplant-suitability-of-corneal-tissue-with-type-1-and-type-2-diabetes
#20
Jordan A Margo, Wuqaas M Munir, Clayton H Brown, Caroline K Hoover
Importance: The rate of types 1 and 2 diabetes in the United States is increasing. The effect of diabetes on corneal donor tissue is unknown. Objectives: To determine the association between endothelial cell density and suitability for transplantation in cornea donors with type 1 or 2 diabetes and determine the effect of diabetes on technician-induced endothelial damage during cornea donor tissue processing. Design, Setting, and Participants: Donor information was obtained from the SightLife Eye Bank for donors from June 1, 2012, to June 30, 2015...
December 29, 2016: JAMA Ophthalmology
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