keyword
MENU ▼
Read by QxMD icon Read
search

Diabetes cornea

keyword
https://www.readbyqxmd.com/read/27877085/the-evolving-functions-of-autophagy-in-ocular-health-a-double-edged-sword
#1
REVIEW
Peiwei Chai, Hongyan Ni, He Zhang, Xianqun Fan
Autophagy plays an adaptive role in cell survival, development, differentiation and intracellular homeostasis. Autophagy is recognized as a 'self-cannibalizing' process that is active during stresses such as starvation, chemotherapy, infection, ageing, and oxygen shortage to protect organisms from various irritants and to regenerate materials and energy. However, autophagy can also lead to a form of programmed cell death distinct from apoptosis. Components of the autophagic pathway are constitutively expressed at a high level in the eye, including in the cornea, lens, retina, and orbit...
2016: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/27843433/successful-treatment-of-lasiodiplodia-theobromae-keratitis-assessing-the-role-of-voriconazole
#2
Stephen Tak-Lun Li, Evan Po-Fat Yiu, Angela Hiu-Yan Wong, John Chun-Ting Yeung, Lester Wang-Hon Yu
PURPOSE: The aim of this paper is to report the successful management of the first case of Lasiodiplodia theobromae keratitis in Hong Kong. METHODS: We conducted a case report. RESULTS: A 43-year-old Chinese male with a history of diabetes developed left eye keratitis after a trauma during tree felling. Fungal keratitis was diagnosed using a confocal microscope on day 1, and L. theobromae was confirmed from the culture. He was given oral voriconazole, topical natamycin, and topical and intracameral amphotericin B...
September 2016: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/27777123/descemet-membrane-adhesion-strength-is-greater-in-diabetics-with-advanced-disease-compared-to-healthy-donor-corneas
#3
Chaid Schwarz, Benjamin T Aldrich, Kimberlee A Burckart, Gregory A Schmidt, M Bridget Zimmerman, Cynthia R Reed, Mark A Greiner, Edward A Sander
Descemet membrane endothelial keratoplasty (DMEK) is an increasingly popular surgical procedure for treating ocular diseases that require a corneal transplant. Previous studies have found that tissue tearing during surgical preparation is more likely elevated in eyes from donors with a history of diabetes mellitus. To quantify these potential differences, we established an experimental technique for quantifying the force required to separate the endothelium-Descemet membrane complex (EDM) from stroma in human donor corneal tissue, and we assessed differences in adhesion strength between diabetic and non-diabetic donor corneas...
October 21, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27774316/effect-of-treatment-with-salsalate-menhaden-oil-combination-of-salsalate-and-menhaden-oil-or-resolvin-d1-of-c57bl-6j-type-1-diabetic-mouse-on-neuropathic-endpoints
#4
Matthew S Yorek, Lawrence J Coppey, Hanna Shevalye, Alexander Obrosov, Randy H Kardon, Mark A Yorek
Aims. In this study a streptozotocin induced type 1 diabetes mouse model was used to assess the effectiveness of salsalate, menhaden oil, the combination of salsalate and menhaden oil, or resolvin D1 on neuropathic endpoints. Materials and Methods. Changes in body weight, blood glucose, serum markers for triglycerides, free fatty acids, cholesterol, and resolvin D1, motor and sensory nerve conduction velocities and thermal sensitivity were assessed, as well as performing in vivo confocal microscopy of subepithelial corneal nerves and immunohistochemistry of nerves in the cornea and foot pad...
2016: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/27771327/in-vivo-confocal-microscopy-of-corneal-nerves-in-health-and-disease
#5
Andrea Cruzat, Yureeda Qazi, Pedram Hamrah
In vivo confocal microscopy (IVCM) is becoming an indispensable tool for studying corneal physiology and disease. Enabling the dissection of corneal architecture at a cellular level, this technique offers fast and noninvasive in vivo imaging of the cornea with images comparable to that of ex vivo histochemical techniques. Corneal nerves bear substantial relevance to clinicians and scientists alike, given their pivotal roles in regulation of corneal sensation, maintenance of epithelial integrity, and proliferation and promotion of wound healing...
October 19, 2016: Ocular Surface
https://www.readbyqxmd.com/read/27760856/high-throughput-screens-to-discover-small-molecule-modulators-of-ryanodine-receptor-calcium-release-channels
#6
Robyn T Rebbeck, Maram M Essawy, Florentin R Nitu, Benjamin D Grant, Gregory D Gillispie, David D Thomas, Donald M Bers, Razvan L Cornea
Using time-resolved fluorescence resonance energy transfer (FRET), we have developed and validated the first high-throughput screening (HTS) method to discover compounds that modulate an intracellular Ca(2+) channel, the ryanodine receptor (RyR), for therapeutic applications. Intracellular Ca(2+) regulation is critical for striated muscle function, and RyR is a central player. At resting [Ca(2+)], an increased propensity of channel opening due to RyR dysregulation is associated with severe cardiac and skeletal myopathies, diabetes, and neurological disorders...
October 19, 2016: Journal of Biomolecular Screening
https://www.readbyqxmd.com/read/27749499/assessment-of-corneal-backward-light-scattering-in-diabetic-patients
#7
Pelin Özyol, Erhan Özyol
OBJECTIVES: To analyze corneal backward light scattering differences in patients with type 2 diabetes mellitus. METHODS: We enrolled 43 eyes from 43 diabetic patients and 40 eyes from 40 healthy controls. Corneal backward light scattering was evaluated using densitometry measurements from different corneal layers and zones obtained using Scheimpflug tomography (PentacamHR). RESULTS: When densitometry values were divided by depth, anterior layer of diabetic corneas displayed significantly higher corneal backward light scattering values than controls (32...
October 3, 2016: Eye & Contact Lens
https://www.readbyqxmd.com/read/27742548/complete-metabolome-and-lipidome-analysis-reveals-novel-biomarkers-in-the-human-diabetic-corneal-stroma
#8
Shrestha Priyadarsini, Tina B McKay, Akhee Sarker-Nag, Jeremy Allegood, Charles Chalfant, Jian-Xing Ma, Dimitrios Karamichos
Prolonged hyperglycemia during diabetes mellitus can cause severe ophthalmic complications affecting both the anterior and posterior ocular segments leading to impaired vision or blindness. Diabetes-induced corneal pathologies are associated with decreased wound healing capacity, corneal edema, and altered epithelial basement membrane. The mechanism by which diabetes modulates structure and function within the corneal stroma are unknown. In our study, we characterized the effects of diabetes on extracellular matrix, lipid transport, and cellular metabolism by defining the entire metabolome and lipidome of Type 1 and Type 2 human diabetic corneal stroma...
October 11, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27660697/in-vivo-corneal-confocal-microscopy-in-diabetes-where-we-are-and-where-we-can-get
#9
REVIEW
Ernesto Maddaloni, Francesco Sabatino
In vivo corneal confocal microscopy (IVCCM) is a novel, reproducible, easy and noninvasive technique that allows the study of the different layers of the cornea at a cellular level. As cornea is the most innervated organ of human body, several studies investigated the use of corneal confocal microscopy to detect diabetic neuropathies, which are invalidating and deadly complications of diabetes mellitus. Corneal nerve innervation has been shown impaired in subjects with diabetes and a close association between damages of peripheral nerves due to the diabetes and alterations in corneal sub-basal nerve plexus detected by IVCCM has been widely demonstrated...
September 15, 2016: World Journal of Diabetes
https://www.readbyqxmd.com/read/27659544/a-randomized-multicenter-clinical-trial-of-ultrathin-descemet-stripping-automated-endothelial-keratoplasty-dsaek-versus-dsaek
#10
Mor M Dickman, Pieter J Kruit, Lies Remeijer, Jeroen van Rooij, Allegonda Van der Lelij, Robert H J Wijdh, Frank J H M van den Biggelaar, Tos T J M Berendschot, Rudy M M A Nuijts
OBJECTIVE: To compare visual acuity, refraction, endothelial cell density (ECD), and complications after Descemet stripping automated endothelial keratoplasty (DSAEK) and ultrathin DSAEK (UT-DSAEK). DESIGN: A multicenter, prospective, double-masked, randomized, controlled clinical trial. PARTICIPANTS: From 66 patients with irreversible corneal endothelial dysfunction dues to Fuchs' dystrophy who enrolled from 4 tertiary medical centers in the Netherlands, 66 eyes were studied...
September 19, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27623389/corneal-thickness-differences-between-type-2-diabetes-and-non-diabetes-subjects-during-preoperative-laser-surgery-examination
#11
Juan A Sanchis-Gimeno, Luis Alonso, Mohammed Rahhal, Markus Bastir, Marcelino Perez-Bermejo, Lurdes Belda-Salmeron
AIMS: To evaluate the differences in corneal thickness between type 2 diabetes subjects with HbA1c under 7.0% and non-diabetes subjects during their preoperative laser surgery examinations. METHODS: The mean of five consecutive corneal thickness measurements at the central and mid-peripheral cornea was obtained by means of noncontact scanning-slit corneal topography (Orbscan Topography System II; Orbscan, Inc., Salt Lake City, UT, USA) in 35 myopic non-insulin dependent type 2 diabetes subjects (17 males and 18 females) and 48 healthy myopic controls (23 males and 25 females)...
August 28, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27618414/diabetes-impairs-the-aldehyde-detoxifying-capacity-of-the-retina
#12
Rosemary E McDowell, Mary K McGahon, Josy Augustine, Mei Chen, J Graham McGeown, Tim M Curtis
PURPOSE: We studied whether the accumulation of advanced lipoxidation end-products (ALEs) in the diabetic retina is linked to the impairment of lipid aldehyde detoxification mechanisms. METHODS: Retinas were collected from nondiabetic and diabetic rats and processed for conventional and quantitative RT-PCR (qRT-PCR), Western blotting, immunohistochemistry, and aldehyde dehydrogenase (ALDH) activity assays. The effect of the ALDH1a1 inhibitor, NCT-501, on ALE accumulation and cell viability in cultured Müller glia also was investigated...
September 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27611469/insulin-restores-an-altered-corneal-epithelium-circadian-rhythm-in-mice-with-streptozotocin-induced-type-1-diabetes
#13
Fang Song, Yunxia Xue, Dong Dong, Jun Liu, Ting Fu, Chengju Xiao, Hanqing Wang, Cuipei Lin, Peng Liu, Jiajun Zhong, Yabing Yang, Zhaorui Wang, Hongwei Pan, Jiansu Chen, Yangqiu Li, Dongqing Cai, Zhijie Li
The mechanisms of corneal epithelial lesions and delayed wound repair, as well as their association with diabetes mellitus, are critical issues for clinical ophthalmologists. To test whether the diabetic condition alters the circadian rhythm in a mouse cornea and whether insulin can synchronise the corneal clock, we studied the effects of streptozotocin-induced diabetes on the mitosis of epithelial cells, the recruitment of leukocytes to the cornea, and the expression of main core clock genes (Clock, Bmal1, Per2, Cry1, and Rev-erbα) in the corneal epithelium...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27602094/corneal-hydrops-induced-by-diabetic-ketoacidosis-a-case-report
#14
Meiyan Feng, Chao Wang
To the best of our knowledge, there have been no reports of corneal hydrops associated with diabetic ketoacidosis. The present study first reports a case of a 20-year-old male patient with diabetic ketoacidosis-induced corneal hydrops. The patient exhibited mild hydrops in their left eyelid, which was accompanied by mixed hyperemia, and hazy turbid in a white color was observed in the cornea. To alleviate the corneal hydrops, 5% glucose was administered dropwise to the left eye for 2 h to alleviate the inflammation...
September 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27601446/early-detection-of-diabetic-neuropathy-by-investigating-cnfl-and-ienfd-in-thy1-yfp-mice
#15
Janine Leckelt, Pedro Guimarães, Annett Kott, Alfredo Ruggeri, Oliver Stachs, Simone Baltrusch
Small fiber neuropathy is one of the most common and painful long-term complications of diabetes mellitus. Examination of the subbasal corneal nerve plexus is a promising surrogate marker of diabetic neuropathy. To investigate the efficacy, reliability and reproducibility of in vivo corneal confocal microscopy (IVCCM), we used thy1-YFP mice, which express yellow fluorescence protein (YFP) in nerve fibers. Four weeks after multiple low-dose injections of streptozotocin, thy1-YFP mice showed manifest diabetes...
September 6, 2016: Journal of Endocrinology
https://www.readbyqxmd.com/read/27588277/distribution-of-intraocular-pressure-and-its-determinants-in-an-iranian-adult-population
#16
Hassan Hashemi, Mehdi Khabazkhoob, Mohammad Hassan Emamian, Mohammad Shariati, Abbasali Yekta, Akbar Fotouhi
AIM: To determine the distribution of intraocular pressure (IOP) and its determinants in an Iranian population. METHODS: In a cross-sectional survey, random cluster sampling was conducted from the 40-64 years old population of Shahroud, in the north of Iran. All participants had optometry and ophthalmic exams. IOP was determined using the Goldmann tonometry method and biometric components were measured. RESULTS: Of the 6311 people selected for the study, 5190 (82...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27586488/a-fully-automatic-nerve-segmentation-and-morphometric-parameter-quantification-system-for-early-diagnosis-of-diabetic-neuropathy-in-corneal-images
#17
Shumoos Al-Fahdawi, Rami Qahwaji, Alaa S Al-Waisy, Stanley Ipson, Rayaz A Malik, Arun Brahma, Xin Chen
Diabetic Peripheral Neuropathy (DPN) is one of the most common types of diabetes that can affect the cornea. An accurate analysis of the nerve structures can assist the early diagnosis of this disease. This paper proposes a robust, fast and fully automatic nerve segmentation and morphometric parameter quantification system for corneal confocal microscope images. The segmentation part consists of three main steps. First, a preprocessing step is applied to enhance the visibility of the nerves and remove noise using anisotropic diffusion filtering, specifically a Coherence filter followed by Gaussian filtering...
October 2016: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/27572140/in-vivo-retinal-and-choroidal-hypoxia-imaging-using-a-novel-activatable-hypoxia-selective-near-infrared-fluorescent-probe
#18
Shinichi Fukuda, Kensuke Okuda, Genichiro Kishino, Sujin Hoshi, Itsuki Kawano, Masahiro Fukuda, Toshiharu Yamashita, Simone Beheregaray, Masumi Nagano, Osamu Ohneda, Hideko Nagasawa, Tetsuro Oshika
PURPOSE: Retinal hypoxia plays a crucial role in ocular neovascular diseases, such as diabetic retinopathy, retinopathy of prematurity, and retinal vascular occlusion. Fluorescein angiography is useful for identifying the hypoxia extent by detecting non-perfusion areas or neovascularization, but its ability to detect early stages of hypoxia is limited. Recently, in vivo fluorescent probes for detecting hypoxia have been developed; however, these have not been extensively applied in ophthalmology...
December 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27555566/abnormal-anterior-corneal-morphology-in-diabetes-observed-using-in%C3%A2-vivo-laser-scanning-confocal-microscopy
#19
Cirous Dehghani, Nicola Pritchard, Katie Edwards, Anthony W Russell, Rayaz A Malik, Nathan Efron
PURPOSE: To assess if diabetes alters corneal epithelial, anterior stromal and subbasal nerve plexus morphology and to determine the associations between these and other clinical variables. METHODS: A cohort of 78 participants with diabetes (39 with Type 1 and 39 with Type 2 diabetes) and 29 age-matched healthy controls underwent laser-scanning confocal microscopy of the central cornea. Intermediate cell density (ICD), basal cell density (BCD), anterior stromal cell density (ASCD), corneal nerve fiber density (CNFD) and nerve fiber length (CNFL) were quantified...
October 2016: Ocular Surface
https://www.readbyqxmd.com/read/27485702/the-association-between-diabetes-and-herpes-simplex-eye-disease
#20
Mustafa Kosker, Kristin M Hammersmith, Parveen K Nagra, Ahmad H Nassef, Christopher J Rapuano
PURPOSE: To evaluate the association between diabetes mellitus (DM) and presence and severity of Herpes simplex eye disease (HSED). METHODS: We conducted two sub-studies. We included the patients seen on the Cornea Service of the Wills Eye Hospital from January 2008 to August 2012. Study 1 included 541 patients with HSED and 3226 controls. Study 2 involved 40 diabetic and 120 non-diabetic ocular surface HSED patients. Severity of ocular surface HSED was graded as mild, moderate, or severe, based on best-corrected visual acuity (BCVA)...
August 2, 2016: Ocular Immunology and Inflammation
keyword
keyword
25882
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"