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Descemet's membrane

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https://www.readbyqxmd.com/read/28938379/dark-endothelial-spots-after-descemet-membrane-endothelial-keratoplasty-may-appear-as-recurrent-fuchs-dystrophy-or-herald-graft-failure-or-rejection
#1
Vasiliki Zygoura, Lamis Baydoun, Claire Monnereau, Maria Satué, Silke Oellerich, Gerrit R J Melles
PURPOSE: To evaluate the clinical significance of dark spots in the donor endothelial cell layer as observed with specular microscopy, in patients who underwent Descemet membrane endothelial keratoplasty (DMEK) for Fuchs endothelial dystrophy (FED). METHODS: Specular microscopy images of 83 consecutive eyes up to 7 years after DMEK were retrospectively reviewed in a masked fashion for the presence of dark spots and morphologic changes in the endothelial cell layer and processed for endothelial cell density (ECD) measurements...
September 21, 2017: Cornea
https://www.readbyqxmd.com/read/28937824/clinical-comparison-of-two-methods-of-graft-preparation-in-descemet-membrane-endothelial-keratoplasty
#2
Annekatrin Rickmann, Natalia Opitz, Peter Szurman, Karl Thomas Boden, Sacha Jung, Silke Wahl, Arno Haus, Lara-Jil Damm, Kai Januschowski
PURPOSE: Descemet membrane endothelial keratoplasty (DMEK) has been improved over the last decade. The aim of this study was to compare the clinical outcome of the recently introduced liquid bubble method compared to the standard manual preparation. METHODS: This retrospective study evaluated the outcome of 200 patients after DMEK surgery using two different graft preparation techniques. Ninety-six DMEK were prepared by manual dissection and 104 by the novel liquid bubble technique...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28934248/vps35-deficiency-impairs-slc4a11-trafficking-and-promotes-corneal-dystrophy
#3
Wei Liu, Fu-Lei Tang, Sen Lin, Kai Zhao, Lin Mei, Jian Ye, Wen-Cheng Xiong
Vps35 (vacuolar protein sorting 35) is a major component of retromer that selectively promotes endosome-to-Golgi retrieval of transmembrane proteins. Dysfunction of retromer is a risk factor for the pathogenesis of Parkinson's disease (PD) and Alzheimer's disease (AD). However, Vps35/retromer's function in the eye or the contribution of Vps35-deficiency to eye degenerative disorders remains to be explored. Here we provide evidence for a critical role of Vps35 in mouse corneal dystrophy. Vps35 is expressed in mouse and human cornea...
2017: PloS One
https://www.readbyqxmd.com/read/28933958/transplantation-of-human-corneal-endothelial-cells-cultured-on-bio-engineered-collagen-vitrigel-in-a-rabbit-model-of-corneal-endothelial-dysfunction
#4
Junko Yoshida, Seiichi Yokoo, Ayumi Oshikata-Miyazaki, Shiro Amano, Toshiaki Takezawa, Satoru Yamagami
PURPOSE: To evaluate the effect of transplanting bioengineered corneal endothelial grafts in a rabbit model of corneal endothelial failure. METHODS: Human corneal endothelial cells (HCECs) were seeded on a vitrigel carrier. After Descemet's membrane was removed from the eyes of rabbits, transplantation was done with a vitrigel/HCEC graft or vitrigel alone without cells, or the eyes were left untreated. Slit lamp examinations and measurement of the central corneal thickness (CCT) were performed for 14 days postoperatively...
September 21, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28932339/penetrating-keratoplasty-for-keratoconus-excimer-versus-femtosecond-laser-trephination
#5
Berthold Seitz, Achim Langenbucher, Tobias Hager, Edgar Janunts, Moatasem El-Husseiny, Nora Szentmáry
BACKGROUND: In case of keratoconus, rigid gas-permeable contact lenses as the correction method of first choice allow for a good visual acuity for quite some time. In a severe stage of the disease with major cone-shaped protrusion of the cornea, even specially designed keratoconus contact lenses are no more tolerated. In case of existing contraindications for intrastromal ring segments, corneal transplantation typically has a very good prognosis. METHODS: In case of advanced keratoconus - especially after corneal hydrops due to rupture of Descemet's membrane - penetrating keratoplasty (PKP) still is the surgical method of first choice...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28928909/transplanting-embryonic-stem-cells-onto-damaged-human-corneal-endothelium
#6
Charles Hanson, Arsaell Arnarsson, Thorir Hardarson, Ann Lindgård, Mandana Daneshvarnaeini, Catarina Ellerström, Anita Bruun, Ulf Stenevi
AIM: To investigate whether human embryonic stem cells (hESCs) could be made to attach, grow and differentiate on a human Descemet's membrane (DM). METHODS: Spontaneously differentiated hESCs were transferred onto a human corneal button with the endothelial layer removed using ocular sticks. The cells were cultured on a DM for up to 15 d. The genetically engineered hESC line expressed green fluorescent protein, which facilitated identification during the culture experiments, tissue preparation, and analysis...
August 26, 2017: World Journal of Stem Cells
https://www.readbyqxmd.com/read/28926889/-clinical-research-progress-in-endothelial-keratoplasty
#7
Y Y Zhang, L X Xie
Endothelial keratoplasty (EK) has gradually replaced penetrating keratoplasty (PKP) and has become the main method for the treatment of endothelial dysfunction in developed countries in recent years. EK is safe and effective and can achieve good postoperative vision. The surgical techniques and postoperative effects have been improved continuously along with the development of microsurgical technology and surgical instruments. The EK surgeries mainly include Descemet stripping endothelial keratoplasty (DSEK), Descemet stripping automated endothelial keratoplasty (DSAEK), Descemet membrane endothelial keratoplasty (DMEK) and ultra-thin Descemet stripping automated endothelial keratoplasty (UT-DSAEK), which have different characteristics and advantages compared with PKP...
September 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28923499/descemet-membrane-endothelial-keratoplasty-safety-and-outcomes-a-report-by-the-american-academy-of-ophthalmology
#8
Sophie X Deng, W Barry Lee, Kristin M Hammersmith, Anthony N Kuo, Jennifer Y Li, Joanne F Shen, Mitchell P Weikert, Roni M Shtein
PURPOSE: To review the published literature on the safety and outcomes of Descemet membrane endothelial keratoplasty (DMEK) for the surgical treatment of corneal endothelial dysfunction. METHODS: Literature searches were last conducted in the PubMed and the Cochrane Library databases most recently in May 2017. The searches, which were limited to English-language abstracts, yielded 1085 articles. The panel reviewed the abstracts, and 47 were determined to be relevant to this assessment...
September 15, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28922331/descemet-membrane-thickening-as-a-sign-for-the-diagnosis-of-corneal-graft-rejection-an-ex-vivo-study
#9
Ryan VanDenBerg, Vasilios F Diakonis, Alison Bozung, Gustavo Rosa Gameiro, Oliver Fischer, Ahmed El Dakkak, Jan Paul Ulloa-Padilla, Apostolos Anagnostopoulos, Sander Dubovy, Mohamed Abou Shousha
PURPOSE: To disclose, using an ex vivo study, the histopathological mechanism behind in vivo thickening of the endothelium/Descemet membrane complex (En/DM) observed in rejected corneal grafts (RCGs). METHODS: Descemet membrane (DM), endothelium, and retrocorneal membranes make up the total En/DM thickness. These layers are not differentiable by high-definition optical coherence tomography; therefore, the source of thickening is unclear from an in vivo perspective...
September 14, 2017: Cornea
https://www.readbyqxmd.com/read/28915807/descemet-membrane-detachment-in-femtosecond-laser-assisted-cataract-surgery-a-case-report
#10
Peiqing Chen, Yanan Zhu, Ke Yao
BACKGROUND: Femtosecond laser-assisted cataract surgery (FLACS) has grown in popularity among ophthalmologists as a novel technique. However, descemet membrane detachment (DMD) began to be found as the complication after FLACS. We report a case of serious DMD following FLACS due to the inappropriate incision design. CASE PRESENTATION: An 85-year-old man with apparent cornea arcus senilis underwent femtosecond laser-assisted cataract surgery in his right eye. A biplanar model was chosen for the main incision...
September 16, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28902856/effect-of-vital-dyes-on-human-corneal-endothelium-and-elasticity-of-descemet-s-membrane
#11
Isabell P Weber, Mrinal Rana, Peter B M Thomas, Ivan B Dimov, Kristian Franze, Madhavan S Rajan
The purpose of this study was to evaluate the effects of vital dyes on human Descemet's membranes (DMs) and endothelia. DMs of 25 human cadaveric corneas with research consent were treated with dyes routinely used in Descemet membrane endothelial keratoplasty (DMEK), 0.05% Trypan blue (TB) or a combination of 0.15% Trypan blue, 0.025% Brilliant blue and 4% Polyethylene glycol (commercial name Membrane Blue Dual; MB). The effects of these two dyes on (i) endothelial cell viability, (ii) DM mechanical properties as assessed by atomic force microscopy, and iii) qualitative DM dye retention were tested for two varying exposure times (one or four minutes)...
2017: PloS One
https://www.readbyqxmd.com/read/28902013/-bubble-in-the-roll-technique-using-the-endoject-dmek-injector-influence-of-the-air-bubble-on-endothelial-cell-loss
#12
Yasemin Akbaba, Julia M Weller, Kathrin Rössler, W John Armitage, Ursula Schlötzer-Schrehardt, Friedrich E Kruse, Theofilos Tourtas
PURPOSE: To evaluate the impact of the air bubble on endothelial cell loss using the "bubble-in-the-roll" technique during Descemet membrane endothelial keratoplasty (DMEK). METHODS: Twenty DMEK grafts not suitable for transplantation were manually prepared from organ-cultured corneoscleral discs and injected into culture media using the Endoject DMEK injector (Medicel AG, Wolfhalden, Switzerland). Based on the injection method, the grafts were divided into 2 groups: In group A (n = 10), a small air bubble was placed inside the graft roll while it was in the injector...
September 8, 2017: Cornea
https://www.readbyqxmd.com/read/28883661/visualizing-micro-anatomical-structures-of-the-posterior-cornea-with-micro-optical-coherence-tomography
#13
Si Chen, Xinyu Liu, Nanshuo Wang, Xianghong Wang, Qiaozhou Xiong, En Bo, Xiaojun Yu, Shufen Chen, Linbo Liu
Diagnosis of corneal disease and challenges in corneal transplantation require comprehensive understanding of corneal anatomy, particularly that of the posterior cornea. Micro-optical coherence tomography (µOCT) is a potentially suitable tool to meet this need, owing to its ultrahigh isotropic spatial resolution, high image acquisition rate and depth priority scanning mode. In this study, we explored the ability of µOCT to visualize micro-anatomical structures of the posterior cornea ex vivo and in vivo using small and large animals...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28872520/descemet-membrane-endothelial-keratoplasty-patch-for-persistent-corneal-hydrops
#14
Elmer Y Tu
PURPOSE: To report successful management of a case of persistent keratoconus-related hydrops with a Descemet membrane endothelial keratoplasty (DMEK) patch graft. METHODS: A case of corneal hydrops persisting for 7 months treated with DMEK was identified. The following information was collected: demographic data, surgical indications, clinical course, diagnostic tests, and clinical outcome. RESULTS: A 55-year-old patient with an established diagnosis of keratoconus was followed for 7 months without improvement in his acute corneal hydrops...
August 31, 2017: Cornea
https://www.readbyqxmd.com/read/28862260/a-paracentesis-to-save-time-and-money-with-re-bubbling-after-descemets-membrane-endothelial-keratoplasty
#15
F M Chew, K Teeluck, M A Nanavaty
No abstract text is available yet for this article.
September 1, 2017: Eye
https://www.readbyqxmd.com/read/28851322/portable-oct-assisted-surgical-treatment-of-intracorneal-pre-descemet-epithelial-cyst-a-case-report
#16
Sang Woo Kim, Eung Kweon Kim
BACKGROUND: Intracorneal epithelial cysts are a rare clinical condition that can occur anywhere in the corneal tissue; however, they appear most commonly in the stroma. They are sometimes challenging to treat because of their location, depth, and visual outcomes. Herein, we report a pre-Descemet epithelial cyst that was successfully treated surgically, with guidance from Fourier-domain optical coherence tomography (FD-OCT). CASE PRESENTATION: This interventional case report presents a patient with gradually decreasing vision caused by a pre-Descemet epithelial cyst...
August 29, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28844655/a-missed-diagnosis-of-multiple-intraocular-foreign-bodies-for-21-years
#17
Xubo Yang, Chunling Liu, Longqian Liu, Lanlan Zhang
A 30-year-old patient went to the emergency department because of a chemical burn to the left eye more than 10 days ago by toilet cleanser. Surprisingly, a small piece of glass was found in the inferior anterior chamber in the same eye. The visual acuity was counting fingers. There was conjunctival congestion, corneal oedema and Descemet's membrane striae. And there was also a corneal leukoma around 4 to 5 o'clock. Through repeated questioning he recalled that he was injured by an exploded light bulb around 21 years ago...
August 24, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28844326/-comparison-of-anatomic-and-functional-results-between-z6%C3%A2-femtosecond-laser-assisted-and-manual-trephination-in-deep-anterior-lamellar-keratoplasty-for-advanced-keratoconus-french-version
#18
A Blériot, E Martin, P Lebranchu, K Zimmerman, L Libeau, M Weber, B Vabres, I Orignac
The management of severe keratoconus requires corneal transplantation, for which the gold standard is deep anterior lamellar keratoplasty (DALK), preserving the healthy Descemet's membrane and endothelium. The safety and reproducibility of corneal cuts have been improved by the evolution of femtosecond lasers in refractive surgery, and femtosecond laser in DALK would seem to provide the same advantages over the manual method. In our retrospective study, we compare functional and anatomical results of femtosecond assisted DALK versus manual trephination DALK in patients with keratoconus in stage 4 of the Krumeich classification...
September 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28837528/minimizing-graft-preparation-failure-in-descemet-membrane-endothelial-keratoplasty
#19
Eitan Livny, Esther A Groeneveld-van Beek, Jessica T Lie, Kristin M Mangundap, Marieke Bruinsma, Rénuka S Birbal, Jacqueline van der Wees, Gerrit R J Melles
PURPOSE: To report the failure rate of 2 graft preparation techniques for Descemet membrane endothelial keratoplasty (DMEK) and to evaluate how to minimize graft preparation failure. METHODS: Retrospective, nonrandomized study at an eye bank specialized in graft preparation for lamellar keratoplasty. For 1416 donor corneas, the DMEK graft preparation failure rate was evaluated for 2 different techniques, technique I: "Standardized traditional technique" (n = 341) and technique II: "Standardized no-touch technique" (n = 933), and for grafts that were converted from technique II to technique I during preparation (n = 142)...
August 23, 2017: Cornea
https://www.readbyqxmd.com/read/28837527/prestained-and-preloaded-dmek-grafts-an-evaluation-of-tissue-quality-and-stain-retention
#20
Dorian A Zeidenweber, Khoa D Tran, Christopher S Sales, Stephen W Wehrer, Michael D Straiko, Mark A Terry
PURPOSE: To examine endothelial cell damage and stain retention of prestained preloaded Descemet membrane endothelial keratoplasty (DMEK) grafts. METHODS: DMEK grafts were stained with trypan blue or left unstained before loading into a Straiko modified Jones tube. A protocol to stain preloaded grafts inside the modified Jones tube and resulting cell loss was also examined. Endothelial cell loss was determined by vital dye staining after 3 days of cold storage and compared between the 3 groups...
August 23, 2017: Cornea
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