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Descemet's membrane

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https://www.readbyqxmd.com/read/29133660/predescemetocele-a-distinct-clinical-entity
#1
Priya Narang, Amar Agarwal, Dhivya Ashok Kumar
The case report incorporates a Fourier-domain optical coherence tomography (OCT) examination for demonstration of the existence of pre-Descemet's layer (PDL; Dua's layer) overlying a descemetocele and demonstrates predescemetocele as a separate clinical entity. The prospective analysis was done in two cases that had descemetocele, and OCT demonstrated the presence of PDL over an unruptured descemetocele that offers resilience and can be treated with an elective deep anterior lamellar keratoplasty or a penetrating keratoplasty...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29133296/comparison-of-preservation-and-transportation-protocols-for-preloaded-descemet-membrane-endothelial-keratoplasty
#2
Vito Romano, Mohit Parekh, Alessandro Ruzza, Colin E Willoughby, Stefano Ferrari, Diego Ponzin, Stephen B Kaye, Hannah J Levis
BACKGROUND/AIMS: Descemet membrane endothelial keratoplasty (DMEK) preparation is technically demanding and is a limiting factor for uptake of this kind of surgery. Supply methods that simplify the procedure for surgeons are key to increasing uptake. This study compares two different shipping protocols for DMEK. METHODS: An 8.5 mm DMEK graft was punched, marked and loaded for transportation in two different conditions: (A) endothelium trifolded inwards in organ culture conditions (n=7) and (B) endothelium rolled outwards in hypothermic conditions (n=7)...
November 13, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29120231/impact-of-clear-corneal-incision-morphology-on-incision-site-descemet-membrane-detachment-in-conventional-and-femtosecond-laser-assisted-phacoemulsification
#3
Jeewan S Titiyal, Manpreet Kaur, Priyanka Ramesh, Pooja Shah, Ruchita Falera, Lalit M S Bageshwar, Ashutosh Kinkar, Namrata Sharma
PURPOSE: To assess intraoperative morphology of clear corneal incisions (CCI) and its impact on incision-site descemet membrane detachment (DMD) in conventional phacoemulsification and femtosecond laser-assisted cataract surgery (FLACS). METHODS: Prospective comparative study of 129 eyes that underwent either conventional phacoemulsification (Group I, n = 77) or FLACS (Group II, n = 52) was undertaken at an apex tertiary care ophthalmic setup. In group I, a 2...
November 9, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29118505/descemet-s-membrane-macroperforation-during-interface-irrigation-in-big-bubble-deep-anterior-lamellar-keratoplasty
#4
Mohammed Ziaei, Susan E Ormonde
This report describes the macroperforation of descemet's membrane (DM) during irrigation of the interface following successful removal of stromal tissue in big bubble (BB) deep anterior lamellar keratoplasty (DALK). A 42-year-old woman with keratoconus underwent a BB DALK procedure. After successful formation of Type 2 bubble and removal of stromal tissue, interface irrigation was performed to remove residual viscoelastic. This led to a macroperforation of DM, and the case was converted to penetrating keratoplasty...
September 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29111821/correlations-of-corneal-optical-densitometry-endothelial-hexagonality-percentage-and-epithelium-thickness
#5
Gökhan Pekel, Fatih Özbakış, Alperen Bahar, Evre Pekel, Ebru Nevin Çetin
PURPOSE: Our aim was to examine the associations between the cornea morphological parameters, endothelial cell density, and anterior chamber measurements. METHODS: This observational study included 50 eyes of 50 healthy volunteers. The thicknesses of corneal epithelium, Bowman's layer, stroma, Descemet's membrane-endothelium complex, and pre-ocular tear film were measured by means of anterior segment optical coherence tomography. The keratometry (K), corneal volume (CV), corneal optical densitometry (COD), iridocorneal angle (ICA), anterior chamber depth (ACD), and anterior chamber volume (ACV) measurements were taken by the Scheimpflug anterior segment imaging...
November 7, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29111817/structural-ultrastructural-and-morphometric-study-of-the-zebrafish-ocular-surface-a-model-for-human-corneal-diseases
#6
Domenico Puzzolo, Antonina Pisani, Consuelo Malta, Giuseppe Santoro, Alessandro Meduri, Francesco Abbate, Giuseppe Montalbano, Edward Wylegala, Rosa Alba Rana, Fabio Bucchieri, Antonio Ieni, Pasquale Aragona, Antonio Micali
PURPOSE: A morphological and morphometric study of the adult zebrafish ocular surface was performed to provide a comprehensive description of its parts and to evaluate its similarity to the human. MATERIALS AND METHODS: The eyes of adult zebrafish were processed for light, transmission and scanning electron microscopy, and for immunohistochemical stain of corneal nerves; a morphometric analysis was also performed on several morphological parameters. RESULTS: The corneal epithelium was formed by five layers of cells...
November 7, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29111586/an-unusual-case-of-feline-acute-corneal-hydrops-atypical-disease-presentation-and-possible-in%C3%A2-vivo-detection-of-descemet-s-membrane-detachment-in-the-cat-s-unaffected-eye
#7
Brittany N Schlesener, Erin M Scott, Lucien V Vallone
A 1-year-old, female spayed, domestic shorthair cat presented for blepharospasm of the right eye. Slit-lamp biomicroscopic examination showed focal corneal ulceration and presumptive keratomalacia of the right eye. Examination of the left eye was normal apart from a focal endothelial opacity. Within the first 24 h of medical management, the right eye developed marked corneal edema and globular anterior protrusion of the corneal surface consistent with feline acute corneal hydrops (FACH). Surgical management consisted of a bridge conjunctival graft, nictitating membrane flap, and temporary tarsorrhaphy...
November 7, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29095752/double-docking-technique-for-femtosecond-laser-assisted-deep-anterior-lamellar-keratoplasty
#8
Damien Guindolet, Diem T Nguyen, Ciara Bergin, Serge Doan, Isabelle Cochereau, Eric E Gabison
PURPOSE: To describe a new and safe surgical technique of deep anterior lamellar keratoplasty (DALK) using the femtosecond laser (FSL) and intraoperative optical coherence tomography (iOCT) for surgical management of corneal thinning and/or opacities. The technique was coined the double-docking procedure for DALK (DD-DALK). METHODS: FSL-integrated iOCT was used for direct visualization and calibration to perform precise anterior lamellar and side cuts for the removal of the anterior stroma...
October 31, 2017: Cornea
https://www.readbyqxmd.com/read/29089772/isolated-descemetorhexis-for-anterior-synechiolysis-prior-to-endothelial-keratoplasty-case-report-and-technique
#9
Konstantinos Droutsas, Konstantinos Andreanos, Apostolos Lazaridis, Ilias Georgalas, George Kymionis, Dimitris Papaconstantinou
PURPOSE: To describe the utilization of descemetorhexis for reformation of the anterior chamber in eyes with central iridocorneal synechiae before endothelial keratoplasty (EK). METHODS: A 71-year-old man with a history of trabeculectomy complicated by hypotony presented with bullous keratopathy in the presence of extensive iridocorneal synechiae and a flat anterior chamber. In order to proceed with EK, synechiolysis with the use of viscoelastic and scissors was attempted...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29066773/biomechanical-simulation-of-stress-concentration-and-intraocular-pressure-in-corneas-subjected-to-myopic-refractive-surgical-procedures
#10
Po-Jen Shih, I-Jong Wang, Wen-Feng Cai, Jia-Yush Yen
Recent advances in the analysis of corneal biomechanical properties remain difficult to predict the structural stability before and after refractive surgery. In this regard, we applied the finite element method (FEM) to determine the roles of the Bowman's membrane, stroma, and Descemet's membrane in the hoop stresses of cornea, under tension (physiological) and bending (nonphysiological), for patients who undergo radial keratotomy (RK), photorefractive keratectomy (PRK), laser-assisted in situ keratomileusis (LASIK), or small incision lenticule extraction (SMILE)...
October 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29066651/rescuing-the-host-descemet-s-membrane-in-full-thickness-traumatic-wound-dehiscence-in-deep-anterior-lamellar-keratoplasty-intraoperative-optical-coherence-tomography-ioct-guided-technique
#11
Manthan Hasmukhbhai Chaniyara, Rahul Bafna, Jayanand Urkude, Namrata Sharma
Optimal visual recovery following full-thickness traumatic wound dehiscence in a case of operated deep anterior lamellar keratoplasty (DALK) is rarely seen. Here we report a case of 22-year-old male patient presented to our casualty department with complaint of sudden-onset diminution of vision in his right eye following blunt trauma of 1 day duration. DALK had been performed 11 months ago for advanced keratoconus in the same eye. Best-corrected visual acuity (BCVA) in the right eye was hand movement close to face with accurate projection of rays and in the left eye was 20/20...
October 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29053561/recognizing-and-managing-bullous-descemet-detachment-secondary-to-accidental-hydroseparation-during-phacoemulsification-cataract-surgery-by-relaxing-descemetotomy
#12
Soosan Jacob, Amar Agarwal, Athiya Agarwal, Saijimol Ai
PURPOSE: To report a new technique called relaxing Descemetotomy for treatment of bullous Descemet detachment (BDD) secondary to accidental hydroseparation of Descemet membrane (DM) during stromal hydration in cataract surgery. METHODS: A clear corneal keratome entry was created close to the limbus extending inward to create a relaxing cut (ab externo relaxing Descemetotomy) on taut DM, thus creating an egress route for supra-Descemetic fluid (SDF). This was followed by pneumodescemetopexy to drain SDF internally...
October 17, 2017: Cornea
https://www.readbyqxmd.com/read/29051516/stromal-striae-a-new-insight-into-corneal-physiology-and-mechanics
#13
Kate Grieve, Djida Ghoubay, Cristina Georgeon, Gael Latour, Amir Nahas, Karsten Plamann, Caroline Crotti, Romain Bocheux, Marie Borderie, Thu-Mai Nguyen, Felipe Andreiuolo, Marie-Claire Schanne-Klein, Vincent Borderie
We uncover the significance of a previously unappreciated structural feature in corneal stroma, important to its biomechanics. Vogt striae are a known clinical indicator of keratoconus, and consist of dark, vertical lines crossing the corneal depth. However we detected stromal striae in most corneas, not only keratoconus. We observed striae with multiple imaging modalities in 82% of 118 human corneas, with pathology-specific differences. Striae generally depart from anchor points at Descemet's membrane in the posterior stroma obliquely in a V-shape, whereas in keratoconus, striae depart vertically from posterior toward anterior stroma...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29045313/importance-of-axial-length-and-functional-corneal-endothelial-cells-in-descemet-membrane-endothelial-keratoplasty
#14
Davide Borroni, Melanie Ferronato, Zita Krumina, Mohit Parekh
No abstract text is available yet for this article.
December 2017: Cornea
https://www.readbyqxmd.com/read/29043524/improving-the-success-rate-of-human-corneal-endothelial-cell-cultures-from-single-donor-corneas-with-stabilization-medium
#15
D Spinozzi, A Miron, M Bruinsma, J T Lie, I Dapena, S Oellerich, G R J Melles
Main objective of this study was to improve the success rate of human corneal endothelial cell (hCEC) cultures from single donor corneas. We could show that the use of stabilization medium prior to cell isolation may have a positive effect on the success rate of hCEC cultures from single research-grade donor corneas by allowing growth of otherwise possibly not successful cultures and by improving their proliferative rate. hCEC were obtained from corneo-scleral rims of 7 discarded human research-grade cornea pairs...
October 17, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/29040116/air-versus-sulfur-hexafluoride-gas-tamponade-in-descemet-membrane-endothelial-keratoplasty-a-fellow-eye-comparison
#16
Philipp V von Marchtaler, Julia M Weller, Friedrich E Kruse, Theofilos Tourtas
PURPOSE: To perform a fellow eye comparison of outcomes and complications when using air or sulfur hexafluoride (SF6) gas as a tamponade in Descemet membrane endothelial keratoplasty (DMEK). METHODS: One hundred thirty-six eyes of 68 consecutive patients who underwent uneventful DMEK in both eyes for Fuchs endothelial corneal dystrophy were included in this retrospective study. Inclusion criteria were air tamponade (80% of the anterior chamber volume) in the first eye and 20% SF6 gas tamponade (80% of the anterior chamber volume) in the second eye; and same donor tissue culture condition in both eyes...
October 13, 2017: Cornea
https://www.readbyqxmd.com/read/29034411/impact-of-corneal-donor-lens-status-on-two-year-course-and-outcome-of-descemet-membrane-endothelial-keratoplasty-dmek
#17
Friederike Schaub, Layla Pohl, Philip Enders, Werner Adler, Björn O Bachmann, Claus Cursiefen, Ludwig M Heindl
PURPOSE: Our purpose was to investigate the impact of lens status of corneal donors on the two-year course and clinical outcome of Descemet membrane endothelial keratoplasty (DMEK). METHODS: In 181 DMEK surgeries, 136 phakic and 45 pseudophakic donor corneas were grafted. In this retrospective audit we compared the lens status of corneal donors regarding the outcome measures best spectacle-corrected visual acuity (BSCVA), central corneal thickness (CCT), and endothelial cell density (ECD) at 1, 3, 6, 12, and 24 months, as well as intra- and postoperative complication rates and graft detachment rates requiring re-bubbling...
October 15, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29023312/prediction-of-descemet-membrane-perforation-during-deep-anterior-lamellar-keratoplasty-in-patients-with-keratoconus-with-stromal-scar
#18
Mehmet Cuneyt Ozmen, Nilufer Yesilirmak, Bahri Aydin, Kubra Serbest Ceylanoglu, Hatice Tuba Atalay, Fikret Akata
OBJECTIVES: To report big-bubble deep anterior lamellar keratoplasty (DALK) in patients with keratoconus with corneal stromal scar, and to investigate factors that can influence intraoperative Descemet membrane (DM) perforation. METHODS: A retrospective study included patients with keratoconus with central stromal scar that underwent DALK using the big-bubble technique. Best spectacle-corrected visual acuity (BSCVA), keratometry, minimum corneal thickness (MCT), stromal scar depth, and endothelial cell density (ECD) were recorded...
October 11, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28991851/quantitative-analysis-of-endothelial-cell-loss-in-preloaded-descemet-membrane-endothelial-keratoplasty-grafts
#19
Meraf A Wolle, David L DeMill, Lauren Johnson, Stephen I Lentz, Maria A Woodward, Shahzad I Mian
PURPOSE: Availability of preloaded Descemet membrane endothelial keratoplasty (pDMEK) tissue may increase acceptance of DMEK in surgical management of endothelial disease. The goal of this study was to determine the safety of pDMEK grafts for 24 hours before surgery by analyzing endothelial cell loss (ECL) using 2 image analysis software programs. METHODS: A total of 18 cadaveric corneas were prepared for DMEK using a standardized technique and loaded in a modified Jones tube injector...
November 2017: Cornea
https://www.readbyqxmd.com/read/28990995/donor-tissue-preparation-for-descemet-membrane-endothelial-keratoplasty-an-updated-review
#20
Rénuka S Birbal, Shameema Sikder, Jessica T Lie, Esther A Groeneveld-van Beek, Silke Oellerich, Gerrit R J Melles
PURPOSE: To provide an overview of the current literature on donor tissue preparation for Descemet membrane endothelial keratoplasty (DMEK). METHODS: A comprehensive database search without date restrictions was performed in PubMed and in The Cochrane Library in May, 2017. Keywords included Descemet membrane endothelial keratoplasty, corneal transplantation, graft, harvest, dissection, preparation, endothelial cell, and endothelial cell density. Articles aiming to describe or evaluate a technique for DMEK graft preparation were considered eligible and were included in this review...
October 5, 2017: Cornea
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