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Innate lymphoid type 2 cells

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https://www.readbyqxmd.com/read/29788271/the-innate-immune-system-in-the-gastrointestinal-tract-role-of-intraepithelial-lymphocytes-and-lamina-propria-innate-lymphoid-cells-in-intestinal-inflammation
#1
A Montalban-Arques, M Chaparro, Javier P Gisbert, D Bernardo
Background: The gastrointestinal tract harbors the largest microbiota load in the human body, hence maintaining a delicate balance between immunity against invading pathogens and tolerance toward commensal. Such immune equilibrium, or intestinal homeostasis, is conducted by a tight regulation and cooperation of the different branches of the immune system, including the innate and the adaptive immune system. However, several factors affect this delicate equilibrium, ultimately leading to gastrointestinal disorders including inflammatory bowel disease...
May 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29764019/-the-role-of-type-2-innate-lymphoid-cells-in-the-pathogenesis-of-eosinophilic-chronic-rhinosinusitis-with-nasal-polyps
#2
C L Geng, Z M Xing, L S Yu, M Wang, X P Yuan, Y Liu, G Zhang, Z J Wang
Objective: To investigate the type 2 innate lymphoid cells (ILC2s) in eosinophilic nasal polyps, non-eosinophilic nasal polyps and controls, and to compare the characteristics of ILC2s indifferent types of nasal polyp. Methods: Flow cytometric analysis was used to quantify the ILC2s and Th2 cells in tissues from 19 patients with chronic rhinosinusitis with nasal polyp (CRSwNP) and 6 controls. The patients were classified into two groups as eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) and non-eosinophilic chronic rhinosinusitis with nasal polyps (non-ECRSwNP) based on eosinophil counts under hematoxylin-eosin staining...
May 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29762870/t-cells-and-ilc2s-are-major-effector-cells-in-influenza-induced-exacerbation-of-allergic-airway-inflammation-in-mice
#3
Bobby W S Li, Marjolein J W de Bruijn, Melanie Lukkes, Menno van Nimwegen, Ingrid M Bergen, Alex KleinJan, Corine H GeurtsvanKessel, Arno Andeweg, Guus F Rimmelzwaan, Rudi W Hendriks
Influenza virus infection is an important cause of severe asthma exacerbations, but it remains unclear how a Th1-mediated antiviral response triggers a prototypical Th2 disease. We investigated CD4+ T cells and group 2 innate lymphoid cells (ILC2s) in influenza virus-infected mice. We found that ILC2s accumulated in the lung rapidly after influenza virus infection, but the induction of IL-5 and IL-13 secretion was delayed and concomitant with T cell activation. In an influenza-induced exacerbation of allergic airway inflammation model we noticed an initial reduction of ILC2 numbers and cytokine production in broncho-alveolar lavage compared to chronic house dust mite (HDM)-mediated airway inflammation alone...
May 15, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29760695/group-2-innate-lymphoid-cells-in-pulmonary-immunity-and-tissue-homeostasis
#4
REVIEW
Barbara C Mindt, Jörg H Fritz, Claudia U Duerr
Group 2 innate lymphoid cells (ILC2) represent an evolutionary rather old but only recently identified member of the family of innate lymphoid cells and have received much attention since their detailed description in 2010. They can orchestrate innate as well as adaptive immune responses as they interact with and influence several immune and non-immune cell populations. Moreover, ILC2 are able to rapidly secrete large amounts of type 2 cytokines that can contribute to protective but also detrimental host immune responses depending on timing, location, and physiological context...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29760540/ambiguous-roles-of-innate-lymphoid-cells-in-chronic-development-of-liver-diseases
#5
REVIEW
Yue Shen, Jing Li, Si-Qi Wang, Wei Jiang
Innate lymphoid cells (ILCs) are defined as a distinct arm of innate immunity. According to their profile of secreted cytokines and lineage-specific transcriptional factors, ILCs can be categorized into the following three groups: group 1 ILCs (including natural killer (NK) cells and ILC1s) are dependent on T-bet and can produce interferon-γ; group 2 ILCs (ILC2s) are dependent on GATA3 and can produce type 2 cytokines, including interleukin (IL)-5 and IL-13; and, group 3 ILCs (including lymphoid tissue-like cells and ILC3s) are dependent on RORγt and can produce IL-22 and IL-17...
May 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29742315/solitary-chemosensory-cells-producing-interleukin-25-and-group-2-innate-lymphoid-cells-are-enriched-in-chronic-rhinosinusitis-with-nasal-polyps
#6
Neil N Patel, Michael A Kohanski, Ivy W Maina, Vasiliki Triantafillou, Alan D Workman, Charles C L Tong, Edward C Kuan, John V Bosso, Nithin D Adappa, James N Palmer, De'Broski R Herbert, Noam A Cohen
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is commonly characterized by type-2 inflammation. It is established that group-2 innate lymphoid cells (ILC2s) are a subset of immune cells important in orchestrating mucosal type-2 response. IL-25 is an epithelial-derived cytokine that is a critical activator of ILC2s. Recent evidence demonstrates that specialized taster epithelial cells, such as solitary chemosensory cells (SCCs), may be producers of IL-25. To elucidate the relationship between SCCs and ILC2s in CRSwNP, we sought to quantify ILC2s and SCCs to determine if these cell types are enriched in nasal polyps compared to healthy sinonasal mucosa...
May 9, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29740438/the-nkg2d-nkg2dl-axis-in-the-crosstalk-between-lymphoid-and-myeloid-cells-in-health-and-disease
#7
REVIEW
Ana Stojanovic, Margareta P Correia, Adelheid Cerwenka
Natural killer group 2, member D (NKG2D) receptor is a type II transmembrane protein expressed by both innate and adaptive immune cells, including natural killer (NK) cells, CD8+ T cells, invariant NKT cells, γδ T cells, and some CD4+ T cells under certain pathological conditions. NKG2D is an activating NK receptor that induces cytotoxicity and production of cytokines by effector cells and supports their proliferation and survival upon engagement with its ligands. In both innate and T cell populations, NKG2D can costimulate responses induced by other receptors, such as TCR in T cells or NKp46 in NK cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29732233/pathogenesis-of-recalcitrant-chronic-rhinosinusitis-the-emerging-role-of-innate-immune-cells
#8
REVIEW
Il Gyu Kong, Dae Woo Kim
Chronic rhinosinusitis (CRS) is a major part of the recalcitrant inflammatory diseases of the upper airway that needs enormous socioeconomic burden. T helper (Th) 2 type immune responses recruiting eosinophils were the most well-known immune players in CRS pathogenesis especially in western countries. By the piling up of a vast amount of researches to elucidate the pathogenic mechanism of CRS recently, heterogeneous inflammatory processes were found to be related to the phenotypes of CRS. Recently more cells other than T cells were in the focus of CRS pathogenesis, such as the epithelial cell, macrophage, innate lymphoid cells, and neutrophils...
April 2018: Immune Network
https://www.readbyqxmd.com/read/29726984/immune-cell-census-in-murine-atherosclerosis-cytometry-by-time-of-flight-illuminates-vascular-myeloid-cell-diversity
#9
Jennifer E Cole, Inhye Park, David Ahern, Christina Kassiteridi, Dina Danso Abeam, Michael Goddard, Patricia Green, Pasquale Maffia, Claudia Monaco
Aims: Atherosclerosis is characterised by the abundant infiltration of myeloid cells starting at early stages of disease. Myeloid cells are key players in vascular immunity during atherogenesis. However, the subsets of vascular myeloid cells have eluded resolution due to shared marker expression and atypical heterogeneity in vascular tissues. We applied the high-dimensionality of mass cytometry to the study of myeloid cell subsets in atherosclerosis. Methods and Results: Apolipoprotein E-deficient (ApoE-/-) mice were fed a chow or a high fat (western) diet for 12 weeks...
May 2, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29722022/an-st2-dependent-role-of-bone-marrow-derived-group-2-innate-lymphoid-cells-in-pulmonary-fibrosis
#10
Yuyue Zhao, Francina Gonzalez De Los Santos, Zhe Wu, Tianju Liu, Sem H Phan
Recent evidence supports that bone marrow (BM)-derived hematopoietic progenitor cells play an important role in lung injury and fibrosis. While these cells give rise to multiple cell types, the ST2 (Il1rl1)-expressing group 2 innate lymphoid cells (ILC2) derived from BM progenitors have been implicated in tissue repair and remodeling, including in lung fibrosis. To further investigate the precise role of BM-derived ILC2 in the pathogenesis of fibrotic lung disease their importance in the bleomycin-induced lung fibrosis model was evaluated by analyzing the effects of selective ST2 deficiency in the BM compartment...
May 3, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29719233/toward-an-understanding-of-how-immune-cells-control-brown-and-beige-adipobiology
#11
REVIEW
Francesc Villarroya, Rubén Cereijo, Joan Villarroya, Aleix Gavaldà-Navarro, Marta Giralt
Immune cells were recently found to have an unexpected involvement in controlling the thermogenic activity of brown and beige adipose tissue. Here, we review how macrophages, eosinophils, type 2 innate lymphoid cells, and T lymphocytes are linked to this process. In particular, the recruitment of alternatively activated macrophages and eosinophils is associated with brown fat activation and white fat browning. Conversely, pro-inflammatory immune cell recruitment represses the thermogenic activity of brown and beige adipose tissues via cytokines that inhibit noradrenergic signaling...
May 1, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29672927/interleukin-33-contributes-to-ilc2-activation-and-early-inflammation-associated-lung-injury-during-abdominal-sepsis
#12
Hui Xu, Jing Xu, Li Xu, Shuqing Jin, Heth R Turnquist, Rosemary Hoffman, Patricia Loughran, Timothy R Billiar, Meihong Deng
Sepsis is defined as infection with organ dysfunction due to a dysregulated immune response. The lung is one of the most vulnerable organs at the onset of sepsis. Interleukin-33 (IL-33) can be released by injured epithelial and endothelial cells in the lung and regulate immune activation and infiltration. Therefore, we postulated that IL-33 would contribute to the immune response in the lung during sepsis. Using the cecal ligation and puncture (CLP) sepsis model, we show here that IL-33 contributes significantly to both sepsis-induced inflammation in the lung and systemic inflammatory response in the early phase of sepsis...
April 19, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29645082/soluble-st2-sst2-regulation-by-rhinovirus-rv-and-25-oh-vitamin-d3-in-the-blood-of-asthmatic-children
#13
Patricia Haag, Himanshu Sharma, Manfred Rauh, Theodor Zimmermann, Tytti Vuorinen, Nikolaos G Papadopoulos, Scott T Weiss, Susetta Finotto
Paediatric asthma exacerbations are often caused by Rhinovirus (RV). Moreover, 25(OH)-Vitamin D3 (=25(OH) VitD3) deficiency during infancy was found associated with asthma. Here, we investigated the innate immune responses to RV and their possible modulation by 25(OH) VitD3 serum levels in a preschool cohort of children with and without asthma. The innate lymphoid cell type 2 (ILC2)-associated marker, ST2 was found upregulated in the blood cells of asthmatic children with low serum levels of 25(OH)VitD3 in the absence of RV in their airways...
April 12, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29626211/targeting-cytokines-to-treat-asthma-and-chronic-obstructive-pulmonary-disease
#14
REVIEW
Peter J Barnes
Cytokines play a key role in orchestrating and perpetuating the chronic airway inflammation in asthma and chronic obstructive pulmonary disease (COPD), making them attractive targets for treating these disorders. Asthma and some cases of COPD are mainly driven by type 2 immune responses, which comprise increased airway eosinophils, T helper 2 (TH 2) cells and group 2 innate lymphoid cells (ILC2s) and the secretion of IL-4, IL-5 and IL-13. Clinical trials of antibodies that block these interleukins have shown reduced acute exacerbations and oral corticosteroid use and improvements in lung function and symptoms in selected patients...
April 6, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29625134/il-17-producing-st2-ilc2-plays-a-pathogenic-role-in-lung-inflammation
#15
Ting Cai, Jinxin Qiu, Yan Ji, Wenjing Li, Zhaoyun Ding, Caixia Suo, Jiali Chang, Jingjing Wang, Rui He, Youcun Qian, Xiaohuan Guo, Liang Zhou, Huiming Sheng, Lei Shen, Ju Qiu
BACKGROUND: IL-17 plays a pathogenic role in asthma. ST2- iILC2s (inflammatory group 2 innate lymphoid cells) driven by IL-25 can produce IL-17, while ST2+ nILC2s (natural ILC2s) produce few IL-17. OBJECTIVE: We characterized the ST2+ IL-17+ ILC2s during lung inflammation and determined the pathogenesis and molecular regulation of ST2+ IL-17+ ILC2s. METHODS: Lung inflammation was induced by papain or IL-33. IL-17 production by lung ILC2s from wild-type, Rag1-/- , Rorcgfp/gfp and Ahr-/- mice was examined by flow cytometry...
April 3, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29623414/ilc2s-in-infectious-diseases-and-organ-specific-fibrosis
#16
REVIEW
Markus Kindermann, Lisa Knipfer, Imke Atreya, Stefan Wirtz
Type 2 immune responses evolved to provide host protection against parasitic infections and to support the repair of infection-induced tissue injury. However, persistent chronic organ damage can result in dysregulated production of critical type 2 cytokines supporting tissue remodeling and fibrosis development. Recently, group 2 innate lymphoid cells (ILC2s) were newly described as central innate mediators of type 2 responses. In particular, by secretion of the cytokines IL-5, IL-9, and IL-13 and the growth factor amphiregulin in response to the release of tissue-derived alarmins, ILC2s have been shown to substantially contribute to both the dismissal of metazoan parasites and the repair of infection-dependent or sterile tissue damage...
March 26, 2018: Seminars in Immunopathology
https://www.readbyqxmd.com/read/29599193/pulmonary-neuroendocrine-cells-amplify-allergic-asthma-responses
#17
Pengfei Sui, Darin L Wiesner, Jinhao Xu, Yan Zhang, Jinwoo Lee, Steven Van Dyken, Amber Lashua, Chuyue Yu, Bruce S Klein, Richard M Locksley, Gail Deutsch, Xin Sun
Pulmonary neuroendocrine cells (PNECs) are rare airway epithelial cells whose function is poorly understood. Here we show that Ascl1 -mutant mice which have no PNECs exhibit severely blunted mucosal type 2 response in models of allergic asthma. PNECs reside in close proximity to group 2 innate lymphoid cells (ILC2s) near airway branch points. PNECs act through calcitonin gene-related peptide (CGRP) to stimulate ILC2s and elicit downstream immune responses. In addition, PNECs act through neurotransmitter gamma-aminobutyric acid (GABA) to induce goblet-cell hyperplasia...
March 29, 2018: Science
https://www.readbyqxmd.com/read/29593738/prostaglandin-e-2-inhibits-group-2-innate-lymphoid-cell-activation-and-allergic-airway-inflammation-through-e-prostanoid-4-cyclic-adenosine-monophosphate-signaling
#18
Yu Zhou, Wei Wang, Conghui Zhao, Yan Wang, Haoming Wu, Xiuyuan Sun, Youfei Guan, Yu Zhang
Evidence is accumulating that group 2 innate lymphoid cells (ILC2) play an important role in allergic airway inflammation by producing a large amount of type 2 cytokines. But it remains poorly understood how its activities are properly controlled in vivo . Here, we demonstrated that prostaglandin E2 (PGE2 ) had a profound inhibitory effect on IL-33-induced ILC2 expansion and IL-5 and IL-13 production in vitro . This effect was mimicked by PGE1 -alcohol but attenuated by ONO-AE3-208, indicating a selective action through the E-prostanoid 4 (EP4) receptor...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29593546/commentary-neuronal-regulation-of-type-2-innate-lymphoid-cells-via-neuromedin-u
#19
COMMENT
Geraldine M Jowett, Joana F Neves
No abstract text is available yet for this article.
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29569854/il-25-axis-is-involved-in-the-pathogenesis-of-human-primary-and-experimental-sj%C3%A3-gren-s-syndrome
#20
Giuliana Guggino, Xiang Lin, Aroldo Rizzo, Fan Xiao, Laura Saieva, Stefania Raimondo, Diana Di Liberto, Giuseppina Candore, Piero Ruscitti, Paola Cipriani, Roberto Giacomelli, Francesco Dieli, Riccardo Alessandro, Giovanni Triolo, Liwei Lu, Francesco Ciccia
OBJECTIVE: To investigate the role of IL-25/IL-17RB axis in experimental Sjögren's syndrome (ESS) and in patients with primary Sjögren Syndrome (pSS) and pSS-associated lymphoma. METHODS: Expression of IL-25, IL-17RB, IL-17B and TRAF6 was analyzed on minor salivary glands (MSG) from pSS patients and on parotid glands from pSS-associated B cell non-Hodgkin lymphomas (NHL). IL-17RB expression and the frequencies of natural type 2 innate lymphoid cells (nILC2), inflammatory ILC2 (iILC2) and M2-polarized macrophages were assessed by flow cytometry in salivary gland mononuclear cells (SGMC) and peripheral blood mononuclear cells (PBMC)...
March 23, 2018: Arthritis & Rheumatology
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