keyword
https://read.qxmd.com/read/38535201/gut-mycobiome-and-asthma
#1
REVIEW
Amjad N Kanj, Joseph H Skalski
This review explores the 'gut-lung axis' in asthma with a focus on commensal fungal organisms. We explore how changes to the intestinal commensal fungal community composition alter lung immune function. We comprehensively review available studies that have profiled the composition of the gut mycobiome in adults and children with asthma, and discuss mechanisms of gut-lung interactions that have been described in animal models of asthma. Studies indicate that intestinal fungal dysbiosis, such as an increased abundance of certain fungi like Candida , can elevate the risk of asthma in children and exacerbate it in adults...
March 1, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38530239/piezo1-channels-restrain-ilc2s-and-regulate-the-development-of-airway-hyperreactivity
#2
JOURNAL ARTICLE
Benjamin P Hurrell, Stephen Shen, Xin Li, Yoshihiro Sakano, Mohammad Hossein Kazemi, Christine Quach, Pedram Shafiei-Jahani, Kei Sakano, Homayon Ghiasi, Omid Akbari
Mechanosensitive ion channels sense force and pressure in immune cells to drive the inflammatory response in highly mechanical organs. Here, we report that Piezo1 channels repress group 2 innate lymphoid cell (ILC2)-driven type 2 inflammation in the lungs. Piezo1 is induced on lung ILC2s upon activation, as genetic ablation of Piezo1 in ILC2s increases their function and exacerbates the development of airway hyperreactivity (AHR). Conversely, Piezo1 agonist Yoda1 reduces ILC2-driven lung inflammation. Mechanistically, Yoda1 inhibits ILC2 cytokine secretion and proliferation in a KLF2-dependent manner, as we found that Piezo1 engagement reduces ILC2 oxidative metabolism...
May 6, 2024: Journal of Experimental Medicine
https://read.qxmd.com/read/38530054/microbiota-from-human-infants-consuming-secretors-or-non-secretors-mothers-milk-impacts-the-gut-and-immune-system-in-mice
#3
JOURNAL ARTICLE
Manoj Gurung, Brent Thomas Schlegel, Dhivyaa Rajasundaram, Renee Fox, Lars Bode, Tianming Yao, Stephen R Lindemann, Tanya LeRoith, Quentin D Read, Christy Simecka, Laura Carroll, Aline Andres, Laxmi Yeruva
UNLABELLED: Maternal secretor status is one of the determinants of human milk oligosaccharides (HMOs) composition, which, in turn, influences the gut microbiota composition of infants. To understand if this change in gut microbiota impacts immune cell composition, intestinal morphology, and gene expression, 21-day-old germ-free C57BL/6 mice were transplanted with fecal microbiota from infants whose mothers were either secretors (SMM) or non-secretors (NSM) or from infants consuming dairy-based formula (MFM)...
March 26, 2024: MSystems
https://read.qxmd.com/read/38524132/a-novel-type-2-innate-lymphoid-cell-based-immunotherapy-for-cancer
#4
JOURNAL ARTICLE
Iryna Saranchova, Clara Wenjing Xia, Stephanie Besoiu, Pablo L Finkel, Samantha L S Ellis, Suresh Kari, Lonna Munro, Cheryl G Pfeifer, Ladan Fazli, Martin E Gleave, Wilfred A Jefferies
Cell-based cancer immunotherapy has achieved significant advancements, providing a source of hope for cancer patients. Notwithstanding the considerable progress in cell-based immunotherapy, the persistently low response rates and the exorbitant costs associated with their implementation still present a formidable challenge in clinical settings. In the landscape of cell-based cancer immunotherapies, an uncharted territory involves Type 2 innate lymphoid cells (ILC2s) and interleukin-33 (IL-33) which promotes ILC2 functionality, recognized for their inherent ability to enhance immune responses...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38516928/roles-of-il-4-il-13-and-their-receptors-in-lung-cancer
#5
REVIEW
Yao Zhang, Kangle Zhu, Xiao Wang, Yi Zhao, Jingwei Shi, Zhengcheng Liu
Interleukin (IL)-4 and IL-13 are the main effectors of innate lymphoid cells (ILC2) of the type 2 innate immune response, which can carry out specific signal transmission between multiple cells in the tumor immune microenvironment. IL-4 and IL-13 mediate signal transduction and regulate cellular functions in a variety of solid tumors through their shared receptor chain, the transmembrane heterodimer interleukin-4 receptor alpha/interleukin-13 receptor alpha-1 (type II IL-4 receptor). IL-4, IL-13, and their receptors can induce the formation of a variety of malignant tumors and play an important role in their progression, growth, and tumor immunity...
March 22, 2024: Journal of Interferon & Cytokine Research
https://read.qxmd.com/read/38513576/ilc2s-unraveling-the-innate-immune-orchestrators-in-allergic-inflammation
#6
REVIEW
Hui-Fei Lu, Yi-Chi Zhou, Dan-Dan Luo, Dun-Hui Yang, Xi-Jia Wang, Bao-Hui Cheng, Xian-Hai Zeng
The prevalence rate of allergic diseases including asthma, atopic rhinitis (AR) and atopic dermatitis (AD) has been significantly increasing in recent decades due to environmental changes and social developments. With the study of innate lymphoid cells, the crucial role played by type 2 innate lymphoid cells (ILC2s) have been progressively unveiled in allergic diseases. ILC2s, which are a subset of innate lymphocytes initiate allergic responses. They respond swiftly during the onset of allergic reactions and produce type 2 cytokines, working in conjunction with T helper type 2 (Th2) cells to induce and sustain type 2 immune responses...
March 19, 2024: International Immunopharmacology
https://read.qxmd.com/read/38506432/new-insights-into-ilc2-memory
#7
REVIEW
Itziar Martinez-Gonzalez, Fumio Takei
Group 2 Innate Lymphoid Cells (ILC2s) are innate lymphocytes involved in type 2 immunity. ILC2s are abundant at the barrier tissues and upon allergen exposure, respond to epithelial-derived alarmins by producing type 2 cytokines (e.g., IL-5 and IL-13). Upon activation, some of these activated ILC2s acquire immunological memory and can mount enhanced responses upon further allergen encounters. Here, we review recent findings of the cellular and molecular mechanisms underlying immune memory in ILC2s both in mice and humans and discuss the implications of memory ILC2s in the context of allergic diseases...
March 20, 2024: Immunological Reviews
https://read.qxmd.com/read/38502310/single-cell-analysis-of-age-related-changes-in-leukocytes-of-diabetic-mouse-hindpaws
#8
JOURNAL ARTICLE
James M Nichols, Hoang Vu Pham, Eric F Lee, Rajasekaran Mahalingam, Andrew J Shepherd
Complications associated with Type 1 and Type 2 diabetes, such as diabetic peripheral neuropathy and diabetic foot ulcers, are a growing health-care concern. In addition, this concern increases as diabetic patients age due to their increased susceptibility to complications. To address this growing problem, it is important to understand fluctuations in physiology which lead to pathological changes associated with the metabolic disturbances of diabetes. Our study explores dysregulation of immune cell populations in the hindpaws of healthy and diabetic mice at 12 and 21 weeks of age using single-cell RNA sequencing to provide insight into immune disruptions occurring in the distal limb during chronic diabetes...
March 19, 2024: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/38501542/obesity-correlates-with-the-immunosuppressive-ilc2s-mdscs-axis-in-advanced-breast-cancer
#9
JOURNAL ARTICLE
Wei Liu, Bingyu Li, Dan Liu, Bing Zhao, Gang Sun, Jianbing Ding
AIM: We investigated the relationship between the group 2 innate lymphoid cells (ILC2s)-myeloid-derived suppressor cells (MDSCs) axis and obesity-related breast cancer. METHODS: Fifty-eight patients with breast cancer who had first relapse and metastasis between January 2019 and August 2021 were enrolled. The proportions of ILC2s and MDSCs in blood and the levels of cytokines in serum were detected with flow cytometry. Correlation analysis among clinical characteristics (such as body mass index [BMI]), cytokines, ILC2s, and MDSCs was conducted...
March 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38474426/communication-between-mast-cells-and-group-2-innate-lymphoid-cells-in-the-skin
#10
REVIEW
Yeganeh Mehrani, Solmaz Morovati, Tahmineh Tajik, Soroush Sarmadi, Ali Bitaraf, Zahra Sourani, Mohammad Shahverdi, Helia Javadi, Julia E Kakish, Byram W Bridle, Khalil Karimi
The skin is a dynamic organ with a complex immune network critical for maintaining balance and defending against various pathogens. Different types of cells in the skin, such as mast cells (MCs) and group 2 innate lymphoid cells (ILC2s), contribute to immune regulation and play essential roles in the early immune response to various triggers, including allergens. It is beneficial to dissect cell-to-cell interactions in the skin to elucidate the mechanisms underlying skin immunity. The current manuscript concentrates explicitly on the communication pathways between MCs and ILC2s in the skin, highlighting their ability to regulate immune responses, inflammation, and tissue repair...
March 6, 2024: Cells
https://read.qxmd.com/read/38469889/improvement-of-hepatic-innate-immunity-in-chemically-injured-livers-to-develop-hepatocarcinoma-by-a-serine-type-protease-inhibitors-enriched-extract-from-chenopodium-quinoa
#11
JOURNAL ARTICLE
Maria Alicia Rueda Huélamo, Alba Martínez Perlado, Valeria Consoli, Aurora García-Tejedor, Claudia Monika Haros, José Moisés Laparra Llopis
Food ingredients have critical effects on the maturation and development of the immune system, which innate - lymphoid (ILCs) and myeloid - cells play key roles as important regulators of energy storage and hepatic fat accumulation. Therefore, the objective of this study is to define potential links between a dietary immunonutritional induction of the selective functional differentiation of monocytes-derived macrophages, ILCs and lipid homeostasis in hepatocarcinoma (HCC)-developing mice. Hepatic chemically injured (diethylnitrosamine/thiacetamide) Rag2-/- and Rag2-/- Il2-/- mice were administered with serine-type protease inhibitors (SETIs) obtained from Chenopodium quinoa ...
March 12, 2024: Food & Function
https://read.qxmd.com/read/38467976/control-of-the-development-distribution-and-function-of-innate-like-lymphocytes-and-innate-lymphoid-cells-by%C3%A2-the-tissue-microenvironment
#12
REVIEW
Koichi Ikuta, Takuma Asahi, Guangwei Cui, Shinya Abe, Daichi Takami
Recently, considerable attention has been directed toward innate-like T cells (ITCs) and innate lymphoid cells (ILCs) owing to their indispensable contributions to immune responses, tissue homeostasis, and inflammation. Innate-like T cells include NKT cells, MAIT cells, and γδ T cells, whereas ILCs include NK cells, type 1 ILCs (ILC1s), type 2 ILCs (ILC2s), and type 3 ILCs (ILC3s). Many of these ITCs and ILCs are distributed to specific tissues and remain tissue-resident, while others, such as NK cells and some γδ T cells, circulate through the bloodstream...
2024: Advances in Experimental Medicine and Biology
https://read.qxmd.com/read/38457461/repeated-sensitization-of-mice-with-microfilariae-of-litomosoides-sigmodontis-induces-pulmonary-eosinophilia-in-an-il-33-dependent-manner
#13
JOURNAL ARTICLE
Benjamin Lenz, Alexandra Ehrens, Jesuthas Ajendra, Frederic Risch, Joséphine Gal, Anna-Lena Neumann, Julia J Reichwald, Wiebke Strutz, Henry J McSorley, Coralie Martin, Achim Hoerauf, Marc P Hübner
BACKGROUND: Eosinophilia is a hallmark of helminth infections and eosinophils are essential in the protective immune responses against helminths. Nevertheless, the distinct role of eosinophils during parasitic filarial infection, allergy and autoimmune disease-driven pathology is still not sufficiently understood. In this study, we established a mouse model for microfilariae-induced eosinophilic lung disease (ELD), a manifestation caused by eosinophil hyper-responsiveness within the lung...
March 8, 2024: PLoS Pathogens
https://read.qxmd.com/read/38430805/uhplc-ms-based-metabolomics-of-asthmatic-mice-reveals-metabolic-changes-in-group-2-innate-lymphoid-cells
#14
JOURNAL ARTICLE
Min Tang, Xianzong Da, Zhiwei Xu, Xiaoman Zhao, Haoquan Zhou
Helper Th2-type immune responses are essential in allergic airway diseases, including asthma and allergic rhinitis. Recent studies have indicated that group 2 innate lymphoid cells (ILC2s) play a crucial role in the occurrence and development of asthma. However, the metabolic profile of ILC2s and their regulatory mechanisms in asthma remain unclear. Therefore, we established two asthma mouse models: an ovalbumin (OVA)-induced asthma model and an IL-33-induced asthma model. We then used ultra-high-performance liquid chromatography/mass spectrometry (UHPLC/MS) to conduct high-throughput untargeted metabolic analysis of ILC2s in the lung tissues of the asthma models...
March 1, 2024: International Immunopharmacology
https://read.qxmd.com/read/38430129/interleukin-2-induced-skin-inflammation
#15
JOURNAL ARTICLE
Charline Sommer, Jarish N Cohen, Susann Dehmel, Vanessa Neuhaus, Dirk Schaudien, Armin Braun, Katherina Sewald, Michael D Rosenblum
Recombinant human IL-2 has been used to treat inflammatory diseases and cancer; however, side effects like skin rashes limit the use of this therapeutic. To identify key molecules and cells inducing this side effect, we characterized IL-2-induced cutaneous immune reactions and investigated the relevance of CD25 (IL-2 receptor α) in the process. We injected IL-2 intradermally into WT mice and observed increases in immune cell subsets in the skin with preferential increases in frequencies of IL-4- and IL-13-producing group 2 innate lymphoid cells and IL-17-producing dermal γδ T cells...
March 2, 2024: European Journal of Immunology
https://read.qxmd.com/read/38424193/il-27-induced-pd-l1-high-sca-1-innate-lymphoid-cells-suppress-contact-hypersensitivity-in-an-il-10-dependent-manner
#16
JOURNAL ARTICLE
Keun Young Min, Do-Kyun Kim, Min Geun Jo, Min Yeong Choi, Dajeong Lee, Jeong Won Park, Young-Jun Park, Yeonseok Chung, Young Mi Kim, Yeong-Min Park, Hyuk Soon Kim, Wahn Soo Choi
Innate lymphoid cells (ILCs) play an important role in maintaining tissue homeostasis and various inflammatory responses. ILCs are typically classified into three subsets, as is the case for T-cells. Recent studies have reported that IL-10-producing type 2 ILCs (ILC210 s) have an immunoregulatory function dependent on IL-10. However, the surface markers of ILC210 s and the role of ILC210 s in contact hypersensitivity (CHS) are largely unknown. Our study revealed that splenic ILC210 s are extensively included in PD-L1high Sca-1+ ILCs and that IL-27 amplifies the development of PD-L1high Sca-1+ ILCs and ILC210 s...
March 1, 2024: Experimental & Molecular Medicine
https://read.qxmd.com/read/38407132/lung-type-3-innate-lymphoid-cells-respond-early-following-mycobacterium-tuberculosis-infection
#17
JOURNAL ARTICLE
Shibali Das, Kuldeep Singh Chauhan, Mushtaq Ahmed, Sadia Akter, Lan Lu, Marco Colonna, Shabaana A Khader
Tuberculosis is the leading cause of death due to an infectious disease worldwide. Innate lymphoid type 3 cells (ILC3s) mediate early protection during Mycobacterium tuberculosis ( Mtb ) infection. However, the early signaling mechanisms that govern ILC3 activation or recruitment within the lung during Mtb infection are unclear. scRNA-seq analysis of Mtb -infected mouse lung innate lymphoid cells (ILCs) has revealed the presence of different clusters of ILC populations, suggesting heterogeneity. Using mouse models, we show that during Mtb infection, interleukin-1 receptor (IL-1R) signaling on epithelial cells drives ILC3 expansion and regulates ILC3 accumulation in the lung...
February 26, 2024: MBio
https://read.qxmd.com/read/38396288/cd200-fibroblasts-form-a-pro-resolving-mesenchymal-network-in-arthritis
#18
JOURNAL ARTICLE
Simon Rauber, Hashem Mohammadian, Christian Schmidkonz, Armin Atzinger, Alina Soare, Christoph Treutlein, Samuel Kemble, Christopher B Mahony, Manuel Geisthoff, Mario R Angeli, Maria G Raimondo, Cong Xu, Kai-Ting Yang, Le Lu, Hannah Labinsky, Mina S A Saad, Charles A Gwellem, Jiyang Chang, Kaiyue Huang, Eleni Kampylafka, Johannes Knitza, Rostyslav Bilyy, Jörg H W Distler, Megan M Hanlon, Ursula Fearon, Douglas J Veale, Frank W Roemer, Tobias Bäuerle, Hans M Maric, Simone Maschauer, Arif B Ekici, Christopher D Buckley, Adam P Croft, Torsten Kuwert, Olaf Prante, Juan D Cañete, Georg Schett, Andreas Ramming
Fibroblasts are important regulators of inflammation, but whether fibroblasts change phenotype during resolution of inflammation is not clear. Here we use positron emission tomography to detect fibroblast activation protein (FAP) as a means to visualize fibroblast activation in vivo during inflammation in humans. While tracer accumulation is high in active arthritis, it decreases after tumor necrosis factor and interleukin-17A inhibition. Biopsy-based single-cell RNA-sequencing analyses in experimental arthritis show that FAP signal reduction reflects a phenotypic switch from pro-inflammatory MMP3+ /IL6+ fibroblasts (high FAP internalization) to pro-resolving CD200+ DKK3+ fibroblasts (low FAP internalization)...
February 23, 2024: Nature Immunology
https://read.qxmd.com/read/38386557/the-cd27-cd70-pathway-negatively-regulates-visceral-adipose-tissue-resident-th2-cells-and-controls-metabolic-homeostasis
#19
JOURNAL ARTICLE
Kevin Englebert, Anaelle Taquin, Abdulkader Azouz, Valérie Acolty, Sylvie Vande Velde, Marie Vanhollebeke, Hadrien Innes, Louis Boon, Tibor Keler, Oberdan Leo, Stanislas Goriely, Muriel Moser, Guillaume Oldenhove
Adipose tissue homeostasis relies on the interplay between several regulatory lineages, such as type 2 innate lymphoid cells (ILC2s), T helper 2 (Th2) cells, regulatory T cells, eosinophils, and type 2 macrophages. Among them, ILC2s are numerically the dominant source of type 2 cytokines and are considered as major regulators of adiposity. Despite the overlap in immune effector molecules and sensitivity to alarmins (thymic stromal lymphopoietin and interleukin-33) between ILC2s and resident memory Th2 lymphocytes, the role of the adaptive axis of type 2 immunity remains unclear...
February 20, 2024: Cell Reports
https://read.qxmd.com/read/38381001/il-33-induces-cellular-and-exosomal-mir-146a-expression-as-a-feedback-inhibitor-of-mast-cell-function
#20
JOURNAL ARTICLE
Marcela T Taruselli, Amina Abdul Qayum, Daniel Abebayehu, Heather L Caslin, Jordan M Dailey, Aditya Kotha, Jason R Burchett, Sydney A Kee, Tania D Maldonado, Boyang Ren, Wei Chao, Lin Zou, Tamara T Haque, David Straus, John J Ryan
IL-33 is an inflammatory cytokine that promotes allergic disease by activating group 2 innate lymphoid cells, Th2 cells, and mast cells. IL-33 is increased in asthmatics, and its blockade suppresses asthma-like inflammation in mouse models. Homeostatic control of IL-33 signaling is poorly understood. Because the IL-33 receptor, ST2, acts via cascades used by the TLR family, similar feedback mechanisms may exist. MicroRNA (miR)-146a is induced by LPS-mediated TLR4 signaling and serves as a feedback inhibitor...
February 21, 2024: Journal of Immunology
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