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https://www.readbyqxmd.com/read/28353374/prediction-of-poor-short-term-prognosis-and-unmet-needs-in-advanced-chronic-obstructive-pulmonary-disease-use-of-the-two-minute-walking-distance-extracted-from-a-six-minute-walk-test
#1
Han-Yee Neo, Hui-Ying Xu, Huei-Yaw Wu, Allyn Hum
OBJECTIVES: Prognostic challenges hinder the identification of patients with advanced chronic obstructive pulmonary disease (COPD) for timely palliative interventions. We postulate that a two-minute derivative (two-minute walking distance [2MWD]) of a standard six-minute walk test (6MWT) can identify frail subjects with poorer survival for early palliative intervention. The primary outcome of interest is mortality at 18 months. Secondary objectives include evaluation of the relationship between the 2MWD and ability to self-care, dyspnea-related disabilities, nutrition, forced expiratory volume in first second (FEV1), quality of life (QoL), and comorbidity burden...
March 29, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28340165/attitudes-toward-opioids-and-risk-of-misuse-abuse-in-patients-with-chronic-noncancer-pain-receiving-long-term-opioid-therapy
#2
Grisell Vargas-Schaffer, Jennifer Cogan
Objectives.:  To determine the attitudes of patients toward long-term opioid therapy (LtOT) and the potential risk of misuse/abuse in patients with chronic noncancer pain (CNCP). Design.:  Prospective, descriptive epidemiological study. Setting.:  Multidisciplinary tertiary care pain center within the Montreal University Health Center. Subjects.:  Patients who had had at least one visit at least one year prior to the invitation...
March 7, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28192376/reasons-for-discontinuation-of-long-term-opioid-therapy-in-patients-with-and-without-substance-use-disorders
#3
Travis I Lovejoy, Benjamin J Morasco, Michael I Demidenko, Thomas H A Meath, Joseph W Frank, Steven K Dobscha
Several factors may accelerate opioid discontinuation rates, including lack of information about the long-term effectiveness of opioids for chronic pain, heightened awareness about opioid-related adverse events, closer monitoring of patients for opioid-related aberrant behaviors, and greater restrictions around opioid prescribing. Rates of discontinuation may be most pronounced in patients deemed to be at "high risk." The purpose of this study was to compare reasons for discontinuation of long-term opioid therapy (LTOT) between patients with and without substance use disorder (SUD) diagnoses receiving care within a major U...
March 2017: Pain
https://www.readbyqxmd.com/read/28142139/long-term-oxygen-therapy-comparison-of-the-german-and-british-guidelines
#4
Friederike Sophie Magnet, Sarah Bettina Schwarz, Jens Callegari, Carl-Peter Criée, Jan Hendrik Storre, Wolfram Windisch
BACKGROUND: The German guideline on long-term oxygen therapy (LTOT) was published in 2008 by the German Respiratory Society (DGP), while the British Thoracic Society (BTS) published their most recent guideline in 2015. OBJECTIVES: The aim of the present article was to highlight the major areas of consensus and disagreement in the recently published BTS and DGP guidelines on LTOT. METHODS: The BTS and DGP guidelines were directly compared in terms of congruencies and differences...
2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28123292/burn-injury-during-long-term-oxygen-therapy-in-denmark-and-sweden-the-potential-role-of-smoking
#5
Hanan A Tanash, Thomas Ringbaek, Fredrik Huss, Magnus Ekström
BACKGROUND: Long-term oxygen therapy (LTOT) increases life expectancy in patients with COPD and severe hypoxemia. Smoking is the main cause of burn injury during LTOT. Policy regarding smoking while on LTOT varies between countries. In this study, we compare the incidence of burn injury that required contact with a health care specialist, between Sweden (a country with a strict policy regarding smoking while on LTOT) and Denmark (a country with less strict smoking policy). METHODS: This was a population-based, cohort study of patients initiating LTOT due to any cause in Sweden and Denmark...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28116924/oxygen-therapy-devices-and-portable-ventilators-for-improved-physical-activity-in-daily-life-in-patients-with-chronic-respiratory-disease
#6
REVIEW
Karina Couto Furlanetto, Fabio Pitta
Patients with hypoxemia and chronic respiratory failure may need to use oxygen therapy to correct hypoxemia and to use ventilatory support to augment alveolar ventilation, reverse abnormalities in blood gases (in particular hypercapnia) and reduce the work of breathing. Areas covered: This narrative review provides an overview on the use of oxygen therapy devices or portable ventilators for improved physical activity in daily life (PADL) as well as discusses the issue of lower mobility in daily life among stable patients with chronic respiratory disease who present indication for long-term oxygen therapy (LTOT) or home-based noninvasive ventilation (NIV)...
February 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28069009/multi-center-randomized-placebo-controlled-trial-of-nocturnal-oxygen-therapy-in-chronic-obstructive-pulmonary-disease-a-study-protocol-for-the-inox-trial
#7
Yves Lacasse, Sarah Bernard, Frédéric Sériès, Van Hung Nguyen, Jean Bourbeau, Shawn Aaron, François Maltais
BACKGROUND: Long-term oxygen therapy (LTOT) is the only component of the management of chronic obstructive pulmonary disease (COPD) that improves survival in patients with severe daytime hypoxemia. LTOT is usually provided by a stationary oxygen concentrator and is recommended to be used for at least 15-18 h a day. Several studies have demonstrated a deterioration in arterial blood gas pressures and oxygen saturation during sleep in patients with COPD, even in those not qualifying for LTOT...
January 9, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27993558/higher-prescription-opioid-dose-is-associated-with-worse-patient-reported-pain-outcomes-and-more-health-care-utilization
#8
Benjamin J Morasco, Bobbi Jo Yarborough, Ning X Smith, Steven K Dobscha, Richard A Deyo, Nancy A Perrin, Carla A Green
Some previous research has examined pain-related variables on the basis of prescription opioid dose, but data from studies involving patient-reported outcomes have been limited. This study examined the relationships between prescription opioid dose and self-reported pain intensity, function, quality of life, and mental health. Participants were recruited from 2 large integrated health systems, Kaiser Permanente Northwest (n = 331) and VA Portland Health Care System (n = 186). To be included, participants had to have musculoskeletal pain diagnoses and be receiving stable doses of long-term opioid therapy...
April 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27983876/risk-factors-of-poor-outcomes-after-admission-for-a-copd-exacerbation-multivariate-logistic-predictive-models
#9
Juan Luis García-Rivero, Cristina Esquinas, Miriam Barrecheguren, Marc Bonnin-Vilaplana, Patricia García-Sidro, Alberto Herrejón, Carlos Martinez-Rivera, Rosa Malo de Molina, Pedro Jorge Marcos, Sagrario Mayoralas, Elsa Naval, Jose Antonio Ros, Manuel Valle, Marc Miravitlles
The aim of this study was to identify a multivariate model to predict poor outcomes after admission for exacerbation of chronic obstructive pulmonary disease (COPD).  We performed a multicenter, observational, prospective study. Patients admitted to hospital for COPD were followed up for 3 months. Relevant clinical variables at admission were selected. For each variable, the best cut-offs for the risk of poor outcome were identified using receiver operating characteristic (ROC) curves. Finally, a stepwise logistic regression model was performed...
December 16, 2016: COPD
https://www.readbyqxmd.com/read/27886372/oxygen-for-breathlessness-in-patients-with-chronic-obstructive-pulmonary-disease-who-do-not-qualify-for-home-oxygen-therapy
#10
REVIEW
Magnus Ekström, Zainab Ahmadi, Anna Bornefalk-Hermansson, Amy Abernethy, David Currow
BACKGROUND: Breathlessness is a cardinal symptom of chronic obstructive pulmonary disease (COPD). Long-term oxygen therapy (LTOT) is given to improve survival time in people with COPD and severe chronic hypoxaemia at rest. The efficacy of oxygen therapy for breathlessness and health-related quality of life (HRQOL) in people with COPD and mild or no hypoxaemia who do not meet the criteria for LTOT has not been established. OBJECTIVES: To determine the efficacy of oxygen versus air in mildly hypoxaemic or non-hypoxaemic patients with COPD in terms of (1) breathlessness; (2) HRQOL; (3) patient preference whether to continue therapy; and (4) oxygen-related adverse events...
November 25, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27799763/prescription-of-opioids-for-breathlessness-in-end-stage-copd-a-national-population-based-study
#11
Zainab Ahmadi, Eva Bernelid, David C Currow, Magnus Ekström
BACKGROUND: Low-dose opioids can relieve breathlessness but may be underused in late-stage COPD due to fear of complications, contributing to poor symptom control. OBJECTIVES: We aimed to study the period prevalence and indications of opioids actually prescribed in people with end-stage COPD. METHODS: The study was a longitudinal, population-based study of patients starting long-term oxygen therapy (LTOT) for COPD between October 1, 2005 and June 30, 2009 in Sweden...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27649490/long-term-oxygen-therapy-24-vs-15-h-day-and-mortality-in-chronic-obstructive-pulmonary-disease
#12
Zainab Ahmadi, Josefin Sundh, Anna Bornefalk-Hermansson, Magnus Ekström
Long-term oxygen therapy (LTOT) ≥ 15 h/day improves survival in hypoxemic chronic obstructive pulmonary disease (COPD). LTOT 24 h/day is often recommended but may pose an unnecessary burden with no clear survival benefit compared with LTOT 15 h/day. The aim was to test the hypothesis that LTOT 24 h/day decreases all-cause, respiratory, and cardiovascular mortality compared to LTOT 15 h/day in hypoxemic COPD. This was a prospective, observational, population-based study of COPD patients starting LTOT between October 1, 2005 and June 30, 2009 in Sweden...
2016: PloS One
https://www.readbyqxmd.com/read/27610580/the-effect-of-substance-use-disorders-on-the-association-between-guideline-concordant-long-term-opioid-therapy-and-all-cause-mortality
#13
Julie R Gaither, Joseph L Goulet, William C Becker, Stephen Crystal, E Jennifer Edelman, Kirsha Gordon, Robert D Kerns, David Rimland, Melissa Skanderson, Amy C Justice, David A Fiellin
OBJECTIVE: Patients with substance use disorders (SUDs) prescribed long-term opioid therapy (LtOT) are at risk for overdose and mortality. Prior research has shown that receipt of LtOT in accordance with clinical practice guidelines has the potential to mitigate these outcomes. Our objective was to determine whether the presence of a SUD modifies the association between guideline-concordant care and 1-year all-cause mortality among patients receiving LtOT for pain. METHODS: Among HIV+ and HIV- patients initiating LtOT (≥90 days opioids) between 2000 and 2010 as part of the Veterans Aging Cohort Study, we used time-updated Cox regression and propensity-score matching to examine-stratified by SUD status-the association between 1-year all-cause mortality and 3 quality indicators derived from national opioid-prescribing guidelines...
November 2016: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/27408629/self-fill-oxygen-technology-benefits-for-patients-healthcare-providers-and-the-environment
#14
REVIEW
Phyllis Murphie, Nick Hex, Jo Setters, Stuart Little
UNLABELLED: "Non-delivery" home oxygen technologies that allow self-filling of ambulatory oxygen cylinders are emerging. They can offer a relatively unlimited supply of ambulatory oxygen in suitably assessed people who require long-term oxygen therapy (LTOT), providing they can use these systems safely and effectively. This allows users to be self-sufficient and facilitates longer periods of time away from home. The evolution and evidence base of this technology is reported with the experience of a national service review in Scotland (UK)...
June 2016: Breathe
https://www.readbyqxmd.com/read/27220917/major-depression-in-long-term-oxygen-therapy-dependent-chronic-obstructive-pulmonary-disease
#15
Fatih Kayhan, Faik Ilik, Harun Karamanli, Ahmet Cemal Pazarli, Ayşegül Kayhan
PURPOSE: We aimed to investigate the frequency of major depression (MD) in long-term oxygen therapy (LTOT) dependent chronic obstructive pulmonary disease (COPD) patients and the effect of depression on patients' compliance with the treatment. DESIGN AND METHODS: Fifty-four consecutive patients were enrolled in the study and diagnosed as stage 4 COPD according to Global Initiative for Chronic Obstructive Lung Disease guideline. MD was diagnosed with the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition/Clinical Version...
May 25, 2016: Perspectives in Psychiatric Care
https://www.readbyqxmd.com/read/27154486/management-of-problematic-behaviours-among-individuals-on-long-term-opioid-therapy-protocol-for-a-delphi-study
#16
Jessica S Merlin, Sarah R Young, Soraya Azari, William C Becker, Jane M Liebschutz, Jamie Pomeranz, Payel Roy, Shalini Saini, Joanna L Starrels, E Jennifer Edelman
INTRODUCTION: Given the sharp rise in opioid prescribing and heightened recognition of opioid addiction and overdose, opioid safety has become a priority. Clinical guidelines on long-term opioid therapy (LTOT) for chronic pain consistently recommend routine monitoring and screening for problematic behaviours. Yet, there is no consensus definition regarding what constitutes a problematic behaviour, and recommendations for appropriate management to inform front-line providers, researchers and policymakers are lacking...
2016: BMJ Open
https://www.readbyqxmd.com/read/27118875/the-severe-respiratory-insufficiency-questionnaire-for-subjects-with-copd-with-long-term-oxygen-therapy
#17
Stephan Walterspacher, Johanna July, Martin Kohlhäufl, Peter Rzehak, Wolfram Windisch
BACKGROUND: Respiratory insufficiency in COPD may present as hypoxic and/or hypercapnic respiratory failure treated with long-term oxygen therapy (LTOT) and/or noninvasive ventilation (NIV) with LTOT. The Severe Respiratory Insufficiency Questionnaire (SRI) is a tool for the assessment of health-related quality of life (HRQOL) in subjects receiving NIV. However, it remains unclear whether the SRI is also capable of assessing and discriminating HRQOL in subjects receiving LTOT. METHODS: Stable subjects with COPD receiving LTOT or NIV + LTOT (NIV) were prospectively recruited and completed the SRI, lung function tests, and blood gases...
September 2016: Respiratory Care
https://www.readbyqxmd.com/read/27018995/is-there-any-additional-effect-of-tele-assistance-on-long-term-care-programmes-in-hypercapnic-copd-patients-a-retrospective-study
#18
Michele Vitacca, Mara Paneroni, Francesco Grossetti, Nicolino Ambrosino
UNLABELLED: The evidence for tele-assistance (TA) in hypercapnic chronic obstructive pulmonary disease (COPD) patients on long-term oxygen therapy (LTOT) is scarce. The aim of this study was to evaluate the effects of addition of long-term TA to LTOT with or without non-invasive ventilation (NIV) in these patients. Retrospective analysis of a previous randomised study of patients on LTOT. According to the care programme patients were divided into Group 1: LTOT; Group 2: LTOT + NIV; Group 3: LTOT + TA and Group 4: LTOT + NIV+TA...
October 2016: COPD
https://www.readbyqxmd.com/read/27009834/cardiovascular-and-antacid-treatment-and-mortality-in-oxygen-dependent-pulmonary-fibrosis-a-population-based-longitudinal-study
#19
Magnus Ekström, Anna Bornefalk-Hermansson
BACKGROUND AND OBJECTIVE: Severe idiopathic pulmonary fibrosis is associated with an increased risk of cardiovascular disease and gastro-oesophageal reflux, which may influence prognosis. We evaluated associations between cardiovascular and antacid medications, and mortality, in oxygen-dependent pulmonary fibrosis (PF) of unknown cause. METHODS: Prospective population-based study of adults starting long-term oxygen therapy (LTOT) for PF in Sweden 2005-2009. PF of unknown cause was defined by excluding patients with known or probable secondary PF...
May 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/26988312/the-opioid-epidemic-and-the-long-term-opioid-therapy-for-chronic-noncancer-pain-revisited-a-transatlantic-perspective
#20
Winfried Häuser, Frank Petzke, Lukas Radbruch, Thomas R Tölle
The rise of opioid prescriptions and associated deaths ('opioid epidemic') in North America has evoked worldwide discussions on the long-term efficacy and safety of long-term opioid therapy (LtOT) for chronic noncancer pain (CNCP). We discuss if the opioid epidemic is a real worldwide or a more North American phenomenon. We consider reasons of the opioid epidemic. We highlight differences in the appraisal of the evidence of recent systematic reviews on LtOT for CNCP of US and European authors. We discuss similarities and differences of recent North American and European guidelines on LtOT for chronic CNCP...
2016: Pain Management
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