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https://www.readbyqxmd.com/read/28636510/the-balance-of-omega-3-polyunsaturated-fatty-acids-for-reducing-residual-risks-in-patients-with-coronary-artery-disease
#1
Yuji Nishizaki, Kazunori Shimada, Hiroyuki Daida
Residual risk, which cannot be prevented by statins alone, must be controlled for inhibiting the onset of coronary events. Omega-3 polyunsaturated fatty acids (PUFAs) play an important role in controlling residual risk. The Japan eicosapentaenoic acid (EPA) Lipid Intervention Study demonstrated the inhibitory effect of high-purity EPA preparations on the residual risk of cardiovascular events. Omega-3 PUFAs inhibit coronary artery disease (CAD) through various actions, including triglyceride-lowering action...
March 21, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28634822/the-ratio-of-eicosapentaenoic-acid-epa-to-arachidonic-acid-may-be-a-residual-risk-marker-in-stable-coronary-artery-disease-patients-receiving-treatment-with-statin-following-epa-therapy
#2
Shigemasa Tani, Ken Nagao, Kenji Kawauchi, Tsukasa Yagi, Wataru Atsumi, Rei Matsuo, Atsushi Hirayama
BACKGROUND: We investigated the relationship between the eicosapentaenoic acid (EPA)/arachidonic acid (AA) ratio and non-high-density lipoprotein cholesterol (non-HDL-C) level, a major residual risk of coronary artery disease (CAD), in statin-treated CAD patients following EPA therapy. METHODS: We conducted a 6-month, prospective, randomized clinical trial to investigate the effect of the additional administration of EPA on the EPA/AA ratio and the serum non-HDL-C level in stable CAD patients receiving statin treatment...
June 20, 2017: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/28633110/emerging-contaminants-related-to-the-occurrence-of-forest-fires-in-the-spanish-mediterranean
#3
Julian Campo, María Lorenzo, Erik L H Cammeraat, Yolanda Picó, Vicente Andreu
Forest fires can be a source of contamination because, among others, of the use of chemicals to their extinction (flame retardants, FRs), or by the production of Polycyclic Aromatic Hydrocarbons (PAHs) derived from high temperature alteration of organic matter. Up to our knowledge, this study is the first to assess the direct (PAHs 16 on the USA EPA's priority list), and indirect [tri- to hepta- brominated diphenyl ethers (PBDEs), organophosphorus flame retardants (PFRs) and perfluoroalkyl substances (PFASs)] contamination related to forest fires...
June 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28632272/interfacial-synthesis-of-a-three-dimensional-hierarchical-mos2-ns-ag-np-nanocomposite-as-a-sers-nanosensor-for-ultrasensitive-thiram-detection
#4
Xiu Liang, Yi-Shuo Wang, Ting-Ting You, Xiao-Juan Zhang, Nan Yang, Guang-Sheng Wang, Peng-Gang Yin
Interfacial self-assembly of ordered nanostructures at oil-water interfaces towards the fabrication of nanofilms has attracted the interest of plenty of scientists, since its discovery in 2004. Herein, further developments have been achieved, and we report a new strategy for the synthesis of a three-dimensional (3D) hierarchical nanostructure, through an interfacial synthesis driven microemulsion process. Thus, the synthesis route has been simplified, with the rigorous experimental conditions of traditional compositing technology...
June 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28631078/evaluation-of-the-association-between-sleep-apnea-and-polyunsaturated-fatty-acids-profiles-in-patients-after-percutaneous-coronary-intervention
#5
Keisuke Nakabayashi, Kentaro Jujo, Katsumi Saito, Toshiaki Oka, Nobuhisa Hagiwara
The long-term outcome is poor in patients with sleep apnea and cardiovascular disease. Polyunsaturated fatty acid (PUFA) is also known as an independent predictor for adverse clinical events. However, the profile of PUFA in sleep apnea patients with coronary artery disease (CAD) is still unclear. This study aimed to clarify the association between sleep apnea and PUFA profiles in patients with CAD. Two hundred seventy-four consecutive patients undergoing percutaneous coronary intervention (PCI) were screened for sleep apnea using nocturnal oximetry...
June 19, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28629180/bioavailability-of-dietary-omega-3-fatty-acids-added-to-a-variety-of-sausages-in-healthy-individuals
#6
Anton Köhler, Johanna Heinrich, Clemens von Schacky
A low Omega-3 Index (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in erythrocytes) is associated with cardiac, cerebral, and other health issues. Intake of EPA and DHA, but not of alpha-linolenic acid (ALA), increases the Omega-3 Index. We investigated bioavailability, safety, palatability and tolerability of EPA and DHA in a novel source: a variety of sausages. We screened 96 healthy volunteers, and recruited 44 with an Omega-3 Index <5%. Participants were randomly assigned to receive a variety of sausages enriched with approximately 250 mg EPA and DHA per 80 g (n = 22) daily for 8 weeks, or matching placebo sausages (n = 22)...
June 19, 2017: Nutrients
https://www.readbyqxmd.com/read/28628865/urban-emissions-hotspots-quantifying-vehicle-congestion-and-air-pollution-using-mobile-phone-gps-data
#7
Conor K Gately, Lucy R Hutyra, Scott Peterson, Ian Sue Wing
On-road emissions vary widely on time scales as short as minutes and length scales as short as tens of meters. Detailed data on emissions at these scales are a prerequisite to accurately quantifying ambient pollution concentrations and identifying hotspots of human exposure within urban areas. We construct a highly resolved inventory of hourly fluxes of CO, NO2, NOx, PM2.5 and CO2 from road vehicles on 280,000 road segments in eastern Massachusetts for the year 2012. Our inventory integrates a large database of hourly vehicle speeds derived from mobile phone and vehicle GPS data with multiple regional datasets of vehicle flows, fleet characteristics, and local meteorology...
June 16, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28628305/variation-in-methane-emission-rates-from-well-pads-in-four-oil-and-gas-basins-with-contrasting-production-volumes-and-compositions
#8
Anna M Robertson, Rachel Edie, Dustin Snare, Jeffrey Soltis, Robert Alexander Field, Matthew D Burkhart, Clay S Bell, Daniel Zimmerle, Shane M Murphy
Atmospheric methane emissions from active natural gas production sites in normal operation were quantified using an inverse Gaussian method (EPA's OTM 33a) in four major U.S. basins/plays: Upper Green River (UGR, Wyoming), Denver-Julesburg (DJ, Colorado), Uintah (Utah), and Fayetteville (FV, Arkansas). In DJ, Uintah, and FV, 72 - 83% of total measured emissions were from 20% of the well pads, while in UGR the highest 20% of emitting well pads only contributed 54% of total emissions. The total mass of methane emitted as a percent of gross methane produced, termed throughput-normalized methane average (TNMA) and determined by bootstrapping measurements from each basin, varied widely between basins and was (95% CI): 0...
June 19, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28627710/oil-and-eicosapentaenoic-acid-production-by-the-diatom-phaeodactylum-tricornutum-cultivated-outdoors-in-green-wall-panel-gwp%C3%A2-reactors
#9
Liliana Rodolfi, Natascia Biondi, Alessia Guccione, Niccolò Bassi, Massimo D'Ottavio, Gimena Arganaraz, Mario R Tredici
Phaeodactylum tricornutum is a widely studied diatom and has been proposed as a source of oil and polyunsaturated fatty acids (PUFA), particularly eicosapentaenoic acid (EPA). Recent studies indicate that lipid accumulation occurs under nutritional stress. Aim of this research was to determine how changes in nitrogen availability affect productivity, oil yield and fatty acid (FA) composition of P. tricornutum UTEX 640. After preliminary laboratory trials, outdoor experiments were carried out in 40-L GWP® reactors under different nitrogen regimes in batch...
June 19, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28626140/long-chain-polyunsaturated-fatty-acid-supplementation-improves-mood-in-elderly-japanese-men
#10
Hisanori Tokuda, Toshiaki Sueyasu, Hiroshi Kawashima, Hiroshi Shibata, Yoshihiko Koga
Although several studies have reported the effects of long-chain polyunsaturated fatty acid (LCPUFA) supplementation on the mood in healthy adults, the effects of LCPUFA on elderly individuals remain unclear. Thus, we hypothesized that LCPUFA supplementation improves mood in the elderly. To address this hypothesis, 115 elderly Japanese men aged 55-64 years were assigned and randomly allocated to the LCPUFA or placebo group. Participants received 4 weeks of supplementation with LCPUFAcontaining oil (docosahexaenoic acid (DHA) 300 mg/day, eicosapentaenoic acid (EPA) 100 mg/day, arachidonic acid (ARA) 120 mg/day) or a placebo oil...
June 13, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28625818/quantitative-assessment-of-lung-and-bladder-cancer-risk-and-oral-exposure-to-inorganic-arsenic-meta-regression-analyses-of-epidemiological-data
#11
Heather N Lynch, Ke Zu, Erin M Kennedy, Thuy Lam, Xiaobin Liu, Daniella M Pizzurro, Christine T Loftus, Lorenz R Rhomberg
Inorganic arsenic (iAs) in drinking water varies geographically and is prevalent worldwide. While exposures in the US are generally low, there are some areas with higher levels of naturally occurring iAs (potentially >100μg/L) where residents rely on unregulated drinking water wells. Much of the evidence on the association between iAs and cancer comes from epidemiological studies conducted in South American and Asian populations. These populations have generally been exposed to much higher levels of iAs and have differing underlying characteristics, both of which make comparing them to Western populations difficult...
June 16, 2017: Environment International
https://www.readbyqxmd.com/read/28625107/associations-between-omega-3-fatty-acids-and-25-oh-d-and-psychological-distress-among-inuit-in-canada
#12
Hans-Ragnar Skogli, Dominique Geoffroy, Hope A Weiler, Grethe S Tell, Laurence J Kirmayer, Grace M Egeland
BACKGROUND: Inuit in Canada have experienced dietary changes over recent generations, but how this relates to psychological distress has not been investigated. OBJECTIVE: To evaluate how nutritional biomarkers are related to psychological distress. DESIGN: A total of 36 communities in northern Canada participated in the International Polar Year Inuit Health Survey (2007-2008). Of 2796 households, 1901 (68%) participated; 1699 Inuit adults gave blood samples for biomarker analysis and answered the Kessler 6-item psychological distress questionnaire (K6)...
2017: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/28624245/a-biorefinery-for-nannochloropsis-induction-harvesting-and-extraction-of-epa-rich-oil-and-high-value-protein
#13
REVIEW
Elvis T Chua, Peer M Schenk
Microalgae have been studied as biofactories for almost four decades. Yet, even until today, many aspects of microalgae farming and processing are still considered exploratory because of the uniqueness of each microalgal species. Thus, it is important to develop the entire process of microalgae farming: from culturing to harvesting, and down to extracting the desired high-value products. Based on its rapid growth and high oil productivities, Nannochloropsis sp. is of particular interest to many industries for the production of high-value oil containing omega-3 fatty acids, specifically eicosapentaenoic acid (EPA), but also several other products...
May 21, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28617271/modelling-and-optimization-of-land-use-land-cover-change-in-a-developing-urban-catchment
#14
Ping Xu, Fei Gao, Junchao He, Xinxin Ren, Weijin Xi
The impacts of land use/cover change (LUCC) on hydrological processes and water resources are mainly reflected in changes in runoff and pollutant variations. Low impact development (LID) technology is utilized as an effective strategy to control urban stormwater runoff and pollution in the urban catchment. In this study, the impact of LUCC on runoff and pollutants in an urbanizing catchment of Guang-Ming New District in Shenzhen, China, were quantified using a dynamic rainfall-runoff model with the EPA Storm Water Management Model (SWMM)...
June 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28616453/reproducibility-discrepancies-following-reanalysis-of-raw-data-for-a-previously-published-study-on-diisononyl-phthalate-dinp-in-rats
#15
Min Chen, Rebecca Alyea, Peter Morfeld, Rainer Otter, Jessica Kemmerling, Christine Palermo
A 2011 publication by Boberg et al. entitled "Reproductive and behavioral effects of diisononyl phthalate (DINP) in perinatally exposed rats" [1] reported statistically significant changes in sperm parameters, testicular histopathology, anogenital distance and retained nipples in developing males. Using the statistical methods as reported by Boberg et al. (2011) [1], we reanalyzed the publically available raw data ([dataset] US EPA (United States Environmental Protection Agency), 2016) [2]. The output of our reanalysis and the discordances with the data as published in Boberg et al...
August 2017: Data in Brief
https://www.readbyqxmd.com/read/28614393/hypoxia-inducible-factor-hif-transcription-factor-family-expansion-diversification-divergence-and-selection-in-eukaryotes
#16
Allie M Graham, Jason S Presnell
Hypoxia inducible factor (HIF) transcription factors are crucial for regulating a variety of cellular activities in response to oxygen stress (hypoxia). In this study, we determine the evolutionary history of HIF genes and their associated transactivation domains, as well as perform selection and functional divergence analyses across their four characteristic domains. Here we show that the HIF genes are restricted to metazoans: At least one HIF-α homolog is found within the genomes of non-bilaterians and bilaterian invertebrates, while most vertebrate genomes contain between two and six HIF-α genes...
2017: PloS One
https://www.readbyqxmd.com/read/28614060/dietary-n-3-polyunsaturated-fatty-acids-fish-consumption-and-endometrial-cancer-risk-a-meta-analysis-of-epidemiological-studies
#17
Rui Hou, Shen-Shen Yao, Jia Liu, Lian-Lian Wang, Lang Wu, Luo Jiang
The relationship between intake of fish and n-3 fatty acids and endometrial cancer risk has not been consistent across epidemiological studies. We quantitatively assessed the aforementioned association through a systematic review and meta-analysis. PubMed and Embase were searched through March 2017 for eligible epidemiological studies. Fixed or random-effects models were used to pool relative risks (RRs) and 95% confidence intervals (CIs). The dose-response relationship was also evaluated. Based on the literature search, five prospective studies and 11 case-control studies were identified...
May 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28611355/improved-efficacy-of-an-arthropod-toxin-expressing-fungus-against-insecticide-resistant-malaria-vector-mosquitoes
#18
Etienne Bilgo, Brian Lovett, Weiguo Fang, Niraj Bende, Glenn F King, Abdoulaye Diabate, Raymond J St Leger
The continued success of malaria control efforts requires the development, study and implementation of new technologies that circumvent insecticide resistance. We previously demonstrated that fungal pathogens can provide an effective delivery system for mosquitocidal or malariacidal biomolecules. Here we compared genes from arthropod predators encoding insect specific sodium, potassium and calcium channel blockers for their ability to improve the efficacy of Metarhizium against wild-caught, insecticide-resistant anophelines...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28606239/-effect-of-eicosapentaenoic-acid-on-mrna-expression-of-tight-junction-protein-zo-1-in-intestinal-epithelial-cells-after-escherichia-coli-lf82-infection
#19
Li-Jun Hao, Yan Lin, Wei Zhang, Jiao Tian, Ya Wang, Peng-De Chen, Chong-Kang Hu, Ling-Chao Zeng, Jie Yang, Bao-Xi Wang, Xun Jiang
OBJECTIVE: To investigate the change in the expression of tight junction protein ZO-1 in intestinal epithelial cells (Caco-2 cells) and the protective effect of eicosapentaenoic acid (EPA) after adherent-invasive Escherichia coli (E.coli) LF82 infection. METHODS: The Caco-2 cell line was used to establish an in vitro model of tight junction of intestinal epithelial cells. Caco-2 cells were divided into EPA treatment groups (0, 25, 50, 100, and 200 μmol/L EPA) and EPA (0, 25, 50, 100, and 200 μmol/L EPA)+E...
June 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28606216/comparable-reductions-in-hyperpnoea-induced-bronchoconstriction-and-markers-of-airway-inflammation-after-supplementation-with-6%C3%A2-2-and-3%C3%A2-1-g-d-of-long-chain-n-3-pufa-in-adults-with-asthma
#20
Neil C Williams, Kirsty A Hunter, Dominick E Shaw, Kim G Jackson, Graham R Sharpe, Michael A Johnson
Although high dose n-3 PUFA supplementation reduces exercise- and hyperpnoea-induced bronchoconstriction (EIB/HIB), there are concurrent issues with cost, compliance and gastrointestinal discomfort. It is thus pertinent to establish the efficacy of lower n-3 PUFA doses. Eight male adults with asthma and HIB and eight controls without asthma were randomly supplemented with two n-3 PUFA doses (6·2 g/d (3·7 g EPA and 2·5 g DHA) and 3·1 g/d (1·8 g EPA and 1·3 g DHA)) and a placebo, each for 21 d followed by 14 d washout...
June 13, 2017: British Journal of Nutrition
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