keyword
https://read.qxmd.com/read/38493279/accumulation-of-docosapentaenoic-acid-n-3-dpa-in-a-novel-isolate-of-the-marine-ichthyosporean-sphaeroforma-arctica
#1
JOURNAL ARTICLE
Qiang Wilson Yan, Ying-Chun Liu, Christa Barrett, Kelly Haake, Daniel Seeler, Oliver May, Ross Zirkle
OBJECTIVE: Currently, there is lack of a consistent and highly enriched source for docosapentaenoic acid (n-3 DPA, C22:5), and this work report the isolation of microorganism that naturally produces n-3 DPA. RESULTS: In this work, we screened microorganisms in our culture collections with the goal to isolate a strain with high levels of n-3 DPA. We isolated a strain of Sphaeroforma arctica that produces up to 11% n-3 DPA in total fatty acid and has a high n-3 DPA to DHA/EPA ratio...
March 16, 2024: Biotechnology Letters
https://read.qxmd.com/read/38491437/clinical-supervisors-experience-of-a-first-time-application-of-entrustable-professional-activities-in-clinical-supervision-of-medical-students-findings-from-a-swedish-pilot-study
#2
JOURNAL ARTICLE
Paul Pålsson, Anna Cederborg, Monica Johansson, Helena Vallo Hult, Silvana Naredi, Katarina Jood
BACKGROUND: Recently, all medical universities in Sweden jointly developed a framework for Entrustable Professional Activities (EPAs) for work-based training and assessment. This framework is now being introduced nationally in the new 6-year undergraduate medical programme that directly lead to a licence to practise. When EPAs are introduced, it is of central importance to gain clinical supervisors' acceptance to apply the framework in their supervision of students. The aim of this study was therefore to investigate how clinical supervisors, not familiar with EPAs, experience clinical supervision using the framework for EPAs...
March 15, 2024: BMC Medical Education
https://read.qxmd.com/read/38491054/potential-of-pinus-eldarica-medw-tree-bark-for-biomonitoring-polycyclic-aromatic-hydrocarbons-in-ambient-air
#3
JOURNAL ARTICLE
Sohrab Hasheminejad, Hossein Moradi, Mohsen Soleimani
Urban trees' biomonitoring of pollutants such as polycyclic aromatic hydrocarbons (PAHs) yields pertinent and useful data for air pollution management. The aim of this study was to biomonitor PAHs in pine (Pinus eldarica Medw.) trees in the city of Isfahan and identify their sources. In total, 34 samples of outer bark of the trees were collected and their contents of 16 EPA PAHs were analyzed. With a median value of 136.3 ng/g, the total PAH contents in tree barks varied from 53.4 to 705.2 ng/g. The average values of the diagnostic ratios for Ant/(Ant + Phe), Flu/(Flu + Py), BaA/(BaA + Chr) and IP/(IP + BP) were 0...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38490405/optimization-of-benzene-exposure-risk-assessment-an-integrated-approach-utilizing-internal-and-external-concentrations-with-a-focus-on-biomarkers-s-pma-t-t-ma
#4
JOURNAL ARTICLE
Fanwei Xu, Boshen Wang, Juan Hu, Na Cai, Lei Han, Minyun Jiang, Yuan Zhao, Baoli Zhu
In the majority of occupational settings within China, the concentrations of benzene are observed to fall markedly below the demarcated detection thresholds. Employing traditional risk assessment models, the presence of exceptionally low airborne benzene exposure concentrations may infuse heightened degrees of uncertainty. Consequently, the necessity arises to investigate risk assessment methodologies more apt for the prevalent exposure environment among employees. In the present study, a pharmacokinetic model premised on urinary benzene metabolites (S-PMA and t, t-MA) was employed to ascertain a more precise daily airborne benzene exposure concentration per individual...
March 13, 2024: Science of the Total Environment
https://read.qxmd.com/read/38488912/health-risk-assessments-of-heavy-metals-and-trace-elements-exposure-in-the-breast-milk-of-lactating-mothers-in-the-northeastern-iran
#5
JOURNAL ARTICLE
Shiva Rahati, Mohammad Hashemi, Arezoo Orooji, Asma Afshari, Seyedeh Belin Tavakoly Sany
Mother's breast milk is a natural and complete food for infants but can be a main source of exposure to toxic pollutants. These pollutants can negatively affect the health of the infant. Therefore, conducting biomonitoring surveys is essential to evaluate such health effects in toxicological research. This study aimed to estimate the probable health risks for infants exposed to essential and non-essential trace elements through breast milk ingestion. This descriptive-analytical, cross-sectional study was performed on 90 breastfeeding mothers referred to the health centers in Mashhad, Iran in January 2021...
March 15, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38488423/a-modified-delphi-consensus-approach-to-define-entrustable-professional-activities-for-neurocritical-care-advanced-practice-providers
#6
JOURNAL ARTICLE
Daniel S Harrison, Erika J Sigman, Judy H Ch'ang, Aarti Sarwal, Abigale Celotto, Alexandra Malone, Ariel Nowicki, Ashley Martin, Bryan Boling, Christa O'Hana S Nobleza, Christopher Reeves, David M Greer, Diane McLaughlin, Elizabeth O'B Woods, Emmaculate Fields, Erica Perets, Gemi E Jannotta, Jennifer Mears, Kaitlyn Twomey, Kelly A Rath, Kelly Peronti, Krista M Garner, Matthew B Bevers, Nicholas A Morris, Paola Martinez, Sahar Zafar, Sarah Livesay, Sarah Wahlster, Thomas Lawson, Catherine S W Albin
OBJECTIVES: To define consensus entrustable professional activities (EPAs) for neurocritical care (NCC) advanced practice providers (APPs), establish validity evidence for the EPAs, and evaluate factors that inform entrustment expectations of NCC APP supervisors. DESIGN: A three-round modified Delphi consensus process followed by application of the EQual rubric and assessment of generalizability by clinicians not affiliated with academic medical centers. SETTING: Electronic surveys...
March 15, 2024: Critical Care Medicine
https://read.qxmd.com/read/38484997/from-soil-to-health-hazards-heavy-metals-contamination-in-northern-india-and-health-risk-assessment
#7
JOURNAL ARTICLE
Vidisha Upadhyay, Archana Kumari, Sunil Kumar
Heavy metals contamination in soil is a global concern affecting the environment with far-reaching consequences for ecosystems and the health of human beings. Heavy metals contamination of soil entails a significant threat to the environment and human health. This research paper focuses on the quantification of heavy metals contamination in soil in Kanpur district, a highly industrialized and densely populated region in India. The study was aimed to identify the sources of heavy metals, map their spatial distribution, and evaluate the potential implications on the environment and human well-being...
March 12, 2024: Chemosphere
https://read.qxmd.com/read/38483972/feasibility-of-replacing-fish-oil-with-sunflower-oil-on-the-growth-body-composition-fatty-acid-profile-antioxidant-activity-stress-response-and-blood-biomarkers-of-labeo-rohita
#8
JOURNAL ARTICLE
Muhammad Asghar, Noor Khan, Mahroze Fatima, Murat Arslan, Simon John Davies, Naveed Ul Haque
A 90-day study was conducted to investigate the effects of substituting sunflower oil (SFO) for fish oil (FO) on various parameters in Labeo rohita (initial weight 18.21 ± 0.22 g). Five experimental diets with different levels of SFO (up to 7%) substitution for FO (0%, 25%, 50%, 75%, and 100%) were formulated, ensuring equal levels of nitrogen and lipids. The results indicated that even with 100% substitution of SFO with FO, there were no significant differences (P>0.05) were observed in growth performance...
2024: PloS One
https://read.qxmd.com/read/38482842/pemafibrate-and-other-triglyceride-lowering-therapies-to-reduce-risk-of-cardiovascular-and-metabolic-disease
#9
JOURNAL ARTICLE
Michael Miller
PURPOSE OF REVIEW: Although high triglycerides are consistently associated with elevated risk of cardiovascular disease (CVD), therapies that reduce triglyceride levels have inconsistently translated into reduced CVD risk. RECENT FINDINGS: To date, three clinical trials have tested triglyceride-lowering therapies in patients with hypertriglyceridemia (HTG) and elevated risk of incident/recurrent CVD. In REDUCE-IT (Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial), assignment to IPE, a highly purified eicosapentanoic acid (EPA), resulted in a 25% reduction in nonfatal myocardial infarction), nonfatal stroke, cardiovascular death, coronary revascularization and hospitalization for unstable angina...
March 6, 2024: Current Opinion in Cardiology
https://read.qxmd.com/read/38482513/association-between-improved-serum-fatty-acid-profiles-and-cognitive-function-during-a-dietary-intervention-trial-in-relapsing-remitting-multiple-sclerosis
#10
JOURNAL ARTICLE
Solange M Saxby, Carlyn Haas, Farnoosh Shemirani, Tyler J Titcomb, Patrick Ten Eyck, Linda M Rubenstein, Karin F Hoth, Linda G Snetselaar, Terry L Wahls
BACKGROUND: Cognitive impairment is a common multiple sclerosis (MS)-related symptom that impacts quality of life (QOL). Diet interventions are shown to be beneficial in managing QOL, and the intake of essential fatty acids is linked with improved cognitive function. However, the effect of diets on serum fatty acid profiles and cognitive function is unknown. METHODS: A previous randomized, parallel-arm trial recruited participants with relapsing-remitting MS (N = 77)...
2024: International Journal of MS Care
https://read.qxmd.com/read/38479498/association-between-eicosapentaenoic-acid-consumption-and-the-risk-of-depressive-symptoms-in-us-adults-analyses-from-nhanes-2005-2018
#11
JOURNAL ARTICLE
Chenxi Zhang, Bingnan Hou, Yan Xu, Shufei Zeng, Xue Luo, Bin Zhang
BACKGROUND: This study examines the relationship between eicosapentaenoic acid (EPA) intake from food and depression. EPA, an Omega-3 fatty acid commonly found in fish and seafood, has garnered attention for its potential role in depression prevention and treatment. METHODS: We selected 30,976 participants from the National Health and Nutrition Examination Survey (NHANES) conducted between 2005 and 2018. Depressive symptoms were diagnosed using the Patient Health Questionnaire (PHQ-9)...
March 11, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38478807/applying-the-2022-cardiovascular-and-pulmonary-entry-level-physical-therapist-competencies-to-physical-therapist-education-and-practice
#12
JOURNAL ARTICLE
Nancy Smith, Angela Campbell, Morgan Johanson, Pamela Bartlo, Naomi Bauer, Sagan Everett
BACKGROUND AND PURPOSE: Competency-based education (CBE) is an emerging topic within physical therapy (PT). It has emerged to assure all stakeholders that physical therapist education program graduates are proficient in the requisite knowledge, skills, and behaviors (KSBs) essential for entry-level practice. Competencies have existed within cardiovascular and pulmonary (CVP) PT since 1980, updated in 2008, and most recently updated in 2022. This article discusses how individuals should apply the 2022 CVP competencies to clinical practice and education...
September 1, 2023: Journal, Physical Therapy Education
https://read.qxmd.com/read/38478065/management-of-inorganic-elements-by-overwintering-physiology-of-cold-hardy-larvae-of-european-corn-borer-ostrinia-nubilalis-hbn
#13
JOURNAL ARTICLE
Elvira L Vukašinović, Željko D Popović, Jordana Ninkov, Tatjana V Čelić, Iva Uzelac, Danijela Kojić, Jelena Purać
The European corn borer (Ostrinia nubilalis, Hbn.), enters diapause, a strategy characterized by arrest of development and reproduction, reduction of metabolic rate and the emergence of increased resistance to challenging seasonal conditions as low sub-zero winter temperatures. The aim of this study was to investigate the potential role of inorganic elements in the ecophysiology of O. nubilalis, analysing their content in the whole body, hemolymph and fat body, both metabolically active, non-diapausing and overwintering diapausing larvae by ICP-OES spectrometer following the US EPA method 200...
March 13, 2024: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://read.qxmd.com/read/38477902/entrustable-professional-activities-in-surgery-a-review
#14
JOURNAL ARTICLE
Kelsey B Montgomery, John D Mellinger, Brenessa Lindeman
IMPORTANCE: Entrustable professional activities (EPAs) compose a competency-based education (CBE) assessment framework that has been increasingly adopted across medical specialties as a workplace-based assessment tool. EPAs focus on directly observed behaviors to determine the level of entrustment a trainee has for a given activity of that specialty. In this narrative review, we highlight the rationale for EPAs in general surgery, describe current evidence supporting their use, and outline some of the practical considerations for EPAs among residency programs, faculty, and trainees...
March 13, 2024: JAMA Surgery
https://read.qxmd.com/read/38476297/early-emergency-medicine-milestone-assessment-for-predicting-first-year-resident-performance
#15
JOURNAL ARTICLE
Rochelle L Versalle, Brett R Todd, Nai-Wei Chen, Danielle E Turner-Lawrence
INTRODUCTION: The Accreditation Council for Graduate Medical Education (ACGME) requires emergency medicine (EM) residency training programs to monitor residents' progress using standardized milestones. The first assessment of PGY 1 resident milestones occurs midway through the first year and could miss initial deficiencies. Early assessment of PGY 1 EM resident milestones has potential to identify at-risk residents prior to standard midyear evaluations. We developed an orientation syllabus for PGY 1 residents followed by a milestone assessment...
2024: MedEdPORTAL Publications
https://read.qxmd.com/read/38474820/developmental-and-nutritional-changes-in-children-with-severe-acute-malnutrition-provided-with-n-3-fatty-acids-improved-ready-to-use-therapeutic-food-and-psychosocial-support-a-pilot-study-in-tanzania
#16
JOURNAL ARTICLE
Fredrick Cyprian Mwita, George PrayGod, Erica Sanga, Theresia Setebe, Gaudensia Joseph, Happyness Kunzi, Jayne Webster, Melissa Gladstone, Rebecca Searle, Maimuna Ahmed, Adolfine Hokororo, Suzanne Filteau, Henrik Friis, André Briend, Mette Frahm Olsen
Children with severe acute malnutrition (SAM) are at high risk of impaired development. Contributing causes include the inadequate intake of specific nutrients such as polyunsaturated fatty acids (PUFAs) and a lack of adequate stimulation. We conducted a pilot study assessing developmental and nutritional changes in children with SAM provided with a modified ready-to-use therapeutic food and context-specific psychosocial intervention in Mwanza, Tanzania. We recruited 82 children with SAM (6-36 months) and 88 sex- and age-matched non-malnourished children...
February 28, 2024: Nutrients
https://read.qxmd.com/read/38474815/the-maternal-omega-3-long-chain-polyunsaturated-fatty-acid-concentration-in-early-pregnancy-and-infant-neurodevelopment-the-eclipses-study
#17
JOURNAL ARTICLE
Behnaz Shahabi, Carmen Hernández-Martínez, Núria Voltas, Josefa Canals, Victoria Arija
Omega-3 Long-Chain Polyunsaturated Fatty Acids ( n -3 LCPUFAs) play a key role in early neurodevelopment, but evidence from observational and clinical studies remains inconsistent. This study investigates the association between maternal n -3 LCPUFA, Docosahexaenoic Acid (DHA), and eicosapentaenoic acid (EPA) concentrations during pregnancy and infant development functioning at 40 days. This study includes 348 mother-infant pairs. Maternal serum concentrations were assessed in the first and third trimesters alongside sociodemographic, clinical, nutritional, psychological, and obstetrical data...
February 28, 2024: Nutrients
https://read.qxmd.com/read/38474148/eicosapentaenoic-acid-modulates-transient-receptor-potential-v1-expression-in-specific-brain-areas-in-a-mouse-fibromyalgia-pain-model
#18
JOURNAL ARTICLE
Hsien-Yin Liao, Chia-Ming Yen, I-Han Hsiao, Hsin-Cheng Hsu, Yi-Wen Lin
Pain is an unpleasant sensory and emotional experience accompanied by tissue injury. Often, an individual's experience can be influenced by different physiological, psychological, and social factors. Fibromyalgia, one of the most difficult-to-treat types of pain, is characterized by general muscle pain accompanied by obesity, fatigue, sleep, and memory and psychological concerns. Fibromyalgia increases nociceptive sensations via central sensitization in the brain and spinal cord level. We used intermittent cold stress to create a mouse fibromyalgia pain model via a von Frey test (day 0: 3...
March 1, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38474135/yeast-derived-nucleotides-enhance-fibroblast-migration-and-proliferation-and-provide-clinical-benefits-in-atopic-dermatitis
#19
JOURNAL ARTICLE
Sergi Segarra, Ivica Bošnjak, Igor Mioč, Bojana Čurčija, Vlatka-Antonija Csik, Srećko Krešić, Jessica Romero-Rueda, Anna Rodríguez, Daniel Martínez-Puig
Nucleotides, glycosaminoglycans, and omega-3 essential fatty acids (O3s) could be used for improving skin health, although their modes of action, alone or in combination, are not yet fully understood. To gain some insight into these mechanisms, we performed two in vitro tests and one in vivo pilot trial. The effects on human dermal fibroblast proliferation and migration were evaluated with the following compounds and combinations: 0.156 mg/mL O3s, 0.0017 mg/mL hyaluronic acid (HA), 0.0004 mg/mL dermatan sulfate (DS), 0...
March 1, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473995/inhibitory-effects-of-eicosapentaenoic-acid-on-vascular-endothelial-growth-factor-induced-monocyte-chemoattractant-protein-1-interleukin-6-and-interleukin-8-in-human-vascular-endothelial-cells
#20
JOURNAL ARTICLE
Yoko Takenoshita, Akinori Tokito, Michihisa Jougasaki
Vascular endothelial growth factor (VEGF) induces monocyte chemoattractant protein-1 (MCP-1) and plays an important role in vascular inflammation and atherosclerosis. We investigated the mechanisms of VEGF-induced MCP-1 expression and the effects of eicosapentaenoic acid (EPA) in human umbilical vein endothelial cells (HUVECs). Real-time reverse transcription polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA) demonstrated that VEGF enhanced MCP-1 gene expression and protein secretion in HUVECs...
February 27, 2024: International Journal of Molecular Sciences
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