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https://www.readbyqxmd.com/read/29040972/regulation-of-coronary-arterial-large-conductance-ca2-activated-k-channel-protein-expression-and-function-by-n-3-polyunsaturated-fatty-acids-in-diabetic-rats
#1
Xu Tang, Ling-Ling Qian, Ru-Xing Wang, Yong Yao, Shi-Peng Dang, Ying Wu, Wen Wang, Yuan Ji, Man-Qing Sun, Da-Yun Xia, Xiao-Yu Liu, Dai-Min Zhang, Qiang Chai, Tong Lu
AIM: The objective of this study was to examine the effects of n-3 polyunsaturated fatty acids (n-3 PUFAs) on coronary arterial large conductance Ca2+-activated K+ (BK) channel function in coronary smooth muscle cells (SMCs) of streptozotocin-induced diabetic rats. METHODS: The effects of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on coronary BK channel open probabilities were determined using the patch clamp technique. The mRNA and protein expressions of BK channel subunits were measured using qRT-PCR and Western blots...
October 18, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/29040439/eicosapentaenoic-acid-attenuates-obesity-related-hepatocellular-carcinogenesis
#2
Akane Inoue-Yamauchi, Hiroko Itagaki, Hideaki Oda
Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of obesity, is an emerging risk factor for hepatocellular carcinoma (HCC). Accumulating evidence has shown that chronic inflammation represents a plausible link between obesity and HCC, and that the pro-inflammatory cytokine IL-6 contributes to the development of obesity-related HCC. In the present study, we aimed to examine the therapeutic potential of the omega-3 polyunsaturated fatty acid, eicosapentaenoic acid (EPA), which exerts anti-inflammatory effects...
October 12, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29039280/very-long-chain-n-3-fatty-acids-and-human-health-fact-fiction-and-the-future
#3
P C Calder
EPA and DHA appear to be the most important n-3 fatty acids, but roles for n-3 docosapentaenoic acid are now also emerging. Intakes of EPA and DHA are usually low, typically below those recommended. Increased intakes result in higher concentrations of EPA and DHA in blood lipids, cells and tissues. Increased content of EPA and DHA modifies the structure of cell membranes and the function of membrane proteins. EPA and DHA modulate the production of lipid mediators and through effects on cell signalling can alter the patterns of gene expression...
October 17, 2017: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/29037249/a-novel-self-micro-emulsifying-delivery-system-smeds-formulation-significantly-improves-the-fasting-absorption-of-epa-and-dha-from-a-single-dose-of-an-omega-3-ethyl-ester-concentrate
#4
Yan Qin, Hilde Nyheim, Else Marie Haram, Joseph M Moritz, Svein Olaf Hustvedt
BACKGROUND: Absorption of EPA and DHA from Omega-3-acid ethyl ester (EE) concentrate supplements occurs most efficiently when taken in context of a fatty meal; adequate fat intake is required to release bile salts that emulsify and pancreatic enzymes that digest omega-3-containing lipids in the intestine. Current guidelines recommend reduction in fat intake and therefore there is a need to optimize the absorption of Omega-3 in those consuming low-fat or no-fat meals. To this end, BASF has developed an Absorption Acceleration Technology, a novel self-micro-emulsifying delivery system (SMEDS) formulation of highly concentrated Omega-3-acid EE which enables rapid emulsification and microdroplet formation upon entering the aqueous environment of the gut therefore enhances the absorption...
October 16, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29035816/docosahexaenoic-acid-attenuates-carbon-tetrachloride-induced-hepatic-fibrosis-in-rats
#5
Jianlin He, Kaikai Bai, Bihong Hong, Feng Zhang, Shizhong Zheng
Fish oil containing docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) has been reported to exert beneficial health effects, including hepatoprotection. However, the effect of DHA alone has not been well studied, and the mechanism is not fully understood. In the present study, we reported the protective effect of DHA on carbon tetrachloride (CCl4) induced hepatic fibrosis. Compared with the control group, the CCl4 group showed hepatic damage as evidenced by histological changes and elevation in serum transaminase activity, fibrosis, inflammation and oxidative stress levels...
October 13, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29034644/the-effect-of-eicosapentaenoic-acid-on-the-serum-levels-and-enzymatic-activity-of-paraoxonase-1-in-the-patients-with-type-2-diabetes-mellitus
#6
Mohammad Hassan Golzari, Saeed Hosseini, Fariba Koohdani, Ali-Akbar Saboor Yaraghi, Mohammad Hassan Javanbakht, Niyaz Mohammadzadeh-Honarvar, Mahmoud Djalali
Paraoxonase 1 is known as one of the most important ant oxidative enzymes associated with HDL-c, and because of its antioxidant and antiinflammatory activities. EPA has the antioxidant, anti inflammatory, antithrombogenic, and antiarteriosclerotic properties. Therefore, we investigated the effect of EPA supplementation on the serum levels and activity of PON1 in type 2 diabetic patients. This study was designed as a randomized, double-blind, and placebo-controlled clinical trial. Thirty-six patients with type 2 diabetes were given written; informed consent randomly was classified into 2 groups...
August 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29033206/pediatric-environmental-health-using-data-on-toxic-chemical-emissions-in-practice
#7
Kara Koehrn, Jocelyn Hospital, Alan Woolf, Jennifer Lowry
Children's unique behavioral and physiological characteristics can increase their exposure and susceptibility to environmental chemicals. The link between exposure to environmental chemicals and specific health outcomes, however, is often uncertain. This article introduces several resources to help health practitioners identify potential environmental exposures and risks related to toxic chemicals. It focuses on the U.S. Environmental Protection Agency's (EPA's) free and public environmental data, including the Toxics Release Inventory (TRI) data that contain information about toxicants released to the environment...
October 12, 2017: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/29031899/synapse-formation-in-the-brain-can-be-enhanced-by-co-administering-three-specific-nutrients
#8
Richard J Wurtman
The memory impairments of early Alzheimer's disease [AD] are thought to result from a deficiency in synapses within the hippocampus and related brain regions. This deficiency could result from an acceleration in synapse turnover - perhaps caused by an endogenous neurotoxin like A-beta oligomers - or from a decrease in the production of the synaptic membrane needed to form new synapses. An AD-associated decrease in synaptogenesis almost certainly does occur, inasmuch as major decreases are also observed in the numbers of hippocampal dendritic spines, the immediate cytologic precursor of glutamatergic synapses...
October 11, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29031402/associations-between-maternal-long-chain-polyunsaturated-fatty-acid-concentrations-and-child-cognition-at-7-years-of-age-the-mefab-birth-cohort
#9
E M Brouwer-Brolsma, O van de Rest, R Godschalk, M P A Zeegers, M Gielen, R H M de Groot
INTRODUCTION: Concentrations of the fish fatty acids EPA and DHA are low among Dutch women of reproductive age. As the human brain incorporates high concentrations of these fatty acids in utero, particularly during third trimester of gestation, these low EPA and DHA concentrations may have adverse consequences for fetal brain development and functioning. METHODS: Analyses were conducted using longitudinal observational data of 292 mother-child pairs participating in the MEFAB cohort...
November 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29031392/effects-of-aspirin-in-combination-with-epa-and-dha-on-hdl-c-cholesterol-and-apoa1-exchange-in-individuals-with-type-2-diabetes-mellitus
#10
Robert C Block, Ashley Holub, Amir Abdolahi, Xin M Tu, Shaker A Mousa, Michael N Oda
BACKGROUND/SYNOPSIS: Low-dose aspirin is an effective drug for the prevention of cardiovascular disease (CVD) events but individuals with diabetes mellitus can be subject to 'aspirin resistance'. Thus, aspirin's effect in these individuals is controversial. Higher blood levels of seafood-derived omega-3 polyunsaturated fatty acids (ω3) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) also have beneficial effects in reducing risk of CVD events but few studies have examined the interaction of plasma EPA and DHA with aspirin ingestion...
November 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29031390/effects-of-postnatal-omega-3-fatty-acid-supplementation-on-offspring-pro-resolving-mediators-of-inflammation-at-6-months-and-5-years-of-age-a-double-blind-randomized-controlled-clinical-trial
#11
V H L See, E Mas, S L Prescott, L J Beilin, S Burrows, A E Barden, R C Huang, T A Mori
BACKGROUND: Resolution of inflammation is an active process involving specialised pro-resolving mediators (SPMs) generated from the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Omega-3 fatty acid supplementation during infancy may provide an intervention strategy to modify SPMs and reduce oxidative stress. This study evaluates the effect of omega-3 fatty acid supplementation in infancy on SPMs and F2-isoprostanes from 6 months to 5 years of age. METHODS: In a double-blind, placebo-controlled, parallel-group study design, 420 infants were randomized to a daily supplement of omega-3 fatty acids (280mg DHA and 110mg EPA) or olive oil (control), from birth to age 6 months...
November 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29031215/comprehensive-multipathway-risk-assessment-of-chemicals-associated-with-recycled-crumb-rubber-in-synthetic-turf-fields
#12
Michael K Peterson, Julie C Lemay, Sara Pacheco Shubin, Robyn L Prueitt
BACKGROUND: Thousands of synthetic turf fields in the US are regularly used by millions of individuals (particularly children and adolescents). Although many safety assessments have concluded that there are low or negligible risks related to exposure to chemicals found in the recycled rubber used to make these fields, concerns remain about the safety of this product. Existing studies of recycled rubber's potential health risks have limitations such as small sample sizes and limited evaluation of relevant exposure pathways and scenarios...
October 11, 2017: Environmental Research
https://www.readbyqxmd.com/read/29030883/polyunsaturated-fatty-acids-influence-inflammatory-markers-in-a-cellular-model-for-canine-osteoarthritis
#13
N Adler, A Schoeniger, H Fuhrmann
Although it is well recognized that dietary supplementation with fish oil improves clinical symptoms in dogs suffering from osteoarthritis, the molecular basis for the dietary benefit is not yet completely resolved in dogs. This study was designed to further clarify how polyunsaturated fatty acids (PUFA) affect key factors of cartilage degeneration in a canine cell culture system mimicking osteoarthritis. Canine chondrocytes were incubated either without or with 10 μm of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), arachidonic acid (AA) or 3...
October 13, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29030616/maternal-consumption-of-fish-oil-programs-reduced-adiposity-in-broiler-chicks
#14
Ronique C Beckford, Sarah J Howard, Suchita Das, Abigail T Farmer, Shawn R Campagna, Jiali Yu, Robert L Hettich, Jeanna L Wilson, Brynn H Voy
Maternal intake of eicosapentaenoic acid (EPA; 20:5 n-3) and docosahexaenoic acid (22:6 n-3) has been associated with reduced adiposity in children, suggesting the possibility to program adipose development through dietary fatty acids before birth. This study determined if enriching the maternal diet in fish oil, the primary source of EPA and DHA, affected adipose development in offspring. Broiler chickens were used because they are obesity-prone, and because fatty acids provided to the embryo can be manipulated through the hen diet...
October 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29029736/rapid-visual-and-spectrophotometric-nitrite-detection-by-cyclometalated-ruthenium-complex
#15
Hoi-Shing Lo, Ka-Wai Lo, Chi-Fung Yeung, Chun-Yuen Wong
Quantitative determination of nitrite ion (NO2(-)) is of great importance in environmental and clinical investigations. A rapid visual and spectrophotometric assay for NO2(-) detection was developed based on a newly designed ruthenium complex, [Ru(npy)([9]aneS3)(CO)](ClO4) (denoted as RuNPY; npy = 2-(1-naphthyl)pyridine, [9]aneS3 = 1,4,7-trithiacyclononane). This complex traps NO(+) produced in acidified NO2(-) solution, and yields observable color change within 1 min at room temperature. The assay features excellent dynamic range (1-840 μmol L(-1)) and high selectivity, and its limit of detection (0...
October 16, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29029043/degradation-of-the-recalcitrant-oil-spill-components-anthracene-and-pyrene-by-a-microbially-driven-fenton-reaction
#16
Ramanan Sekar, Thomas J DiChristina
Oil spill components include a range of toxic saturated, aromatic, and polar hydrocarbons, including pyrene and anthracene. Such contaminants harm natural ecosystems, adversely affect human health, and negatively impact tourism and the fishing industries. Current physical, chemical, and biological remediation technologies are often unable to completely remove recalcitrant oil spill components, which accumulate at levels greater than regulatory limits set by the EPA. In the present study, a microbially-driven Fenton reaction, previously shown to produce hydroxyl (HO) radicals that degrade chlorinated solvents and associated solvent stabilizers, was also found to degrade source zone concentrations of the oil spill components pyrene (10 μM) and anthracene (1 μM) at initial rates of 0...
September 25, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29026429/markers-of-neuroprotection-of-combined-epa-and-dha-provided-by-fish-oil-are-higher-than-those-of-epa-nannochloropsis-and-dha-schizochytrium-from-microalgae-oils-in-wistar-rats
#17
Paula A Lopes, Narcisa M Bandarra, Susana V Martins, Joana Martinho, Cristina M Alfaia, Marta S Madeira, Carlos Cardoso, Cláudia Afonso, Maria C Paulo, Rui M A Pinto, José L Guil-Guerrero, José A M Prates
BACKGROUND: To overcome the current overexploitation of fish rich in n-3 long chain polyunsaturated fatty acids (LCPUFA), microalgae have become a promising marine lipid source. The purpose of this study was to assess eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3), isolated or combined from distinct marine origins, on the promotion of neuroprotective effects. METHODS: The experiment lasted for 10 weeks and involved 32 Wistar rats, divided into 4 diets (n = 8): a diet rich in milk fat was taken as control (Milk Fat) and compared to n-3 LCPUFA enriched diets, either in EPA + DHA form through fish oil (Fish Oil), or EPA through Nannochloropsis oil (Nanno), or DHA through Schizochytrium oil (Schyzo), while maintaining Milk Fat incorporation...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29023038/evaluation-of-autothermal-thermophilic-aerobic-digester-performance-for-the-stabilization-of-municipal-wastewater-sludge
#18
Reza Shokoohi, Alireza Rahmani, Ghorban Asgari, Abdollah Dargahi, Yaser Vaziri, Mohammad Attar Abbasi
BACKGROUND AND OBJECTIVE: Sludge stabilization process in terms of operational, environmental and economic indexes is the most important stage of treatment and its disposal. This study was aimed to determine the performance of Autothermal Thermophilic Aerobic Digestion (ATAD) system as one of the low-cost and biocompatible methods of sludge treatment. MATERIALS AND METHODS: This study has been done using a laboratory scale Autothermal Thermophilic Aerobic Digestion (ATAD)...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/29019666/airborne-methane-emission-measurements-for-selected-oil-and-gas-facilities-across-california
#19
Shobhit Mehrotra, Ian C Faloona, Maxime Suard, Stephen A Conley, Marc L Fischer
We report 65 individual measurements of methane emissions from 24 oil & gas facilities across California. Methane emission rates were estimated using in-situ methane and wind velocity measurements from a small aircraft by a novel Gauss' Theorem flux integral approach. The estimates are compared with annual mean emissions reported to the US-EPA and the California Air Resources Board (CARB) through their respective greenhouse gas reporting programs. The average emissions from 36 measurements of 10 gas storage facilities were within a factor of 2 of emissions reported to US-EPA or CARB, though large variance was observed and the reporting database did not contain all of the facilities...
October 11, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29017063/european-status-and-perspectives-on-early-detection-and-intervention-in-at-risk-mental-state-and-first-episode-psychosis-viewpoint-from-the-epa-section-for-prevention-of-mental-disorders
#20
EDITORIAL
N P Maric, A Raballo, M Rojnic Kuzman, S Andric Petrovic, J Klosterkötter, A Riecher-Rössler
No abstract text is available yet for this article.
September 8, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
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