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https://www.readbyqxmd.com/read/27919677/an-individual-differences-approach-to-multiple-target-visual-search-errors-how-search-errors-relate-to-different-characteristics-of-attention
#1
Stephen H Adamo, Matthew S Cain, Stephen R Mitroff
Multiple-target visual searches, where more than one target can be present within a single search array, are especially error-prone such that a second target is more likely to be missed after a first target has been detected. Increasingly, evidence supports a resource depletion account of these errors-a first target consumes attentional resources leaving fewer available to process a second target. However, "attention" is broadly defined and is composed of many different characteristics, leaving considerable uncertainty about how attention affects second-target detection...
December 2, 2016: Vision Research
https://www.readbyqxmd.com/read/27909379/-it-is-an-eye-opener-that-there-is-a-relationship-between-rehabilitation-and-hiv-perspectives-of-physiotherapists-and-occupational-therapists-in-kenya-and-zambia-on-the-role-of-rehabilitation-with-adults-and-children-living-with-hiv
#2
Stephanie Nixon, Cathy Cameron, Margaret Mweshi, Esther Munalula Nkandu, Carlius Okidi, Stephen Tattle, Tammy Yates
Purpose: To present the perspectives of rehabilitation providers-physiotherapists and occupational therapists-in Kenya and Zambia on the role of rehabilitation in the care of adults and children living with HIV. Methods: This qualitative, interpretivist study was part of a broader project to adapt a Canadian e-module on HIV-related disability for rehabilitation providers in Sub-Saharan Africa (SSA). Focus groups, demographic questionnaires, and knowledge-attitude-belief surveys were conducted with rehabilitation providers in Kenya and Zambia...
2016: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/27887620/anatomy-meets-dentistry-linking-anatomy-and-clinical-practice-in-the-preclinical-dental-curriculum
#3
Nicole Rafai, Martin Lemos, Lieven Nils Kennes, Ayichah Hawari, Susanne Gerhardt-Szép, Irmgard Classen-Linke
BACKGROUND: Establishing a strong link early on between preclinical coursework and the clinical context is necessary for students to be able to recognize the practical relevance of the curriculum during their preclinical anatomical courses and to transfer knowledge more easily. Our objective was to enhance the clinical relevance of a preclinical anatomy course for second-year medical students of dentistry by implementing an interdisciplinary skills training course on "Palpation of the Head and Neck Muscles" and to measure the learning outcomes...
November 25, 2016: BMC Medical Education
https://www.readbyqxmd.com/read/27550846/orf-virus-interleukin-10-and-vascular-endothelial-growth-factor-e-modulate-gene-expression-in-cultured-equine-dermal-fibroblasts
#4
Lyn M Wise, Christa J Bodaan, Andrew A Mercer, Christopher B Riley, Christine L Theoret
BACKGROUND: Wounds in horses often exhibit sustained inflammation and inefficient vascularization, leading to excessive fibrosis and clinical complications such as "proud flesh". Orf virus-derived proteins, vascular endothelial growth factor (VEGF)-E and interleukin (ovIL)-10, enhance angiogenesis and control inflammation and fibrosis in skin wounds of laboratory animals. HYPOTHESIS/OBJECTIVES: The study aimed to determine if equine dermal cells respond to VEGF-E and ovIL-10...
October 2016: Veterinary Dermatology
https://www.readbyqxmd.com/read/27458137/vitamin-d-enhances-the-efficacy-of-irinotecan-through-mir-627-mediated-inhibition-of-intratumoral-drug-metabolism
#5
Meiyan Sun, Qunshu Zhang, Xiaoyu Yang, Steven Y Qian, Bin Guo
Cytochrome P450 enzyme CYP3A4 is an important drug-metabolizing enzyme, and high levels of tumoral expression of CYP3A4 are linked to drug resistance. We investigated the function of vitamin D-regulated miR-627 in intratumoral CYP3A4 suppression and its role in enhancing the efficacy of chemotherapy. We found that miR-627 targets CYP3A4 and suppresses CYP3A4 expression in colon cancer cell lines. Furthermore, calcitriol (the active form of vitamin D) suppressed CYP3A4 expression by activating miR-627. As a result, calcitriol inhibited CYP3A4-mediated metabolism of irinotecan (a topoisomerase I inhibitor) in cancer cells...
September 2016: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/27100104/functional-assessment-of-synoptic-pathology-reporting-for-ovarian-cancer
#6
Janina Słodkowska, Szczepan Cierniak, Janusz Patera, Jarosław Kopik, Włodzimierz Baranowski, Tomasz Markiewicz, Piotr Murawski, Irmina Buda, Wojciech Kozłowski
BACKGROUND: Ovarian cancer has one of the highest death/incidence rates and is commonly diagnosed at an advanced stage. In the recent WHO classification, new histotypes were classified which respond differently to chemotherapy. The e-standardized synoptic cancer pathology reports offer the clinicians essential and reliable information. The aim of our project was to develop an e-template for the standardized synoptic pathology reporting of ovarian carcinoma [based on the checklist of the College of American Pathologists (CAP) and the recent WHO/FIGO classification] to introduce a uniform and improved quality of cancer pathology reports...
2016: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/27049072/is-vitamin-e-an-anti-allergic-compound
#7
A L Caraffa, G Varvara, E Spinas, S K Kritas, G Lessiani, G Ronconi, A Saggini, P Antinolfi, I Frydas, M C De Tommaso Morrison, P Conti
Vitamin E is found in eight forms in nature which include four tocopherols (alpha, beta, gamma and delta) and four tocotrianols (alpha, beta, gamma and delta). The classic effect of vitamin E is to reduce and prevent oxygen damage to the tissue and is useful for the treatment of pain, inflammation and allergic reactions. In addition to antioxidant activity, vitamin E also has a number of different and related functions. It protects against cancer, improves immune response, lowers the incidence of infectious diseases, cardiovascular diseases and is protective in allergy and asthma risk, and other disorders...
January 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/26994660/auditory-steady-state-responses-in-cochlear-implant-users-effect-of-modulation-frequency-and-stimulation-artifacts
#8
Robin Gransier, Hanne Deprez, Michael Hofmann, Marc Moonen, Astrid van Wieringen, Jan Wouters
Previous studies have shown that objective measures based on stimulation with low-rate pulse trains fail to predict the threshold levels of cochlear implant (CI) users for high-rate pulse trains, as used in clinical devices. Electrically evoked auditory steady-state responses (EASSRs) can be elicited by modulated high-rate pulse trains, and can potentially be used to objectively determine threshold levels of CI users. The responsiveness of the auditory pathway of profoundly hearing-impaired CI users to modulation frequencies is, however, not known...
May 2016: Hearing Research
https://www.readbyqxmd.com/read/26869535/the-effectiveness-of-e-learning-in-pediatric-medical-student-education
#9
Rima Khasawneh, Kari Simonsen, Jessica Snowden, Joy Higgins, Gary Beck
BACKGROUND: Electronic learning allows individualized education and may improve student performance. This study assessed the impact of e-modules about infection control and congenital infections on medical knowledge. METHODS: A descriptive study was conducted involving third-year medical students on pediatric clerkship. e-Module content in three different formats was developed: a text monograph, a PowerPoint presentation, and a narrated PowerPoint lecture. Students' use of the e-modules was tracked, as was participation in the infectious disease rotation and the order of pediatric rotation...
2016: Medical Education Online
https://www.readbyqxmd.com/read/26768589/the-effect-of-an-interactive-delirium-e-learning-tool-on-healthcare-workers-delirium-recognition-knowledge-and-strain-in-caring-for-delirious-patients-a-pilot-pre-test-post-test-study
#10
COMPARATIVE STUDY
Elke Detroyer, Fabienne Dobbels, Deborah Debonnaire, Kate Irving, Andrew Teodorczuk, Donna M Fick, Etienne Joosten, Koen Milisen
BACKGROUND: Studies investigating the effectiveness of delirium e-learning tools in clinical practice are scarce. The aim of this study is to determine the effect of a delirium e-learning tool on healthcare workers' delirium recognition, delirium knowledge and care strain in delirium. METHODS: A pilot pre-posttest study in a convenience sample of 59 healthcare workers recruited from medical, surgical, geronto-psychiatric and rehabilitation units of a university hospital...
January 15, 2016: BMC Medical Education
https://www.readbyqxmd.com/read/26588426/curricular-response-to-increase-recall-and-transfer-of-anatomical-knowledge-into-the-obstetrics-gynecology-clerkship
#11
Rosalyn A Jurjus, Kirsten Brown, Ellen Goldman, Artin Galoosian, Gisela Butera, Jill M Krapf
Deficits in retention of anatomy knowledge from the preclinical years to clinical application on the wards have been well documented in the medical education literature. We developed and evaluated a web and laboratory-based curriculum to address deficits in anatomy knowledge retention and to increase anatomy knowledge recall through repetition and application of clinical concepts during the obstetrics and gynecology (Ob/Gyn) core clinical clerkship. Using principles of adult learning and instructional design, a curriculum was designed consisting of (1) interactive, case-based e-modules reviewing clinically relevant anatomical topics and (2) a hands-on laboratory session reinforcing the content of the e-modules, with the practice of clinical techniques using anatomical cadaveric dissections...
July 8, 2016: Anatomical Sciences Education
https://www.readbyqxmd.com/read/26433730/an-experimental-study-on-the-effects-of-a-simulation-game-on-students-clinical-cognitive-skills-and-motivation
#12
Mary E W Dankbaar, Jelmer Alsma, Els E H Jansen, Jeroen J G van Merrienboer, Jan L C M van Saase, Stephanie C E Schuit
Simulation games are becoming increasingly popular in education, but more insight in their critical design features is needed. This study investigated the effects of fidelity of open patient cases in adjunct to an instructional e-module on students' cognitive skills and motivation. We set up a three-group randomized post-test-only design: a control group working on an e-module; a cases group, combining the e-module with low-fidelity text-based patient cases, and a game group, combining the e-module with a high-fidelity simulation game with the same cases...
August 2016: Advances in Health Sciences Education: Theory and Practice
https://www.readbyqxmd.com/read/26393138/evaluation-of-students-perceptions-towards-an-innovative-teaching-learning-method-during-pharmacology-revision-classes-autobiography-of-drugs
#13
Anuradha Joshi, Jaishree Ganjiwale
INTRODUCTION: Various studies in medical education have shown that active learning strategies should be incorporated into the teaching-learning process to make learning more effective, efficient and meaningful. OBJECTIVES: The aim of this study was to evaluate student's perceptions on an innovative revision method conducted in Pharmacology i.e. in form of Autobiography of Drugs. The main objective of study was to help students revise the core topics in Pharmacology in an interesting way...
July 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26391391/genes-affecting-%C3%AE-cell-function-in-type-1-diabetes
#14
REVIEW
Tina Fløyel, Simranjeet Kaur, Flemming Pociot
Type 1 diabetes (T1D) is a multifactorial disease resulting from an immune-mediated destruction of the insulin-producing pancreatic β cells. Several environmental and genetic risk factors predispose to the disease. Genome-wide association studies (GWAS) have identified around 50 genetic regions that affect the risk of developing T1D, but the disease-causing variants and genes are still largely unknown. In this review, we discuss the current status of T1D susceptibility loci and candidate genes with focus on the β cell...
November 2015: Current Diabetes Reports
https://www.readbyqxmd.com/read/26390678/performance-and-safety-of-an-integrated-portable-extracorporeal-life-support-system-for-adults
#15
Cory M Alwardt, Donald S Wilson, Michelle L Alore, Louis A Lanza, Patrick A Devaleria, Octavio E Pajaro
Extracorporeal membrane oxygenation (ECMO) is indicated when conventional measures fail to support a patient during cardiac or respiratory failure. Due to the complicated nature of ECMO, patients often require transport to a tertiary care center. This study retrospectively compared the performance of the Cardiohelp™ (Maquet) life support system with a previously used ECMO circuit when transporting adult patients on venoarterial ECMO between facilities. Two ECMO circuits were compared for performance: 1) the Cardiohelp™ (Maquet) life support system and 2) the "standard" circuit consisting of a Thoratec CentriMag centrifugal pump, Maquet Quadrox-D oxygenator, and a Terumo CDI-500 in-line blood gas analyzer...
March 2015: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/26390379/adverse-childhood-experiences-and-adult-health-outcomes-among-veteran-and-non-veteran-women
#16
COMPARATIVE STUDY
Heather L McCauley, John R Blosnich, Melissa E Dichter
BACKGROUND: Women veterans represent a vulnerable population with unique health needs and disparities in access to care. One constellation of exposures related to subsequent poor health includes adverse childhood experiences (ACEs; e.g., physical and sexual child abuse), though research on impacts of ACEs among women veterans is limited. METHODS: Data were drawn from the 2010 Behavioral Risk Factor Surveillance System for the 11 states that included the ACE module (n=36,485)...
September 2015: Journal of Women's Health
https://www.readbyqxmd.com/read/26390342/chemoproteomics-reveals-novel-protein-and-lipid-kinase-targets-of-clinical-cdk4-6-inhibitors-in-lung-cancer
#17
Natalia J Sumi, Brent M Kuenzi, Claire E Knezevic, Lily L Remsing Rix, Uwe Rix
Several selective CDK4/6 inhibitors are in clinical trials for non-small cell lung cancer (NSCLC). Palbociclib (PD0332991) is included in the phase II/III Lung-MAP trial for squamous cell lung carcinoma (LUSQ). We noted differential cellular activity between palbociclib and the structurally related ribociclib (LEE011) in LUSQ cells. Applying an unbiased mass spectrometry-based chemoproteomics approach in H157 cells and primary tumor samples, we here report distinct proteome-wide target profiles of these two drug candidates in LUSQ, which encompass novel protein and, for palbociclib only, lipid kinases...
December 18, 2015: ACS Chemical Biology
https://www.readbyqxmd.com/read/26390287/grade-of-eosinophilia-versus-symptoms-in-patients-with-dysphagia-and-esophageal-eosinophilia
#18
H Larsson, E Norder Grusell, B Tegtmeyer, M Ruth, H Bergquist, M Bove
The aim of this study was to assess whether the symptom severity and health-related quality of life (HRQL) of patients with dysphagia and esophageal eosinophilia correlate with disease activity as expressed by the number of eosinophils in the esophageal mucosa. This study included newly diagnosed (n = 58) or relapsed patients (n = 7), where 40% were diagnosed in connection with esophageal bolus impaction. The mean age was 45 years (19-88), and 74% were men. Symptoms and HRQL were recorded using the Watson Dysphagia Scale (WDS), the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire - Oesophageal Module 18 and the Short Form-36 Questionnaire...
November 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/26390266/attentional-bias-for-positive-emotional-stimuli-a-meta-analytic-investigation
#19
Eva Pool, Tobias Brosch, Sylvain Delplanque, David Sander
Despite an initial focus on negative threatening stimuli, researchers have more recently expanded the investigation of attentional biases toward positive rewarding stimuli. The present meta-analysis systematically compared attentional bias for positive compared with neutral visual stimuli across 243 studies (N = 9,120 healthy participants) that used different types of attentional paradigms and positive stimuli. Factors were tested that, as postulated by several attentional models derived from theories of emotion, might modulate this bias...
January 2016: Psychological Bulletin
https://www.readbyqxmd.com/read/26390092/evaluation-of-readministration-of-a-recombinant-adeno-associated-virus-vector-expressing-acid-alpha-glucosidase-in-pompe-disease-preclinical-to-clinical-planning
#20
Manuela Corti, Brian Cleaver, Nathalie Clément, Thomas J Conlon, Kaitlyn J Faris, Gensheng Wang, Janet Benson, Alice F Tarantal, Davis Fuller, Roland W Herzog, Barry J Byrne
A recombinant serotype 9 adeno-associated virus (rAAV9) vector carrying a transgene that expresses codon-optimized human acid alpha-glucosidase (hGAA, or GAA) driven by a human desmin (DES) promoter (i.e., rAAV9-DES-hGAA) has been generated as a clinical candidate vector for Pompe disease. The rAAV9-DES-hGAA vector is being developed as a treatment for both early- and late-onset Pompe disease, in which patients lack sufficient lysosomal alpha-glucosidase leading to glycogen accumulation. In young patients, the therapy may need to be readministered after a period of time to maintain therapeutic levels of GAA...
September 2015: Human Gene Therapy. Clinical Development
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