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https://www.readbyqxmd.com/read/28728565/identification-of-differential-co-expressed-gene-networks-in-early-rheumatoid-arthritis-achieving-sustained-drug-free-remission-after-treatment-with-a-tocilizumab-based-or-methotrexate-based-strategy
#1
Xavier M Teitsma, Johannes W G Jacobs, Michal Mokry, Michelle E A Borm, Attila Pethö-Schramm, Jacob M van Laar, Johannes W J Bijlsma, Floris P J Lafeber
BACKGROUND: Methotrexate is endorsed to be used as first-line treatment in rheumatoid arthritis (RA). However, a large proportion of patients need additional treatment with a biological disease-modifying anti-rheumatic drug (DMARD) to adequately suppress their disease activity. A better understanding of genotypes could help to distinguish between patients with different pathogenic mechanisms. The aim of this study was therefore to identify networks of genes within DMARD-naive early RA patients associated with achieving sustained drug-free remission (sDFR) after initiating tocilizumab plus methotrexate, tocilizumab, or methotrexate therapy...
July 20, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28691002/how-do-masters-of-public-health-programs-teach-monitoring-and-evaluation
#2
Himanshu Negandhi, Preeti Negandhi, Sanjay P Zodpey, Hemali Kulatilaka, Radhika Dayal, Lauren J Hart, Marybeth Grewe
INTRODUCTION: The health systems in developing countries face challenges because of deficient monitoring and evaluation (M&E) capacity with respect to their knowledge, skills, and practices. Strengthening M&E training in public health education can help overcome the gaps in M&E capacity. There is a need to advance the teaching of M&E as a core element of public health education. OBJECTIVES: To review M&E teaching across Masters of Public Health programs and to identify core competencies for M&E teaching in South Asian context...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28672782/vitamin-e-and-alzheimer-s-disease-is-it-time-for-personalized-medicine
#3
REVIEW
Breana Cervantes, Lynn M Ulatowski
For the last two decades, it has been hotly debated whether vitamin E-the major lipid-soluble antioxidant, which functions to maintain neurological integrity-is efficacious as a therapy for Alzheimer's disease. Several factors key to the debate, include (1) which of the eight naturally-occurring vitamin E forms should be used; (2) how combination treatments affect vitamin E efficacy; and (3) safety concerns that most-recently resurfaced after the results of the Selenium and vitamin E Cancer prevention trial SELECT prostate cancer trial...
June 24, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28659481/hepatitis-c-virus-strain-dependent-usage-of-apolipoprotein-e-modulates-assembly-efficiency-and-specific-infectivity-of-secreted-virions
#4
Romy Weller, Kathrin Hueging, Richard J P Brown, Daniel Todt, Sebastian Joecks, Florian W R Vondran, Thomas Pietschmann
Hepatitis C virus (HCV) is extraordinarily diverse and uses entry factors in a strain-specific manner. Virus particles associate with lipoproteins and Apolipoprotein E (ApoE) is critical for HCV assembly and infectivity. However, whether ApoE-dependency is common to all HCV genotypes remains unknown. Therefore, we compared the role of ApoE utilizing ten virus strains from genotypes 1 through 7. ApoA and ApoC also support HCV assembly, so they may contribute to virus production in a strain-dependent fashion...
June 28, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28630745/correlation-between-hox-code-and-vertebral-morphology-in-the-mouse-towards-a-universal-model-for-synapsida
#5
Christine Böhmer
BACKGROUND: The importance of the cervical vertebrae as part of the skull-neck system in facilitating the success and diversity of tetrapods is clear. The reconstruction of its evolution, however, is problematic because of the variation in the number of vertebrae, making it difficult to identify homologous elements. Quantification of the morphological differentiation in the neck of diverse archosaurs established homologous units of vertebrae (i.e. modules) resulting from Hox gene expression patterns within the cervical vertebral column...
2017: Zoological Letters
https://www.readbyqxmd.com/read/28585365/tracking-a-century-of-changes-in-microbial-eukaryotic-diversity-in-lakes-driven-by-nutrient-enrichment-and-climate-warming
#6
Eric Capo, Didier Debroas, Fabien Arnaud, Marie-Elodie Perga, Cécile Chardon, Isabelle Domaizon
High-throughput sequencing of sedimentary DNA (sed-DNA) was utilized to reconstruct the temporal dynamics of microbial eukaryotic communities (MECs) at a centennial scale in two re-oligotrophicated lakes that were exposed to different levels of phosphorus enrichment. The temporal changes within the MECs were expressed in terms of richness, composition and community structure to investigate their relationships with two key forcing factors (i.e., nutrient enrichment and climate warming). Various groups, including Apicomplexa, Cercozoa, Chrysophyceae, Ciliophora, Chlorophyceae and Dinophyceae, responded to phosphorus enrichment levels with either positive or negative impacts on their richness and relative abundance...
June 5, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28436703/in-the-driver-s-seat-development-and-implementation-of-an-e-learning-module-on-return-to-driving-after-stroke
#7
Janet Frith, Isobel Hubbard, Carole James, Helen Warren-Forward
Gaps exist in the knowledge of return-to-driving guidelines, and education is needed for Australian health professionals working in the field of stroke. In this paper, authors evaluate the implementation of an e-learning module. A pre- and post-module knowledge test and survey were used to assess the e-module's success in achieving its learning objectives. Initially, 204 learners completed the module, with 68% of learners scoring 100% in the post-module knowledge test. Only 12 learners completed the survey...
April 2017: Occupational Therapy in Health Care
https://www.readbyqxmd.com/read/28368514/vitamin-d-receptor-dependent-signaling-protects-mice-from-dextran-sulfate-sodium-induced-colitis
#8
Fa Wang, Robert L Johnson, Marsha L DeSmet, Paul W Snyder, Keke C Fairfax, James C Fleet
Low vitamin D status potentiates experimental colitis, but the vitamin D-responsive cell in colitis has not been defined. We hypothesized that vitamin D has distinct roles in colonic epithelial cells and in nonepithelial cells during colitis. We tested this hypothesis by using mice with vitamin D receptor (VDR) deletion from colon epithelial cells (CEC-VDRKO) or nonintestinal epithelial cells (NEC-VDRKO). Eight-week-old mice were treated with 1.35% dextran sulfate sodium (DSS) for 5 days and then euthanized 2 or 10 days after removal of DSS...
June 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28360848/response-modality-specific-encoding-of-human-choices-in-upper-beta-band-oscillations-during-vibrotactile-comparisons
#9
Jan Herding, Simon Ludwig, Felix Blankenburg
Perceptual decisions based on the comparison of two vibrotactile frequencies have been extensively studied in non-human primates. Recently, we obtained corresponding findings from human oscillatory electroencephalography (EEG) activity in the form of choice-selective modulations of upper beta band amplitude in medial premotor areas. However, the research in non-human primates as well as its human counterpart was so far limited to decisions reported by button presses. Thus, here we investigated whether the observed human beta band modulation is specific to the response modality...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28252375/policy-at-play-the-implementation-of-healthy-eating-and-active-living-guidelines-in-municipal-child-care-settings
#10
Kelly McKay, Sherry Nigro
BACKGROUND: In 2012, Ottawa Public Health (OPH) partnered with the City of Ottawa Municipal Child Care (MCC) Services to develop Healthy Eating and Active Living (HEAL) Guidelines. SETTING: The Guidelines aim to promote consistent standards of practice in child care settings related to healthy environments and food, physical activity, physical literacy, decreased sedentary behaviours, and positive role modeling by staff. The Guidelines targeted 498 children aged 18 months to 5 years, attending MCC centres...
March 1, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28148296/comparative-effectiveness-of-a-serious-game-and-an-e-module-to-support-patient-safety-knowledge-and-awareness
#11
RANDOMIZED CONTROLLED TRIAL
Mary E W Dankbaar, Olivier Richters, Cor J Kalkman, Gerrie Prins, Olle T J Ten Cate, Jeroen J G van Merrienboer, Stephanie C E Schuit
BACKGROUND: Serious games have the potential to teach complex cognitive skills in an engaging way, at relatively low costs. Their flexibility in use and scalability makes them an attractive learning tool, but more research is needed on the effectiveness of serious games compared to more traditional formats such e-modules. We investigated whether undergraduate medical students developed better knowledge and awareness and were more motivated after learning about patient-safety through a serious game than peers who studied the same topics using an e-module...
February 2, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28034342/an-evaluation-of-experiences-and-views-of-scottish-leadership-training-opportunities-amongst-primary-care-professionals
#12
Ailsa Power, Helen Allbutt, Lucy Munro, Marion MacLeod, Susan Kennedy, Donald Cameron, Ken Scoular, Graham Orr, John Gillies
AIM: To determine experiences of leadership training of six primary care professions in Scotland and consider future development. METHODS: A questionnaire on previous leadership course attendance and future intentions was distributed to community pharmacists, general dental practitioners, general practitioners, practice nurses, practice managers and optometrists. Analysis comprised descriptive statistics for closed questions and management of textual data. RESULTS: Formal leadership training participation was fairly low except for practice managers...
December 30, 2016: Education for Primary Care
https://www.readbyqxmd.com/read/27975195/serious-games-and-blended-learning-effects-on-performance-and-motivation-in-medical-education
#13
Mary Dankbaar
INTRODUCTION: More efficient, flexible training models are needed in medical education. Information technology offers the tools to design and develop effective and more efficient training. The aims of this thesis were: 1) Compare the effectiveness of blended versus classroom training for the acquisition of knowledge; 2) Investigate the effectiveness and critical design features of serious games for performance improvement and motivation. METHODS: Five empirical studies were conducted to answer the research questions and a descriptive study on an evaluation framework to assess serious games was performed...
February 2017: Perspectives on Medical Education
https://www.readbyqxmd.com/read/27919677/an-individual-differences-approach-to-multiple-target-visual-search-errors-how-search-errors-relate-to-different-characteristics-of-attention
#14
Stephen H Adamo, Matthew S Cain, Stephen R Mitroff
A persistent problem in visual search is that searchers are more likely to miss a target if they have already found another in the same display. This phenomenon, the Subsequent Search Miss (SSM) effect, has remained despite being a known issue for decades. Increasingly, evidence supports a resource depletion account of SSM errors-a previously detected target consumes attentional resources leaving fewer resources available for the processing of a second target. However, "attention" is broadly defined and is composed of many different characteristics, leaving considerable uncertainty about how attention affects second-target detection...
December 17, 2016: Vision Research
https://www.readbyqxmd.com/read/27909379/-it-is-an-eye-opener-that-there-is-a-relationship-between-rehabilitation-and-hiv-perspectives-of-physiotherapists-and-occupational-therapists-in-kenya-and-zambia-on-the-role-of-rehabilitation-with-adults-and-children-living-with-hiv
#15
Stephanie Nixon, Cathy Cameron, Margaret Mweshi, Esther Munalula Nkandu, Carlius Okidi, Stephen Tattle, Tammy Yates
Purpose: To present the perspectives of rehabilitation providers-physiotherapists and occupational therapists-in Kenya and Zambia on the role of rehabilitation in the care of adults and children living with HIV. Methods: This qualitative, interpretivist study was part of a broader project to adapt a Canadian e-module on HIV-related disability for rehabilitation providers in Sub-Saharan Africa (SSA). Focus groups, demographic questionnaires, and knowledge-attitude-belief surveys were conducted with rehabilitation providers in Kenya and Zambia...
2016: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/27887620/anatomy-meets-dentistry-linking-anatomy-and-clinical-practice-in-the-preclinical-dental-curriculum
#16
RANDOMIZED CONTROLLED TRIAL
Nicole Rafai, Martin Lemos, Lieven Nils Kennes, Ayichah Hawari, Susanne Gerhardt-Szép, Irmgard Classen-Linke
BACKGROUND: Establishing a strong link early on between preclinical coursework and the clinical context is necessary for students to be able to recognize the practical relevance of the curriculum during their preclinical anatomical courses and to transfer knowledge more easily. Our objective was to enhance the clinical relevance of a preclinical anatomy course for second-year medical students of dentistry by implementing an interdisciplinary skills training course on "Palpation of the Head and Neck Muscles" and to measure the learning outcomes...
November 25, 2016: BMC Medical Education
https://www.readbyqxmd.com/read/27550846/orf-virus-interleukin-10-and-vascular-endothelial-growth-factor-e-modulate-gene-expression-in-cultured-equine-dermal-fibroblasts
#17
Lyn M Wise, Christa J Bodaan, Andrew A Mercer, Christopher B Riley, Christine L Theoret
BACKGROUND: Wounds in horses often exhibit sustained inflammation and inefficient vascularization, leading to excessive fibrosis and clinical complications such as "proud flesh". Orf virus-derived proteins, vascular endothelial growth factor (VEGF)-E and interleukin (ovIL)-10, enhance angiogenesis and control inflammation and fibrosis in skin wounds of laboratory animals. HYPOTHESIS/OBJECTIVES: The study aimed to determine if equine dermal cells respond to VEGF-E and ovIL-10...
October 2016: Veterinary Dermatology
https://www.readbyqxmd.com/read/27458137/vitamin-d-enhances-the-efficacy-of-irinotecan-through-mir-627-mediated-inhibition-of-intratumoral-drug-metabolism
#18
Meiyan Sun, Qunshu Zhang, Xiaoyu Yang, Steven Y Qian, Bin Guo
Cytochrome P450 enzyme CYP3A4 is an important drug-metabolizing enzyme, and high levels of tumoral expression of CYP3A4 are linked to drug resistance. We investigated the function of vitamin D-regulated miR-627 in intratumoral CYP3A4 suppression and its role in enhancing the efficacy of chemotherapy. We found that miR-627 targets CYP3A4 and suppresses CYP3A4 expression in colon cancer cell lines. Furthermore, calcitriol (the active form of vitamin D) suppressed CYP3A4 expression by activating miR-627. As a result, calcitriol inhibited CYP3A4-mediated metabolism of irinotecan (a topoisomerase I inhibitor) in cancer cells...
September 2016: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/27100104/functional-assessment-of-synoptic-pathology-reporting-for-ovarian-cancer
#19
Janina Słodkowska, Szczepan Cierniak, Janusz Patera, Jarosław Kopik, Włodzimierz Baranowski, Tomasz Markiewicz, Piotr Murawski, Irmina Buda, Wojciech Kozłowski
BACKGROUND: Ovarian cancer has one of the highest death/incidence rates and is commonly diagnosed at an advanced stage. In the recent WHO classification, new histotypes were classified which respond differently to chemotherapy. The e-standardized synoptic cancer pathology reports offer the clinicians essential and reliable information. The aim of our project was to develop an e-template for the standardized synoptic pathology reporting of ovarian carcinoma [based on the checklist of the College of American Pathologists (CAP) and the recent WHO/FIGO classification] to introduce a uniform and improved quality of cancer pathology reports...
2016: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/27049072/is-vitamin-e-an-anti-allergic-compound
#20
A L Caraffa, G Varvara, E Spinas, S K Kritas, G Lessiani, G Ronconi, A Saggini, P Antinolfi, I Frydas, M C De Tommaso Morrison, P Conti
Vitamin E is found in eight forms in nature which include four tocopherols (alpha, beta, gamma and delta) and four tocotrianols (alpha, beta, gamma and delta). The classic effect of vitamin E is to reduce and prevent oxygen damage to the tissue and is useful for the treatment of pain, inflammation and allergic reactions. In addition to antioxidant activity, vitamin E also has a number of different and related functions. It protects against cancer, improves immune response, lowers the incidence of infectious diseases, cardiovascular diseases and is protective in allergy and asthma risk, and other disorders...
January 2016: Journal of Biological Regulators and Homeostatic Agents
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