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https://www.readbyqxmd.com/read/29454265/supplementation-of-lycopene-attenuates-lipopolysaccharide-induced-amyloidogenesis-and-cognitive-impairments-via-mediating-neuroinflammation-and-oxidative-stress
#1
Jia Wang, Lixia Li, Zhuo Wang, Yifan Cui, Xintong Tan, Tian Yuan, Qian Liu, Zhigang Liu, Xuebo Liu
Neuroinflammation is documented to be the major culprit of Alzheimer's disease. Lycopene (LYC), a fat soluble carotenoid, exhibits neuroprotective function in several neurodegenerative disorders. However, the effects of LYC to countering systemic inflammation-induced amyloidogenesis and memory deficiency remain to be elucidated. In current study, 3-month-old male C57BL/6J mice were treated with 0.03% LYC (w/w, mixed into normal chow) for 5 weeks. The mice were then treated by intraperitoneal injection of LPS (0...
February 2, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29454139/implantation-of-the-subcutaneous-implantable-cardioverter-defibrillator-with-truncal-plane-blocks
#2
Marc A Miller, Himani V Bhatt, Menachem Weiner, Tom F Brouwer, Alexander J Mittnacht, Ali Shariat, Christina Jeng, Caroline Eden, Hung-Mo Lin, Benjamin Salter, Srinivas R Dukkipati, Vivek Y Reddy
No abstract text is available yet for this article.
February 14, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29454134/back-pain-improves-significantly-following-discectomy-for-lumbar-disc-herniation
#3
R Kirk Owens, Leah Y Carreon, Erica F Bisson, Mohamad Bydon, Eric A Potts, Steven D Glassman
BACKGROUND CONTEXT: Although lumbar disc herniation (LDH) classically presents with lower extremity radiculopathy, there are patients who have substantial associated back pain PURPOSE: To determine if patients with lumbar disc herniation (LDH) with substantial back pain improve with decompression alone. STUDY DESIGN: Longitudinal observational cohort PATIENT SAMPLE: Patients enrolled in the Quality and Outcomes Database (QOD) with LDH and a baseline back pain score ≥ 5 of 10 who underwent 1 or 2-level lumbar discectomy only OUTCOME MEASURES: Back and leg pain scores (0-10), Oswestry Disability Index (ODI), and EuroQoL 5D (EQ-5D)...
February 14, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29454131/self-reported-headaches-in-patients-with-unruptured-intracranial-aneurysms-treated-with-the-pipeline-embolization-device
#4
Anna M Schneider, Justin M Moore, Nimer Adeeb, Raghav Gupta, Christoph J Griessenauer, Peter A Winkler, Sarah Sieber, Abdulrahman Y Alturki, Christopher S Ogilvy, Ajith J Thomas
INTRODUCTION: The objective of this study was to analyze patients' perceptions of their headaches both prior to and following Pipeline flow diversion treatment of their unruptured intracranial aneurysms, with the goal of identifying prognostic factors associated with headache patterns to improve predictions of overall outcomes. MATERIALS AND METHODS: We retrospectively identified 133 patients treated with the PED between January 1 st 2014 and December 31 st 2016 at an academic institution in the United States...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29454115/traumatic-spinal-injury-global-epidemiology-and-worldwide-volume
#5
Ramesh Kumar, Jaims Lim, Rania A Mekary, Abbas Rattani, Michael C Dewan, Salman Y Sharif, Enrique Osorio-Fonseca, Kee B Park
BACKGROUND: Traumatic spinal injury (TSI) results from injury to bony, ligamentous and/or neurological structures of the spinal column and can cause significant morbidity and mortality. The global burden of TSI is poorly understood, so we performed a systematic review and meta-analysis to estimate the global volume of TSI. METHODS: We performed a systematic review through PubMed, Embase and Cochrane Databases on TSI studies published from 2000 to 2016. Collected data were used to perform a meta-analysis to estimate the annual incidence of TSI across World Health Organization (WHO) regions and World Bank income groups using random effect models...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29454054/genomic-perspectives-of-spider-silk-genes-through-target-capture-sequencing-conservation-of-stabilization-mechanisms-and-homology-based-structural-models-of-spidroin-terminal-regions
#6
Matthew A Collin, Thomas H Clarke, Nadia A Ayoub, Cheryl Y Hayashi
A powerful system for studying protein aggregation, particularly rapid self-assembly, is spider silk. Spider silks are proteinaceous and silk proteins are synthesized and stored within silk glands as liquid dope. As needed, liquid dope is near-instantaneously transformed into solid fibers or viscous adhesives. The dominant constituents of silks are spidroins (spider fibroins) and their terminal domains are vital for the tight control of silk self-assembly. To better understand spidroin termini, we used target capture and deep sequencing to identify spidroin gene sequences from six species representing the araneoid families of Araneidae, Nephilidae, and Theridiidae...
February 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29454011/comparative-study-on-some-oxidative-stress-parameters-in-blood-of-vitiligo-patients-before-and-after-combined-therapy
#7
A Zheleva, G Nikolova, Y Karamalakova, E Hristakieva, R Lavcheva, V Gadjeva
Currently accepted that oxidative stress is a triggering event in the melanocytic destruction and is probably involved in the etiopathogenesis of vitiligo disease. Despite numerous investigations, contradictory results were reported about the levels of oxidative stress biomarkers measured in the skin and blood of vitiligo patients. By Electron Paramagnetic Resonance spectroscopy (EPR) and spectrophotometry, we have investigated and compared some oxidative stress biomarkers in the blood of vitiligo patients' before and after UVB Narrow Band 311 nm phototherapy combined with the antioxidant nutritional supplement containing - Vitamin C, Vitamin B1, L -Cysteine, Lipoic Acid, and polyunsaturated fatty acids...
February 14, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29453834/demystifying-evidence-based-policy-analysis-by-revealing-hidden-value-laden-constraints
#8
Adam M Finkel
Consider any choice that affects some social policy. A decision that considers evidence will, at its heart, contain some kind of explicit or implicit "because" statement: "We are doing X because the evidence says Y." But can evidence ever truly speak for itself, in the sense of being reducible to objective utterances that are either correct or in need of correction? Before answering, consider what you'd prefer. Would you rather receive evidence that was free of any value judgments imposed by human actors, that was laden with value judgments that you agree with, or laden with value judgments that you disagree with? The central assertion of this essay is that, throughout policy analysis but especially in assessments of the costs and benefits of regulating versus encouraging new technologies (cost-benefit analysis, or CBA), the first possibility above is a mirage, and the second and third are self-contradictory...
January 2018: Hastings Center Report
https://www.readbyqxmd.com/read/29453830/eosinophilic-polymorphic-and-pruritic-eruption-associated-with-radiotherapy-in-a-patient-with-primary-nodal-merkel-cell-carcinoma
#9
Wedad Abdelrahman, Lin Shum, Damian McManus, Maureen Y Walsh, Olivia Dolan
No abstract text is available yet for this article.
February 16, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29453734/post-operative-imaging-assessment-of-non-functioning-pituitary-adenomas
#10
REVIEW
Kunal S Patel, Sanjay Dhawan, Renzhi Wang, Bob S Carter, James Y Chen, Clark C Chen
BACKGROUND: Non-functioning pituitary adenomas (NFAs) are the most common pituitary tumors. There is significant variability in clinical practice in terms of post-operative imaging evaluation. The objective of this manuscript is to provide an exhaustive review of published articles pertaining to the post-operative imaging evaluation of NFAs. METHODS: The MEDLINE database was queried for studies investigating imaging for the post-operative evaluation of pituitary adenomas...
February 16, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29453687/impact-of-boosted-antiretroviral-therapy-on-the-pharmacokinetics-and-efficacy-of-clopidogrel-and-prasugrel-active-metabolites
#11
Niloufar Marsousi, Youssef Daali, Pierre Fontana, Jean-Luc Reny, Virginie Ancrenaz-Sirot, Alexandra Calmy, Serge Rudaz, Jules Alexandre Desmeules, Caroline Flora Samer
BACKGROUND AND OBJECTIVES: Prasugrel and clopidogrel are inhibitors of the ADP-P 2 Y 12 platelet receptor used in acute coronary syndrome patients. They require bioactivation via isoenzymes such as cytochrome P450 (CYP) 3A4, CYP2C19 and CYP2B6. Ritonavir and cobicistat are potent CYP3A inhibitors, prescribed as pharmacokinetic (PK) enhancers in the treatment of human immunodeficiency virus (HIV) infection. METHODS: In this study, the impact of boosted antiretroviral therapies (ARTs) on the PK of clopidogrel and prasugrel active metabolites (AMs), and on the efficacy of prasugrel and clopidogrel, were evaluated in a randomized crossover clinical trial...
February 16, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29453682/persistent-pulmonary-hypertension-and-histologic-chorioamnionitis-in-preterm-infants-controlled-study
#12
N Katz, Y Bar-Or, A Raucher-Sterrnfeld, A Tamir, D Kohelet
Persistent pulmonary hypertension (PPHN) of the newborn is one of the most challenging acute disorders of postnatal transition with substantial morbidity and mortality. The aim of the study was to find if there is an association between persistent pulmonary hypertension and histologic chorioamnionitis in preterm infants. 27 preterm infants with echocardiographic evidence of PPHN within the first 3 days of life were eligible for the study. A matched control group of 27 patients was chosen according to gestational age, date of birth, and gender...
February 16, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29453654/uterine-electrical-activity-oxytocin-and-labor-translating-electrical-into-mechanical
#13
Anat Lavie, S Shinar, L Hiersch, E Ashwal, Y Yogev, A Aviram
PURPOSE: Uterine activity plays a crucial role in labor, especially when utero-tonic materials are administered. We aimed to determine the electrical responsiveness of the uterine musculature to labor augmentation with oxytocin using electrical uterine myography (EUM) technology, and to assess whether the kinetics of the EUM device may serve as a predictor for successful vaginal delivery. METHODS: EUM prospectively measured electrical uterine activity in women with singleton gestations at term (≥ 37 + 0 weeks) undergoing labor augmentation by oxytocin administration...
February 16, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29453583/reconstruction-for-chronic-achilles-tendinopathy-comparison-of-flexor-hallucis-longus-fhl-transfer-versus-v-y-advancement
#14
Jackson R Staggers, Kenneth Smith, Cesar de C Netto, Sameer Naranje, Krishna Prasad, Ashish Shah
BACKGROUND: Several operative techniques exist for Achilles tendinopathy. The purpose of our study was to compare the clinical and functional outcomes of flexor hallucis longus (FHL) transfer and V-Y advancement for the treatment of chronic insertional Achilles tendinopathy. METHODS: Retrospective chart review from 2010 to 2016 of patients that underwent FHL transfer or V-Y advancement for chronic insertional Achilles tendinopathy. Outcome measures were compared for these two procedures...
February 16, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29453582/the-clinical-phenotype-of-patients-positive-for-antibodies-to-myositis-and-myositis-related-disorders
#15
S G Gofrit, H Yonath, M Lidar, Y Shoenfeld, S Kivity
Inflammatory myopathies are a clinically diverse group of diseases, in which the detection of particular autoantibodies may facilitate diagnosis, treatment, and prognosis. The aim of this report is to summarize our experience with specific autoantibody testing in patients with inflammatory myopathies. Data were collected over the last decade in the Autoimmune Center of the Sheba Medical Center, a tertiary referral hospital. Data regarding patients' positive for autoantibodies against Jo-1, PL-7, PL-12, SRP, Mi-2, Ku, and PM-Scl antigens were retrospectively collected...
February 16, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29453464/dietitian-led-lifestyle-modification-programme-for-obese-chinese-adolescents-with-non-alcoholic-fatty-liver-disease-a-randomized-controlled-study
#16
D F Y Chan, H K So, S C N Hui, R S M Chan, A M Li, M M Sea, W C W Chu, M Chan, J Woo, E A S Nelson
BACKGROUND: The prevalence of non-alcoholic fatty liver disease (NAFLD) in children is increasing. This study evaluated the efficacy of a dietitian-led lifestyle modification programme (D-LMP) to reduce NAFLD in obese adolescents. METHODS: Subjects with intra-hepatic triglyceride content (IHTC) equal to or greater than 5% diagnosed by proton-magnetic resonance spectroscopy ( 1 H-MRS) were enroled and randomly assigned to either the D-LMP intervention or conventional paediatrician-led consultation (P-CON) group...
January 30, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29453461/roux-en-y-gastric-bypass-and-sleeve-gastrectomy-induces-specific-shifts-of-the-gut-microbiota-without-altering-the-metabolism-of-bile-acids-in-the-intestinal-lumen
#17
Henri Duboc, Caroline Chong Nguyen, Jean-Baptiste Cavin, Lara Ribeiro-Parenti, Anne-Charlotte Jarry, Dominique Rainteau, Lydie Humbert, Benoit Coffin, Maude Le Gall, André Bado, Harry Sokol
Some shifts in the gut microbiota composition and its metabolic fingerprints have been associated to Sleeve gastrectomy (SG) and Roux-en-Y Gastric Bypass (RYGB). So far, plasma bile acids have been associated with post-operative glucose improvement and weight loss, but nothing is known about their metabolism in the gut lumen. As bile acids are physiologically transformed by the microbiota into various species, the aim of this work was to study how SG and RYGB-associated dysbiosis impact the bioconversion of bile acids in the intestinal lumen...
January 30, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29453460/development-and-initial-characterization-of-a-novel-ghrelin-receptor-crispr-cas9-knockout-wistar-rat-model
#18
L J Zallar, B J Tunstall, C T Richie, Y J Zhang, Z B You, E L Gardner, M Heilig, J Pickel, G F Koob, L F Vendruscolo, B K Harvey, L Leggio
BACKGROUND/OBJECTIVES: Ghrelin, a stomach-derived hormone implicated in numerous behaviors including feeding, reward, stress, and addictive behaviors, acts by binding to the growth hormone secretagogue receptor (GHSR). Here, we present the development, verification, and initial characterization of a novel GHSR knockout (KO) Wistar rat model created with CRISPR genome editing. METHODS: Using CRISPR/Cas9, we developed a GHSR KO in a Wistar background. Loss of GHSR mRNA expression was histologically verified using RNAscope in wild-type (WT; n = 2) and KO (n = 2) rats...
January 30, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29453428/igf-i-and-igfbp-3-concentrations-at-2-years-associations-with-anthropometry-and-milk-consumption-in-an-indian-cohort
#19
Andrea S Wiley, Suyog M Joshi, Himangi G Lubree, Dattatray S Bhat, Neelam S Memane, Deepa A Raut, Chittaranjan S Yajnik
BACKGROUND/OBJECTIVES: To ascertain associations between plasma insulin-like growth factor I (IGF-I), insulin-like growth factor-binding protein 3 (IGFBP-3) and their molar ratio at 2 y with neonatal size, infant growth, body composition at 2 y, and feeding practices in an Indian cohort. SUBJECTS/METHODS: A cohort of 209 newborns, with 122 followed at 2 y. Anthropometry was conducted at birth and 2 y. IGF-I and IGFBP-3 concentrations were measured in cord blood and at 2 y...
February 16, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29453407/neovasculature-can-be-induced-by-patching-an-arterial-graft-into-a-vein-a-novel-in-vivo-model-of-spontaneous-arteriovenous-fistula-formation
#20
Yukinobu Ito, Makoto Yoshida, Daichi Maeda, Masato Takahashi, Hiroshi Nanjo, Hirotake Masuda, Akiteru Goto
Arteriovenous malformations consist of tangles of arteries and veins that are often connected by a fistula. The causes and mechanisms of these clinical entities are not fully understood. We discovered that suturing an arterial patch into the common jugular vein of rabbits led to spontaneous neovascularization, the formation of an arteriovenous fistula and the development of an arteriovenous shunt. An arterial patch excised from the common carotid artery was sutured into the common jugular vein. Within a month, a dense nidus-like neovasculature formed around the patch...
February 16, 2018: Scientific Reports
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