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PTHrP

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https://www.readbyqxmd.com/read/29755405/dual-paraneoplastic-endocrine-syndromes-heralding-onset-of-extrapulmonary-small-cell-carcinoma-a-case-report-and-narrative-review
#1
Jill B Feffer, Natalia M Branis, Jeanine B Albu
Objective: Extrapulmonary small cell carcinoma (EPSCC) is rare and frequent metastases at presentation can complicate efforts to identify a site of origin. In particular, SCC comprises <1% of prostate cancers and has been implicated in castration resistance. Methods: Clinical, laboratory, imaging, and pathology data are presented. Results: A 56-year-old man with locally advanced prostate adenocarcinoma on androgen deprivation therapy presented with a clogged nephrostomy tube...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29702220/dicam-promotes-proliferation-and-maturation-of-chondrocyte-through-indian-hedgehog-signaling-in-primary-cilia
#2
Seungwoo Han, Hye-Ri Park, Eun-Ju Lee, Ji-Ae Jang, Min-Su Han, Gun-Woo Kim, Jae-Hwan Jeong, Je-Yong Choi, Beier Frank, Youn-Kwan Jung
OBJECTIVES: Primary cilium is required for mechano-biological signal transduction in chondrocytes, and its interaction with extracellular matrix is critical for cartilage homeostasis. However, the role of cilia-associated proteins that affect the function of cilia remains to be elucidated. Here, we show that Dicam has a novel function as a modulator of primary cilia-mediated Indian hedgehog (Ihh) signaling in chondrocytes. METHODS: Cartilage-specific Dicam transgenic mouse was constructed and the phenotype of growth plates at embryonic day 15...
April 24, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29694631/humoral-hypercalcemia-of-pregnancy-treated-with-bisphosphonates
#3
Ronit Koren, Ortal Neeman, Shlomit Koren, Carlos A Benbassat
Hypercalcemia can be hazardous during pregnancy, most cases being due to primary hyperparathyroidism. We report a case of hypercalcemia with suppressed PTH levels necessitating treatment with bisphosphonates during pregnancy. A 38-year-old woman at the 26th week gestation was admitted because of symptomatic hypercalcemia. She did not take any medication that could influence her calcium levels. Physical examination was unremarkable. Laboratory tests on admission were: calcium 12.7 mg/dL (8.5-10.5 mg/dL), phosphorus 1...
February 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29691795/improved-protocol-for-chondrogenic-differentiation-of-bone-marrow-derived-mesenchymal-stem-cells-effect-of-pthrp-and-fgf-2-on-tgf%C3%AE-1-bmp2-induced-chondrocytes-hypertrophy
#4
Davood Nasrabadi, Siamak Rezaeiani, Mohamadreza Baghaban Eslaminejad, Aliakbar Shabani
Growth factors have a pivotal role in chondrogenic differentiation of stem cells. The differential effects of known growth factors involved in the maintenance and homeostasis of cartilage tissue have been previously studied in vitro. However, there are few reported researches about the interactional effects of growth factors on chondrogenic differentiation of stem cells. The aim of this study is to examine the combined effects of four key growth factors on chondrogenic differentiation of mesenchymal stem cells (MSCs)...
April 24, 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29689559/molecular-regulation-of-bone-metastasis-pathogenesis
#5
Meng-Yu Wu, Chia-Jung Li, Giou-Teng Yiang, Yeung-Leung Cheng, Andy Po-Yi Tsai, Yueh-Tseng Hou, Yu-Chieh Ho, Ming-Feng Hou, Pei-Yi Chu
Distant metastases are the major cause of mortality in cancer patients. Bone metastases may cause bone fractures, local pain, hypercalcemia, bone marrow aplasia, and spinal cord compression. Therefore, the management of bone metastases is important in cancer treatment. Normal bone remodeling is regulated by osteoprotegerin ligand (OPGL), receptor activator of NF-κB ligand (RANKL), parathyroid hormone-related protein (PTHrP), and other cytokines. In the tumor microenvironment, tumor cells induce a vicious cycle that promotes osteoblastic and osteolytic lesions...
April 18, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29670736/expression-of-parathyroid-hormone-related-protein-pthrp-in-ameloblastomas
#6
Rafael Zeballos, Ronell Bologna-Molina, Vanesa Pereira-Prado, Mariana Villarroel-Dorrego
Background: Presence of parathyroid hormone related protein (PTHrP) might suggest that ameloblastomas recapitulate features of the enamel epithelium and induce bone resorption, which would facilitate their growth and local invasion. The aim of this study was to determine the expression of PTHrP in ameloblastomas. Material and Methods: An observational research study was designed including 39 cases of histologically diagnosed ameloblastomas (39 out of 42 patients gave consent for the use of their medical records and all data required for this study)...
February 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29667006/establishment-and-characterization-of-a-c57bl-6-mouse-model-of-bone-metastasis-of-breast-cancer
#7
Toru Hiraga, Tadashi Ninomiya
Bone is one of the most common sites of metastasis in patients with advanced breast cancer; however, the mechanisms of bone metastasis remain to be fully elucidated. Animal models are essential research tools for investigating the mechanisms of diseases and drug actions. To date, there have only been a few reports in which C57BL/6 mice were used for the study of bone metastases of breast cancer. In the current study, we found that intracardiac inoculation of C57BL/6 mouse-derived parental E0771 breast cancer cells (E0771/Pa) frequently lead to bone metastases in C57BL/6 mice within 2 weeks...
April 17, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29659051/psa-alpha-2-macroglobulin-complex-is-enzymatically-active-in-the-serum-of-patients-with-advanced-prostate-cancer-and-can-degrade-circulating-peptide-hormones
#8
Maya B Kostova, William Nathaniel Brennen, David Lopez, Lizamma Anthony, Hao Wang, Elizabeth Platz, Samuel R Denmeade
BACKGROUND: Prostate cancer cells produce high levels of the serine protease Prostate-Specific Antigen (PSA). PSA is enzymatically active in the tumor microenvironment but is presumed to be enzymatically inactive in the blood due to complex formation with serum protease inhibitors α-1-antichymotrypsin and α-2-macroglobulin (A2M). PSA-A2M complexes cannot be measured by standard ELISA assays and are also rapidly cleared from the circulation. Thus the exact magnitude of PSA production by prostate cancer cells is not easily measured...
April 16, 2018: Prostate
https://www.readbyqxmd.com/read/29627891/anabolic-agents-what-is-beyond-osteoporosis
#9
REVIEW
Y Liu, A E Levack, E Marty, O Or, B P Samuels, M Redko, J M Lane
Osteoporosis is a common skeletal disorder characterized by low bone mass, which leads to reduced bone strength and an increased risk of fractures. Anabolic agents have been shown to improve bone mass and decrease fracture risk in osteoporosis patients by directly stimulating osteoblasts to produce new bone. Currently, two anabolic agents are available in the USA: recombinantly produced teriparatide (TPTD), which is the fully active (1-34) amino active sequence of human parathyroid hormone (PTH), and abaloparatide (APTD), a synthetic analog of parathyroid hormone-related peptide (PTHrP)...
April 7, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29617866/serotonin-induces-parathyroid-hormone-related-protein-in-goat-mammary-gland
#10
W J Zang, H Li, Z F Zhang, R QuZhen, Y Z CuoMu, D K Zhang, J Luo, J J Loor, H L Zheng
During lactation, large amounts of calcium are exported from the mammary gland into milk to ensure skeletal growth of the offspring. Recent studies revealed that serotonin (5-HT) is essential to stimulate skeletal calcium resorption for milk synthesis. Our objective was to explore the correlation between circulating 5-HT and serum calcium and parathyroid hormone-related protein (PTHrP) concentrations around parturition in dairy goats. We also investigated the effect of 5-HT on PTHrP expression in cultured primary goat mammary epithelial cells (GMEC)...
April 3, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29603329/calcium-calmodulin-dependent-protein-kinaseii-in-occlusion-induced-degenerative-cartilage-of-rat-mandibular-condyle
#11
Qian Liu, Hong-Xu Yang, Xiang-Hong Wan, Mian Zhang, Jing Zhang, Lei Lu, Mianjiao Xie, Hao-Tian Ren, Shi-Bin Yu, Xiao-Dong Liu, Meiqing Wang
Activated calcium/calmodulin dependent protein kinaseII (CaMKII) is important to promote chondrocytes from proliferative to pre-hypertrophic state, which probably plays a role in osteoarthritis (OA), a wide-spread degeneration disease with enhanced aberrant chondrocyte differentiation. Our aim is to detect the role of CaMKII, and its relationship with Indian hedgehog (Ihh)-Parathyroid-related peptide (PTHrP) feedback loop in the temporomandibular joints (TMJs) OA. KN93, the competitive inhibitor of CaMKII, was added to the culture medium in vitro, and was locally injected to rats TMJs (n=54, female) every other day for 4 weeks from the beginning of the 5th and 9th week after installing of unilateral anterior crossbite (UAC), termed as 4wk+4wk and 8wk+4wk, accordingly...
March 30, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29603039/could-use-of-selective-serotonin-reuptake-inhibitors-during-lactation-cause-persistent-effects-on-maternal-bone
#12
REVIEW
Samantha R Weaver, Laura L Hernandez
The lactating mammary gland elegantly coordinates maternal homeostasis to provide calcium for milk. During lactation, the monoamine serotonin regulates the synthesis and release of various mammary gland-derived factors, such as parathyroid hormone-related protein (PTHrP), to stimulate bone resorption. Recent evidence suggests that bone mineral lost during prolonged lactation is not fully recovered following weaning, possibly putting women at increased risk of fracture or osteoporosis. Selective Serotonin Reuptake Inhibitor (SSRI) antidepressants have also been associated with reduced bone mineral density and increased fracture risk...
March 30, 2018: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/29589391/effects-of-serum-albumin-calcium-levels-cancer-stage-and-performance-status-on-weight-loss-in-parathyroid-hormone-related-peptide-positive-or-negative-patients-with-cancer
#13
Ji Yeon Lee, Namki Hong, Hye Ryun Kim, Byung Wan Lee, Eun Seok Kang, Bong Soo Cha, Yong Ho Lee
BACKGROUND: A recent animal study showed that parathyroid hormone-related peptide (PTHrP) is associated with cancer cachexia by promoting adipose tissue browning, and we previously demonstrated that PTHrP predicts weight loss (WL) in patients with cancer. In this study, we investigated whether prediction of WL by PTHrP is influenced by clinical factors such as serum albumin, corrected calcium levels, cancer stage, and performance status (PS). METHODS: A cohort of 219 patients with cancer whose PTHrP level was measured was enrolled and followed for body weight (BW) changes...
March 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29548309/acantholytic-squamous-cell-carcinoma-of-the-lung-with-marked-lymphogenous-metastases-and-high-titers-of-myeloperoxidase-antineutrophil-cytoplasmic-antibodies-a-case-report
#14
Kenji Yorita, Kazuya Tsuji, Yoko Takano, Naoto Kuroda, Kei Sakamoto, Kaoru Arii, Yukio Yoshimoto, Kimiko Nakatani, Satoshi Ito
BACKGROUND: Acantholytic squamous cell carcinoma (ASQCC), histologically characterized by intercellular bridge loosening, is recognized as a rare variant of squamous cell carcinoma (SQCC). ASQCC may demonstrate a worse prognosis than conventional SQCC. Pulmonary ASQCC is particularly rare; its biological behavior and prognostic data have not been reported. CASE PRESENTATION: We report the clinical and autopsy findings of a 71-year-old Japanese man with pulmonary ASQCC...
March 16, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29512770/inhibition-effects-of-total-flavonoids-from-sculellaria-barbata-d-don-on-human-breast-carcinoma-bone-metastasis-via-downregulating-pthrp-pathway
#15
Xiao Zheng, Wen Kang, Huihui Liu, Shanyu Guo
It is abundantly clear that tumor-derived parathyroid hormone-related protein (PTHrP), receptor activator of nuclear factor-κB ligand (RANKL) and osteoprotegerin (OPG) are central contributors in promoting osteolytic process of breast carcinoma bone metastasis. Forcusing on this molecular basis, the study was undertaken to explore the inhibition effects of total flavonoids from Scutellaria barbata D. Don (TF-SB) on human breast carcinoma bone metastasis. MDA-MB-231 cells and nude mouse models of breast cancer bone metastasis were given TF-SB in different concentrations...
June 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29504802/review-of-polymorphism-of-the-calcium-sensing-receptor-gene-and-breast-cancer-risk
#16
REVIEW
Larysse Maira Campos-Verdes, Danylo Rafhael Costa-Silva, João Paulo da Silva-Sampaio, Maria da Conceição Barros-Oliveira, Carla Solange Escórcio-Dourado, Luana Mota Martins, Fabiane Araújo Sampaio, Camila Revoredo, Francisco Adelton Alves-Ribeiro, Benedito Borges da Silva
Polymorphism of the calcium-sensing receptor gene (CaSR or CaR) has been associated with an increased risk for breast cancer. This receptor plays an important role in calcium homeostasis, and has also been detected in several tissues that are unrelated to calcium metabolism, such as the skin, brain, and breast. The calcium-sensing receptor on cellular level, it regulates cell differentiation, proliferation, cell death, and gene expression. In breast cancer cells, CaSR seems to stimulate secretion of the parathyroid hormone-related protein (PTHrP), which stimulates cellular proliferation...
February 7, 2018: Cancer Investigation
https://www.readbyqxmd.com/read/29497363/parathyroid-hormone-related-peptide-elicits-peripheral-trpv1-dependent-mechanical-hypersensitivity
#17
Andrew J Shepherd, Aaron D Mickle, Suraj Kadunganattil, Hongzhen Hu, Durga P Mohapatra
Bone metastasis in breast, prostate and lung cancers often leads to chronic pain, which is poorly managed by existing analgesics. The neurobiological mechanisms that underlie chronic pain associated with bone-metastasized cancers are not well understood, but sensitization of peripheral nociceptors by tumor microenvironment factors has been demonstrated to be important. Parathyroid hormone-related peptide (PTHrP) is highly expressed in bone-metastasized breast and prostate cancers, and is critical to growth and proliferation of these tumors in the bone tumor microenvironment...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29394342/pth1r-signalling-regulates-the-mechanotransduction-process-of-cementoblasts-under-cyclic-tensile-stress
#18
Shengnan Li, Fan Li, Shujuan Zou, Li Zhang, Yuxing Bai
Objective: To investigate the regulatory role of type I parathyroid hormone receptor (PTH1R) signalling in the mechanotransduction process of cementoblasts under cyclic tensile stress (CTS). Materials and methods: Immortalized cementoblast cell line OCCM-30 were employed and subjected to cyclic tensile strain applied by a four-point bending system. The expression of PTHrP and PTH1R, as well as cementoblastic transcription factor Runx-2, Osterix, and extracellular matrix protein COL-1 and OPN were assessed by quantitative real-time polymerase chain reaction and western blot analysis...
January 31, 2018: European Journal of Orthodontics
https://www.readbyqxmd.com/read/29390136/mir-374-5p-mir-379-5p-and-mir-503-5p-regulate-proliferation-and-hypertrophic-differentiation-of-growth-plate-chondrocytes-in-male-rats
#19
Youn Hee Jee, Jinhee Wang, Shanna Yue, Melissa Jennings, Samuel J H Clokie, Ola Nilsson, Julian Lui, Jeffrey Baron
Growth plate chondrocytes undergo sequential differentiation to form the resting (RZ), proliferative (PZ), and hypertrophic zones (HZ). The important role of microRNAs (miRNAs) in the growth plate was previously revealed by cartilage-specific ablation of Dicer, an enzyme essential for biogenesis of many miRNAs. To identify specific miRNAs that regulate differentiation of PZ chondrocytes to HZ chondrocytes, we microdissected individual growth plate zones from juvenile rats and performed miRNA profiling using a solution hybridization method and also miRNA-seq...
January 30, 2018: Endocrinology
https://www.readbyqxmd.com/read/29379848/bone-adaptation-in-response-to-treadmill-exercise-in-young-and-adult-mice
#20
Joseph D Gardinier, Niloufar Rostami, Lauren Juliano, Chunbin Zhang
Exercise is a key determinate of fracture risk and provides a clinical means to promote bone formation. However, the efficacy of exercise to increase bone mass declines with age. The purpose of this study was to identify age-related differences in the anabolic response to exercise at the cellular and tissue level. To this end, young (8-weeks of age) and adult (36-weeks of age) male mice were subjected to a moderate exercise regimen of running on a treadmill. As a result, exercise had a significant effect on PTHrP and SOST gene expression during the first week that was dependent upon age...
June 2018: Bone Reports
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