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Naproxen interstitial nephritis

Fareha A Nawaz, Christopher P Larsen, Megan L Troxell
Membranous nephropathy presents clinically as nephrotic syndrome, with subepithelial immune complex deposits seen on biopsy. Historically, in about three-quarters of membranous cases, no obvious etiologic agent or condition can be identified. More recently, serum antibodies to the phospholipase A2 receptor have been discovered in many patients with primary/idiopathic membranous nephropathy. About one-quarter of patients have membranous nephropathy as a manifestation of another systemic disorder, such as autoimmune conditions, infection, malignancy, toxin exposure, or drugs (classically gold or penicillamine)...
November 2013: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Jennifer Lua, Christopher O C Bellamy, Caroline Whitworth, Neeraj Dhaun
No abstract text is available yet for this article.
October 2011: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
M Kaye, R F Gagnon
No abstract text is available yet for this article.
April 2008: Kidney International
J Granese, K Brightbill, P Osborne, C E Cox, L W Gaber
Analgesic nephropathy results from chronic abuse of non-narcotic analgesics, most frequently with the use of phenacetin and mixed analgesic preparations. Renal papillary necrosis and chronic interstitial nephritis with progressive scarring are characteristic of the histopathology of analgesic nephropathy. Typically, papillary necrosis in these patients is bilateral and affects almost all renal papillae. This report describes a case of severe analgesic nephropathy that discriminantly affected a unilateral non-functioning kidney and spared the contralateral normally developed kidney...
August 2007: Clinical Nephrology
Larisa Kovacevic, Jay Bernstein, Rudolph P Valentini, Abubakr Imam, Neena Gupta, Tej K Mattoo
A 17-year-old healthy girl was admitted to our hospital with diffuse abdominal pain and decreased oral intake of about 11 days duration. About a week prior to admission, she had taken naproxen, 250 mg four times a day for 4 days. Physical examination was normal except for diffuse abdominal tenderness on deep palpation. Investigations revealed high serum BUN (42 mg/dl) and creatinine (4.0 mg/dl). Serum electrolytes and complement (C3, C4) levels and urinalysis were normal. Antinuclear-antibody and anti-dsDNA were negative...
August 2003: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
R Becker-Cohen, Y Frishberg
UNLABELLED: Acute interstitial nephritis is uncommon in children and has very rarely been described with naproxen treatment. We report the occurrence of severe acute renal failure in a 10-year-old girl with juvenile rheumatoid arthritis after 1 month of naproxen therapy. Renal biopsy showed severe acute interstitial nephritis. The patient recovered completely after discontinuation of naproxen and administration of methylprednisolone. A review of the literature regarding non-steroidal anti-inflammatory drug-associated acute interstitial nephritis is provided...
May 2001: European Journal of Pediatrics
M W Leach, D W Frank, M R Berardi, E W Evans, R C Johnson, D G Schuessler, E Radwanski, M E Cartwright
Naproxen sodium was administered to cynomolgus monkeys (Macaca fascicularis) by oral gavage at daily doses of 44, 88, or 176 mg/kg for 2 wk (2 monkeys/gender) or of 44 mg/kg for 13 wk (4 monkeys/gender). Body weight loss occurred in at least one monkey in all naproxen sodium-dosed groups in the 2-wk (up to 16% loss) and 13-wk (up to 22% loss) studies. Increases in plasma naproxen concentrations were dose proportional between 44 and 88 mg/kg but were less than dose proportional between 88 and 176 mg/kg. Up to 2-fold increases in creatinine and/or serum urea nitrogen values as well as higher renal weights occurred in monkeys receiving 176 mg/kg for 2 wk or 44 mg/kg for 13 wk...
May 1999: Toxicologic Pathology
M R Quigley, M Richfield, F A Krumlovsky, Y S Kanwar, F A Carone, M P Jarrett
No abstract text is available yet for this article.
August 1982: Arthritis and Rheumatism
W G Wasser, M H Goldstein, F Barba, J Churg
No abstract text is available yet for this article.
March 1982: Mount Sinai Journal of Medicine, New York
W B Reeves, R J Foley, E J Weinman
We categorize the three types of renal dysfunction associated with the use of nonsteroidal anti-inflammatory drugs (NSAID): acute renal failure, acute interstitial nephritis, and hyperkalemia. The paper provides clinical examples of each type, discusses pathophysiology, and describes response to therapy, in addition to outlining the usefulness of labeled leukocyte nuclear studies and kidney biopsy. We conclude that these drugs are relatively common causes of renal dysfunction, particularly in selected subpopulations...
March 1985: Southern Medical Journal
R M Laxer, E D Silverman, J W Balfe, S Poucell, R Baumal
Renal failure occurred in a 14-year-old girl with peripheral arthritis associated with inflammatory bowel disease while she was being treated with naproxen. She had previously received aspirin and tolmetin sodium and had no complications. A renal biopsy showed a severe tubulointerstitial nephritis. Although her renal function improved somewhat with corticosteroid treatment, it worsened when the steroids were discontinued. This case emphasizes that renal failure can develop insidiously in children on nonsteroidal anti-inflammatory drug therapy and that such children must be monitored closely for signs of nephrotoxicity...
December 1987: Pediatrics
P E Ray, D Rigolizzo, D R Wara, C F Piel
The development of acute renal failure and interstitial nephritis due to therapeutic doses of nonsteroidal anti-inflammatory drugs has been documented repeatedly in adult patients but is rare in children. We report the occurrence of this complication in a child. Acute renal failure and hyperkalemia developed in a 2-year-old boy with juvenile rheumatoid arthritis after one month of naproxen sodium therapy. The evidence of renal toxic effects became manifest after an episode of dehydration. A percutaneous renal biopsy specimen revealed interstitial nephritis...
May 1988: American Journal of Diseases of Children
R Maniglia, A B Schwartz, S Moriber-Katz
Non-steroidal anti-inflammatory drugs have a wide range of use in clinical practice because of their analgesic and anti-inflammatory properties. However, their potential nephrotoxicity has been noted. The case histories were studied, retrospectively, in 13 patients who were taking non-steroidal anti-inflammatory drugs as follows: four on fenoprofen (Nalfon), three on naproxen (Naprosyn), two on ibuprofen (Motrin), two on sulindac (Clinoril), one on tolmetin (Tolectin), and one on indomethacin (Indocin) and who exhibited abnormal urinalysis or a deterioration in renal function...
May 1988: Annals of Clinical and Laboratory Science
D H Adams, A J Howie, J Michael, B McConkey, P A Bacon, D Adu
In 3 years seventeen patients presented to one unit with renal failure associated with the use of non-steroidal anti-inflammatory drugs (NSAID). Seven patients presented with acute renal failure, in four due to acute tubular necrosis and in three to acute interstitial nephritis; all recovered when NSAID treatment was stopped. Four patients presented with symptomless renal impairment discovered during routine follow-up in a rheumatology clinic; again all improved on withdrawal of NSAID. The remaining six patients presented with chronic renal failure, a disorder not previously associated with NSAID treatment...
January 11, 1986: Lancet
G H Thoenes, T Sitter, K H Langer, R R Bartlett, R Schleyerbach
Experimental tubulointerstitial nephritis (TIN), induced in Brown Norway rats, is an autoimmune disorder in which afflicted animals display high levels of serum autoantibodies directed against antigens present on the tubular basement membrane (TBM). Serious functional damage, due to lesions of the kidney cortex, is evident 10 days after disease initiation. In an earlier study, we could show that cyclosporin A (CsA), an immunosuppressive drug, effectively prevented the onset of this illness, although it did not inhibit the formation of TBM autoantibodies...
1989: International Journal of Immunopharmacology
J D McCue, J Pepe
No abstract text is available yet for this article.
August 15, 1989: Hospital Practice
B N Ling, E Bourke, W G Campbell, V B Delaney
A 34-year-old female with an 8-month history of systemic lupus erythematosus and intermittent naproxen use presented with acute oliguric renal failure, hypoalbuminemia, 4+ proteinuria, and an active urinary sediment. The clinical picture suggested a rapidly progressive lupus glomerulonephritis. Renal biopsy, however, demonstrated chronic, active interstitial nephritis without evidence of immune deposits by immunofluorescence or electron microscopy. Nonsclerotic glomeruli revealed diffuse foot process fusion without cellular proliferation...
1990: Nephron
J Nortier, M Depierreux, V Bourgeois, J Ducobu, P Dupont
This article reports an unusual case of acute interstitial nephritis associated with nephrotic syndrome which appeared after oral intake of naproxen and amoxicillin and led to end-stage renal failure. In the light of recent literature on this clinical entity, the authors formulate hypotheses accounting for this outcome.
May 1991: Clinical Nephrology
J H Brezin, S M Katz, A B Schwartz, J L Chinitz
No abstract text is available yet for this article.
December 6, 1979: New England Journal of Medicine
K C Cartwright, T L Trotter, M L Cohen
No abstract text is available yet for this article.
February 1979: Arizona Medicine
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