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https://www.readbyqxmd.com/read/29454127/neurosurgery-on-a-pregnant-woman-with-post-mortem-fetal-extrusion-an-unusual-case-from-medieval-italy
#1
REVIEW
Alba Pasini, Vanessa Samantha Manzon, Xabier Gonzalez-Muro, Emanuela Gualdi-Russo
Trepanation is one of the most ancient and applied surgical treatments; several archaeologically documented cases are known, dated back from Prehistory to the Middle ages. This case study reports the anthropological analysis of the skeletal remains of a young medieval woman and a fetus (Imola, Italy). The fetal remains were laid between her pelvis and lower limbs. A perforating injury was observed to her frontal bone. After assessing biological profiles, we attempted to interpret the injury and to reconstruct possible circumstances of death...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29449812/calycosin-orchestrates-osteogenesis-of-danggui-buxue-tang-in-cultured-osteoblasts-evaluating-the-mechanism-of-action-by-omics-and-chemical-knock-out-methodologies
#2
Amy G W Gong, Ran Duan, Huai Y Wang, Tina T X Dong, Karl W K Tsim
Danggui Buxue Tang (DBT), an ancient Chinese herbal decoction commonly used to mitigate menopausal osteoporosis, contains two herbs: Astragali Radix (AR) and Angelicae Sinensis Radix (ASR). The exact efficacy of individual chemical(s) within DBT, or in any herbal mixture, is hard to be revealed. Calycosin and ferulic acid have been reported to be the predominant chemicals found within DBT, and its roles in regulating osteoblastic differentiation have been proposed here. To probe the roles of calycosin and ferulic acid, these chemicals were specifically depleted from the DBT extracts...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29434774/tanshinone-iia-and-astragaloside-iv-promote-the-angiogenesis-of-mesenchymal-stem-cell-derived-endothelial-cell-like-cells-via-upregulation-of-cx37-cx40-and-cx43
#3
Zhe Li, Sha Zhang, Liang Cao, Wei Li, Yu-Chen Ye, Zi-Xuan Shi, Zong-Ren Wang, Lian-Xu Sun, Jia-Wei Wang, Lin-Tao Jia, Wen Wang
Tanshinone IIA (Tan IIA) and Astragaloside IV (AGS-IV) were used as therapeutic treatments for coronary heart diseases (CHDs) in ancient China. However, the underlying mechanisms mediating the effects of Tan IIA and AGS-IV in angiogenesis remain unknown. In the present study, mesenchymal stem cells (MSCs) were induced to differentiate into endothelial cell (EC)-like cells in vitro and the effects of Tan IIA and/or AGS-IV on the functions of these cells, including cell proliferation and tube formation, were assessed...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29427736/functional-analysis-of-a-type-2c-protein-phosphatase-gene-from-ammopiptanthus-mongolicus
#4
Lei Han, Junlin Li, Man Jin, Yanhua Su
In Arabidopsis and certain other plant species, the type 2C protein phosphatases (PP2Cs) of the clade A class have been demonstrated to act as negative regulators in ABA-induced stress responses, such as stomatal closure. The present study reports the identification of a PP2C ortholog from the ancient desert shrub Ammopiptanthus mongolicus (Maxim.) Cheng f. (AmPP2C), which is functionally conserved over its counterparts reported from other plant species. AmPP2C was primarily expressed in leaves, with strong transcriptional accumulation being observed in the guard cells...
February 7, 2018: Gene
https://www.readbyqxmd.com/read/29427634/mucuna-pruriens-l-dc-chemo-sensitize-human-breast-cancer-cells-via-downregulation-of-prolactin-mediated-jak2-stat5a-signaling
#5
Sonam Sinha, Sonal Sharma, Jaykant Vora, Heta Shah, Anshu Srivastava, Neeta Shrivastava
ETHNOPHARMACOLOGICAL RELEVANCE: Mucuna pruriens (L.) DC (MP) is an ancient Indian medicinal plant traditionally used to treat Parkinson's disease. L-Dopa (LD), precursor of dopamine is abundantly found in the seeds of MP. L-dopa is a natural inhibitor of prolactin (PRL) hormone which is required to maintain lactation in women but it's over production (hyperprolactinemia) plays critical role in advancement of breast cancer. AIM OF THE STUDY: We aim to examine the pharmacological effect of LD and MP on this hyperprolactinemia associated breast cancer and related signaling for effective management of the disease...
February 7, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29413627/an-unusual-strategy-of-stomatal-control-in-the-desert-shrub-ammopiptanthus-mongolicus
#6
Man Jin, Manyuan Guo, Guangzhen Yue, Junlin Li, Shunying Yang, Pengshu Zhao, Yanhua Su
Water deficit is one of the main environmental constraints that limit plant growth. Accordingly, plants evoke rather complex strategies to respond and/or acclimate to such frustrating circumstances. Due to insufficient understandings of acclimatory mechanisms of plants' tolerance to persistent water deficit, a desert shrub of an ancient origin, Ammopiptanthus mongolicus, has recently attracted growing attentions. Differed from Arabidopsis, the opening of stomata of A. mongolicus is constrained by low external K+ concentration of the guard cells...
January 30, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29408266/ancient-diversity-and-geographical-sub-structuring-in-african-buffalo-theileria-parva-populations-revealed-through-metagenetic-analysis-of-antigen-encoding-loci
#7
Johanneke D Hemmink, Tatjana Sitt, Roger Pelle, Lin-Mari de Klerk-Lorist, Brian Shiels, Philip G Toye, W Ivan Morrison, William Weir
An infection and treatment protocol involving infection with a mixture of three parasite isolates and simultaneous treatment with oxytetracycline is currently used to vaccinate cattle against Theileria parva. While vaccination results in high levels of protection in some regions, little or no protection is observed in areas where animals are challenged predominantly by parasites of buffalo origin. A previous study involving sequencing of two antigen-encoding genes from a series of parasite isolates indicated that this is associated with greater antigenic diversity in buffalo-derived T...
February 2, 2018: International Journal for Parasitology
https://www.readbyqxmd.com/read/29405039/a-review-of-the-use-of-pteridophytes-for-treating-human-ailments
#8
Xavier-Ravi Baskaran, Antony-Varuvel Geo Vigila, Shou-Zhou Zhang, Shi-Xiu Feng, Wen-Bo Liao
The aim of this review was to explore the pharmacological activity of early tracheophytes (pteridophytes) as an alternative medicine for treating human ailments. As the first vascular plants, pteridophytes (aka, ferns and fern allies) are an ancient lineage, and human beings have been exploring and using taxa from this lineage for over 2000 years because of their beneficial properties. We have documented the medicinal uses of pteridophytes belonging to thirty different families. The lycophyte Selaginella sp...
2018: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/29403630/an-overview-of-skin-lesions-adapted-to-cutaneous-leishmaniasis-in-persian-medicine
#9
REVIEW
Masoud Maleki, Mahdi Yousefi, Sayyed Mojtaba Mousavi Bazzaz, Sayyed Abolghasem Sajadi Tabassi, Hasan Rakhshandeh, Shokouh Sadat Hamedi, Gholamreza Haghighi
Background: Cutaneous Leishmaniasis (CL) which is prevalent in all continents and is classified by the WHO as one of the neglected tropical diseases, existed in the past also, and discovered ancient works confirm this issue. The lack of adaptation of diseases between Persian Medicine (PM) and Modern medicine, led to no usage of effective therapeutic experiences of prior physicians. Objective: The purpose of this study is finding skin lesions adapted to CL in PM for usage of same disease treatment in the next clinical trials, and the use of approved therapies in CL...
November 2017: Electronic Physician
https://www.readbyqxmd.com/read/29402116/rhazes-a-pioneer-in-contribution-to-trials-in-medical-practice
#10
REVIEW
Farzaneh Ghaffari, Mohsen Naseri, Razieh Jafari Hajati, Arman Zargaran
Medical history explains that Persian physicians used scientific methods based on clinical experiences and observations for treatment from pre-Islamic time (before 637 AD) and centuries later (in the Islamic era). Rhazes was one of the Persian physicians acknowledged as a pharmacist, chemist and prominent scientific writer on various subjects of medicine and philosophy. In this study, we aimed to investigate clinical experiences, as well as the ethical and critical views of Rhazes in medical practice. Rhazes promoted ethics in the medical profession...
December 2017: Acta Medico-historica Adriatica: AMHA
https://www.readbyqxmd.com/read/29396610/arsenic-trioxide-insights-into-its-evolution-to-an-anticancer-agent
#11
REVIEW
Maneka Hoonjan, Vaibhav Jadhav, Purvi Bhatt
Arsenic and its various forms have been in use in ancient Chinese medicine for more than 2000 years. Arsenicals have gained importance for having remedial effects for various diseases from syphilis to cancer thus highlighting its role as a therapeutic agent even though it has been labelled as a potential 'poison'. The ability of arsenic, specifically arsenic trioxide, to treat acute promyelocytic leukaemia has radically changed the perception of this poison and has been the main factor for the re-emergence of this candidate to Western medicine for the treatment of leukaemia and other solid tumours...
February 2, 2018: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29394026/medicinal-chemistry-of-gold-anticancer-metallodrugs
#12
Angela Casini, Raymond Wai-Yin Sun, Ingo Ott
Since ancient times gold and its complexes have been used as therapeutics against different diseases. In modern medicine gold drugs have been applied for the treatment of rheumatoid arthritis, however, recently other medical applications have come into the focus of inorganic medicinal chemistry. This chapter provides a non-comprehensive overview of key developments in the field of gold anticancer drugs. Exciting findings on gold(I) and gold(III) complexes as antitumor agents are summarized together with a discussion of relevant aspects of their modes of action...
February 5, 2018: Metal Ions in Life Sciences
https://www.readbyqxmd.com/read/29389854/mycobacterium-tuberculosis-molecular-determinants-of-infection-survival-strategies-and-vulnerable-targets
#13
REVIEW
Davide M Ferraris, Riccardo Miggiano, Franca Rossi, Menico Rizzi
Mycobacterium tuberculosis is the causative agent of tuberculosis, an ancient disease which, still today, represents a major threat for the world population. Despite the advances in medicine and the development of effective antitubercular drugs, the cure of tuberculosis involves prolonged therapies which complicate the compliance and monitoring of drug administration and treatment. Moreover, the only available antitubercular vaccine fails to provide an effective shield against adult lung tuberculosis, which is the most prevalent form...
February 1, 2018: Pathogens
https://www.readbyqxmd.com/read/29387905/-venereal-diseases-in-a-general-practice-in-the-17th-and-early-18th-centuries
#14
REVIEW
F Fries, H J Winckelmann
The diary of the town physician Johannes Franc (1649-1725), handwritten in Latin, gives-among other diseases-an overview of sexually transmitted infections affecting citizens in Ulm such as syphilis and gonorrhea. Franc reported on his own experiences in the diary and also included many theoretical details on the causes of the diseases and the corresponding therapies, including ethical considerations. Even in ancient times, there are indications of venereal diseases. However, at the latest with the outbreak of syphilis around the year 1495, the treatment and control of the spread of venereal diseases became an important task of medicine...
January 31, 2018: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29387831/the-effects-of-salvia-officinalis-l-on-granulosa-cells-and-in-vitro-maturation-of-oocytes-in-mice
#15
Malihezaman Monsefi, Akram Nadi, Zeinab Alinejad
Background: Salvia officinalisL. has been used since ancient times but there are little data about effects of this herb on normal reproductive cells. Objective: To investigate the toxicity effects of Salvia officinalis L. on granulosa cells (GCs) and maturation of oocytes. Materials and Methods: GCs and oocytes were extracted from superovulated ovaries of immature mice. The cells were treated with concentrations of 10, 50, 100, 500, and 1000 μg/ml of Salvia officinalis hydroalcoholic extracts and compared with the control culture...
October 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29383592/prayer-a-helpful-aid-in-recovery-from-depression
#16
Kirk A Johnson
Depression is a growing issue within the field of medicine. It negatively impacts individuals' lives and the people they are most connected to. For decades, medical professionals have been searching for solutions to assist those who are suffering from this illness. The use of drugs has not been a sufficient means of treatment to alleviate depression and its symptoms. There is a dire need to expand therapeutic interventions that can attribute meaningful recovery for victims of depression. One means of positive treatment is the use of prayer...
January 30, 2018: Journal of Religion and Health
https://www.readbyqxmd.com/read/29376970/-the-experimental-evaluation-of-the-protective-effect-of-the-extract-of-the-cyclodextrin-containing-phytotherapeutic-composition-on-the-development-of-osteoporosis
#17
M V Gordeev, E E Volkov, M S Izvolskaya, S N Voronova, A M Vasilenko
OBJECTIVE: The relevance of the problem considered in the present communication arises to-day from the widespread prevalence of osteoporosis (OP), the rather low effectiveness of the methods currently available for the treatment of this condition, and iatrogenic effects of its medication therapy. The great diversity of phytotherapeutic modalities of traditional medicine are is only poorly supported by the results of the scientific studies results; moreover, most of them are coming from the foreign literature publications...
December 5, 2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29372037/neuroprotective-effect-of-berberine-chloride-on-cognitive-impairment-and-hippocampal-damage-in-experimental-model-of-vascular-dementia
#18
Mahila Lotfi Aski, Mohammad Ebrahim Rezvani, Mehdi Khaksari, Zeynab Hafizi, Zeynab Pirmoradi, Somayeh Niknazar, Fatemeh Zare Mehrjerdi
Objectives: The major objective of the present study was to investigate the potential neuroprotective effect of berberine chloride on vascular dementia. Berberine, as an ancient medicine in China and India, is the main active component derived from the Berberis sp. Several studies have revealed the beneficial effects of berberine in various neurodegenerative disorders. Materials and Methods: To induce vascular dementia, chronic bilateral common carotid artery occlusion was performed on male Wistar rats...
January 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29369263/do-you-c-what-i-c-emergency-department-evaluation-and-diagnosis-of-pediatric-scurvy-in-an-autistic-child-with-a-restricted-diet
#19
James Burhop, Jennifer Gibson, Justin de Boer, Cyrus Heydarian
Scurvy in modern times may not be as rare as previously thought. The link between adequate intake of vitamin C and scurvy has been known since ancient times and is recorded in Ebers Papyrus. Recent reports indicate that, with restricted diets, vitamin C deficiency is being seen in infants exclusively fed plant-based formula and children with oral aversion, autism, restricted diets, and cerebral palsy. Additional at-risk groups include the older adults and patients having alcoholism. Often costly, emergency department visits and elaborate diagnostic studies lead to fruitless results when a simple diet history is often overlooked...
January 23, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29358486/cellular-energy-sensing-and-metabolism-implications-for-treating-diabetes-the-2017-outstanding-scientific-achievement-award-lecture
#20
Gregory R Steinberg
The Outstanding Scientific Achievement Award recognizes distinguished scientific achievement in the field of diabetes, taking into consideration independence of thought and originality. Gregory R. Steinberg, PhD, professor of medicine, Canada Research Chair, J. Bruce Duncan Endowed Chair in Metabolic Diseases, and codirector of the Metabolism and Childhood Obesity Research Program at McMaster University, Hamilton, Ontario, Canada, received the prestigious award at the American Diabetes Association's 77th Scientific Sessions, 9-13 June 2017, in San Diego, CA...
February 2018: Diabetes
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