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https://www.readbyqxmd.com/read/28725632/medicinal-importance-pharmacological-activities-and-analytical-aspects-of-hispidulin-a-concise-report
#1
REVIEW
Kanika Patel, Dinesh Kumar Patel
Herbal medicines have been played an important role in the human civilization since very ancient time as a food, cloth, medicine and other aspects. Some of the important drugs in the modern medicine were derived from the natural sources such as aspirin, digitalis, quinine, vincristine, vinblastine etc. Hispidulin (4', 5, 7-trihydroxy-6-methoxyflavone) is a flavones derivative found in plant such as Grindelia argentina, Arrabidaea chica, Saussurea involucrate, Crossostephium chinense, Artemisia and Salvia species...
July 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28721679/phytochemicals-as-potential-antidotes-for-targeting-nf-%C3%AE%C2%BAb-in-rheumatoid-arthritis
#2
REVIEW
R Kowshik Aravilli, S Laveen Vikram, V Kohila
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune destructive arthropathy prevalent among people in the age group of 40-70 years. RA induces severe pain, swelling and stiffness of joints resulting in bone damage. RA leads to reduced life expectancy when left untreated. RA is characterized by synovial hyperplasia, infiltration of inflammatory cells resulting in formation of pannus. Synovial hyperplasia is mediated by proinflammatory cytokines, notably IL-1 and TNF-α. NF-κB is a predominant transcription factor in amplifying the inflammatory response...
August 2017: 3 Biotech
https://www.readbyqxmd.com/read/28713754/a-rare-report-of-two-cases-ancient-schwannoma-of-infratemporal-fossa-and-verocay-schwannoma-of-buccal-mucosa
#3
Prerna Piyush, Sujata Mohanty, Sujoy Ghosh, Sunita Gupta
Schwannoma is a benign tumor that originates from Schwann cells of the peripheral nerve. Occurring as a common tumor in the head and neck region, its intraoral presentation is rare which accounts for only 1%. They are solitary, slow-growing, smooth-surfaced, usually asymptomatic, and encapsulated tumor. This paper comprises two case reports, both of which presented with an intraoral soft tissue swelling which turned out to be schwannoma of buccal mucosa and infratemporal fossa with extension into the oral cavity, respectively...
January 2017: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28712868/salicylates-promote-mitochondrial-biogenesis-by-regulating-the-expression-of-pgc-1%C3%AE-in-murine-3t3-l1-pre-adipocytes
#4
Yimin Yan, Xiaohong Yang, Tao Zhao, Yi Zou, Rui Li, Yancheng Xu
Mitochondrial dysfunction has been associated with insulin resistance and diabetes. Decreased mitochondrial density and mitochondrial copy numbers have been found in insulin-resistant individuals. Restoration of the number of mitochondria and normal mitochondrial function has become an important therapeutic target of diabetes. Salicylate, the main active ingredient in aspirin, has been in medicinal use since ancient times. Little information regarding the effects of salicylate on mitochondrial function has been reported...
July 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28707287/are-the-origins-of-precision-medicine-found-in-the-corpus-hippocraticum
#5
Meropi K Konstantinidou, Makrina Karaglani, Maria Panagopoulou, Aliki Fiska, Ekaterini Chatzaki
Precision medicine (PM) is currently placed at the center of global attention following decades of research towards the improvement of medical practice. The subject of this study was to examine whether this trend had emerged earlier, in fact if the fundamentals of PM can be traced back to the ancient Greek era. For this reason, we studied the collection of all the Hippocratic texts, called the Corpus Hippocraticum, using original translations, and attempted an interpretation of the ancient authors in the context of the modern concept of PM...
July 13, 2017: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/28707186/natural-oils-for-skin-barrier-repair-ancient-compounds-now-backed-by-modern-science
#6
REVIEW
Alexandra R Vaughn, Ashley K Clark, Raja K Sivamani, Vivian Y Shi
Natural plant oils are commonly used as topical therapy worldwide. They are usually easily accessible and are relatively inexpensive options for skin care. Many natural oils possess specific compounds with antimicrobial, antioxidant, anti-inflammatory, and anti-itch properties, making them attractive alternative and complementary treatments for xerotic and inflammatory dermatoses associated with skin-barrier disruption. Unique characteristics of various oils are important when considering their use for topical skin care...
July 13, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28701733/endosomal-nox2-oxidase-exacerbates-virus-pathogenicity-and-is-a-target-for-antiviral-therapy
#7
Eunice E To, Ross Vlahos, Raymond Luong, Michelle L Halls, Patrick C Reading, Paul T King, Christopher Chan, Grant R Drummond, Christopher G Sobey, Brad R S Broughton, Malcolm R Starkey, Renee van der Sluis, Sharon R Lewin, Steven Bozinovski, Luke A J O'Neill, Tim Quach, Christopher J H Porter, Doug A Brooks, John J O'Leary, Stavros Selemidis
The imminent threat of viral epidemics and pandemics dictates a need for therapeutic approaches that target viral pathology irrespective of the infecting strain. Reactive oxygen species are ancient processes that protect plants, fungi and animals against invading pathogens including bacteria. However, in mammals reactive oxygen species production paradoxically promotes virus pathogenicity by mechanisms not yet defined. Here we identify that the primary enzymatic source of reactive oxygen species, NOX2 oxidase, is activated by single stranded RNA and DNA viruses in endocytic compartments resulting in endosomal hydrogen peroxide generation, which suppresses antiviral and humoral signaling networks via modification of a unique, highly conserved cysteine residue (Cys98) on Toll-like receptor-7...
July 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/28701165/ethnomedicinal-and-cultural-practices-of-mammals-and-birds-in-the-vicinity-of-river-chenab-punjab-pakistan
#8
Muhammad Altaf, Arshad Javid, Muhammad Umair, Khalid Javed Iqbal, Zahid Rasheed, Arshad Mehmood Abbasi
BACKGROUND: Although, use of animal species in disease treatment and culture practices is as ancient as that of plant species; however ethnomedicinal uses and cultural values of animal species have rarely been reported. Present study is the first report on the medicinal uses of mammals and bird species in Pakistan. METHODS: Questionnaires and semi-structured interviews were applied to collect qualitative and quantitative data from local informants (N = 109). Relative frequency of mention (RFM), fidelity level (FL), relative popularity level (RPL), similarity index (SI) and rank order priority (ROP) indices were used to analyzed the data...
July 12, 2017: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/28696777/therapeutic-uses-of-triphala-in-ayurvedic-medicine
#9
Christine Tara Peterson, Kate Denniston, Deepak Chopra
AIM: The aim of this article is to review the current literature on the therapeutic uses and efficacy of Triphala. Herbal remedies are among the most ancient medicines used in traditional systems of healthcare such as Ayurveda. Triphala, a well-recognized and highly efficacious polyherbal Ayurvedic medicine consisting of fruits of the plant species Emblica officinalis (Amalaki), Terminalia bellerica (Bibhitaki), and Terminalia chebula (Haritaki), is a cornerstone of gastrointestinal and rejuvenative treatment...
July 11, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28694747/evaluation-of-central-and-peripheral-effects-of-doxepin-on-acetic-acid-induced-colitis-in-rat-and-the-involved-mechanisms
#10
Mohsen Zabihi, Valiollah Hajhashemi, Ardeshir Talebi, Mohsen Minaiyan
Anti-colitis effect of antidepressants has been demonstrated recently. Doxepin, a tricyclic antidepressant drug (TCA), with potent H1, H2, alpha1 adrenergic and muscarinic receptor blocking effects could be a good candidate for investigation for its anti-colitis activity. Moreover high prevalence of depression in patients who suffer from IBD (inflammatory bowel disease), defends this idea that adjuvant therapy with an antidepressant drug which has anti-inflammatory effect, may exert favorable effects in the control of the disease...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28690677/the-past-and-future-of-breast-cancer-treatment-from-the-papyrus-to-individualised-treatment-approaches
#11
REVIEW
Felipe Ades, Konstantinos Tryfonidis, Dimitrios Zardavas
Cancer is one of the oldest diseases ever described, since ancient Egypt there have always been attempts to treat and cure this illness. The growing body of knowledge about breast cancer biology and improvements in surgical and medical treatments has been built over time with contributions from many talented and enthusiastic physicians and researchers. Medical advances have changed the approach from a previously incurable condition, into a surgical disease. Further improvements in cancer biology have allowed the development of systemic treatments, hormonal therapies, and targeted drugs...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28683902/a-history-of-thoracic-aortic-surgery
#12
REVIEW
Paul Michael McFadden, Luke M Wiggins, Joshua A Boys
Ancient historical texts describe the presence of aortic pathology conditions, although the surgical treatment of thoracic aortic disease remained insurmountable until the 19th century. Surgical treatment of thoracic aortic disease then progressed along with advances in surgical technique, conduit production, cardiopulmonary bypass, and endovascular technology. Despite radical advances in aortic surgery, principles established by surgical pioneers of the 19th century hold firm to this day.
August 2017: Cardiology Clinics
https://www.readbyqxmd.com/read/28683189/development-of-a-uhplc-ms-ms-method-for-the-quantitation-of-bioactive-compounds-in-phyllanthus-species-and-its-herbal-formulations
#13
Sunil Kumar, Awantika Singh, Vikas Bajpai, Bikarma Singh, Brijesh Kumar
Phyllanthus species are extensively used in traditional medicines for the treatment of hepatic diseases due to their bioactive hypophyllanthin and phyllanthin since ancient times. This work describes the development and validation of an ultra high performance liquid chromatography with tandem mass spectrometry method in polarity switching multiple reaction monitoring mode for the simultaneous detection and quantitation of 23 compounds using ultra performance liquid chromatography coupled with electrospray-hybrid triple quadrupole-linear ion trap mass spectrometer...
July 6, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28678860/multi-scale-ancient-dna-analyses-confirm-the-western-origin-of-michelsberg-farmers-and-document-probable-practices-of-human-sacrifice
#14
Alice Beau, Maïté Rivollat, Hélène Réveillas, Marie-Hélène Pemonge, Fanny Mendisco, Yohann Thomas, Philippe Lefranc, Marie-France Deguilloux
In Europe, the Middle Neolithic is characterized by an important diversification of cultures. In northeastern France, the appearance of the Michelsberg culture has been correlated with major cultural changes and interpreted as the result of the settlement of new groups originating from the Paris Basin. This cultural transition has been accompanied by the expansion of particular funerary practices involving inhumations within circular pits and individuals in "non-conventional" positions (deposited in the pits without any particular treatment)...
2017: PloS One
https://www.readbyqxmd.com/read/28663700/interleukin-6-expression-on-inflamed-rat-dental-pulp-tissue-after-capped-with-trigona-sp-propolis-from-south-sulawesi-indonesia
#15
Ardo Sabir, Andi Sumidarti
Background: Propolis is a natural product of plant resins collected by honeybees from various plant sources. It is used as a remedy in folk medicine since ancient times because of its several biological and pharmacological properties. Recently, propolis has been used by dentist to treat various oral diseases. It was always mentioned as an anti-inflammatory agent. Cytokines are proteins that provide communication between cells and play a critical role in a wide variety of processes. It released from cells in an inflammatory process that active, mediate or potential actions of other cells or tissues...
July 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28661073/squamous-neoplasms-arising-within-tattoos-clinical-presentation-histopathology-and-management
#16
REVIEW
A L Junqueira, K A Wanat, R S Farah
Tattooing, which involves the placement of ink into the skin, is an ancient decorative technique that has remained popular in modern society. Tattoos have long been known to cause cutaneous reactions, which include the emergence of neoplasms such as keratoacanthoma (KA) and squamous cell carcinoma (SCC) in tattooed areas of the skin. We review the clinical presentations, histology and treatment options for squamous neoplasms, primarily KA and SCC, arising in tattoos.
June 29, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28650591/the-silver-lining-towards-the-responsible-and-limited-usage-of-silver
#17
REVIEW
Kshipra Naik, Meenal Kowshik
Silver has attracted a lot of attention as a powerful, broad spectrum and natural antimicrobial agent since the ancient times because of its non-toxic nature to the human body at low concentrations. It has been used in treatment of various infections and ulcers, storage of water, and prevention of bacterial growth on the surfaces and within materials. However there are numerous medical and health benefits of colloidal or nano silver apart from its microbicidal ability which as yet have not been fully embraced by the medical community...
June 26, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28646813/hepatoprotective-activity-of-satwa-an-ayurvedic-formulation-against-alcohol-induced-liver-injury-in-rats
#18
Tejaswi Chavan, Abhijit Ghadge, Manjiri Karandikar, Vijaya Pandit, Prabhakar Ranjekar, Omkar Kulkarni, Aniket Kuvalekar, Nitin Mantri
Context • Guduchi Satwa is an Ayurvedic formulation prepared from Tinospora species. It has been used since ancient times to treat liver disorders. Objectives • The study intended to assess the hepatoprotective potential of Satwa prepared from 3 forms of Tinospora against alcohol-induced hepatotoxicity. Design • Male, albino Wistar rats were divided into 6 groups, with 6 rats each: 3 control groups-healthy controls, negative controls, and positive controls-and 3 intervention groups-Tinospora cordifolia, Tinospora sinensis, and Neem-Guduchi...
July 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28646808/traditional-uyghur-medicine-concepts-historical-perspective-and-modernization
#19
Adelijang Wusiman, Saifuding Abula, Mikeremu Shayibuzhati, Xiaoying Zhang
Context • Traditional Uyghur medicine (TUM) is rooted in ancient Uyghur medical theory that was developed with the combined essence of different traditional medicines, such as Han Chinese, Egyptian, ancient Greek, Arabian, Persian, and Indian medicines. Modern experimental methods and technologies for disease diagnoses have accelerated the modernization of Uyghur medicine. Objective • The research team intended to compile a comprehensive introduction to TUM and to determine the current state of research in the field to establish a basis for future modernization of Uygur medicine...
June 23, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28643945/athens-based-meeting-to-discuss-the-paediatric-virology-crossroad-in-october-2017
#20
Ioannis N Mammas, Demetrios A Spandidos
Viral infections are common diseases and they are well-described in the Ancient Greek Hippocratic Corpus (1), together with a limited spectrum of diagnostic and treatment options. However, over the past two decades, several exciting developments in the fields of clinical virology and molecular medicine have expanded our knowledge on the pathogenesis of viral infections in neonates and children (2,3). Since 2015, the workshop on paediatric virology has tried enthusiastically to explore these advances and to investigate recent challenges in the prevention strategies, molecular diagnostics, multimodality imaging and therapeutics of paediatric viral infections (2-5)...
June 23, 2017: Acta Paediatrica
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