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https://www.readbyqxmd.com/read/29217495/efficacy-of-violet-oil-a-traditional-iranian-formula-in-patients-with-chronic-insomnia-a-randomized-double-blind-placebo-controlled-study
#1
Zohre Feyzabadi, Fariborz Rezaeitalab, Shapour Badiee, Ali Taghipour, Fatemeh Moharari, Atefeh Soltanifar, Mohammad Reza Ahmadpour
ETHNOPHARMACOLOGICAL RELEVANCE: Violet oil is an ancient herbal drug which has been extensively used to treat insomnia in traditional Iranian Medicine clinics. Violet oil is an almond or sesame oil-based extract of Viola odorata, which is administered as nasal drops. This study aimed to evaluate the efficacy of Violet oil in the treatment of insomnia. METHODS AND MATERIALS: This study was conducted as a 3-arm double-blind randomized trial. A total of 75 patients with chronic insomnia were enrolled and randomly assigned to three groups in Traditional Iranian Medicine Clinic of Mashhad University of Medical Sciences, Mashhad, Iran...
December 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29209026/qskl-protects-against-myocardial-apoptosis-on-heart-failure-via-pi3k-akt-p53-signaling-pathway
#2
Hong Chang, Chun Li, Qiyan Wang, Linghui Lu, Qian Zhang, Yi Zhang, Na Zhang, Yong Wang, Wei Wang
The ancient traditional Chinese medicine Qishenkeli (QSKL) is widely used in the treatment of heart failure (HF) in China. Previous studies have shown that QSKL has definite effects on HF. The purpose of this study is to identify the regulation of QSKL on apoptosis and clarify the underlying mechanism. An apoptosis model of H9C2 cells was induced by oxygen-glucose deprivation/recovery (OGD/R). An animal model of HF was induced by ligation of left anterior descending (LAD) coronary artery in rat. We found that QSKL reduced intracellular ROS generation, increased mitochondrial membrane potential and protected H9C2 cells against OGD/R-induced apoptosis...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29208504/hepatoprotective-effects-of-garlic-against-ethanol-induced-liver-injury-a-mini-review
#3
REVIEW
Min-Jie Guan, Ning Zhao, Ke-Qin Xie, Tao Zeng
Alcoholic liver disease (ALD) is a progressively aggravated liver disease with a diverse spectrum from steatosis to hepatitis, fibrosis, and cirrhosis. Epidemiological studies reveal that alcohol is one of the major causes of advanced liver disease in Europe, United States, and China. Despite the considerable harm, progression in ALD research is slow and the current therapies for ALD have less efficient. Garlic (Allium sativum) has been used as a flavoring agent and also a folk medicine since ancient time. Along with the prosperity in the use of herbal medicines for the treatment of human diseases in recent decades, a series of studies have focused on the beneficial effects of garlic against ALD...
December 2, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29203753/-definition-and-treatment-of-stroke-over-the-centuries
#4
Anna Starostka-Tatar, Beata Łabuz-Roszak, Michał Skrzypek, Mariusz Gąsior, Marek Gierlotka
Stroke was already diagnosed in the ancient times. For hundreds of years the treatment of this disease has changed radically. According to the current WHO definition, stroke is a clinical syndrome caused by focal or generalized brain injury that lasts more than 24 hours or leads to death and has no other cause than vascular. Stroke constitutes a big social and economic problem, as it can lead to death or disability. In the highly developed countries stroke is the third most common cause of adult deaths, the second leading cause of dementia, and the most common cause of disability...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29203441/therapeutic-targeting-of-oncogenic-transcription-factors-by-natural-products-in-eye-cancer
#5
REVIEW
Michelle G Zhang, John Y Lee, Ryan A Gallo, Wensi Tao, David Tse, Ravi Doddapaneni, Daniel Pelaez
Carcinogenesis has a multifactorial etiology, and the underlying molecular pathogenesis is still not entirely understood, especially for eye cancers. Primary malignant intraocular neoplasms are relatively rare, but delayed detection and inappropriate management contribute to poor outcomes. Conventional treatment, such as orbital exenteration, chemotherapy, or radiotherapy, alone results in high mortality for many of these malignancies. Recent sequential multimodal therapy with a combination of high-dose chemotherapy, followed by appropriate surgery, radiotherapy, and additional adjuvant chemotherapy has helped dramatically improve management...
December 1, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29198280/alzheimer-s-disease-past-present-and-future
#6
Mark W Bondi, Emily C Edmonds, David P Salmon
Although dementia has been described in ancient texts over many centuries (e.g., "Be kind to your father, even if his mind fail him." - Old Testament: Sirach 3:12), our knowledge of its underlying causes is little more than a century old. Alzheimer published his now famous case study only 110 years ago, and our modern understanding of the disease that bears his name, and its neuropsychological consequences, really only began to accelerate in the 1980s. Since then we have witnessed an explosion of basic and translational research into the causes, characterizations, and possible treatments for Alzheimer's disease (AD) and other dementias...
October 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29175802/review-ethnomedicinal-phytochemical-and-antibacterial-activities-of-medicinal-flora-of-pakistan-used-against-pseudomonas-aeruginosa-a-review
#7
Roqaia Bibi, Akash Tariq, Sakina Mussarat, Shahid Niaz Khan, Hazir Rahman, Elsayed Fathi Abd Allah, Riaz Ullah, Muhammad Adnan
Medicinal plants have been used from ancient time against different infectious diseases caused by microorganisms across the globe. The present review represents different medicinal plants of Pakistan used traditionally for the treatment of variety of ailments caused by Pseudomonas aeruginosa, their in-vitro activities against P. aeruginosa and phytochemistry. These plants were extracted with different solvents that showed good in-vitro activities against P. aeruginosa, due to the presence of active phytoconstituents including alkaloids, terpenoids etc...
November 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29173187/trichinella-spiralis-and-tumors-cause-coincidence-or-treatment
#8
Chengshui Liao, Xiangchao Cheng, Mingyuan Liu, Xuelin Wang, Pascal Boireau
Conventional therapeutic strategies for tumors have had limited success, and innovative and more effective approaches to treatment are urgently required. The ancient idea that various biological, bacterial, yeast, viral, and parasitic agents can be used as cancer therapeutics has gradually attracted considerable interest. Certain parasites have been widely discussed in association with human and animal tumors. Many researches have provided proofs that Trichinella spiralis (T. spiralis) possesses antitumor activities...
November 20, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29167511/transcription-factor-nf-%C3%AE%C2%BAb-is-modulated-by-symbiotic-status-in-a-sea-anemone-model-of-cnidarian-bleaching
#9
Katelyn M Mansfield, Nicole M Carter, Linda Nguyen, Phillip A Cleves, Anar Alshanbayeva, Leah M Williams, Camerron Crowder, Ashley R Penvose, John R Finnerty, Virginia M Weis, Trevor W Siggers, Thomas D Gilmore
Transcription factor NF-κB plays a central role in immunity from fruit flies to humans, and NF-κB activity is altered in many human diseases. To investigate a role for NF-κB in immunity and disease on a broader evolutionary scale we have characterized NF-κB in a sea anemone (Exaiptasia pallida; called Aiptasia herein) model for cnidarian symbiosis and dysbiosis (i.e., "bleaching"). We show that the DNA-binding site specificity of Aiptasia NF-κB is similar to NF-κB proteins from a broad expanse of organisms...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29163551/host-antimicrobial-peptides-the-promise-of-new-treatment-strategies-against-tuberculosis
#10
REVIEW
Javier Arranz-Trullén, Lu Lu, David Pulido, Sanjib Bhakta, Ester Boix
Tuberculosis (TB) continues to be a devastating infectious disease and remerges as a global health emergency due to an alarming rise of antimicrobial resistance to its treatment. Despite of the serious effort that has been applied to develop effective antitubercular chemotherapies, the potential of antimicrobial peptides (AMPs) remains underexploited. A large amount of literature is now accessible on the AMP mechanisms of action against a diversity of pathogens; nevertheless, research on their activity on mycobacteria is still scarce...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29158323/fgf8-morphogen-gradients-are-differentially-regulated-by-heparan-sulphotransferases-hs2st-and-hs6st1-in-the-developing-brain
#11
Wai-Kit Chan, David J Price, Thomas Pratt
Fibroblast growth factor (FGF) morphogen signalling through the evolutionarily ancient Extracellular signaling Regulated Kinase/Mitogen Activated Protein Kinase (ERK/MAPK) pathway recurs in many neural and non-neural developmental contexts and understanding the mechanisms that regulate FGF/ERK function are correspondingly important. The glycosaminoglycan heparan sulphate (HS) binds to FGFs and exists in an enormous number of differentially sulphated forms produced by the action of HS modifying enzymes so has the potential to present an extremely large amount of information in FGF/ERK signalling...
November 20, 2017: Biology Open
https://www.readbyqxmd.com/read/29142540/clinical-audit-of-dengue-related-deaths-in-2011-mayo-hospital-lahore-pakistan
#12
Somia Iqtadar, Nabeel Akbar, Mehreen Mehmood, Sajid Abaidullah
Background and Objective: Dengue infection has evolved into an epidemic during last few years in Pakistan and has been associated with poor outcomes. Literature with respect to mortality risk factors in Dengue infection is not sufficient. This compelled us to conduct this study to find out major contributory factors to death in patients with dengue viral infection at one of Asia's ancient hospital setting with an aim to recognize complications at earliest and improve case management in future...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29138800/broadleaf-mahonia-attenuates-granulomatous-lobular-mastitis%C3%A2-associated-inflammation-by-inhibiting-ccl%C3%A2-5-expression-in-macrophages
#13
Zhiyu Wang, Neng Wang, Xiaoyan Liu, Qi Wang, Biao Xu, Pengxi Liu, Huayu Zhu, Jianping Chen, Honglin Situ, Yi Lin
Granulomatous lobular mastitis (GLM) is a type of chronic mammary inflammation with unclear etiology. Currently systematic corticosteroids and methitrexate are considered as the main drugs for GLM treatment, but a high toxicity and risk of recurrence greatly limit their application. It is therefore an urgent requirement that safe and efficient natural drugs are found to improve the GLM prognosis. Broadleaf Mahonia (BM) is a traditional Chinese herb that is believed to have anti‑inflammatory properties according to ancient records of traditional Chinese medicine...
November 9, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29133027/nutrient-analysis-of-kunapa-jala-and-pancha-gavya-and-their-evaluation-on-germination-of-ashwagandha-withania-somnifera-dunal-and-kalamegha-andrographis-paniculata-nees-seeds-a-comparative-study
#14
Gireesh M Ankad, Jagadishchandra Hiremath, R T Patil, H J Pramod, Harsha V Hegde
BACKGROUND: Vrikshayurveda, an ancient science of plant life described by Surapala, deals with healthy growth and productivity of plants, which has clearly outlined a systematized agricultural practice that insisted the use of Kunapa jala (KJ) and Pancha gavya (PG). OBJECTIVE: An experiment was conducted to validate KJ and PG by nutrient analysis and their effect on the germination parameters of Ashwagandha and Kalamegha seeds in comparison with other treatment groups...
November 10, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29130595/naphthoquinones-a-continuing-source-for-discovery-of-therapeutic-antineoplastic-agents
#15
REVIEW
Han-Yue Qiu, Peng-Fei Wang, Hong-Yan Lin, Cheng-Yi Tang, Hai-Liang Zhu, Yong-Hua Yang
Naturally occurring naphthoquinones, usually in forms of botanical extracts, have been implicated with human life since ancient time, far earlier than their isolation and identification in modern era. The long use history of naphthoquinones has witnessed their functional shift from the original purposes as dyes and ornaments towards medicinal benefits. Hitherto, numerous studies have been carried out to elucidate the pharmacological profile of both natural and artificial naphthoquinones. A number of entities have been identified with promising therapeutic potential...
November 11, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29117184/from-songlines-to-genomes-prehistoric-assisted-migration-of-a-rain-forest-tree-by-australian-aboriginal-people
#16
Maurizio Rossetto, Emilie J Ens, Thijs Honings, Peter D Wilson, Jia-Yee S Yap, Oliver Costello, Erich R Round, Claire Bowern
BACKGROUND: Prehistoric human activities have contributed to the dispersal of many culturally important plants. The study of these traditional interactions can alter the way we perceive the natural distribution and dynamics of species and communities. Comprehensive research on native crops combining evolutionary and anthropological data is revealing how ancient human populations influenced their distribution. Although traditional diets also included a suite of non-cultivated plants that in some cases necessitated the development of culturally important technical advances such as the treatment of toxic seed, empirical evidence for their deliberate dispersal by prehistoric peoples remains limited...
2017: PloS One
https://www.readbyqxmd.com/read/29116294/secondary-syphilis-presenting-as-leucoderma-syphiliticum-case-report-and-review
#17
Walter de Araujo Eyer-Silva, Carlos José Martins, Guilherme Almeida Rosa da Silva, Giresse Acakpovi, Jorge Francisco da Cunha Pinto
Leucoderma syphiliticum (LS), originally described as syphilide pigmentaire, encompasses a spectrum of dyschromic lesions that emerge during the course of secondary syphilis. Very few case reports are available in modern biomedical databases. We present the case of a 57-year-old HIV-infected male patient who presented with several round to oval, non-scaling, slightly raised and well-demarcated hypochromic lesions scattered over the trunk, abdomen, dorsum, and arms. Prior non-treponemal tests were negative for syphilis, but novel studies yielded positive results at high titers...
November 6, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/29111156/genetics-of-human-susceptibility-to-active-and-latent-tuberculosis-present-knowledge-and-future-perspectives
#18
REVIEW
Laurent Abel, Jacques Fellay, David W Haas, Erwin Schurr, Geetha Srikrishna, Michael Urbanowski, Nimisha Chaturvedi, Sudha Srinivasan, Daniel H Johnson, William R Bishai
Tuberculosis is an ancient human disease, estimated to have originated and evolved over thousands of years alongside modern human populations. Despite considerable advances in disease control, tuberculosis remains one of the world's deadliest communicable diseases with 10 million incident cases and 1·8 million deaths in 2015 alone based on the annual WHO report, due to inadequate health service resources in less-developed regions of the world, and exacerbated by the HIV/AIDS pandemic and emergence of multidrug-resistant strains of Mycobacterium tuberculosis...
October 27, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29105633/evaluation-of-antimicrobial-cytotoxic-and-genotoxic-activities-of-ganoderma-lucidum-reishi-mushroom
#19
Bulent Ergun
Ganoderma lucidum (GL) is a mushroom used as a traditional remedy for the treatment of various infections since ancient times. This study, was aimed to investigate antimicrobial activity potential of GL against Staphylococcus aureus, Enterococcus faecalis, Listeria monocytogenes, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, Candida glabrata, Candida krusei, and Candida parapsilopsis. Furthermore, it was also aimed to evaluate the toxicity potential of GL. Antimicrobial activities were screened by using microbroth dilution method...
September 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29102765/can-highly-cited-herbs-in-ancient-traditional-chinese-medicine-formulas-and-modern-publications-predict-therapeutic-targets-for-diabetes-mellitus
#20
Huijun Wang, Songshan Shi, Shunchun Wang
ETHNOPHARMACOLOGICAL RELEVANCE: The prevalence of diabetes among all age groups worldwide was estimated to be more than 382 million in 2013. Traditional Chinese medicine (TCM) has been practiced for thousands of years, and substantial valuable experience and prescriptions have been accumulated in the TCM system for the treatment of diabetes. In recent decades, a large amount of experimental and clinical data has been published on the use of herbal medicines related to these ancient TCM prescriptions...
November 2, 2017: Journal of Ethnopharmacology
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