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https://www.readbyqxmd.com/read/29156807/halofuginone-inhibits-tgf-%C3%AE-bmp-signaling-and-in-combination-with-zoledronic-acid-enhances-inhibition-of-breast-cancer-bone-metastasis
#1
Patricia Juárez, Pierrick G J Fournier, Khalid S Mohammad, Ryan C McKenna, Holly W Davis, Xiang H Peng, Maria Niewolna, Alain Mauviel, John M Chirgwin, Theresa A Guise
More efficient therapies that target multiple molecular mechanisms are needed for the treatment of incurable bone metastases. Halofuginone is a plant alkaloid-derivative with antiangiogenic and antiproliferative effects. Here we demonstrate that halofuginone is an effective therapy for the treatment of bone metastases, through multiple actions that include inhibition of TGFβ and BMP-signaling. Halofuginone blocked TGF-β-signaling in MDA-MB-231 and PC3 cells showed by inhibition of TGF-β-induced Smad-reporter, phosphorylation of Smad-proteins, and expression of TGF-β-regulated metastatic genes...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156537/ursolic-acid-ameliorates-oxidative-stress-inflammation-and-fibrosis-in-diabetic-cardiomyopathy-rats
#2
Xu-Tao Wang, Yan Gong, Bin Zhou, Jun-Jie Yang, Yin Cheng, Jin-Guo Zhao, Min-You Qi
Diabetic cardiomyopathy is a major and severe cardiovascular complication of diabetes mellitus. Ursolic acid, a pentacyclic triterpene compound widespread in fruits and plants, performs a variety of pharmacological activities including lowering blood glucose, anti-oxidation, anti-inflammation and anti-fibrosis. Our present study aimed to investigate the cardioprotective effects of ursolic acid on diabetic cardiomyopathy rats and uncover its underlying mechanism. Diabetes mellitus was induced by a single injection of STZ-only (40 mg/ kg, i...
November 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29156440/pharmaceutical-and-personal-care-products-induced-stress-symptoms-and-detoxification-mechanisms-in-cucumber-plants
#3
Chengliang Sun, Stacia Dudley, John Trumble, Jay Gan
Contamination of agricultural soils by pharmaceutical and personal care products (PPCPs) resulting from the application of treated wastewater, biosolids and animal wastes constitutes a potential environmental risk in many countries. To date a handful of studies have considered the phytotoxicity of individual PPCPs in crop plants, however, little is known about the effect of PPCPs as mixtures at environmentally relevant levels. This study investigated the uptake and transport, physiological responses and detoxification of a mixture of 17 PPCPs in cucumber seedlings...
November 17, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29156437/home-composting-using-different-ratios-of-bulking-agent-to-food-waste
#4
Lucas Lourenço Castiglioni Guidoni, Roger Vasques Marques, Rodrigo Bilhalva Moncks, Fabiana Torma Botelho, Matheus Francisco da Paz, Luciara Bilhalva Corrêa, Érico Kunde Corrêa
The negative environmental impacts associated with home composting may be due to the absence of a defined operation criteria for the degradation process. In addition to the potentially low environmental impact in terms of energy and water usage, which is minimal to the manufacture of the composting unit and avoiding the processing and transportation of waste or byproduct, composting at home can also promote a reduction in the emission of unpleasant gases. The proportion of the food waste and bulking agents in the composting mixture may be decisive to fulfill good practices of waste stabilization...
November 17, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29156332/effective-flocculation-of-microcystis-aeruginosa-with-simultaneous-nutrient-precipitation-from-hydrolyzed-human-urine
#5
Yan-Shan Wang, Zhong-Hua Tong, Long-Fei Wang, Guo-Ping Sheng, Han-Qing Yu
Mechanical harvest of massive harmful algal blooms is an effective measure for bloom mitigation. Yet subsequent processing of the resulting water from algae water separation after the harvesting becomes a new problem since individual algal cells or small algal aggregates are still present in the water. Here, we proposed a novel approach for effectively flocculating the cyanobacteria Microcystis aeruginosa with a removal efficiency of 97% in 6 h using hydrolyzed urine. Nitrogen and phosphorus were simultaneously reclaimed through struvite formation...
November 11, 2017: Chemosphere
https://www.readbyqxmd.com/read/29156303/assessment-of-nickel-bioavailability-through-chemical-extractants-and-red-clover-trifolium-pratense-l-in-an-amended-soil-related-changes-in-various-parameters-of-red-clover
#6
Ali Khan Shahbaz, Muhammad Iqbal, Abdul Jabbar, Sabir Hussain, Muhammad Ibrahim
Application of immobilizing agents may efficiently reduce the bioavailability of nickel (Ni) in the soil. Here we report the effect of biochar (BC), gravel sludge (GS) and zeolite (ZE) as a sole treatment and their combinations on the bioavailability of Ni after their application into a Ni-polluted soil. The bioavailability of Ni after the application of immobilizing agents was assessed through an indicator plant (red clover) and chemical indicators of bioavailability like soil water extract (SWE), DTPA and Ca(NO3)2 extracts...
November 17, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29156276/formation-and-degradation-of-n-oxide-venlafaxine-during-ozonation-and-biological-post-treatment
#7
Ines Zucker, Hadas Mamane, Alon Riani, Igal Gozlan, Dror Avisar
While ozonation is considered an efficient treatment to eliminate trace organic compounds (TrOCs) from secondary wastewater effluents, the presence and persistence of transformation products (TPs) resulting from ozonation of TrOCs is a major concern that should be assessed prior to effluent discharge to the environment. Venlafaxine (VLX), an environmentally relevant tertiary amine-containing TrOC, was chosen as the model for this study. TP analysis confirmed that the lone electron pair of the non-protonated amine are the predominant site of oxidant attack, and therefore strongly affected by pH value and VLX speciation...
November 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29156265/occurrence-and-fate-of-most-prescribed-antibiotics-in-different-water-environments-of-tehran-iran
#8
Roya Mirzaei, Masud Yunesian, Simin Nasseri, Mitra Gholami, Esfandiyar Jalilzadeh, Shahram Shoeibi, Alireza Mesdaghinia
The presence of most prescribed antibiotic compounds from four therapeutic classes (β-lactam, cephalosporins, macrolides, fluoroquinolones) were studied at two full-scale WWTPs, two rivers, thirteen groundwater resources, and five water treatment plants in Tehran. Analytical methodology was based on high performance liquid chromatography/tandem mass spectrometry after solid-phase extraction. Samples were collected at 33 sample locations on three sampling periods over four months from June to August 2016. None of the target antibiotics were detected in groundwater resources and water treatment plants, while seven out of nine target antibiotics were analyzed in two studied river waters as well as the influent and effluent of wastewater treatment plants at concentrations ranging from <LOQ to 926...
November 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29156230/transport-of-a-neonicotinoid-pesticide-thiamethoxam-from-artificial-seed-coatings
#9
Jesse Radolinski, Junxue Wu, Kang Xia, Ryan Stewart
Neonicotinoid insecticides coat the seeds of major crops worldwide; however, the high solubility of these compounds, combined with their toxicity to non-target organisms, makes it critical to decipher the processes by which they are transported through soils and into aquatic environments. Transport and distribution of a neonicotinoid (thiamethoxam, TMX) were investigated by growing TMX-coated corn seeds in coarse-textured and fine-textured soil columns (20 and 60cm lengths). To understand the influence of living plants, corn plants were terminated in half of the columns (no plant treatment) and allowed to grow to the V5 growth stage (33days of growth) in the other half (with plant treatment)...
November 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29155872/sulfur-dioxide-alleviates-programmed-cell-death-in-barley-aleurone-by-acting-as-an-antioxidant
#10
Sha-Sha Wang, Ying-Xin Zhang, Feng Yang, Zhong-Qin Huang, Jun Tang, Kang-Di Hu, Hua Zhang
Sulfur dioxide (SO2), a gaseous signaling molecule in animal cells, has recently been found to play a physiological role in plants. Here we studied the role of SO2 in gibberellic acid (GA3)-induced programmed cell death (PCD) in barley (Hordeum vulgare L.) aleurone layers. The application of the SO2 donor (NaHSO3/Na2SO3, 1:3 M/M) effectively alleviated PCD in barley aleurone layers in a dose-dependent manner with an optimal concentration of 50 μM. Further investigations showed that SO2 reduced the accumulation of hydrogen peroxide (H2O2), superoxide anion (⋅O2-) and malondialdehyde (MDA) in aleurone layers...
2017: PloS One
https://www.readbyqxmd.com/read/29155825/poverty-and-health-among-cdc-plantation-labourers-in-cameroon-perceptions-challenges-and-coping-strategies
#11
Valerie Makoge, Lenneke Vaandrager, Harro Maat, Maria Koelen
Creating better access to good quality healthcare for the poor is a major challenge to development. In this study, we examined inter-linkages between poverty and disease, referred to as poverty-related diseases (PRDs), by investigating how Cameroon Development Corporation (CDC) camp dwellers respond to diseases that adversely affect their health and wellbeing. Living in plantation camps is associated with poverty, overcrowding, poor sanitation and the rapid spread of diseases. In a survey of 237 CDC camp dwellers in Cameroon, we used the health belief model to understand the drivers (perceived threats, benefits and cues for treatment seeking) of reported responses...
November 20, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29155575/temporal-trends-of-c8-c36-chlorinated-paraffins-in-swedish-coastal-sediment-cores-over-the-past-80-years
#12
Bo Yuan, Volker Brüchert, Anna Sobek, Cynthia A de Wit
Temporal trends of chlorinated paraffins (CPs) were analyzed in three sediment cores collected near different potential CP sources along the Swedish Baltic Sea coast. C8-C36 CPs were found in sediment dating back to the 1930s. The maximum CP concentrations found in proximity to a metropolitan sewage treatment plant, a wood-related industrial area, and a steel factory were 48, 160, and 1400 ng/g d.w., respectively, in sediment sections dated from the early 1990s or the 2000s. The temporal trends agree with statistics on CP importation in Sweden or local industrial activities...
November 20, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29155489/priming-of-cowpea-volatile-emissions-with-defense-inducers-enhances-the-plant-s-attractiveness-to-parasitoids-when-attacked-by-caterpillars
#13
Islam S Sobhy, Toby J A Bruce, Ted C J Turlings
BACKGROUND: The manipulation of herbivore-induced volatile organic compounds (HI-VOCs) via the application of the inducers BTH [benzo (1,2,3) thiadiazole-7-carbothioic acid S-methyl ester] and Laminarin [β-1,3-glucan] is known to enhance the attractiveness of caterpillar-damaged cotton and maize plants to parasitoids. To test if this is also the case for legumes, we treated cowpea with these inducers and studied the effects on HI-VOC emissions and the attraction of three generalist endoparasitoids...
November 20, 2017: Pest Management Science
https://www.readbyqxmd.com/read/29155478/alternative-polyadenylation-is-involved-in-auxin-based-plant-growth-and-development
#14
Liwei Hong, Congting Ye, Juncheng Lin, Haihui Fu, Xiaohui Wu, Qingshun Q Li
Auxin is widely involved in plant growth and development. However, the molecular mechanism on how auxin carries out this work is unclear. In particular, impact of auxin on pre-mRNA posttranscriptional regulation is mostly unknown. By using a poly(A) tag (PAT) sequencing approach, mRNA alternative polyadenylation (APA) profiles after auxin treatment were revealed. We showed that hundreds of poly(A) site clusters (PACs) are affected by auxin at the transcriptome level, where auxin reduces PAC distribution in 5'UTR, but increases in 3'UTR...
November 20, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29155390/biosynthesised-silver-and-copper-nanoformulation-as-foliar-spray-to-control-bird-s-eye-spot-disease-in-tea-plantations
#15
Balasubramanian Mythili Gnanamangai, Ponnusamy Ponmurugan, Sengottaiyan Eashwari Jeeva, Kolandasamy Manjukarunambika, Vishwanathan Elango, Kolandaivel Hemalatha, Jyoti Prasad Kakati, Rajamanickam Mohanraj, Somasundaram Prathap
Tea leaves have economic importance in preparation of the popular beverage of the world "tea". Bird's eye spot disease of tea leaves creates significant revenue loss in tea trade of many tea plant cultivating countries. Management of this disease by silver (AgNps) and copper (CuNps) nanoparticles that are biosynthesised by efficient antagonists was studied. The biocontrol agents like Pseudomonas fluorescens, Trichoderma atroviride and Streptomyces sannanensis were evaluated for nanoparticle synthesis against Cercospora theae isolates namely KC10, MC24 and VC38...
December 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/29155174/ethnopharmacology-phytochemistry-and-pharmacology-of-cornus-officinalis-sieb-et-zucc
#16
REVIEW
Jun Huang, Yiwei Zhang, Lin Dong, Qinghan Gao, Lei Yin, Hongfeng Quan, Rong Chen, Xueyan Fu, Dingbo Lin
ETHNOPHARMACOLOGICAL RELEVANCE: Cornus officinalis (Cornaceae), known in Chinese as "Shanzhuyu," is a frequently used traditional Chinese medicine. It tastes sour and is astringent and slightly warm in nature. Its fruits have long been used to treat kidney deficiency, high blood pressure, waist and knee pain, dizziness, tinnitus, impotence, spermatorrhea, menorrhagia, and other diseases in China. The main distribution areas are Shanxi and Gansu. AIM OF THE STUDY: This review focused on the ethnopharmacological uses of the herb...
November 16, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29154802/microrna-profiling-in-mda-mb-231-human-breast-cancer-cell-exposed-to-the-phaleria-macrocarpa-boerl-fruit-ethyl-acetate-fraction-pmeaf-through-iilumina-hi-seq-technologies-and-various-in-silico-bioinformatics-tools
#17
Nowroji Kavitha, Soundararajan Vijayarathna, Shanmugapriya, Chern Ein Oon, Yeng Chen, Jagat R Kanwar, Vasu Punj, Sreenivasan Sasidharan
ETHNOPHARMACOLOGICAL RELEVANCE: Phaleria macrocarpa (Scheff) Boerl, is a famous traditional medicinal plant which exhibited cytotoxicity against various cancerous cells. Traditionally, P. macrocarpa has been used to control cancer, impotency, hemorrhoids, diabetes mellitus, allergies, liver and heart disease, kidney disorders, blood diseases, acne, stroke, migraine, and various skin diseases. AIM OF THE STUDY: Recent studies have demonstrated a potent anticancer potential of P...
November 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29154205/identification-and-temporal-decrease-of-137-cs-and-134-cs-in-groundwater-in-minami-soma-city-following-the-accident-at-the-fukushima-dai-ichi-nuclear-power-plant
#18
Kiyoshi Shizuma, Yoko Fujikawa, Momo Kurihara, Yushi Sakurai
The Fukushima Dai-ichi Nuclear Power Plant (FDNPP) accident on March 11, 2011, caused severe radioactive contamination in Fukushima Prefecture. In order to clarify the safety of drinking water, we have conducted radiocesium monitoring of public tap water and groundwater in Minami-Soma City, which is 10-40 km north of the nuclear power plant. The source of tap water for Minami-Soma City is groundwater, which is treated by rapid filtration before distribution in two of the three treatment plants. The tap water was collected from six stations during 2012-2016 and groundwater was collected from 11 stations with wells between 5 and 100 m deep during 2014-2016...
November 16, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29154192/resveratrol-attenuates-testicular-apoptosis-in-type-1-diabetic-mice-role-of-akt-mediated-nrf2-activation-and-p62-dependent-keap1-degradation
#19
Yuguang Zhao, Wenjing Song, Zhenyu Wang, Zongqiang Wang, Xing Jin, Jiancheng Xu, Ling Bai, Yuying Li, Jiuwei Cui, Lu Cai
Infertility is a common complication in diabetic men, mainly due to the loss of germ cells by apoptotic cell death. However, effective and safe approaches to prevent diabetic induction of testicular apoptosis for diabetic patients have not been available. Resveratrol (RSV), a group of compounds called polyphenols from plants, has been indicated its promising used clinically for cancers and cardiovascular diseases. Therefore, the present study aimed determining whether RSV attenuates type 1 diabetes (T1D)-induced testicular apoptotic cell death in a mouse model...
November 8, 2017: Redox Biology
https://www.readbyqxmd.com/read/29154152/a-mathematical-model-to-plan-for-long-term-effects-of-water-conservation-choices-on-dry-weather-wastewater-flows-and-concentrations
#20
Lauren M Cook, Constantine Samaras, Jeanne M VanBriesen
In many cities, sewer systems are experiencing conditions that are significantly different from those for which they were designed. Factors such as water conservation efforts, changes in population, and efforts to reduce infiltration are altering the quantity and quality of sewage. These changes may affect the ability of sewers to maintain self-cleansing velocities, which are crucial to avoiding solids settling and corrosion issues. Further, such changes may alter the timeline for expected wastewater plant expansion...
November 15, 2017: Journal of Environmental Management
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