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https://www.readbyqxmd.com/read/29652200/bursera-copallifera-extracts-have-cytotoxic-and-migration-inhibitory-effects-in-breast-cancer-cell-lines
#1
Fabiola Domínguez, Paola Maycotte, Adilene Acosta-Casique, Sofía Rodríguez-Rodríguez, Diego A Moreno, Federico Ferreres, Juan Carlos Flores-Alonso, María Guadalupe Delgado-López, Martín Pérez-Santos, Maricruz Anaya-Ruiz
Plants from the Bursera genus are widely distributed in the tropical dry forests of Mexico. In traditional medicine, extracts from different species of Bursera have been used for a wide range of biological activities, including the treatment of cancer-related symptoms. Compounds present in the Bursera genus include lignans, flavonoids, steroids, short-chain aliphatic alkanes, acetates, alcohols, ketones, and terpenoids. In some instances, secondary metabolites of these classes of compounds may induce cytotoxicity, and therefore we sought to investigate the effects of B...
April 1, 2018: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29651878/in-vivo-hypoglycemic-effect-of-kigelia-africana-lam-studies-with-alloxan-induced-diabetic-mice
#2
Stephen M Njogu, Wycliffe M Arika, Alex K Machocho, Joseph J N Ngeranwa, Eliud N M Njagi
The claims by the traditional herbal medicine practitioners that Kigelia africana has bioactivity against several diseases, including diabetes mellitus, were investigated in this study. Type I diabetes mellitus was induced in mice by intraperitoneal administration of alloxan monohydrate followed by treatment with the therapeutic doses of the aqueous and ethyl acetate leaf extract of K africana to the experimentally diabetic mice. The treatment effects were compared with the normal control, diabetic control, and diabetic control rats treated with a standard antidiabetic drugs (insulin administered intraperitoneally at 1 IU/kg body weight in 0...
January 2018: Journal of evidence-based integrative medicine
https://www.readbyqxmd.com/read/29649979/ginseng-genome-database-an-open-access-platform-for-genomics-of-panax-ginseng
#3
Murukarthick Jayakodi, Beom-Soon Choi, Sang-Choon Lee, Nam-Hoon Kim, Jee Young Park, Woojong Jang, Meiyappan Lakshmanan, Shobhana V G Mohan, Dong-Yup Lee, Tae-Jin Yang
BACKGROUND: The ginseng (Panax ginseng C.A. Meyer) is a perennial herbaceous plant that has been used in traditional oriental medicine for thousands of years. Ginsenosides, which have significant pharmacological effects on human health, are the foremost bioactive constituents in this plant. Having realized the importance of this plant to humans, an integrated omics resource becomes indispensable to facilitate genomic research, molecular breeding and pharmacological study of this herb...
April 12, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/29649320/strychnos-pseudoquina-modulates-the-morphological-reorganization-of-the-scar-tissue-of-second-intention-cutaneous-wounds-in-rats
#4
Mariáurea Matias Sarandy, Lyvia Lopes Miranda, Luciana Schulthais Altoé, Rômulo Dias Novaes, Virgínia Vinha Zanuncio, João Paulo Viana Leite, Reggiani Vilela Gonçalves
Natural substances are used in folk medicines to treat injuries. Strychnos pseudoquina has scarring, antipyretic, and antimalarial actions. The present study aimed to analyze the effect of S. pseudoquina on cutaneous wound healing in rats. The S. pseudoquina extract was submitted to phytochemical prospection. The levels of flavonoids and total phenolic compounds in the extract were 50.7 mg/g and 2.59 mg/g, respectively. Thirty Wistar rats were individualized in cages with food and water ad libitum (registration no...
2018: PloS One
https://www.readbyqxmd.com/read/29649130/separation-identification-and-antidiabetic-activity-of-catechin-isolated-from-arbutus-unedo-l-plant-roots
#5
Hanae Naceiri Mrabti, Nidal Jaradat, Ismail Fichtali, Wessal Ouedrhiri, Shehdeh Jodeh, Samar Ayesh, Yahia Cherrah, My El Abbes Faouzi
Phytopharmaceuticals play an essential role in medicine, since the need to investigate highly effective and safe drugs for the treatment of diabetes mellitus disease remains a significant challenge for modern medicine. Arbutus unedo L. root has various therapeutic properties, and has been used widely in the traditional medicine as an antidiabetic agent. The current study aimed to isolate the pharmacologically active compound from A. unedo roots using accelerated solvent extraction technology, to determine its chemical structure using different instrumental analytical methods, and also to evaluate the α-glucosidase inhibitory activity...
April 12, 2018: Plants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29648666/the-basic-helix-loop-helix-transcription-factor-gubhlh3-positively-regulates-soyasaponin-biosynthetic-genes-in-glycyrrhiza-uralensis
#6
Keita Tamura, Koki Yoshida, Yasuko Hiraoka, Daiki Sakaguchi, Ayaka Chikugo, Keiichi Mochida, Mareshige Kojoma, Nobutaka Mitsuda, Kazuki Saito, Toshiya Muranaka, Hikaru Seki
Glycyrrhiza uralensis (licorice) is a widely used medicinal plant belonging to the Fabaceae. Its main active component, glycyrrhizin, is an oleanane-type triterpenoid saponin widely used as a medicine and as a natural sweetener. Licorice also produces other triterpenoids, including soyasaponins. Recent studies have revealed various oxidosqualene cyclases and cytochrome P450 monooxygenases (P450s) required for the biosynthesis of triterpenoids in licorice. Of these enzymes, β-amyrin synthase (bAS) and β-amyrin C-24 hydroxylase (CYP93E3) are involved in the biosynthesis of soyasapogenol B (an aglycone of soyasaponins) from 2,3-oxidosqualene...
April 1, 2018: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29648503/brazilian-medicinal-plants-with-corroborated-anti-inflammatory-activities-a-review
#7
Victor Pena Ribeiro, Caroline Arruda, Mohamed Abd El-Salam, Jairo Kenupp Bastos
CONTEXT: Inflammatory disorders are common in modern life, and medicinal plants provide an interesting source for new compounds bearing anti-inflammatory properties. In this regard, Brazilian medicinal plants are considered to be a promising supply of such compounds due to their great biodiversity. OBJECTIVES: To undertake a review on Brazilian medicinal plants with corroborated anti-inflammatory activities by selecting data from the literature reporting the efficacy of plants used in folk medicine as anti-inflammatory, including the mechanisms of action of their extracts and isolated compounds...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29644597/plant-borne-compounds-and-nanoparticles-challenges-for-medicine-parasitology-and-entomology
#8
EDITORIAL
Giovanni Benelli
No abstract text is available yet for this article.
April 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29644026/synergistic-apoptotic-effects-of-tocotrienol-isomers-and-acalypha-wilkesiana-on-a549-and-u87mg-cancer-cells
#9
Ibrahim Babangida Abubakar, Su-Wen Lim, Hwei-San Loh
Recent studies suggested that combined treatment approaches can be used to improve anticancer potency and circumvent the limitations of high-dose tocotrienols administration. Acalypha wilkesiana is a medicinal plant that has been used as an adjunct treatment for cancers in traditional medicine. Herein, the effects of single and combined treatments of β-, γ- and δ-tocotrienols and ethyl acetate extract (9EA) of Acalypha wilkesiana on lung (A549) and brain (U87MG) cancer cells were investigated. γ- and δ-tocotrienols exhibited higher potent antiproliferative effects against A549 (12...
March 2018: Tropical Life Sciences Research
https://www.readbyqxmd.com/read/29643516/-preliminary-study-of-robot-assisted-ankle-rehabilitation-for-children-with-cerebral-palsy
#10
R L Wang, Z H Zhou, Y C Xi, Q N Wang, N H Wang, Z Huang
OBJECTIVE: To propose a kind of robotic ankle-foot rehabilitation system for children with cerebral palsy and to preliminarily verify its feasibility in clinical application. METHODS: A robot assisted ankle-foot rehabilitation system was specially designed and developed for children with cerebral palsy and a preliminary clinical study was conducted in Department of Rehabilitation Medicine, Peking University First Hospital. Modified Tardieu Scale and joint biomechanical properties (ankle plantar flexion resistance torque under different ankle dorsiflexion angles) were measured to analyze the muscle tone and soft tissue compliance of the ankle plantar flexors pre- and post-robotic training intervention...
April 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29642867/antiproliferative-activities-and-phenolic-acid-content-of-water-and-ethanolic-extracts-of-the-powdered-formula-of-houttuynia-cordata-thunb-fermented-broth-and-phyllanthus-emblica-linn-fruit
#11
Piyawan Kumnerdkhonkaen, Somprasong Saenglee, Md Ali Asgar, Gulsiri Senawong, Kanoknan Khongsukwiwat, Thanaset Senawong
BACKGROUND: Houttuynia cordata Thunb. and Phyllanthus emblica Linn. are native plants with medicinal and nutritive significance in Asia. The present study was aimed at evaluating antiproliferative effects on human cancer cell lines and identifying the phenolic acid composition of water and ethanolic extracts of the powdered formula of H. cordata fermented broth and P. emblica fruit. METHODS: Anticancer activity of the extracts was evaluated against HeLa, HT29, HCT116, MCF7 and Jurkat cells using an MTT assay and flow cytometric analysis of apoptosis induction and cell cycle arrest...
April 11, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29642545/chloroplast-genome-of-the-folk-medicine-and-vegetable-plant-talinum-paniculatum-jacq-gaertn-gene-organization-comparative-and-phylogenetic-analysis
#12
Xia Liu, Yuan Li, Hongyuan Yang, Boyang Zhou
The complete chloroplast (cp) genome of Talinum paniculatum (Caryophyllale), a source of pharmaceutical efficacy similar to ginseng, and a widely distributed and planted edible vegetable, were sequenced and analyzed. The cp genome size of T. paniculatum is 156,929 bp, with a pair of inverted repeats (IRs) of 25,751 bp separated by a large single copy (LSC) region of 86,898 bp and a small single copy (SSC) region of 18,529 bp. The genome contains 83 protein-coding genes, 37 transfer RNA (tRNA) genes, eight ribosomal RNA (rRNA) genes and four pseudogenes...
April 9, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29629657/advances-in-the-use-of-anti-inflammatory-agents-to-manage-chemotherapy-induced-oral-and-gastrointestinal-mucositis
#13
Vaishnavi J Mahendran, Andrea M Stringer, Susan J Semple, Yunmei Song, Sanjay Garg
Mucositis is a side effect associated with the use of chemotherapy, and has a significant impact on the quality of life. Mucositis, by definition, refers to the inflammation of the mucosa and occurs throughout the alimentary tract from the mouth to anus. Nuclear factor kappa B (NFκB) encompasses a family of transcription factors, which upregulate pro-inflammatory cytokines. Both are recognized as key targets in developing therapeutic interventions for chemotherapy-induced mucositis, and cyclooxygenase (COX)-2 inhibition may also be beneficial in reducing the severity and duration...
April 8, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29629341/role-of-curcumin-in-disease-prevention-and-treatment
#14
REVIEW
Arshad Husain Rahmani, Mohammed A Alsahli, Salah M Aly, Masood A Khan, Yousef H Aldebasi
Treatment based on traditional medicine is very popular in developing world due to inexpensive properties. Nowadays, several types of preparations based on medicinal plants at different dose have been extensively recognized in the diseases prevention and treatment. In this vista, latest findings support the effect of Curcuma longa and its chief constituents curcumin in a broad range of diseases cure via modulation of physiological and biochemical process. In addition, various studies based on animal mode and clinical trials showed that curcumin does not cause any adverse complications on liver and kidney function and it is safe at high dose...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29629064/plantago-major-in-traditional-persian-medicine-and-modern-phytotherapy-a-narrative-review
#15
REVIEW
Younes Najafian, Shokouh Sadat Hamedi, Masoumeh Kaboli Farshchi, Zohre Feyzabadi
Plantago major has been used widely since ancient times, to manage a wide range of diseases including constipation, coughs and wounds. The aim of this study is to review the traditional application, botanical characterization, pharmacological activities, phytochemistry effects and toxicity of Plantago major. In this review study, medicinal properties of Plantago major are collected from credible pharmacopeias, textbooks of traditional Persian medicine (TPM) belonging to the 10-18th century AD, such as "The Canon of Medicine", "Makhzan-Al- Advia" and so on...
February 2018: Electronic Physician
https://www.readbyqxmd.com/read/29627297/neuropharmacological-effects-of-essential-oil-from-the-leaves-of-croton-conduplicatus-kunth-and-possible-mechanisms-of-action-involved
#16
Raimundo Gonçalves de Oliveira Júnior, Christiane Adrielly Alves Ferraz, Juliane Cabral Silva, Roxana Braga de Andrade Teles, Mariana Gama E Silva, Tâmara Coimbra Diniz, Uiliane Soares Dos Santos, Ana Valéria Vieira de Souza, Carlos Eduardo Pereira Nunes, Marcos José Salvador, Vitor Prates Lorenzo, Lucindo José Quintans Junior, Jackson Roberto Guedes da Silva Almeida
ETHNOPHARMACOLOGICAL RELEVANCE: Croton conduplicatus Kunth (Euphorbiaceae) is a Brazilian aromatic medicinal plant, widely known as "quebra-faca". In folk medicine, its leaves and stem-barks are used as a natural analgesic for the treatment of headaches. AIM OF THE STUDY: In this study, we describe for the first time the neuropharmacological potential of the essential oil obtained from the leaves of Croton conduplicatus (EO) in experimental models of pain, anxiety and insomnia...
April 5, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29626672/the-suppressive-effects-of-vochysia-divergens-aqueous-leaf-extract-and-its-5-methoxyflavone-on-murine-macrophages-and-lymphocytes
#17
Maria Fernanda Paresqui Corrêa, Thatiana Lopes Biá Ventura, Michelle Frazão Muzitano, Elaine Dos Anjos da Cruz, Maria Camilla Bergonzi, Anna Rita Bilia, Bartira Rossi-Bergmann, Sônia Soares Costa
ETHNOPHARMACOLOGICAL RELEVANCE: Leaf infusion from the tree Vochysia divergens Pohl (Vochysiaceae), known as "cambará", is used in Brazilian popular medicine against respiratory infections and asthma. AIM OF THE STUDY: To evaluate the health-beneficial effects related to the ethnomedicinal uses of V. divergens (Vd), a biomonitored fractionation of an aqueous leaf extract was carried out. MATERIALS AND METHODS: Leaves were extracted by decoction with distilled water, and the extract fractionated by a combination of separation techniques including precipitation, organic partition and chromatography...
April 4, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29626581/the-use-of-plants-containing-genotoxic-carcinogens-as-foods-and-medicine
#18
Gerhard Prinsloo, Noluyolo Nogemane, Renee Street
In many developing countries, populations rely on traditional medicine for primary health care, which have infiltrated commercial markets globally as natural remedies are generally regarded as safe. Traditional and natural remedies are adapted and expanded in commercial products and product ranges to provide alternatives for various diseases and illnesses. These products resemble very little of the traditional use and application and adverse effects are observed in several cases. Some of the herbs and botanical formulations therefore, are not as safe as are commonly contemplated...
April 4, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29624949/medicinal-plants-used-during-antenatal-care-by-pregnant-women-in-eastern-uganda
#19
Patricia A Nalumansi, Maud Kamatenesi-Mugisha, Godwin Anywar
Plants are commonly used during the antenatal stage in pregnancy to manage different ailments in Africa. In Uganda, both medicinal and food plants are used to handle common pregnancy related conditions. An ethnobotanical survey was conducted in Iganga district, eastern Uganda. Seven traditional birth attendants (TBA) and 46 mothers were interviewed. Data was collected using structured questionnaires and household interviews. The TBAs were identified using snowball sampling. A total of 33 plant species, belonging to 23 families were documented...
December 2017: African Journal of Reproductive Health
https://www.readbyqxmd.com/read/29624609/integrated-approach-for-identifying-and-evaluating-the-quality-of-marsdenia-tenacissima-in-the-medicine-market
#20
Ning Yu, Yu-Long Wei, Yue Zhu, Ning Zhu, Yan-Li Wang, Hai-Ping Zhang, Ai-Dong Sun
The accurate identification and quality evaluation of herbal medical plants is highly necessary to ensure their safety and efficacy. In present study, a new strategy combining DNA barcoding techniques with thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC) was proposed to facilitate the identification and quality control of M. tenacissima. In present work, the internal transcribed spacer 2 (ITS2) barcode was successfully used to identify 58 M. tenacissima samples and its adulterants...
2018: PloS One
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