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https://www.readbyqxmd.com/read/29933016/potential-therapeutic-applications-of-the-genus-annona-local-and-traditional-uses-and-pharmacology
#1
REVIEW
A M Quílez, M A Fernández-Arche, M D García-Giménez, R De la Puerta
ETHNO-PHARMACOLOGICAL RELEVANCE: Annona species (Annonaceae) have long been used as traditional herbal medicines by native peoples in tropical areas. In different countries they are used against a large variety of illnesses, such as parasitic and infectious diseases, cancer, diabetes, peptic ulcers, and mental disorders. AIM OF THE STUDY: This review aims to achieve a comprehensive understanding of the research conducted so far on the local and traditional uses, pharmacological activities, mechanism of actions of active compounds, toxicity, and possible interactions with other drugs of the Annona species...
June 19, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29933011/the-rise-of-medicalization-of-plants-in-brazil-a-temporal-perspective-on-vernacular-names
#2
Bruno V L Siqueira, Cássia M Sakuragui, Bruno E Soares, Danilo R de Oliveira
ETHNOPHARMACOLOGICAL RELEVANCE: Brazilian plant species used in folk medicine have acquired several popular names related to commercial medicines in recent decades. This fact has directly effect to the medicalization process. AIM OF THE STUDY: Evaluate the rise of medicalized popular names of medicinal plants in Brazil. MATERIALS AND METHODS: Medicalized popular names of medicinal plants were recorded from 273 ethnobotanical articles in eleven scientific journals published between 1980 and 2017...
June 19, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29932194/quality-assessment-of-penthorum-chinense-pursh-through-multicomponent-qualification-and-fingerprint-chemometric-and-antihepatocarcinoma-analyses
#3
Zong-Liang Sun, Yu-Zhen Zhang, Feng Zhang, Jia-Wei Zhang, Guo-Can Zheng, Ling Tan, Chong-Zhi Wang, Lian-Di Zhou, Qi-Hui Zhang, Chun-Su Yuan
An efficient method combined with fingerprint and chemometric analyses was developed to evaluate the quality of the traditional Chinese medicine plant Penthorum chinense Pursh. Nine samples were collected from different regions during different harvest periods, and 17 components in the form of extracts were simultaneously examined to assess quality by using high-performance liquid chromatography. The hepatoprotective effects of components were investigated by assessing the inhibition of SMMC-7721 cell growth...
June 22, 2018: Food & Function
https://www.readbyqxmd.com/read/29932034/clinical-use-of-toxic-proteins-and-peptides-from-tian-hua-fen-and-scorpion-venom
#4
Chen Ling, Yuanhui Zhang, Jun Li, Wenli Chen, Changquan Ling
Traditional Chinese Medicine (TCM) has been practiced in China for thousands of years. As a complementary and alternative treatment, herbal medicines that are frequently used in the TCM are the most accepted in the Western world. However, animal materials, which are equally important in the TCM practice, are not well-known in other countries. On the other hand, the Chinese doctors had documented the toxic profiles of hundreds of animals and plants thousand years ago. Furthermore, they saw the potential benefits of these materials and used their toxic properties to treat a wide variety of diseases, such as heavy pain and cancer...
June 21, 2018: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/29929299/occurrence-and-ecotoxicological-assessment-of-pharmaceuticals-is-there-a-risk-for-the-mediterranean-aquatic-environment
#5
REVIEW
Fanny Desbiolles, Laure Malleret, Christophe Tiliacos, Pascal Wong-Wah-Chung, Isabelle Laffont-Schwob
Due to their pseudo-persistence and their biological activity, pharmaceuticals are emerging contaminants of major concern for the environment. The aim of this review is to provide an updated inventory of the contamination of aquatic environments by 43 drugs representing different classes of pharmaceuticals, such as antibiotics, anti-inflammatory drugs, anti-depressants, sex hormones, lipid regulators and beta-blockers. The data collected is focused on contamination levels reported in marine coastal waters and in waste and river waters flowing into the Mediterranean Sea...
October 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29929208/dna-barcoding-for-the-identification-of-phyllanthus-taxa-used-medicinally-in-brazil
#6
Peter W Inglis, Lorena R Mata, Marcos José da Silva, Roberto F Vieira, Rosa de B N Alves, Dijalma B Silva, Vânia C R Azevedo
Plants of the genus Phyllanthus, principally Phyllanthus amarus, Phyllanthus urinaria, Phyllanthus niruri , and Phyllanthus tenellus, are used in Brazilian folk medicine to treat kidney stones as well as other ailments, where the latter two species are listed in the Brazilian Pharmacopeia as quebra-pedra ( stone-breaker ). However, only P. niruri has been shown to be effective in a clinical setting. Nuclear ribosomal internal transcribed spacer (ITS1 - 5.8S rRNA-ITS2), internal transcribed spacer 2, and chloroplasts rbc L, mat K, psb A- trn H, trn L, and trn L- trn F were screened for their potential as DNA barcodes for the identification of 48 Phyllanthus taxa in Brazilian medicinal plant germplasm banks and in "living pharmacies"...
June 21, 2018: Planta Medica
https://www.readbyqxmd.com/read/29928326/miltirone-induced-apoptosis-in-cisplatin-resistant-lung-cancer-cells-through-upregulation-of-p53-signaling-pathways
#7
Zhongcheng Zhu
The active ingredients of natural plants are important sources of antitumor agents. Miltirone is a major effective ingredient in traditional Chinese medicine and it is considered to have anti-infection and immunosuppressive activities. Clinically, it is often used for the treatment of arthritis and immune diseases. The effect of miltirone on cisplatin-resistant lung cancer cells has not been investigated to date. The present study aimed to examine the anticancer effect of miltirone in cisplatin-resistant lung cancer cells...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928122/the-effect-of-evening-primrose-oil-on-fatigue-and-quality-of-life-in-patients-with-multiple-sclerosis
#8
Nastaran Majdinasab, Foroogh Namjoyan, Mohsen Taghizadeh, Hamid Saki
Background: Multiple sclerosis (MS) is a chronic progressive and inflammatory disease of the central nervous system that is characterized by demyelination in the central nervous system. In regard to the prevalence of diseases and enormous costs imposed on society and the health system, finding a way to stop the progression of the disease using drugs with fewer side effects seems a serious sanitation issue to the health of the international community. This study aimed to evaluate the effect of evening primrose oil (EPO) on fatigue and quality of life in patients with MS...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29925223/therapeutic-potential-of-the-rhizomes-of-anemarrhena-asphodeloides-and-timosaponin-a-iii-in-an-animal-model-of-lipopolysaccharide-induced-lung-inflammation
#9
Byung Kyu Park, Kyung Su So, Hye Jung Ko, Hyun Joong Kim, Ki Sun Kwon, Yong Soo Kwon, Kun Ho Son, Soon Youl Kwon, Hyun Pyo Kim
Investigations into the development of new therapeutic agents for lung inflammatory disorders have led to the discovery of plant-based alternatives. The rhizomes of Anemarrhena asphodeloides have a long history of use against lung inflammatory disorders in traditional herbal medicine. However, the therapeutic potential of this plant material in animal models of lung inflammation has yet to be evaluated. In the present study, we prepared the alcoholic extract and derived the saponin-enriched fraction from the rhizomes of A...
June 21, 2018: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/29925102/safety-and-toxicology-of-magnolol-and-honokiol
#10
Andrea Sarrica, Natalja Kirika, Margherita Romeo, Mario Salmona, Luisa Diomede
Magnolia officinalis and Magnolia obovata bark extracts have been used for thousands of years in Chinese and Japanese traditional medicines and are still widely employed as herbal preparations for their sedative, antioxidant, anti-inflammatory, antibiotic, and antispastic effects. Neolignans, particularly magnolol and honokiol, are the main substances responsible for the beneficial properties of the magnolia bark extract (MBE). The content of magnolol and honokiol in MBE depends on different factors, including the Magnolia plant species, the area of origin, the part of the plant employed, and the method used to prepare the extract...
June 20, 2018: Planta Medica
https://www.readbyqxmd.com/read/29925101/the-difference-between-white-and-red-ginseng-variations-in-ginsenosides-and-immunomodulation
#11
Min He, Xin Huang, Shuying Liu, Chunsheng Guo, Yufei Xie, Annemarie H Meijer, Mei Wang
Ginseng Radix ( Panax ginseng ) is one of the most commonly used herbs worldwide for the treatment of inflammation-related diseases among others, supported by ancient historical records. Throughout this long history, the large-scale cultivation of ginseng created an increasing demand for long-term storage of the harvested plant material, accelerating the development of post-harvesting procedures. Dried white ginseng and processed (steamed) red ginseng are the products of the two most common traditional post-harvest processes...
June 20, 2018: Planta Medica
https://www.readbyqxmd.com/read/29923222/effects-of-curcumin-on-nf-%C3%AE%C2%BAb-ap-1-and-wnt-%C3%AE-catenin-signaling-pathway-in-hepatitis-b-virus-infection
#12
AmirReza Hesari, Faezeh Ghasemi, Reza Salarinia, Hamed Biglari, Agheel Tabar Molla Hassan, Vali Abdoli, Hamed Mirzaei
Curcumin is a yellow-orange powder derived from the Curcuma longa plant. Curcumin has been used extensively in traditional medicine for centuries. This component is non-toxic and shown different therapeutic properties such as anti-inflammatory, anti-cancer, antiviral, anti-bacterial, anti-fungal, anti-parasites, and anti-oxidant. Hepatitis B virus (HBV) is a small DNA member of the genus Orthohepadnavirus (Hepadnaviridae family) which is a highly contagious blood-borne viral pathogen. HBV infection is a major public health problem with 2 billion people infected throughout the world and 350 million suffering from chronic HBV infection...
June 19, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29922588/toxic-effects-of-lambda-cyhalothrin-on-the-rat-thyroid-involvement-of-oxidative-stress-and-ameliorative-effect-of-ginger-extract
#13
Wael M Al-Amoudi
Lambda-cyhalothrin (LCT) is a synthetic pyrethroid that is widely used to control insecticide. Ginger is a traditional plant that is widely used as a spice or folk medicine. This study evaluates the antioxidant effect of ginger extract on thyroid toxicity induced by LCT in albino rats. Adult Rats were divided into 4 experimental groups: Group 1: control, Group 2: oral ginger treatment (24 mg/ml, 3 days/week for 4 weeks), Group 3: oral LCT treatment (1/100 LD50 , 3 days/week for 4 weeks), Group 4: oral LCT and ginger mixture treatment...
2018: Toxicology Reports
https://www.readbyqxmd.com/read/29920357/in-vivo-wound-healing-activity-of-euphorbia-characias-subsp-wulfenii-isolation-and-quantification-of-quercetin-glycosides-as-bioactive-compounds
#14
Serkan Özbilgin, Özlem Bahadır Acıkara, Esra Küpeli Akkol, Ipek Süntar, Hikmet Keleş, Gülçin Saltan İşcan
ETHNOPHARMACOLOGICAL RELEVANCE: The latex and the aerial parts of Euphorbia characias L. (Euphorbiaceae) have been used as medicinal plant to treat wounds and warts in traditional medicine. AIM OF THE STUDY: The effect of the plant extract was tested in vivo and in vitro with experimental models to find scientific evidence for traditional use in wound healing. Potentially active wound-healer compounds were isolated from the active fraction using fractionation procedures under the guidance of biological assay and the possible role of the compounds in the wound healing process was also determined...
June 16, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29917280/protective-effects-of-cinnamon-bark-extract-against-ischemia-reperfusion-injury-and-arrhythmias-in-rat
#15
Mehrnoosh Sedighi, Afshin Nazari, Mahdieh Faghihi, Mahmoud Rafieian-Kopaei, Arash Karimi, Maryam Moghimian, Seyyed Ali Mozaffarpur, Marzieh Rashidipour, Mehrdad Namdari, Mostafa Cheraghi, Bahram Rasoulian
Cinnamomum zeylanicum (cinnamon) is a plant with potent antioxidant activity and has been used in traditional medicine for improvement of heart function. The effects of cinnamon bark ethanolic extract were investigated against ischemia-induced arrhythmias and heart injury in an in vivo rat model of regional heart ischemia. The extract was also standardized, and its antioxidant activity was evaluated. Adult male Sprague-Dawley rats were subjected to 30 min of ischemia by occlusion of the left anterior descending coronary artery followed by 5 days of reperfusion...
June 19, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29914391/in-vitro-mineral-nutrition-of-curcuma-longa-l-affects-production-of-volatile-compounds-in-rhizomes-after-transfer-to-the-greenhouse
#16
Rabia F El-Hawaz, Mary H Grace, Alan Janbey, Mary Ann Lila, Jeffrey W Adelberg
BACKGROUND: Turmeric is a rich source of bioactive compounds useful in both medicine and cuisine. Mineral concentrations effects (PO4 3- , Ca2+ , Mg2+ , and KNO3 ) were tested during in vitro rhizome development on the ex vitro content of volatile constituents in rhizomes after 6 months in the greenhouse. A response surface method (D-optimal criteria) was repeated in both high and low-input fertilizer treatments. Control plants were grown on Murashige and Skoog (MS) medium, acclimatized in the greenhouse and grown in the field...
June 18, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/29914183/graviola-annona-muricata-exerts-anti-proliferative-anti-clonogenic-and-pro-apoptotic-effects-in-human-non-melanoma-skin-cancer-uw-bcc1-and-a431-cells-in-vitro-involvement-of-hedgehog-signaling
#17
Jean Christopher Chamcheu, Islam Rady, Roxane-Cherille N Chamcheu, Abu Bakar Siddique, Melissa B Bloch, Sergette Banang Mbeumi, Abiola S Babatunde, Mohammad B Uddin, Felicite K Noubissi, Peter W Jurutka, Yong-Yu Liu, Vladimir S Spiegelman, G Kerr Whitfield, Khalid A El Sayed
Non-melanoma skin cancers (NMSCs) are the leading cause of skin cancer-related morbidity and mortality. Effective strategies are needed to control NMSC occurrence and progression. Non-toxic, plant-derived extracts have been shown to exert multiple anti-cancer effects. Graviola ( Annona muricata ), a tropical fruit-bearing plant, has been used in traditional medicine against multiple human diseases including cancer. The current study investigated the effects of graviola leaf and stem extract (GLSE) and its solvent-extracted fractions on two human NMSC cell lines, UW-BCC1 and A431...
June 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29913711/some-practical-treatment-methods-of-dealing-with-pain-disabilities-in-rural-ghana
#18
Desmond Ayim-Aboagye, T Gordh
Background and aims The investigation was conducted among six practitioners and twenty-two patients in rural Ghana, where both practitioners and patients, were asked to unveil effective methods of treating pain and pain disabilities. Methods The investigation utilised strictly observational methods in acquiring data from two communities. Both patients and practitioners were later interviewed in a manner that elicited certain information needed to provide accurate understanding concerning these treatments methods they give to patients...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913232/genotoxic-alkenylbenzene-flavourings-a-contribution-to-risk-assessment
#19
Célia Martins, José Rueff, António S Rodrigues
Alkenylbenzenes, such as estragole, myristicin and eugenol, are present is several flavourings, functional foods, plant food supplements (PFS) and in complementary and alternative medicines (CAM) including herbal medicines. The increase in consumption in functional foods observed worldwide requires a strict analysis of the scientific validity of their benefits and risk-benefit ratio associated with their intake. Some instances of acute toxicity have been reported associated with the use of herbal medicines and PFS, in particular because quality control is poor, and this poses a risk especially in internet marketed products...
June 15, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29912156/vasodilator-activity-of-compounds-isolated-from-plants-used-in-mexican-traditional-medicine
#20
Francisco J Luna-Vázquez, César Ibarra-Alvarado, María Del Rayo Camacho-Corona, Alejandra Rojas-Molina, J Isela Rojas-Molina, Abraham García, Moustapha Bah
Arterial hypertension is one of the main risk factors in the development of cardiovascular diseases. Therefore, it is important to look for new drugs to treat hypertension. In this study, we carried out the screening of 19 compounds (triterpenes, diterpenes, sesquiterpenes, lignans, and flavonoids) isolated from 10 plants used in Mexican traditional medicine to determine whether they elicited vascular smooth muscle relaxation and, therefore, could represent novel anti-hypertension drug candidates. The vasorelaxant activity of these compounds was evaluated on the isolated rat aorta assay and the results obtained from this evaluation showed that three compounds induced a significant vasodilatory effect: meso -dihydroguaiaretic acid [half maximal effective concentration (EC50 ), 49...
June 18, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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