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https://www.readbyqxmd.com/read/28724259/herbal-pre-conditioning-induces-proliferation-and-delays-senescence-in-wharton-s-jelly-mesenchymal-stem-cells
#1
Avinash Sanap, Bhawna Chandravanshi, Tejas Shah, Girish Tillu, Anand Dhanushkodi, Ramesh Bhonde, Kalpana Joshi
BACKGROUND: Mesenchymal Stem Cells (MSCs) are multipotent stem cells which are being explored for various clinical applications. Isolation and in-vitro expansion of MSCs remain important in achieving desired cell number for the therapy. However, in-vitro proliferation of MSCs is often associated with senescence and early onset of apoptosis which limits its therapeutic ability and long term clinical use. Tinospora cordifolia and Withania somnifera are used widely in Ayurveda: the traditional Indian system of medicine and are reported to have rejuvenating and anti-aging potential...
July 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28723661/decreased-risk-of-dementia-in-migraine-patients-with-traditional-chinese-medicine-use-a-population-based-cohort-study
#2
Chun-Ting Liu, Bei-Yu Wu, Yu-Chiang Hung, Lin-Yi Wang, Yan-Yuh Lee, Tsu-Kung Lin, Pao-Yen Lin, Wu-Fu Chen, Jen-Huai Chiang, Sheng-Feng Hsu, Wen-Long Hu
Patients with migraine are reportedly at increased risk of developing dementia. We aimed to investigate the association between traditional Chinese medicine (TCM) use and dementia risk in migraine patients. This longitudinal cohort study used the Taiwanese National Health Insurance Research Database to identify 32,386 diagnosed migraine patients aged 20 years and above who received treatment from 1997 to 2010. To balance comparability between TCM users and non-TCM users, we randomly selected equal numbers from each group, and compared subgroups compiled based on combinations of age, sex, index year, and year of migraine diagnosis...
July 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28723603/ginkgo-biloba-in-the-treatment-of-tinnitus-an-updated-literature-review
#3
REVIEW
Mohammad Reza Mahmoudian-Sani, Morteza Hashemzadeh-Chaleshtori, Majid Asadi-Samani, Qian Yang
INTRODUCTION: Tinnitus is one of the common diseases of the ear that is associated with numerous physical and mental disorders. One of the known mechanisms in the tinnitus area with unknown reason is oxidative events. Based on the prevalence and economic costs and physical- psychological side effects caused by tinnitus and the importance of finding a suitable solution for its prevention and treatment, the need for further studies becomes more obvious in this context. This review article aimed to review studies on the effectiveness of Ginkgo biloba as a medicinal plant on patients with tinnitus...
June 1, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/28721818/eurycoma-longifolia-a-potential-phytomedicine-for-the-treatment-of-cancer-evidence-of-p53-mediated-apoptosis-in-cancerous-cells
#4
Hnin Ei Thu, Zahid Hussain, Isa Naina Mohamed, Ahmad Nazrun Shuid
BACKGROUND: Eurycoma longifolia is a well-documented herbal medicine that has gained widespread recognition due to its versatile pharmacological activities including anticancer, anti-malarial, antimicrobial, antioxidant, aphrodisiac, anti-inflammatory, anxiolytic, anti-diabetic, anti-rheumatism and anti-ulcer. Plethora of in vitro and in vivo studies evidenced their excellent anti-proliferative and anticancer efficacy against various types of human cancers. OBJECTIVE: This review was aimed to critically analyze the therapeutic viability and anticancer efficacy of Eurycoma longifolia in the treatment of cancer and also to propose its molecular and translational mechanism of cytotoxicity against cancerous cells...
July 18, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28721651/in-vitro-anti-inflammatory-and-antioxidant-activities-of-3-5-4-trihydroxy-6-7-methylenedioxyflavone-o-glycosides-and-their-aglycone-from-leaves-of-polygonum-tinctorium-lour
#5
Shota Tokuyama-Nakai, Hideto Kimura, Tomoe Ishihara, Mitsuo Jisaka, Kazushige Yokota
Polygonum tinctorium Lour (indigo plant) has been regarded as a useful medicinal plant for traditional herbal medicine. The polyphenolic fraction of indigo leaves exhibited anti-inflammatory activities as determined by the suppressed synthesis of nitric oxide (NO) in cultured RAW264 macrophage cells. The acid hydrolysate of the fraction showed much more potent effect than the unhydrolyzed one. In sharp contrast, those fractions of indigo stems had almost no effect. 3,5,4'-Trihydroxy-6,7-methylenedioxyflavone (TMF)-O-glycosides and tryptanthrin were detected exclusively in the extracts of the leaves...
July 18, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28720944/evaluation-of-the-chemical-composition-antioxidant-and-anti-inflammatory-activities-of-distillate-and-residue-fractions-of-sweet-basil-essential-oil
#6
Hailong Li, Yanhui Ge, Zhimin Luo, Yulan Zhou, Xuguang Zhang, Junqing Zhang, Qiang Fu
In this study, the chemical composition and antioxidant and anti-inflammatory activities of sweet basil (Ocimum basilicum L. Lamiaceae family) were evaluated. Sweet basil is a food-related plant that is widely used in traditional Chinese medicine. Sweet basil crude oil was processed via molecular distillation and further characterized using gas chromatography-mass spectrometry (GC-MS) to screen for new compounds. The GC-MS analysis identified thirty-eight compounds. The major constituents of the residue fraction were estragole (17...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28720093/solanum-nigrum-unripe-fruit-fraction-attenuates-adriamycin-resistance-by-down-regulating-multi-drug-resistance-protein-mdr-1-through-jak-stat-pathway
#7
Sankar Jagadeeshan, Diana David, S Jisha, S Manjula, S Asha Nair
BACKGROUND: Solanum nigrum, herbal plant that commonly grows in temperate climate zone, has been used as a traditional folk medicine whose ripen fruits were proven to exhibit anti-tumor properties. In traditional Chinese medicine, it has been used for centuries to cure inflammation, edema, mastitis and hepatic cancer and in the Ayurvedic system of traditional medicine in India, S. nigrum is applied against enteric diseases, ulcer, diarrhea and skin diseases. A methanolic glycosidic extract fraction of unripe fruit of S...
July 18, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28719639/oral-administration-of-chinese-herbal-medicine-during-gestation-period-for-preventing-hemolytic-disease-of-the-newborn-due-to-abo-incompatibility-a-systematic-review-of-randomized-controlled-trials
#8
Huijuan Cao, Ruohan Wu, Mei Han, Patrina Ha Yuen Caldwell, Jian-Ping Liu
BACKGROUND: About 85.3% of hemolytic disease of the newborn (HDN) is caused by maternal-fetal ABO blood group incompatibility. However, there is currently no recommended "best" therapy for ABO incompatibility during pregnancy. OBJECTIVES: To systematically assess the safety and effectiveness of oral Chinese herbal medicine (CHM) for preventing HDN due to ABO incompatibility. METHODS: The protocol of this review was registered on the PROSPERO website (No...
2017: PloS One
https://www.readbyqxmd.com/read/28718090/a-large-retroperitoneal-lymphatic-malformation-successfully-treated-with-traditional-japanese-kampo-medicine-in-combination-with-surgery
#9
Toko Shinkai, Kouji Masumoto, Fumiko Chiba, Nao Tanaka
BACKGROUND: Current treatment options for lymphatic malformations (LMs) are multimodal. Recently, the effectiveness of treating LMs with Eppikajyutsuto (TJ-28) has been reported. TJ-28 is a kind of oral herbal medicine classified as the traditional Japanese Kampo medicine. CASE PRESENTATION: A 12-year-old girl was admitted to our hospital for intermittent upper abdominal pain. Radiological examinations revealed a large (9.5 × 5.8 × 10.0 cm) retroperitoneal LM, which was suspected to adhering and stretching both pancreas head and duodenum...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28717105/ephedrine-induced-mitophagy-via-oxidative-stress-in-human-hepatic-stellate-cells
#10
Ah Young Lee, Yoonjeong Jang, Seong-Ho Hong, Seung-Hee Chang, Sungjin Park, Sanghwa Kim, Kyung-Sun Kang, Ji-Eun Kim, Myung-Haing Cho
The herb Ephedra sinica (also known as Chinese ephedra or Ma Huang), used in traditional Chinese medicine, contains alkaloids identical to ephedrine and pseudoephedrine as its principal active constituents. Recent studies have reported that ephedrine has various side effects in the cardiovascular and nervous systems. In addition, herbal Ephedra, a plant containing many pharmacologically active alkaloids, principally ephedrine, has been reported to cause acute hepatitis. Many studies reported clinical cases, however, the cellular mechanism of liver toxicity by ephedrine remains unknown...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28716572/dpph-hplc-ms-assisted-rapid-identification-of-endothelial-protective-substances-from-xiao-ke-an
#11
Zhenzhong Yang, Zhenhao Li, Zheng Li
ETHNOPHARMACOLOGICAL RELEVANCE: Xiao-Ke-An formula (XKA) is a Chinese medicine widely used for treating diabetes and associated complications. Endothelial protection is thought to be one of its therapeutic mechanisms. However, the protective effect of XKA on endothelial cells remains unclear, especially in oxidative injury induced endothelial dysfunction. MATERIALS AND METHODS: A novel strategy to rapidly screen and identify potential endothelial protective substances from XKA was established by combining the 2,2'-diphenyl-1-picrylhydrazyl high performance liquid chromatography coupled with mass spectrometry (DPPH-HPLC-MS) approach with cell-based verification...
July 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28716571/antiviral-effect-of-forsythoside-a-from-forsythia-suspensa-thunb-vahl-fruit-against-influenza-a-virus-through-reduction-of-viral-m1-protein
#12
Anna Hing-Yee Law, Cindy Lai-Hung Yang, Allan Sik-Yin Lau, Godfrey Chi-Fung Chan
ETHNOPHARMACOLOGICAL RELEVANCE: Yinqiaosan is a classical traditional Chinese medicine formula, which has been used to treat respiratory diseases since ancient China. It consists of nine herbs and among them, Forsythia suspensa (Thunb.) Vahl fruit is one of the major herbal components. Despite the long history of Yinqiaosan, the active compounds and the mechanisms of action of this formula remain elusive. AIM OF THE STUDY: The present study aimed to examine the suppressive effect of Yinqiaosan on influenza virus and to identify the active components in the formula targeting influenza...
July 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28714500/exploring-the-immunomodulatory-and-anticancer-properties-of-zerumbone
#13
REVIEW
Md Areeful Haque, Ibrahim Jantan, Laiba Arshad, Syed Nasir Abbas Bukhari
Plant-derived immunomodulators and anti-cancer agents have attracted a lot of interest from natural product scientists for their efficacy and safety and their significant contribution towards understanding targeted drug action and drug delivery mechanisms. Zerumbone, the main constituent of Zingiber zerumbet rhizomes, has been investigated for its wide-spectrum role in treating multitargeted diseases. The rhizomes have been used as food flavoring agents in various cuisines and in herbal medicine. Many in vivo and in vitro studies have provided evidence of zerumbone as a potent immunomodulator as well as a potential anti-cancer agent...
July 17, 2017: Food & Function
https://www.readbyqxmd.com/read/28713492/salvianolic-acid-exerts-cardioprotection-through-promoting-angiogenesis-in-animal-models-of-acute-myocardial-infarction-preclinical-evidence
#14
REVIEW
Long-Jie Yu, Ke-Jian Zhang, Jia-Zhen Zhu, Qun Zheng, Xiao-Yi Bao, Saroj Thapa, Yan Wang, Mao-Ping Chu
Radix Salviae miltiorrhizae, danshen root (danshen), is one of the widely used Chinese herbal medicines in clinics, containing rich phenolic compounds. Salvianolic acid is the main active compound responsible for the pharmacologic effects of danshen. Here, we aimed to evaluate the effects of salvianolic acid on cardioprotection through promoting angiogenesis in experimental myocardial infarction. Studies of salvianolic acid in animal models of myocardial infarction were obtained from 6 databases until April 2016...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28712867/anti-inflammatory-and-anti-oxidant-effects-of-apigetrin-on-lps-induced-acute-lung-injury-by-regulating-nrf2-and-ampk-pathways
#15
Xiang-Hua Lin, Jin-Bing Pan, Xiao-Ju Zhang
Apigetrin (Api), a flavonoid isolated from various herbal medicines such as Matricaria chamomilla and Scutellaria baicalensis Georgi, shows significant anti-inflammatory and anti-oxidative bioactivities. Here, we attempted to explore the protect effects of Api on LPS-induced acute lung injury (ALI). Our results indicated that Api extended the survival rate and ameliorated pathogenic processes in lipopolysaccharide (LPS)-induced mice. But nuclear factor erythroid 2-related factor 2 (Nrf2) deletion may impede protective effect of Api...
July 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28712477/phytochemical-analysis-and-cytotoxicity-evaluation-of-kelussia-odoratissima-mozaff
#16
Amir Abbas Momtazi, Omid Askari-Khorasgani, Elham Abdollahi, Hojjat Sadeghi-Aliabadi, Forough Mortazaeinezhad, Amirhossein Sahebkar
BACKGROUND: Kelussia odoratissima Mozaff. (Apiaceae) is an edible, indigenous, and ethnomedicinal plant that grows only in Iran. Although antioxidant and anti-inflammatory properties of K. odoratissima have been reported, cytotoxic activity of this plant has not been investigated previously. OBJECTIVE: This study aims to evaluate the cytotoxicity of K. odoratissima leaf extract against a panel of human cancer cell lines. A secondary aim was to perform a phytochemical analysis of the plant's leaf oil...
June 2017: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/28712474/postherpetic-neuralgia-practical-experiences-return-to-traditional-chinese-medicine
#17
REVIEW
Majid Avijgan, Seyedeh Tahoora Hajzargarbashi, Aliasghar Kamran, Mahtab Avijgan
Post-herpetic neuralgia (PHN) is a complication of herpes zoster that can cause different types of pain in the affected area. It often occurs mainly in severe cases of herpes zoster. The problem is defined as a persisting pain for 90-120 days after relieving of acute phase of herpes lesions. This complication causes suffering in patients and reduces the quality of life. In western medicine's viewpoints, PHN is due to disturbance in local and dermatomal nerves. There are several topical and systemic drugs that are used to manage the pain relief...
June 2017: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/28712058/reliance-on-medicinal-plant-therapy-among-cancer-patients-in-jamaica
#18
Kimberley Foster, Novie Younger, William Aiken, Doreen Brady-West, Rupika Delgoda
PURPOSE: Patients' perspective of their treatment regime plays a vital role in its success. Recognizing the high prevalence of medicinal plant usage among Jamaicans at large, we investigated the engagement of such remedies by cancer patients, with the aim of uncovering self-medicating habits, perceptions and details of utilized plants. METHODS: A structured, interviewer-based questionnaire was administered to 100 patients attending the oncology and urology clinics at the University Hospital of the West Indies in Kingston, Jamaica...
July 15, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28710372/phthalide-derivatives-from-angelica-sinensis-decrease-hemoglobin-oxygen-affinity-a-new-allosteric-modulating-mechanism-and-potential-use-as-2-3-bpg-functional-substitutes
#19
Wei-Ren Chen, Youqing Yu, Muhammad Zulfajri, Ping-Cheng Lin, Chia C Wang
Angelica sinensis (AS), one of the most versatile herbal medicines remains widely used due to its multi-faceted pharmacologic activities. Besides its traditional use as the blood-nourishing tonic, its anti-hypertensive, anti-cardiovascular, neuroprotective and anti-cancer effects have been reported. Albeit the significant therapeutic effects, how AS exerts such diverse efficacies from the molecular level remains elusive. Here we investigate the influences of AS and four representative phthalide derivatives from AS on the structure and function of hemoglobin (Hb)...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28709569/selected-active-naturals-for-atopic-dermatitis-atopic-dermatitis-part-1
#20
Nanette B Silverberg
The desire for naturally derived agents is a growing trend for patients, physicians, and pharmaceutical companies. Studies indicate that complementary and alternative medicine is often used by patients and parents of children with atopic dermatitis, not necessarily with beneficial results. A half-dozen natural agents (ie, topical agents: coconut oil, colloidal oatmeal, sunflower oil, mustard oil, glycerin, and oral Chinese herbal therapy) are discussed because they have become popular for their expected activity in the therapy of atopic dermatitis...
July 2017: Clinics in Dermatology
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