Zhihao Shang, Yiping Fan, Songyang Xi, Shang Zhang, Weixing Shen, Lihuiping Tao, Changliang Xu, Jiani Tan, Minmin Fan, Hongyue Ma, Yueyang Lai, Dongdong Sun, Haibo Cheng
BACKGROUND: Colorectal cancer (CRC) is a significant public health issue, ranking as one of the predominant cancer types globally in terms of incidence. Intriguingly, Arenobufagin (Are), a compound extracted from toad venom, has demonstrated the potential to inhibit tumor growth effectively. PURPOSE: This study aimed to explore Are's molecular targets and unravel its antitumor mechanism in CRC. Specifically, we were interested in its impact on immune checkpoint modulation and correlations with HSP90β-STAT3-PD-L1 axis activity...
February 28, 2024: Phytomedicine