keyword
https://read.qxmd.com/read/38655878/herbal-remedies-in-the-management-of-hyperuricemia-and-gout-a-review-of-in-vitro-in-vivo-and-clinical-evidences
#1
REVIEW
Mohamad Fawzi Mahomoodally, Kaisavadee Coodian, Muzzammil Hosenally, Gokhan Zengin, Mohammad Ali Shariati, Ashraf N Abdalla, Hassan A Alhazmi, Gulrana Khuwaja, Syam Mohan, Asaad Khalid
Gout, or hyperuricemia is a multifactorial and multi-faceted metabolic disease that is quite difficult to manage and/or treat. Conventional therapies such as non-steroidal anti-inflammatory drugs (NSAIDs) such as allopurinol, corticosteroids and colchicine amongst others, have helped in its management and treatment to some extent. This study aimed to compile and analyze the different herbal remedies used in the management of hyperuricemia and gout. A literature search was conducted from key databases (PubMed, ScienceDirect, Cochrane Library, Google Scholar) using relevant keywords via the PRISMA model...
April 24, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38654786/perception-and-use-of-herbal-medicine-in-general-practice-patients-a-cross-sectional-study-in-saudi-arabia
#2
JOURNAL ARTICLE
Hiba H Ali, Shaima F Alharbi, Rahaf A Iskandar, Ghazal B Mira, Adama S Yanogue, Ehab A Alboualy
BACKGROUND: In Saudi Arabia, herbal medicine is an essential component of traditional health practices, reflecting a deep cultural appreciation for natural remedies. Despite widespread use, comprehensive data on perceptions and utilization among general practice patients are scarce. This study aims to elucidate the patterns of herbal medicine use, associated beliefs, and communication with healthcare professionals in this context. METHODS: A cross-sectional survey was conducted using an online questionnaire distributed through social media and professional networks, targeting adult residents of Saudi Arabia...
March 2024: Curēus
https://read.qxmd.com/read/38653154/the-pathological-mechanisms-and-potential-therapeutic-drugs-for-myocardial-ischemia-reperfusion-injury
#3
REVIEW
Shuo Zhang, Fei Yan, Fei Luan, Yun Chai, Na Li, Yu-Wei Wang, Zhen-Lin Chen, Ding-Qiao Xu, Yu-Ping Tang
BACKGROUND: Cardiovascular disease is the main cause of death and disability, with myocardial ischemia being the predominant type that poses a significant threat to humans. Reperfusion, an essential therapeutic approach, promptly reinstates blood circulation to the ischemic myocardium and stands as the most efficacious clinical method for myocardial preservation. Nevertheless, the restoration of blood flow associated with this process can potentially induce myocardial ischemia-reperfusion injury (MIRI), thereby diminishing the effectiveness of reperfusion and impacting patient prognosis...
April 16, 2024: Phytomedicine
https://read.qxmd.com/read/38652404/n-methyl-d-aspartate-receptors-and-thymoquinone-induce-apoptosis-and-alteration-in-mitochondria-in-colorectal-cancer-cells
#4
JOURNAL ARTICLE
Ferhat Sirinyildiz, Simge Unay
Colon cancer is on the rise in both men and women. In addition to traditional treatment methods, herbal treatments from complementary and alternative medicine are actively followed. Naturally derived from plants, thymoquinone (TQ) has drawn a lot of attention in the field of cancer treatment. MK-801, an N-methyl-D-aspartate agonist, is used to improve memory and plasticity, but it has also lately been explored as a potential cancer treatment. This study aimed to determine the roles of N-Methyl-D-Aspartate agonists and Thymoquinone on mitochondria and apoptosis...
April 23, 2024: Medical Oncology
https://read.qxmd.com/read/38651884/identification-and-characterization-of-a-novel-antifungal-compound-tubeimoside-i-targeting-cell-wall
#5
JOURNAL ARTICLE
Qiannan Liu, Zhiqi Zhong, Shunxin Zheng, Yunzhuo Chu, Norihiro Sakamoto, Takayoshi Kuno, Yue Fang
UNLABELLED: Due to fungal diseases that threaten immunocompromised patients, along with the limited availability of antifungal agents, there is an urgent need for new antifungal compounds to treat fungal infections. Here, we aimed to identify potential antifungal drugs from natural products using the fission yeast Schizosaccharomyces pombe as a model organism since it shares many features with some pathogenic fungi. Here, we identified tubeimoside I (TBMS1), an extract from Chinese herbal medicine, that showed strong antifungal activity against S...
April 23, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38646565/computational-and-experimental-strategies-for-combating-mbl-p-aeruginosa-mblpa-biofilms-using-phytochemicals-targeting-the-quorum-sensing-network
#6
JOURNAL ARTICLE
Maryum Fakhar, Mehboob Ahmed, Anjum Nasim Sabri
Pseudomonas aeruginosa is a Gram-negative opportunistic bacterium, ubiquitously found in nature and causative agent in many infections. Due to increased antibiotic resistance, there is a need to develop more robust antibacterial agents from natural sources. In this study, we worked on two metallo-β-lactamase (MBL) producing Pseudomonas aeruginosa strains and targeted the Quorum Sensing mechanism (QS) of these bacteria to combat antibiotic resistance. Our study aimed at using phytochemicals which have been used since centuries in herbal medicine...
June 2024: Saudi Journal of Biological Sciences
https://read.qxmd.com/read/38645751/mitigating-digestive-disorders-action-mechanisms-of-mediterranean-herbal-active-compounds
#7
REVIEW
Abdalsalam Kmail
This study explores the effects of the Mediterranean diet, herbal remedies, and their phytochemicals on various gastrointestinal conditions and reviews the global use of medicinal plants for common digestive problems. The review highlights key plants and their mechanisms of action and summarizes the latest findings on how plant-based products influence the digestive system and how they work. We searched various sources of literature and databases, including Google Scholar, PubMed, Science Direct, and MedlinePlus...
2024: Open Life Sciences
https://read.qxmd.com/read/38645561/anti-inflammatory-and-protective-effects-of-pimpinella-candolleana-on-ulcerative-colitis-in-rats-a-comprehensive-study-of-quality-chemical-composition-and-molecular-mechanisms
#8
JOURNAL ARTICLE
Xiaoqi Liu, Hai Xiao, Mingxia Luo, Junpeng Meng, Lin Zhong, Tao Wu, Yongxia Zhao, Faming Wu, Jian Xie
Introduction: P. candolleana Wight et Arn. Is a traditional Chinese herbal medicine used by the Gelao nationality in southwest China, has been historically applied to treat various gastrointestinal disorders. Despite its traditional usage, scientific evidence elucidating its efficacy and mechanisms in treating ulcerative colitis (UC) remains sparse. This study aimed to determine the quality and chemical composition of Pimpinella candolleana and to identify its potential therapeutic targets and mechanisms in acetic acid-induced ulcerative colitis (UC) rats through integrated approaches...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38643715/artificial-aging-conditions-for-artemisia-argyi-leaves-based-on-quality-inflammation-quality-marker-transformation
#9
JOURNAL ARTICLE
Xiuli Guo, DongPeng Wang, Yangxin Xiao, Huangliang Cao, Ding Yao, Gaoyuan Chen, Shuiqing Li, Guangzhong Wang, Jiyuan Tu, Yanju Liu
BACKGROUND: Appropriate conditions for storage of Artemisia argyi leaves reduce irritation during treatment and increase the active ingredient content. Naturally aged A. argyi leaves (≥1 year) are optimal for moxibustion; however, this process is time-consuming and costly. A comprehensive understanding of the conditions for artificial aging of A. argyi leaves and the mechanism of quality-marker conversion are required to guarantee A. argyi quality and moxibustion efficacy. OBJECTIVE: To identify the optimal conditions for artificial aging of A...
April 16, 2024: Phytomedicine
https://read.qxmd.com/read/38643714/integrated-pharmacokinetic-properties-and-tissue-distribution-of-multiple-active-constituents-in-qing-yi-recipe-a-comparison-between-granules-and-decoction
#10
JOURNAL ARTICLE
Shurong Ma, Tianfu Wei, Biao Zhang, Yunshu Zhang, Jinwen Lai, Jialin Qu, Jianjun Liu, Peiyuan Yin, Dong Shang
BACKGROUND: Qing-Yi Recipe, a classic traditional Chinese medicine (TCM), is widely used for treating acute diseases of the abdomen, especially pancreatitis, the efficacy of which has been demonstrated in more than thirty clinical trials. However, the in-vivo pharmacodynamic material basis for this formula remains unclear. METHODS: A sensitive and accurate method for quantifying twenty-two potential bioactive constituents of Qing-Yi Recipe in biological samples was developed using liquid chromatography-tandem mass spectrometry (LC-MS/MS), and this method was fully validated...
April 15, 2024: Phytomedicine
https://read.qxmd.com/read/38642413/targeting-cd8-t-cells-with-natural-products-for-tumor-therapy-revealing-insights-into-the-mechanisms
#11
REVIEW
Yuke Wang, Yan Zeng, Wenyong Yang, Xiuxuan Wang, Jingwen Jiang
BACKGROUND: Despite significant advances in cancer immunotherapy over the past decades, such as T cell-engaging chimeric antigen receptor (CAR)-T cell therapy and immune checkpoint blockade (ICB), therapeutic failure resulting from various factors remains prevalent. Therefore, developing combinational immunotherapeutic strategies is of great significance for improving the clinical outcome of cancer immunotherapy. Natural products are substances that naturally exist in various living organisms with multiple pharmacological or biological activities, and some of them have been found to have anti-tumor potential...
April 8, 2024: Phytomedicine
https://read.qxmd.com/read/38640855/arenobufagin-enhances-t-cell-anti-tumor-immunity-in-colorectal-cancer-by-modulating-hsp90%C3%AE-accessibility
#12
JOURNAL ARTICLE
Zhihao Shang, Yiping Fan, Songyang Xi, Shang Zhang, Weixing Shen, Lihuiping Tao, Changliang Xu, Jiani Tan, Minmin Fan, Hongyue Ma, Yueyang Lai, Dongdong Sun, Haibo Cheng
BACKGROUND: Colorectal cancer (CRC) is a significant public health issue, ranking as one of the predominant cancer types globally in terms of incidence. Intriguingly, Arenobufagin (Are), a compound extracted from toad venom, has demonstrated the potential to inhibit tumor growth effectively. PURPOSE: This study aimed to explore Are's molecular targets and unravel its antitumor mechanism in CRC. Specifically, we were interested in its impact on immune checkpoint modulation and correlations with HSP90β-STAT3-PD-L1 axis activity...
February 28, 2024: Phytomedicine
https://read.qxmd.com/read/38633661/apigetrin-alleviates-intervertebral-disk-degeneration-by-regulating-nucleus-pulposus-cell-autophagy
#13
JOURNAL ARTICLE
Tao Xu, Hongqi Zhao, Jian Li, Xuan Fang, Hua Wu, Weihua Hu
BACKGROUND: Intervertebral disk degeneration (IVDD) is a common spine disease, and inflammation is considered to be one of its main pathogenesis. Apigetrin (API) is a natural bioactive flavonoid isolated from various herbal medicines and shows attractive anti-inflammatory and antioxidative properties; whereas, there is no exploration of the therapeutic potential of API on IVDD. Here, we aim to explore the potential role of API on IVDD in vivo and in vitro. METHODS: In vitro, western blotting, real-time quantitative polymerase chain reaction, and immunofluorescence analysis were implemented to explore the bioactivity of API on interleukin-1 beta (IL-1β)-induced inflammatory changes in nucleus pulposus cells (NPCs)...
June 2024: JOR Spine
https://read.qxmd.com/read/38631920/exotic-animal-practice-in-africa
#14
REVIEW
Johannes Lodewicus Coetzee de Beer
This article explores the evolution, unique aspects, and challenges facing exotic animal practice in South Africa. This article delves into the slow emergence of dedicated exotic practices and the challenges faced by veterinarians in a vast and diverse landscape. The unique nature of the veterinary landscape is highlighted, emphasizing the impact of varied climates on species inhabiting different regions. The challenges are multifaceted, ranging from limited education infrastructure to dietary issues, unregulated feeds, and the complexities of herbal medicine use...
April 16, 2024: Veterinary Clinics of North America. Exotic Animal Practice
https://read.qxmd.com/read/38629105/efficacy-and-classification-of-sesamum-indicum-linn-seeds-with-rosa-damascena-mill-oil-in-uncomplicated-pelvic-inflammatory-disease-using-machine-learning
#15
JOURNAL ARTICLE
Sumbul, Arshiya Sultana, Md Belal Bin Heyat, Khaleequr Rahman, Faijan Akhtar, Saba Parveen, Mercedes Briones Urbano, Vivian Lipari, Isabel De la Torre Díez, Azmat Ali Khan, Abdul Malik
Background and objectives: As microbes are developing resistance to antibiotics, natural, botanical drugs or traditional herbal medicine are presently being studied with an eye of great curiosity and hope. Hence, complementary and alternative treatments for uncomplicated pelvic inflammatory disease (uPID) are explored for their efficacy. Therefore, this study determined the therapeutic efficacy and safety of Sesamum indicum Linn seeds with Rosa damascena Mill Oil in uPID with standard control. Additionally, we analyzed the data with machine learning...
2024: Frontiers in Chemistry
https://read.qxmd.com/read/38627601/demographic-social-and-clinical-aspects-associated-with-access-to-covid-19-health%C3%A2-care-in-par%C3%A3-province-brazilian-amazon
#16
JOURNAL ARTICLE
Amanda Loyse da Costa Miranda, Ana Rosa Tavares da Paixão, Andrey Oeiras Pedroso, Laís do Espírito Santo Lima, Andressa Tavares Parente, Eliã Pinheiro Botelho, Sandra Helena Isse Polaro, Ana Cristina de Oliveira E Silva, Renata Karina Reis, Glenda Roberta Oliveira Naiff Ferreira
Internal social disparities in the Brazilian Amazon became more evident during the COVID-19 pandemic. The aim of this work was to examine the demographic, social and clinical factors associated with access to COVID-19 health care in Pará Province in the Brazilian Amazon. This was an observational, cross-sectional, analytical study using a quantitative method through an online survey conducted from May to August 2023. People were eligible to participate if they were current residents of Pará, 18-years-old or older, with self-reported diagnoses of COVID-19 through rapid or laboratory tests...
April 16, 2024: Scientific Reports
https://read.qxmd.com/read/38626651/assessment-of-cancer-risk-and-radiological-effects-from-210-po-and-210-pb-with-consumption-of-wild-medicinal-herbal-plants
#17
JOURNAL ARTICLE
Aleksandra Moniakowska, Dagmara Strumińska-Parulska
BACKGROUND: Plants' raw materials can accumulate chemical elements, including radioisotopes, to some extent and reflect the region they grow in. Due to their high environmental content and toxicity, natural radionuclides - polonium 210 Po and lead 210 Pb are the most dangerous radioisotopes for human health. METHODS: 70 raw medicinal herbal materials from 54 popular wild-growing medicinal plant species, most of them included in the European Pharmacopoeia, were collected across three regions...
April 14, 2024: Journal of Trace Elements in Medicine and Biology
https://read.qxmd.com/read/38621464/traditional-herbal-medicine-therapeutic-potential-in-acute-gouty-arthritis
#18
REVIEW
Siwei Wang, Wei Liu, Bowen Wei, Aihua Wang, Yiwen Wang, Wen Wang, Jingyue Gao, Yue Jin, Hang Lu, Yuxiu Ka, Qingyun Yue
ETHNOPHARMACOLOGICAL RELEVANCE: Acute Gouty Arthritis (AGA) is characterized by a rapid inflammatory reaction caused by the build-up of monosodium urate (MSU) crystals in the tissues surrounding the joints. This condition often associated with hyperuricemia, is distinguished by its symptoms of intense pain, active inflammation, and swelling of the joints. Traditional approaches in AGA management often fall short of desired outcomes in clinical settings. However, recent ethnopharmacological investigations have been focusing on the potential of Traditional Herbal Medicine (THM) in various forms, exploring their therapeutic impact and targets in AGA treatment...
April 13, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38621328/aloe-emodin-alleviates-cerebral-ischemia-reperfusion-injury-by-regulating-microglial-polarization-and-pyroptosis-through-inhibition-of-nlrp3-inflammasome-activation
#19
JOURNAL ARTICLE
Xun Li, Minghe Yao, Lingling Li, Huifen Ma, Yiran Sun, Xiangpeng Lu, Weipeng Jing, Shanshan Nie
BACKGROUND: Microglial activation plays a crucial role in injury and repair after cerebral ischemia, and microglial pyroptosis exacerbates ischemic injury. NOD-like receptor protein 3 (NLRP3) inflammasome activation has an important role in microglial polarization and pyroptosis. Aloe-emodin (AE) is a natural anthraquinone compound originated from rhubarb and aloe. It exerts antioxidative and anti-apoptotic effects during cerebral ischemia/reperfusion (I/R) injury. However, whether AE affects microglial polarization, pyroptosis, and NLRP3 inflammasome activation remains unknown...
April 7, 2024: Phytomedicine
https://read.qxmd.com/read/38614262/essential-oils-for-clinical-aromatherapy-a-comprehensive-review
#20
REVIEW
Lalitkumar K Vora, Amol D Gholap, Navnath T Hatvate, Padmashri Naren, Sabiya Khan, Vivek P Chavda, Pankti C Balar, Jimil Gandhi, Dharmendra Kumar Khatri
ETHNOPHARMACOLOGICAL RELEVANCE: Aromatherapy, a holistic healing practice utilizing the aromatic essences of plant-derived essential oils, has gained significant attention for its therapeutic potential in promoting overall well-being. Use of phytoconstituent based essential oil has played a significant role in the evolving therapeutic avenue of aromatherapy as a complementary system of medicine. AIM OF THE STUDY: This comprehensive review article aims to explore the usage of essential oils for aromatherapy, shedding light on their diverse applications, scientific evidence, and safety considerations...
April 11, 2024: Journal of Ethnopharmacology
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