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https://www.readbyqxmd.com/read/27910928/high-throughput-chinmedomics-based-prediction-of-effective-components-and-targets-from-herbal-medicine-as1350
#1
Qi Liu, Aihua Zhang, Liang Wang, Guangli Yan, Hongwei Zhao, Hui Sun, Shiyu Zou, Jinwei Han, Chung Wah Ma, Ling Kong, Xiaohang Zhou, Yang Nan, Xijun Wang
This work was designed to explore the effective components and targets of herbal medicine AS1350 and its effect on "Kidney-Yang Deficiency Syndrome" (KYDS) based on a chinmedomics strategy which is capable of directly discovering and predicting the effective components, and potential targets, of herbal medicine. Serum samples were analysed by UPLC-MS combined with pattern recognition analysis to identify the biomarkers related to the therapeutic effects. Interestingly, the effectiveness of AS1350 against KYDS was proved by the chinmedomics method and regulated the biomarkers and targeting of metabolic disorders...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27896487/natural-compounds-as-occult-ototoxins-ginkgo-biloba-flavonoids-moderately-damage-lateral-line-hair-cells
#2
Sarah Neveux, Nicole K Smith, Anna Roche, Bruce E Blough, Wimal Pathmasiri, Allison B Coffin
Several drugs, including aminoglycosides and platinum-based chemotherapy agents, are well known for their ototoxic properties. However, FDA-approved drugs are not routinely tested for ototoxicity, so their potential to affect hearing often goes unrecognized. This issue is further compounded for natural products, where there is a lack of FDA oversight and the manufacturer is solely responsible for ensuring the safety of their products. Natural products such as herbal supplements are easily accessible and commonly used in the practice of traditional eastern and alternative medicine...
November 28, 2016: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/27881119/antibacterial-and-antifungal-potentials-of-the-solvents-extracts-from-eryngium-caeruleum-notholirion-thomsonianum-and-allium-consanguineum
#3
Abdul Sadiq, Sadiq Ahmad, Rahmat Ali, Fawad Ahmad, Sajjad Ahmad, Anwar Zeb, Muhammad Ayaz, Farhat Ullah, Abu Nasar Siddique
BACKGROUND: Herbal medicines have long been used for various ailments in various societies and natural bioactive compounds are gaining more and more importance due to various factors. In this context, three plant species i.e., Eryngium caeruleum, Notholirion thomsonianum and Allium consanguineum have been aimed for the scientific verification of their purported traditional uses against various infectious diseases. METHODS: In this study, three plants were assayed for antibacterial and antifungal potentials...
November 24, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27881059/natural-products-with-antiplatelet-action
#4
Gabriela Elisa Hirsch, Paulo Ricardo Nazário Viecili, Amanda Spring de Almeida, Sabrina Nascimento, Fernando Garcez Porto, Juliana Otero, Aline Schmidt, Brenda da Silva, Mariana Migliorini Parisi, Jonatas Zeni Klafke
BACKGROUND: Complex hemostatic mechanisms are involved in the pathophysiology of various diseases, including cardiovascular diseases. Among them, dysregulation of platelet activity is linked to the progression of atherosclerosis and mainly involves platelet aggregation and a decrease in blood flow in the vascular endothelium. The major platelet activation pathways mediated by agonists involve the arachidonic acid pathway, adenosine diphosphate pathway, serotonin pathway, nitric oxide pathway, and action of free radicals on molecules involved in platelet aggregation...
November 23, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27868087/diabetic-wound-healing-and-activation-of-nrf2-by-herbal-medicine
#5
Donald R Senger, Shugeng Cao
Nrf2 defense is a very important cellular mechanism to control oxidative stress, which is implicated in wound healing. Nrf2 can induce many cytoprotective genes, including HO-1, NQO1 and G6PD. Among many natural products that have been reported as Nrf2 activators, sulforaphane and curcumin have been studied more widely than any others, and both are in clinical trials for non-cancerous disorders. Recently, we reported 4-ethyl catechol and 4-vinyl catechol as Nrf2 co-factors that can induce Nrf2 as potently as sulforaphane and curcumin...
2016: Journal of Nature and Science
https://www.readbyqxmd.com/read/27861946/saffron-a-promising-natural-medicine-in-the-treatment-of-metabolic-syndrome
#6
REVIEW
Bibi Marjan Razavi, Hossein Hosseinzadeh
Metabolic syndrome is a disorder which encompasses with obesity, high blood glucose, high cholesterol levels and high blood pressure. Moreover metabolic syndrome is considered as the most important risk factor for cardiovascular disease (CVD). CVD is the leading cause of mortality in the world for both men and women. Although several chemical drugs are available to treat metabolic risk factors, however, because of the safety, efficacy, cultural acceptability and lesser side effects, nowadays herbal therapy has a critical role in the treatment of these CVD risk factors...
November 12, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27845865/gastrodia-elata-blume-extract-modulates-antioxidant-activity-and-ultraviolet-a-irradiated-skin-aging-in-human-dermal-fibroblast-cells
#7
Eunju Song, Haeyon Chung, Eugene Shim, Jung-Ky Jeong, Bok-Kyung Han, Hyuk-Joon Choi, Jinah Hwang
Gastrodia elata Blume (GEB), a traditional herbal medicine, has been used to treat a wide range of neurological disorders (e.g., paralysis and stroke) and skin problems (e.g., atopic dermatitis and eczema) in oriental medicine. This study was designed to investigate the antioxidant ability of GEB and its antiaging effect on human dermal fibroblast cells (HDF). The total phenolic and flavonoid contents of GEB were 21.8 and 0.43 mg/g dry weight (DW), respectively. The ergothioneine content of GEB was 0.41 mg/mL DW...
November 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27834124/gymnema-sylvestre-for-diabetes-from-traditional-herb-to-future-s-therapeutic
#8
Pragya Tiwari, Khurshid Ahmad, Mohammad Hassan Baig
Diabetes has increased at an unprecedented rate and is fast emerging as a global threat worldwide. The focus on pharmacological studies pertaining to diabetes has seen a remarkable shift from conventional medicines to therapeutics employing bioactive phytomolecules from natural sources. The prospective effectiveness of natural products together with their low cost and minimal side effects has revolutionized the entire concept of drug discovery and management programs. One such beneficial herb is Gymnema sylvestre, possessing remarkable hypoglycemic properties and forms the platform of diabetes therapeutics in the traditional system of medication...
November 8, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27818233/systems-biology-dissection-of-mechanisms-and-chemical-basis-of-herbal-formula-in-treating-chronic-myocardial-ischemia
#9
Shuzhen Guo, Peng Li, Bangze Fu, Wenjing Chuo, Kuo Gao, Wuxia Zhang, Junyao Wang, Jianxin Chen, Wei Wang
Herbal medicine is a mixture of multiple compounds, and is intended to exhibit therapeutic effects by attacking multiple disease-causing modules simultaneously. However, it is still a challenge for scientists to untangle the complex biological mechanisms and underlying material basis of herbal medicine. Here, this study was designed to build a systems-biology platform for exploring the molecular mechanisms and corresponding active compounds, with a typical example applied to an herbal formula Qishenkel (QSKL) in the treatment of chronic myocardial ischemia...
November 3, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27806472/analytical-assessment-of-belief-about-medicine-among-patients-with-hypertension-a-case-study-on-patients-referred-to-medical-centers
#10
Mohammad Edris Arbabshastan, Azizollah Arbabisarjou, Iraj Zareban, Mahlagha Dehghan, Saeed Pakdel, Sedigheh Iranmanesh
INTRODUCTION & OBJECTIVE: Hypertension (HTN) is one of the major health problems in many countries. Medicinal treatments and lifestyle modification have so far failed to effectively influence blood pressure control. Hence, this study intended to analytically assess the belief about medicine among hypertensive patients who referred to medical centers during 2015. MATERIALS & METHODS: This was a descriptive-analytical, cross-sectional study. The population consisted of all patients who referred to health centers and doctors' offices for internal medicine and heart diseases...
June 30, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27804869/advances-in-medicinal-plants-with-effects-on-anxiety-behavior-associated-to-mental-and-health-conditions
#11
Valentina Echeverria, Gjumrakch Aliev, Madeline Foitzick, Marco Ávila-Rodriguez, George E Barreto
BACKGROUND: Many mental health conditions including psychiatric disorders and neurodegenerative conditions are poorly responsive to actual medications or have low patient adherence to treatment due to the side effects or costs associated with these treatments. OBJECTIVE: The main goal of this review is to provide clinical providers and patients with actualized information about the efficacy of selected herbal medicines for anxiety disorders derived from mental and/or health conditions, and their associated side effects...
November 1, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27800127/effects-of-pistacia-atlantica-subsp-kurdica-on-growth-and-aflatoxin-production-by-aspergillus-parasiticus
#12
Sadegh Khodavaisy, Sassan Rezaie, Fatemeh Noorbakhsh, Elham Baghdadi, Somayeh Sharifynia, Farzad Aala
BACKGROUND: Aflatoxins are highly toxic secondary metabolites mainly produced by Aspergillus parasiticus. This species can contaminate a wide range of agricultural commodities, including cereals, peanuts, and crops in the field. In recent years, research on medicinal herbs, such as Pistacia atlantica subsp. kurdica, have led to reduced microbial growth, and these herbs also have a particular effect on the production of aflatoxins as carcinogenic compounds. OBJECTIVES: In this study, we to examine P...
July 2016: Jundishapur Journal of Microbiology
https://www.readbyqxmd.com/read/27794498/phytomedicine-modulating-oxidative-stress-and-the-tumor-microenvironment-for-cancer-therapy
#13
REVIEW
Yu-Ting Cheng, Chun-Chih Yang, Lie-Fen Shyur
In spite of the current advances and achievements in systems biology and translational medicinal research, the current strategies for cancer therapy, such as radiotherapy, targeted therapy, immunotherapy and chemotherapy remain palliative or unsatisfactory due to tumor metastasis or recurrence after surgery/therapy, drug resistance, adverse side effects, and so on. Oxidative stress (OS) plays a critical role in chronic/acute inflammation, carcinogenesis, tumor progression, and tumor invasion/metastasis which is also attributed to the dynamic and complex properties and activities in the tumor microenvironment (TME)...
October 26, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27781071/bioactive-natural-molecules-and-traditional-herbal-medicine-in-the-treatment-of-airways-diseases
#14
EDITORIAL
Alexandre de Paula Rogerio, Troy Carlo, Sergio R Ambrosio
No abstract text is available yet for this article.
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27780398/microbial-cooperation-in-the-rhizosphere-improves-liquorice-growth-under-salt-stress
#15
Dilfuza Egamberdieva, Stephan Wirth, Li Li, Elsayed Fathi Abd-Allah, Kristina Lindström
Liquorice (Glycyrrhiza uralensis Fisch.) is one of the most widely used plants in food production, and it can also be used as an herbal medicine or for reclamation of salt-affected soils. Under salt stress, inhibition of plant growth, nutrient acquisition and symbiotic interactions between the medicinal legume liquorice and rhizobia have been observed. We recently evaluated the interactions between rhizobia and root-colonizing Pseudomonas in liquorice grown in potting soil and observed increased plant biomass, nodule numbers and nitrogen content after combined inoculation compared to plants inoculated with Mesorhizobium alone...
October 26, 2016: Bioengineered
https://www.readbyqxmd.com/read/27776377/saponins-and-flavonoids-from-an-infusion-of-herniaria-hirsuta
#16
Ines van Dooren, Kenn Foubert, Sebastiaan Bijttebier, Mart Theunis, Stefaniya Velichkova, Magda Claeys, Luc Pieters, Vassiliki Exarchou, Sandra Apers
Stone diseases present a major health problem in the Western society, since both urinary and biliary stones occur with a relatively high prevalence of 10-12 % and 10-20 %, respectively, and demonstrate a high recurrence rate. At the moment treatment is mainly based on interventional procedures, or prophylactic and dissolution therapy. However, many of the current drugs cause severe side effects, and therefore, there is an increasing interest in natural medicines. At the moment no registered herbal medicinal products are available for treatment of gallstones...
October 24, 2016: Planta Medica
https://www.readbyqxmd.com/read/27775193/draft-genome-assembly-and-annotation-of-glycyrrhiza-uralensis-a-medicinal-legume
#17
Keiichi Mochida, Tetsuya Sakurai, Hikaru Seki, Takuhiro Yoshida, Kotaro Takahagi, Satoru Sawai, Hiroshi Uchiyama, Toshiya Muranaka, Kazuki Saito
Chinese liquorice/licorice (Glycyrrhiza uralensis) is a leguminous plant species whose roots and rhizomes have been widely used as a herbal medicine and natural sweetener. Whole-genome sequencing is essential for gene discovery studies and molecular breeding in liquorice. Here, we report a draft assembly of the approximately 379-Mb whole-genome sequence of strain 308-19 of G. uralensis; this assembly contains 34 445 predicted protein-coding genes. Comparative analyses suggested well-conserved genomic components and collinearity of gene loci (synteny) between the genome of liquorice and those of other legumes such as Medicago and chickpea...
October 24, 2016: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/27773803/the-genus-boschniakia-in-china-an-ethnopharmacological-and-phytochemical-review
#18
Le Zhang, Yunshan Zhao, Zhipeng A Wang, Kunhua Wei, Bin Qiu, Chunhong Zhang, QiYan Wang-Müller, Minhui Li
ETHNOPHARMACOLOGICAL RELEVANCE: As a group of important medicine plants, Boschniakia rossica (Cham. et Schltdl) Fedtsch. and B. himalaica Hook.f.et Thoms, which are the only two species in the genus Boschniakia (Orobanchaceae), have long been used in traditional Chinese medicine for their multiple therapeutic uses related to enhanced renal function, erectile dysfunction, defaecate and hepatoprotective. Additionally, the two species are also used as dietary supplements in wine, cosmetics, and other healthy food...
October 20, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27758689/mechanisms-of-anorexia-cancer-cachexia-syndrome-and-potential-benefits-of-traditional-medicine-and-natural-herbs
#19
Cong Ming-Hua, Zou Bao-Hua, Yu Lei
Anorexia cancer cachexia syndrome is prevalent in advanced cancer patients, which is featured by anorexia, decreased dietary intake, body weight loss (skeletal muscle mass loss), and unable to be reversed by routine nutritional support therapy. Up to now, the main mechanisms involved in cancer cachexia include excessive systemic inflammation, which is represented by increased plasma levels of IL-1, IL-6, TNF-alpha, tumor-induced factors, such as PIF and LMF. These factors eventually act on orexigenic and anorexigenic neurons located in hypothalamus or protein and lipid metabolism of peripheral tissues, which lead to anorexia, decreased dietary intake, enhanced basic metabolism rate and hyper catabolism...
October 18, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27743873/complementary-and-alternative-medicines-used-by-patients-with-inflammatory-bowel-diseases
#20
Adam S Cheifetz, Robert Gianotti, Raphael Luber, Peter R Gibson
Patients and physicians often have many questions regarding the role of complementary and alternative medicines (CAMs), or non-allopathic therapies, for inflammatory bowel diseases (IBD). CAMs of various forms are used by more than half of patients with IBD during some point in their disease course. We summarize the available evidence for the most commonly used and discussed CAMs. We discuss evidence for the effects of herbs (such as cannabis and curcumin), probiotics, acupuncture, exercise, and mind-body therapy...
October 12, 2016: Gastroenterology
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