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https://www.readbyqxmd.com/read/28927244/gastric-subepithelial-mass-like-involvement-in-crohn-s-disease-another-upper-gastrointestinal-manifestation
#1
Can Gonen, Selvinaz Ozkara
No abstract text is available yet for this article.
September 12, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28926962/anti-nkg2d-mab-a-new-treatment-for-crohn-s-disease
#2
REVIEW
Kasper Vadstrup, Flemming Bendtsen
Crohn's disease (CD) and ulcerative colitis (UC) are immunologically-mediated, debilitating conditions resulting from destructive inflammation of the gastrointestinal tract. The pathogenesis of IBD is incompletely understood, but is considered to be the result of an abnormal immune response with a wide range of cell types and proteins involved. Natural Killer Group 2D (NKG2D) is an activating receptor constitutively expressed on human Natural Killer (NK), γδ T, mucosal-associated invariant T (MAIT), CD56⁺ T, and CD8⁺ T cells...
September 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28922695/strategies-for-detecting-colon-cancer-in-patients-with-inflammatory-bowel-disease
#3
REVIEW
William A Bye, Tran M Nguyen, Claire E Parker, Vipul Jairath, James E East
BACKGROUND: Patients with longstanding ulcerative colitis and colonic Crohn's disease have an increased risk of colorectal cancer (CRC) compared with the general population. This review assessed the evidence that endoscopic surveillance may prolong life by allowing earlier detection of CRC or its pre-cursor lesion, dysplasia, in patients with inflammatory bowel disease (IBD). OBJECTIVES: To assess the effectiveness of cancer surveillance programs for diagnosis of IBD-associated colorectal cancer and in reducing the mortality rate from colorectal cancer in patients with IBD...
September 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28922370/ileocolic-resection-is-associated-with-increased-susceptibility-to-injury-in-a-murine-model-of-colitis
#4
Troy Perry, Michael Laffin, Richard N Fedorak, Aducio Thiesen, Bryan Dicken, Karen L Madsen
Ileocolic resection (ICR) is the most common intestinal resection performed for Crohn's disease, with recurrences commonly occurring at the site of the anastomosis. This study used an animal model of ICR in wild-type mice to examine immunologic changes that developed around the surgical anastomosis and how these changes impacted gut responses to minor acute injury. ICR was performed in adult 129S1/SvlmJ mice and results compared with mice receiving sham or no surgery. Dextran sodium sulfate was given either on post-operative day 9 or day 24 to evaluate immune responses in the intestine both immediately following surgery and after a period of healing...
2017: PloS One
https://www.readbyqxmd.com/read/28922260/increased-risk-of-inflammatory-bowel-disease-in-a-population-based-cohort-study-of-patients-with-hirschsprung-disease
#5
Anna Löf Granström, Leila Amin, Henrik Arnell, Tomas Wester
OBJECTIVES: Hirschsprung disease (HSCR) has previously been associated with inflammatory bowel disease (IBD). There are no data to show how common this association is. The aim of this study was to assess the risk of IBD in individuals with HSCR in a population-based cohort. METHODS: This was a nationwide, population-based cohort study. The study exposure was HSCR and the study outcome was IBD. The cohort included all individuals with HSCR registered in the Swedish National Patient Register between 1964-2013 and ten age- and sex-matched controls per patient, randomly selected from the Swedish Population Register...
September 16, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28922257/endoscopic-and-histological-assessment-of-paediatric-inflammatory-bowel-disease-over-a-three-year-follow-up-period
#6
J J Ashton, Q Bonduelle, E Mossotto, T Coelho, A Batra, N A Afzal, B Vadgama, S Ennis, R M Beattie
OBJECTIVES: Discrepancies between Inflammatory bowel disease (IBD) endoscopic/histological extent are documented at diagnosis. It is unclear whether these differences persist through disease course, with potential impact on categorisation and management. We aimed to analyse the progression of disease over a 3-year period. METHODS: Patients aged < 17 years, diagnosed between 2010-2013 at Southampton Children's Hospital and followed-up for 3 years were eligible...
September 16, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28922253/long-term-efficacy-safety-and-immunogenicity-of-biosimilar-infliximab-after-one-year-in-a-prospective-nationwide-cohort
#7
Lorant Gonczi, Krisztina B Gecse, Zsuzsanna Vegh, Zsuzsanna Kurti, Mariann Rutka, Klaudia Farkas, Petra A Golovics, Barbara D Lovasz, Janos Banai, Laszlo Bene, Bea Gasztonyi, Tunde Kristof, Laszlo Lakatos, Pal Miheller, Ferenc Nagy, Karoly Palatka, Maria Papp, Arpad Patai, Agnes Salamon, Tamas Szamosi, Zoltan Szepes, Gabor T Toth, Aron Vincze, Balazs Szalay, Tamas Molnar, Peter L Lakatos
BACKGROUND: It has been previously shown that biosimilar infliximab CT-P13 is effective and safe in inducing remission in inflammatory bowel diseases. We report here the 1-year outcomes from a prospective nationwide inflammatory bowel disease cohort. METHODS: A prospective, nationwide, multicenter, observational cohort was designed to examine the efficacy and safety of CT-P13 in the induction and maintenance treatment of Crohn's disease (CD) and ulcerative colitis (UC)...
August 23, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28922251/shank3-regulates-intestinal-barrier-function-through-modulating-zo-1-expression-through-the-pkc%C3%AE%C2%B5-dependent-pathway
#8
Shu-Chen Wei, Hsin-Fang Yang-Yen, Po-Nien Tsao, Meng-Tzu Weng, Chien-Chih Tung, Linda C H Yu, Liang-Chuan Lai, Jen-Hao Hsiao, Eric Y Chuang, Chia-Tung Shun, Yen-Hsuan Ni, Ramnik J Xavier, Daniel K Podolsky, Jeffery J Y Yen, Jau-Min Wong
BACKGROUND: The integrity of the gut barrier in patients with inflammatory bowel disease is known to be impaired but the exact mechanisms remain mostly unknown. SHANK3 mutations are associated with autism, and patients with autism are known to have higher proportions of inflammatory bowel disease. Here, we explore the role of SHANK3 in inflammatory bowel disease, both in vivo and in vitro. METHODS: Dextran sulfate sodium colitis was induced in SHANK3 knockout mice...
August 23, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28922207/sweet-sixteen-the-prospective-clinical-trials-of-john-l-cameron-md-the-clinician-scientist-from-alternate-allocation-to-randomized-controlled-trials
#9
Charles J Yeo
: The era of randomized controlled trials was ushered in by the British epidemiologist-statistician Austin Bradford Hill, with his work on the use of streptomycin in patients with tuberculosis. John L. Cameron, can be linked to 16 prospective clinical trials over his career thus far, starting with alternate-allocation trials and transitioning to prospective, randomized, placebo-controlled trials. These trials studied various topics in surgery-from pancreatitis to surgical site infections, to drain trials, a trial in Crohn disease and multiple trials in pancreatic surgery and cancer...
September 15, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28919192/magnetic-resonance-index-of-activity-maria-and-clermont-score-are-highly-and-equally-effective-mri-indices-in-detecting-mucosal-healing-in-crohn-s-disease
#10
Anthony Buisson, Bruno Pereira, Marion Goutte, Maud Reymond, Christophe Allimant, Hélène Obritin-Guilhen, Gilles Bommelaer, Constance Hordonneau
BACKGROUND: Magnetic resonance index of activity (MaRIA) and Clermont score are currently the two main MRI indices that have been validated compared to endoscopy in Crohn's disease (CD). AIMS: To compare the accuracy of MaRIA and Clermont score in assessing CD mucosal healing. METHODS: Fourty-four CD patients underwent prospectively and consecutively MRI and colonoscopy. RESULTS: Considering 207 segments, MaRIA>7 and Clermont score>8...
August 31, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28918484/drug-herb-interactions-in-the-elderly-patient-with-ibd-a-growing-concern
#11
REVIEW
Haider Rahman, Marina Kim, Galen Leung, Jesse A Green, Seymour Katz
Inflammatory bowel disease (IBD), which includes conditions such as Crohn's disease and ulcerative colitis, is becoming more prevalent with the elderly being the fastest growing group. Parallel to this, there is an increasing interest in the use of complementary and alternative medicine (CAM). Nearly half of patients with IBD have used CAM at one time. The elderly patients, however, are burdened by comorbid conditions, polypharmacy, and altered functional status. With increasing use of complementary and alternative medicine in our elderly patients with IBD, it is vital for the provider to provide counsel on drug-herb potential interactions...
September 16, 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28917455/use-of-capsule-endoscopy-to-identify-lesions-suggestive-of-crohn-s-disease-in-patients-with-moderate-to-severe-psoriasis
#12
Robert Bissonnette, Raja Tamaz, Chantal Bolduc, Catherine Maari, Caroline Robillard, Simon Nigen, Isabelle Delorme, Charles Lynde
No abstract text is available yet for this article.
October 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28917233/high-prevalence-of-vitamin-b-12-insufficiency-in-patients-with-crohn-s-disease
#13
Misora Ao, Hidemi Tsuji, Kenichiro Shide, Yuki Kosaka, Akari Noda, Nobuya Inagaki, Hiroshi Nakase, Kiyoshi Tanaka
BACKGROUND AND OBJECTIVES: In Crohn's disease (CD), belonging to inflammatory bowel disease, the small intestine is involved in most cases. Most frequently affected is the distal ileum, where vitamin B-12 is specifically absorbed. Therefore, malabsorption of vitamin B-12 is quite likely to occur in patients with CD. In this study, we have studied the vitamin B-12 status in CD patients. METHODS AND STUDY DESIGN: Forty eight patients with CD were evaluated for their food intake, and circulating concentrations of vitamin B-12, folic acid, and homocysteine (Hcy) as a sensitive marker for the insufficiency of these vitamins and a risk factor of atherosclerosis...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28917218/erythema-elevatum-diutinum-in-crohn-s-disease-associated-spondyloarthritis-a-rare-vasculitis-an-unusual-association
#14
Maria João Gonçalves, Vasco C Romão, Luís Soares-de-Almeida, Helena Canhão, José Carlos Romeu, Heinz Kutzner, José Alberto Pereira-da-Silva
Erythema elevatum diutinum is a rare neutrophilic dermatoses with vasculitis, which presents as persistent, symmetrical, purple or brownish papules and nodules, mainly in the extensor surface of the limbs. We describe a case of erythema elevatum diutinum and polyarthritis as initial manifestations of Crohn's disease associated spondyloarthritis. A 51-year-old man, from São Tomé e Príncipe, with previous history of treated tuberculosis and chronic hepatitis B infection, was admitted due to 4 months history of polyarthritis, hyperpigmented papules on the extensor surfaces, occasional episodes of bloody mucous diarrhea and significant weight loss...
September 14, 2017: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/28915953/syntrophic-imbalance-and-the-etiology-of-bacterial-endoparasitism-diseases
#15
James F White
This article outlines the proposed 'syntrophic imbalance hypothesis' for etiology of bacterial endoparasitism diseases. This hypothesis involves microbes (archaea and bacteria) that exist in human body biofilms in syntrophic associations, where bacteria ferment nutrients to produce short chain fatty acids (SCFAs) that are used by methanogenic archaeons to produce methane. Overgrowth of archaea on human tissues (e.g., in association with intestines, teeth or lungs) results in excessive removal of SCFAs from the biofilms and this triggers bacteria in the free-living biofilm state to convert to the endoparasitic state and become intracellular in host cells where they incite inflammation and disease...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28915891/inflammatory-bowel-disease-specific-health-related-quality-of-life-instruments-a-systematic-review-of-measurement-properties
#16
REVIEW
Xin-Lin Chen, Liang-Huan Zhong, Yi Wen, Tian-Wen Liu, Xiao-Ying Li, Zheng-Kun Hou, Yue Hu, Chuan-Wei Mo, Feng-Bin Liu
BACKGROUND: This review aims to critically appraise and compare the measurement properties of inflammatory bowel disease (IBD)-specific health-related quality of life instruments. METHODS: Medline, EMBASE and ISI Web of Knowledge were searched from their inception to May 2016. IBD-specific instruments for patients with Crohn's disease, ulcerative colitis or IBD were enrolled. The basic characteristics and domains of the instruments were collected. The methodological quality of measurement properties and measurement properties of the instruments were assessed...
September 15, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28914579/a-polymicrobial-view-of-disease-potential-in-crohn-s-associated-adherent-invasive-e-coli
#17
Wael Elhenawy, Alexander Oberc, Brian K Coombes
The human gut is home to trillions of bacteria and provides the scaffold for one of the most complex microbial ecosystems in nature. Inflammatory bowel diseases, such as Crohn's disease, involve a compositional shift in the microbial constituents of this ecosystem with a marked expansion of Enterobacteriaceae, particularly Escherichia coli. Adherent-invasive E. coli (AIEC) strains are frequently isolated from the biopsies of Crohn's patients, where their ability to elicit inflammation suggests a possible role in Crohn's pathology...
September 15, 2017: Gut Microbes
https://www.readbyqxmd.com/read/28914206/mesenchymal-stem-cell-as-a-potential-therapeutic-for-inflammatory-bowel-disease-myth-or-reality
#18
Sanjucta Adak, Sayani Mukherjee, Dwaipayan Sen
BACKGROUND: Inflammatory bowel diseases (IBD), which include Crohn&#039;s disease and Ulcerative Colitis, are inflammatory autoimmune diseases which severely affect the quality of life. Till date, no long-lasting cure has been found for the disease and all the current treatment strategies are mainly focused on dampening the symptomatic inflammatory process that has certain side effects. In addition, a large number of patients remain refractory to conventional therapies. Mesenchymal stem cells (MSCs) can be looked upon as a biodrug to treat IBD owing to their immune-suppressive and regenerative capabilities...
September 13, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28913968/risk-factors-for-unfavourable-postoperative-outcome-in-patients-with-crohn-s-disease-undergoing-right-hemicolectomy-or-ileocaecal-resection-an-international-audit-by-escp-and-s-ecco
#19
(no author information available yet)
BACKGROUND: Patient and disease-related factors, as well as operation technique all have the potential to impact on postoperative outcome in Crohn's disease. The available evidence is based on small series and often displays conflicting results. AIM: To investigate the effect of pre- and intra-operative risk factors on 30-day postoperative outcome in patients undergoing surgery for Crohn's disease. METHOD: International prospective snapshot audit including consecutive patients undergoing right hemicolectomy or ileocaecal resection...
September 15, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28912620/hormonal-contraception-and-the-development-of-autoimmunity-a-review-of-the-literature
#20
William V Williams
Estrogens and progestins are known to have profound effects on the immune system and may modulate the susceptibility to autoimmune diseases. A comprehensive literature search was carried out using PubMed for any of 153 autoimmune disease terms and the terms contraception, contraceptive, or their chemical components with limits of Humans + Title or Abstract. Over 1,800 titles were returned and scanned, 352 papers retrieved and reviewed in depth and an additional 70 papers retrieved from the bibliographies. Based on this review, substantial evidence exists linking the use of combined oral contraceptives to a lower incidence of hyperthyroidism, an increase in multiple sclerosis, ulcerative colitis, Crohn's disease, Systemic Lupus Erythematosus, and interstitial cystitis...
August 2017: Linacre Quarterly
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