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https://www.readbyqxmd.com/read/29693275/the-effect-of-cd26-deficiency-on-dipeptidyl-peptidase-8-and-9-expression-profiles-in-a-mouse-model-of-crohn-s-disease
#1
Suncica Buljevic, Dijana Detel, Ester P Pugel, Jadranka Varljen
The involvement of dipeptidyl peptidase (DP) IV/CD26 (DPP IV/CD26) family members in the pathogenesis of Crohn's disease (CD), an autoimmune inflammatory condition of the gut, is effected mainly through proteolytic cleavage of immunomodulatory substrates and DPP IV/CD26's costimulatory function. DP8 and DP9 are proteases with diverse functions including cell interactions, apoptosis, and immune response but their localization remains to be clarified. We assessed the impact of DPP IV/CD26 deficiency (CD26-/- ) on the expression profiles of DP8 and DP9 by qPCR and immunodetection as well as quantified DP8/9 enzyme activity in distinctive phases of a chemically-induced CD model in mice...
April 25, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29693066/squamous-cell-carcinoma-arising-in-a-chronic-perineal-wound-in-a-patient-with-long-standing-cutaneous-crohn-s-disease
#2
Helen B Powell, Paul B Googe, Christopher J Sayed
No abstract text is available yet for this article.
May 2018: JAAD Case Reports
https://www.readbyqxmd.com/read/29692798/the-presence-of-genotoxic-and-or-pro-inflammatory-bacterial-genes-in-gut-metagenomic-databases-and-their-possible-link-with-inflammatory-bowel-diseases
#3
Abiel Roche-Lima, Kelvin Carrasquillo-Carrión, Ramón Gómez-Moreno, Juan M Cruz, Dayanara M Velázquez-Morales, Igor B Rogozin, Abel Baerga-Ortiz
Background: The human gut microbiota is a dynamic community of microorganisms that mediate important biochemical processes. Differences in the gut microbial composition have been associated with inflammatory bowel diseases (IBD) and other intestinal disorders. In this study, we quantified and compared the frequencies of eight genotoxic and/or pro-inflammatory bacterial genes found in metagenomic Whole Genome Sequences (mWGSs) of samples from individuals with IBD vs. a cohort of healthy human subjects. Methods: The eight selected gene sequences were clbN, clbB, cif, cnf-1, usp, tcpC from Escherichia coli, gelE from Enterococcus faecalis and murB from Akkermansia muciniphila ...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29692785/the-selective-autophagy-receptor-optineurin-in-crohn-s-disease
#4
REVIEW
Markus Tschurtschenthaler, Timon Erik Adolph
Autophagy is a pathway that allows cells to target organelles, protein complexes, or invading microorganisms for lysosomal degradation. The specificity of autophagic processes is becoming increasingly recognized and is conferred by selective autophagy receptors such as Optineurin (OPTN). As an autophagy receptor, OPTN controls the clearance of Salmonella infection and mediates mitochondrial turnover. Recent studies demonstrated that OPTN is critically required for pathogen clearance and an appropriate cytokine response in macrophages...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29692603/inflammatory-bowel-disease-patients-prioritize-mucosal-healing-symptom-control-and-pain-when-choosing-therapies-results-of-a-prospective-cross-sectional-willingness-to-pay-study
#5
James C Gregor, Martin Williamson, Dorota Dajnowiec, Bernie Sattin, Erik Sabot, Baljinder Salh
Background: Given the large armamentarium of therapies for inflammatory bowel disease (IBD), physicians cannot fully describe all treatments to patients and, therefore, make assumptions regarding treatment attributes communicated to patients. This study aimed to assess out-of-pocket willingness-to-pay that IBD patients allocate to treatment attributes. Methods: Adult patients receiving therapy for IBD were invited to access a cross-sectional web-based discrete-choice experiment (May 22-August 31, 2015) that presented paired medication scenarios with varying efficacy, safety, and administration parameters...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29692532/emphysematous-osteomyelitis-report-of-two-cases-and-review-of-literature
#6
Sachin Khanduri, Meenu Singh, Aakshit Goyal, Simran Singh
Emphysematous osteomyelitis is a rare condition characterized by the presence of intraosseous gas. A prompt diagnosis is required for this disease to expedite management as it is a potentially fatal condition. Many comorbidities, such as malignancy, diabetes mellitus, alcohol abuse, Crohn's disease, and other etiologies causing immunosuppression, predispose to this condition. The causative organisms are generally anaerobes or members of Enterobacteriaceae family; however, the infection can be mono or polymicrobial...
January 2018: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/29688902/crohn-s-disease-and-pemphigus-is-there-an-association-a-population-based-study
#7
Khalaf Kridin, Doron Comaneshter, Arnon D Cohen
BACKGROUND: Although the coexistence of Crohn's disease (CD) and pemphigus has been reported in several individuals, the association between the two conditions was not investigated systematically in the past. A recent association between pemphigus and ulcerative colitis has been reported. The study aims to estimate the association between pemphigus and CD using a large-scale real-life computerized database. PATIENTS AND METHODS: A cross-sectional study was carried out comparing pemphigus patients with age-matched, sex-matched, and ethnicity-matched control participants in terms of the prevalence of CD...
April 23, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29688802/infliximab-restores-colonic-barrier-to-adherent-invasive-e-coli-in-crohn-s-disease-via-effects-on-epithelial-lipid-rafts
#8
Olena Yakymenko, Ida Schoultz, Elisabeth Gullberg, Magnus Ström, Sven Almer, Conny Wallon, Arthur Wang, Åsa V Keita, Barry J Campbell, Derek M McKay, Johan D Söderholm
OBJECTIVE: Infliximab is important in the therapeutic arsenal of Crohn's disease (CD). However, its effect on mucosal barrier function is not fully understood. Adherent-invasive Escherichia coli (AIEC) are important in CD pathophysiology, but the transmucosal uptake routes are partly unknown. We investigated effects of infliximab on uptake of colon-specific AIEC HM427 across CD colonic mucosa. MATERIALS AND METHODS: Endoscopic biopsies from non-inflamed colon of seven patients with CD, before and after two infliximab infusions, and eight non-inflammation controls, were mounted in Ussing chambers...
April 24, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29688479/ustekinumab-treatment-in-crohn-s-disease-of-barnett-continent-intestinal-reservoir
#9
Freeha Khan, Bo Shen
No abstract text is available yet for this article.
April 23, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29688478/agreement-between-crohn-s-disease-endoscopic-severity-scores-derived-from-live-video-recorded-and-central-readings
#10
Justin Côté-Daigneault, Farhad Peerani, Konstantinos Katsanos, Thomas Ullman, James Marion, Peter Legnani, Benjamin Cohen, Jean-Frédéric Colombel
No abstract text is available yet for this article.
April 23, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29688473/detection-of-gut-dysbiosis-due-to-reduced-clostridium-subcluster-xiva-using-the-fecal-or-serum-bile-acid-profile
#11
Masashi Murakami, Junichi Iwamoto, Akira Honda, Takeshi Tsuji, Makoto Tamamushi, Hajime Ueda, Tadakuni Monma, Naoki Konishi, Shoichiro Yara, Takeshi Hirayama, Teruo Miyazaki, Yoshifumi Saito, Tadashi Ikegami, Yasushi Matsuzaki
Background: Dysbiosis, especially a reduced Clostridium subcluster XIVa (XIVa), has been reported in several gastrointestinal diseases. Since XIVa is thought to be the main bacterial cluster that metabolizes bile acids (BAs) in the human intestine, we hypothesized that the BA profile in feces, and possibly in serum, could be a convenient biomarker for intestinal XIVa activity. Methods: First, blood and feces were collected from 26 healthy controls and 20 patients with gastrointestinal diseases, and the relationships among fecal microbiomes and fecal and serum BA compositions were studied...
April 23, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29688472/management-of-pouchitis-and-other-common-complications-of-the-pouch
#12
Robin L Dalal, Bo Shen, David A Schwartz
Restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) has become the preferred surgical treatment for refractory or complicated ulcerative colitis (UC) and familial adenomatous polyposis (FAP). Pouchitis is the most common complication of this procedure and can occur in about 50% of patients. Treatment of pouchitis depends on the phenotype of disease. Pouchitis can be classified as acute, chronic/refractory, or secondary pouchitis, which includes pouchitis occurring due to Crohn's disease (CD)...
April 23, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29688470/diagnostic-accuracy-of-ultrasonography-in-the-detection-of-postsurgical-recurrence-in-crohn-s-disease-a-systematic-review-with-meta-analysis
#13
Antonio Rispo, Nicola Imperatore, Anna Testa, Olga Maria Nardone, Gaetano Luglio, Nicola Caporaso, Fabiana Castiglione
Background and aims: The postoperative course of Crohn's disease (CD) is best predicted by ileocolonoscopy. Ultrasonography (US) has been proposed as indicator for postsurgical recurrence (PSR), but further confirmation is needed. We performed a systemic review with meta-analysis to assess the pooled diagnostic accuracy of US in the evaluation of PSR. Methods: The systematic review was performed in PubMed/MEDLINE, EMBASE, SCOPUS, and Cochrane databases to identify studies assessing the US accuracy in PSR diagnosis...
April 23, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29688467/crohn-s-colitis-foundation-engaging-ibd-patients-for-50-years
#14
(no author information available yet)
No abstract text is available yet for this article.
April 23, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29688466/quality-of-life-in-inflammatory-bowel-disease-a-systematic-review-and-meta-analyses-part-ii
#15
Simon R Knowles, Laurie Keefer, Helen Wilding, Catherine Hewitt, Lesley A Graff, Antonina Mikocka-Walus
Background: There has been burgeoning interest in quality of life (QoL) in inflammatory bowel disease (IBD) in recent decades, with hundreds of studies each year now assessing this outcome. This paper is part 2 of a systematic review evaluating 5 key QoL comparisons within IBD states and relative to others without IBD. Part 1 examined QoL comparing IBD and a healthy/general population and other medically ill groups. Part 2, presented here, examines within-disease comparisons of active/inactive disease, Ulcerative colitis (UC) / Crohn's disease (CD), and change in QoL over time...
April 23, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29688465/low-incidence-of-dysplasia-and-colorectal-cancer-observed-among-inflammatory-bowel-disease-patients-with-prolonged-colonic-diversion
#16
Weston Bettner, Anthony Rizzo, Steven Brant, Sharon Dudley-Brown, Jonathan Efron, Sandy Fang, Susan Gearhart, Michael Marohn, Alyssa Parian, Maryam Kherad Pezhouh, Joanna Melia, Bashar Safar, Brindusa Truta, Elizabeth Wick, Mark Lazarev
Background: In inflammatory bowel disease (IBD), many scenarios call for fecal diversion, leaving behind defunctionalized bowel. The theoretical risk of colorectal cancer (CRC) in this segment is frequently cited as a reason for resection. To date, no studies have characterized the incidence of neoplasia in the diverted colorectal segments of IBD patients. Methods: A retrospective cohort analysis was conducted for IBD patients identified through a tertiary care center pathology database...
April 23, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29688464/smoking-interacts-with-chrna5-a-nicotinic-acetylcholine-receptor-subunit-gene-to-influence-the-risk-of-ibd-related-surgery
#17
Kelly C Cushing, Adeeti Chiplunker, Allie Li, Yun Ju Sung, Taylor Geisman, Li-Shiun Chen, Sharon Cresci, Alexandra M Gutierrez
Background: Inflammatory bowel disease (IBD) is a chronic luminal disease with genetic and environmental factors affecting phenotype. This study evaluated the relationship between CHRNA5, a nicotinic receptor subunit gene, and smoking in predicting IBD-related surgery as well as the relationship between CHRNA5 and nicotine dependence. Methods: Participants completed a smoking questionnaire and were genotyped for CHRNA5 rs16969968. Demographic and clinical data were obtained from medical records...
April 23, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29688413/sex-related-differences-in-patients-with-inflammatory-bowel-disease-results-of-2-prospective-cohort-studies
#18
Mirjam Severs, Lieke M Spekhorst, Marie-Josée J Mangen, Gerard Dijkstra, Mark Löwenberg, Frank Hoentjen, Andrea E van der Meulen-de Jong, Marieke Pierik, Cyriel Y Ponsioen, Gerd Bouma, Janneke C van der Woude, Mirthe E van der Valk, Marielle J L Romberg-Camps, Cees H M Clemens, Paul van de Meeberg, Nofel Mahmmod, Jeroen Jansen, Bindia Jharap, Rinse K Weersma, Bas Oldenburg, Eleonora A M Festen, Herma H Fidder
Background: The understanding of gender differences in inflammatory bowel disease (IBD) patients is an important step towards tailored treatment for the individual patient. The aim of this study was to compare disease phenotype, clinical manifestations, disease activity, and healthcare utilization between men and women with Crohn's disease (CD) and ulcerative colitis (UC). Methods: Two multicenter observational cohort studies with a prospective design were used to explore the differences between men and women regarding demographic and phenotypic characteristics and healthcare utilization...
April 21, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29688409/methotrexate-for-the-treatment-of-pediatric-crohn-s-disease-a-systematic-review-and-meta-analysis
#19
Ruben J Colman, Rachel C Lawton, Marla C Dubinsky, David T Rubin
Background: Methotrexate (MTX) is an immunomodulator used for the treatment of pediatric inflammatory bowel disease (IBD). There are currently no RCTs that assess the treatment efficacy of methotrexate within the pediatric IBD patient population. This systematic review and meta-analysis assesses the efficacy of MTX therapy among the existing pediatric literature. Methods: A systematic literature search was performed using MEDLINE and the Cochrane library from inception until March 2016...
April 23, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29688401/anal-fistulas-in-severe-perineal-crohn-s-disease-mri-assessment-in-the-determination-of-long-term-healing-rates
#20
Charlène Brochard, Amandine Landemaine, Alexandre Merlini L'Heritier, Marie Provost Dewitte, Belinda Tchoundjeu, Tanguy Rohou, Aurélien Garros, Guillaume Bouguen, Laurent Siproudhis
Background & Aims: The European Crohn's and Colitis Organization recommends magnetic resonance imaging (MRI) of anal fistulas to decide on the drug/surgery strategy. No evidence is available on the long-term impact of MRI features on fistula healing. The aim of this study was to evaluate the benefit of combined drug/surgery strategies for the treatment of perianal Crohn's fistulas based on MRI factors at referral. Methods: The clinical event (anal abscess, new fistula tract, cellulitis), therapeutic intervention (introduction/optimization of immunosuppressant/biologics, anal surgery, intestinal resection, stoma), and MRI data were prospectively recorded for patients with Crohn's disease (CD) and anal fistulas...
April 20, 2018: Inflammatory Bowel Diseases
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