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https://www.readbyqxmd.com/read/26713362/modified-sympathetic-nerve-regulation-in-akap5-null-mice
#1
Chong Han, Hirofumi Tomita, Takayoshi Ohba, Kimitaka Nishizaki, Yoshiki Ogata, Yasushi Matsuzaki, Daisuke Sawamura, Teruyuki Yanagisawa, Tomohiro Osanai, Tadaatsu Imaizumi, Atsushi Matsubara, Takeshi Adachi, Kyoichi Ono, Ken Okumura, Manabu Murakami
Genetic analyses have revealed an important association between A-kinase anchoring proteins (AKAPs) and the intracellular calcium modulating system. AKAP5, also known as AKAP79/150, is an anchoring protein between PKA and voltage-dependent calcium channels, ryanodine receptor-2, phospholamban and other molecules. The aim of the present study was to elucidate the physiological importance of AKAP5 in the creation of cardiac rhythm using AKAP5-null mice. ECG analysis showed a normal sinus rhythm and a decreased responsiveness to isoproterenol in AKAP5-null mice compared with wild-type mice...
January 22, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/25789584/akap5-signaling-complexes-focal-points-and-functional-properties
#2
REVIEW
Yanjing Guo, Tao Bo, Xinli Zhou, Ling Gao, Yong Wang, Jiajun Zhao
Kinase Anchoring Proteins (AKAPs) have evolved to regulate the spatial and temporal organization of cellular signal transduction. As a typical member, AKAP5 which consisting of three orthologues: bovine AKAP75, rodent AKAP150 and human AKAP79, is the best known model in the anchoring and targeting properties. It is shown that AKAP5 can bind β2-adrenergic receptor, which is a member of GPCR superfamily, and orchestrate the interactions of various protein kinases, protein phosphatases and cytoskeletal element...
2015: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/24121510/role-of-akap79-150-protein-in-%C3%AE-1-adrenergic-receptor-trafficking-and-signaling-in-mammalian-cells
#3
Xin Li, Mohammed M Nooh, Suleiman W Bahouth
Protein kinase A-anchoring proteins (AKAPs) participate in the formation of macromolecular signaling complexes that include protein kinases, ion channels, effector enzymes, and G-protein-coupled receptors. We examined the role of AKAP79/150 (AKAP5) in trafficking and signaling of the β1-adrenergic receptor (β1-AR). shRNA-mediated down-regulation of AKAP5 in HEK-293 cells inhibited the recycling of the β1-AR. Recycling of the β1-AR in AKAP5 knockdown cells was rescued by shRNA-resistant AKAP5. However, truncated mutants of AKAP5 with deletions in the domains involved in membrane targeting or in binding to calcineurin or PKA failed to restore the recycling of the β1-AR, indicating that full-length AKAP5 was required...
November 22, 2013: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/23649627/adenylyl-cyclase-anchoring-by-a-kinase-anchor-protein-akap5-akap79-150-is-important-for-postsynaptic-%C3%AE-adrenergic-signaling
#4
Mingxu Zhang, Tommaso Patriarchi, Ivar S Stein, Hai Qian, Lucas Matt, Minh Nguyen, Yang K Xiang, Johannes W Hell
Recent evidence indicates that the A kinase anchor protein AKAP5 (AKAP79/150) interacts not only with PKA but also with various adenylyl cyclase (AC) isoforms. However, the physiological relevance of AC-AKAP5 binding is largely unexplored. We now show that postsynaptic targeting of AC by AKAP5 is important for phosphorylation of the AMPA-type glutamate receptor subunit GluA1 on Ser-845 by PKA and for synaptic plasticity. Phosphorylation of GluA1 on Ser-845 is strongly reduced (by 70%) under basal conditions in AKAP5 KO mice but not at all in D36 mice, in which the PKA binding site of AKAP5 (i...
June 14, 2013: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/21554706/akap5-and-akap12-form-homo-oligomers
#5
Shujuan Gao, Hsien-Yu Wang, Craig C Malbon
BACKGROUND: A-kinase-anchoring proteins, AKAPs, constitute a family of scaffolds that play an essential role in catalyzing the spatial-temporal, dynamic interactions of protein kinase A, protein kinase C, tyrosine kinases, G-protein-coupled receptors and ion channels. We studied AKAP5 (AKAP79; MW ~47 kDa) and AKAP12 (gravin, SSECKS; MW ~191 kDa) to probe if these AKAP scaffolds oligomerize. RESULTS: In gel analysis and sodium-dodecyl sulfate denaturation, AKAP12 behaved with a MW of a homo-dimer...
May 9, 2011: Journal of Molecular Signaling
https://www.readbyqxmd.com/read/21490206/akap-signaling-in-reinstated-cocaine-seeking-revealed-by-itraq-proteomic-analysis
#6
Kathryn J Reissner, Joachim D Uys, John H Schwacke, Susanna Comte-Walters, Jennifer L Rutherford-Bethard, Thomas E Dunn, Joe B Blumer, Kevin L Schey, Peter W Kalivas
To identify candidate proteins in the nucleus accumbens (NAc) as potential pharmacotherapeutic targets for treating cocaine addition, an 8-plex iTRAQ (isobaric tag for relative and absolute quantitation) proteomic screen was performed using NAc tissue obtained from rats trained to self-administer cocaine followed by extinction training. Compared with yoked-saline controls, 42 proteins in a postsynaptic density (PSD)-enriched subfraction of the NAc from cocaine-trained animals were identified as significantly changed...
April 13, 2011: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/20428246/mutations-in-akap5-disrupt-dendritic-signaling-complexes-and-lead-to-electrophysiological-and-behavioral-phenotypes-in-mice
#7
Michael Weisenhaus, Margaret L Allen, Linghai Yang, Yuan Lu, C Blake Nichols, Thomas Su, Johannes W Hell, G Stanley McKnight
AKAP5 (also referred to as AKAP150 in rodents and AKAP79 in humans) is a scaffolding protein that is highly expressed in neurons and targets a variety of signaling molecules to dendritic membranes. AKAP5 interacts with PKA holoenzymes containing RIIalpha or RIIbeta as well as calcineurin (PP2B), PKC, calmodulin, adenylyl cyclase type V/VI, L-type calcium channels, and beta-adrenergic receptors. AKAP5 has also been shown to interact with members of the MAGUK family of PSD-scaffolding proteins including PSD95 and SAP97 and target signaling molecules to receptors and ion channels in the postsynaptic density (PSD)...
April 23, 2010: PloS One
https://www.readbyqxmd.com/read/16442664/g-protein-coupled-receptor-associated-a-kinase-anchoring-proteins-akap79-and-akap250-gravin
#8
REVIEW
Hsien-Yu Wang, Jiangchuan Tao, Elena Shumay, Craig C Malbon
A-kinase anchoring proteins (AKAPs) define an expanding group of scaffold proteins that display a signature binding site for the RI/RII subunit of protein kinase A. AKAPs are multivalent and a subset of these scaffold proteins also display the ability to associate with the prototypic member of G-protein-coupled receptors, the beta(2)-adrenergic receptor. Both AKAP79 (also known as AKAP5) and AKAP250 (also known as gravin or AKAP12) have been shown to associate with the beta(2)-adrenergic receptor, but each directs downstream signaling events in decidedly different manners...
July 2006: European Journal of Cell Biology
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