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https://www.readbyqxmd.com/read/28654760/gametocidal-genes-of-aegilops-segregation-distorters-in-wheat-aegilops-wide-hybridization
#1
M Niranjana
Aegilops is a genus belonging to the Poaceace family which have played indispensible role in the evolution of bread wheat and continues to do so by transferring genes by wide hybridization. Being the secondary genepool of wheat, gene transfer from Aegilops poses difficulties and segregation distortion is common. Gametocidal genes are the most well characterized class of segregation distorters reported in interspecific crosses of wheat with Aegilops. These are selfish genetic elements which ensure their preferential transmission to progeny at the cost of gametes lacking them without providing any phenotypic benefits to the plant causing a proportional reduction in fertility...
June 27, 2017: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/28654752/in-silico-prediction-of-the-toxic-potential-of-lupeol
#2
Manuel Antonio Ruiz-Rodríguez, Angelo Vedani, Ana Lidia Flores-Mireles, Manuel Humberto Chairez-Ramirez, Jose Alberto Gallegos-Infante, Ruben F Gonzalez-Laredo
Lupeol is a natural triterpenoid found in many plant species such as mango. This compound is the principal active component of many traditional herbal medicines. In the past decade, a considerable number of publications dealt with lupeol and its analogues due to the interest in their pharmacological activities against cancer, inflammation, arthritis, diabetes, and heart disease. To identify further potential applications of lupeol and its analogues, it is necessary to investigate their mechanisms of action, particularly, their interaction with off-target proteins that may trigger adverse effects or toxicity...
June 27, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28654070/generation-of-genetically-modified-mice-through-the-microinjection-of-oocytes
#3
Fabien Delerue, Lars M Ittner
The use of genetically modified mice has significantly contributed to studies on both physiological and pathological in vivo processes. The pronuclear injection of DNA expression constructs into fertilized oocytes remains the most commonly used technique to generate transgenic mice for overexpression. With the introduction of CRISPR technology for gene targeting, pronuclear injection into fertilized oocytes has been extended to the generation of both knockout and knockin mice. This work describes the preparation of DNA for injection and the generation of CRISPR guides for gene targeting, with a particular emphasis on quality control...
June 15, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28653969/changes-in-fertility-at-the-population-level-in-the-era-of-art-in-rural-malawi
#4
Estelle McLean, Alison Price, Menard Chihana, Ndoliwe Kayuni, Milly Marston, Olivier Koole, Basia Zaba, Amelia Crampin
INTRODUCTION: HIV reduces fertility through biological and social pathways, and antiretroviral treatment (ART) can ameliorate these effects. In northern Malawi, ART has been available since 2007 and lifelong ART is offered to all pregnant or breastfeeding HIV-positive women. METHODS: Using data from the Karonga Health and Demographic Surveillance Site in Malawi from 2005 to 2014, we used total and age-specific fertility rates and Cox regression to assess associations between HIV and ART use and fertility...
August 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28653894/molecular-and-clinical-attributes-of-uterine-leiomyomas
#5
Dana Dvorská, Dušan Braný, Zuzana Danková, Erika Halašová, Jozef Višňovský
Uterine leiomyomas, also called uterine fibroids or myomas, represent one of the most common benign tumour types in women of a fertile age. Leiomyomas arise due to transformation of the layer of smooth muscle cells of corpus uteri - the myometrium. Despite frequent occurrence of this disease, the molecular mechanisms behind the origin and development of leiomyomas are still relatively unknown. Most predisposed are obese women and women of African origin. In more than half of cases, leiomyomas remain asymptomatic...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28653619/semen-amyloids-participate-in-spermatozoa-selection-and-clearance
#6
Nadia R Roan, Nathallie Sandi-Monroy, Nargis Kohgadai, Shariq M Usmani, Katherine G Hamil, Jason Neidleman, Mauricio Montano, Ludger Ständker, Annika Röcker, Marielle Cavrois, Jared Rosen, Kara Marson, James F Smith, Christopher D Pilcher, Friedrich Gagsteiger, Olena Sakk, Michael O'Rand, Polina V Lishko, Frank Kirchhoff, Jan Münch, Warner C Greene
Unlike other human biological fluids, semen contains multiple types of amyloid fibrils in the absence of disease. These fibrils enhance HIV infection by promoting viral fusion to cellular targets, but their natural function remained unknown. The similarities shared between HIV fusion to host cell and sperm fusion to oocyte led us to examine whether these fibrils promote fertilization. Surprisingly, the fibrils inhibited fertilization by immobilizing sperm. Interestingly, however, this immobilization facilitated uptake and clearance of sperm by macrophages, which are known to infiltrate the female reproductive tract (FRT) following semen exposure...
June 27, 2017: ELife
https://www.readbyqxmd.com/read/28653449/the-value-of-biomarkers-in-bone-metastasis
#7
Stella D'Oronzo, Janet Brown, Robert Coleman
The worst complication of cancer is represented by its spread to distant sites. In particular, bone provides a fertile soil for several cancer types, especially those derived from breast, prostate and lung tumours. Despite the progress in diagnostic and therapeutic strategies, bone metastases (BM) still impact on quality of life and overall survival, making it necessary to identify the "high-risk" patients at an earlier stage. Since BM affect physiological bone turnover, measurement of bone turnover markers (BTM) has been widely investigated for diagnostic and prognostic purposes, as well as to support the development of anti-cancer drugs...
June 27, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28653338/a-method-for-detailed-movement-pattern-analysis-of-tadpole-startle-response
#8
Kasra Zarei, Karen L Elliott, Sanam Zarei, Bernd Fritzsch, James H J Buchholz
Prolonged space flight, specifically microgravity, presents a problem for space exploration. Animal models with altered connections of the vestibular ear, and thus altered gravity sensation, would allow the examination of the effects of microgravity and how various countermeasures can establish normal function. We describe an experimental apparatus to monitor the effects of ear manipulations to generate asymmetric gravity input on the tadpole escape response. To perform the movement pattern analysis, an imaging apparatus was developed that uses a high-speed camera to obtain time-resolved, high-resolution images of tadpole movements...
June 27, 2017: Journal of the Experimental Analysis of Behavior
https://www.readbyqxmd.com/read/28652905/retrospective-analysis-of-endemic-melasma-patients
#9
Serkan Demirkan, Özgür Gündüz, Cemile Dayangan Sayan
Melasma is an acquired diffuse hypermelanosis characterized by localized, symmetrical, irregular, light-to-dark brown maculae occurring in sun-exposed areas of skin. The aim of this retrospective study was to determine demographics of patients, analysis of etiologic factors, clinical features, efficacy and side effects of available topical treatments due to high incidence of melasma patients. In this study melasma patients in Birecik State Hospital were investigated retrospectively. Between January 2014 and October 2015, 1008 patients had diagnosis of melasma in 49,809 applications of 24,603 different patients who admitted to Dermatology Outpatient Clinics...
March 13, 2017: Dermatology Reports
https://www.readbyqxmd.com/read/28652594/self-diploidization-of-human-haploid-parthenogenetic-embryos-through-the-rho-pathway-regulates-endomitosis-and-failed-cytokinesis
#10
Lizhi Leng, Qi Ouyang, Xiangyi Kong, Fei Gong, Changfu Lu, Lei Zhao, Yun Shi, Dehua Cheng, Liang Hu, Guangxiu Lu, Ge Lin
A diploid genome is necessary for normal mammalian development, thus haploid parthenogenetic embryos undergo frequent self-diploidization during preimplantation development; however, the underlying mechanism is unclear. In this study, time-lapse recording revealed that human haploid parthenotes (HPs) undergo self-diploidization via failed cytokinesis (FC) and endomitosis (EM). The frequencies of FC/EM were significantly higher in HPs than in normal fertilized embryos (26.3% vs. 1.6%, P < 0.01; 19.7% vs...
June 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28652549/an-evaluation-method-for-suppression-of-pathogenic-fusarium-oxysporum-by-soil-microorganisms-using-the-dilution-plate-technique
#11
Masahiro Mitsuboshi, Yuuzou Kioka, Katsunori Noguchi, Susumu Asakawa
Volume 31, No. 3, Page 307-313, 2016Page 310, Legend for Fig. 4 IncorrectFig. 4. Growth degree of Fusarium oxysporum f. sp. spinaciae for organic fertilizers at each dilution based on an estimation of the ellipse area (A) and extension length (B) of the colony. Cont, compound inorganic fertilizer; SBM, steamed bone meal; CDC, cow dung compost; MI, microbial inoculant. Values show mean of medians of degrees with SE (n=3). The ellipse area and extension length for control plates were 4,475 mm(2) and 36.5 mm, respectively...
2017: Microbes and Environments
https://www.readbyqxmd.com/read/28652099/influence-of-adjuvant-chemotherapy-on-anti-m%C3%A3-llerian-hormone-in-women-below-35-years-treated-for-early-breast-cancer
#12
Anne Perdrix, Mathilde Saint-Ghislain, Marie Degremont, Marion David, Zena Khaznadar, Agnès Loeb, Marianne Leheurteur, Frédéric Di Fiore, Florian Clatot
The impact of chemotherapy on fertility appears to be of essential importance for the youngest cancer survivors. The aim of this study was to assess plasma anti-Mullërian hormone (AMH) evolution, using an automated sensitive AMH immunoassay in women younger than 35 years old before and after treatment with adjuvant chemotherapy for early breast cancer. We selected 54 women aged less than 35 years old, at the time of breast cancer diagnosis, who received chemotherapy between 2008 and 2014, and with plasma samples collected from the diagnosis, to 1 year, 3 years and 5 years post-diagnosis...
June 15, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28652098/mutation-analysis-of-the-tubb8-gene-in-nine-infertile-women-with-oocyte-maturation-arrest
#13
Lingli Huang, Xianhong Tong, Lihua Luo, Shengxia Zheng, Rentao Jin, Yingyun Fu, Guixiang Zhou, Daojing Li, Yusheng Liu
Mutations in the tubulin beta 8 class VIII (TUBB8) gene have been proven to cause oocyte maturation arrest. The aim of this study was to describe newly discovered mutations in TUBB8 and to investigate the prevalence of TUBB8 mutations in our cohort. Nine women with oocyte maturation arrest and 100 fertile female controls were recruited. Sanger sequencing of the coding regions of TUBB8 revealed a heterozygous variant c.535G > A (p.V179M) in two unrelated affected individuals and a heterozygous variant c.5G > T (p...
June 13, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28651960/humid-versus-dry-incubator-a%C3%A2-prospective-randomized-controlled-trial
#14
Mohamed Fawzy, Mohamed Y AbdelRahman, Mohamed H Zidan, Faten F Abdel Hafez, Hazem Abdelghafar, Hesham Al-Inany, Mohamed A Bedaiwy
OBJECTIVE: To evaluate the efficacy of a dry versus humidified incubator on human embryo development ex vivo. DESIGN: Prospective, double-blind, randomized, controlled trial. SETTING: Private fertility centers. PATIENT(S): A total of 297 women undergoing in vitro fertilization randomized into two groups. INTERVENTION(S): From days 0 to day 5 or 6 of culture, intervention group embryos exposed to dry culture and control group embryos exposed to humidified culture...
June 23, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28651959/patients-with-endometriosis-have-aneuploidy-rates-equivalent-to-their-age-matched-peers-in-the-in%C3%A2-vitro-fertilization-population
#15
Caroline Juneau, Emily Kraus, Marie Werner, Jason Franasiak, Scott Morin, George Patounakis, Thomas Molinaro, Dominique de Ziegler, Richard T Scott
OBJECTIVE: To determine whether endometriosis ultimately results in an increased risk of embryonic aneuploidy. DESIGN: Retrospective cohort. SETTING: Infertility clinic. PATIENT(S): Patients participating in an in vitro fertilization (IVF) cycle from 2009-2015 using preimplantation genetic screening (PGS) who had endometriosis identified by surgical diagnosis or by ultrasound findings consistent with a persistent space-occupying disease whose sonographic appearance was consistent with endometriosis...
June 23, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28651958/conception-by-means-of-in%C3%A2-vitro-fertilization-is-not-associated-with-maternal-depressive-symptoms-during-pregnancy-or-postpartum
#16
Pietro Gambadauro, Stavros Iliadis, Emma Bränn, Alkistis Skalkidou
OBJECTIVE: To study whether conception by means of in vitro fertilization (IVF) is associated with maternal depressive symptoms during pregnancy or postpartum. DESIGN: Longitudinal observational study. SETTING: University hospital. PATIENT(S): A total of 3,283 women with singleton pregnancies receiving antenatal care and delivering in Uppsala from 2010 to 2015. INTERVENTION(S): A web-based self-administered structured questionnaire including sociodemographic, clinical and pregnancy-related items, and the Edinburgh Postnatal Depression Scale (EPDS) was delivered at 17 and 32 gestational weeks and at 6 weeks and 6 months postpartum...
June 23, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28651518/further-study-of-late-devonian-seed-plant-cosmosperma-polyloba-its-reconstruction-and-evolutionary-significance
#17
Le Liu, Deming Wang, Meicen Meng, Jinzhuang Xue
BACKGROUND: The earliest seed plants in the Late Devonian (Famennian) are abundant and well known. However, most of them lack information regarding the frond system and reconstruction. Cosmosperma polyloba represents the first Devonian ovule in China and East Asia, and its cupules, isolated synangiate pollen organs and pinnules have been studied in the preceding years. RESULTS: New fossils of Cosmosperma were obtained from the type locality, i.e. the Leigutai Member of the Wutong Formation in Fanwan Village, Changxing County, Zhejiang Province, South China...
June 26, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28651360/novel-reproductive-technologies-to-prevent-mitochondrial-disease
#18
Lyndsey Craven, Mao-Xing Tang, Gráinne S Gorman, Petra De Sutter, Björn Heindryckx
BACKGROUND: The use of nuclear transfer (NT) has been proposed as a novel reproductive treatment to overcome the transmission of maternally-inherited mitochondrial DNA (mtDNA) mutations. Pathogenic mutations in mtDNA can cause a wide-spectrum of life-limiting disorders, collectively known as mtDNA disease, for which there are currently few effective treatments and no known cures. The many unique features of mtDNA make genetic counselling challenging for women harbouring pathogenic mtDNA mutations but reproductive options that involve medical intervention are available that will minimize the risk of mtDNA disease in their offspring...
June 23, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28651331/il-1%C3%AE-up-regulates-star-and-progesterone-production-through-the-erk1-2-and-p38-mediated-creb-signaling-pathways-in-human-granulosa-lutein-cells
#19
Xuan Dang, Qinling Zhu, Yaqiong He, Yuan Wang, Yao Lu, Xiaoxue Li, Jia Qi, Hasiximuke Wu, Yun Sun
The pro-inflammatory cytokine interleukin-1β (IL-1β) may be involved in several ovulation-associated events, such as proteases synthesis, prostaglandin production and steroidogenesis in granulosa cells. However, the exact effect of IL-1β on progesterone synthesis in granulosa cells and the underlying mechanism remain unclear. By using cultured granulosa-lutein cells collected from women undergoing in vitro fertilization or intracytoplasmic sperm injection, we found that IL-1β up-regulated steroidogenic acute regulatory protein (StAR) expression and progesterone synthesis in granulosa-lutein cells, which was comparable with luteinizing hormone (LH) effect and could be abolished by an IL-1 receptor antagonist...
June 23, 2017: Endocrinology
https://www.readbyqxmd.com/read/28651210/associations-between-perfluorinated-alkyl-acids-in-blood-and-ovarian-follicular-fluid-and-ovarian-function-in-women-undergoing-assisted-reproductive-treatment
#20
Jessica A McCoy, Jacqueline T Bangma, Jessica L Reiner, John A Bowden, John Schnorr, Michael Slowey, Thomas O'Leary, Louis J Guillette, Benjamin B Parrott
Endocrine disrupting contaminants, in combination with other environmental variables, are associated with altered reproductive health. Assisted reproductive technology (ART) procedures offer valuable opportunities to explore the connections between environmental contaminants in the ovarian microenvironment and measures of fertility, including impaired responsiveness to gonadotropins. Here, we investigate an emerging class of environmental contaminants, the perfluorinated alkyl acids (PFAAs), to determine whether ovarian contaminant levels are associated with measures of ovarian responsiveness and fertility outcomes in a South Carolina population of women undergoing ART...
June 23, 2017: Science of the Total Environment
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