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Herpes zoster

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https://www.readbyqxmd.com/read/28443092/disarming-cellular-alarm-systems-manipulation-of-stress-induced-nkg2d-ligands-by-human-herpesviruses
#1
REVIEW
Dominik Schmiedel, Ofer Mandelboim
The coevolution of viruses and their hosts led to the repeated emergence of cellular alert signals and viral strategies to counteract them. The herpesvirus family of viruses displays the most sophisticated repertoire of immune escape mechanisms enabling infected cells to evade immune recognition and thereby maintain infection. The herpesvirus family consists of nine viruses that are capable of infecting humans: herpes simplex virus 1 and 2 (HSV-1, HSV-2), varicella zoster virus (VZV), Epstein-Barr virus (EBV), human cytomegalovirus (HCMV), roseoloviruses (HHV-6A, HHV-6B, and HHV-7), and Kaposi's-sarcoma-associated herpesvirus (KSHV)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28442806/study-of-clinical-profile-of-herpes-zoster-in-human-immunodeficiency-virus-positive-and-negative-patients-at-a-rural-based-tertiary-care-center-gujarat
#2
Rita V Vora, Gopikrishnan Anjaneyan, Rahul Krishna S Kota, Abhishek P Pilani, Nilofar G Diwan, Nidhi N Patel
BACKGROUND: Herpes zoster usually presents with typically grouped vesicles on erythematous base involving single dermatome with self-limiting nature in immunocompetent individuals while it may present in extensive form involving multiple dermatomes involvement or disseminated form in immunocompromised, especially in human immunodeficiency virus (HIV). AIMS AND OBJECTIVES: The aim of this study was to study the prevalence of HIV in patients of herpes zoster, to compare the clinical presentation of herpes zoster in HIV-infected and noninfected patient...
January 2017: Indian Journal of Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28441162/managing-herpes-zoster-in-older-adults-prescribing-considerations
#3
Linda Beuscher, Geri Reeves, Debbie Harrell
NPs must be aware of special prescribing considerations for medication safety when managing the care of older adults with herpes zoster. Age-related physiologic changes of the body impact the pharmacokinetics and pharmacodynamics of antiviral and pain medications and can lead to potential adverse events.
April 24, 2017: Nurse Practitioner
https://www.readbyqxmd.com/read/28440680/efficacy-and-safety-of-baricitinib-in-japanese-patients-with-active-rheumatoid-arthritis-a-52-week-randomized-single-blind-extension-study
#4
Yoshiya Tanaka, Taeko Ishii, Zhihong Cai, Douglas Schlichting, Terence Rooney, William Macias
OBJECTIVES: The objective of this study is to evaluate the efficacy and safety of long-term (64 weeks; 52-week extension of a 12-week study) baricitinib treatment in Japanese patients with active rheumatoid arthritis (RA) despite methotrexate therapy. METHODS: Patients (N = 145) with active RA were randomized to placebo, 1mg, 2mg, 4mg, or 8mg baricitinib for the first 12 weeks. During the 52-week extension period, patients on 4mg or 8mg baricitinib remained on the same dose and all other patients were re-randomized to 4mg or 8mg baricitinib...
April 25, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28439065/multidisciplinary-study-of-the-secondary-immune-response-in-grandparents-re-exposed-to-chickenpox
#5
B Ogunjimi, J Van den Bergh, P Meysman, S Heynderickx, K Bergs, H Jansen, E Leuridan, A Vorsters, H Goossens, K Laukens, N Cools, Viggo Van Tendeloo, N Hens, P Van Damme, Evelien Smits, Ph Beutels
Re-exposure to chickenpox may boost varicella-zoster virus (VZV) immunity in the elderly. This secondary immune response is hypothesized to confer protection against herpes zoster. We longitudinally sampled 36 adults over the course of one year after re-exposure to chickenpox. The resulting 183 samples and those of 14 controls were assessed for VZV-specific T-cell immunity and antibody titres. The percentages of VZV-specific CD4+ IL-2-producing T-cells were increased in re-exposed grandparents compared to control participants up to 9 months after re-exposure...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28438128/viral-aetiologies-of-acute-encephalitis-in-a-hospital-based-south-asian-population
#6
Janarthani Lohitharajah, Neelika Malavige, Carukshi Arambepola, Jithangi Wanigasinghe, Ranjanie Gamage, Padma Gunaratne, Pyara Ratnayake, Thashi Chang
BACKGROUND: The aetiological spectrum of acute encephalitis shows inter- and intra-geographical variations. We aimed to identify the viruses that cause infectious encephalitis in Sri Lanka, which represents a South Asian population. METHODS: A cross-sectional study was conducted among 99 patients with encephalitis/meningoencephalitis admitted to two tertiary-care hospitals in Colombo. Cerebrospinal fluid and serum were tested for conventional and emerging encephalitogenic viruses...
April 24, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28434069/herpes-zoster-keratitis-development-after-acute-retinal-necrosis
#7
Waseem H Ansari, Francesco Pichi, Paula E Pecen, Careen Y Lowder, Sunil K Srivistava
PURPOSE: To report a case of herpes zoster keratitis in a patient undergoing treatment for herpetic acute retinal necrosis. METHODS: Case report. RESULTS: A 71 year old male presented with acute retinal necrosis of the left eye due to herpes zoster and was treated with intravitreal foscarnet and oral valcyclovir. He developed a retinal detachment and underwent surgical repair. After four weeks, he developed an ipsilateral herpetic zoster keratitis demonstrated by Rose-Bengal staining that was responsive to topical ganciclovir gel...
April 22, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28429891/comparison-of-immunization-rates-of-adults-ages-65-years-and-older-managed-within-two-nurse-practitioner-owned-clinics-with-national-immunization-rates
#8
Wendy L Wright, Elise Morrell, Jennie Lee, Norma Graciela Cuellar, Patricia White
BACKGROUND AND PURPOSE: Adults ages ≥65 years are at increased risk for infectious diseases. Ensuring these individuals are fully vaccinated is imperative. The purpose of this study was to assess the immunization rates of adults ages ≥65 years managed by nurse practitioners (NPs) and compare the results with national immunization rates and Healthy People 2020 goals. METHODS: A convenience sample of adults ages ≥65 years was obtained from two NP-managed clinics...
April 21, 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28426274/a-critical-appraisal-of-shingrix-a-novel-herpes-zoster-subunit-hz-su-or-gsk1437173a-vaccine-for-varicella-zoster-virus
#9
Tehmina Bharucha, Damien Ming, Judith Breuer
HZ/Su, branded as 'Shingrix', is one of the newest vaccines to be submitted for multi-national regulatory approval. It is targeted to prevent shingles, predominantly affecting the elderly, but a global concern with ageing populations and significant associated morbidity and mortality. A vaccine for shingles has been available for over a decade, however it is contraindicated in specific subgroups of people, and there are added concerns regarding long-term immunogenicity. HZ/Su is the first subunit vaccine developed to protect against shingles...
April 20, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28416562/henry-head-herpes-zoster-and-the-graphic-development-of-his-scheme-of-the-dermatomes-in-man
#10
G D Schott
No abstract text is available yet for this article.
April 17, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28412701/association-between-medications-and-herpes-zoster-in-japanese-patients-with-rheumatoid-arthritis-a-5-year-prospective-cohort-study
#11
Sayoko Harada, Ryoko Sakai, Fumio Hirano, Nobuyuki Miyasaka, Masayoshi Harigai
OBJECTIVE: To investigate the association between medications and herpes zoster (HZ) in patients with rheumatoid arthritis (RA) given biological disease-modifying antirheumatic drugs (bDMARD) or conventional synthetic DMARD in the clinical setting during 5 years using the Registry of Japanese Rheumatoid Arthritis Patients on Biologics for Longterm Safety (REAL) database. METHODS: We calculated the crude incidence rate (IR) of HZ treated with systemic antiviral medications in 1987 patients from the REAL database...
April 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28412075/vaccine-preferences-and-acceptance-of-older-adults
#12
R Eilers, H E de Melker, J Veldwijk, P F M Krabbe
BACKGROUND: Expanding vaccination programs for the older population might be important as older adults are becoming a larger proportion of the general population. The aim of this study is to determine the relative importance of vaccine and disease specific characteristics and acceptance for Dutch older adults, including pneumococcal disease, herpes zoster, pertussis vaccination, and influenza vaccination. METHODS: A discrete choice experiment was conducted to generate choice data that was analyzed using a mixed multinomial logit statistical model...
April 12, 2017: Vaccine
https://www.readbyqxmd.com/read/28410358/reactivation-of-herpes-zoster-keratitis-with-corneal-perforation-after-zoster-vaccination
#13
Andre Jastrzebski, Seymour Brownstein, Setareh Ziai, Solin Saleh, Kay Lam, W Bruce Jackson
PURPOSE: We present a case of reactivated herpes zoster keratouveitis of 6 years duration with corneal perforation requiring penetrating keratoplasty shortly after inoculation with herpes zoster vaccine (Zostavax, Merck, Quebec, Canada). METHODS: Retrospective case report. RESULTS: A 67-year-old woman with a 5-year history of recurrent unilateral herpes zoster keratouveitis in her right eye presented with another recurrence 2 weeks after Zostavax vaccination...
April 12, 2017: Cornea
https://www.readbyqxmd.com/read/28408168/assessment-of-targeted-automated-messages-on-herpes-zoster-immunization-numbers-in-an-independent-community-pharmacy
#14
Brian W Bedwick, Gretchen K Garofoli, Betsy M Elswick
OBJECTIVES: To evaluate the impact of an automated phone call by a pharmacy owner on the number of herpes zoster vaccinations given in the independent community pharmacy setting, compare herpes zoster immunization numbers in the 3 months during the previous year to the 3 months during the intervention, and assess patient satisfaction with the automated phone call service. METHODS: This prospective study took place in an independent community pharmacy. A message was recorded by the pharmacy owner using a telephone-message program that notified patients aged 60 and older that the herpes zoster vaccine is recommended for them...
April 10, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28404679/evaluation-of-taqman-array-card-tac-for-the-detection-of-central-nervous-system-infections-in-kenya
#15
Clayton O Onyango, Vladimir Loparev, Shirley Lidechi, Vinod Bhullar, D Scott Schmid, Kay Radford, Michael K Lo, Paul Rota, Barbara W Johnson, Jorge Munoz, Martina Oneko, Deron Burton, Carolyn M Black, John Neatherlin, Joel M Montgomery, Barry Fields
Infections of the central nervous system (CNS) are often acute with significant morbidity and mortality. Routine diagnosis of such infections is limited in developing countries and requires modern equipment in advanced laboratories that may be unavailable to a number of patients in sub-Saharan Africa. We developed a TaqMan Array Card (TAC) that detects multiple pathogens simultaneously from cerebrospinal fluid (CSF). The 21-pathogen TAC assays include two parasites (Balamuthia mandrillaris and Acanthamoeba), six bacterial pathogens (Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Mycoplasma pneumoniae, Mycobacterium tuberculosis, and Bartonella) and 13 viruses (parechovirus, dengue, nipah, varicella zoster, mumps, measles, lyssa, herpes simplex virus 1 and 2, Epstein Barr virus, enterovirus, cytomegalovirus and chikungunya)...
April 12, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28401625/fatal-case-of-cutaneous-sparing-oro-laryngeal-zoster-in-a-renal-transplant-recipient
#16
Elie Helou, Matthew Grant, Marie Landry, Xinyu Wu, Jon S Morrow, Maricar F Malinis
Herpesvirus infections in solid organ transplant (SOT) recipients are a significant cause of morbidity and mortality. We report a case of herpes zoster (HZ) in a kidney transplant recipient while receiving belatacept, a CTLA-4 inhibitor that prevents acute rejection. The patient presented with oropharyngolaryngeal mucosal lesions that subsequently disseminated resulting in pneumonitis and meningo-encephalitis. Very late-onset HZ can occur and can present atypically in SOT recipients. Delayed recognition and treatment may result in poor outcomes, as illustrated by this case...
April 12, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28400201/inhibitors-of-dual-specificity-tyrosine-phosphorylation-regulated-kinases-dyrk-exert-a-strong-anti-herpesviral-activity
#17
Corina Hutterer, Jens Milbradt, Stuart Hamilton, Mirko Zaja, Johann Leban, Christophe Henry, Daniel Vitt, Mirjam Steingruber, Eric Sonntag, Isabel Zeitträger, Hanife Bahsi, Thomas Stamminger, William Rawlinson, Stefan Strobl, Manfred Marschall
Infection with human cytomegalovirus (HCMV) is a serious medical problem, particularly in immunocompromised individuals and neonates. The success of (val)ganciclovir therapy is hampered by low drug compatibility and induction of viral resistance. A novel strategy of antiviral treatment is based on the exploitation of cell-directed signaling, e. g. pathways with a known relevance for carcinogenesis and tumor drug development. Here we describe a principle for putative antiviral drugs based on targeting dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs)...
April 9, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28398421/herpes-zoster-following-varicella-vaccination-in-children
#18
Darren J Guffey, Sarah B Koch, Leonora Bomar, William W Huang
Herpes zoster (HZ), or shingles, is commonly seen in older adults but does occur in children. Routine administration of the varicella vaccine started in 1995 in the United States; since then, the incidence of varicella and HZ has declined. We report a case of HZ in an otherwise healthy 19-month-old boy who had been vaccinated at 13 months of age and recovered fully after acyclovir treatment. We review previously reported cases of HZ in healthy vaccinated children.
March 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28397528/skin-diseases-of-the-vulva-infectious-diseases
#19
Freja Lærke Sand, Simon Francis Thomsen
A multitude of infectious diseases of viral (genital herpes, herpes zoster, genital warts and molluscum contagiosum), bacterial (syphilis, chancroid, lymphogranuloma venereum, donovanosis, erysipelas, cellulitis and necrotising fasciitis, folliculitis, impetigo, bartholin gland abscess, trichomycosis and erythrasma), fungal (candidiasis and dermatophytosis) and parasitic (pediculosis pubis) origin may affect the vulvar area. Herein, we review the infections and their skin manifestations in the vulvar area.
April 11, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28397477/real-time-pcr-detection-of-the-most-common-bacteria-and-viruses-causing-meningitis
#20
Oya Akkaya, Hulya Iren Guvenc, Serife Yuksekkaya, Aysegul Opus, Asuman Guzelant, Meral Kaya, Muhammet Guzel Kurtoglu, Nurettin Kaya
BACKGROUND: Central nervous system (CNS) infections require prompt diagnosis, as the clinical condition progresses rapidly and may lead to severe permanent sequelae or death. The causative agents include viruses, bacteria, fungi, and parasites. In this study, samples with the diagnosis of CNS infection based on cerebrospinal fluid (CSF) sent to us from other hospitals/labs, were studied by multiplex real-time Polymerase Chain Reaction (PCR) method. The purpose of this study is to demonstrate, retrospectively, the most common bacteria and viruses causing meningitis and seasonal distribution of these agents using the multiplex real-time PCR method in CSF samples...
April 1, 2017: Clinical Laboratory
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