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https://www.readbyqxmd.com/read/29927827/custom-made-ocular-prosthesis-for-atrophic-anophthalmic-cavity
#1
Luísa Fernandes Monken, Luiza Vale Coelho, Matheus Silva Costa, José Alcides Almeida de Arruda, Ricardo Alves Mesquita, Amália Moreno
The ocular prosthesis is a modality of facial prosthesis that acts on the repair of loss or deformity of the ocular globe. Prosthetic rehabilitations destined to anophthalmic cavities that suffered cicatricial retraction represent a challenge during fabrication since they often need to be reduced due to atrophic of the cavity and simultaneously need to have a good esthetic appearance regarding the contour and artificial iris. This clinical report describes the ocular prosthetic rehabilitation of a 77-year-old man with anophthalmic atrophic cavity due to herpes zoster-induced loss...
June 20, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29924793/structure-of-the-herpes-simplex-virus-portal-vertex
#2
Marion McElwee, Swetha Vijayakrishnan, Frazer Rixon, David Bhella
Herpesviruses include many important human pathogens such as herpes simplex virus, cytomegalovirus, varicella-zoster virus, and the oncogenic Epstein-Barr virus and Kaposi sarcoma-associated herpesvirus. Herpes virions contain a large icosahedral capsid that has a portal at a unique 5-fold vertex, similar to that seen in the tailed bacteriophages. The portal is a molecular motor through which the viral genome enters the capsid during virion morphogenesis. The genome also exits the capsid through the portal-vertex when it is injected through the nuclear pore into the nucleus of a new host cell to initiate infection...
June 20, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29921616/study-of-complications-of-varicella-zoster-virus-infection-in-hospitalized-children-at-a-reference-hospital-for-infectious-disease-treatment
#3
Lilian Martins Oliveira Diniz, Marcelle Marie Martins Maia, Yara Vieira de Oliveira, Marina Santos Falci Mourão, Amanda Vieira Couto, Vânia Carneiro Mota, Carolina Mazieiro Versiani, Priscila Olívia da Costa Silveira, Roberta Maia Castro Romanelli
OBJECTIVES: Varicella is a disease with potentially severe complications. We aimed to investigate characteristics of hospitalized children with varicella in Brazil in the prevaccine period and to identify predictors for requiring intensive care treatment. METHODS: A prospective cohort study was conducted from May 2011 to April 2014. Patients up to 13 years of age with varicella diagnosis were included. Information was collected through interview and review of medical records...
June 19, 2018: Hospital Pediatrics
https://www.readbyqxmd.com/read/29920898/using-natural-language-processing-for-identification-of-herpes-zoster-ophthalmicus-cases-to-support-population-based-study
#4
Chengyi Zheng, Yi Luo, Cheryl Mercado, Lina Sy, Steven J Jacobsen, Brad Ackerson, Bruno Lewin, Hung Fu Tseng
IMPORTANCE: Diagnosis codes are inadequate for accurately identifying herpes zoster ophthalmicus (HZO). There is significant lack of population-based studies on HZO due to the high expense of manual review of medical records. BACKGROUND: To assess whether HZO can be identified from the clinical notes using natural language processing (NLP). To investigate the epidemiology of HZO among HZ population based on the developed approach. DESIGN: A retrospective cohort analysis...
June 19, 2018: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29913873/postherpetic-neuralgia-new-hopes-in-prevention-with-adult-vaccination-and-in-treatment-with-a-concentrated-capsaicin-patch
#5
Ewa Gawecka, Oddbjørn Viken
Background and purpose Postherpetic neuralgia (PHN) is a complication of acute herpes zoster (HZ). The evidence base for management of PHN has increased by recent publications. Therefore, we reviewed incidence of HZ, prevalence, risk factors, and mechanism of PHN pain, prevention and treatment of PHN with special interest in studies on adult vaccination and topical application of lidocaine and concentrated capsaicin patch. Methods We searched databases with an English language restriction: MEDLINE 1944-2011, EMBASE 1988-2011, PubMed, and the Cochrane Controlled Trial Register and Cochrane Library (2011)...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29910568/dermatological-manifestations-of-hiv-aids-individuals-in-shiraz-south-of-iran
#6
Mohammad Ali Davarpanah, Nasrin Motazedian, Farideh Jowkar
Introduction: HIV infection remains as a major challenge facing medical sciences in the world today. Mucocutaneous manifestation was first observed in patients with HIV/AIDS in the early 1980s. The aim of this study was to identify various skin manifestations based on making careful clinical observations and performing the necessary tests. Materials and Methods: A total of 240 patients whose disease was diagnosed using WB and ELISA tests, with dermatologic manifestations and were older than 18 years, participated in this study...
April 2018: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/29909132/receipt-of-other-routinely-recommended-vaccines-relative-to-receipt-of-seasonal-influenza-vaccines-trends-from-medicare-administrative-data-2013-2015
#7
Angela K Shen, Rob Warnock, Steve Chu, Jeffrey A Kelman
Annual influenza vaccination campaigns emphasize the importance of getting vaccinated against influenza. These campaigns offer potential opportunities to raise awareness of all vaccines. We explored the peak timing of the receipt of influenza and other routinely recommended vaccinations. We examined administrative claims data of 31 million Medicare fee-for-service beneficiaries, eligible to receive vaccinations administered from 2013 to 2015 from Medicare Part B (medical insurance) and Medicare Part D (prescription drug benefit)...
June 13, 2018: Vaccine
https://www.readbyqxmd.com/read/29908670/safety-and-efficacy-of-upadacitinib-in-patients-with-active-rheumatoid-arthritis-refractory-to-biologic-disease-modifying-anti-rheumatic-drugs-select-beyond-a-double-blind-randomised-controlled-phase-3-trial
#8
Mark C Genovese, Roy Fleischmann, Bernard Combe, Stephen Hall, Andrea Rubbert-Roth, Ying Zhang, Yijie Zhou, Mohamed-Eslam F Mohamed, Sebastian Meerwein, Aileen L Pangan
BACKGROUND: Phase 2 studies with upadacitinib, a selective Janus kinase 1 (JAK1) inhibitor, have shown safety and efficacy in the treatment of patients with active rheumatoid arthritis. We did this study to further assess the safety and efficacy of upadacitinib in patients with an inadequate response to biologic disease-modifying anti-rheumatic drugs (bDMARDs). METHODS: We did this double-blind, randomised controlled phase 3 trial at 153 sites in 26 countries. Patients were aged 18 years or older, had active rheumatoid arthritis and previous inadequate response or intolerance to bDMARDs, and were receiving concomitant background conventional synthetic DMARDS (csDMARDs)...
June 12, 2018: Lancet
https://www.readbyqxmd.com/read/29908669/safety-and-efficacy-of-upadacitinib-in-patients-with-rheumatoid-arthritis-and-inadequate-response-to-conventional-synthetic-disease-modifying-anti-rheumatic-drugs-select-next-a-randomised-double-blind-placebo-controlled-phase-3-trial
#9
Gerd R Burmester, Joel M Kremer, Filip Van den Bosch, Alan Kivitz, Louis Bessette, Yihan Li, Yijie Zhou, Ahmed A Othman, Aileen L Pangan, Heidi S Camp
BACKGROUND: Upadacitinib is a selective inhibitor of Janus kinase 1 and was efficacious in phase 2 studies in patients with moderate-to-severe rheumatoid arthritis. We aimed to assess the efficacy of upadacitinib in patients with inadequate response to conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs). METHODS: This study is a double-blind, placebo-controlled trial at 150 sites in 35 countries. We enrolled patients aged 18 years or older with active rheumatoid arthritis for 3 months or longer, who had received csDMARDs for at least 3 months with a stable dose for at least 4 weeks before study entry, and had an inadequate response to at least one of the following csDMARDs: methotrexate, sulfasalazine, or leflunomide...
June 12, 2018: Lancet
https://www.readbyqxmd.com/read/29907452/-herpes-zoster-ophthalmicus
#10
Alba Palmerín-Donoso, Manuel Tejero-Mas, Francisco Buitrago-Ramírez
No abstract text is available yet for this article.
June 12, 2018: Atencion Primaria
https://www.readbyqxmd.com/read/29905591/improving-herpes-zoster-vaccine-rates-the-impact-of-a-targeted-educational-program
#11
Margaret OʼDonnell, Kathleen Shurpin, Brenda Janotha
BACKGROUND AND PURPOSE: Despite demonstrated efficacy, the utilization of herpes zoster vaccine (HZV), recommended by the Centers for Disease Control (CDC) for all immunocompetent adults aged above 60 years, is low (31%). The aim of this study was to identify nurse practitioner (NP) barriers to HZV administration and then to use these results to develop and evaluate the outcomes of an educational program. METHODS: This study used a two-phase design. In Phase I, barriers that obstruct the provision of HZV were identified and NPs were surveyed to determine current HZV practice...
June 4, 2018: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29902492/analytical-validation-of-viral-cns-flow-chip-kit-for-detection-of-acute-meningitis-and-encephalitis
#12
Mercedes Pérez-Ruiz, Irene Pedrosa-Corral, Sara Sanbonmatsu-Gámez, Cristina Gómez-Camarasa, José María Navarro-Marí
A new molecular assay (Viral CNS Flow Chip kit, Master Diagnóstica, Spain) has been developed for the detection of eight viruses causing acute meningitis and encephalitis, i.e. herpes simplex viruses 1-2, varicella zoster virus, human enterovirus, human parechovirus, Toscana virus, human cytomegalovirus and Epstein Barr virus. The new assay is a multiplex one-step RT-PCR followed by automatic flow-through hybridization, colorimetric detection and image analysis. The limit of detection was 50 copies/reaction, and 10 copies/reaction for human enterovirus and the other seven viruses, respectively...
June 11, 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/29902266/statins-increase-the-risk-of-herpes-zoster-a-propensity-score-matched-analysis
#13
Min-Chul Kim, Sung-Cheol Yun, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Sung-Han Kim
OBJECTIVES: Statins, which are lipid-lowering agents, have anti-inflammatory and immunomodulatory properties that may affect the occurrence of various infectious diseases. We assessed whether statins increase the risk of herpes zoster (HZ) with propensity score-matching. METHODS: The study was based on the National Health Insurance database and its subset database of the "medical check-up" population of South Korea. These cohorts consist of about one million and 570,000 people, respectively, representative of the entire population of South Korea...
2018: PloS One
https://www.readbyqxmd.com/read/29900816/varicella-zoster-virus-and-urologic-practice-a-case-based-review
#14
Khushabu Kasabwala, Gilbert J Wise
INTRODUCTION: Each year, varicella-zoster virus (VZV) affects nearly one million people in the United States, often in the form of herpes zoster, or shingles. The urologic system is a rare but often debilitating target. This paper reviews the epidemiology, symptomatology, diagnosis, and management of VZV as it relates to urologic practice. MATERIALS AND METHODS: We performed a PubMed search using the query "herpes zoster" and "varicella-zoster virus" combined with multiple urological terms...
June 2018: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29896665/antiviral-drugs-against-alphaherpesvirus
#15
Kimiyasu Shiraki
The discovery of acyclovir and penciclovir has led to the development of a successful systemic therapy for treating herpes simplex virus infection and varicella-zoster virus infection, and the orally available prodrugs, valacyclovir and famciclovir, have improved antiviral treatment compliance. Acyclovir and penciclovir are phosphorylated by viral thymidine kinase and are incorporated into the DNA chain by viral DNA polymerase, resulting in chain termination. Helicase-primase plays an initial step in DNA synthesis to separate the double strand into two single strands (replication fork) and is a new target of antiviral therapy...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29896664/neurological-disorders-associated-with-human-alphaherpesviruses
#16
Jun-Ichi Kawada
Herpes simplex virus (HSV) encephalitis is the most common cause of sporadic fatal encephalitis worldwide, and central nervous system (CNS) involvement is observed in approximately one-third of neonatal HSV infections . In recent years, single-gene inborn errors of innate immunity have been shown to be associated with susceptibility to HSV encephalitis . Temporal lobe abnormalities revealed by magnetic resonance imaging-the most sensitive imaging method for HSV encephalitis-are considered strong evidence for the disease...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29895579/herpes-zoster-with-cutaneous-dissemination-a-rare-presentation-of-an-uncommon-pathology-in-children
#17
Catarina Faria, Ana Antunes, Henedina Antunes, Susana Carvalho
Herpes zoster, caused by varicella zoster virus (VZV) reactivation, affects mainly the adult population, although it can occur in children. This happens when primary infection (varicella) has occurred at a very young age or in immunocompromised patients. Complications are rare in healthy individuals. They include VZV cutaneous dissemination, which affects 2%-10% of immunocompromised patients.We present a previously healthy child, with history of varicella during her first month of life, which presented at age 8 with a severe case of herpes zoster, complicated with cutaneous dissemination...
June 12, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29894527/discoid-lupus-erythematosus-following-herpes-zoster
#18
Cynthia O Anyanwu, Lacy L Sommer, Halyna Kuzyshyn, Jeanette M Camacho, Hala M Eid, Warren R Heymann
The isomorphic response is the appearance of new lesions from a preexisting skin condition at a site of trauma. Discoid lupus erythematosus (DLE) may develop on traumatized skin and also may arise at sites of a prior cutaneous eruption. We report the case of a 20-year-old woman with a history of systemic lupus erythematosus (SLE) and DLE who developed a painful, multidermatomal, vesicular rash on the left breast and back consistent with herpes zoster (HZ) during treatment with systemic immunosuppression. Four months after the HZ resolved, the patient developed new-onset DLE lesions within the prior HZ-affected dermatomes...
May 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29889693/lupus-and-vaccinations
#19
Alexis Mathian, Micheline Pha, Zahir Amoura
PURPOSE OF REVIEW: To review the latest data in the field of vaccinations in systemic lupus erythematosus (SLE), focusing on pneumococcal, seasonal influenza, herpes zoster and human papillomavirus infections. RECENT FINDINGS: Less than 40% of patients responded adequately to the 23-valent pneumococcal polysaccharide (PPS23) vaccine. A randomized controlled trial showed that sequential administration of the pneumococcal conjugate vaccine followed by the PPS23 vaccine was well tolerated but was not superior to the PPS23 vaccine alone in terms of immunogenicity...
June 9, 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29889070/herpes-viruses-and-senile-dementia-first-population-evidence-for-a-causal-link
#20
Ruth F Itzhaki, Richard Lathe
Three articles have very recently appeared that are of especial relevance to the causes of dementia and its potential treatment. The first two (Tsai et al., published in PLoS One in November 2017; Chen et al., published in the January/February 2018 issue of Journal of Clinical Psychiatry) demonstrate an increased risk of subsequent senile dementia (SD) development in patients with acute varicella zoster (herpes zoster) infection. These articles present data highly relevant to the third, and most important, paper-by Tzeng et al...
June 4, 2018: Journal of Alzheimer's Disease: JAD
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