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Herpes zoster

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https://www.readbyqxmd.com/read/27925894/prevention-of-herpes-zoster-and-its-complications-from-clinical-evidence-to-real-life-experience
#1
Giovanni Gabutti, Paolo Bonanni, Michele Conversano, Guido Fanelli, Elisabetta Franco, Donato Greco, Giancarlo Icardi, Marzia Lazzari, Alessandro Rossi, Silvestro Scotti, Antonio Volpi
Herpes zoster (HZ) is an acute viral illness characterized by a vesicular rash with unilateral distribution, which can also result in severe complications such as post-herpetic neuralgia (PHN), ophthalmic zoster, stroke or other neurological complications. The estimate incidence in Europe ranges between 2.0 and 4.6 cases per 1,000 person-years, with a sharp increase in >50 year-old subjects. Currently, treatment options for HZ are only partially effective in limiting the acute phase, while the management of complications is complex and often unsatisfactory...
December 7, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27925856/clinical-and-economic-impact-of-herpes-zoster-vaccination-in-elderly-in-italy
#2
Sara Boccalini, Cristiano Alicino, Domenico Martinelli, Angela Bechini, Emilia Tiscione, Barbara Pellizzari, Rosa Prato, Giancarlo Icardi, Stefania Iannazzo, Paolo Bonanni
Herpes zoster (HZ) is a very relevant pathology among elderly people (≥ 60 years of age), with a considerable disease burden and loss of quality of life. In the last years a new vaccine against HZ became available in Italy. Therefore, the Italian decision makers are now confronted with the decision whether that vaccination should be implemented. Pharmaco-economic analyses represent useful tools to value the feasibility of new immunization programs and their sustainability. To this aim, an ad hoc population model was developed in order to value the clinical and economic impact of HZ vaccination program for the elderly in Italy...
December 7, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27925843/incidence-of-herpes-zoster-and-post-herpetic-neuralgia-in-italy-results-from-a-three-years-population-based-study
#3
Cristiano Alicino, Cecilia Trucchi, Chiara Paganino, Ilaria Barberis, Sara Boccalini, Domenico Martinelli, Barbara Pellizzari, Angela Bechini, Andrea Orsi, Paolo Bonanni, Rosa Prato, Stefania Iannazzo, Giancarlo Icardi
Herpes Zoster (HZ) and its main complication, post-herpetic neuralgia (PHN), represent important public health issues because of their relevant burden among older adults. However, data on the epidemiology of HZ and PHN in Italy are very limited. A population-based study was performed by seeking for cases of HZ and PHN, occurred in the period 2013-2015, in the clinical charts of 56 General Practitioners working in four Italian Regions (Liguria, Puglia, Toscana and Veneto). The main objective of the study was to estimate the incidence of HZ and the proportion of PHN (at 1 and 3 months from the onset of HZ; PHN1 and PHN3) among people aged ≥ 50 years...
December 7, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27924350/-use-of-intracutaneous-or-subcutaneous-botulinum-toxin-for-postherpetic-neuralgia
#4
L Halb, B J Amann, H Bornemann-Cimenti
BACKGROUND: Botulinum neurotoxin (BoNT), a toxin of the anaerobic spore-forming bacterium Clostridium botulinum is used as a drug for alleviating muscle spasticity. Other indications include the cosmetic application in facial muscles, hyperhidrosis and neurogenic bladder disorders. It has been approved since 2010 as the first prophylactic treatment for chronic migraine. The analgesic effect of BoNT was observed early on and is currently the subject of intensive research. Painful postherpetic neuralgia is a common complication of an infection with herpes zoster virus...
December 6, 2016: Der Nervenarzt
https://www.readbyqxmd.com/read/27918431/evaluation-of-microrna-expression-in-patients-with-herpes-zoster
#5
Xihan Li, Ying Huang, Yucheng Zhang, Na He
Reactivated varicella-zoster virus (VZV), which lies latent in the dorsal root ganglions and cranial nerves before its reactivation, is capable of causing herpes zoster (HZ), but the specific mechanism of virus reactivation and latency remains unknown. It was proposed that circulating microRNAs (miRNAs) in body fluids could potentially indicate infection. However, the connection between herpes zoster and circulating miRNAs has not been demonstrated. In this study, 41 HZ patients without superinfection were selected...
December 2, 2016: Viruses
https://www.readbyqxmd.com/read/27917531/burden-of-herpes-zoster-and-postherpetic-neuralgia-in-japanese-adults-60-years-of-age-or-older-results-from-an-observational-prospective-physician-practice-based-cohort-study
#6
Keiko Sato, Koichi Adachi, Hiroyuki Nakamura, Kazuhiro Asano, Akihiro Watanabe, Riri Adachi, Mariko Kiuchi, Keiju Kobayashi, Taizo Matsuki, Toshihiko Kaise, Kusuma Gopala, Katsiaryna Holl
Approximately one in three persons will develop herpes zoster during their lifetime, and it can lead to serious complications such as postherpetic neuralgia. However, evidence on burden of herpes zoster and postherpetic neuralgia in Japan is limited. This prospective, observational, multicenter, physician practice-based cohort study was conducted in Kushiro, Hokkaido, Japan (Clinicaltrials.gov identifier NCT01873365) to assess the incidence and hospitalization rates of herpes zoster, and the proportion, clinical burden and risk factors for postherpetic neuralgia in adults aged 60 years or more...
December 5, 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/27917091/vaccinating-patients-with-inflammatory-bowel-disease
#7
Jason Reich, Sharmeel Wasan, Francis A Farraye
Patients with inflammatory bowel disease (IBD) are not vaccinated at the same rate as general medical patients. IBD places patients at increased risk for developing vaccine-preventable illnesses, and this risk is further exacerbated by immunosuppressive therapy. Therefore, gastroenterologists should familiarize themselves with health maintenance measures pertaining to patients with IBD. This article highlights the vaccinations required for patients with IBD, especially those who are immunosuppressed: influenza; pneumococcal pneumonia; hepatitis A and B viruses; human papilloma virus; meningococcal disease; tetanus, diphtheria, and pertussis; measles, mumps, and rubella; varicella zoster; and herpes zoster...
September 2016: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27916198/-zodiac-consensus-on-herpes-zoster-prevention-in-persons-with-diabetes-mellitus
#8
Esther Redondo Margüello, Dídac Mauricio, José Javier Mediavilla Bravo, Alfonso Soto González, Elías Delgado Álvarez, F Javier Ampudia-Blasco, Esteban Jódar Gimeno
No abstract text is available yet for this article.
November 2016: Semergen
https://www.readbyqxmd.com/read/27911430/-clinical-presentations-of-herpes-zoster-ophthalmicus-diagnosis-and-therapy
#9
G M Chernakova, E A Kleshcheva, T B Semenova
: Approximately a quarter of the world's population at some point in life is at risk of developing shingles (Herpes Zoster). In 10-20% of cases the first branch of the trigeminal nerve gets involved (Herpes Zoster Ophthalmicus, HZO). Ophthalmic complications of HZO are able to cause a significant reduction in visual function. AIM: To study and summarize clinical features of HZO (including the rate of complications and their nature) and to determine the relationship between clinical and laboratory data from these patients...
2016: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/27911112/treatment-of-alpha-and-beta-herpesvirus-infections-in-solid-organ-transplant-recipients
#10
C L Abad, R R Razonable
Human herpesviruses frequently cause infections in solid organ transplant (SOT) recipients. Areas covered: We provide an overview of the clinical impact of alpha and beta herpesviruses and highlight the mechanisms of action, pharmacokinetics, clinical indications, and adverse effects of antiviral drugs for the management of herpes simplex virus, varicella zoster virus and cytomegalovirus. We comprehensively evaluated key clinical trials that led to drug approval, and served as the foundation for management guidelines...
December 2, 2016: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/27904277/herpes-zoster-duplex-unilateralis-two-cases-and-brief-literature-review
#11
Jee Hee Son, Bo Young Chung, Hye One Kim, Hee Jin Cho, Chun Wook Park
Cases involving dermatomal herpes zoster in two or more locations are rare, especially in immunocompetent patients. When two noncontiguous dermatomes are involved, if affected unilaterally, it is called herpes zoster duplex unilateralis; if bilaterally, bilateralis. Here, we report two cases of herpes zoster duplex unilateralis. A 66-year-old man presented with painful erythematous grouped vesicles on his left scalp, forehead, trunk, and back (left [Lt.] V1, Lt. T8). Histologic findings were consistent with herpetic infection...
December 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27904265/a-study-of-intravenous-administration-of-vitamin-c-in-the-treatment-of-acute-herpetic-pain-and-postherpetic-neuralgia
#12
Min Sung Kim, Dong Jin Kim, Chan Ho Na, Bong Seok Shin
BACKGROUND: Although there are several available management strategies for treatment of both acute pain of herpes zoster (HZ) and postherpetic neuralgia (PHN), it is difficult to treat them adequately. OBJECTIVE: The aim of this study was to evaluate the efficacy of intravenously administrated vitamin C on acute pain and its preventive effects on PHN in patients with HZ. METHODS: Between September 2011 and May 2013 eighty-seven patients who were admitted for HZ were assessed according to age, sex, underlying diseases, duration of pain and skin lesion, dermatomal distribution, and PHN...
December 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27904197/myelitis-a-rare-neurological-complication-of-herpes-zoster
#13
Monika Mohanbhai Agrawal, Rashmi Samir Mahajan, Freny Erachshaw Bilimoria, Kishan Rasubhai Ninama
No abstract text is available yet for this article.
November 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27902409/prevention-of-herpes-zoster-and-its-complications-from-the-clinic-to-the-real-life-experience-with-the-vaccine
#14
Giovanni Gabutti, Nicoletta Valente, Parvanè Kuhdari, Silvia Lupi, Armando Stefanati
The Herpes Zoster (HZ) is an acute viral illness characterized by a vesicular rash, with unilateral distribution, which can eventually cause severe complications, such as the post-herpetic neuralgia (PHN), the ophthalmic zoster, stroke or other neurological complications. In Europe, an incidence between 2.0 and 4.6 cases per 1,000 persons-year is estimated, with an increase after 50 years of age. Currently, the therapeutic options for HZ are only partially effective to limit the acute phase, while the management of complications is frequently complex and not satisfactory...
November 4, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27896624/autologous-bone-marrow-stem-cell-transplantation-for-the-treatment-of-ulcerative-colitis-complicated-with-herpes-zoster-a-case-report
#15
Hang Xiang, Xiaomei Zhang, Chao Yang, Wenhuan Xu, Xin Ge, Rong Zhang, Ya Qiu, Wanjun Sun, Fan Li, Tianyuan Xiang, Haixu Chen, Zheng Wang, Qiang Zeng
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with continuous or recurrent symptoms. A 42-year-old male patient with intermittent diarrhea accompanied by bloody mucopurulent stools was admitted to our hospital. The diagnosis of UC was confirmed by a combination of laboratory examination, colonoscopy, and histological assay. The patient developed herpes zoster in the hospital, which challenged traditional treatments. Therefore, we performed an autologous bone marrow cells to modulate the immune system with his permission...
November 28, 2016: Frontiers of Medicine
https://www.readbyqxmd.com/read/27895041/infections-and-the-risk-of-incident-giant-cell-arteritis-a-population-based-case-control-study
#16
Rennie L Rhee, Peter C Grayson, Peter A Merkel, Gunnar Tomasson
OBJECTIVES: Alterations in the immune system and infections are suspected to increase susceptibility to giant cell arteritis (GCA). Recently herpes zoster has been directly implicated in the pathogenesis of GCA. We examined the association between prior infections, in particular herpes zoster, and incident GCA in a population-based cohort. METHODS: A nested case-control study was performed using an electronic database from the UK. Cases with newly diagnosed GCA were identified using a validated algorithm and compared with age-matched, sex-matched and practice-matched controls...
November 28, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27890172/opportunistic-infections-in-biological-therapy-risk-and-prevention
#17
REVIEW
Paul A Bryant, John W Baddley
Patients being treated with biological therapies are at increased risk for serious infections, including opportunistic infections. Although more is known about opportunistic infection risk with older biologics, such as antitumor necrosis factor drugs, there is less knowledge of opportunistic infection risk with newer biological therapies. The incidence of certain opportunistic infections (tuberculosis, herpes zoster, pneumocystosis) has been rigorously evaluated in large observational studies. However, data are more limited for other infections (histoplasmosis, nontuberculous mycobacteria)...
February 2017: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/27890168/incidence-and-prevention-of-herpes-zoster-reactivation-in-patients-with-autoimmune-diseases
#18
REVIEW
Eliza F Chakravarty
Herpes zoster is the reactivation of latent varicella zoster virus usually occurring decades after initial exposure, and manifesting as a painful vesicular rash occurring along one or more dermatomes. Zoster incidence increases with age as cell mediated immunity against latent virus wanes. Epidemiological evidence suggests that individuals with underlying rheumatic diseases are at increased risk for zoster. It remains unclear whether this is due to immunosuppressive medications or from immune dysregulation of the underlying disease...
February 2017: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/27881354/-analysis-of-immune-suppression-in-patients-with-systemic-lupus-erythematosus-complicated-by-herpes-zoster-virus-infection
#19
Hui Ouyang, Xue-Chang He, Yi Zhou, Zhao-Xia Li
OBJECTIVE: To explore the changes in cellular immune function and the safety of physical therapy in patients with systemic lupus erythematosus (SLE) complicated by herpes zoster (HZ) virus infection. Methods A retrospective analysis was conducted among 10 SLE pateints with HZ virus infection, with 30 SLE patients without HZ infection as the control group. The results of routine laboratory tests and T lymphocyte subset counts (before and during infection and after cure of infection) were compared between the two groups...
November 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27880853/risk-of-stroke-after-herpes-zoster-evidence-from-a-german-self-controlled-case-series-study
#20
Tania Schink, Sigrid Behr, Kathrin Thöne, Hélène Bricout, Edeltraut Garbe
BACKGROUND: Herpes zoster (HZ) is caused by reactivation of the latent varicella-zoster virus (VZV). A severe complication of HZ is VZV vasculopathy which can result in ischemic or hemorrhagic stroke. The aims of our study were to assess the risk of stroke after the onset of HZ and to investigate the roles of stroke subtype, HZ location and the time interval between HZ onset and stroke. METHODS: A self-controlled case-series study was performed on a cohort of patients with incident stroke recorded in the German Pharmacoepidemiological Research Database (GePaRD), which covers about 20 million persons throughout Germany...
2016: PloS One
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