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https://www.readbyqxmd.com/read/29667858/longitudinal-analysis-of-varicella-zoster-virus-specific-antibodies-in-systemic-lupus-erythematosus-no-association-with-subclinical-viral-reactivations-or-lupus-disease-activity
#1
C Rondaan, C C van Leer, S van Assen, H Bootsma, K de Leeuw, S Arends, N A Bos, J Westra
Systemic lupus erythematosus (SLE) patients are at high risk of herpes zoster. Previously, we found increased immunoglobulin (Ig)G levels against varicella-zoster virus (VZV) in SLE patients compared to controls, while antibody levels against diphtheria and cellular immunity to VZV were decreased. We aimed to test our hypothesis that increased VZV-IgG levels in SLE result from subclinical VZV reactivations, caused by stress because of lupus disease activity or immunosuppressive drug use. Methods Antibody levels to VZV (IgG, IgA, IgM), total IgG and VZV-DNA were longitudinally determined in the serum of 34 SLE patients, using enzyme-linked immunosorbent assay and polymerase chain reaction...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29667330/no-increased-risk-of-herpes-zoster-in-tnf-inhibitor-and-non-tnf-inhibitor-users-with-rheumatoid-arthritis-epidemiological-study-using-the-japanese-health-insurance-database
#2
Ryoko Sakai, Shoko Kasai, Fumio Hirano, Sayoko Harada, Mari Kihara, Waka Yokoyama, Michi Tsutsumino, Kenji Nagasaka, Ryuji Koike, Hisashi Yamanaka, Nobuyuki Miyasaka, Masayoshi Harigai
OBJECTIVE: It is controversial whether the use of biological disease-modifying antirheumatic drugs (DMARDs) increases the risk of herpes zoster (HZ). We aimed to evaluate the risks of HZ in tumor necrosis factor inhibitor (TNFI) and non-TNFI users with rheumatoid arthritis (RA) over 3 years in Japan. METHOD: Using the Japanese health insurance database, we assigned patients with at least one RA diagnostic code and one prescription for any DMARDs (RA cases) recorded between January 2005 and December 2013 to the RA group...
April 17, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29661022/low-rates-of-vaccination-for-herpes-zoster-in-older-people-living-with-hiv
#3
Kristine M Erlandson, Amber Streifel, Alexander Novin, Kellie Hawkins, Clayton Foster, Jacob Langness, Mary Bessesen, Julian Falutz, Abeer Moanna, David Looney, Scott Johns, Joseph Nguyen, Michael Oxman, Myron Levin
BACKGROUND: Herpes zoster (HZ) occurs at a higher age-specific rate in people living with HIV (PLWH) than in the general population. We implemented a quality improvement study to assess herpes zoster vaccine (HZV) usage among PLWH, assess HZV usage after additional reminders/prompts, and identify barriers to HZV among older PLWH. METHODS: HZV rates in PLWH were determined in six institutions with varying payment structures. For the intervention, Part 1, PLWH eligible for HZV at the University of Colorado were identified, and providers were notified of patient eligibility...
April 17, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29659663/real-world-evidence-for-regulatory-decisions-concomitant-administration-of-zoster-vaccine-live-and-pneumococcal-polysaccharide-vaccine
#4
Katia Bruxvoort, Lina S Sy, Yi Luo, Hung Fu Tseng
The US Food and Drug Administration is charged with expanding the use of real world evidence (RWE) for regulatory decisions. As a test case for RWE to support regulatory decisions, we present the scenario of concomitant vaccination with zoster vaccine live (ZVL) and 23-valent pneumococcal polysaccharide vaccine (PPSV23). The prescribing information states that these vaccines should not be given concurrently, based on a small trial using varicella zoster virus antibody levels as a correlate of ZVL efficacy, even though ZVL protects against herpes zoster via cell-mediated immunity...
April 11, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29653205/varicella-zoster-virus-reactivation-in-adult-survivors-of-hematopoietic-cell-transplantation-how-do-we-best-protect-our-patients
#5
REVIEW
Catherine J Lee, Bipin N Savani, Per Ljungman
Reactivation of varicella zoster virus (VZV) remains a significant public health burden for long-term survivors of hematopoietic cell transplantation. Delayed immune reconstitution after transplantation due to immunosuppression, posttransplant therapies, poor engraftment, and graft-versus-host disease leave a large number of patients at risk for herpes zoster (shingles) and its highly morbid complications. Although prophylaxis with acyclovir or valacyclovir has reduced the incidence of VZV reactivation as long as prophylaxis is continued, the incidence of disease in the late posttransplant period or after stopping prophylaxis is greater in the HCT population than the general public...
April 10, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29650086/influenza-pneumococcal-hepatitis-b-and-herpes-zoster-vaccinations
#6
Nadira Husein, Ashen Chetty
No abstract text is available yet for this article.
April 2018: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29644194/safety-and-efficacy-of-different-systemic-treatment-modalities-for-acute-pain-of-herpes-zoster-a-pilot-study
#7
Sanjiv Choudhary, Shivani Dhande, Sachin Kharat, A L Singh
Background: Herpes zoster is a viral infection of skin caused by Varicella Zoster virus. The most important symptom for which the patient seeks medical advice is pain, which is perceived before the development of rash and lasts even after its resolution. The pain during the first 30 days after onset of herpes zoster is known as acute herpetic neuralgia. The aim of this study was to compare the efficacy and side-effects of different systemic treatment modalities for acute herpes zoster neuralgia...
March 2018: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29626377/classic-paper-are-the-chickenpox-virus-and-the-zoster-virus-identical-helmut-ruska
#8
Detlev H Kruger, Thomas Mertens
As early as 1943, the German physician Helmut Ruska visualized the virus of varicella and zoster (at that time, he was not completely certain whether the virus was the same) by the newly developed electron microscope; he is regarded as the discoverer of this virus. Here, we present a translation of his classical paper into the English language. In our introduction and commentary to his paper, we discuss the significance of Helmut Ruska's work for the development of virology, his distinction between the varicella, zoster, and herpes virus group on one hand and poxviruses on the other, as well as the development of imaging techniques which have refined or substituted for electron microscopy of viruses and virus-infected cells...
April 6, 2018: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29622669/secular-trends-in-infection-related-mortality-after-kidney-transplantation
#9
Susanna Kinnunen, Pauli Karhapää, Auni Juutilainen, Patrik Finne, Ilkka Helanterä
BACKGROUND AND OBJECTIVES: Infections are the most common noncardiovascular causes of death after kidney transplantation. We analyzed the current infection-related mortality among kidney transplant recipients in a nationwide cohort in Finland. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Altogether, 3249 adult recipients of a first kidney transplant from 1990 to 2012 were included. Infectious causes of death were analyzed, and the mortality rates for infections were compared between two eras (1990-1999 and 2000-2012)...
April 5, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29621875/the-risk-of-herpes-zoster-in-patients-with-non-small-cell-lung-cancer-according-to-chemotherapy-regimens-tyrosine-kinase-inhibitors-versus-cytotoxic-chemotherapy
#10
Ji Young Choi, Miso Kim, Bhumsuk Keam, Tae Min Kim, Dong-Wan Kim, Dae Seog Heo, Seong Jin Jo
Purpose: Despite the successful use of tyrosine kinase inhibitors (TKIs) in cancer patients, their effect on herpes zoster development has not been studied. The aim of this study was to evaluate and compare the effects of epidermal growth factor receptor (EGFR) TKI and cytotoxic chemotherapy on the risk of herpes zoster development in non-small cell lung cancer (NSCLC) patients. Materials and Methods: We conducted a medical review of all eligible NSCLC patients in Seoul National University hospital between 2002 and 2015...
April 5, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29621623/maritime-varicella-illness-and-death-reporting-u-s-2010-2015
#11
Marion E Rice, Millicent Bannerman, Mona Marin, Adriana Lopez, Melissa M Lewis, Caroline Stamatakis, Joanna Regan
BACKGROUND: Ships destined for, or departing from, U.S. ports of entry must report certain signs and symptoms of potentially communicable diseases of public health interest among travelers to the Division of Global Migration and Quarantine (DGMQ) at the Centers for Disease Control and Prevention. METHODS: We reviewed ships' varicella case and outbreak reports from January 2010 through December 2015. RESULTS: DGMQ received 967 reports of varicella and 13 reports of herpes zoster...
April 2, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29619848/biological-treatment-for-psoriasis-and-the-risk-of-herpes-zoster-results-from-the-psoriasis-longitudinal-assessment-and-registry-psolar
#12
Guy Shalom, Luigi Naldi, Mark Lebwohl, Arjen Nikkels, Elke M G J de Jong, Steven Fakharzadeh, Kavitha G Goyal, Bhaskar Srivastava, Wayne Langholff, Claudia Galindo, Arnon D Cohen
PURPOSE: To describe the risk of herpes zoster (HZ) in patients with psoriasis and its relation to non-biologic systemic therapies or biologic treatment. MATERIALS AND METHODS: Psoriasis Longitudinal Assessment and Registry (PSOLAR) is an international, prospective, registry that follows adult patients with psoriasis eligible to receive non-biologic systemic therapies or biologic therapies. Mutually exclusive therapy cohorts were defined. HZ incident rates were calculated for each therapy cohort and rates between cohorts were compared using hazard ratios (HR) adjusted for potential confounders, in new users and prevalent-exposure patients...
April 5, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29615269/the-public-health-value-of-vaccination-for-seniors-in-europe
#13
REVIEW
Susanna Esposito, Elisabetta Franco, Gaetan Gavazzi, Angel Gil de Miguel, Roland Hardt, George Kassianos, Isabelle Bertrand, Marie-Cécile Levant, Benoit Soubeyrand, Jose Antonio López Trigo
Longer life expectancy and decreasing fertility rates mean that the proportion of older people is continually increasing worldwide, and particularly in Europe. Ageing is associated with an increase in the risk and severity of infectious diseases. These diseases are also more difficult to diagnose and manage in seniors who often have at least one comorbid condition (60% of seniors have two or more conditions). Infectious diseases increase the risk of hospitalization, loss of autonomy and death in seniors. Effective vaccines are available in Europe for infectious diseases such as influenza, pneumococcal diseases, herpes zoster, diphtheria, tetanus and pertussis...
March 31, 2018: Vaccine
https://www.readbyqxmd.com/read/29607919/-rapidly-deteriorated-lobar-intracerebral-hemorrhages-possible-association-of-varicella-zoster-virus-vasculopathy
#14
Jun Takeshita, Eiichi Nomura, Makoto Takemaru, Takahiro Himeno, Yutaka Shimoe, Masaru Kuriyama
A 75-year-old man having dementia and lifestyle related diseases developed a lobar intracerebral hemorrhage (LICH) in the left parietal and a small cerebellar infarction in the left occipital lobe. Many micro bleeds (MB) due to cerebral amyloid angiopathy (CAA) in the subcortical areas and multiple vascular stenosis were also found by MRI and MRA. He developed herpes zoster in his buttocks on day 6 of hospitalization and complicated with varicella zoster virus (VZV) meningitis with positive for VZV-DNA in the cerebrospinal fluid...
March 31, 2018: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29607871/herpes-zoster-induced-acute-urinary-retention-two-cases-and-literature-review
#15
H He, C Tang, X Yi, W Zhou
We report two uncommon cases of acute urinary retention in Chinese patients caused by reactivation of sacral herpes zoster and requiring bladder drainage. Indwelling urinary catheterization, antiviral medication (ganciclovir), and physiotherapy with infrared light (830 nm) led to successful recovery of the micturition reflex in both cases.
April 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29606835/validation-of-herpes-zoster-diagnosis-code-in-the-electronic-medical-record-a-retrospective-multicenter-study
#16
Yoon Seob Kim, Hyun-Min Seo, Chul Hwan Bang, Ji Hyun Lee, Yong-Gyu Park, You Jeong Kim, Gyong Moon Kim, Chul Jong Park, Hyun Jeong Park, Dong Soo Yu, Jun Young Lee, Young Min Park
No abstract text is available yet for this article.
April 2018: Annals of Dermatology
https://www.readbyqxmd.com/read/29606812/usefulness-of-inflammatory-markers-for-the-prediction-of-postherpetic-neuralgia-in-patients-with-acute-herpes-zoster
#17
Jun Young Kim, Gyeong-Hun Park, Min Ji Kim, Hyun Bo Sim, Weon Ju Lee, Seok-Jong Lee, Shin-Woo Kim, Young Hoon Jeon, Yong Hyun Jang, Do Won Kim
Background: Increasing evidence suggests a pivotal role for neuronal inflammation in response to replicating varicella zoster virus in the development of postherpetic neuralgia (PHN). Objective: In this study, we investigated the value of serum levels of various inflammatory markers in acute herpes zoster (HZ) as predictors for the development of PHN. Methods: A total of 116 patients with acute HZ were enrolled in this study. We measured scores on the pain visual analogue scale (VAS) at baseline and at 1, 3, and 6 months after diagnosis of HZ...
April 2018: Annals of Dermatology
https://www.readbyqxmd.com/read/29602095/viral-load-and-antibody-boosting-following-herpes-zoster-diagnosis
#18
Charlotte Warren-Gash, Harriet Forbes, Peter Maple, Mark Quinlivan, Judith Breuer
BACKGROUND: Acute varicella zoster virus (VZV) replication in shingles is accompanied by VZV antibody boosting. It is unclear whether persisting virus shedding affects antibody levels. OBJECTIVES: To investigate the relationship between VZV viral load and antibody titres in shingles patients during six months following diagnosis and assess whether VZV antibody titre could discriminate patients with recent shingles from healthy population controls. STUDY DESIGN: A prospective study of 63 patients with active zoster...
March 21, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29601366/risk-of-anterior-segment-complications-associated-with-the-live-herpes-zoster-vaccine-evidence-from-a-health-claim-database
#19
Rhuozhou Tom Liu, Sonia N Yeung, Bruce Carleton, Mahyar Etminan
PURPOSE: To determine the risk of developing anterior segment complications after receiving the live herpes zoster virus vaccine. METHODS: This retrospective cohort study included a random sample of 9 million patients registered in a health-claim database in the United States between 2006 and 2016. Herpes zoster-related anterior segment diseases were identified by International Classification of Diseases ninth or tenth edition codes (an event). Patients without any event before index dates were separated into cohorts 1 and 2...
March 28, 2018: Cornea
https://www.readbyqxmd.com/read/29599765/herpesviruses-in-the-activated-phosphatidylinositol-3-kinase-%C3%AE-syndrome
#20
REVIEW
Jeffrey I Cohen
The phosphatidylinositol-3-kinase (PI3K)/Akt pathway is important for multiple stages of herpesvirus replication including virus entry, replication, latency, and reactivation. Recently, patients with gain-of-function mutations in the p110δ-catalytic subunit of PI3K or in the p85-regulatory subunit of PI3K have been reported. These patients have constitutively active PI3K with hyperactivation of Akt. They present with lymphoproliferation and often have infections, particularly recurrent respiratory infections and/or severe virus infections...
2018: Frontiers in Immunology
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