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Platelet rich fibrine

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https://www.readbyqxmd.com/read/29671861/p2y12-antagonist-ticagrelor-inhibits-the-release-of-procoagulant-extracellular-vesicles-from-activated-platelets-preliminary-results
#1
Aleksandra Gasecka, Rienk Nieuwland, Edwin van der Pol, Najat Hajji, Agata Ćwiek, Kinga Pluta, Michał Konwerski, Krzysztof J Filipiak
BACKGROUND: Activated platelets release platelet extracellular vesicles (PEVs). Adenosine diphosphate (ADP) receptors P2Y1 and P2Y12 both play a role in platelet activation, The present hypothesis herein is that the inhibition of these receptors may affect the release of PEVs. METHODS: Platelet-rich plasma from 10 healthy subjects was incubated with saline, P2Y1 antagonist MRS2179 (100 µM), P2Y12 antagonist ticagrelor (1 µM), and a combination of both antagonists...
April 19, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/29662262/treatment-of-endo-periodontal-lesion-using-leukocyte-platelet-rich-fibrin-a-case-report
#2
Pablo Betancourt, Ricardo Elgueta, Ramon Fuentes
Case Description: The main objective of this paper was to report the clinical effectiveness of leukocyte- platelet- rich fibrin (L-PRF) in the treatment of a combined endo-periodontal lesion of an upper first premolar. Clinical Findings: The tooth had a profound abfraction on the vestibular aspect and presented no mobility but revealed a deep pocket measuring of 11 mm on the mesial vestibular aspect and 14 mm on the mesial palatine aspect. The three dimensional image analysis showed total bone loss in the mesial aspect and an extensively bone loss of the vestibular aspect of the vestibular root...
December 30, 2017: Colombia Médica: CM
https://www.readbyqxmd.com/read/29629438/influence-of-leukocyte-and-platelet-rich-fibrin-l-prf-on-the-outcomes-of-impacted-mandibular-third-molar-removal-surgery-a-split-mouth-randomized-clinical-trial
#3
Povilas Daugela, Vaidas Grimuta, Dalius Sakavicius, Juozas Jonaitis, Gintaras Juodzbalys
OBJECTIVES: The purpose of this study was to evaluate the influence of leukocyte- and platelet-rich fibrin (L-PRF) on impacted mandibular third molar (IMTM) extraction wound healing, patient postoperative discomfort, and incidence of alveolar osteitis. METHOD AND MATERIALS: Thirty-four patients (20 female, 14 male) who met the inclusion criteria for this split-mouth randomized clinical trial were enrolled and 30 patients completed the study. Patients were randomized and underwent bilateral IMTM surgical extractions...
2018: Quintessence International
https://www.readbyqxmd.com/read/29607842/a-clinicoradiographic-comparison-of-the-effects-of-platelet-rich-fibrin-gel-and-platelet-rich-fibrin-membrane-as-scaffolds-in-the-apexification-treatment-of-young-permanent-teeth
#4
Madhu Santhakumar, Shivsankar Yayathi, N Retnakumari
Aims: This triple blinded clinical trial was undertaken to check whether Platelet rich firin in its membrane form is as reliable as when it is in the gel form. Settings and Design: Triple blinded randomized clinical trial. Methods and Material: 20 patients in PRF gel group and 20 patients in PRF membrane group selected after randomization and considering inclusion and exclusion criteria were taken up for this study. The samples were clinically and radiographically evaluated for success...
January 2018: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/29601789/comparative-evaluation-of-healing-pattern-after-surgical-excision-of-oral-mucosal-lesions-by-using-platelet-rich-fibrin-prf-membrane-and-collagen-membrane-as-grafting-materials-a-randomized-clinical-trial
#5
Monica Mahajan, Mithilesh Kumar Gupta, Chandrashekhar Bande, Vikas Meshram
PURPOSE: To compare the healing potential of platelet-rich fibrin (PRF) and collagen membranes in oral mucosal healing. MATERIALS AND METHODS: Thirty patients with oral premalignant lesions were randomly included in the study and divided in groups A and B. After excising the lesions under local anesthesia, patients in groups A and B underwent grafting with the PRF membrane and the collagen membrane, respectively. Patients were evaluated at postoperative days 7, 15, 30, and 60 for pain, healing, and complications, such as recurrence, fibrosis, scar hypertrophy, and loss of vestibular depth...
March 8, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29568179/management-of-multiple-recession-defects-in-esthetic-zone-using-platelet-rich-fibrin-membrane-a-36-month-follow-up-case-report
#6
Prabhjeet Singh, Sagrika Shukla, Kuldeep Singh
A patient undergoing orthodontic treatment presented with multiple recession defects in maxillary anterior region. After thorough clinical examination and assessment, measurements were recorded. Maxillary anterior teeth with recession defects of 3-4 mm were treated with coronally advanced flap and platelet-rich fibrin (PRF) membrane. Regular follow-up was maintained for the patient at 3, 6 , 12, 18, 24, 30, and 36 months. After 36 months, significant root coverage of 100 percent was observed in four defects and 50% coverage in one defect...
January 2018: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29568177/multidisciplinary-prognostic-transition-of-a-molar-tooth-for-long-term-survival
#7
Arun Kumar, Ashish Kumar, Komal Puri, Mansi Bansal, Manish Khatri, Puneet Batra
Patients with periodontitis may have one or few teeth with hopeless prognosis, which would have to be extracted before initiation of orthodontic therapy. Periodontal therapy aims to prolong the lifespan of dentition, as preserving natural dentition is always the best treatment option. The decision to retain a tooth is always based on the probability of long-term success of one or more treatment modality. A 17-year-old female patient seeking fixed orthodontic treatment presented with the left mandibular first molar tooth (36) having hopeless periodontal prognosis with advanced primary periodontal and secondary endodontic lesion, grade III mobility, and grade II furcation involvement...
January 2018: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29568172/treatment-of-gingival-recession-by-coronally-advanced-flap-in-conjunction-with-platelet-rich-fibrin-or-resin-modified-glass-ionomer-restoration-a-clinical-study
#8
Sudheer Ramireddy, Jaideep Mahendra, Vijayalakshmi Rajaram, Geetha Ari, Anil Kumar Kanakamedala, Dhanadivya Krishnakumar
Aims: The aim of this study is to compare the outcome of coronally advanced flap (CAF) along with the use of platelet-rich fibrin (PRF) versus CAF in conjunction with a resin-modified glass-ionomer cement (RmGIC) for the management of Millers Class I and Class II gingival recession coupled with noncarious cervical lesions (NCCLs). Materials and Methods: Single and multiple Miller's Class I and Class II gingival recessions were chosen for the study. Twenty participants with total of 78 sites associated with NCCL bilaterally in the anterior and premolar region of maxilla were selected...
January 2018: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29565259/role-of-platelet-rich-fibrin-on-intestinal-anastomosis-wound-healing-in-a-rat
#9
Necdet Özçay, Handan Özdemir, Hasan Besim
OBJECTIVES: The aim of the present study is to investigate the role of platelet rich fibrin(PRF) on the intestinal anastomotic wound healing in a mesenteric ischemia/reperfusion (I/R) rat model. METHODS: Forty male Sprague Dawley rats were allocated into four groups: Group I (n=10) Anastomosis to normal bowel; Group II (n=10) Anastomosis after I/R injury; Group III (n=10) Anastomosis and PRF; Group IV Anastomosis after I/R and PRF. Animals were followed up for 7 days, then sacrificed...
March 22, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/29554700/procoagulant-effects-of-low-level-platelet-activation-and-its-inhibition-by-colchicine
#10
Caroline J Reddel, Gabrielle J Pennings, Jennifer L Curnow, Vivien M Chen, Leonard Kritharides
Platelets play an important role in diseases such as cardiovascular disease and cancer, especially through their release of extracellular vesicles (EVs) and role in thrombosis. The effects of the anti-inflammatory drug colchicine on platelets are not well understood. We investigated the effect of colchicine on the release of pro-coagulant EVs from platelets under low-level activation. Citrated platelet-rich plasma (PRP) from healthy donors was incubated with 2 mM colchicine or vehicle at 37°C for 30 minutes with gentle rotation...
March 19, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29543995/titanium-prepared-platelet-rich-fibrin-provides-advantages-on-periodontal-healing-a-randomized-split-mouth-clinical-study
#11
Taner Arabaci, Mevlut Albayrak
BACKGROUND: The aim of this study to evaluate the contributions of titanium-prepared platelet-rich fibrin (T-PRF) combined with open flap debridement (OFD) on biological markers in gingival crevicular fluid (GCF)and periodontal outcomes. METHODS: Twenty-nine participants with chronic periodontitis were treated either with autologous T-PRF+OFD or OFD alone. GCF growth factor levels and relative receptor activator nuclear factor kappa-B/osteoprotegerin (RANKL/OPG) ratio at baseline and 2, 4, and 6 weeks postoperatively were analyzed, and clinical parameters such as probing depth (PD), relative attachment level (RAL) and gingival margin level (GML) at baseline and 9 months after surgery were compared...
March 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29537945/efficacy-of-platelet-concentrates-in-pulpotomy-a-systematic-review
#12
Roshan Noor Mohamed, Sakeenabi Basha, Yousef Al-Thomali
The main purpose of the present systematic review was to evaluate the efficacy of platelet concentrates in pulpotomy of human teeth. Our systematic search included Medline, Embase, CINAHL, PsycINFO, Scopus, key journals, and review articles; the date of the last search was July 30, 2017. We graded the methodological quality of the studies by Cochrane Risk of Bias tool. Four randomized controlled trails were included in the present systematic review. The number of study participants ranged from 28 to 50, with a mean of 45...
March 14, 2018: Platelets
https://www.readbyqxmd.com/read/29537729/enhancement-of-post-orthodontic-tooth-stability-by-carbonated-hydroxyapatite-incorporated-advanced-platelet-rich-fibrin-in-rabbits
#13
A A Alhasyimi, P P Pudyani, W Asmara, I D Ana
OBJECTIVE: To evaluate the effect of carbonated hydroxyapatite-incorporated advanced platelet-rich fibrin on relapse and bone remodelling in rabbits. MATERIALS AND METHODS: Forty-five rabbits were divided into 3 groups (n = 15): a control group, carbonated hydroxyapatite (CHA) and carbonated hydroxyapatite-incorporated advanced platelet-rich fibrin (CHA-aPRF) group. The lower incisors were subjected to an orthodontic force of 50 cN. During the retention period, CHA and CHA-aPRF hydrogel were gently injected in the mesial gingival sulcus every 7 days...
March 14, 2018: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/29524029/effect-of-platelet-rich-fibrin-palatal-bandage-on-pain-scores-and-wound-healing-after-free-gingival-graft-a-randomized-controlled-clinical-trial
#14
Maha A Bahammam
OBJECTIVE: This prospective randomized clinical trial was conducted to determine whether the application of a platelet-rich fibrin (PRF) palatal bandage after harvesting free gingival grafts (FGG) would improve healing of donor sites and decrease pain scores and patient discomfort. MATERIALS AND METHODS: Twenty-four patients received FGG to augment keratinized tissue dimensions. The application of a PRF bandage was decided randomly (n = 12 in each group). Patients reported their pain levels for the first 7 days of healing using the visual analog scale (VAS), 101-point numerical rating scale (NRS-101), and 4-point verbal rating scale (VRS-4)...
March 9, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29524025/root-end-surgery-with-leucocyte-and-platelet-rich-fibrin-and-an-occlusive-membrane-a-randomized-controlled-clinical-trial-on-patients-quality-of-life
#15
Nastaran Meschi, Steffen Fieuws, Anke Vanhoenacker, Olaf Strijbos, Dominique Van der Veken, Constantinus Politis, Paul Lambrechts
OBJECTIVES: The aim of this study was to investigate the impact of the adjunct of leukocyte- and platelet-rich fibrin (LPRF) to root-end surgery (RES) on the patients' quality of life during the first week post RES. MATERIALS AND METHODS: Patients in need of RES were recruited for an open randomized controlled clinical trial (RCT) with a 2 × 2 factorial design. They were randomly allocated to the test (+LPRF) and control (-LPRF) group. Each group was subsequently divided into two strata: with or without an occlusive membrane (Bio-Gide®, Geistlich Biomaterials, Switzerland; BG)...
March 9, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29509050/a-low-speed-centrifugation-concept-leads-to-cell-accumulation-and-vascularization-of-solid-platelet-rich-fibrin-an-experimental-study-in-vivo
#16
Alica Kubesch, Mike Barbeck, Sarah Al-Maawi, Anna Orlowska, Patrick F Booms, Robert A Sader, Richard J Miron, Charles J Kirkpatrick, Joseph Choukroun, Shahram Ghanaati
Platelet-rich fibrin (PRF) is generated from the patients' own venous blood by a single centrifugation step without the additional use of anticoagulants. Based on the previously described LSCC (low-speed centrifugation concept), our group showed that modification of the centrifugation setting, that is, reducing the relative centrifugal force (RCF) and mildly increasing the centrifugation time, resulted in modified solid and liquid PRF-matrices with increased number of platelets, leukocytes, and growth factors' concentrations...
March 6, 2018: Platelets
https://www.readbyqxmd.com/read/29502702/editorial-commentary-platelet-rich-fibrin-matrix-is-this-stuff-for-real
#17
EDITORIAL
Ajay C Lall, Benjamin G Domb
The use of biologic augments such as platelet-rich plasma and platelet-rich fibrin for tendon pathology has skyrocketed within the past 5-7 years amongst orthopaedic patients. Many retrospective series exist with small sample sizes and variable clinical applications. Patient psyche, price of product, and outcomes may be more intimately related than once thought. In this commentary, we briefly review the placebo and psychometric effect of medicine.
March 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29481504/autologous-bone-marrow-concentrates-and-concentrated-growth-factors-accelerate-bone-regeneration-after-enucleation-of-mandibular-pathologic-lesions
#18
Wael M Talaat, Mohamed M Ghoneim, Omar Salah, Osama A Adly
Stem cell therapy is a revolutionary new way to stimulate mesenchymal tissue regeneration. The platelets concentrate products started with platelet-rich plasma (PRP), followed by platelet-rich fibrin (PRF), whereas concentrated growth factors (CGF) are the latest generation of the platelets concentrate products which were found in 2011. The aim of the present study was to evaluate the potential of combining autologous bone marrow concentrates and CGF for treatment of bone defects resulting from enucleation of mandibular pathologic lesions...
February 23, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29466688/the-efficacy-of-platelet-rich-plasma-and-platelet-rich-fibrin-in-arthroscopic-rotator-cuff-repair-a-meta-analysis-of-randomized-controlled-trials
#19
Eoghan T Hurley, Daren Lim Fat, Cathal J Moran, Hannan Mullett
BACKGROUND: Basic science studies suggest that platelet-rich therapies have a positive effect on tendon repair. However, the clinical evidence is conflicted on whether this translates to increased tendon healing and improved functional outcomes. PURPOSE: To perform a systematic review of randomized controlled trials (RCTs) in the literature to ascertain whether platelet-rich plasma (PRP) or platelet-rich fibrin (PRF) improved patient outcomes in arthroscopic rotator cuff repair...
February 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29465055/evaluation-of-the-effect-of-platelet-rich-fibrin-on-the-alveolar-osteitis-incidence-and-periodontal-probing-depth-after-extracting-partially-erupted-mandibular-third-molars-extraction
#20
H Unsal, G N H Erbasar
Aims: To evaluate whether the alveolar osteitis (AO) incidence after extracting partially erupted third molars differs when platelet-rich fibrin (PRF) is administered in the alveolar socket and to assess the influence of PRF on postoperative pain levels and periodontal probing depth. Settings and Design: In this split-mouth randomized study, 50 patients (17 men/ 33 women; mean age, 23.96 years) with bilateral symmetric partially erupted mandibular third molars were enrolled...
February 2018: Nigerian Journal of Clinical Practice
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