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Platelet rich fibrine

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https://www.readbyqxmd.com/read/28401929/the-effect-of-l-prf-membranes-on-bone-healing-in-rabbit-tibiae-bone-defects-micro-ct-and-biomarker-results
#1
Fernanda Faot, Sanne Deprez, Katleen Vandamme, Germana V Camargos, Nelson Pinto, Jasper Wouters, Joost van den Oord, Marc Quirynen, Joke Duyck
More insight into the biological fundamentals of leukocyte platelet-rich fibrin (L-PRF) guided healing is necessary to recommend its application, in particular in deficient bone sites that need to support implants. This study investigated the short-term bone healing effect of L-PRF treatment in cylindrical non-critical sized bone defects with 3 mm diameter and 6 mm depth in tibiae of 18 adult male New Zealand White rabbits. After a randomization process, 96 bone defects were prepared and half of them were filled with a L-PRF membrane, while untreated defects in the opposite tibia served as control group...
April 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28401197/platelet-rich-fibrin-prf-in-implants-dentistry-in-combination-with-new-bone-regenerative-flapless-technique-evolution-of-the-technique-and-final-results
#2
Antonio Cortese, Giuseppe Pantaleo, Massimo Amato, Candace M Howard, Lorenzo Pedicini, Pier Paolo Claudio
Most common techniques for alveolar bone augmentation are guided bone regeneration (GBR) and autologous bone grafting. GBR studies demonstrated long-term reabsorption using heterologous bone graft. A general consensus has been achieved in implant surgery for a minimal amount of 2 mm of healthy bone around the implant. A current height loss of about 3-4 mm will result in proper deeper implant insertion when alveolar bone expansion is not planned because of the dome shape of the alveolar crest. To manage this situation a split crest technique has been proposed for alveolar bone expansion and the implants' insertion in one stage surgery...
January 2017: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/28393825/a-contemporary-approach-for-treatment-planning-of-horizontally-resorbed-alveolar-ridge-ridge-split-technique-with-simultaneous-implant-placement-using-platelet-rich-fibrin-membrane-application-in-mandibular-anterior-region
#3
Prathahini S Parthiban, R Vijaya Lakshmi, Jaideep Mahendra, K Sreekumar, Ambalavanan Namasivayam
Treatment of edentulous sites with horizontal atrophy represents a clinical situation in which the positioning of endosseous implants might be complex or sometimes impossible without a staged regenerative approach. This case report presents management of horizontally deficient mandibular anterior ridge with a contemporary approach to treatment planning and application of platelet-rich fibrin membrane for ridge split technique and simultaneous implant placement. Implants in anterior mandibular area are considered to be most predictable, stable, with high success rate and patients' satisfaction with implant esthetics...
January 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28388803/cartilage-scales-embedded-in-fibrin-gel
#4
Milos Kovacevic, Frank Riedel, Jochen Wurm, Gregor M Bran
Multiple techniques have been described for dorsal nasal augmentation in rhinoplasty. In this article, we review common surgical techniques for raising the dorsum or eliminating dorsal irregularities, by highlighting inherent advantages and disadvantages of each method. Within the past few years, the use of diced cartilage grafts has become the workhorse in this field of interest. To overcome drawbacks of methods based on diced cartilage, we present a new concept for autologous augmentation, using regenerative medicine protocols...
April 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/28368130/a-novel-technique-in-root-coverage-procedures-the-fibrin-assisted-soft-tissue-promotion-concept
#5
Alexandre-Amir Aalam, Alina Krivitky Aalam, Joseph Choukroun
The goal of periodontal plastic surgery is to correct the soft-tissue deformities associated with the loss of attached and keratinized tissue. A variety of flap manipulations related to the use of subepithelial connective tissue grafts are described with great success in the literature but are linked with morbidity and harvesting-quality issues, inclining clinicians and researchers to find alternatives to such techniques. Advanced platelet-rich fibrin, which is widely used in medicine and oral therapy, represents a newer generation of blood-derived growth factors...
April 2017: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/28358761/histomorphometric-comparison-of-bone-regeneration-in-critical-sized-bone-defects-using-demineralized-bone-matrix-platelet-rich-fibrin-and-hyaluronic-acid-as-bone-substitutes
#6
Alper Sindel, Ömür Dereci, Havva Serap Toru, Sinan Tozoğlu
AIM: To compare bone regeneration in the critical-sized bone defects grafted with demineralized bone matrix, platelet-rich fibrin, and hyaluronic acid in rats. MATERIALS AND METHODS: Forty Wistar Albino rats allocated into 4 experimental groups: platelet-rich fibrin (PRF) group, noncross-linked hyaluronic acid gel (HA) group, demineralized bone matrix in putty form (DBM) group, and control group. A critical-sized defect of 8 mm was formed involving the sagittal suture for each rat under anesthetic induction...
March 29, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28357003/alveolar-ridge-preservation-after-tooth-extraction-with-dfdba-and-platelet-concentrates-a-radiographic-retrospective-study
#7
Behrang Baniasadi, Laurence Evrard
OBJECTIVES: The purpose of this study was to evaluate vertical alveolar bone loss 3 months after tooth extraction when a technique of ridge preservation was applied using a particulate demineralized freeze-dried bone allograft 300 - 500 µm associated with platelet concentrates (platelet-rich-fibrin) in the form of gel and membranes. MATERIAL AND METHODS: A retrospective radiological clinical study was conducted on 56 patients for whom 95 extractions had been performed immediately followed by alveolar filling...
2017: Open Dentistry Journal
https://www.readbyqxmd.com/read/28351189/effects-of-an-injectable-platelet-rich-fibrin-on-osteoblast-behavior-and-bone-tissue-formation-in-comparison-to-platelet-rich-plasma
#8
Xuzhu Wang, Yufeng Zhang, Joseph Choukroun, Shahram Ghanaati, Richard J Miron
Platelet-rich plasma (PRP) has been utilized for many years as a regenerative agent capable of inducing vascularization of various tissues using blood-derived growth factors. Despite this, drawbacks mostly related to the additional use of anti-coagulants found in PRP have been shown to inhibit the wound healing process. For these reasons, a novel platelet concentrate has recently been developed with no additives by utilizing lower centrifugation speeds. The purpose of this study was therefore to investigate osteoblast behavior of this novel therapy (injectable-platelet-rich fibrin; i-PRF, 100% natural with no additives) when compared to traditional PRP...
March 29, 2017: Platelets
https://www.readbyqxmd.com/read/28324162/reduction-of-relative-centrifugal-forces-increases-growth-factor-release-within-solid-platelet-rich-fibrin-prf-based-matrices-a-proof-of-concept-of-lscc-low-speed-centrifugation-concept
#9
K El Bagdadi, A Kubesch, X Yu, S Al-Maawi, A Orlowska, A Dias, P Booms, E Dohle, R Sader, C J Kirkpatrick, J Choukroun, S Ghanaati
Purpose The present study evaluated the platelet distribution pattern and growth factor release (VEGF, TGF-β1 and EGF) within three PRF (platelet-rich-fibrin) matrices (PRF, A-PRF and A-PRF+) that were prepared using different relative centrifugation forces (RCF) and centrifugation times. Materials and methods immunohistochemistry was conducted to assess the platelet distribution pattern within three PRF matrices. The growth factor release was measured over 10 days using ELISA. Results The VEGF protein content showed the highest release on day 7; A-PRF+ showed a significantly higher rate than A-PRF and PRF...
March 21, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28302625/silencing-of-anticoagulant-protein-c-evokes-low-incident-but-spontaneous-atherothrombosis-in-apolipoprotein-e-deficient-mice
#10
Amber B Ouweneel, Marco Heestermans, Robin A F Verwilligen, Marion J J Gijbels, Pieter H Reitsma, Miranda van Eck, Bart J M van Vlijmen
OBJECTIVE: Murine atherosclerosis models do not spontaneously develop atherothrombotic complications. We investigated whether disruption of natural anticoagulation allows preexisting atherosclerotic plaques to progress toward an atherothrombotic phenotype. APPROACH AND RESULTS: On lowering of plasma protein C levels with small interfering RNA (siProc) in 8-week Western-type diet-fed atherosclerotic apolipoprotein E-deficient mice, one out of 4 mice displayed a large, organized, and fibrin- and leukocyte-rich thrombus on top of an advanced atherosclerotic plaque located in the aortic root...
March 16, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28295124/evaluation-of-the-effect-of-platelet-rich-fibrin-on-long-bone-healing-an-experimental-rat-model
#11
Turan Cihan Dülgeroglu, Hasan Metineren
Pseudoarthrosis, or nonunion, of the long bones is a challenging medical condition for orthopedic surgeons to treat. Therefore, healing enhancer materials are commonly used. The authors investigated whether platelet-rich fibrin accelerates long bone healing by comparing radiological and histological findings in a rat model of open femoral fracture. Platelet-rich fibrin is a current biomaterial that contains many growth factors and platelets. There are no studies in the literature investigating the effects of platelet-rich fibrin on fracture healing...
March 14, 2017: Orthopedics
https://www.readbyqxmd.com/read/28294200/four-year-post-loading-results-of-full-arch-rehabilitation-with-immediate-placement-and-immediate-loading-implants-a-retrospective-controlled-study
#12
Alain Simonpieri, Roberta Gasparro, Giuseppe Pantaleo, Jolanda Mignogna, Francesco Riccitiello, Gilberto Sammartino
OBJECTIVES: The aim of this study was to evaluate implant survival rate and to measure peri-implant bone changes in fullarch rehabilitations with immediate placement and immediate loading implants with platform switching and Morse taper connection, in addition to platelet-rich fibrin (PRF) and buccal bone augmentation, after 4 years of follow-up. METHOD AND MATERIALS: In this retrospective controlled study, patients who had been fully rehabilitated with immediate placement and immediate loading implants were evaluated 4 years post-loading...
March 14, 2017: Quintessence International
https://www.readbyqxmd.com/read/28283682/reduction-of-relative-centrifugation-force-within-injectable-platelet-rich-fibrin-prf-concentrates-advances-patients-own-inflammatory-cells-platelets-and-growth-factors-the-first-introduction-to-the-low-speed-centrifugation-concept
#13
J Choukroun, S Ghanaati
PURPOSE: The aim of this study was to analyze systematically the influence of the relative centrifugation force (RCF) on leukocytes, platelets and growth factor release within fluid platelet-rich fibrin matrices (PRF). MATERIALS AND METHODS: Systematically using peripheral blood from six healthy volunteers, the RCF was reduced four times for each of the three experimental protocols (I-III) within the spectrum (710-44 g), while maintaining a constant centrifugation time...
March 10, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28277063/quantification-of-growth-factors-in-different-platelet-concentrates
#14
Jing Qiao, Na An, Xiangying Ouyang
Concentrated growth factor (CGF), a new generation of platelet concentrate product, appears to have more abundant growth factors because of its special centrifugation process. However, there are few studies supporting this. This study was designed to evaluate the contents of major growth factors in CGF and compare them with those found in PRP (platelet-rich plasma) and PRF (platelet-rich fibrin). PRP, PRF, and CGF were obtained from the same samples of peripheral blood. Concentrations of five representative growth factors in platelets were measured with enzyme-linked immunosorbent assay (ELISA): platelet-derived growth factor-BB (PDGF-BB), transforming growth factor β-1 (TGF-β1), insulin-like growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF)...
February 21, 2017: Platelets
https://www.readbyqxmd.com/read/28273236/three-dimensional-structure-and-cytokine-distribution-of-platelet-rich-fibrin
#15
Meng-Yi Bai, Ching-Wei Wang, Jyun-Yi Wang, Ming-Fang Lin, Wing P Chan
OBJECTIVES: Previous reports have revealed that several cytokines (including platelet-derived growth factor-BB, transforming growth factors-β1 and insulin-like growth factor-1) can enhance the rate of bone formation and synthesis of extracellular matrix in orthopaedics or periodontology. This study aimed to determine the concentration of cytokines within platelet-rich fibrin microstructures and investigate whether there are differences in the different portions of platelet-rich fibrin, which has implications for proper clinical use of platelet-rich fibrin gel...
February 1, 2017: Clinics
https://www.readbyqxmd.com/read/28258712/leucocyte-and-platelet-rich-fibrin-probably-enhances-healing-after-intrabony-and-furcation-defects-surgery
#16
Romina Brignardello-Petersen
No abstract text is available yet for this article.
March 1, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28251561/platelet-rich-fibrin-prepared-from-stored-whole-blood-samples
#17
Kazushige Isobe, Masashi Suzuki, Taisuke Watanabe, Yutaka Kitamura, Taiji Suzuki, Hideo Kawabata, Masayuki Nakamura, Toshimitsu Okudera, Hajime Okudera, Kohya Uematsu, Koh Nakata, Takaaki Tanaka, Tomoyuki Kawase
BACKGROUND: In regenerative therapy, self-clotted platelet concentrates, such as platelet-rich fibrin (PRF), are generally prepared on-site and are immediately used for treatment. If blood samples or prepared clots can be preserved for several days, their clinical applicability will expand. Here, we prepared PRF from stored whole-blood samples and examined their characteristics. METHODS: Blood samples were collected from non-smoking, healthy male donors (aged 27-67 years, N = 6), and PRF clots were prepared immediately or after storage for 1-2 days...
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28250739/platelet-rich-plasma-an-adjuvant-biological-therapy-to-assist-peripheral-nerve-repair
#18
REVIEW
Mikel Sánchez, Ane Garate, Diego Delgado, Sabino Padilla
Therapies such as direct tension-free microsurgical repair or transplantation of a nerve autograft, are nowadays used to treat traumatic peripheral nerve injuries (PNI), focused on the enhancement of the intrinsic regenerative potential of injured axons. However, these therapies fail to recreate the suitable cellular and molecular microenvironment of peripheral nerve repair and in some cases, the functional recovery of nerve injuries is incomplete. Thus, new biomedical engineering strategies based on tissue engineering approaches through molecular intervention and scaffolding offer promising outcomes on the field...
January 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28249808/potential-for-osseous-regeneration-of-platelet-rich-fibrin-a-comparative-study-in-mandibular-third-molar-impaction-sockets
#19
Mathew P Varghese, Suvy Manuel, Surej Kumar L K
PURPOSE: This study investigated the potential of platelet-rich fibrin (PRF) for osseous regeneration and soft tissue healing in mandibular third molar impaction sockets. MATERIALS AND METHODS: A prospective in vivo study was performed. Randomization was performed after extraction. On one side, the socket was sutured primarily (control site); on the other side, autologous PRF gel was placed and then the socket was sutured (test site). Postoperatively, grid periapical radiographs were obtained at periodic intervals (weeks 1, 4, and 16) and digitalized...
February 4, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28236425/efficacy-of-platelet-rich-fibrin-after-mandibular-third-molar-extraction-a-systematic-review-and-meta-analysis
#20
REVIEW
Faez Saleh Al-Hamed, Mohamed Abdel-Monem Tawfik, Ehab Abdelfadil, Mohammed A Q Al-Saleh
PURPOSE: To assess the effect of platelet-rich fibrin (PRF) on the healing process of the alveolar socket after surgical extraction of the mandibular third molars. MATERIALS AND METHODS: PubMed, the Cochrane Central Register of Controlled Trials, Scopus, and relevant journals were searched using a combination of specific keywords ("platelet-rich fibrin," "oral surgery," and "third molar"). The final search was conducted on November 2, 2015. Randomized controlled clinical trials, as well as controlled clinical trials, aimed at comparing the effect of PRF versus natural healing after extraction of mandibular third molars were included...
February 1, 2017: Journal of Oral and Maxillofacial Surgery
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