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Platelet rich fibrine

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https://www.readbyqxmd.com/read/27915981/molecular-cellular-and-pharmaceutical-aspects-of-autologous-grafts-for-peri-implant-hard-and-soft-tissue-defects
#1
Jiayu Lu, Yongming Hao, Wei Zhao, Chengqi Lv, Derong Zou
The lack of supporting hard and soft tissues always prevents the rehabilitation with dental implants. Among various hard and soft tissue augmentation procedures, autologous grafts have been considered to be the gold standard. Autologous mesenchymal stem cells (MSCs) from bone marrow, dental tissue and adipose tissue have been described as promising alternatives for bone regeneration in the field of dental implantation. Mucosal cells, gingival fibroblasts and dental progenitor cells (DPS) can enhance peri-implant soft tissue augmentation and regenerate periodontal tissues around dental implants...
December 1, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27900247/use-of-autologous-platelet-rich-fibrin-in-osseous-regeneration-after-cystic-enucleation-a-clinical-study
#2
Manzoor Dar, Tajamul Hakim, Ajaz Shah, Latief Najar, Gowhar Yaqoob, Faiqah Lanker
AIMS AND OBJECTIVES: The aim of this study was to evaluate the efficacy of PRF in osseous regeneration after enucleation of cystic lesions. The objectives of this study were as follows: (1) to evaluate osseous regeneration radiographically with the use of PRF in intrabony defects after cystic enucleation. (2) To evaluate the degree of bone density in intrabony defects with the use of PRF postoperatively after 1st, 3rd, and 6th months. SUBJECTS AND METHODS: 20 cases of cystic lesions were treated using PRF after cystic enucleation...
November 2016: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/27891638/regenerative-potential-of-leucocyte-and-platelet-rich-fibrin-l-prf-part-b-sinus-floor-elevation-alveolar-ridge-preservation-and-implant-therapy-a-systematic-review
#3
REVIEW
Ana B Castro, Nastaran Meschi, Andy Temmerman, Nelson Pinto, Paul Lambrechts, Wim Teughels, Marc Quirynen
AIM: To analyse the effect of Leucocyte- and Platelet Rich Fibrin (L-PRF) on bone regeneration procedures and osseointegration. MATERIALS AND METHODS: An electronic and hand search was conducted in three databases (MEDLINE, EMBASE and Cochrane). Only randomised clinical trials, written in English where L-PRF was applied in bone regeneration and implant procedures, were selected. No follow-up restrictions were applied. RESULTS: A total of 14 articles were included and processed...
November 28, 2016: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/27875512/single-tooth-osteotomy-combined-wide-linear-corticotomy-under-local-anesthesia-for-correcting-anterior-protrusion-with-ectopically-erupted-canine
#4
Nur Serife Iskenderoglu, Byung-Joon Choi, Kyung Won Seo, Yeon-Ji Lee, Baek-Soo Lee, Seong-Hun Kim
BACKGROUNDS: This article presents the alternative surgical treatments of both anterior protrusion by carrying out retraction on mandibular anterior fragment, meanwhile applying retraction force on maxilla anterior teeth and ectopically erupted canine with using platelet-rich fibrin (PRF). METHODS: Anterior segmental osteotomy was combined with linear corticotomy under local anesthesia. The correction of right ectopic canine was achieved through 2 stages. First, dento-osseous osteotomy on palatal side was performed...
November 21, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27857762/scaffolds-in-regenerative-endodontics-a-review
#5
REVIEW
Kinjal M Gathani, Srinidhi Surya Raghavendra
Root canal therapy has enabled us to save numerous teeth over the years. The most desired outcome of endodontic treatment would be when diseased or nonvital pulp is replaced with healthy pulp tissue that would revitalize the teeth through regenerative endodontics. 'A search was conducted using the Pubmed and MEDLINE databases for articles with the criteria 'Platelet rich plasma', 'Platelet rich fibrin', 'Stem cells', 'Natural and artificial scaffolds' from 1982-2015'. Tissues are organized as three-dimensional structures, and appropriate scaffolding is necessary to provide a spatially correct position of cell location and regulate differentiation, proliferation, or metabolism of the stem cells...
September 2016: Dental Research Journal
https://www.readbyqxmd.com/read/27853485/study-on-the-efficacy-of-platelet-rich-fibrin-matrix-in-hair-follicular-unit-transplantation-in-androgenetic-alopecia-patients
#6
Sandeep Mahapatra, Dhruva Kumar, Vignesh Subramanian, Swarup K Chakrabarti, Kaushik D Deb
Objective: Hair loss is a significant problem worldwide. The most common cause of hair loss in men is male androgenetic alopecia, male pattern baldness, which is primarily due to the presence of nonfunctional or dead hair follicles in the scalp. Hair follicular unit transplantation has been a widely used technique to transplant hair follicles into bald areas. Although follicular unit transplantation generally gives satisfactory hair transplantation, efforts have been made to further increase the efficacy of follicular unit transplantation in hair regeneration...
September 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27853331/effects-of-platelet-rich-plasma-platelet-rich-fibrin-with-and-without-stromal-cell-derived-factor-1-on-repairing-full-thickness-cartilage-defects-in-knees-of-rabbits
#7
Soghra Bahmanpour, Maryam Ghasemi, Mohsen Sadeghi-Naini, Iraj Ragerdi Kashani
BACKGROUND: The purpose of this study was to create biomaterial scaffolds like platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) containing stromal cell-derived factor-1 (SDF1) as a chemokine to induce hyaline cartilage regeneration of rabbit knee in a full thickness defect. METHODS: We created a full thickness defect in the trochlear groove of thirty-six bilateral knees of eighteen mature male rabbits. The knees were randomly divided into six groups (group I: untreated control, group II: PRP, group III: PRF, group IV: Gelatin+SDF1, group V: PRP+SDF1, and group VI: PRF+SDF1)...
November 2016: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27845852/platelet-rich-plasma-a-source-of-autologous-growth-factors-and-biomimetic-scaffold-for-peripheral-nerve-regeneration
#8
Mikel Sánchez, Eduardo Anitua, Diego Delgado, Peio Sanchez, Roberto Prado, Gorka Orive, Sabino Padilla
In mammals, axons of injured peripheral nerves (PNI) can and do regenerate, but often the functional recovery is incomplete or suboptimal. In recent years, in vivo tissue engineering approaches through molecular intervention and scaffolding are offering promising outcomes. Evidence is accumulating in both preclinical and clinical settings indicating that platelet rich plasma (PRP) and fibrin scaffolds obtained from this technology hold an important adjuvant therapeutic potential. Areas covered: This review addresses current molecular and cellular data in intrinsic nerve repair processes and describes different strategies to harness and enhance these processes by using biochemical and biomechanical cues...
November 15, 2016: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/27837344/platelet-rich-fibrin-may-reduce-the-risk-of-delayed-recovery-in-tooth-extracted-patients-undergoing-oral-bisphosphonate-therapy-a-trial-study
#9
Takuya Asaka, Noritaka Ohga, Yutaka Yamazaki, Jun Sato, Chiharu Satoh, Yoshimasa Kitagawa
OBJECTIVES: The aim of the present study was to evaluate the effectiveness of platelet-rich fibrin (PRF) as a wound-healing accelerator in patients undergoing oral bisphosphonate therapy and requiring tooth extractions. MATERIALS AND METHODS: A total of 102 patients were divided into a PRF group and control group. The patients received oral bisphosphonate therapy for osteoporosis for an average of 32 months. Blood was collected and PRF was introduced into the socket of the PRF group only...
November 11, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27829743/role-of-plasma-rich-fibrin-in-oral-surgery
#10
REVIEW
K Retna Kumar, K Genmorgan, S M Abdul Rahman, M Alaguvel Rajan, T Arul Kumar, V Srinivas Prasad
Platelet-rich fibrin (PRF) is a fibrin meshwork, in which platelet cytokines, growth factors, and cells are entrapped and discharged after a period and can serve as a resorbable film. PRF is the next generation of platelet concentrates equipped to improve arrangement without biochemical blood handling; PRF is an evolution of the fibrin adhesive, which is widely used in the oral surgery. The guidelines of this innovation depend on concentrating platelets and growth factors in a plasma medium, and initiating them in a fibrin gel, keeping in mind the end goal to enhance the healing of wounds...
October 2016: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/27806763/-use-of-alveolar-bone-mucosa-periosteal-bone-flap-in-dental-implantation
#11
P Xu, X N Li, Xhy Xu, Y N Cheng, D Yu, L Y Lu
To introduce a method of increasing the width of alveolar bone. The patient, who needed dental implantation and had narrow alveolar bone, was selected. The preparation of mucosa-periosteal bone flap included two surgeries. The first surgery was corticotomy, which made a square cortex cut on narrow alveolar bone region. The second surgery was performed four weeks after the first one, which split the alveolar bone and inserted implants. Artificial bone and/or autologous bone was filled between inner and outer bone plate, and collagen membrane and platelet-rich fibrin membrane were used to cover the wound...
November 9, 2016: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/27795860/sinus-augmentation-by-platelet-rich-fibrin-alone-a-report-of-two-cases-with-histological-examinations
#12
Naofumi Aoki, Takeo Kanayama, Michinori Maeda, Koichiro Horii, Hironori Miyamoto, Keinoshin Wada, Yasutaka Ojima, Tsukasa Tsuchimochi, Yasuyuki Shibuya
In sinus floor augmentation of an atrophic posterior maxilla, platelet-rich fibrin (PRF) has been used as a graft material. We herein report two cases with histological evaluations of PRF after the surgery. The first case was a 28-year-old female with an atrophic right posterior maxilla who was treated with sinus floor augmentation and simultaneous implant placement using PRF as the sole graft material in our hospital. Twenty-four months after surgery, the implant was unfortunately removed because of occlusal overloading by parafunctional habits...
2016: Case Reports in Dentistry
https://www.readbyqxmd.com/read/27792740/pdlim7-regulates-arf6-dependent-actin-dynamics-and-is-required-for-platelet-mediated-thrombosis-in-mice
#13
Alexander E Urban, Erin O Quick, Kaylie P Miller, Jennifer Krcmery, Hans-Georg Simon
Upon vessel injury, platelets become activated and rapidly reorganize their actin cytoskeleton to adhere to the site of endothelial damage, triggering the formation of a fibrin-rich plug to prevent further blood loss. Inactivation of Pdlim7 provides the new perspective that regulation of actin cytoskeletal changes in platelets is dependent on the encoded PDZ-LIM protein. Loss-of-function of Pdlim7 triggers hypercoagulopathy and causes significant perinatal lethality in mice. Our in vivo and in vitro studies reveal that Pdlim7 is dynamically distributed along actin fibers, and lack of Pdlim7 leads to a marked inability to rearrange the actin cytoskeleton...
2016: PloS One
https://www.readbyqxmd.com/read/27788772/a-new-method-to-develop-human-dental-pulp-cells-and-platelet-rich-fibrin-complex
#14
Xuan He, Wen-Xia Chen, Guifei Ban, Wei Wei, Jun Zhou, Wen-Jin Chen, Xian-Yu Li
INTRODUCTION: Platelet-rich fibrin (PRF) has been used as a scaffold material in various tissue regeneration studies. In the previous methods to combine seed cells with PRF, the structure of PRF was damaged, and the manipulation time in vitro was also increased. The objective of this in vitro study was to explore an appropriate method to develop a PRF-human dental pulp cell (hDPC) complex to maintain PRF structure integrity and to find out the most efficient part of PRF. METHODS: The PRF-hDPC complex was developed at 3 different time points during PRF preparation: (1) the before centrifugation (BC) group, the hDPC suspension was added to the venous blood before blood centrifugation; (2) the immediately after centrifugation (IAC) group, the hDPC suspension was added immediately after blood centrifugation; (3) the after centrifugation (AC) group, the hDPC suspension was added 10 minutes after blood centrifugation; and (4) the control group, PRF without hDPC suspension...
November 2016: Journal of Endodontics
https://www.readbyqxmd.com/read/27783851/regenerative-potential-of-leucocyte-and-platelet-rich-fibrin-l-prf-part-a-intrabony-defects-furcation-defects-and-periodontal-plastic-surgery-a-systematic-review-and-meta-analysis
#15
REVIEW
Ana B Castro, Nastaran Meschi, Andy Temmerman, Nelson Pinto, Paul Lambrechts, Wim Teughels, Marc Quirynen
AIM: To analyse the regenerative potential of leucocyte- and platelet-rich fibrin (L-PRF) during periodontal surgery. MATERIALS AND METHODS: An electronic and hand search were conducted in three databases. Only randomized clinical trials were selected and no follow-up limitation was applied. Pocket depth (PD), clinical attachment level (CAL), bone fill, keratinized tissue width (KTW), recession reduction and root coverage (%) were considered as outcome. When possible, meta-analysis was performed...
October 26, 2016: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/27768215/refixation-allograft-and-adjuvant-cell-therapy-to-treat-nonunion-of-the-femoral-neck-in-a-child
#16
Marina Magnani, Giovanni Trisolino, Stefano Stilli
INTRODUCTION: Idiopathic posttraumatic nonunion is a rare condition in children; the treatment of this complication is still controversial in this peculiar population. CASE REPORT: We report a case of a subcapital type II femoral neck fracture, in a 12-year-old boy, which was initially treated by internal fixation and subsequently went on to a nonunion at the femoral neck, in absence of infection or other disease.1 year after index surgery we performed surgical debridement and refixation with plate and bone allograft, added with autologous bone marrow aspiration concentrate (BMAC) and platelet-rich fibrin (PRF)...
October 15, 2016: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/27763975/effect-of-platelet-rich-fibrin-on-peripheral-nerve-regeneration
#17
Fatma Şenses, Mustafa E Önder, Ismail D Koçyiğit, Oğuz Kul, Gülümser Aydin, Elem Inal, Fethi Atil, Umut Tekin
PURPOSE: This study aimed to evaluate the effect of platelet-rich fibrin (PRF) on peripheral nerve regeneration on the sciatic nerve of rats by using functional, histopathologic, and electrophysiologic analyses. MATERIALS AND METHODS: Thirty female Wistar rats were divided randomly into 3 experimental groups. In group 1 (G1), which was the control group, the sciatic nerve was transected and sutured (n = 10). In group 2 (G2), the sciatic nerve was transected, sutured, and then covered with PRF as a membrane (n = 10)...
October 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27761092/clinical-and-histologic-evaluation-of-platelet-rich-fibrin-accelerated-epithelization-of-gingival-wound
#18
Mansi Bansal, Ashish Kumar, Komal Puri, Manish Khatri, Geeti Gupta, Hitesh Vij
The foremost indication for gingival depigmentation is patient demand for improved aesthetics. In most cases after the removal of pigmented layer, the area is covered with periodontal packs. These dressings have no curative properties. They only minimise the likelihood of surface trauma during mastication. However, platelet-rich fibrin (PRF) accelerates wound healing by effective neovascularisation and promoting fast cicatricial tissue remodelling. In the present split mouth study, PRF membrane was applied in the first quadrant and non-eugenol dressing (Coe-Pack) in the second quadrant after depigmentation...
July 2016: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/27749008/compaction-of-fibrin-clots-reveals-the-antifibrinolytic-effect-of-factor-xiii-comment
#19
V Gurewich
The interesting article on the antifibrinolytic effect of Factor XIII by Rijken et al [1] was predicated on the assumption that fibrinolysis is mediated only by tPA, since that is what was studied. However, there is evidence that this common assumption should be put into question. In a study published almost thirty years ago, we showed that whereas spontaneous lysis of platelet poor plasma clots was mediated by tPA, that of platelet-rich plasma clots, with which this article was concerned, could not be abolished by tPA antibody, but instead was abolished by the addition of uPA antibody...
October 17, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27747711/growth-factor-and-pro-inflammatory-cytokine-contents-in-platelet-rich-plasma-prp-plasma-rich-in-growth-factors-prgf-advanced-platelet-rich-fibrin-a-prf-and-concentrated-growth-factors-cgf
#20
Hideo Masuki, Toshimitsu Okudera, Taisuke Watanebe, Masashi Suzuki, Kazuhiko Nishiyama, Hajime Okudera, Koh Nakata, Kohya Uematsu, Chen-Yao Su, Tomoyuki Kawase
BACKGROUND: The development of platelet-rich fibrin (PRF) drastically simplified the preparation procedure of platelet-concentrated biomaterials, such as platelet-rich plasma (PRP), and facilitated their clinical application. PRF's clinical effectiveness has often been demonstrated in pre-clinical and clinical studies; however, it is still controversial whether growth factors are significantly concentrated in PRF preparations to facilitate wound healing and tissue regeneration. To address this matter, we performed a comparative study of growth factor contents in PRP and its derivatives, such as advanced PRF (A-PRF) and concentrated growth factors (CGF)...
December 2016: Int J Implant Dent
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