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Platelet rich fibrine

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https://www.readbyqxmd.com/read/29026693/platelet-rich-fibrin-a-paradigm-in-periodontal-therapy-a-systematic-review
#1
REVIEW
Umesh Pratap Verma, Rakesh Kumar Yadav, Manisha Dixit, Abhaya Gupta
Periodontal tissue regeneration has always been a challenge for the periodontists owing to its structural complexity. Although with tissue engineering as a growing multidisciplinary field, this aim has partially been fulfilled. In recent years, platelet-rich fibrin (PRF) has gained wide attention for its utilization as a biocompatible regenerative material not only in dental but also in medical fields. The following systematic review has gathered all the currently available in vitro, animal, and clinical studies utilizing PubMed electronic database from January 2006 to August 2016 highlighting PRF for soft and hard tissue regeneration and/or wound healing...
September 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/29023611/adjunctive-effect-of-autologous-platelet-rich-fibrin-in-the-treatment-of-intrabony-defects-in-localized-aggressive-periodontitis-patients-a-randomized-controlled-split-mouth-clinical-trial
#2
ManojKumar Thorat, Om N Baghele, Rakhewar P S
The aim of this study was to investigate the clinical and radiologic efficacy of autologous platelet-rich fibrin (PRF) in the treatment of intrabony defects associated with localized aggressive periodontitis (LAP). A total of 30 sites, 2 sites per individual in 15 LAP patients, were treated with modified flap operation (MFO; Kirkland flap) alone or combined with autologous PRF. The study variables included plaque index, sulcus bleeding index, probing depth (PD), clinical attachment level (CAL), and gingival marginal level at baseline and 12 months postoperatively...
November 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29017535/the-leucopatch%C3%A2-system-in-the-management-of-hard-to-heal-diabetic-foot-ulcers-study-protocol-for-a-randomised-controlled-trial
#3
Frances Game, William Jeffcoate, Lise Tarnow, Florence Day, Deborah Fitzsimmons, Judith Jacobsen
BACKGROUND: Diabetic foot ulcers are a common and severe complication of diabetes mellitus. Standard treatment includes debridement, offloading, management of infection and revascularisation where appropriate, although healing times may be long. The LeucoPatch® device is used to generate an autologous platelet-rich fibrin and leucocyte wound dressing produced from the patient's own venous blood by centrifugation, but without the addition of any reagents. The final product comprises a thin, circular patch composed predominantly of fibrin together with living platelets and leucocytes...
October 10, 2017: Trials
https://www.readbyqxmd.com/read/28990126/effectiveness-and-predictability-of-titanium-prepared-platelet-rich-fibrin-for-the-management-of-multiple-gingival-recessions
#4
Bilge Cansu Uzun, Esra Ercan, Mustafa Tunalı
OBJECTIVE: Titanium-prepared platelet-rich fibrin (T-PRF) is activated with titanium, which results in a more mature and aggregated form than PRF. In our previous studies, we established that the fibrin carpet formed with titanium had a firmer network structure, and longer resorption time in the tissue than the fibrin carpet formed with glass. The purpose of this randomized controlled clinical trial is to compare the effects of autogenous T-PRF and connective tissue graft (CTG). MATERIALS AND METHODS: A total of 114 Miller Class I/II gingival recessions with abrasion defects were treated either T-PRF (63 teeth) or CTG (51 teeth) using a modified tunnel technique...
October 8, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28986682/efficacy-and-safety-of-pleurodesis-using-platelet-rich-plasma-and-fibrin-glue-in-management-of-postoperative-chylothorax-after-esophagectomy
#5
Daryoush Hamidi Alamdari, Mehdi Asadi, Ahmad Nejad Rahim, Ghodratollah Maddah, Shahariar Azizi, Soudabeh Shahidsales, Mostafa Mehrabibahar
INTRODUCTION: Chylothorax is by definition a collection of lymphatic fluids in the pleural cavity because of leakage from main thoracic duct or its tributaries. It is an uncommon but serious postoperative complication in esophageal cancer patients. There is no standard therapeutic algorithm for chylothorax because no prospective or randomized trials have yet been performed to evaluate the available treatment options. The aim of this study was to evaluate the efficacy of pleurodesis with a combination of platelet-rich plasma (PRP) and fibrin glue to the treatment of chylothorax after trans-hiatal esophagectomy...
October 6, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28981200/soluble-fibrin-causes-an-acquired-platelet-glycoprotein-vi-signaling-defect-implications-for-coagulopathy
#6
Mei Yan Lee, Christopher C Verni, Bradley A Herbig, Scott L Diamond
BACKGROUND: In coagulopathic blood, circulating thrombin may drive platelet dysfunction. METHODS/RESULTS: Using calcium dye-loaded platelets, the effect of thrombin exposure and soluble fibrin generation on subsequent platelet GPVI function was investigated. Exposure of apixaban-treated platelet-rich plasma (12% PRP) to thrombin (1-10 nM), but not ADP or thromboxane mimetic U46619 exposure, dramatically blocked subsequent GPVI activation by convulxin, collagen-related peptide, or fibrillar collagen...
October 5, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28978136/nanofat-derived-stem-cells-with-platelet-rich-fibrin-improve-facial-contour-remodeling-and-skin-rejuvenation-after-autologous-structural-fat-transplantation
#7
Hua Wei, Shi-Xing Gu, Yi-Dan Liang, Zhi-Jie Liang, Hai Chen, Mao-Guang Zhu, Fang-Tian Xu, Ning He, Xiao-Juan Wei, Hong-Mian Li
Traditional autologous fat transplantation is a common surgical procedure for treating facial soft tissue depression and skin aging. However, the transplanted fat is easily absorbed, reducing the long-term efficacy of the procedure. Here, we examined the efficacy of nanofat-assisted autologous fat structural transplantation. Nanofat-derived stem cells (NFSCs) were isolated, mechanically emulsified, cultured, and characterized. Platelet-rich fibrin (PRF) enhanced proliferation and adipogenic differentiation of NFSCs in vitro...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28976904/application-of-platelet-rich-fibrin-and-injectable-platelet-rich-fibrin-in-combination-of-bone-substitute-material-for-alveolar-ridge-augmentation-a-case-report
#8
Ivan L Chenchev, Vasilena V Ivanova, Deyan Z Neychev, Radka B Cholakova
BACKGROUND: Different barrier membranes and augmentation techniques are used in oral surgery to recover lost bone structures with varied success. Recently, a combination between bone graft materials and Platelet-Rich-Fibrin (PRF) is implemented in the periodontology and implantology. AIM: The aim of this case report was to assess the possibility for augmentation of the alveolar ridge in the frontal region of the upper jaw, utilizing a combination of bone graft material, injectable platelet-rich-fibrin (i-PRF) and advanced platelet-rich fibrin (A-PRF)...
September 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28969268/comparative-evaluation-of-platelet-rich-fibrin-and-dehydrated-amniotic-membrane-for-the-treatment-of-gingival-recession-a-clinical-study
#9
Ankita Jain, Gagan Rajesh Jaiswal, Kanteshwari Kumathalli, Rajesh Kumar, Alisha Singh, Aakrti Sarwan
INTRODUCTION: The main objective of any therapeutic intervention aimed at root coverage is to restore the tissue margin to the cemento-enamel junction and to regenerate the lost periodontium. AIM: To compare the effectiveness of Platelet Rich Fibrin (PRF) and Amniotic Membrane (AM) in the treatment of gingival recession by Coronally Advanced Flap (CAF) Technique. MATERIALS AND METHODS: Thirty systemically healthy patients who met inclusion-exclusion criteria were selected...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28969191/an-attempt-to-make-platelet-rich-fibrin-from-bone-marrow-aspirate
#10
Soh Nishimoto, Kazutoshi Fujita, Toshihiro Fujiwara, Yohei Sotsuka, Maki Tonooka, Hisako Ishise, Kenichiro Kawai, Masao Kakibuchi
INTRODUCTION: Platelet Rich Fibrin (PRF) was developed as a new generation of platelet concentration from peripheral blood. Method to make PRF is simple. It is easy to handle with its moderate firmness. Histologically, platelets and nucleated cells are packed along the yellow-red border. Bone marrow aspirate contains bone marrow cells that potentially work for tissue regeneration, and platelets which contain growth factors. The specific gravities of them are comparable. It implies that, if it is possible to make PRF from bone marrow aspirate, then high concentration of platelets and bone marrow cells can be obtained simultaneously by taking out yellow-red interface of it...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28965773/an-innovative-regenerative-endodontic-procedure-using-leukocyte-and-platelet-rich-fibrin-associated-with-apical-surgery-a%C3%A2-case%C3%A2-report
#11
Nelson Pinto, Alexandra Harnish, Carolina Cabrera, Catherine Andrade, Tony Druttman, Claudia Brizuela
Regenerative endodontic procedures (REPs) associated with apical surgery could represent an alternative treatment strategy for patients whose teeth present incomplete root formation and extensive apical lesions. Leukocyte platelet-rich fibrin (L-PRF) has potential benefits in REPs; it could promote apical root formation and optimal bone healing. The aim of this case report was to describe innovative regenerative endodontic therapy using L-PRF in the root canal and an extensive apical lesion in an immature tooth with dens invaginatus and asymptomatic apical periodontitis...
September 28, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28962529/editor-s-highlight-pulmonary-vascular-thrombosis-in-rats-exposed-to-inhaled-sulfur-mustard
#12
Matthew D McGraw, Christopher M Osborne, Emily J Mastej, Jorge A Di Paola, Dana R Anderson, Wesley W Holmes, Danielle C Paradiso, Rhonda B Garlick, Tara B Hendry-Hofer, Raymond C Rancourt, Russell W Smith, Carol Burns, Gates B Roe, Jacqueline S Rioux, Carl W White, Livia A Veress
Sulfur mustard (SM) is a chemical warfare agent. When inhaled, SM causes significant injury to the respiratory tract. Although the mechanism involved in acute airway injury after SM inhalation has been well described previously, the mechanism of SM's contribution to distal lung vascular injury is not well understood. We hypothesized that acute inhalation of vaporized SM causes activated systemic coagulation with subsequent pulmonary vascular thrombi formation after SM inhalation exposure. Sprague Dawley rats inhaled SM ethanolic vapor (3...
October 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28960933/autologous-bioscaffolds-based-on-different-concentrations-of-platelet-rich-plasma-and-synovial-fluid-as-a-vehicle-for-mesencymal-stem-cells
#13
Ane Garate, Pello Sánchez, Diego Delgado, Ane Miren Bilbao, Emma Muiños-López, Froilán Granero-Moltó, Gorka Orive, Felipe Prosper, José Luis Pedraz, Mikel Sánchez
In the field of tissue engineering, diverse types of bioscaffolds are being developed currently for osteochondral defect applications. In this work, a novel scaffold based on Platelet Rich Plasma and hyaluronic acid with Mesenchymal stem cells (MSCs) has been evaluated to observe its effect on immobilized cells. The bio-scaffolds were prepared by mixing different volumes of synovial fluid (SF) with Platelet Rich Plasma (PRP) from patients obtaining 3 formulations at PRP-SF ratios of 3:1, 1:1 and 1:3 (vol/vol)...
September 27, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28958140/platelet-rich-fibrin-in-the-management-of-medication-related-osteonecrosis-of-the-jaw-a-clinical-and-histopathological-evaluation
#14
F Inchingolo, S Cantore, G Dipalma, I Georgakopoulos, M Almasri, E Gheno, A Motta, M Marrelli, D Farronato, A Ballini, A Marzullo
Bisphosphonates are antiresorptive pharmacological agents used in the treatment of osteoporosis. Recently, osteonecrosis of the jaw has been recognized as a potential side effect in patients on long-term bisphosphonate therapy. This condition, popularly called bisphosphonate-related osteonecrosis of the jaw (BRONJ), has been rechristened as MRONJ (medication-related osteonecrosis of the jaw) to accommodate the increasing number of cases of osteonecrosis of jaws associated with various other antiresorptive and antigiogenic pharmacological therapies...
July 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28956535/evaluation-of-peri-implant-tissues-around-nanopore-surface-implants-with-or-without-platelet-rich-fibrin-a-clinico-radiographic-study
#15
Zia Arshad Khan, Rajesh Jhingran, Vivek Kumar Bains, Ruchi Srivastava, Rohit Madan, Iram Rizvi
To comparatively evaluate peri-implant tissue changes around nano-pore implant surface with or without platelet rich fibrin (PRF). Material and Methods: For the present study total number of 17 patients was initially enrolled for the study (6 females, 11 males) with 38 sites (19 control and 19 experimental sites) were finally randomly assigned to receive either as Group 1 (Control) i.e. Extraction site received immediate implants without any PRF, and Group 2 (Experimental) i.e. Extraction sites received immediate implants with PRF...
September 28, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28936298/the-role-of-leucocyte-rich-and-platelet-rich-fibrin-l-prf-in-the-treatment-of-the-medication-related-osteonecrosis-of-the-jaws-mronj
#16
REVIEW
Jorge A Cano-Durán, Juan-Francisco Peña-Cardelles, Daniel Ortega-Concepción, Víctor M Paredes-Rodríguez, Mariano García-Riart, Juan López-Quiles
BACKGROUND: For the treatment of the bisphosphonates and other drugs related osteonecrosis of the jaws, currently medication-related osteonecrosis of the jaws (MRONJ), have been established different conservative therapeutic approaches, avoiding surgery except in cases of extreme need. Given the controversy and lack of current consensus regarding MRONJ therapy in patients, new techniques have been developed among which the use of fibrin membranes rich in platelets and leukocytes (L-PRF)...
August 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28931468/platelet-released-growth-factors-inhibit-proliferation-of-primary-keratinocytes-in-vitro
#17
Andreas Bayer, Mersedeh Tohidnezhad, Rouven Berndt, Sebastian Lippross, Peter Behrendt, Tim Klüter, Thomas Pufe, Holger Jahr, Jochen Cremer, Franziska Rademacher, Maren Simanski, Regine Gläser, Jürgen Harder
Autologous thrombocyte concentrate lysates as platelet-released growth factors (PRGF) or Vivostat Platelet Rich Fibrin (PRF(®)) represent important tools in modern wound therapy, especially in the treatment of chronic, hard-to-heal or infected wounds. Nevertheless, underlying cellular and molecular mechanisms of the beneficial clinical effects of a local wound therapy with autologous thrombocyte concentrate lysates are poorly understood. Recently, we have demonstrated that PRGF induces antimicrobial peptides in primary keratinocytes and accelerates keratinocytes' differentiation...
September 18, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28926988/quality-assessment-of-platelet-rich-fibrin-like-matrix-prepared-from-whole-blood-samples-after-extended-storage
#18
Hideo Kawabata, Kazushige Isobe, Taisuke Watanabe, Toshimitsu Okudera, Masayuki Nakamura, Masashi Suzuki, Jietsu Ryu, Yutaka Kitamura, Hajime Okudera, Kazuhiro Okuda, Koh Nakata, Tomoyuki Kawase
The platelet-rich fibrin-like matrix (PRFM) is usually prepared onsite and immediately used for regenerative therapy. Nonetheless, to meet the clinical necessity of preserving the PRFM without quality deterioration, we developed a method for preparation of PRFMs from short-term-stored whole blood (WB) samples. In this study, to evaluate the practical expiration date of storage, we extended the storage time of WB samples from 2 to 7 days and assessed the quality of the resulting PRFMs. WB samples collected with acid-citrate-dextrose were stored with gentle agitation at ambient temperature...
September 18, 2017: Biomedicines
https://www.readbyqxmd.com/read/28914251/clinical-and-radiographic-comparison-of-platelet-rich-fibrin-and-mineral-trioxide-aggregate-as-pulpotomy-agents-in-primary-molars
#19
Surendra Patidar, Namita Kalra, Amit Khatri, Rishi Tyagi
AIM: This study aimed to evaluate and compare the Platelet-rich fibrin (PRF) and Mineral trioxide aggregate (MTA) as a pulpotomy agent in primary molars. MATERIAL AND METHODS: In this study, 50 primary molars from 50 healthy children aged 5-9 years requiring pulpotomy were randomly allocated into two groups. In PRF group, after coronal pulp removal and hemostasis, remaining pulp tissue was covered with PRF preparation. In the MTA group, the pulp stumps were covered with MTA (Pro Root MTA-Root Canal Repair Material, Dentsply International Inc...
October 2017: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/28893718/alternatives-to-connective-tissue-graft-in-the-treatment-of-localized-gingival-recessions-a-systematic-review
#20
K Amine, Y El Amrani, S Chemlali, J Kissa
AIM: The aim of this Systematic Review (SR) was to assess the clinical efficacy of alternatives procedures; Acellular Dermal Matrix (ADM), Xenogeneic Collagen Matrix (XCM), Enamel Matrix Derivative (EMD) and Platelet Rich Fibrin (PRF), compared to conventional procedures in the treatment of localized gingival recessions. MATERIAL AND METHODS: Electronic searches were performed to identify randomized clinical trials (RCTs) on treatment of single gingival recession with at least 6 months of follow-up...
September 9, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
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