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Platelet rich fibrine

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https://www.readbyqxmd.com/read/29240523/injectable-platelet-rich-fibrin-using-the-low-speed-centrifugation-concept-improves-cartilage-regeneration-when-compared-to-platelet-rich-plasma
#1
Mustafa Abd El Raouf, Xuzhu Wang, Si Miusi, Jihua Chai, Abdel Basit Mohamed AbdEl-Aal, Mekkawy M Nefissa Helmy, Shahram Ghanaati, Joseph Choukroun, Elisa Choukroun, Yufeng Zhang, Richard J Miron
The aim of the present study was to evaluate the effect of injectable platelet-rich fibrin (i-PRF) on cultivated chondrocytes and osteochondral regeneration in critical-sized osteochondral defect of the rabbit's knee in comparison to autologous platelet-rich plasma (PRP). Chondrocytes were first investigated for their ability to proliferate and differentiate in response to PRP and i-PRF. Thereafter, full-thickness critical-sized osteochondral defects 5 mm in diameter and 5 mm in depth were created in the knee joint of 12 adult female New Zealand White rabbits...
December 14, 2017: Platelets
https://www.readbyqxmd.com/read/29235312/basics-of-platelet-rich-fibrin-therapy
#2
Richard J Miron, Mark Bishara, Joseph Choukroun
No abstract text is available yet for this article.
April 2017: Dentistry Today
https://www.readbyqxmd.com/read/29215443/scaffold-free-bone-regeneration-using-platelet-rich-fibrin-in-calvarial-defect-model
#3
Yeo Reum Jeon, Mi Jung Kim, Yong Oock Kim, Tai Suk Roh, Won Jai Lee, Eun Hye Kang, In Sik Yun
Bone regeneration is a complex process influenced by various physiological factors. Platelet-rich plasma (PRP) contains many growth factors and has shown osteogenic effects. The PRP is usually activated before use. However, the authors showed that nonactivated PRP (nPRP) and activated PRP have comparable osteogenic effects in the previous study. Generally, a scaffold has been needed for the application of PRP in the cranial defect model. In this study, the authors aimed to compare the performance of scaffold free platelet-rich fibrin (PRF) to nPRP as an adjuvant for bone regeneration...
December 6, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29209937/sugar-based-collagen-membrane-cross-linking-increases-barrier-capacity-of-membranes
#4
Po-Ju Chia-Lai, Anna Orlowska, Sarah Al-Maawi, Andre Dias, Yunxin Zhang, Xuejiu Wang, Niklas Zender, Robert Sader, C James Kirkpatrick, Shahram Ghanaati
OBJECTIVES: This study examines the permeability and barrier capacity of a sugar cross-linked resorbable collagen membrane ex vivo and in vivo. MATERIALS AND METHODS: In an ex vivo study, injectable platelet-rich fibrin (i-PRF), a peripheral blood-derived human leukocyte-and-platelet-rich plasma was used to analyze membrane permeability. in vivo subcutaneous implantation in Wistar rats (n = 4 per time point and group) was used to investigate the barrier capacity of the membrane...
December 6, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29207216/the-roles-of-cellular-and-molecular-components-of-a-hematoma-at-early-stage-of-bone-healing
#5
REVIEW
Hoi Ting Shiu, Ping Chung Leung, Chun Hay Ko
Bone healing is a complex repair process which commences with formation of a blood clot at the injured bone, termed hematoma. It has evidenced that a lack of a stable hematoma causes delayed bone healing or non-union. The hematoma at the injured bone constitutes the early healing microenvironment. It appears to dictate healing pathways which ends in a regenerative bone. However, the hematoma is often clinically removed from the damaged site. Conversely, blood-derived products have been used in bone tissue engineering for treating critical sized defects (CSDs), including fibrin gels and platelet rich plasma...
December 5, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29197444/a-leukocyte-and-platelet-rich-fibrin-showed-a-regenerative-potential-in-intrabony-defects-and-furcation-defects-but-not-in-periodontal-plastic-surgery
#6
Zuhair S Natto, Martyn S Green
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Regenerative potential of leucocyte- and platelet-rich fibrin. Part A: intra-bony defects, furcation defects and periodontal plastic surgery. A systematic review and meta-analysis. Castro AB, Meschi N, Temmerman A, Pinto N, Lambrechts P, Teughels W, Quirynen M. J Clin Periodontol 2017; 44(1):67-82. SOURCE OF FUNDING: Self-funded by the authors and their institution TYPE OF STUDY/DESIGN: Systematic review with meta-analysis of data...
December 2017: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/29194267/evaluating-of-platelet-rich-fibrin-in-the-treatment-of-alveolar-cleft-with-iliac-bone-graft-by-means-of-volumetric-analysis
#7
Nesrin Saruhan, Umit Ertas
The purpose of this study was to evaluate the efficiency of platelet-rich fibrin usage in the treatment of alveolar cleft with iliac bone graft by means of volumetric analysis. In this study, 22 patients with alveolar clefts-including 13 unilateral and 9 bilateral-were treated with anterior iliac crest bone grafts. Patients were divided into 2 groups as control (group A) and platelet-rich fibrin (group B) groups. Cone beam computed tomography (CBCT) scans were obtained preoperatively and 6 months postoperatively...
November 20, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29186946/use-of-autologous-bone-marrow-cells-concentrate-enriched-with-platelet-fibrin-on-extensor-mechanism-allograft-reconstruction-for-extensor-mechanism-failure-following-total-knee-arthroplasty
#8
S Giannotti, P D Parchi, G B Colasanti, G Agostini, F Moreschini, C Cataldi, P Ferrata, R Capanna
Allografts techniques remain the best reconstructive strategy for chronic extensor mechanism lesions after total knee arthroplasty (3) but outcomes depend strictly on the host tissue-allograft junctions healing. The purpose of this study is to evaluate if modern techniques of adding autologous bone marrow cells concentrate enriched with platelet-rich fibrin, provide better healing of the allograft. We present the case of an 86 years old patient affected by patellar tendon rupture after TKA. A whole extensor mechanism allograft was performed adding a bone marrow cells concentrate enriched with platelet-rich fibrin on the host tissue-allograft junctions...
October 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29181461/platelet-rich-fibrin-with-bone-grafts-for-regeneration-of-bony-defect-following-extraction-of-supernumerary-teeth-a-case-report
#9
Balamanikandasrinivasan Chandrasekaran, Nanditha Suresh, Senthilkumar Muthusamy
Supernumerary teeth are hyperdontic variants due to abnormalities during tooth development. Here, we report a case on regeneration of bony defect, which ensued following extraction of two supernumerary teeth in the mandibular premolar region, using a combination of bone grafts and platelet-rich fibrin. To the best of our knowledge, it is the first time synergistic use of biomaterials with bone grafts have been used for this type of management.
2017: Chinese Journal of Dental Research
https://www.readbyqxmd.com/read/29146168/bone-marrow-derived-mesenchymal-stromal-cells-enhanced-by-platelet-rich-plasma-maintain-adhesion-to-scaffolds-in-arthroscopic-simulation
#10
Alexander R Hoberman, Carl Cirino, Mary Beth McCarthy, Mark P Cote, Leo Pauzenberger, Knut Beitzel, Augustus D Mazzocca, Felix Dyrna
PURPOSE: To assess the response of bone marrow-derived mesenchymal stromal cells (bMSCs) enhanced by platelet-rich plasma (PRP) in the setting of a normal human tendon (NHT), a demineralized bone matrix (DBM), and a fibrin scaffold (FS) with simulated arthroscopic mechanical washout stress. METHODS: Bone marrow was aspirated from the humeral head and concentrated. BMSCs were counted, plated, and grown to confluence. Cells were seeded onto 3 different scaffolds: (1) NHT, (2) DBM, and (3) FS...
November 13, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29126543/platelet-rich-fibrin-added-to-graft-may-increase-bone-defect-fill-in-intrabony-defects-9-months-after-graft-placement
#11
Romina Brignardello-Petersen
No abstract text is available yet for this article.
November 3, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/29125132/chitosan-inhibits-platelet-mediated-clot-retraction-increases-platelet-derived-growth-factor-release-and-increases-residence-time-and-bioactivity-of-platelet-rich-plasma-in-vivo
#12
Gabrielle Deprés-Tremblay, Anik Chevrier, Nicolas Tran-Khanh, Monica Nelea, Michael D Buschmann
Platelet-rich plasma (PRP) has been used to treat different orthopedic conditions, however, the clinical benefits of using PRP remain uncertain. Chitosan (CS)-PRP implants have been shown to improve meniscus, rotator cuff and cartilage repair in pre-clinical models. The purpose of this current study was to investigate in vitro and in vivo mechanisms of action of CS-PRP implants. Freeze-dried formulations containing 1% (w/v) CS (80% degree of deacetylation and number average molar mass 38 kDa), 1% (w/v) trehalose as a lyoprotectant and 42...
November 10, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/29114283/a-method-for-reconstruction-of-severely-damaged-spinal-cord-using-autologous-hematopoietic-stem-cells-and-platelet-rich-protein-as-a-biological-scaffold
#13
Ahmed Sabry Ammar, Yasser Osman, Ahmed Taher Hendam, Mohammed Ahmed Hasen, Fatma Abdullah Al Rubaish, Danya Yaagoub Al Nujaidi, Faisal Mishal Al Abbas
Introduction: There have been attempts to alter the prognosis of severe spinal cord injury in different centers, but none of which have reliably altered the outcome. Some trials use stem cells (SCs) that produced widely differing results. We hereby add our experience in our center of a surgical reconstruction of the damaged spinal cord using a mixture of SCs and Platelet-Rich Protein (PRP) with fibrin coated as a biological scaffold. Materials and Methods: Four cases of severely damaged spinal cord have been operated for neurolysis and reconstruction of the spinal cord using SCs and platelet-rich protein (PRP) with fibrin coated harvested from the peripheral circulation of the patient...
October 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29080077/effects-of-single-and-double-layered-resorbable-membranes-and-platelet-rich-fibrin-on-bone-healing
#14
Mert Tayşi, Berkem Atalay, Burak Çankaya, Sami Yıldırım
OBJECTIVES: Research has been ongoing on achieving optimum bone healing in the reconstruction of bone loss. Clinically, soft tissue migration into the already existing bone defects is the leading cause of unfavourable bone healing. Platelet-rich fibrin, a recent material that is used to promote bone healing, was compared with single- and double-layered resorbable collagen membranes to determine whether a healing protocol which increases patient comfort is possible. MATERIALS AND METHODS: Sixty adult female Sprague-Dawley rats were used...
October 27, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29079056/large-periapical-or-cystic-lesions-in-association-with-roots-having-open-apices-managed-nonsurgically-using-1-step-apexification-based-on-platelet-rich-fibrin-matrix-and-biodentine-apical-barrier-a-case-series
#15
Sarang Sharma, Vivek Sharma, Deepak Passi, Dhirendra Srivastava, Shibani Grover, Shubha Ranjan Dutta
Teeth having open apices in the absence of a natural apical constriction pose several challenges during conventional endodontic treatment, especially when establishing an apical seal. Treatment is further challenging when these teeth are associated with large periapical or cystic lesions having resulted in expansion and/or thinning of adjacent cortical plates. Although surgical intervention is commonly adopted in the management of such cases, a conservative treatment option offering equally good prognosis is always desirable...
October 24, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29072215/modified-lateral-positioned-flap-with-platelet-rich-fibrin-graft-for-treatment-of-denuded-root-surfaces-a-clinical-study
#16
Abhishek Ashok Kurdukar, Priyanka Abhishek Kurdukar, Nitin Hemchandra Dani
BACKGROUND: Root coverage (RC) procedures such as lateral positioned flap (LPF) have been used since long time but with limited success and specific indications. AIM: This prospective clinical study was designed to evaluate clinically the effect of modified LPF (mLPF) with platelet-rich fibrin (PRF) graft for the treatment of denuded root surfaces. MATERIALS AND METHODS: Fifteen isolated Miller's Class I and II gingival recession of single-rooted teeth were selected for the study...
September 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/29071440/reduction-of-the-relative-centrifugal-force-influences-cell-number-and-growth-factor-release-within-injectable-prf-based-matrices
#17
Simon Wend, Alica Kubesch, Anna Orlowska, Sarah Al-Maawi, Niklas Zender, Andre Dias, Richard J Miron, Robert Sader, Patrick Booms, C James Kirkpatrick, Joseph Choukroun, Shahram Ghanaati
Platelet rich fibrin (PRF) is a blood concentrate system obtained by centrifugation of peripheral blood. First PRF matrices exhibited solid fibrin scaffold, more recently liquid PRF-based matrix was developed by reducing the relative centrifugation force and time. The aim of this study was to systematically evaluate the influence of RCF (relative centrifugal force) on cell types and growth factor release within injectable PRF- in the range of 60-966 g using consistent centrifugation time. Numbers of cells was analyzed using automated cell counting (platelets, leukocytes, neutrophils, lymphocytes and monocytes) and histomorphometrically (CD 61, CD- 45, CD-15+, CD-68+, CD-3+ and CD-20)...
October 25, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29059116/management-of-failed-rotator-cuff-repair-in-young-patients
#18
Bassem T Elhassan, Ryan M Cox, Dave R Shukla, Julia Lee, Anand M Murthi, Robert Z Tashjian, Joseph A Abboud
Management of failed rotator cuff repair may be difficult, especially in young patients. Various nonmodifiable and modifiable patient factors, including age, tendon quality, rotator cuff tear characteristics, acute or chronic rotator cuff tear, bone quality, tobacco use, and medications, affect rotator cuff repair healing. Surgical variables, such as the technique, timing, tension on the repair, the biomechanical construct, and fixation, as well as the postoperative rehabilitation strategy also affect rotator cuff repair healing...
November 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29058984/impact-of-histological-thrombus-composition-on-preinterventional-thrombus-migration-in-patients-with-acute-occlusions-of-the-middle-cerebral-artery
#19
Christian Maegerlein, Benjamin Friedrich, Maria Berndt, Kristin Elizabeth Lucia, Lucas Schirmer, Holger Poppert, Claus Zimmer, Jaroslav Pelisek, Tobias Boeckh-Behrens, Johannes Kaesmacher
Purpose The occurrence of thrombus migration (TM) in middle cerebral arteries (MCAs) prior to mechanical thrombectomy (MT) in patients suffering from acute ischemic strokes is a crucial aspect as TM is associated with lower rates of complete reperfusion and worse clinical outcomes. In this study, we sought to clarify whether histological thrombus composition influences TM. Methods We included 64 patients with acute MCA occlusions who had undergone MT. In 11 of the cases (17.2%) we identified TM prior to the interventions...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/29058084/clinical-evaluation-of-coronally-advanced-flap-with-or-without-platelet-rich-fibrin-for-the-treatment-of-multiple-gingival-recessions
#20
Samed Kuka, Sebnem Dirikan Ipci, Gokser Cakar, Selcuk Yılmaz
OBJECTIVES: The aim of this randomized, controlled study was to assess the clinical effect of platelet-rich fibrin (PRF) in combination with coronally advanced flap (CAF) on root coverage, esthetics, and patient satisfaction when compared to CAF alone for the treatment of multiple Miller class I recessions. MATERIALS AND METHODS: A total of 24 patients with 52 Miller class I multiple recessions ≥ 3 mm were included and divided into CAF + PRF and CAF groups. At baseline and 12 months after surgery, recession height (RH), keratinized tissue height, gingival thickness (GT), and mean and complete defect coverage were evaluated...
October 20, 2017: Clinical Oral Investigations
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