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https://www.readbyqxmd.com/read/28732133/ionization-and-collision-induced-dissociation-of-steroid-bis-glucuronides
#1
Argitxu Esquivel, Xavier Matabosch, Aristotelis Kotronoulas, Georgina Balcells, Jesús Joglar, Rosa Ventura
Studies on steroid metabolism are of utmost importance to improve the detection capabilities of anabolic androgenic steroids (AAS) misuse in sports drug testing. In humans, glucuronoconjugates are the most abundant phase II metabolites of AAS. Bis-glucuronidation is a reaction where two separated functional groups on the same molecule are conjugated with glucuronic acid. These metabolites have not been studied in depth for steroids and could be interesting markers for doping control. The aim of the present work was to study the ionization and collision induced dissociation of steroid bis-glucuronides to be able to develop mass spectrometric analytical strategies for their detection in urine samples after AAS administration...
July 21, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28731587/reversible-pressure-controlled-depolymerization-of-a-copper-ii-containing-coordination-polymer
#2
Jack Kay Clegg, Aidan Brock, Katrina Jolliffe, Simon Parsons, Leonard Lindoy, Peter Tasker, Fraser White
A unique pressure-induced Cu-N bond breaking/bond forming reaction is reported. The variation of pressure on a single crystal of a one-dimensional copper(II)-containing coordination polymer (Cu2L2(1-methylpiperazine)2]n, where H2L is 1,1'-(1,3-phenylene)-bis(4,4-dimethylpentane-1,3-dione)), was monitored using single crystal X-ray diffraction with the aid of a diamond anvil cell. At a very low elevated pressure (~0.05 GPa) a remarkable reversible phase change was observed. The phase change results in the depolymerization of the material through the cleavage and formation of axial Cu-N bonds as well as "ring flips" of individual axially coordinated 1-methylpiperazine ligands...
July 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28727018/evaluation-of-electrical-broad-bandwidth-impedance-spectroscopy-as-a-tool-for-body-composition-measurement-in-cows-in-comparison-with-body-measurements-and-the-deuterium-oxide-dilution-method
#3
C T Schäff, U Pliquett, A Tuchscherer, R Pfuhl, S Görs, C C Metges, H M Hammon, C Kröger-Koch
Body fatness and degree of body fat mobilization in cows vary enormously during their reproduction cycle and influence energy partitioning and metabolic adaptation. The objective of the study was to test bioelectrical impedance spectroscopy (BIS) as a method for predicting fat depot mass (FDM), in living cows. The FDM is defined as the sum of subcutaneous, omental, mesenteric, retroperitoneal, and carcass fat mass. Bioelectrical impedance spectroscopy is compared with the prediction of FDM from the deuterium oxide (DO) dilution method and from body conformation measurements...
May 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28726673/off-on-fluorescence-monitoring-of-intracellular-ag-in-single-living-cells-using-an-ag-responsive-probe
#4
Jian Lv, Li-Jun Zhao, Ruo-Can Qian, Yi-Tao Long
Detection of silver ions (Ag+) in living cells has becoming more and more attractive due to the important biological impact of Ag+ on cellular functions. Here, we put forward a new approach to realize the in situ fluorescence imaging and detection of Ag+ in single cells via an ultrasensitive Ag+-responsive probe, 3', 6'-bis (diethylamino)-2-(2-iodoethyl) spiro[isoindoline-1, 9'-xanthen]-3-one (BDISIX). In the presence of Ag+, the fluorescence of the probe can be turned "on", generating strong red fluorescence...
July 20, 2017: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/28722448/chemical-sensing-on-a-single-sers-particle
#5
Ying Ma, Kittithat Promthaveepong, Nan Li
We report a new chemical sensing platform on a single surface-enhanced Raman scattering (SERS) particle. A cabbage-like Au microparticle (CLMP) with high SERS enhancement was applied as an ultrasensitive SERS substrate. A new Raman reporter bis[4,4'-[dithiodiphenyl azo-phenol] (DTDPAP) was synthesized to display multiple fingerprints and high reactivity toward sodium dithionite. The reaction of DTDPAP with sodium dithionite was in situ monitored by SERS on a single CLMP. The DTDPAP fingerprint change is dependent on the sodium dithionite concentration, providing a simple and sensitive method for sodium dithionite profiling...
January 27, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28719431/bispectral-index-measurements-are-not-degraded-during-aeromedical-evacuations
#6
Nicolas Donat, Audrey Cirodde, Clément Hoffmann, Jean-Vivien Schaal, Yannick Masson, Antoine Nau, Paul Vincent Martin, Samuel Madec, Thomas Leclerc
For a decade, depth of anesthesia monitoring has become a reality in the operating room. It provides valuable help for managing anesthesia, especially for unstable patients. This might be particularly relevant during aeromedical evacuation. In this study, we aimed to assess the validity of the bispectral index (BIS) during long-range patient transportation aboard fixed-wing aircraft. BIS was recorded in 30 patients, 25 under anesthesia and 5 awake, during aeromedical evacuations performed by the French Air Force...
July 14, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28718959/characterization-of-a-highly-al-3-selective-fluorescence-probe-based-on-naphthalimide-schiff-base-and-its-application-to-practical-water-samples
#7
Kesheng Shen, Shanshan Mao, Xinkui Shi, Fei Wang, Yuling Xu, Stephen Opeyemi Aderinto, Huilu Wu
A new fluorescent Al(3+) -probe, N-allyl-4-[3,3'-((2-aminoethyl)azanediyl)-bis(N´-(2-hydroxybenzylidene)propanehy-drazide)]-1,8-naphthalimide (L), was designed and synthesized based on 1,8-naphthalimide. The probe L contains 1,8-naphthalimide moiety as the fluorophore and a Schiff base as the recognition group. The structure of L was determined by single crystal X-ray. L emission at 526 nm increased on addition of Al(3+) under excitation wavelength at 350 nm. L exhibited high selectivity and sensitivity fluorescence emission towards to Al(3+) in ethanol/Tris-HCl buffer solution (1:1, v/v, pH = 7...
July 18, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28711570/anesthetic-management-of-reversible-cerebral-vasoconstriction-syndrome-a-case-report
#8
Hiroshi Hoshijima, Naoki Itoh, Yoshinori Iwase, Hiroshi Nagasaka
Reversible cerebral vasoconstriction syndrome (RCVS) is a group of disorders characterized by prolonged reversible cerebral vasoconstriction, associated with acute-onset, severe, episodic "thunderclap" headaches with or without other neurologic clinical features. We describe the first reported case, to our knowledge, of a patient with RCVS who was managed under general anesthesia in the field of oral and maxillofacial surgery. A 67-year-old woman with a diagnosis of RCVS made 2 months earlier was scheduled to undergo surgical extraction of the mandibular right third molar...
June 14, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28708306/a-toolbox-of-chromones-and-quinolones-for-measuring-a-wide-range-of-atp-concentrations
#9
Vasyl Georgievich Pivovarenko, Oleksandra Bugera, Nicolas Humbert, Andrey Sergeevich Klymchenko, Yves Mély
A series of 26 3-hydroxychromones, three bis-flavonols and four 3-hydroxyquinolones were studied to evaluate their fluorescence response to interaction with ATP in buffer. The dyes differ by the total charge, the size and number of their aromatic units, as well as the position or electron donating ability of their substituents. All of them were suggested to form complexes with ATP of 1:1 and 1:2 stoichiometry, which can be evidenced by their bright fluorescence and their 3000-6000 cm-1 red-shifted excitation band...
July 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28699007/assessment-of-nonsteroidal-anti-inflammatory-drugs-by-ultrasonic-assisted-extraction-and-gc-ms-in-mgeni-and-msunduzi-river-sediments-kwazulu-natal-south-africa
#10
Bhekumuzi P Gumbi, Brenda Moodley, Grace Birungi, Patrick G Ndungu
The occurrence of eight pharmaceuticals was monitored during four seasons (spring, summer, autumn, and winter) along a 250-km stretch of the Msunduzi and Mgeni rivers in KwaZulu-Natal, South Africa. This paper describes an optimized method for the determination of nonsteroidal anti-inflammatory drugs (NSAIDs) in sediments. The method combines ultrasonic, centrifuge, and gas chromatography-mass spectrometry for the detection of these drugs in solid samples. Most of the parameters that affect the extraction step were optimized...
July 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28697444/an-efficient-electrochemiluminescence-amplification-strategy-via-bis-co-reaction-accelerator-for-sensitive-detection-of-laminin-to-monitor-overnutrition-associated-liver-damage
#11
Jing Zhao, Wen-Bin Liang, Yan-Mei Lei, Yang-Xue Ou, Ya-Qin Chai, Ruo Yuan, Ying Zhuo
With the world wildly improvement in dietary and nutrition status, it couldn't be ignored that the chronic liver disease (CLD) resulted from the overnutrition. In order to estimate nutrition status for healthy living, an efficient and sensitive electrochemiluminescence (ECL) sandwich immunosensor of laminin (LN), a marker of CLD, was proposed for early diagnosis of CLD. In this work, the anodic ECL behavior of perylene derivative using H2O2 as co-reactant was demonstrated and the possible ECL mechanism was proposed...
July 3, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28690194/examining-a-role-for-pkg-i%C3%AE-oxidation-in-the-pathogenesis-of-cardiovascular-dysfunction-during-diet-induced-obesity
#12
Olena Rudyk, Philip Eaton
BACKGROUND: Protein kinase G (PKG) Iα is the end-effector kinase that mediates nitric oxide (NO)-dependent and oxidant-dependent vasorelaxation to maintain blood pressure during health. A hallmark of cardiovascular disease is attenuated NO production, which in part is caused by NO Synthase (NOS) uncoupling, which in turn increases oxidative stress because of superoxide generation. NOS uncoupling promotes PKG Iα oxidation to the interprotein disulfide state, likely mediated by superoxide-derived hydrogen peroxide, and because the NO-cyclic guanosine monophosphate (cGMP) pathway otherwise negatively regulates oxidation of the kinase to its active disulfide dimeric state...
July 6, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28675953/utility-of-nociceptive-flexion-reflex-threshold-and-bispectral-index-to-predict-movement-responses-under-propofol-anaesthesia
#13
Axel Jakuscheit, Matthias J Posch, Stefanos Gkaitatzis, Lisa Neumark, Mark Hackbarth, Martin Schneider, Gregor Lichtner, Jan H Baars, Falk von Dincklage
INTRODUCTION: The nociceptive flexion reflex threshold (NFRT) is a promising tool to monitor analgesia during general anaesthesia. Clinical studies have shown that the NFRT allows to predict movement responses to painful stimuli under a combined anaesthetic regime of sedative and opioid agents. Experimental studies indicated that the NFRT is also able to predict such movement responses under an exclusively sedative regime like propofol mono-anaesthesia. Therefore, we performed this study to investigate the ability of the NFRT to predict movement responses to painful stimuli in patients during a clinical propofol mono-anaesthesia...
July 4, 2017: Somatosensory & Motor Research
https://www.readbyqxmd.com/read/28675522/polymer-fullerene-bimolecular-crystals-for-near-infrared-spectroscopic-photodetectors
#14
Zheng Tang, Zaifei Ma, Antonio Sánchez-Díaz, Sascha Ullbrich, Yuan Liu, Bernhard Siegmund, Andreas Mischok, Karl Leo, Mariano Campoy-Quiles, Weiwei Li, Koen Vandewal
Spectroscopic photodetection is a powerful tool in disciplines such as medical diagnosis, industrial process monitoring, or agriculture. However, its application in novel fields, including wearable and biointegrated electronics, is hampered by the use of bulky dispersive optics. Here, solution-processed organic donor-acceptor blends are employed in a resonant optical cavity device architecture for wavelength-tunable photodetection. While conventional photodetectors respond to above-gap excitation, the cavity device exploits weak subgap absorption of intermolecular charge-transfer states of the intercalating poly[2,5-bis(3-tetradecylthiophen-2-yl)thieno[3,2-b]thiophene] (PBTTT):[6,6]-phenyl-C61-butyric acid methyl ester (PCBM) bimolecular crystal...
July 4, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28674695/minor-immediate-effects-of-a-dog-on-children-s-reading-performance-and-physiology
#15
Lisa Schretzmayer, Kurt Kotrschal, Andrea Beetz
Literacy is a key factor in occupational success and social integration. However, an increasing number of children lack appropriate reading skills. There is growing evidence that dogs have positive effects on reading performance. We investigated the short-term effects of dogs on reading performance in 36 third-graders and monitored physiological parameters [heart rate (HR), heart rate variability (HRV), and salivary cortisol] as well as behavioral variables. Each child took part in two test sessions at the presence of a tutor, in one of which a dog and its handler were present...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28657350/bispectral-index-as-a-predictor-of-unsalvageable-traumatic-brain-injury
#16
Saeed Mahmood, Ayman El-Menyar, Amr Shabana, Ismail Mahmood, Mohammad Asim, Husham Abdelrahman, Hassan Al-Thani
PRIMARY OBJECTIVE: We aimed to assess the utility of bispectral index (BIS) monitoring to diagnose brain death (BD) in patients with severe traumatic brain injury (TBI). RESEARCH DESIGN AND METHODS: A prospective observational study was conducted for patients with severe TBI between 2012 and 2014. MAIN OUTCOMES AND RESULTS: This study included 62 patients with a mean age of 32.5 ± 10.5 years. Nine patients had BD on admission with a sustainable BIS value of 0...
June 28, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28640168/degree-of-postictal-suppression-depends-on-seizure-induction-time-in-magnetic-seizure-therapy-and-electroconvulsive-therapy
#17
Sarah Kayser, Bettina H Bewernick, Martin Soehle, Christina Switala, Sabrina M Gippert, Nadine Dreimueller, Thomas E Schlaepfer
OBJECTIVES: Anesthesia is required for both magnetic seizure therapy (MST) and electroconvulsive therapy (ECT), although it has anticonvulsant properties. In this case, bispectral index (BIS) monitoring, a specific electroencephalogram-derived monitoring, can be used to find the optimal seizure induction time during anesthesia to elicit adequate seizures. A measurement of seizure adequacy in electroencephalogram is the postictal suppression. The purpose of this study was to investigate the influence of seizure induction time on the degree of postictal suppression by comparing BIS versus no-BIS monitoring in MST and ECT...
June 20, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28639673/observing-the-real-time-formation-of-phosphine-ligated-gold-clusters-by-electrospray-ionization-mass-spectrometry
#18
Marshall R Ligare, Grant E Johnson, Julia Laskin
The early stages of reduction and nucleation of ligated gold clusters in solution are largely unknown due, in part, to high reaction rates and the inherent complexity of the process. This study demonstrates that the addition of a diphosphine ligand, 1-4-bis(diphenylphosphino)butane (L(4)) to a methanolic solution of the gold precursor, chloro(triphenylphosphine)gold(I) (Au(PPh3)Cl), results in the initial formation of organometallic complexes of the type [Au(L(4))x(L(4)O)y(PPh3)z](+). These initial complexes lower the rate of gold reduction so that the reaction can be directly monitored over time from 1 min to over an hour using on-line electrospray ionization mass spectrometry (ESI-MS)...
June 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28638473/rapid-fluorescence-imaging-of-spinal-cord-following-epidural-administration-of-a-nerve-highlighting-fluorophore
#19
Wanguo Liu, Rui Gu, Qingsan Zhu, Chunsheng Xiao, Lanfeng Huang, Xinming Zhuang, Jingzhe Zhang, Lidi Liu, Ben Ma, Huailin Yang, Jianchao Ma, Zhipeng Hu, Chenglin Tang, Shuhua Zhao, Xuesi Chen
Iatrogenic spinal cord injury (SCI) is the most devastating complication of spine surgery, which usually results in permanent and serious disabilities of patients. Improvement of the visualization and discrimination of the spinal cord is critical for accuracy and safety during surgery; however, to date, there is no suitable technology to fulfill this clinical need. Here, we first show an efficient and rapid fluorescence imaging of the spinal cord in rabbit by epidural administration of a nerve-highlighting fluorophore, i...
2017: Theranostics
https://www.readbyqxmd.com/read/28631482/carbohydrate-bis-acetal-based-substrates-as-tunable-fluorescence-quenched-probes-for-monitoring-exo-glycosidase-activity
#20
Samy Cecioni, David J Vocadlo
Tunable Förster resonance energy transfer (FRET)-quenched substrates are useful for monitoring the activity of various enzymes within their relevant physiological environments. Development of FRET-quenched substrates for exo-glycosidases, however, has been hindered by their constrained pocket-shaped active sites. Here we report the design of a new class of substrate that overcomes this problem. These Bis-Acetal-Based Substrates (BABS) bear a hemiacetal aglycon leaving group that tethers fluorochromes in close proximity, also positioning them distant from the active site pocket...
June 20, 2017: Journal of the American Chemical Society
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