Laia Peruchet-Noray, Anja M Sedlmeier, Niki Dimou, Hansjörg Baurecht, Béatrice Fervers, Emma Fontvieille, Julian Konzok, Kostas K Tsilidis, Sofia Christakoudi, Anna Jansana, Reynalda Cordova, Patricia Bohmann, Michael J Stein, Andrea Weber, Stéphane Bézieau, Hermann Brenner, Andrew T Chan, Iona Cheng, Jane C Figueiredo, Koldo Garcia-Etxebarria, Victor Moreno, Christina C Newton, Stephanie L Schmit, Mingyang Song, Cornelia M Ulrich, Pietro Ferrari, Vivian Viallon, Robert Carreras-Torres, Marc J Gunter, Heinz Freisling
It remains unknown whether adiposity subtypes are differentially associated with colorectal cancer (CRC). To move beyond single-trait anthropometric indicators, we derived four multi-trait body shape phenotypes reflecting adiposity subtypes from principal components analysis on body mass index, height, weight, waist-to-hip ratio, and waist and hip circumference. A generally obese (PC1) and a tall, centrally obese (PC3) body shape were both positively associated with CRC risk in observational analyses in 329,828 UK Biobank participants (3728 cases)...
April 19, 2024: Science Advances