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https://www.readbyqxmd.com/read/29906660/prevalence-of-cervical-oral-and-anal-human-papillomavirus-infection-in-women-living-with-hiv-in-denmark-the-shade-cohort-study
#1
Kristina Thorsteinsson, Merete Storgaard, Terese L Katzenstein, Steen Ladelund, Frederikke F Rönsholt, Isik Somuncu Johansen, Gitte Pedersen, Anne Gaardsting, Lars Nørregård Nielsen, Jesper Bonde, Anne-Mette Lebech
BACKGROUND: Women living with HIV (WLWH) have elevated risk of human papillomavirus (HPV) related cancers. OBJECTIVES: To assess prevalence, distribution and concordance of cervical, oral, and anal HPV infection, and predictors of oral and anal HPV in WLWH in Denmark. STUDY DESIGN: WLWH followed in the Study on HIV, cervical Abnormalities and infections in women in Denmark (SHADE) were enrolled and examined for cervical, oral, and anal HPV infection...
May 25, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29906522/evaluation-of-venous-thromboembolic-complications-in-patients-operated-on-for-pelvic-fracture
#2
Candice Ostrowka, Stéphanie Bonhomme, Pomme Jouffroy, Guillaume Riouallon
INTRODUCTION: Fractures of the pelvis (acetabulum and pelvic ring) are complex in both radiological diagnosis and therapeutic management. They show high risk of thrombosis, with variable rates of venous thromboembolic complications in the literature, ranging from 10% to 50%, with 0.5-10% risk of fatal pulmonary embolism. The objective of the present study was to determine the rate of venous thromboembolic events in a consecutive cohort of pelvic fracture and to attempt to identify thromboembolic risk factors in this population...
June 12, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29906455/randomized-clinical-trial-of-a-mucoadhesive-formulation-containing-curcuminoids-zingiberaceae-and-bidens-pilosa-linn-asteraceae-extract-fitoprot-for-prevention-and-treatment-of-oral-mucositis-phase-i-study
#3
Edvande Xavier Dos Santos Filho, Diego Antonio Costa Arantes, Angélica Ferreira Oton Leite, Aline Carvalho Batista, Elismauro Francisco de Mendonça, Ricardo Neves Marreto, Letícia Nasser Naves, Eliana Martins Lima, Marize Campos Valadares
Preclinical repeated-dose toxicity and efficiency studies developed by our group suggest the potential of FITOPROT in treating mucositis. This serious limiting side effect is observed at a rate of 40-100% in patients under antineoplastic therapy and despite different palliative measures and therapeutic agents have been investigated, still no therapy was completely successful. Therefore, this study aimed to establish the safety and recommended phase II dose of FITOPROT for the prevention and treatment of chemoradiotherapy-induced oral mucositis (OM) in patients with head and neck cancer...
June 12, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29906435/the-association-of-previous-prostate-biopsy-related-complications-and-the-type-of-complication-with-patient-compliance-with-re-biopsy-scheme
#4
Logan S Schwarzman, Michael R Abern, Daniel F Garvey, Gerald L Andriole, Stephen J Freedland, Daniel M Moreira
INTRODUCTION: Prostate biopsy complications have important consequences that may affect patient compliance with re-biopsy schemes; however, this has not been studied in earnest. Thus, we evaluated whether previous prostate biopsy-related complications and the type of complication were associated with repeat prostate biopsy compliance in a clinical trial with study-mandated systematic biopsies. MATERIALS AND METHODS: Retrospective analysis of 4,939 men ages 50-75 who underwent a 2-year prostate biopsy and were recommended to undergo the 4-year prostate re-biopsy in the Reduction by Dutasteride of prostate cancer Events (REDUCE) study...
June 12, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29906025/malignant-tumors-as-cause-of-disability-at-the-instituto-mexicano-del-seguro-social
#5
Edgar Jesús Zitle-García, Alma Lucila Sauceda-Valenzuela, Iván de Jesús Ascencio-Montiel, Jesús García-Paredes
Background: Cancer represents an important issue in health, with the economic impact that it takes. The aim of this paper is to analyze the epidemiological characteristics of a population with social security who was diagnosed with some type of cancer and required a disability pension. Methods: Observational study, retrolective cohort type, carried out at the Instituto Mexicano del Seguro Social (IMSS) with IMSS beneficiaries ruled with a state of disability due to malignancy during the period 2006 to 2012...
March 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29905928/lactobacillus-plantarum-ar501-alleviates-the-oxidative-stress-of-d-galactose-induced-aging-mice-liver-by-upregulation-of-nrf2-mediated-antioxidant-enzyme-expression
#6
Xiangna Lin, Yongjun Xia, Guangqiang Wang, Zhiqiang Xiong, Hui Zhang, Fengxi Lai, Lianzhong Ai
Lactic acid bacteria (LAB) have been used as ingredients of functional foods to promote health and prevent diseases because of their beneficial effects. This study aimed to investigate the antioxidative effects of LAB on the hepatotoxicity in D-galactose-induced aging mice. LAB were isolated from the traditional Chinese fermented foods and screened by the tolerance of hydrogen peroxide (H2 O2 ). Male ICR (Institute of Cancer Research) mice were subcutaneously injected with D-galactose for 5 weeks and then gastric gavage with LAB for 6 weeks...
June 15, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29905920/breast-cancer-risk-evaluation-by-utilizing-gail-model-and-association-between-breast-cancer-risk-perception-with-early-diagnosis-applications-among-midwives-and-nurses-working-in-primary-health-services
#7
Ebru Turhan, Gokben Yasli
OBJECTIVE: The present study was performed to detect cancer risk of the midwifes and nurses playing central role in raising awareness in the society using Gail's model. MATERIALS AND METHODS: Sample of the present cross sectional study consists of 750 volunteer midwifes and nurses in 2016. Breast cancer risk was calculated using the Gail Risk Assessment Tool. Perceived and calculated risk levels were compared. Descriptive statistics and Chi-Square analysis, t-test, Multivariate Linear Regression Analysis, the Logistic Regression Analysis were conducted...
June 2018: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/29905576/ce-breast-cancer-screening-a-review-of-current-guidelines
#8
Roberta Baron, Karen Drucker, Liza Lagdamen, Maureen Cannon, Carrie Mancini, Erica Fischer-Cartlidge
Recent updates have led to variations in national recommendations. ABSTRACT: Breast cancer accounts for more than a quarter million diagnoses each year in the United States. Routine screening is the primary method used to detect cancer in its earliest stages, before symptoms develop. Recent changes to national screening guidelines have resulted in a lack of consensus and confusion among health care providers and the public. This article reviews the guidelines of the American Cancer Society, the U...
June 13, 2018: American Journal of Nursing
https://www.readbyqxmd.com/read/29905376/a-prospective-study-of-dietary-polyunsaturated-fatty-acids-intake-and-lung-cancer-risk
#9
Hung N Luu, Hui Cai, Harvey J Murff, Yong-Bing Xiang, Qiuyin Cai, Honglan Li, Jing Gao, Gong Yang, Qing Lan, Yu-Tang Gao, Wei Zheng, Xiao-Ou Shu
Animal studies have shown that polyunsaturated fatty acids (PUFAs) have antineoplastic and anti-inflammatory properties. Results from epidemiologic studies on specific types of PUFAs for lung cancer risk, however, are inconclusive. We prospectively evaluated the association of specific types of dietary PUFA intakes and lung cancer risk in two population-based cohort studies, the Shanghai Women's Health Study (SWHS) and Shanghai Men's Health Study (SMHS) with a total of 121,970 study participants (i.e., 65,076 women and 56,894 men)...
June 15, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29905375/sox2-mediated-upregulation-of-cd24-promotes-adaptive-resistance-towards-targeted-therapy-in-melanoma
#10
Laura Hüser, Sachindra, Karol Granados, Aniello Federico, Lionel Larribère, Daniel Novak, Viktor Umansky, Peter Altevogt, Jochen Utikal
Melanoma is often characterized by a constitutively active RAS-RAF-MEK-ERK pathway. For targeted therapy, BRAF inhibitors are available that are powerful in the beginning but resistance occurs rather fast. A better understanding of the mechanisms of resistance is urgently needed to increase the success of the treatment. Here, we observed that SOX2 and CD24 are upregulated upon BRAF inhibitor treatment. A similar upregulation was seen in targeted therapy-resistant, melanoma-derived induced pluripotent cancer cells (iPCCs)...
June 15, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29905313/prevalence-and-risk-factors-for-genital-human-papillomavirus-infections-among-women-in-southwest-nigeria
#11
Y T Nejo, D O Olaleye, G N Odaibo
There is a great variation in the prevalence of cervical HPV infection worldwide with some of the highest rates being found in African women. Early onset of sexual activity (≤ 15 age), multiparity and sexual promiscuity have been recognized as some of the significant risk factors for HPV infection. In Nigeria, there is scarcity of data on the degree of relationship between these factors and the prevalence of HPV infection. Thus, this study was designed to determine the prevalence of genital HPV infection with its potential risk factors among women in Southwest Nigeria...
February 2018: Archives of basic and applied medicine
https://www.readbyqxmd.com/read/29905007/simultaneous-downregulation-of-mir-21-and-mir-155-through-oleuropein-for-breast-cancer-prevention-and-therapy
#12
Maryam Abtin, Mohammad R Alivand, Mahmoud S Khaniani, Milad Bastami, Mohammad Zaeifizadeh, Sima M Derakhshan
Breast cancer (BC) is the leading cause of cancer mortality in women worldwide. It recently was proven that miRNAs play a critical role in BC development. The use of natural agents for control of cancer by modulating miRNAs is promising. Oleuropein is a natural polyphenolic agent with anti-neoplastic properties and is well tolerated by humans. This study was undertaken to determine the therapeutic effects of oleuropein through modulation of master oncomiRs (miR-21 and miR-155) in BC cells. The present study provides the first link between miRNA and oleuropein as a mechanism in BC...
June 15, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29904244/treatment-of-helicobacter-pylori-infection-in-atrophic-gastritis
#13
REVIEW
Edith Lahner, Marilia Carabotti, Bruno Annibale
Helicobacter pylori (Hp) is a major human pathogen causing chronic, progressive gastric mucosal damage and is linked to gastric atrophy and cancer. Hp-positive individuals constitute the major reservoir for transmission of infection. There is no ideal treatment for Hp. Hp infection is not cured by a single antibiotic, and sometimes, a combined treatment with three or more antibiotics is ineffective. Atrophic gastritis (AG) is a chronic disease whose main features are atrophy and/or intestinal metaplasia of the gastric glands, which arise from long-standing Hp infection...
June 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29904176/cancer-prevention-by-aspirin-in-children-with-constitutional-mismatch-repair-deficiency-cmmrd
#14
REVIEW
Erika K S M Leenders, Harm Westdorp, Roger J Brüggemann, Jan Loeffen, Christian Kratz, John Burn, Nicoline Hoogerbrugge, Marjolijn C J Jongmans
Constitutional MisMatch Repair Deficiency (CMMRD) is caused by homozygous or compound heterozygous germline variants in one of the mismatch repair (MMR) genes (MSH2, MSH6, PMS2, MLH1). This syndrome results in early onset colorectal cancer, leukemia and lymphoma, brain tumors and other malignancies. Children with CMMRD are at high risk of developing multiple cancers and cancer surveillance does not guarantee detection of cancer at a curable stage. The development of a preventive treatment strategy would be a major step forward...
June 14, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29904116/neutrophil-tlr4-and-pkr-are-targets-of-breast-cancer-cell-glycosaminoglycans-and-effectors-of-glycosaminoglycan-induced-april-secretion
#15
Uilst Bat-Erdene, Eric Quan, Kelvin Chan, Brianna-Marie Lee, Wejdan Matook, Ki-Young Lee, Jesusa L Rosales
A proliferation-inducing ligand (APRIL), which induces survival and migration signals and tumor growth, is commonly observed in breast cancer tissues but is not often expressed in breast cancer cells themselves. Here, we examined whether breast cancer cells induce APRIL secretion from neutrophils, which are frequently recruited into the breast tumor microenvironment. We found that breast cancer cells do stimulate neutrophils to secrete APRIL through their glycosaminoglycans. Breast cancer cells depleted of heparan sulfate or chondroitin sulfate glycosaminoglycans lose their ability to induce APRIL secretion from neutrophils, and heparan sulfate and chondroitin sulfate can induce secretion that is comparable to that of breast cancer cell-induced secretion...
June 15, 2018: Oncogenesis
https://www.readbyqxmd.com/read/29904102/targeting-prpk-and-topk-for-skin-cancer-prevention-and-therapy
#16
Eunmiri Roh, Mee-Hyun Lee, Tatyana A Zykova, Feng Zhu, Janos Nadas, Hong-Gyum Kim, Ki Beom Bae, Yan Li, Yong Yeon Cho, Clara Curiel-Lewandrowski, Janine Einspahr, Sally E Dickinson, Ann M Bode, Zigang Dong
Solar ultraviolet (sUV) irradiation is a major environmental carcinogen that can cause inflammation and skin cancer. The costs and morbidity associated with skin cancer are increasing, and therefore identifying molecules that can help prevent skin carcinogenesis is important. In this study, we identified the p53-related protein kinase (PRPK) as a novel oncogenic protein that is phosphorylated by the T-LAK cell-originated protein kinase (TOPK). Knockdown of TOPK inhibited PRPK phosphorylation and conferred resistance to solar-simulated light (SSL)-induced skin carcinogenesis in mouse models...
June 14, 2018: Oncogene
https://www.readbyqxmd.com/read/29903796/should-women-aged-70-74-be-invited-to-participate-in-screening-mammography-a-report-on-two-australian-community-juries
#17
Chris Degeling, Alexandra Barratt, Sanchia Aranda, Robin Bell, Jenny Doust, Nehmat Houssami, Jolyn Hersch, Ruben Sakowsky, Vikki Entwistle, Stacy M Carter
OBJECTIVE: To elicit informed views from Australian women aged 70-74 regarding the acceptability of ceasing to invite women their age to participate in government-funded mammography screening (BreastScreen). DESIGN: Two community juries held in 2017. SETTING: Greater Sydney, a metropolis of 4.5 million people in New South Wales, Australia. PARTICIPANTS: 34 women aged 70-74 with no personal history of breast cancer, recruited by random digit dialling and previously randomly recruited list-based samples...
June 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29903744/parents-views-on-the-best-and-worst-reasons-for-guideline-consistent-hpv-vaccination
#18
Melissa B Gilkey, Mo Zhou, Annie-Laurie McRee, Melanie L Kornides, John F P Bridges
Background: Human papillomavirus (HPV) vaccination could prevent most HPV-associated cancers, but few U.S. adolescents are vaccinated according to guidelines. To inform efforts to counsel parents more effectively, we sought to quantify their views on the best and worst reasons for guideline-consistent HPV vaccination. We hypothesized that parents' views would differ according to their vaccination confidence. Methods: We developed a best-worst scaling experiment to evaluate 11 reasons healthcare providers commonly give for HPV vaccination...
June 14, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29903684/environment-cancer-and-inequalities-the-urgent-need-for-prevention
#19
REVIEW
Paolo Vineis, Daniela Fecht
The proportion of total deaths attributable to environmental factors is estimated to be 23% of global deaths and 22% of global disability-adjusted life years (DALYs) according to one review. These estimates encompass all environmental agents including infectious agents but excluding behavioural factors. The authors of the review also estimated that 16% (95% CI: 7-41%) of cancer deaths are attributable to environmental risk factors (and 36% [95% CI: 17-52%] for lung cancer). In this article, we focus on the reasons why epidemiology is often unable to account for the whole burden of environmental carcinogens...
June 11, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29903576/ccr5-established-paradigms-and-new-frontiers-for-a-celebrity-chemokine-receptor
#20
Ilaria Scurci, Elsa Martins, Oliver Hartley
Because of the level of attention it received due to its role as the principal HIV coreceptor, CCR5 has been described as a 'celebrity' chemokine receptor. Here we describe the development of CCR5 inhibitory strategies that have been developed for HIV therapy and which are now additionally being considered for use in HIV prevention and cure. The wealth of CCR5-related tools that have been developed during the intensive investigation of CCR5 as an HIV drug target can now be turned towards the study of CCR5 as a model chemokine receptor...
September 2018: Cytokine
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