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Juvenile traumatic brain injury

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https://www.readbyqxmd.com/read/29066322/alterations-in-mesoscopic-oscillations-affecting-episodic-memory-following-developmental-traumatic-brain-injury
#1
Chaitali Biswas, Dejan Marković, Christopher C Giza
Certain deficits of episodic memory among young adults are the delayed consequences of an earlier mild or moderate Traumatic Brain Injury (mTBI). We examined alterations in hippocampal Local Field Oscillations (LFOs) of equivalently-impaired juvenile rodents to identify reliable functional markers of single-incidence mTBI. Two persistent, behavior-dependent, electrophysiological markers of injury were identified in the absence of external physiological symptoms by the analysis of wirelessly-transmitted hippocampal LFOs (3-80Hz) during repeat measures of the Novel Object Recognition (NOR) paradigm...
October 21, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28802560/traumatic-brain-injuries-during-development-disrupt-dopaminergic-signaling
#2
Kate Karelina, Kristopher R Gaier, Zachary M Weil
Traumatic brain injuries (TBI) sustained during peri-adolescent development produce lasting neuro-behavioral changes that render individuals at an increased risk for developing substance abuse disorders. Experimental and clinical evidence of a prolonged period of hypodopaminergia after TBI have been well documented, but the effect of juvenile TBI on dopaminergic dysfunction and its relationship with substance abuse have not been investigated. In order to determine the effect of juvenile brain injury on dopaminergic signaling, female mice were injured at 21days of age and then beginning seven weeks later were assessed for behavioral sensitization to amphetamine, a drug that increases synaptic dopamine availability...
November 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28685977/the-post-therapeutic-effect-of-rapamycin-in-mild-traumatic-brain-injured-rats-ensuing-in-the-upregulation-of-autophagy-and-mitophagy
#3
Changxing Wang, Zhiying Hu, Yang Zou, Mingjun Xiang, Yuting Jiang, Benson O A Botchway, Xue Huo, Xiaoxue Du, Marong Fang
Mild traumatic brain injury (mTBI), common in juveniles, has been reported to be caused by sports-related concussion. Many young children may suffer from post-concussion syndrome. mTBI, in early stages of life, could play a part in neuron apoptosis and degeneration, cognitive and motor coordination impairment, as well as dementia. Our study was aimed at further investigating the post-therapeutic efficacy of rapamycin in the recuperation of mTBI while at the same time investigating the metamorphosis in both autophagy and mitophagy in mTBI...
September 2017: Cell Biology International
https://www.readbyqxmd.com/read/28625390/dopamine-protects-cerebral-autoregulation-and-prevents-hippocampal-necrosis-after-traumatic-brain-injury-via-block-of-erk-mapk-in-juvenile-pigs
#4
Victor Curvello, Hugh Hekierski, Philip Pastor, Monica S Vavilala, William M Armstead
Traumatic brain injury (TBI) contributes to morbidity in children, and more boys experience TBI. Cerebral autoregulation is impaired after TBI, contributing to poor outcome. Cerebral Perfusion Pressure (CPP) is often normalized by use of vasoactive agents to increase mean arterial pressure (MAP). In prior studies of newborn and juvenile pigs, vasoactive agent choice influenced outcome after TBI as a function of age and sex, with none protecting cerebral autoregulation in both ages and sexes. Dopamine (DA) prevents impairment of cerebral autoregulation in male and female newborn pigs via inhibition of upregulation of ERK mitogen activated protein kinase (MAPK) after fluid percussion injury (FPI)...
September 1, 2017: Brain Research
https://www.readbyqxmd.com/read/28397372/k-channel-impairment-determines-sex-and-age-differences-in-epinephrine-mediated-outcomes-after-brain-injury
#5
William M Armstead, John Riley, Monica S Vavilala
Traumatic brain injury (TBI) is the leading cause of injury-related death in children, with boys and children under 4 years having particularly poor outcomes. Activation of ATP- and calcium-sensitive (KATP and KCa ) channels produces cerebrovasodilation and contributes to autoregulation, both of which are impaired after TBI, contributing to poor outcomes. Upregulation of the c-Jun-terminal kinase (JNK) isoform of mitogen-activated protein kinase produces K channel function impairment after CNS injury. Vasoactive agents can be used to normalize cerebral perfusion pressure...
October 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28355201/sex-and-age-differences-in-phenylephrine-mechanisms-and-outcomes-after-piglet-brain-injury
#6
Victor Curvello, Hugh Hekierski, John Riley, Monica Vavilala, William M Armstead
BackgroundTraumatic brain injury (TBI) is the leading cause of injury-related death in children, with boys and children under 4 years of age having particularly poor outcomes. Cerebral autoregulation is often impaired after TBI, contributing to poor outcome. In prior studies on newborn pigs, phenylephrine (Phe) preferentially protected cerebral autoregulation in female but not in male subjects after TBI. We hypothesized that, in contrast to the newborn, Phe prevents impairment of autoregulation and tissue injury following TBI in both sexes of older pigs...
July 2017: Pediatric Research
https://www.readbyqxmd.com/read/28219086/first-report-of-awake-craniotomy-of-a-famous-musician-suprasellar-tumor-surgery-of-pianist-clara-haskil-in-1942
#7
Elena Romana Gasenzer, Ayhan Kanat, Edmund A M Neugebauer
Clara Haskil (January 7, 1895-December 7, 1960) was one of the most famous female pianists of the 20th century. In her life and work she set new standards in piano playing. However, her career was beset by poor health and the adversities of two world wars. In her lifetime Haskil had three major disorders: juvenile scoliosis requiring treatment in her adolescence, a tumor of the sellar region requiring surgery at age 47 years, and a traumatic brain injury causing her death at the age of 65. Her medical history illustrates the development of surgical methods and rehabilitation in medicine before and after World War II...
May 2017: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/28217290/neuroprotective-effect-of-hyperbaric-oxygen-therapy-in-a-juvenile-rat-model-of-repetitive-mild-traumatic-brain-injury
#8
Lei Huang, Andre Obenaus, Mary Hamer, John H Zhang
Repetitive mild traumatic brain injury (rmTBI) is an important medical concern for adolescent athletes that can lead to long-term disabilities. Multiple mild injuries may exacerbate tissue damage resulting in cumulative brain injury and poor functional recovery. In the present study, we investigated the increased brain vulnerability to rmTBI and the effect of hyperbaric oxygen treatment using a juvenile rat model of rmTBI. Two episodes of mild cortical controlled impact (3 days apart) were induced in juvenile rats...
October 2016: Medical Gas Research
https://www.readbyqxmd.com/read/28127505/traumatic-brain-injury-among-female-offenders-in-a-prison-population-results-of-the-fleurytbi-study
#9
Eric Durand, Laurence Watier, Anne Lécu, Michel Fix, Jean-Jacques Weiss, Mathilde Chevignard, Pascale Pradat-Diehl
AIM: The study was designed to estimate the prevalence of traumatic brain injury (TBI) in a French prison population of female offenders, study the variables known to be associated with TBI, and compare our results with those obtained among male offenders as described in a previous paper. PARTICIPANTS: All female offenders (adults and juveniles) consecutively admitted to Fleury-Mérogis prison over a 3-month period were included in the study. METHOD: During the admission procedure, female offenders were interviewed by healthcare staff using a self-reported questionnaire...
January 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28060202/the-relationship-between-traumatic-brain-injury-and-criminality-in-juvenile-offenders
#10
Wayne A Gordon, Lisa A Spielman, Amanda E Hahn-Ketter, Karla Therese L Sy
OBJECTIVE: To examine the relationship between traumatic brain injury (TBI) and criminal behavior in youth who are incarcerated or on probation in Texas. SETTING: Seven juvenile justice facilities. PARTICIPANTS: Juvenile offenders in state or county correctional facilities or on probation. DESIGN: Screening for TBI was conducted among adolescents at 7 juvenile justice centers. MAIN MEASURES: Participants were administered the Brain Injury Screening Questionnaire, and results were linked to participants' offense history and psychiatric diagnoses...
November 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/27912253/sex-and-age-differences-in-epinephrine-mechanisms-and-outcomes-after-brain-injury
#11
William M Armstead, John Riley, Monica S Vavilala
Traumatic brain injury (TBI) is the leading cause of injury-related death in children, with boys and children <4 years of age having particularly poor outcomes. Cerebral autoregulation is often impaired after TBI, contributing to poor outcome. Cerebral perfusion pressure can be normalized by use of vasoactive agents. The c-Jun-terminal kinase (JNK) isoform of mitogen activated protein kinase (MAPK) produces hemodynamic impairment after TBI, but less is known about its role in histopathology. We investigated whether epinephrine (EPI), age, and sex dependently protected cerebral autoregulation and limited histopathology after TBI, and sought to determine the role of JNK in that outcome...
April 15, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27845195/binge-ethanol-in-adulthood-exacerbates-negative-outcomes-following-juvenile-traumatic-brain-injury
#12
Kate Karelina, Kristopher R Gaier, Maya Prabhu, Vanessa Wenger, Timothy E D Corrigan, Zachary M Weil
Traumatic brain injuries (TBI) are a major public health problem with enormous costs in terms of health care dollars, lost productivity, and reduced quality of life. Alcohol is bidirectionally linked to TBI as many TBI patients are intoxicated at the time of their injury and we recently reported that, in accordance with human epidemiological data, animals injured during juvenile development self-administered significantly more alcohol as adults than did sham injured mice. There are also clinical data that drinking after TBI significantly reduces the efficacy of rehabilitation and leads to poorer long-term outcomes...
February 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27735217/mild-traumatic-brain-injury-produces-long-lasting-deficits-in-synaptic-plasticity-in-the-female-juvenile-hippocampus
#13
Emily R White, Cristina Pinar, Crystal A Bostrom, Alicia Meconi, Brian R Christie
Mild traumatic brain injury (mTBI) is becoming recognized as a significant concern in modern society. In particular, youth is being increasingly seen as a vulnerable time period for mTBI, as this is the final developmental period for the brain and typically involves robust synaptic reorganization and axonal myelination. Another issue that is being hotly debated is whether mTBI differentially impacts the male and female brain. To examine the impact of mTBI in the juvenile brain, we measured hippocampal synaptic plasticity using a closed-head mTBI model in male and female Long-Evans rats (25-28 days of age) at either 1 h, 1 day, 7 days, or 28 days post-injury...
March 1, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27707655/the-juvenile-head-trauma-syndrome-deterioration-after-mild-tbi-diagnosis-and-clinical-presentation-at-the-emergency-department
#14
Angelina R A Pikstra, Zwany Metting, Johanna M Fock, Joukje van der Naalt
BACKGROUND: Annually 14.000 children with traumatic brain injury (TBI) are admitted to the Emergency Department (ED) in the Netherlands. Presentation varies and a specific entity comprises the juvenile head trauma syndrome (JHTS) with secondary deterioration after a mild trauma. As outcome of JHTS can be fatal, early recognition is essential. AIM: To outline the epidemiology and clinical features of JHTS, in comparison to paediatric mild TBI patients without JHTS...
March 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/27679444/development-of-mechanical-and-failure-properties-in-sheep-cerebral-arteries
#15
Kevin S Nye, Matthew I Converse, Mar Janna Dahl, Kurt H Albertine, Kenneth L Monson
Traumatic brain injury (TBI) is a devastating problem for people of all ages, but the nature of the response to such injury is often different in children than in adults. Cerebral vessel damage and dysfunction are common following TBI, but age-dependent, large-deformation vessel response has not been characterized. Our objective was to investigate the mechanical properties of cerebral arteries as a function of development. Sheep middle cerebral arteries from four age groups (fetal, newborn, juvenile, and adult) were subjected to biaxial loading around physiological conditions and then to failure in the axial direction...
April 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27604726/pediatric-rodent-models-of-traumatic-brain-injury
#16
Bridgette D Semple, Jaclyn Carlson, Linda J Noble-Haeusslein
Due to a high incidence of traumatic brain injury (TBI) in children and adolescents, age-specific studies are necessary to fully understand the long-term consequences of injuries to the immature brain. Preclinical and translational research can help elucidate the vulnerabilities of the developing brain to insult, and provide model systems to formulate and evaluate potential treatments aimed at minimizing the adverse effects of TBI. Several experimental TBI models have therefore been scaled down from adult rodents for use in juvenile animals...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27484194/prevalence-and-assessment-of-traumatic-brain-injury-in-prison-inmates-a-systematic-prisma-review
#17
C S Allely
OBJECTIVES: The primary objectives of the present systematic PRISMA review were: (1) to explore the range of prevalence of TBI in offenders and whether this is higher than in a control sample; (2) to determine which screening measures are available and evaluate the evidence on these; and, lastly, (3) to evaluate whether prevalence of TBI is associated with increased prevalence of other health conditions and/or offending behaviour. METHODS: The present systematic PRISMA review explores the peer-reviewed literature published since 2005 which has investigated TBI in incarcerated populations using five databases (CINAHL, MEDLINE, PsycARTICLES, Psychology and Behavioral Sciences Collection, PsycINFO) in addition to separate searches conducted on 'Google Scholar' using specific search criteria...
2016: Brain Injury: [BI]
https://www.readbyqxmd.com/read/27335539/clinical-trial-perspective-for-adult-and-juvenile-huntington-s-disease-using-genetically-engineered-mesenchymal-stem-cells
#18
REVIEW
Peter Deng, Audrey Torrest, Kari Pollock, Heather Dahlenburg, Geralyn Annett, Jan A Nolta, Kyle D Fink
Progress to date from our group and others indicate that using genetically-engineered mesenchymal stem cells (MSC) to secrete brain-derived neurotrophic factor (BDNF) supports our plan to submit an Investigational New Drug application to the Food and Drug Administration for the future planned Phase 1 safety and tolerability trial of MSC/BDNF in patients with Huntington's disease (HD). There are also potential applications of this approach beyond HD. Our biological delivery system for BDNF sets the precedent for adult stem cell therapy in the brain and could potentially be modified for other neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS), spinocerebellar ataxia (SCA), Alzheimer's disease, and some forms of Parkinson's disease...
May 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27278858/probenecid-an-organic-anion-transporter-1-and-3-inhibitor-increases-plasma-and-brain-exposure-of-n-acetylcysteine
#19
Fanuel T Hagos, Monica J Daood, Jacob A Ocque, Thomas D Nolin, Hulya Bayir, Samuel M Poloyac, Patrick M Kochanek, Robert S B Clark, Philip E Empey
1. N-acetylcysteine (NAC) is being investigated as an antioxidant for several conditions including traumatic brain injury, but the mechanism by which it crosses membrane barriers is unknown. We have attempted to understand how the transporter inhibitor, probenecid, affects NAC pharmacokinetics and to evaluate the interaction of NAC with transporters. 2. Juvenile Sprague-Dawley rats were administered NAC alone or in combination with probenecid intraperitoneally. Plasma and brain samples were collected serially and NAC concentrations were measured...
April 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/26963289/prevalence-of-traumatic-brain-injury-and-epilepsy-among-prisoners-in-france-results-of-the-fleury-tbi-study
#20
E Durand, L Watier, M Fix, J J Weiss, M Chevignard, P Pradat-Diehl
OBJECTIVE: The first aim of this study was to estimate the prevalence of TBI and epilepsy in a French prison population and to study variables known to be associated with TBI. The second aim was to compare prisoners with and without a history of TBI. PARTICIPANTS: All offenders (females, males and juveniles) admitted consecutively to Fleury-Mérogis prison over a period of 3 months were included in the study. DESIGN: During the admission procedure, offenders were interviewed by healthcare staff using a self-reported questionnaire...
March 10, 2016: Brain Injury: [BI]
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