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https://www.readbyqxmd.com/read/29227587/corticosteroid-faceoff-which-is-best-for-treating-asthma-and-copd-exacerbations
#1
William Heuser, Richard Menaik, Sanjey Gupta, Robert Rucco
No abstract text is available yet for this article.
May 2017: JEMS: a Journal of Emergency Medical Services
https://www.readbyqxmd.com/read/29227362/comorbidity-of-airway-inflammatory-diseases-in-chemical-and-building-related-intolerance
#2
Anna-Sara Claeson, Hanna Andersson, Fredrik Wikdahl, Maj-Helen Nyback, Steven Nordin
OBJECTIVES: This study investigated comorbidity in chemical intolerance (CI) and building- related intolerance (BRI) with (i) chronic sinusitis, chronic obstructive pulmonary disease, allergic and non-allergic asthma and allergic rhinitis, and (ii) airway inflammatory symptoms. METHODS: Data from two population-based questionnaire surveys, the Västerbotten and Österbotten Environmental Health Studies was used. The participants were categorized as CI or BRI and referents, and binary logistic regression analysis was applied...
December 8, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29227024/blood-biomarkers-as-predictors-of-long-term-mortality-in-copd
#3
Angelico Mendy, Erick Forno, Theophile Niyonsenga, Janvier Gasana
BACKGROUND: Blood biomarkers are easily accessible and might reflect chronic obstructive pulmonary disease (COPD) activity. AIM: To determine whether a panel of blood biomarkers (C-reactive protein [CRP], neutrophils, eosinophils, albumin and vitamin D) could predict mortality in COPD. METHODS: we analyzed data from 431 COPD participants to the 2007-2010 National Health and Nutrition Examination Surveys who were followed for a median time of 36 months...
December 11, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29223018/targeting-oxidant-dependent-mechanisms-for-the-treatment-of-respiratory-diseases-and-their-comorbidities
#4
REVIEW
Neil C Thomson
Oxidative stress is implicated in the pathogenesis of respiratory diseases, such as COPD and its comorbidities, asthma, idiopathic pulmonary fibrosis and radiation pneumonitis. Antioxidants drugs, such as small molecule thiols, nuclear erythroid-2 related factor 2 activators and catalytic enzyme mimetics have been developed to target oxidant-dependent mechanisms. The therapeutic effects of antioxidants have been generally disappointing. A small number of antioxidants are approved for clinical use, such as the small molecule thiol N-acetyl-l-cysteine for chronic obstructive pulmonary disease, and in the United States, the superoxide dismutase mimetic AEOL 10150 for severe radiation pneumonitis...
December 6, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29221325/foreign-body-aspiration-in-adult-airways-therapeutic-approach
#5
REVIEW
Justin C Hewlett, Otis B Rickman, Robert J Lentz, Udaya B Prakash, Fabien Maldonado
Tracheobronchial foreign body (FB) aspiration is an uncommon but potentially life-threatening event in adults. Symptoms typically consist of a choking event followed by cough and dyspnea, however, these findings are inconsistent and symptoms may mimic more chronic lung diseases such as asthma or chronic obstructive pulmonary disease. Chest radiography and computed tomography can provide information regarding the location and characteristics of foreign bodies and aid in diagnosis. Bronchoscopy remains the gold standard for diagnosis and management of FB aspiration...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29220595/dose-dependent-effects-of-tadalafil-and-roflumilast-on-ovalbumin-induced-airway-hyperresponsiveness-in-guinea-pigs
#6
Anna Urbanova, Ivana Medvedova, Martin Kertys, Pavol Mikolka, Petra Kosutova, Daniela Mokra, Juraj Mokrý
INTRODUCTION: Chronic obstructive diseases of airways associated with cough and/or airway smooth muscle hyperresponsiveness are usually treated with bronchodilating and anti-inflammatory drugs. Recently, selective phosphodiesterase (PDE) 4 inhibitors have been introduced into the therapy of chronic obstructive pulmonary disease. Several studies have demonstrated their ability to influence the airway reactivity and eosinophilic inflammation by increasing the intracellular cAMP concentrations also in bronchial asthma...
December 8, 2017: Experimental Lung Research
https://www.readbyqxmd.com/read/29217598/phenotypes-of-symptomatic-airways-disease-in-china-and-new-zealand
#7
James Fingleton, Kewu Huang, Mark Weatherall, Yanfei Guo, Stefan Ivanov, Piet Bruijnzeel, Hong Zhang, Wei Wang, Richard Beasley, Chen Wang
It is uncertain whether phenotypes of asthma and chronic obstructive pulmonary disease (COPD) vary between populations with different genetic and environmental characteristics. Here, our objective was to compare the phenotypes of airways disease in two separate populations.This was a cross-sectional observational study in adult populations from New Zealand and China. Participants aged 40-75 years who reported wheeze and breathlessness in the last 12 months were randomly selected from the general population and underwent detailed characterisation...
December 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29216852/access-to-affordable-medicines-and-diagnostic-tests-for-asthma-and-copd-in-sub-saharan-africa-the-ugandan-perspective
#8
Davis Kibirige, Leaticia Kampiire, David Atuhe, Raymond Mwebaze, Winceslaus Katagira, Winters Muttamba, Rebecca Nantanda, William Worodria, Bruce Kirenga
BACKGROUND: Equitable access to affordable medicines and diagnostic tests is an integral component of optimal clinical care of patients with asthma and chronic obstructive pulmonary disease (COPD). In Uganda, we lack contemporary data about the availability, cost and affordability of medicines and diagnostic tests essential in asthma and COPD management. METHODS: Data on the availability, cost and affordability of 17 medicines and 2 diagnostic tests essential in asthma and COPD management were collected from 22 public hospitals, 23 private and 85 private pharmacies...
December 8, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29216193/community-prevalence-of-chronic-respiratory-symptoms-in-rural-malawi-implications-for-policy
#9
Hastings T Banda, Rachael Thomson, Kevin Mortimer, George A F Bello, Grace B Mbera, Rasmus Malmborg, Brian Faragher, S Bertel Squire
BACKGROUND: No community prevalence studies have been done on chronic respiratory symptoms of cough, wheezing and shortness of breath in adult rural populations in Malawi. Case detection rates of tuberculosis (TB) and chronic airways disease are low in resource-poor primary health care facilities. OBJECTIVE: To understand the prevalence of chronic respiratory symptoms and recorded diagnoses of TB in rural Malawian adults in order to improve case detection and management of these diseases...
2017: PloS One
https://www.readbyqxmd.com/read/29215657/-the-patient-and-the-crossing-between-primary-and-hospital-care-systematic-review-of-trials-for-the-implementation-of-tools-for-integration-in-spain
#10
REVIEW
L Corral Gudino, M Borao Cengotita-Bengoa, R J Jorge Sánchez, J García Aparicio
BACKGROUND: Health services are moving towards a complete integration to try and reduce fragmentation, increase efficiencies and improve health outcomes. Estimates the effectiveness in of different tools for integrated care in Spain. METHODS: We performed a systematic review of articles using MEDLINE (last search July31st, 2017). Randomized clinical trials reporting health outcomes of tools for integrated care used in Spain were included. Studies were appraised for quality using the Cochrane Risk of Bias assessment...
December 7, 2017: Anales del Sistema Sanitario de Navarra
https://www.readbyqxmd.com/read/29212488/identification-of-the-lipid-biomarkers-from-plasma-in-idiopathic-pulmonary-fibrosis-by-lipidomics
#11
Feng Yan, Zhensong Wen, Rui Wang, Wenling Luo, Yufeng Du, Wenjun Wang, Xianyang Chen
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is an irreversible interstitial pulmonary disease featured by high mortality, chronic and progressive course, and poor prognosis with unclear etiology. Currently, more studies have been focusing on identifying biomarkers to predict the progression of IPF, such as genes, proteins, and lipids. Lipids comprise diverse classes of molecules and play a critical role in cellular energy storage, structure, and signaling. The role of lipids in respiratory diseases, including cystic fibrosis, asthma and chronic obstructive pulmonary disease (COPD) has been investigated intensely in the recent years...
December 6, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29207992/correction-to-chronic-obstructive-pulmonary-disease-bronchial-asthma-and-allergic-rhinitis-in-the-adult-population-within-the-commonwealth-of-independent-states-rationale-and-design-of-the-core-study
#12
Yuriy Feshchenko, Liudmyla Iashyna, Damilya Nugmanova, Olga Gyrina, Maryna Polianska, Alexander Markov, Maryna Moibenko, Janina Makarova, Luqman Tariq, Marcelo Horacio S Pereira, Eljan Mammadbayov, Irada Akhundova, Averyan Vasylyev
After publication of this work [1] it was noticed three author names were spelt incorrectly. Liudmila Iashyna should be Liudmyla Iashyna, Marina Polyanskaya should be Maryna Polianska and Elcan Mamamdbayov should be Eljan Mammadbayov.
December 5, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29207030/der-f1-induces-pyroptosis-in-human-bronchial-epithelia-via-the-nlrp3-inflammasome
#13
Ying-Ming Tsai, Kuo-Hwa Chiang, Jen-Yu Hung, Wei-An Chang, Hui-Ping Lin, Jiunn-Min Shieh, Inn-Wen Chong, Ya-Ling Hsu
Damage to the bronchial epithelium leads to persistent inflammation and airway remodelling in various respiratory diseases, such as asthma and chronic obstructive pulmonary disease. To date, the mechanisms underlying bronchial epithelial cell damage and death by common allergens remain largely unknown. The aim of the present study was to investigate Der f1, an allergen of Dermatophagoides farinae, which may result in the death of human bronchial epithelial cells (HBECs). Der f1 induces BECs to undergo the inflammatory cell death referred to as pyroptosis, induced by increasing lactate dehydrogenase release and propidium iodide penetration...
December 5, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29202939/risk-factors-for-herpes-zoster-a-systematic-review-and-meta-analysis
#14
Kosuke Kawai, Barbara P Yawn
OBJECTIVE: To systematically review studies examining risk factors for herpes zoster (HZ). METHODS: We performed a literature search using PubMed, EMBASE, and Web of Science for articles published from January 1, 2003, to February 1, 2017. A random-effects model was used to summarize the risk ratio (RR) or odds ratio (OR) and 95% CI. RESULTS: Of the 3450 studies screened, we included 84 studies in the systematic review and conducted meta-analysis in 62 studies...
December 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29201082/pharmacophore-based-virtual-screening-approach-to-identify-selective-pde4b-inhibitors
#15
Anand Gaurav, Vertika Gautam
Phosphodiesterase 4 (PDE4) has been established as a promising target in asthma and chronic obstructive pulmonary disease. PDE4B subtype selective inhibitors are known to reduce the dose limiting adverse effect associated with non-selective PDE4B inhibitors. This makes the development of PDE4B subtype selective inhibitors a desirable research goal. To achieve this goal, ligand based pharmacophore modeling approach is employed. Separate pharmacophore hypotheses for PDE4B and PDE4D inhibitors were generated using HypoGen algorithm and 106 PDE4 inhibitors from literature having thiopyrano [3,2-d] Pyrimidines, 2-arylpyrimidines, and triazines skeleton...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29199167/which-diseases-are-risk-factors-for-developing-gastroesophageal-reflux-disease
#16
Filiz Akyüz, Özlem Mutluay Soyer
Although the pathophysiology of gastroesophageal reflux disease (GERD) remains unclear, it is accepted as a multifactorial disease. It is thought that some of the interventions that might cause alterations in the normal gastrointestinal tract anatomy and diseases that affect the lower esophageal sphincter, esophageal clearance, and stomach motility (gastric emptying) might lay a foundation for GERD development. Moreover, it is common knowledge that GERD might cause various extraesophageal symptoms and complications...
December 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29197631/pulmonary-drug-delivery-to-older-people
#17
Martin Wallin, Tatsuaki Tagami, Lan Chen, Mingshi Yang, Hak-Kim Chan
Pulmonary diseases, such as asthma and chronic obstructive pulmonary disease (COPD), are common in older people. Treatment principles are well established in this group of patients; however, inadequate training and improper inhaler techniques often results in poor treatment outcomes. Healthcare professionals often do not have the required knowledge about the most common inhaler devices. Age-related conditions like cognitive ability and physical strength would also impact on the inhaler usage. Pharmacokinetics and pharmacodynamics may be affected by physiological changes, like impaired renal and hepatic functions and reduced lung functions...
November 29, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29193245/review-article-gastro-oesophageal-reflux-disease-in-asthma-and-chronic-obstructive-pulmonary-disease
#18
REVIEW
C Broers, J Tack, A Pauwels
BACKGROUND: When gastro-oesophageal reflux is causing symptoms or lesions in the oesophagus, this is referred to as gastro-oesophageal reflux disease (GERD). GERD can manifest itself through typical symptoms (heartburn, regurgitation) or may lead to extra-oesophageal symptoms. Extra-oesophageal manifestations of GERD gained increasing attention over the last decade, especially respiratory disorders, because of the prevalent co-occurrence with GERD. The role of GERD in the pathogenesis of respiratory disorders has become a topic of intense discussion...
November 29, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29187913/an-online-monitor-of-the-oxidative-capacity-of-aerosols-o-moca
#19
Arantzazu Eiguren-Fernandez, Nathan Kreisberg, Susanne Hering
The capacity of airborne particulate matter to generate reactive oxygen species (ROS) has been correlated with the generation of oxidative stress both in vitro and in vivo. The cellular damage from oxidative stress, and by implication with ROS, is associated with several common diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and some neurological diseases. Yet currently available chemical and in vitro assays to determine the oxidative capacity of ambient particles require large samples, analyses are typically done offline, and the results are not immediate...
2017: Atmospheric Measurement Techniques
https://www.readbyqxmd.com/read/29183838/abediterol-las100977-an-inhaled-long-acting-%C3%AE-2-adrenoceptor-agonist-has-a-fast-association-rate-and-long-residence-time-at-receptor
#20
Israel Ramos, Mònica Aparici, Maria Letosa, Carlos Puig, Amadeu Gavaldà, Josep Maria Huerta, Sonia Espinosa, Dolors Vilella, Montserrat Miralpeix
This study describes the association rate and residence time of abediterol, a novel long-acting β2-adrenoceptor agonist (LABA) in Phase II development for treatment of asthma and COPD, in comparison with indacaterol, olodaterol, vilanterol and salmeterol, for both human β1- and β2-adrenoceptors. Abediterol association and dissociation rates were monitored directly by using its tritiated form. Moreover, association was determined indirectly using experimental Ki and koff obtained from assays performed with unlabelled compound...
November 25, 2017: European Journal of Pharmacology
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