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klebsiella pneumonia

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https://www.readbyqxmd.com/read/28918351/susceptibility-profiles-of-bacteria-causing-urinary-tract-infection-in-southern-tunisia
#1
Sonda Guermazi-Toumi, Sirine Boujlel, Mouna Assoudi, Riadh Issaoui, Sonia Tlili, Mohamed Ennaceur Hlaiem
OBJECTIVES: The aim of this study was to determine the epidemiological profile and the antibiotic resistance of bacteria responsible for urinary infections diagnosed in the department of microbiology of the regional hospital Houcine Bouzaiene (Gafsa) in the south west of Tunisia. METHODS: All the cytobacteriological urine samples analyzed from 1 January 2015 to 30 June 2016 were included in the study. The adopted criteria to define urinary infection were: leukocyturia >10(4)/ml and bacteriuria >10(5)CFU/ml...
September 13, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28915364/nosocomial-multidrug-resistant-klebsiella-pneumoniae-strains-isolated-from-mexico-city-produce-robust-biofilms-on-abiotic-surfaces-but-not-on-human-lung-cells
#2
Martha Lorena Ostria-Hernandez, Karla Cecilia Juárez-de la Rosa, Patricia Arzate-Barbosa, Antonino Lara-Hernández, Fuminori Sakai, J Antonio Ibarra, Graciela Castro-Escarpulli, Jorge E Vidal
BACKGROUND: Klebsiella pneumoniae (Kpn) strains are a leading cause of hospital-acquired infections, including ventilator-associated pneumonia. Resistance to antibiotics, biofilm formation, and the production of certain fimbriae play an important role in the pathogenesis. AIM: We investigated the genetic relatedness, antibiotic resistance, virulence potential, and ability to form biofilms of Kpn strains isolated from hospital-acquired infections (n = 76). Strains were isolated at three major hospitals serving the largest metropolitan urban area in Mexico City, Mexico...
September 15, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28914748/klebsiella-pneumoniae-virulence-biofilm-and-antimicrobial-resistance
#3
Evangelia-Theophano Piperaki, George A Syrogiannopoulos, Leonidas S Tzouvelekis, George L Daikos
No abstract text is available yet for this article.
October 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28913784/managing-wastes-as-green-resources-cigarette-butt-synthesized-pesticides-are-highly-toxic-to-malaria-vectors-with-little-impact-on-predatory-copepods
#4
Kadarkarai Murugan, Udaiyan Suresh, Chellasamy Panneerselvam, Rajapandian Rajaganesh, Mathath Roni, Al Thabiani Aziz, Jiang-Shiou Hwang, Kuppusamy Sathishkumar, Aruliah Rajasekar, Suresh Kumar, Abdullah A Alarfaj, Akon Higuchi, Giovanni Benelli
The development of novel mosquito control tools is a key prerequisite to build effective and reliable Integrated Vector Management strategies. Here, we proposed a novel method using cigarette butts for the synthesis of Ag nanostructures toxic to young instars of the malaria vector Anopheles stephensi, chloroquine (CQ)-resistant malaria parasites Plasmodium falciparum and microbial pathogens. The non-target impact of these nanomaterials in the aquatic environment was evaluated testing them at sub-lethal doses on the predatory copepod Mesocyclops aspericornis...
September 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28912335/draft-genome-sequence-of-klebsiella-pneumoniae-ok8-a-multidrug-resistant-mouse-and-human-pathogen
#5
Easa Nagamalleswari, Valakunja Nagaraja
We report here the draft genome sequence of Klebsiella pneumoniae OK8, a multidrug-resistant strain which was isolated in 1976 from a human and is known to be a mouse pathogen.
September 14, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28912306/complete-nucleotide-sequence-of-klebsiella-pneumoniae-bacteriophage-vb_kpnm_kpv477
#6
Ekaterina V Komisarova, Angelina A Kislichkina, Valentina M Krasilnikova, Alexander G Bogun, Nadezhda K Fursova, Nikolay V Volozhantsev
The double-stranded DNA (dsDNA) bacteriophage vB_KpnM_KpV477, with a broad spectrum of lytic activity against Klebsiella pneumoniae, including strains of capsular serotypes K1, K2, and K57, was isolated from a clinical sample. The phage genome comprises 168,272 bp, with a G+C content of 39.3%, and it contains 275 putative coding sequences (CDSs) and 17 tRNAs.
September 14, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28910379/a-one-year-prospective-study-of-colonization-with-antimicrobial-resistant-organisms-on-admission-to-a-vietnamese-intensive-care-unit
#7
Duong Bich Thuy, James Campbell, Nguyen Van Minh Hoang, Truong Thi Thuy Trinh, Ha Thi Hai Duong, Nguyen Chi Hieu, Nguyen Hoang Anh Duy, Nguyen Van Hao, Stephen Baker, Guy E Thwaites, Nguyen Van Vinh Chau, C Louise Thwaites
There is a paucity of data regarding initial bacterial colonization on admission to Intensive Care Units (ICUs) in low and middle-income countries (LMICs). Patients admitted to ICUs in LMICs are at high-risk of subsequent infection with antimicrobial-resistant organisms (AROs). We conducted a prospective, observational study at the Hospital for Tropical Diseases in Ho Chi Minh City, Vietnam from November 2014 to January 2016 to assess the colonization and antimicrobial susceptibility of Staphylococcus aureus, Escherichia coli, Klebsiella spp...
2017: PloS One
https://www.readbyqxmd.com/read/28906397/clinical-and-microbiological-characteristics-of-pyogenic-liver-abscess-in-a-tertiary-hospital-in-east-china
#8
Haishen Kong, Fei Yu, Weili Zhang, Xuefen Li
Pyogenic liver abscess (PLA) is a potentially life-threatening disease affecting many parts of the world, especially Asia. In this study, we explored the clinical and microbiological characteristics of PLA in Chinese patients.A 5-year (2010-2014) retrospective review of medical records on all PLA patients who were admitted to a tertiary teaching hospital was performed.Among 217 PLA cases who were confirmed cultural positive, Klebsiella pneumonia (K pneumonia) was the most common pathogen (n = 165, 76.0%), followed by Escherichia coli (n = 21, 9...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28901763/bioassay-guided-isolation-of-antibacterial-metabolites-from-emericella-sp-tj29
#9
Yan He, Zhengxi Hu, Qin Li, Jinfeng Huang, Xiao-Nian Li, Hucheng Zhu, Junjun Liu, Jianping Wang, Yongbo Xue, Yonghui Zhang
Bioassay-guided isolation of metabolites from cultures of the plant-derived fungus Emericella sp. TJ29 yielded three new terpene-polyketide hybrid meroterpenoids, emervaridones A-C (1-3), two new polyketides, varioxiranediols A and B (5 and 6), and three known analogues (4, 7, and 8). The structures and absolute configurations of these new compounds were elucidated by spectroscopic analyses, single-crystal X-ray diffraction, Mo2(OAc)4-induced electronic circular dichroism (ECD) data, and ECD calculations. To date, only one compound (4) bearing the emervaridone-type carbocyclic skeleton has been reported...
September 13, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28899468/-pathogen-distribution-and-bacterial-resistance-in-children-with-severe-community-acquired-pneumonia
#10
Yun-Yun Lu, Rong Luo, Zhou Fu
OBJECTIVE: To investigate the distribution of pathogens and bacterial resistance in children with severe community-acquired pneumonia (CAP). METHODS: A total of 522 children with severe CAP who were hospitalized in 2016 were enrolled as study subjects. According to their age, they were divided into infant group (402 infants aged 28 days to 1 year), young children group (73 children aged 1 to 3 years), preschool children group (35 children aged 3 to 6 years), and school-aged children group (12 children aged ≥6 years)...
September 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28899399/a-comparison-of-blood-stream-infections-with-extended-spectrum-beta-lactamase-producing-and-non-producing-klebsiella-pneumoniae-in-pediatric-patients
#11
Sevgen Tanır Basaranoglu, Yasemin Ozsurekci, Kubra Aykac, Eda Karadag Oncel, Asiye Bıcakcigil, Banu Sancak, Ali Bulent Cengiz, Ates Kara, Mehmet Ceyhan
BACKGROUND: Rapid development and global spread of multidrug resistant Klebsiella pneumonia (K. pneumoniae) as a major cause of nosocomial infections is really remarkable. The aim of this study was to explore risk factors for health care associated blood stream infections (BSI) caused by ESBL-producing K. pneumoniae in children and analyze clinical outcomes. METHODS: A retrospective review of patients younger than 18 years-old with blood stream infection caused by K...
September 12, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28898859/antibacterial-clay-against-gram-negative-antibiotic-resistant-bacteria
#12
Luis Zarate-Reyes, Cynthia Lopez-Pacheco, Antonio Nieto-Camacho, Eduardo Palacios, Virginia Gómez-Vidales, Stephan Kaufhold, Kristian Ufer, Eduardo García Zepeda, Javiera Cervini-Silva
Antibiotic resistant bacteria persist throughout the world because they have evolved the ability to express various defense mechanisms to cope with antibiotics and the immune system; thus, low-cost strategies for the treatment of these bacteria are needed, such as the usage of environmental minerals. This paper reports the antimicrobial properties of a clay collected from Brunnenberg, Germany, that is composed of ferroan saponite with admixtures of quartz, feldspar and calcite as well as exposed or hidden (layered at inner regions) nano Fe(0)...
September 1, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28898618/-klebsiella-pneumoniae-from-k1-and-hypervirulent-clone-st23-first-documented-case-in-portugal
#13
Aida Pereira, Tiago Petrucci, Maria João Simões
The hypervirulent K1 serotype Klebsiella pneumoniae is responsible for a new invasive syndrome, typically associated to hepatic abscesses with extra-hepatic complications. Initially described in Taiwan, it has significantly spread to several Asian countries and more recently to Europe and North America, thus constituting an emerging and global problem. The authors describe a case report of a 64-years-old portuguese caucasian woman without any previous diseases or epidemiological risk factors such as trips or contact with Asian products or population, diagnosed with a pyogenic liver abscess with pleural effusion caused by this hyper-virulent strain...
June 30, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28898269/faecal-carriage-of-ctx-m-extended-spectrum-beta-lactamase-producing-enterobacteriaceae-among-street-children-dwelling-in-mwanza-city-tanzania
#14
Nyambura Moremi, Heike Claus, Ulrich Vogel, Stephen E Mshana
BACKGROUND: Data on ESBL carriage of healthy people including children are scarce especially in developing countries. We analyzed the prevalence and genotypes of ESBL-producing Enterobacteriaceae (EPE) in Tanzanian street children with rare contact to healthcare facilities but significant interactions with the environment, animals and other people. METHODOLOGY/ PRINCIPLE FINDINGS: Between April and July 2015, stool samples of 107 street children, who live in urban Mwanza were analyzed for EPE...
2017: PloS One
https://www.readbyqxmd.com/read/28895046/characterization-of-cadmium-resistant-klebsiella-pneumoniae-mcc-3091-promoted-rice-seedling-growth-by-alleviating-phytotoxicity-of-cadmium
#15
Krishnendu Pramanik, Soumik Mitra, Anumita Sarkar, Tithi Soren, Tushar Kanti Maiti
Cadmium (Cd) phytotoxicity in agricultural land is a major global concern now-a-days resulting in very poor yield. Plant growth-promoting rhizobacteria (PGPR)-mediated bioremediation is one of the convenient strategies for detoxification of Cd from the soil and for plant growth promotion under Cd stress. The selected strain K5 was identified as Klebsiella pneumoniae based on MALDI-TOF MS ribosomal protein and 16S rDNA sequence-based homology. The strain possessed several PGP traits viz. IAA production (3413 μg/mL), phosphate solubilization (80...
September 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28894448/sirtuin-2-deficiency-increases-bacterial-phagocytosis-by-macrophages-and-protects-from-chronic-staphylococcal-infection
#16
Eleonora Ciarlo, Tytti Heinonen, Charlotte Théroude, Jacobus Herderschee, Matteo Mombelli, Jérôme Lugrin, Marc Pfefferlé, Beatrice Tyrrell, Sarah Lensch, Hans Acha-Orbea, Didier Le Roy, Johan Auwerx, Thierry Roger
Sirtuin 2 (SIRT2) is one of the seven members of the family of NAD(+)-dependent histone deacetylases. Sirtuins target histones and non-histone proteins according to their subcellular localization, influencing various biological processes. SIRT2 resides mainly in the cytoplasm and regulates cytoskeleton dynamics, cell cycle, and metabolic pathways. As such, SIRT2 has been implicated in the pathogenesis of neurodegenerative, metabolic, oncologic, and chronic inflammatory disorders. This motivated the development of SIRT2-directed therapies for clinical purposes...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28893788/genomic-and-molecular-characterization-of-clinical-isolates-of-enterobacteriaceae-harboring-mcr-1-in-colombia-2002-2016
#17
Sandra Yamile Saavedra, Lorena Diaz, Magdalena Wiesner, Adriana Correa, Stefany Alejandra Arévalo, Jinnethe Reyes, Andrea Melissa Hidalgo, Elsa de la Cadena, Marcela Perenguez, Lucy Angeline Montaño, Javier Ardila, Rafael Ríos, María Victoria Ovalle, Paula Díaz, Paola Porras, Maria V Villegas, Cesar A Arias, Mauricio Beltrán, Carolina Duarte
Polymyxins are last resort antimicrobial agents used to treat infections caused by carbapenem-resistant Enterobacteriaceae Due to the worldwide dissemination of polymyxin resistance in animal and human isolates, we aimed to characterize polymyxin resistance associated with the presence of mcr-1 in Enterobacteriaceae and nonfermenter Gram-negative bacilli, in isolates collected retrospectively in Colombia from 2002 to 2016. A total of 5,887 Gram-negative clinical isolates were studied and 513 were found to be resistant to the polymyxins...
September 11, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28893689/management-of-kpc-producing-klebsiella-pneumoniae-infections
#18
REVIEW
M Bassetti, D R Giacobbe, H Giamarellou, C Viscoli, G L Daikos, G Dimopoulos, F G De Rosa, E J Giamarellos-Bourboulis, G M Rossolini, E Righi, I Karaiskos, M Tumbarello, D P Nicolau, P L Viale, G Poulakou
BACKGROUND: Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) has become one of the most important contemporary pathogens, especially in endemic areas. AIMS: our aim was to provide practical suggestion for physicians dealing with the management of KPC-KP infections in critically ill patients, based on expert opinions. SOURCES: PubMed search for relevant publications related to the management of KPC-KP infections. CONTENTS: a panel of experts developed a list of 12 questions to be addressed...
September 9, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28893646/whole-genome-sequence-of-a-carbapenem-resistant-hypermucoviscous-klebsiella-pneumoniae-isolate-swu01-with-capsular-serotype-k47-that-belongs-to-st11-from-a-patient-in-china
#19
Luhua Zhang, Ying Li, Wei Shen, Guangxi Wang, Yingshun Zhou
OBJECTIVES: In recent years, Klebsiella pneumoniae is emerging as a leading cause of nosocomial infection due to the rapid prevalence of multidrug resistant strains, particularly the carbapenem resistant isolates. In this study, we completed the genome sequence of a carbapenem-resistant K. pneumoniae SWU01. METHODS: Antimicrobial susceptibilities and hypermucoviscous phenotype were determined by the disk diffusion method and a positive string test, respectively...
September 8, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28893358/discrepant-susceptibility-to-gentamicin-despite-amikacin-resistance-in-klebsiella-pneumoniae-by-vitek-2-represents-false-susceptibility-associated-with-the-arma-16s-rrna-methylase-gene
#20
Jae-Hoon Ko, Jin Yang Baek, Kyong Ran Peck, Sun Young Cho, Young Eun Ha, So Hyun Kim, Hee Jae Huh, Nam Yong Lee, Cheol-In Kang, Doo Ryeon Chung, Jae-Hoon Song
Because we experienced gentamicin failure in Klebsiella pneumoniae bacteraemia that was susceptible to gentamicin despite amikacin resistance, as determined by VITEK 2, we evaluated the true susceptibility and mechanism of resistance. We screened 2818 K. pneumoniae isolates during a 1-year period at a university hospital and reviewed anti-microbial susceptibility reports using the VITEK 2 system. The minimum inhibitory concentration was substantiated by broth microdilution (BMD), and the presence of 16S rRNA methylase genes and aminoglycoside-modifying enzymes was also investigated...
September 12, 2017: Journal of Medical Microbiology
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