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Alan J Wein
No abstract text is available yet for this article.
November 2016: Journal of Urology
Ching-Chung Liang, Tsong-Hai Lee, Shuenn-Dhy Chang
OBJECTIVE: To demonstrate the effect of human umbilical cord blood-derived CD34(+) cells on bladder dysfunction induced by cerebral ischemia in rats. MATERIALS AND METHODS: Female rats were subjected to either 60 minute middle cerebral artery occlusion (MCAO) or a sham operation. Rats were divided into four groups: sham operation, MCAO without treatment, infusion with 1×10(6) CD34(+) cells 30 minutes before MCAO, and infusion with 1×10(6) CD34(+) cells 3 hours after MCAO...
October 2016: Taiwanese Journal of Obstetrics & Gynecology
Sang Wook Lee, Woong Bin Kim, Kwang Woo Lee, Jun Mo Kim, Young Ho Kim, Bora Lee, Jae Heon Kim
OBJECTIVE: We compared the therapeutic efficacy of transurethral resection (TUR) alone to that of TUR combined with therapeutic hydrodistention in patients with ulcerative interstitial cystitis (IC). METHODS: The study subjects were newly diagnosed IC patients 44 female patients who underwent TUR to treat ulcerative IC and who were available for follow-up, without recurrence of disease for 12 months. We retrospectively studied both patients who underwent TUR alone (Group I) and those who underwent TUR combined with therapeutic hydrodistention (Group II)...
October 5, 2016: Urology
V I Kirpatovskii, I S Mudraya, S V Revenko, A Yu Bablumyan, N K Adamyan, V P Ivanov
The therapeutic effect of doxazosin (40 μg/kg/day over one month) on urinary bladder was examined in female rats with modeled chronic infravesical obstruction (IVO) produced by graduated mechanical constriction of the proximal urethral segment. In one month, IVO induced a pronounced vesical hypertrophy both in treated and untreated rats that manifested in increased bladder weight and capacity, the latter increment being pronouncedly greater in treated rats. In untreated IVO rats, infusion cystometry revealed elevated basal intravesical pressure of void bladder P0, markedly increased maximal (premicturitional) pressure Pmax, and increased amplitude of spontaneous oscillations of intravesical pressure ΔPdet in filled bladder...
September 2016: Bulletin of Experimental Biology and Medicine
Ana L Lopes Mendes, Veerle Decalf, Marie A Denys, Andrea Tubaro, Karel Everaert
BACKGROUND: Bladder dysfunctions often express the presence of lower urinary tract symptoms (LUTS) and are common in older people. Aim of this study is to analyse the Micturition, Incontinence and Residual in older people, evaluating the role of Nocturnal Polyuria. METHODS: 86 patients with at least 65 years old and invalidating LUTS were hospitalized for 24 hours. The Maximum Bladder Capacity, mean Micturition Volume, Post Voiding Residual and Incontinence Volume were recorded and analysed day-time and night-time...
October 5, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
Wei-Chia Lee, You-Lin Tain, Kay L H Wu, Steve Leu, Julie Y H Chan
Maternal fructose exposure (MFE) programs the development of metabolic syndrome (MetS) in young adult offspring. Epidemiological data indicate that MetS may increase the risks of overactive bladder (OAB) symptoms. However, it remains unknown whether MFE programs MetS-associated bladder dysfunction in adult offspring. Using Sprague-Dawley rats, we investigated the effects of MFE during pregnancy and lactation on developmental programming of MetS-associated bladder dysfunction. In addition, next generation sequencing technology was used to identify potential transcripts involved in the programmed bladder dysfunction in adult male offspring to MFE...
October 5, 2016: Scientific Reports
Pawel Miotla, Rufus Cartwright, Katarzyna Skorupska, Michal Bogusiewicz, Ewa Markut-Miotla, Konrad Futyma, Tomasz Rechberger
AIMS: Urgency urinary incontinence (UUI), and the symptoms of overactive bladder (OAB) have a negative impact on female sexual function. The aim of this study was to investigate the effect of intravesical onabotulinumtoxinA (Botox) injection on sexual function in women with OAB, using the multi domain Female Sexual Function Index (FSFI) questionnaire. METHODS: Sixty-eight sexually active women with idiopathic OAB with at least one episode of UUI and ≥8 micturitions per 24 h were recruited...
October 4, 2016: Neurourology and Urodynamics
Donald Newgreen, Brigitte Bosman, Adriana Hollestein-Havelaar, Ellen Dahler, Robin Besuyen, Will Sawyer, Stéphane Bolduc, Søren Rittig
BACKGROUND: Solifenacin, an effective, well-tolerated treatment for adult overactive bladder (OAB) symptoms, has not been evaluated in placebo-controlled paediatric clinical trials. OBJECTIVES: To evaluate the efficacy and safety of once-daily oral solifenacin suspension in OAB patients aged 5-<12 yr (children) and 12-<18 yr (adolescents). DESIGN, SETTING, AND PARTICIPANTS: The study involved a 4-wk urotherapy run-in followed by 1:1 randomisation to 12-wk double-blind solifenacin or placebo treatment alongside urotherapy...
September 26, 2016: European Urology
Atsushi Otsuka, Shinji Kageyama, Takahisa Suzuki, Rikiya Matsumoto, Hiroshi Nagae, Motoaki Kitagawa, Hiroshi Furuse, Seiichiro Ozono
OBJECTIVES: To evaluate the efficacy and safety of mirabegron compared with imidafenacin for the treatment of female patients with overactive bladder. METHODS: Patients (n = 89) were randomized to receive 0.1 mg imidafenacin twice daily (n = 47) or 50 mg mirabegron once daily (n = 42) for 12 weeks. The primary efficacy end-point was change in total Overactive Bladder Symptom Score. Secondary efficacy end-points included change in Overactive Bladder Symptom Score, 3-day micturition diary, International Prostate Symptom Score and Overactive Bladder Questionnaire...
September 29, 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
Suming Xu, Xu Wang, Yaoqin Wang, Susan Lutgendorf, Catherine Bradley, Andrew Schrepf, Karl Kreder, Michael O'Donnell, Yi Luo
Monocyte chemoattractant protein-1 (MCP-1) is one of the key chemokines that play important roles in diverse inflammatory and chronic pain conditions. Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic and debilitating inflammatory condition of the urinary bladder characterized by the hallmark symptoms of pelvic pain and voiding dysfunction. To facilitate IC/BPS research, we used transgenic technology to develop a novel urothelial MCP-1 secretion mouse model (URO-MCP-1). A transgene consisting of the uroplakin II gene promoter and the mouse MCP-1 coding sequence with a secretory element was constructed and microinjected...
2016: PloS One
Kenia López-García, Silvia Mariscal-Tovar, Martín Alejandro Serrano-Meneses, Francisco Castelán, Margarita Martínez-Gómez, Ismael Jiménez-Estrada
AIMS: We analyzed the effect of multiparity on the fiber type composition of two skeletal muscles involved in the maintenance of the micturition process, the pelvic pubococcygeus (Pc) and perineal bulbospongiosus (Bs) muscles in nulliparous and multiparous rabbits (Oryctolagus cuniculus). METHODS: We used the basic ATPase and NADH-TR techniques to identify and characterize slow, intermediate, and fast fiber types and glycolitic and oxidative fibers in muscles, respectively...
September 27, 2016: Neurourology and Urodynamics
Thibault Pasquet, Eva Chinier, Julien Durigneux, Amélie Anselmetti, Chantal Tessiot, Marion Beaumesnil, Matthieu Delion, Mickael Dinomais
OBJECTIVE: We present a case of voiding symptoms after an isolated hemorrhagic cerebellum stroke of the right cerebellum hemisphere and the vermis in a 15 year-old boy with no medical history. The aim of this case is to show existence of a link between cerebellum and micturition. OBSERVATIONS: Following the stroke, the patient described dysuria, confirmed by uroflowmetry, with significants post-voiding residuals. Cystometry showed no detrusor contraction and urethral profilometry showed an increase in sphincter tone...
September 2016: Annals of Physical and Rehabilitation Medicine
Laura Weglinski, Rebecca Haddad, Benoit Peyronnet, Xavier Game, Calin Ciofu, Gerard Amarenco
OBJECTIVE: Intradetrusorial injection of botulinum toxin A (IDBT) is a validated treatment for neurogenic and non-neurogenic refractory overactive bladder. In the elderly, muscarinic antagonists have many side effects, in particular in cognition. An alternative treatment is, for that reason, interesting in this frail population with multiple medication use. The question of efficacy is remaining. Indeed, bladder dysfunction is most of the time a multifactorial issue in the elderly. The objective of this study was to evaluate prospectively the efficacy and safety of IDBT in this population...
September 2016: Annals of Physical and Rehabilitation Medicine
Hans L Carlson, Nathaniel Baer
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
Rose Khavari, Christof Karmonik, Michael Shy, Sophie Fletcher, Timothy Boone
PURPOSE: Neurogenic Lower Urinary Tract Dysfunction (NLUTD) is common in multiple sclerosis (MS) patients with a significant impact on their quality of life. In this study, we seek to discover brain activity processes during the micturition cycle in female patients with MS and NLUTD. MATERIALS AND METHODS: We report brain activity via functional magnetic resonance imaging (fMRI) and simultaneous urodynamic testing (UDS) in twenty-three ambulatory female patients with MS...
September 21, 2016: Journal of Urology
Na N Guan, Karl Svennersten, Petra J de Verdier, N Peter Wiklund, Lars E Gustafsson
The proximal urethra and urinary bladder trigone play important roles in continence. We have previously shown that PGD2 is released from guinea pig bladder urothelium/suburothelium and can inhibit detrusor contractile responses. We presently wished to investigate PGD2 actions in guinea pig out-flow region and the distribution of DP1 /DP2 receptors. The effects of PGD2 on urothelium-intact trigone and proximal urethra contractility were studied in organ bath experiments. Expression of DP1 /DP2 receptor proteins was analysed by western blot...
September 23, 2016: Journal of Cellular and Molecular Medicine
Xun Helen Hou, Minsuk Hyun, Julian Taranda, Kee Wui Huang, Emmalee Todd, Danielle Feng, Emily Atwater, Donyell Croney, Mark Lawrence Zeidel, Pavel Osten, Bernardo Luis Sabatini
Urine release (micturition) serves an essential physiological function as well as a critical role in social communication in many animals. Here, we show a combined effect of olfaction and social hierarchy on micturition patterns in adult male mice, confirming the existence of a micturition control center that integrates pro- and anti-micturition cues. Furthermore, we demonstrate that a cluster of neurons expressing corticotropin-releasing hormone (Crh) in the pontine micturition center (PMC) is electrophysiologically distinct from their Crh-negative neighbors and sends glutamatergic projections to the spinal cord...
September 22, 2016: Cell
Nitin Joseph, Chidambara Krishnan, B Ashish Reddy, Nurul Afiqah Adnan, Low Mei Han, Yeoh Jing Min
BACKGROUND: Uterine prolapse is a common problem among women in developing countries. It is known to cause physical and psychosocial problems affecting the quality of life of patients. This study was done to determine the risk factors, clinical features, and management practices in uterine prolapse (UP). METHODS: A review of 350 case records of UP cases admitted between 2009 and 2014 was done in tertiary care hospitals. RESULTS: Mean age at presentation of UP was 52...
October 2016: Journal of Obstetrics and Gynaecology of India
Nobuyuki Mitsukawa, Yoshitaka Kubota, Shinsuke Akita, Masakazu Hasegawa, Atsuomi Saiga, Kaneshige Satoh
CASE: The patient was a 3-year-old with hypospadias. Urethroplasty was performed as a two-stage procedure, but a severe urethral stricture occurred due to a postoperative infection and the patient was virtually in urinary retention. An emergency cystostomy was performed, and thereafter urethral reconstruction was performed. A large urethral diverticulum had formed in the scrotum. The inner wall of the diverticulum was found to be completely epithelialized and well vascularized. Therefore, it was elevated as a skin flap and a neourethra was reconstructed up to the glans region using the diverticular tissue...
September 2016: Lower Urinary Tract Symptoms
Jan Krhut, Marcel Gärtner, Katarína Zvarová, Michael Desarno, Peter Zvara
OBJECTIVE: The goal of this study was to compare a novel wireless phone and web based technology to record and store overactive bladder symptoms (OAB-S) to a traditional pen and paper micturition chart. METHODS: Overactive bladder symptoms were recorded over a period of 3 days using both an electronic micturition chart (EMC) and the standard pen and paper micturition chart (MC). Twenty-nine men, with lower urinary tract symptoms (LUTS), were included in the study...
September 2016: Lower Urinary Tract Symptoms
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