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https://www.readbyqxmd.com/read/29781566/the-5-ht7-receptor-is-up-regulated-in-onuf-s-nucleus-in-rats-with-chronic-spinal-cord-injury
#1
Jianshu Ni, Nailong Cao, Xiaohu Wang, Changsheng Zhan, Jiemin Si, Baojun Gu, Karl-Erik Andersson
OBJECTIVES: To examine the effect of intrathecal 5-HT7 agonist administration on voiding function in urethane-anesthetized rat, and the change of 5-HT7 receptor expression in lumbosacral cord Onuf's nucleus after SCI. MATERIALS AND METHODS: Thirty-two female Sprague-Dawley (SD) rats were divided into spinally intact (SI) group and SCI group (n=16 each). Eight weeks after transection, half of the rats underwent continuous cystometry under urethane anesthetization, and the 5-HT7 selective agonist LP44 was given intrathecally...
May 21, 2018: BJU International
https://www.readbyqxmd.com/read/29781068/pelvic-floor-muscle-training-with-or-without-tibial-nerve-stimulation-and-lifestyle-changes-have-comparable-effects-on-the-overactive-bladder-a-randomized-clinical-trial
#2
Lina Bykoviene, Raimondas Kubilius, Rosita Aniuliene, Egle Bartuseviciene, Arnoldas Bartusevicius
PURPOSE: To compare effects of transcutaneous posterior tibial nerve stimulation (TPTNS) and pelvic floor muscle training (PFMT) in women with overactive bladder syndrome (OAB). MATERIAL AND METHODS: We randomized 67 women ? 18 years with OAB to three parallel groups: group I (n = 22) received life-style recommendations (LSR) only; group II (n = 24) had LSR + PFMT and group III (n = 21) had LSR + PFMT + TPTNS. Urgency, evaluated by a 3-day voiding diary before treatment and six weeks later, was the main outcome measure...
May 21, 2018: Urology Journal
https://www.readbyqxmd.com/read/29772579/antenatal-workup-of-early-megacystis-and-selection-of-candidates-for-fetal-therapy
#3
Federica Fontanella, Leonie Duin, Phebe N Adama van Scheltema, Titia E Cohen-Overbeek, Eva Pajkrt, Mireille Bekker, Christine Willekes, Caroline J Bax, Dick Oepkes, Catia M Bilardo
OBJECTIVE: To investigate the best criteria for discriminating fetuses with isolated posterior urethral valves from those theoretically not eligible for fetal treatment because of complex megacystis, high chance of spontaneous resolution, and urethral atresia. METHODS: A retrospective national study was conducted in fetuses with megacystis detected before 17 weeks' gestation (early megacystis). RESULTS: In total, 142 cases with fetal megacystis were included in the study: 52 with lower urinary tract obstruction, 29 with normal micturition at birth, and 61 with miscellaneous syndromal associations, chromosomal and multiple structural abnormalities (complex megacystis)...
May 17, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29766654/prospective-short-term-feasibility-study-of-perioperative-suprapubic-catheters-in-laparoscopic-colectomy
#4
Sayaka Nagao, Yoshihisa Saida, Toshiyuki Enomoto, Asako Takahashi, Tadashi Higuchi, Hodaka Moriyama, Toru Niituma, Manabu Watanabe, Koji Asai, Shinya Kusachi
INTRODUCTION: Here we report a prospective study on whether a temporary suprapubic catheter (SPC) can be safely inserted as a substitute for transurethral balloon catheterization during laparoscopy-assisted colectomy. METHODS: Our subjects included 52 cases who gave informed consent to have an SPC inserted. These subjects were selected from cases who underwent laparoscopy-assisted surgery for primary colorectal cancer from October 2014 to August 2015. RESULTS: An SPC was inserted into 45 of the original 52 cases...
May 16, 2018: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29766266/-syncope-and-fitness-to-drive
#5
REVIEW
Hermann H Klein
Although medical students are rarely instructed in traffic medicine in Germany, they are obliged to inform their patients about their fitness to drive after having become a medical doctor. This article gives an overview on the fitness to drive for patients with syncope by referring to the driving license regulation and the current guidelines released by the department of traffic. The driving license regulation distinguishes between group 1 and group 2 drivers. Group 1 drivers drive vehicles with a total weight less than 3...
May 15, 2018: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/29760663/suppression-of-urinary-voiding-by-conditional-high-frequency-stimulation-of-the-pelvic-nerve-in-conscious-rats
#6
Charly B J Brouillard, Jonathan J Crook, Pedro P Irazoqui, Thelma A Lovick
Female Wistar rats were instrumented to record bladder pressure and to stimulate the left pelvic nerve. Repeated voids were induced by continuous infusion of saline into the bladder (11.2 ml/h) via a T-piece in the line to the bladder catheter. In each animal tested ( n = 6) high frequency pelvic nerve stimulation (1-3 kHz, 1-2 mA sinusoidal waveform for 60 s) applied within 2 s of the onset of a sharp rise in bladder pressure signaling an imminent void was able to inhibit micturition. Voiding was modulated in three ways: (1) Suppression of voiding (four rats, n = 13 trials)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29760175/modulation-of-receptor-protein-tyrosine-phosphatase-sigma-increases-chondroitin-sulfate-proteoglycan-degradation-through-cathepsin-b-secretion-to-enhance-axon-outgrowth
#7
Amanda Phuong Tran, Sapna Sundar, Meigen Yu, Bradley T Lang, Jerry Silver
Severed axon tips reform growth cones following spinal cord injury that fail to regenerate, in part, because they become embedded within an inhibitory extracellular matrix. Chondroitin sulfate proteoglycans (CSPGs) are the major axon inhibitory matrix component that is increased within the lesion scar and in perineuronal nets around deafferented neurons. We have recently developed a novel peptide modulator (Intracellular Sigma Peptide or ISP) of the cognate receptor of CSPGs, protein tyrosine phosphatase sigma (RPTPσ), which has been shown to markedly improve sensorimotor function, micturition, and coordinated locomotor behavior in spinal cord contused rats...
May 14, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29753213/onabotulinumtoxina-detrusor-injection-improves-female-sexual-function-in-women-with-overactive-bladder-wet-syndrome
#8
Matteo Balzarro, Emanuele Rubilotta, Andrea Braga, Silvia Bassi, Tania Processali, Walter Artibani, Maurizio Serati
OBJECTIVES: The correlation between changes in sexual function and improvements in LUTD in patients treated with OnabotulinumtoxinA (onaBoNT-A) detrusor injection is unclear and limited only to women with neurogenic OAB. The aim of this study was to evaluate the impact of OnabotulinumtoxinA (onaBoNT-A) injection on sexual function in women undergoing this treatment for idiopathic wet overactive bladder (OAB). STUDY DESIGN: This is a pilot three-center observational study including women affected by idiopathic wet overactive bladder refractory to standard conservative treatments and underwent onaBoNT-A injection...
May 5, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29752971/metabolomic-analysis-of-overactive-bladder-in-male-patients-identification-of-potential-metabolite-biomarkers
#9
Hiroshi Shimura, Takahiko Mitsui, Satoru Kira, Tatsuya Ihara, Norifumi Sawada, Hiroshi Nakagomi, Tatsuya Miyamoto, Sachiko Tsuchiya, Mie Kanda, Masayuki Takeda
OBJECTIVES: To identify metabolites that are associated with an overactive bladder (OAB) using metabolomics. PATIENTS AND METHODS: A total of 58 males without apparent neurological disease completed 24-hr bladder diaries of their micturition behavior and International Prostate Symptom Score (IPSS) for the assessment of micturition behavior and lower urinary tract symptoms. Urgency was defined as an IPSS urgency score of ≥2 (OAB group), and patients with IPSS urgency scores of ≤1 belonged to the control group...
May 9, 2018: Urology
https://www.readbyqxmd.com/read/29752752/long-term-safety-and-efficacy-of-the-novel-%C3%AE-3-adrenoreceptor-agonist-vibegron-in-japanese-patients-with-overactive-bladder-a-phase-iii-prospective-study
#10
Masaki Yoshida, Hidehiro Kakizaki, Satoru Takahashi, Shinji Nagai, Takafumi Kurose
OBJECTIVES: To evaluate the long-term safety and efficacy of vibegron 50 mg and 100 mg, a novel β3 -adrenoreceptor agonist, in Japanese patients with overactive bladder. METHODS: This was a 1-year, multicenter, open-label, non-controlled study. After a 1-week observation phase, patients were treated with vibegron for 52 weeks. When the efficacy was insufficient after an 8-week treatment with 50 mg, the dose was increased to 100 mg and maintained for an additional 44 weeks...
May 11, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29752515/epidemiology-and-pathophysiology-of-neurogenic-bladder-after-spinal-cord-injury
#11
Rizwan Hamid, Marcio Augusto Averbeck, Humberto Chiang, Arturo Garcia, Riyad T Al Mousa, Seung-June Oh, Anita Patel, Mauricio Plata, Giulio Del Popolo
Spinal cord injury (SCI) usually affects younger age groups with male preponderance. The most common traumatic cause is road traffic accident followed by sports accidents and gun-shot injuries. Infections and vascular events make up non-traumatic causes. There is regional variance in incidence and prevalence of SCI. Most systematic reviews have been undertaken from USA, Canada, and Australia with only few from Asia with resultant difficulty in estimation of worldwide figures. Overall, the incidence varies from 12 to more than 65 cases/million per year...
May 11, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29737234/biofabricated-structures-reconstruct-functional-urinary-bladders-in-radiation-injured-rat-bladders
#12
Tetsuya Imamura, Mitsuru Shimamura, Teruyuki Ogawa, Tomonori Minagawa, Takashi Nagai, Sudha Silwal Gautam, Osamu Ishizuka
The ability to repair damaged urinary bladders through the application of bone marrow-derived cells is in the earliest stages of development. We investigated the application of bone marrow-derived cells to repair radiation-injured bladders. We used a three-dimensional (3D) bioprinting robot system to biofabricate bone marrow-derived cell structures. We then determined if the biofabricated structures could restore the tissues and functions of radiation-injured bladders. The bladders of female 10-week-old Sprague-Dawley (SD) rats were irradiated with 2-Gy once a week for 5 weeks...
May 8, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29732215/a-ligamentous-explanation-for-overactive-bladder-symptoms-as-defined-by-international-continence-society-in-the-female
#13
REVIEW
Peter Petros
The International Continence Society (ICS) committee has defined overactive bladder (OAB) as "a syndrome characterized by symptoms of urgency, with or without urgency incontinence, usually with increased daytime frequency and nocturia (increased night time urination). The term OAB can only be used if there is no proven infection or other obvious pathology". Though the ICS gives no anatomical basis for OAB, it is suggested that the cause is from the detrusor itself. In this review, urodynamic evidence is presented that OAB in the female may be a prematurely activated but normal micturition reflex, as predicted by the Integral Theory...
2018: Central European Journal of Urology
https://www.readbyqxmd.com/read/29730838/thulium-vapoenucleation-of-the-prostate-versus-holmium-laser-enucleation-of-the-prostate-for-the-treatment-of-large-volume-prostates-preliminary-6-month-safety-and-efficacy-results-of-a-prospective-randomized-trial
#14
B Becker, T R W Herrmann, A J Gross, C Netsch
PURPOSE: We compared the perioperative and postoperative characteristics of thulium vapoenucleation and holmium laser enucleation of the prostate for the treatment of large volume benign prostatic hyperplasia. MATERIALS AND METHODS: A total of 94 patients with benign prostatic hyperplasia and a median prostate size of 80 (IQR 46.75-100) cc were either randomized to thulium vapoenucleation or holmium laser enucleation of the prostate. Patients were assessed preoperatively, 1 and 6 months postoperatively...
May 5, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29728445/micturition-and-defecation-elicited-by-lys5-meleu9-nle10-nka-4-10-in-conscious-dogs
#15
Nadia Rupniak, Mary Katofiasc, Alexander Walz, Karl B Thor, Edward C Burgard
Tachykinin NK2 receptor agonists may have potential to alleviate clinical conditions associated with bladder and gastrointestinal under-activity by stimulating contraction of visceral smooth muscle. The ability of [Lys5,MeLeu9,Nle10]-NKA(4-10) (LMN-NKA) to elicit micturition and defecation was examined after repeated administration in groups of 2-10 conscious dogs. Administration of 10-100 μg/kg i.v., 4 times daily for 6 consecutive days, reliably elicited micturition after >90% of doses and defecation after >50% of doses...
May 4, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29727542/-3-1-bladder-function-restoration-combined-with-holmium-laser-enucleation-of-the-prostate-for-benign-prostatic-hyperplasia-with-acontractile-detrusor
#16
Xiang Wan, Chong Liu, Huan Xu, Meng Gu, Yan-Bo Chen, Yu-Bing Peng, Qi Chen, Zhi-Kang Cai, Zhong Wang
Objective: To investigate the clinical effect of "3+1" bladder function restoration combined with holmium laser enucleation of the prostate (HoLEP) in the treatment of benign prostatic hyperplasia (BPH) with acontractile detrusor (ACD). METHODS: We treated 35 BPH patients with ACD by HoLEP followed by "3+1" bladder function restoration, that is, a 3-phase bladder function training plus simultaneous 1-drug medication after surgery. We recorded and analyzed the detrusor pressure, post-void residual urine volume (PVR), maximum urinary flow rate (Qmax), International Prognostic Scoring System (IPSS) scores, quality of life (QoL), voluntary micturition, satisfaction with the bladder function, hydronephrosis, ureterectasia, renal function, and urinary tract infection of the patients before and after treatment...
October 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29726640/-establishment-of-a-penile-transplantation-model-in-beagle-dogs
#17
Yong-Bin Zhao, Wei-Lie Hu, Li-Chao Zhang, Jun Liu, Chang-Zheng Zhang, Bang-Qi Wang, Yuan-Song Xiao, Hui Hu, Ming Ying
Objective: To investigate the feasibility of establishing a model of allograft penile transplantation in adult beagle dogs and explore the conditions for constructing a stable animal model of penis transplant. METHODS: Following the principles of similarity, repeatability, feasibility, applicability, and controllability in the construction of experimental animal models, we compared the major anatomic features of the penis of 20 adult beagle dogs with those of 10 adult men...
August 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29717937/deletion-or-pharmacological-blockade-of-toll-like-receptor-4-tlr4-confers-protection-against-cyclophosphamide-induced-mouse-cystitis
#18
Mariana G de Oliveira, Fabiola Zakia Mónica, Fabiano B Calmasini, Eduardo C Alexandre, Edith B G Tavares, Antonio G Soares, Soraia K P Costa, Edson Antunes
Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a chronic inflammatory disease without consistently effective treatment. We investigate the role of toll-like receptor (TLR4) on voiding dysfunction and inflammation in the cyclophosphamide (CYP)-induced mouse cystitis. Males C57BL/6 (wild-type, WT) and/or TLR4 knockout (TLR4-/-) were treated with an injection of CYP (300 mg/kg, 24 h) or saline (10 ml/kg). The pharmacological blockade of the TLR4 by resatorvid (10 mg/kg) was also performed 1 h prior CYP-injection in WT mice...
May 2, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29712492/a-critical-review-on-the-concept-of-avapeedaka-snehapana-a-special-mode-of-lipid-administration
#19
P B Kadambari, Prasanth Dharmarajan, C K Prathibha, P V Anandaraman
Avapeedaka Snehapana is a unique and special method of internal administration of Sneha dravya (unctuous medicine) mentioned in the classical ayurveda texts. It is mainly indicated in mutravegarodha janya vikara (diseases due to the suppression of urge of micturition). Because of the lack of adequate review and analysis, this method of administration of snehapana (internal administration of lipid) is losing its significance from the practices and the concept remains unexplored. The reasons for not being practiced like other snehana (oleation therapy) procedures are because of the less understanding of the concept of administration, scattered and minimal textual references...
January 2018: Journal of evidence-based integrative medicine
https://www.readbyqxmd.com/read/29699858/efficacy-and-tolerability-of-mirabegron-compared-with-antimuscarinic-monotherapy-or-combination-therapies-for-overactive-bladder-a-systematic-review-and-network-meta-analysis
#20
Con Kelleher, Zalmai Hakimi, Richard Zur, Emad Siddiqui, Khaled Maman, Samuel Aballéa, Jameel Nazir, Chris Chapple
BACKGROUND: Mirabegron is an established treatment alternative to antimuscarinic therapy for patients with overactive bladder (OAB), as shown by efficacy and tolerability data from phase III trials. OBJECTIVE: To assess efficacy and tolerability of mirabegron 50mg versus antimuscarinic monotherapies and combination therapies. DESIGN, SETTING, AND PARTICIPANTS: Systematic literature review and network meta-analysis of randomised controlled trials (2000-2017) assessing eligible treatments for OAB...
April 23, 2018: European Urology
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