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https://www.readbyqxmd.com/read/28220521/indirect-treatment-comparison-itc-of-medical-therapies-for-an-overactive-bladder
#1
Aneta Obloza, Joshua Kirby, Derrick Yates, Philip Toozs-Hobson
BACKGROUND: Overactive bladder syndrome (OAB) is a chronic and prevalent condition which has a negative impact on Quality of Life. The National Institute of Clinical Excellence issued two documents which give slightly varying algorithms of pharmacotherapy for OAB, offering mirabegron as a possible treatment in certain circumstances. In the absence of trials involving a direct comparison of therapies, an indirect comparison can provide useful information on the difference in treatment effects between competing interventions...
February 21, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28220212/rho-kinase-inhibition-ameliorates-cyclophosphamide-induced-cystitis-in-rats
#2
Andrzej Wróbel, Urszula Doboszewska, Ewa Rechberger, Karol Rojek, Anna Serefko, Ewa Poleszak, Krystyna Skalicka-Woźniak, Jarosław Dudka, Piotr Wlaź
Hemorrhagic cystitis often develops in patients treated with cyclophosphamide (CYP). Studies have indicated that Rho kinase (ROCK) inhibitors may suppress detrusor overactivity symptoms and possess anti-inflammatory properties. The aim of the present study was to investigate whether inhibition of ROCK reduces cystometric and histopathological changes associated with CYP-induced cystitis. The rats received GSK 269962, a ROCK inhibitor, at a dose of 30 mg/kg daily, or vehicle for 7 days. Then, acute chemical cystitis leading to bladder overactivity was induced by CYP injection (200 mg/kg i...
February 21, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28217761/modeling-of-chronic-radiation-induced-cystitis-in-mice
#3
Bernadette M M Zwaans, Sarah Krueger, Sarah N Bartolone, Michael B Chancellor, Brian Marples, Laura E Lamb
PURPOSE: Radiation cystitis (RC), a severe inflammatory bladder condition, develops as a side-effect of pelvic radiation therapy in cancer patients. There are currently no effective therapies to treat RC, in part due to the lack of preclinical model systems. In this study, we developed a mouse model for RC and used a small animal radiation research platform (SARRP) to simulate the targeted delivery of radiation as used with human patients. METHODS AND MATERIALS: To induce RC, C3H mice received a single radiation dose of 20Gy delivered through two beams...
October 2016: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28217452/a-review-of-penile-elongation-surgery
#4
REVIEW
Jeffrey Campbell, Joshua Gillis
Penile elongation surgery is less commonly performed in the public sector, but involves a collaborative approach between urology and plastic surgery. Congenital and acquired micropenis are the classic surgical indications for penile elongation surgery. The goal of intervention in these patients is to restore a functional penis size in order to allow normal standing micturition, enable satisfying sexual intercourse and improve patient quality of life. Many men seeking elongation actually have normal length penises, but perceive themselves to be small, a psychologic condition termed 'penile dysmorphophobia'...
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28211556/occurrence-of-selected-lower-urinary-tract-symptoms-in-patientsof-a-day-hospital-for-neurotic-disorders
#5
Jerzy A Sobański, Michał Skalski, Tomasz Gołąbek, Agata Świerkosz, Mikołaj Przydacz, Katarzyna Klasa, Krzysztof Rutkowski, Edyta Dembińska, Michał Mielimąka, Katarzyna Cyranka, Piotr L Chłosta, Dominika Dudek
OBJECTIVES: To assess the occurrence of selected lower urinary tract symptoms in the population of patients with neurotic and personality disorders. METHODS: This was a retrospective analysis of occurrence, co-existence and severity of two selected lower urinary tract symptoms in 3,929 patients in a day hospital for neurotic disorders. The KO "O" symptom checklist was used to measure the study variables. RESULTS: Although the symptoms associated with micturition are not the most prevalent symptoms of neurotic disorders, neither are they the most typical ones, the prevalence of urinary frequency referring to the last week before psychotherapy evaluated among the patients of a day hospital, was approximately 50%...
December 23, 2016: Psychiatria Polska
https://www.readbyqxmd.com/read/28194560/a-comparative-study-of-electroacupuncture-at-zhongliao-bl33-and-other-acupoints-for-overactive-bladder-symptoms
#6
Likun Yang, Yang Wang, Qian Mo, Zhishun Liu
Electroacupuncture (EA) at Zhongliao (BL33) can improve the symptoms of overactive bladder (OAB), such as urinary frequency, urgency, and incontinence. However, its performance compared with other acupoints remains unclear. This study investigated the effects of EA at BL33 with deep needling on rats with OAB by detecting urodynamics in eight groups: no intervention group, D-BL33 group (deep needling at BL33), S-BL33 group (shallow needling at BL33), non-acupoint group (needling at the non-acupoint next to BL33), Weizhong (BL40) group, Sanyinjiao (SP6) group, Tongtian (BL7) group, and Hegu (LI4) group...
February 14, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28190530/prevalence-and-characteristics-of-urinary-incontinence-in-a-cohort-of%C3%A2-patients-with-chronic-heart-failure
#7
Kerry Poole, Monica Kerlin, Rochelle Wynne
BACKGROUND: Evidence describing the characteristics of urinary incontinence (UI) in patients with chronic heart failure (CHF), and the impact of this combination of conditions on functional status and quality of life, is limited. OBJECTIVE: The primary aim of this study was to determine the prevalence and characteristics of UI in a cohort of CHF patients. METHODS: A prospective survey of 100 outpatients with CHF was undertaken. RESULTS: There were 43 (65...
February 9, 2017: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/28188760/long-term-clinical-efficacy-and-safety-profile-of-transurethral-resection-of-prostate-vs-plasmakinetic-resection-of-the-prostate-for-benign-prostatic-hyperplasia
#8
Zhe Liu, Yuan Wei Li, Wan Rui Wu, Qiang Lu
OBJECTIVE: To investigate differences on clinical efficacy, complications and safety profile between transurethral resection of prostate (TURP) and bipolar plasmakinetic resection of the prostate (PKRP) for benign prostatic hyperplasia (BPH). METHODS: 690 patients of BPH were recruited from May 2008 to May 2011 and divided into TURP group and PKRP group, IPSS, QoL, PVR, Qmax, complications, IIEF-5 and retrograde ejaculation were used for evaluation of clinical effective, safety and sexual function between two groups...
February 8, 2017: Urology
https://www.readbyqxmd.com/read/28169992/incontinence-optogenetics-enables-control-of-micturition
#9
Peter Sidaway
No abstract text is available yet for this article.
February 7, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28169451/an-optimized-transurethral-catheterization-cystometry-in-mice-and-comparison-with-classic-suprapubic-catheterization-cystometry
#10
Zhuoyi Xiang, Yaohui Li, Tingchang Bian, Minke He, Yeqing Xu, Guomin Wang, Jianming Guo, Hang Wang
AIMS: The aim of this study is to establish an optimized, minimally invasive transurethral catheterization cystometry (TUCC) and a novel urethral pressure profile (UPP) measurement for mice. METHODS: The optimized TUCC and the UPP measurement were first established. This optimized TUCC was then performed in 16 anesthetized female mice and compared with the suprapubic catheterization cystometry (SCC) in parallel after suprapubic catheters implantation (SCI; on zero, third, and seventh day, respectively)...
February 7, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28150436/efficacy-and-safety-of-gabapentin-in-comparison-to-solifenacin-succinate-in-adult-overactive-bladder-treatment
#11
Michael E Chua, Manuel C See, Ednalyn B Esmeňa, Jaime C Balingit, Marcelino L Morales
OBJECTIVE: To evaluate the efficacy and safety of gabapentin in comparison to solifenacin succinate and placebo for the treatment of adult patients with overactive bladder (OAB). METHOD: A 12-week, randomized, double-blind, double dummy placebo-controlled, clinical trial was conducted between October 2010 and August 2014 at a tertiary medical center. Eligible and consenting patients included were randomized into three treatment groups (placebo, gabapentin and solifenacin)...
February 2, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28149750/pheochromocytoma-a-cause-of-anemia
#12
A Youssef, A Hamade
Patients with a Pheochromocytoma usually present with intractable hypertension, postural hypotension, headaches and palpitations, with intractable hypertension being the predominant symptom. When the tumor is located in the urinary bladder, symptoms may be induced by micturition. Herein, we report a young patient with a urinary bladder Pheochromocytoma without hypertension or symptoms induced by micturition. Instead, she presented with anemia.
February 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28147376/solifenacin-in-the-elderly-results-of-an-observational-study-measuring-efficacy-tolerability-and-cognitive-effects
#13
Christian Hampel, Dietmar Betz, Maximilian Burger, Christoph Nowak, Monika Vogel
INTRODUCTION: The study aimed to evaluate the efficacy and safety of solifenacin in older patients with overactive bladder (OAB). MATERIALS AND METHODS: Observational data on patients aged ≥70 years and the prescribed flexible dose of solifenacin for OAB were collected at 294 offices of German general practitioners. Baseline and week 12 data included type and severity of OAB symptoms, adverse events, quality of life, and change in cognitive function per Mini Mental State Examination (MMSE)...
February 2, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28127377/synovial-chondromatosis-of-dorsal-spine-case-report-of-rare-pathological-entity-and-review
#14
Raviraj S Ghorpade, Yadhu K Lokanath
Synovial chondromatosis is an uncommon benign condition of metaplastic and focal formation of cartilage in the intimal layer of synovial membrane of joints with extremely low risk of malignant potential. Disease process is typically monoarticular predominantly involving large joints and spinal involvement being a very rare event. We report 31-year-old male patient who presented with history of low backache, left lower limb pain, difficulty in micturition since 8 months and difficulty in walking since 2 months ...
December 2016: Korean Journal of Spine
https://www.readbyqxmd.com/read/28127134/inhaler-syncope
#15
Robert L Rosenthal, Jay O Franklin
Syncope can result from certain activities that trigger an exaggerated physiological response in susceptible individuals; examples include cough, laugh, and micturition syncope. We report a novel cause for syncope, that due to reflex bradycardia and asystole produced by the use of asthma inhalers. We discuss the possible mechanisms for this effect and briefly review other breathing-related causes of bradycardia.
January 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28124536/a-prospective-randomized-controlled-multicentre-trial-comparing-intravesical-dmso-and-chondro%C3%A3-tin-sulphate-2-for-painful-bladder-syndrome-interstitial-cystitis
#16
Manuela Tutolo, Enrico Ammirati, Giulia Castagna, Katrien Klockaerts, Hendrik Plancke, Dieter Ost, Frank Van der Aa, Dirk De Ridder
OBJECTIVE: To compare effectiveness of intravesical chondroïtin sulphate (CS) 2% and dimethyl sulphoxide (DMSO) 50% in patients with painful bladder syndrome/interstitial cystitis (PBS/IC). MATERIALS AND METHODS: Patients were randomized to receive either 6 weekly instillations of CS 2% or 50% DMSO. Primary endpoint was difference in proportion of patients achieving score 6 (moderately improved) or 7 (markedly improved) in both groups using the Global Response Assessment (GRA) scale...
January 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28124534/percutaneous-tibial-nerve-stimulation-versus-electrical-stimulation-with-pelvic-floor-muscle-training-for-overactive-bladder-syndrome-in-women-results-of-a-randomized-controlled-study
#17
Carlo Vecchioli Scaldazza, Carolina Morosetti, Rosita Giampieretti, Rossana Lorenzetti, Marinella Baroni
INTRODUCTION: This study compared percutaneous tibial nerve stimulation (PTNS) versus electrical stimulation with pelvic floor muscle training (ES + PFMT) in women with overactive bladder syndrome (OAB). MATERIALS AND METHODS: 60 women with OAB were enrolled. Patients were randomized into two groups. In group A, women underwent ES with PFMT, in group B women underwent PTNS. RESULTS: A statistically significant reduction in the number of daily micturitions, episodes of nocturia and urge incontinence was found in the two groups but the difference was more substantial in women treated with PTNS; voided volume increased in both groups...
January 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28124533/cystometric-analysis-of-the-transplanted-bladder
#18
Jeová Nina Rocha
OBJECTIVE: cystometric evaluation of the bladder after autotransplant and isogeneic transplant in female rats. MATERIAL AND METHODS: two groups were constituted: (A) bladder autotransplant with two subgroups: R1 - (control) and R2 - (bladder transplant); (B) isogeneic bladder transplant with three subgroups; T1 - (control); T2-T3, two subgroups observed for 30 and 60 days after transplant, respectively. All animals underwent cystometric evaluation. Afterwards, the bladders were removed for histological study...
January 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28122392/radical-prostatectomy-restores-detrusor-contraction-pattern-according-to-pressure-flow-parameters
#19
Takeya Kitta, Yukiko Kanno, Hiroki Chiba, Kimihiko Moriya, Satoru Maruyama, Takashige Abe, Nobuo Shinohara
OBJECTIVES: Pressure flow studies are regarded as the gold standard for evaluating both bladder outlet obstruction and detrusor contractility, but none of the current methods for evaluating bladder contraction patterns are well validated. Impaired bladder contraction results in a lower peak Watts factor and poorly sustained detrusor contractions. From this viewpoint, the maximum Watts factor and its pattern should be considered separately. To examine detrusor contraction pattern in patients after radical prostatectomy by using multiple parameters...
January 25, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28122140/disorders-of-micturition-in-small-animal-patients-clinical-significance-etiologies-and-management-strategies
#20
Eric Langfitt, Jennifer E Prittie, Yekaterina Buriko, Janine M Calabro
OBJECTIVES: To review the physiology of micturition, the pathophysiology of micturition disorders, and current pharmacological agents used to treat these disorders. To discuss different urinary catheterization techniques, along with the risks of catheter-associated urinary tract infections attributed with these techniques. ETIOLOGY: Many critically ill veterinary patients are at risk of developing a number of neurological and non neurological micturition-related disorders...
January 25, 2017: Journal of Veterinary Emergency and Critical Care
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