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Micturition

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https://www.readbyqxmd.com/read/28340519/barrington-s-nucleus-neuroanatomic-landscape-of-the-mouse-pontine-micturition-center
#1
Anne M J Verstegen, Veronique Vanderhorst, Paul A Gray, Mark L Zeidel, Joel C Geerling
Barrington's nucleus (Bar) is thought to contain neurons that trigger voiding and thereby function as the "pontine micturition center." Lacking detailed information on this region in mice, we examined gene and protein markers to characterize Bar and the neurons surrounding it. Like rats and cats, mice have an ovoid core of medium-sized Bar neurons located medial to the locus coeruleus (LC). Bar neurons express a GFP reporter for Vglut2, develop from a Math1/Atoh1 lineage, and exhibit immunoreactivity for NeuN...
March 24, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28322961/galactoglucomannan-rich-hemicellulose-extract-from-norway-spruce-picea-abies-exerts-beneficial-effects-on-chronic-prostatic-inflammation-and-lower-urinary-tract-symptoms-in-vivo
#2
Konkol Yvonne, Vuorikoski Heikki, Tuomela Johanna, Holmbom Bjarne, Bernoulli Jenni
Galactoglucomannan (GGM) is the main hemicellulose class in wood of coniferous trees and could be potentially utilized as a possible health-promoting substance for food and pharmaceutical industry. Our aim was to evaluate effects of orally administered GGM-rich extract from Norway spruce in a rat model of chronic prostatitis associated with lower urinary tract symptoms (LUTS). Prostatic inflammation and LUTS was induced in male rats using testosterone and 17β-estradiol exposure for 18 weeks. Rats were treated with 2% GGM dissolved in drinking water during weeks 13-18...
March 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28302238/gitelman-syndrome
#3
Qurat Ul Ain Mustafa, Zujaja Hina Haroon, Aamir Ijaz, Muhammad Tanveer Sajid, Muhammad Ayyub
Gitelman syndrome (GS) is the most frequently inherited renal salt-wasting tubulointerstitial disease. It follows variable but usually asymptomatic benign course. We present a rare case of GS that remained clinical enigma. A 22-year male presented with severe episodic fatigue involving all limbs associated with episodes of sinking, palpitations, salt craving, increased thirst and frequent micturition hampering his routine daily activities. Laboratory workup revealed serum potassium, 2.7 mmol/L, serum magnesium, 0...
March 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28293500/a-systematic-review-of-metoidioplasty-and-radial-forearm-flap-phalloplasty-in-female-to-male-transgender-genital-reconstruction-is-the-ideal-neophallus-an-achievable-goal
#4
Jordan D Frey, Grace Poudrier, Michael V Chiodo, Alexes Hazen
INTRODUCTION: The complex anatomy and function of the native penis is difficult to surgically replicate. Metoidioplasty and radial forearm flap phalloplasty (RFFP) are the 2 most commonly utilized procedures for transgender neophallus construction. METHODS: A MEDLINE search for metoidioplasty and RFFP in female-to-male genital reconstruction was performed. Primary outcome measures were subsequently compared. A systematic review was planned in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyse guidelines...
December 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28276096/central-control-of-micturition-in-women-brain-bladder-pathways-in-continence-and-urgency-urinary-incontinence
#5
REVIEW
Nisha G Arya, Steven J Weissbart
Urinary incontinence disproportionately affects women. Anatomical textbooks typically describe continence mechanisms in women in the context of the pelvic floor support of the urinary bladder and the urethral sphincters. However, the urinary bladder and urethral sphincters are under the central control of the brain through a complex network of neurons that allow storage of urine followed by voiding when socially appropriate. Recent studies suggest that the most common type of urinary incontinence in women, urgency urinary incontinence, involves significant dysfunction of the central control of micturition...
April 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28267560/neurogenic-bladder-dysfunction-does-not-correlate-with-astrocyte-and-microglia-activation-produced-by-graded-force-in-a-contusion-induced-spinal-cord-injury
#6
Alvaro Munoz
Rodent models for the study of neurogenic bladder dysfunction after spinal cord injury (SCI) are difficult to standardize, particularly when evaluating the specific contribution of the SCI to end-organ function. The purpose of this study was to evaluate the degree of bladder dysfunction associated with a highly reproducible, contusion-induced SCI in female rats. An infinite horizon impactor was used to create a contusion SCI with a magnitude of either 100 or 150 kDyne at the T8/T9 thoracic region of female Sprague-Dawley rats...
March 3, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28254462/fatty-acid-amide-hydrolase-inhibitor-treatment-in-men-with-chronic-prostatitis-chronic-pelvic-pain-syndrome-an-adaptive-double-blind-randomized-controlled-trial
#7
Florian M E Wagenlehner, J W Olivier van Till, Jos G A Houbiers, Reynaldo V Martina, Dirk P Cerneus, Joost H J M Melis, Antoni Majek, Egils Vjaters, Michael Urban, Henrikas Ramonas, Daniel A Shoskes, J Curtis Nickel
OBJECTIVE: To examine the effect of a peripherally active fatty acid amide hydrolase (FAAH) inhibitor ASP3652 on safety and efficacy outcomes in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Inhibition of FAAH is hypothesized to reduce the excitability of urinary tract afferents including nociceptors. MATERIALS AND METHODS: In this adaptive, randomized, double-blind, placebo-controlled study, adult male patients with moderate to severe CP/CPPS were treated for 12 weeks with an oral dose of ASP3652 (25, 75, 150, or 300 mg twice daily, or 300 mg once daily), or placebo...
February 27, 2017: Urology
https://www.readbyqxmd.com/read/28252310/-degree-of-satisfaction-of-patients-continuing-overactive-bladder-treatment-with-mirabegron
#8
K Švabík, J Mašata, J Krhut, R Zachoval, T Hanuš, M Halaška, L Horčička, L Krofta, M Hanáková, A Martan
OBJECTIVE: Overactive bladder syndrome is chronic disease with high prevalence rate (9-42%). This syndrome requires long term therapy, but the treatment persistence is after 3 months over all 26% with further decline in one-year period as low as 18.5%. Main reasons for stopping the treatment are low efficacy, the medication didnt work as expected and side effects. How much satisfied are patients with mirabegron persisting on its treatment? To answer this question, we provided secondary analysis of multicentre follow-up study of patients on mirabegron...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/28248039/-association-of-lower-urinary-tract-symptoms-and-testosterone-deficiency-in-men-with-type-2-diabetes
#9
M I Kogan, I I Belousov, H S Ibishev, A A Cherniy, I A Khripun, S V Vorobyev, D V Sizjakin
INTRODUCTION AND OBJECTIVES: Type 2 diabetes mellitus, as a chronic systemic metabolic disease, is widely spread in the population of middle- aged men. Previously it has been proven the link between the presence of type 2 diabetes and the development of lower urinary tract symptoms in men. At the same time, middle-aged men are characterized by the appearance and progression of benign prostatic hyperplasia. MATERIAL AND METHODS: We performed a study of middle-aged men with type 2 diabetes to determine the interrelation of micturition disorders with deficiency of serum testosterone, in respect that the pathophysiology of prostatic hyperplasia is regarded as dysmetabolic dyshormonal state...
December 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28248017/-quality-of-life-as-an-effectiveness-criterion-of-surgical-treatment-for-anterior-urethral-strictures
#10
A N Shibaev, V V Bazaev, Yu V Pavlova
RELEVANCE: Recent trends in the contemporary medicine have shown a growing request for the personalized choice of treatment and evaluation of its results. PROM-USS questionnaire has been designed for patients undergoing surgical correction of anterior urethral strictures to measure the treatment success using patient reported outcomes in numerical terms. AIM: To test the effectiveness of different surgical modalities for anterior urethral strictures using patient reported outcomes...
November 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28248016/-ipss-qol-questionnaire-in-assessing-symptoms-and-quality-of-life-in-patients-with-anterior-urethral-stricture
#11
V V Bazaev, A N Shibaev, Yu V Pavlova
RELEVANCE: The IPSS-QOL questionnaire is frequently used to assess symptoms and quality of life of men with urethral strictures. However, the psychometric properties of the questionnaire in assessing these patients have not been evaluated. AIM: To test the psychometric properties of the IPSS-QoL questionnaire in assessing patients with anterior urethral strictures. MATERIAL AND METHODS: Thirty five men with anterior urethral strictures self-completed the IPSS-QoL questionnaire...
November 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28247647/-epidemiology-of-urinary-disorders-in-men-in-the-russian-federation
#12
I A Korneev, T A Alekseeva, M I Kogan, D Yu Pushkar'
AIM: To compare the results of population studies conducted in the Russian Federation to identify the prevalence, severity and risk factors for urinary disorders in men. MATERIALS AND METHODS: Data of a survey of 1083 men were analyzed for the age, weight, height, comorbidities with their signs and symptoms, history of surgery on pelvic organs, copulative disorders, and IPSS and quality of life scores. The findings were compared with the results of a survey of 482 Russian men under the protocol of the International Society of Continence (ICS) aimed to identify patients with overactive bladder (OAB), in whom pollakiuria, nocturia, urgency, urinary incontinence, stress-incontinence, poor flow and terminal dribbling were registered...
April 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28244642/carbenoxolone-inhibits-trpv4-channel-initiated-oxidative-urothelial-injury-and-ameliorates-cyclophosphamide-induced-bladder-dysfunction
#13
Xiling Zhang, Shan Gao, Masayoshi Tanaka, Zhen Zhang, Yanru Huang, Takahiko Mitsui, Manabu Kamiyama, Schuichi Koizumi, Jianglin Fan, Masayuki Takeda, Jian Yao
Carbenoxolone (CBX) is a clinically prescribed drug for the treatment of digestive ulcer and inflammation. It is also a widely used pharmacological inhibitor of several channels in basic research. Given that the overactivity of several channels, including those inhibitable by CBX, underlies bladder dysfunction, we tested the potential therapeutic application and mechanism of CBX in the treatment of voiding dysfunction. In a mouse model of cystitis induced by cyclophosphamide (CYP), CBX administration prevented the CYP-elicited increase in bladder weight, oedema, haemorrhage, and urothelial injury...
February 28, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28244210/clinical-characteristics-and-outcome-of-patients-with-situational-syncope-compared-to-patients-with-vasovagal-syncope
#14
Kevin E Wenzke, Kathleen E Walsh, Matthew Kalscheur, Stephen Wasmund, Richard L Page, Michele Brignole, Mohamed H Hamdan
BACKGROUNDS: The purpose of the study was to assess the clinical outcome of patients with situational syncope (SS) compared to patients with vasovagal syncope (VVS). METHODS: We assessed the prevalence, patients' characteristics and outcome of consecutive patients with SS and VVS who presented to the Faint and Fall Clinic (University of Wisconsin) between January 2013 and December 2015. RESULTS: SS was found in 55/1401(4.0%) syncope patients with follow-up data available in 47 patients: defecation (n = 16), micturition (n = 15), cough (n = 10), swallow (n = 3), laughter (n = 1), sneeze (n = 1) and cough plus laughter (n = 1)...
February 28, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28244147/a-genetic-female-mouse-model-with-congenital-genitourinary-anomalies-and-adult-stages-of-urinary-incontinence
#15
Pedram Akbari, Ali Fathollahi, Rong Mo, Michael Kavran, Nicole Episalla, Chi-Chung Hui, Walid A Farhat, Adonis K Hijaz
AIMS: To characterize the urinary incontinence observed in adult Gli2(+/)(-) ; Gli3(Δ699/+) female mice and identify the defects underlying the condition. METHODS: Gli2(+/)(-) and Gli3(Δ699/+) mice were crossed to generate: wild-type, mutant Gli2 (Gli2(+/-) ), mutant Gli3 (Gli3(Δ699/+) ), and double mutant (Gli2(+/-) ; Gli3(Δ699/+) ) female mice, verified via Polymerase Chain Reactions. Bladder functional studies including cystometrogram (CMG), leak point pressure (LPP), and voiding testing were performed on adult female mice...
February 28, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28242819/a-rat-long-lasting-cystitis-model-induced-by-intravesical-injection-of-hydrogen-peroxide
#16
Koji Dogishi, Ken Okamoto, Tsuyoshi Majima, Shizuka Konishi-Shiotsu, Takashi Homan, Mizuki Kodera, Shohei Oyama, Tatsuya Oyama, Hisashi Shirakawa, Naoki Yoshimura, Takayuki Nakagawa, Shuji Kaneko
Novel longer lasting inflammatory bladder animal models are needed to better understand the pathophysiology of chronic cystitis. We previously developed a relatively long-lasting mouse cystitis model by intravesical injection of hydrogen peroxide (H2O2). To further evaluate its pathophysiology, in this study, we established and analyzed a rat cystitis model. Under anesthesia, 1.5% H2O2 solution was introduced transurethrally into the bladder of female rats, and kept for 30 min. The H2O2 injection significantly increased the number of micturition events up to day 14 and decreased urine volume per micturition, with the smallest volumes on day 3, compared with the vehicle-treated group...
February 2017: Physiological Reports
https://www.readbyqxmd.com/read/28237777/integrin-linked-kinase-improves-functional-recovery-of-diabetic-cystopathy-and-mesenchymal-stem-cell-survival-and-engraftment-in-rats
#17
Yi Huang, Liucheng Ding, Yunpeng Shao, Zhengsen Chen, Baixin Shen, Yinchao Ma, Lijie Zhu, Zhongqing Wei
OBJECTIVES: Diabetic cystopathy (DCP), characterized by peripheral neuropathy-associated bladder dysfunction, is a common urinary complication in patients with diabetes (~80%). Bone marrow mesenchymal stem cell (BMMSC) transplantation, a new and emerging regenerative therapy, provides a curative option for DCP. However, the application of this therapy is limited by the low survival rate and engraftment of transplanted stem cells. This study was undertaken to determine whether integrin-linked kinase (ILK) overexpression would improve stem cell survival and engraftment after BMMSC transplantation...
February 22, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28220521/indirect-treatment-comparison-itc-of-medical-therapies-for-an-overactive-bladder
#18
Aneta Obloza, Joshua Kirby, Derrick Yates, Philip Toozs-Hobson
BACKGROUND: Overactive bladder syndrome (OAB) is a chronic and prevalent condition which has a negative impact on Quality of Life. The National Institute of Clinical Excellence issued two documents which give slightly varying algorithms of pharmacotherapy for OAB, offering mirabegron as a possible treatment in certain circumstances. In the absence of trials involving a direct comparison of therapies, an indirect comparison can provide useful information on the difference in treatment effects between competing interventions...
February 21, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28220212/rho-kinase-inhibition-ameliorates-cyclophosphamide-induced-cystitis-in-rats
#19
Andrzej Wróbel, Urszula Doboszewska, Ewa Rechberger, Karol Rojek, Anna Serefko, Ewa Poleszak, Krystyna Skalicka-Woźniak, Jarosław Dudka, Piotr Wlaź
Hemorrhagic cystitis often develops in patients treated with cyclophosphamide (CYP). Studies have indicated that Rho kinase (ROCK) inhibitors may suppress detrusor overactivity symptoms and possess anti-inflammatory properties. The aim of the present study was to investigate whether inhibition of ROCK reduces cystometric and histopathological changes associated with CYP-induced cystitis. The rats received GSK 269962, a ROCK inhibitor, at a dose of 30 mg/kg daily, or vehicle for 7 days. Then, acute chemical cystitis leading to bladder overactivity was induced by CYP injection (200 mg/kg i...
February 21, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28217761/modeling-of-chronic-radiation-induced-cystitis-in-mice
#20
Bernadette M M Zwaans, Sarah Krueger, Sarah N Bartolone, Michael B Chancellor, Brian Marples, Laura E Lamb
PURPOSE: Radiation cystitis (RC), a severe inflammatory bladder condition, develops as a side-effect of pelvic radiation therapy in cancer patients. There are currently no effective therapies to treat RC, in part due to the lack of preclinical model systems. In this study, we developed a mouse model for RC and used a small animal radiation research platform (SARRP) to simulate the targeted delivery of radiation as used with human patients. METHODS AND MATERIALS: To induce RC, C3H mice received a single radiation dose of 20Gy delivered through two beams...
October 2016: Advances in Radiation Oncology
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