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https://www.readbyqxmd.com/read/29149420/blood-clearance-and-occupational-exposure-for-177-lu-dotatate-compared-to-177-lu-psma-radionuclide-therapy
#1
Mohammad Abuqbeitah, Mustafa Demir, Lebriz Uslu-Beşli, Nami Yeyin, Kerim Sönmezoğlu
The main target of this work is to examine blood clearance and external exposure for (177)Lu-DOTATATE compared with new emerging (177)Lu-PSMA therapy. Blood clearance and radiation exposure of 31 patients treated with 5.5 ± 1.1 GBq (177)Lu-DOTATATE were compared to those of 23 patients treated with 7.4 GBq (177)Lu-PSMA. Dose rates were measured at several distances and time points up to 120 h after treatment. Blood samples were collected conjunctively after infusion. Caregiver's cumulative dose was measured by means of an OSL (optically stimulated luminescence) dosimeter for 4-5 days and medical staff's dose was also estimated using electronic personal dosimeters...
November 17, 2017: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/29146295/new-markers-for-early-detection-of-acute-kidney-injury-after-transcatheter-aortic-valve-implantation
#2
Cedrick Zaouter, Frédérique Priem, Lionel Leroux, Guillaume Bonnet, Marie-Lise Bats, Marie Christine Beauvieux, Alain Rémy, Alexandre Ouattara
BACKGROUND: Acute Kidney Injury (AKI) is a frequent complication after a Transcatheter Aortic Valve Implantation (TAVI). Biomarkers such as urinary G1 cell cycle arrest proteins (TIMP-2 and IGFBP7) and sonographic evaluation (Doppler Renal Resistive Index (RRI)) have been advocated to predict AKI at an early stage after a TAVI-procedure. The primary aim was to determine the predictive value of these markers to detect AKI after a TAVI-procedure at an early phase. PATIENTS AND METHODS: In a prospective observational study, 62 consecutive patients were scheduled for a TAVI...
November 13, 2017: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29140559/comparative-efficacy-and-tolerability-of-solifenacin-5%C3%A2-mg-day-versus-other-oral-antimuscarinic-agents-in-overactive-bladder-a-systematic-literature-review-and-network-meta-analysis
#3
Jameel Nazir, Con Kelleher, Samuel Aballéa, Khaled Maman, Zalmai Hakimi, Colette Mankowski, Isaac Odeyemi
AIMS: To compare efficacy and tolerability of solifenacin 5 mg/day versus other oral antimuscarinic agents for the treatment of overactive bladder (OAB). METHODS: Literature searches of MEDLINE, Embase, and the Cochrane Library were undertaken to identify randomized controlled trials in OAB (2000-2015) for antimuscarinic agents. A network meta-analysis (NMA) was performed to estimate efficacy and tolerability outcomes for solifenacin 5 mg/day relative to other antimuscarinics...
November 15, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29135903/micturition-syncope-in-childhood-how-to-recognize-and-manage-it
#4
Pierluigi Marzuillo, Stefano Guarino, Vincenzo Tipo, Andrea Apicella, Anna Grandone, Mario Diplomatico, Cesare Polito, Emanuele Miraglia Del Giudice, Angela La Manna, Laura Perrone
Frequently, general pediatricians could face a patient with syncope, which represents approximately 1% to 3% of emergency visits. Micturition syncope is a transient loss of consciousness with onset immediately before, during, or after micturition. Literature evidence indicates that healthy young men are a population with major risk for presenting micturition syncope, with a peak of incidence around 40 to 50 years of age. Usually, this syncope occurs in the morning, after wake-up, or, more generally, when the male patients assume the orthostatic position after a period of supine position in a warm bed...
November 14, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29133002/clinical-characteristics-of-lumbosacral-spinal-dural-arteriovenous-fistula-davf-comparison-to-thoracic-davf
#5
Toshiki Endo, Takumi Kajitani, Tomoo Inoue, Kenichi Sato, Kuniyasu Niizuma, Hidenori Endo, Yasushi Matsumoto, Teiji Tominaga
OBJECTIVE: Spinal dural arteriovenous fistula (DAVF) occurs at any spinal level but the clinical characteristics of lumbosacral DAVF have not been well documented. Purpose of this study was to evaluate clinical characteristics of lumbosacral DAVF and compare these features to those in thoracic DAVF. METHODS: Twenty-five consecutive patients with 16 thoracic and 9 lumbosacral DAVF were included (mean age, 63.9 years; twenty men). All patients presented with progressive myelopathy...
November 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29132243/protective-effects-of-estradiol-and-dihydrotestosterone-following-spinal-cord-injury
#6
Dale R Sengelaub, Qi Han, Nai-Kui Liu, Melissa Maczuga, Violetta Szalavari, Stephanie Valencia, Xiao-Ming Xu
Spinal cord injury (SCI) results in lesions that destroy tissue and disrupt spinal tracts, producing deficits in locomotor and autonomic function. We previously demonstrated that motoneurons, and the muscles they innervate, show pronounced atrophy after SCI, and these changes are prevented by treatment with testosterone. Here we assessed if the testosterone active metabolites, estradiol and dihydrotestosterone, have similar protective effects after SCI. Young adult female rats received either sham or T9 spinal cord contusion injuries and were treated with estradiol, dihydrotestosterone, both, or nothing via Silastic capsules...
November 13, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29124503/urological-dysfunction-in-synucleinopathies-epidemiology-pathophysiology-and-management
#7
REVIEW
Ryuji Sakakibara, Fuyuki Tateno, Tatsuya Yamamoto, Tomoyuki Uchiyama, Tomonori Yamanishi
OBJECTIVE: Parkinson's disease (PD) and multiple system atrophy (MSA) are major neurogenerative diseases characterized pathologically by abnormal alpha-synuclein aggregation. PD and MSA are clinically characterized by motor disorder and bladder dysfunction (mainly urinary urgency and frequency, also called overactive bladder). However, few literatures are available concerning bladder dysfunction in PD or MSA. METHOD: A systematic review. RESULTS: The bladder dysfunction in MSA is more severe than that in PD for large post-void residual or urinary retention...
November 9, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/29123489/plasmapheresis-responsive-rapid-onset-dementia-with-predominantly-frontal-dysfunction-in-the-context-of-hashimoto-s-encephalopathy
#8
Dominique Endres, Magnus S Vry, Petra Dykierek, Anne N Riering, Eva Lüngen, Oliver Stich, Rick Dersch, Nils Venhoff, Daniel Erny, Irina Mader, Philipp T Meyer, Ludger Tebartz van Elst
Background: Hashimoto's encephalopathy (HE) is a rare immunological neuropsychiatric disorder characterized by increased antithyroid antibodies and mixed neurological and psychiatric symptoms. HE has been previously discussed as a differential diagnosis for rapid progressive dementia. However, most of these patients suffered from additional neurological symptoms, like ataxia or seizures. Case presentation: Here, we present the case of a 59-year-old female patient suffering rapid onset dementia with salient frontal executive dysfunction...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29121450/urethral-afferent-signalling-role-of-5-ht-paraneurons
#9
EDITORIAL
K-E Andersson
In this issue of Acta Physiologica, Kullmann et al. examined the morphology and potential role in sensory signaling of a different class of specialized cells in mouse urethral epithelium that express serotonin (5-HT), termed paraneurons.(1) They propose that the paraneurons function as important detectors and transmitters in the urethral sensory mechanisms. Signalling from the afferent nerves of the lower urinary tract (LUT) is required for sensation of pain, bladder filling, and initiation and maintenance of the micturition reflex...
November 9, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/29116440/parenchymal-neuro-beh%C3%A3-et-disease-with-erectile-dysfunction-and-micturition-disturbances-case-report-and-literature-review
#10
REVIEW
Ali Taylan, Merih Birlik
Parenchymal neuro-Behçet disease (NBD) is a serious clinic condition with a sub-acute or chronic disease course that results in incapability through pyramidal tract involvement. Though well-known consequences can deter a patient's life, both urinary symptoms and sexual dysfunction are underestimated complications of NBD and closely related in timing. Here, we report the case of a young male patient with parenchymal NBD who developed urinary incontinence and erectile dysfunction in addition to widespread pyramidal tract signs and symptoms...
November 7, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29100756/trpv1-alterations-in-urinary-bladder-dysfunction-in-a-rat-model-of-stz-induced-diabetes
#11
Bizhan R Sharopov, Kseniya L Gulak, Igor B Philyppov, Anna V Sotkis, Yaroslav M Shuba
AIMS: More than half of diabetic patients experience voiding disorder termed diabetic urinary bladder dysfunction (DBD). Here we have investigated how the alterations in transient receptor potential vanilloid 1 (TRPV1) ion channel expressed in bladder-innervating afferents may contribute to DBD pathogenesis. MAIN METHODS: The rat model of streptozotocin (STZ)-induced diabetes was used. The functional profile of TRPV1 in retrogradely labeled afferent, bladder-innervating dorsal root ganglia (DRG) neurons was examined using patch clamp...
October 31, 2017: Life Sciences
https://www.readbyqxmd.com/read/29099378/-prognostic-factors-predicting-failure-of-the-trial-without-catheter-after-tamsulosin-in-patients-with-acute-urinary-retention
#12
Oscar Luis Farelo-Trejos, Nahuel Eduardo Paesano, Juan José Serna-Hurtado, Mauro Fabián García, Juan Ignacio Monzó-Gardiner
OBJECTIVE: To analyze prognostic variables that impact on the trial without catheter after tamsulosin in patients with acute urine retention. METHODS: Retrospective analysis of a prospective database of a cohort of successive patients with acute urinary retention due to benign prostatic hyperplasia attended at the urology emergency room during one year time period. We analyzed the clinical and radiological characteristics and the international prostatic symptom score questionnaire of a total 65 male patients...
November 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29098198/minimally-invasive-repair-of-a-prostatorectal-fistula-with-an-over-the-scope-rectal-clip
#13
Burkhard Ubrig, Ekkehard Schmidt-Heikenfeld, Stephan Degener, Alexander Roosen, Anselm Boy
Background: Fistulae between the prostatic urethra and the rectum are rare. They may result from prostatic or rectal surgery. Predisposing factors are previous radiation or immunosuppression. The repair of such fistulae usually involves major surgery. Recently, clips that can be deployed over an endoscope have been developed to close gastrointestinal fistulae or access points for natural orifice surgery. We report the first case of effective treatment of a prostatorectal fistula with a rectal "over-the-scope" clip...
2017: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/29096218/feasibility-of-deep-brain-stimulation-for-controlling-the-lower-urinary-tract-functions-an-animal-study
#14
Shih-Ching Chen, Pei-Yi Chu, Tsung-Hsun Hsieh, Yu-Ting Li, Chih-Wei Peng
OBJECTIVE: To evaluate the feasibility of deep brain stimulation (DBS) and compare the potential of four DBS targets in rats for regulating bladder activity: the periaqueductal gray (PAG), locus coeruleus (LC), rostral pontine reticular nucleus (PnO), and pedunculopontine tegmental nucleus (PPTg). METHODS: A bipolar stimulating electrode was implanted. The effects of DBS on the inhibition and activation of micturition reflexes were investigated by using isovolumetric intravesical pressure recordings...
September 30, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29090653/tuberculous-pyelonephritis-in-children-three-case-reports
#15
Nimisha Arora, Abhijeet Saha, Manpreet Kaur
Tuberculous pyelonephritis is rare in children; three case reports are presented. Case 1 was an 11-year-old girl with a previous history of pulmonary tuberculosis who presented with flank pain and fever for 10 days. An ultrasound suggested focal pyelonephritis, and a contrast-enhanced computed tomography (CECT) scan demonstrated acute focal pyelonephritis and a perinephric collection. Mycobacterium tuberculosis was cultured in the urine. She responded well to anti-tuberculous treatment (ATT). Case 2 was a 13-year-old boy who presented with fever, haematuria, burning micturition, proteinuria (3+) and cervical lymphadenopathy...
November 1, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/29073343/prevalence-and-disease-specific-risk-factors-for-lower-urinary-tract-symptoms-in-systemic-sclerosis-an-international-multi-centric-study
#16
Gregor John, Jérôme Avouac, Silvia Piantoni, Pamela Polito, Micaela Fredi, Franco Cozzi, Paolo Airo, Marie-Elise Truchetet, Franco Franceschini, Yannick Allanore, Carlo Chizzolini
OBJECTIVE: The aim of the present study was to determine the prevalence of lower urinary tract symptoms (LUTS) in systemic sclerosis (SSc), to find specific risk factors and to assess their impact on quality of life (QoL). METHODS: In a multi-centric study, 334 patients completed a self-administered questionnaire on LUTS and QoL. LUTS were classified into three main categories: storage, voiding, and post micturition symptoms. Digestive symptoms burden was captured by a visual analogic scale, divided into five equal categories...
October 26, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29071160/diagnosis-and-treatment-of-urethral-prolapse-in-children-16%C3%A2-years-experience-with-89-chinese-girls
#17
Yi Wei, Sheng-de Wu, Tao Lin, Da-Wei He, Xu-Liang Li, Guang-Hui Wei
OBJECTIVE: To review our experience and results in the diagnosis and treatment of urethral prolapse (UP) in Chinese girls. PATIENTS AND METHODS: We conducted a retrospective chart review of 89 consecutive girls (aged <16 years) with UP and without other complications, who received treatment for UP from January 1999 to January 2015 (a study period of 16 years) at the Children's Hospital of Chongqing Medical University, China. Data analysed included: age, symptoms, clinical findings, predisposing factors, management, and outcomes...
September 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/29071159/mathieu-technique-with-incision-of-the-urethral-plate-versus-standard-tubularised-incised-plate-urethroplasty-in-primary-repair-of-distal-hypospadias-a-prospective-randomised-study
#18
Mostafa Khalil, Tarek Gharib, Waleed El-Shaer, Ahmed Sebaey, Basheer Elmohamady, Khalid Elgamal
OBJECTIVE: To compare outcomes of the Mathieu incised-plate (Mathieu-IP) technique vs the standard tubularised incised-plate (TIP) technique for primary management of distal hypospadias. PATIENTS AND METHODS: Between April 2012 and August 2015, 66 patients (aged 15-60 months) with primary distal hypospadias were randomly allocated to two groups. Group 1 included 34 patients who underwent Mathieu-IP repair and Group 2 included 32 patients managed using the TIP technique for primary management of distal hypospadias...
September 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/29070575/saphenous-nerve-stimulation-normalizes-bladder-underactivity-induced-by-tibial-nerve-stimulation-in-cats
#19
Shun Li, Xing Li, Katherine Theisen, Jeffrey Browning, Bing Shen, Jicheng Wang, James R Roppolo, William C de Groat, Changfeng Tai
This study in α-chloralose anesthetized cats aimed at investigating the bladder responses to saphenous nerve stimulation (SNS). A urethral catheter was used to infuse the bladder with saline and to record changes in bladder pressure. With the bladder fully distended, SNS at 1 Hz frequency and an intensity slightly below the threshold (T) for inducing an observable motor response of the hindlimb muscles induced large amplitude (40-150 cmH2O) bladder contractions. Application of SNS (1 Hz, 2-4T) during cystometrograms (CMGs), when the bladder was slowly (1-3 ml/min) infused with saline, significantly (p<0...
October 25, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29064654/an-unusual-presentation-of-urethral-duplication-presenting-with-chronic-bladder-retention-left-scrotal-transposition-and-left-renal-agenesis
#20
Antonio Macedo, Marcela Leal da Cruz, João Luiz Gomes Parizi, Gustavo Marconi Caetano Martins, Riberto Liguori, Sérgio Leite Ottoni, Bruno Leslie, Gilmar Garrone
INTRODUCTION AND OBJECTIVE: Urethral duplication is a rare congenital anomaly, with roughly 200 cases reported in the literature (1). It is more frequent in males, with few cases reported in females. The clinical presentation differs according to the anatomical variant present. The duplication most commonly occurs in the sagittal plane with one urethra located ventrally and the other dorsally (2). Usually the ventral urethra is the more functional of both. Duplications occurring in the coronal plane are quite rare and they are usually associated with bladder duplication (3)...
October 24, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
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