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Micturition

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https://www.readbyqxmd.com/read/28435033/could-reduced-fluid-intake-cause-the-placebo-effect-seen-in-overactive-bladder-clinical-trials-analysis-of-a-large-solifenacin-integrated-database
#1
Sender Herschorn, Christopher R Chapple, Robert Snijder, Emad Siddiqui, Linda Cardozo
OBJECTIVE To assess the hypothesis that patients receiving placebo in overactive bladder (OAB) trials who experience less benefit from 'treatment' continue with behavioral modifications such as fluid restriction, whereas those on active treatment adopt more normal drinking patterns. This may manifest itself as a reduction in micturition frequency (MF). MATERIALS AND METHODS We interrogated a large integrated database containing pooled patient data from 4 randomized, placebo-controlled phase III OAB solifenacin studies...
April 20, 2017: Urology
https://www.readbyqxmd.com/read/28425078/involvement-of-interstitial-cells-of-cajal-in-bladder-dysfunction-in-mice-with-experimental-autoimmune-encephalomyelitis
#2
Zhibo Jin, Yinghui Ding, Rui Xue, Zhankui Jia, Zhenlin Huang, Yafei Ding, Chaohui Gu, Jinjian Yang
BACKGROUND: Bladder dysfunction is an important symptom of experimental autoimmune encephalomyelitis (EAE). Our previous study showed that EAE-induced upregulation of the E-prostanoid receptor 3 (EP3) and E-prostanoid receptor 4 (EP4) in the bladder was accompanied by bladder dysfunction. Although many other studies have evaluated the lower urinary tract symptoms in multiple sclerosis, the mechanism remains unclear. OBJECTIVES: To investigate the effects of interstitial cells of Cajal (ICC) on bladder dysfunction in a novel neurogenic bladder model induced by experimental autoimmune encephalomyelitis...
April 19, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28423044/the-long-term-outcome-of-micturition-defecation-and-sexual-function-after-spinal-surgery-for-cauda-equina-syndrome
#3
Nina S Korse, Anna B Veldman, Wilco C Peul, Carmen L A Vleggeert-Lankamp
BACKGROUND: Cauda equina syndrome (CES) is a rare neurologic complication of lumbar herniated disc for which emergency surgical decompression should be undertaken. Despite the common belief that the restoration of functions that are affected by CES can take several years postoperatively, follow up seldom exceeds the first year after surgery. Long term outcome of especially micturition, defecation and sexual function-which are by definition affected in CES-are unknown. The aim of this study is to evaluate 1) postoperative long term outcome of micturition, defecation and sexual function in CES patients 2) attitude of patients towards received hospital care with regard to (recovery of) these functions...
2017: PloS One
https://www.readbyqxmd.com/read/28421392/combination-of-sacral-nerve-and-tibial-nerve-stimulation-for-treatment-of-bladder-overactivity-in-pigs
#4
Xing Li, Limin Liao, Guoqing Chen, Zhaoxia Wang, Han Deng
PURPOSE: Sacral nerve and tibial nerve stimulation have been singly used to treat overactive bladder (OAB). This study evaluated the effects of both combined stimulation on treating bladder overactivity in pigs and explored a novel treatment modality for OAB. METHODS: An implant-driven stimulator of the S3 spinal nerve was implanted in 5 pigs. The contralateral tibial nerve was stimulated by an external stimulator. Multiple cystometrograms were performed to determine the effects of single nerve stimulation and combination sacral nerve stimulation (SNS) and tibial nerve stimulation (TNS) on the micturition reflex by infusing normal saline (NS) or acetic acid (AA)...
April 18, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28415952/effective-treatment-of-ketamine-associated-cystitis-with-botulinum-toxin-type-a-injection-combined-with-bladder-hydrodistention
#5
Jianfeng Zeng, Haibiao Lai, Dongxiang Zheng, Liang Zhong, Zhifeng Huang, Shanyun Wang, Weiwei Zou, Lianbo Wei
Objective Ketamine-associated cystitis (KAC) has been described in a few case reports, but its treatment in a relatively large number of patients has not been documented. This study aimed to describe our experience of treatment of 36 patients with KAC. Methods Thirty-six patients (30 males and 6 females, aged 19-38 years) with KAC, who had previously taken a muscarinic receptor blocker and/or antibiotics, but without symptomatic relief, were treated with botulinum toxin A injection combined with bladder hydrodistention...
April 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28407338/tolterodine-er-reduced-increased-bladder-wall-thickness-in-women-with-overactive-bladder-a-randomized-placebo-controlled-double-blind-parallel-group-study
#6
Rhiannon Bray, Rufus Cartwright, Linda Cardozo, Simon Hill, Zhonghong Guan, Vik Khullar
AIMS: We evaluated the effect of Tolterodine extended release (TER) versus placebo on bladder wall thickness (BWT) using transvaginal ultrasound in women with overactive bladder (OAB). MATERIALS AND METHODS: We recruited 79 women with symptoms of OAB with a mean age of 47 years who had a BWT of at least 5 mm and a post-micturition volume of less than 50 mL at screening. Subjects received TER 4 mg or placebo once daily for the first 12 weeks of the study. For the subsequent 12 weeks, all subjects received TER 4 mg once daily...
April 13, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28405763/five-year-outcomes-of-thulium-vapoenucleation-of-the-prostate-for-symptomatic-benign-prostatic-obstruction
#7
A J Gross, A K Orywal, B Becker, C Netsch
INTRODUCTION AND OBJECTIVES: To assess the 5-year outcomes of thulium vapoenucleation of the prostate (ThuVEP) in patients with benign prostatic obstruction (BPO) retrospectively. METHODS: Five-hundred patients were treated with ThuVEP between January 2007 and January 2010 at our institution. Patients were reassessed 1 and 5-years after ThuVEP with International Prostate Symptom Score (IPSS), Quality of Life (QoL), urinary peak flow (Qmax), postvoid residual volume (PVR), PSA and prostate volume...
April 12, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28403591/comparison-of-the-clinical-parameters-of-benign-prostate-hyperplasia-in-diabetic-and-non-diabetic-patients
#8
Levent Ozcan, Huseyin Besiroglu, Murat Dursun, Emre Can Polat, Alper Otunctemur, Emin Ozbek
OBJECTIVE: We evaluated the correlation between benign prostate hyperplasia (BPH) measures and diabetes mellitus in men with benign prostate hyperplasia in a prospective study. MATERIALS AND METHODS: Between 2008-2012, 100 diabetic and 200 non diabetic patients undergoing surgery due to benign prostate hyperplasia were enrolled in the study. The parameters evaluated for each patients included prostate volume, fasting blood glucose, HbA1c, total testosterone, total prostatic specific antigen (T-PSA), triglicerides, total cholesterol and body mass index (BMI)...
March 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28396595/p2y6-deficiency-increases-micturition-frequency-and-attenuates-sustained-contractility-of-the-urinary-bladder-in-mice
#9
Satoru Kira, Mitsuharu Yoshiyama, Sachiko Tsuchiya, Eiji Shigetomi, Tatsuya Miyamoto, Hiroshi Nakagomi, Keisuke Shibata, Tsutomu Mochizuki, Masayuki Takeda, Schuichi Koizumi
The role of the P2Y6 receptor in bladder function has recently attracted a great deal of attention in lower urinary tract research. We conducted this study to determine contributions of the P2Y6 receptor in lower urinary tract function of normal phenotypes by comparing P2Y6-deficient mice and wild-type mice. In in vivo experiments, P2Y6-deficient mice had more frequent micturition with smaller bladder capacity compared to wild-type mice; however, there was no difference between these groups in bladder-filling pressure/volume relationships during cystometry under decerebrate, unanaesthetized conditions...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28386345/tgf-%C3%AE-mapk-signaling-mediates-the-effects-of-bone-marrow-mesenchymal-stem-cells-on-urinary-control-and-interstitial-cystitis-after-urinary-bladder-transplantation
#10
Ya Xiao, Ya-Jun Song, Bo Song, Chi-Bing Huang, Qing Ling, Xiao Yu
OBJECTIVE: This study aimed to explore the role of the transforming growth factor-β/mitogen activated protein kinase (TGF-β/MAPK) signaling pathway in the effects of bone marrow mesenchymal stem cells (BMSCs) on urinary control and interstitial cystitis in a rat model of urinary bladder transplantation. METHODS: A urinary bladder transplantation model was established using Sprague-Dawley rats. Rats were assigned to normal (blank control), negative control (phosphate-buffered saline injection), BMSCs (BMSC injection), sp600125 (MAPK inhibitor injection), or protamine sulfate (protamine sulfate injection) groups...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28363231/-management-of-adverse-effects-of-opioid-therapy
#11
Stefan Wirz
More than 6 million people in Germany suffer from chronic pain which greatly impairs their wellbeing. Often the only therapeutic option is to use class 2 or 3 analgesic opioids in the WHO classification, as class 1 analgesics may be toxic or of limited efficacy. However, the high incidence of opioid side effects leads to high discontinuation rates. Thus, the success of opioid treatment is also highly dependent on the management of the safety and tolerability of the treatment. Most opioid side effects, such as nausea and sedation, predominantly occur in the initial phase of therapy...
April 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28361203/physiotherapy-and-behavior-therapy-for-the-treatment-of-overactive-bladder-syndrome-a-prospective-cohort-study
#12
Martina Wolz-Beck, Christl Reisenauer, Giselle E Kolenic, Sabine Hahn, Sara Y Brucker, Markus Huebner
PURPOSE: To determine the efficacy of physiotherapy and behavior therapy and to find specific subgroups of women with overactive bladder syndrome that might gain increased benefit from this therapy. METHODS: Women with ≥10 micturitions per 24-h period were included. Six to nine therapy sessions were held within a 14-day interval. Efficacy end point was a reduction in micturitions and in episodes of nocturia. Secondary outcomes included ICIQ-OAB, ICIQ-OABqol and visual analog scales...
March 30, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28358321/the-influence-of-tetrodotoxin-ttx-on-the-distribution-and-chemical-coding-of-caudal-mesenteric-ganglion-camg-neurons-supplying-the-porcine-urinary-bladder
#13
Ewa Lepiarczyk, Agnieszka Bossowska, Jerzy Kaleczyc, Marta Majewska, Sławomir Gonkowski, Mariusz Majewski
The treatment of micturition disorders creates a serious problem for urologists. Recently, new therapeutic agents, such as neurotoxins, are being considered for the therapy of urological patients. The present study investigated the chemical coding of caudal mesenteric ganglion (CaMG) neurons supplying the porcine urinary bladder after intravesical instillation of tetrodotoxin (TTX). The CaMG neurons were visualized with retrograde tracer Fast blue (FB) and their chemical profile was disclosed with double-labeling immunohistochemistry using antibodies against tyrosine hydroxylase (TH), neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), somatostatin (SOM), calbindin (CB), galanin (GAL) and neuronal nitric oxide synthase (nNOS)...
March 30, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28353601/urethral-hemangioma-in-a-prepubertal-female-patient-report-of-a-rare-case
#14
Chiao-Ching Li, Chiao-Zhu Li, Ching-Heng Yen, Wen-Chuan Tsai, Sheng-Tang Wu, Tai-Lung Cha, En Meng
RATIONALE: Urethral hemangiomas commonly occur in men or elderly women. We presented a rare case of urethral hemangioma in a prepubertal female patient. PATIENTS CONCERNS: An 8-year-old girl had the complaints of bloody staining of clothing, a foul perineal odor, and urethral pain. She was brought to our genitourinary outpatient department for survey and a single, 1-cm compressible reddish nodule at the 10-2 o'clock position in the distal urethra was found. DIAGNOSES: Urethral hemangioma in a prepubertal girl was diagnosed after excision of the urethral nodule...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28346718/modulation-of-the-rat-micturition-reflex-with-transcutaneous-ultrasound
#15
Daniel P Casella, Anne G Dudley, Douglass B Clayton, John C Pope, Stacy T Tanaka, John Thomas, Mark C Adams, John W Brock, Charles F Caskey
INTRODUCTION: Low intensity focused ultrasound has recently been identified as a novel method of stimulating targeted neurons. We hypothesized that ultrasound stimulation of the posterior tibial nerve would inhibit bladder contractions in an established rat model of rhythmic bladder contractions. METHODS: Cyclical detrusor contractions were initiated by placing a transurethral catheter in female rats and infusing saline into the bladder. Transcutaneous ultrasound pulses were then delivered to the lower extremity of a rat (overlying the posterior tibial nerve) using a single element spherically focused 250 kHz transducer...
March 27, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28346712/comparison-of-three-methods-to-analyze-detrusor-contraction-during-micturition-in-men-over-50-years-of-age
#16
Celine Ten Donkelaar S, Peter Rosier, Laetitia de Kort
AIMS: To grade detrusor voiding contraction three parameters are used: the Schäfer pressure-flow nomogram (LinPURR), the bladder contractility index (BCI) and the maximum Watt factor (Wmax ). Because these methods to quantify detrusor contraction and/or to diagnose detrusor underactivity (DU) have not yet been mutually compared, this study compares these three methods of grading detrusor contraction. MATERIALS AND METHODS: Evaluated were 1420 urodynamic pressure-flow studies from 1222 men (aged >50 years) with lower urinary tract symptoms (LUTS)...
March 27, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28340519/barrington-s-nucleus-neuroanatomic-landscape-of-the-mouse-pontine-micturition-center
#17
Anne M J Verstegen, Veronique Vanderhorst, Paul A Gray, Mark L Zeidel, Joel C Geerling
Barrington's nucleus (Bar) is thought to contain neurons that trigger voiding and thereby function as the "pontine micturition center." Lacking detailed information on this region in mice, we examined gene and protein markers to characterize Bar and the neurons surrounding it. Like rats and cats, mice have an ovoid core of medium-sized Bar neurons located medial to the locus coeruleus (LC). Bar neurons express a GFP reporter for Vglut2, develop from a Math1/Atoh1 lineage, and exhibit immunoreactivity for NeuN...
March 24, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28322961/galactoglucomannan-rich-hemicellulose-extract-from-norway-spruce-picea-abies-exerts-beneficial-effects-on-chronic-prostatic-inflammation-and-lower-urinary-tract-symptoms-in-vivo
#18
Yvonne Konkol, Heikki Vuorikoski, Johanna Tuomela, Bjarne Holmbom, Jenni Bernoulli
Galactoglucomannan (GGM) is the main hemicellulose class in wood of coniferous trees and could be potentially utilized as a possible health-promoting substance for food and pharmaceutical industry. Our aim was to evaluate effects of orally administered GGM-rich extract from Norway spruce in a rat model of chronic prostatitis associated with lower urinary tract symptoms (LUTS). Prostatic inflammation and LUTS was induced in male rats using testosterone and 17β-estradiol exposure for 18 weeks. Rats were treated with 2% GGM dissolved in drinking water during weeks 13-18...
March 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28302238/gitelman-syndrome
#19
Qurat Ul Ain Mustafa, Zujaja Hina Haroon, Aamir Ijaz, Muhammad Tanveer Sajid, Muhammad Ayyub
Gitelman syndrome (GS) is the most frequently inherited renal salt-wasting tubulointerstitial disease. It follows variable but usually asymptomatic benign course. We present a rare case of GS that remained clinical enigma. A 22-year male presented with severe episodic fatigue involving all limbs associated with episodes of sinking, palpitations, salt craving, increased thirst and frequent micturition hampering his routine daily activities. Laboratory workup revealed serum potassium, 2.7 mmol/L, serum magnesium, 0...
March 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28293500/a-systematic-review-of-metoidioplasty-and-radial-forearm-flap-phalloplasty-in-female-to-male-transgender-genital-reconstruction-is-the-ideal-neophallus-an-achievable-goal
#20
Jordan D Frey, Grace Poudrier, Michael V Chiodo, Alexes Hazen
INTRODUCTION: The complex anatomy and function of the native penis is difficult to surgically replicate. Metoidioplasty and radial forearm flap phalloplasty (RFFP) are the 2 most commonly utilized procedures for transgender neophallus construction. METHODS: A MEDLINE search for metoidioplasty and RFFP in female-to-male genital reconstruction was performed. Primary outcome measures were subsequently compared. A systematic review was planned in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyse guidelines...
December 2016: Plastic and Reconstructive Surgery. Global Open
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