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https://www.readbyqxmd.com/read/29656592/the-applicability-of-furfuryl-gelatin-as-a-novel-bioink-for-tissue-engineering-applications
#1
Shweta AnilKumar, Shane C Allen, Nishat Tasnim, Tahmina Akter, Shinhye Park, Alok Kumar, Munmun Chattopadhyay, Yoshihiro Ito, Laura J Suggs, Binata Joddar
Three-dimensional bioprinting is an innovative technique in tissue engineering, to create layer-by-layer structures, required for mimicking body tissues. However, synthetic bioinks do not generally possess high printability and biocompatibility at the same time. So, there is an urgent need for naturally derived bioinks that can exhibit such optimized properties. We used furfuryl-gelatin as a novel, visible-light crosslinkable bioink for fabricating cell-laden structures with high viability. Hyaluronic acid was added as a viscosity enhancer and either Rose Bengal or Riboflavin was used as a visible-light crosslinker...
April 15, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29656568/nanofiber-based-hydrogels-controllable-synthesis-and-multifunctional-applications
#2
REVIEW
Qiuxia Fu, Cheng Duan, Zishuo Yan, Yan Li, Yang Si, Lifang Liu, Jianyong Yu, Bin Ding
Nanofiber-based hydrogels (NFHGs) prepared by the combination of traditional hydrogels and novel nanofibers have demonstrated great potential in various application fields, owing to their integrated advantages of superhydrophilicity, high water-holding capacity, good biocompatibility, enhanced mechanical strength, and excellent structural tenability. In this review, a comprehensive overview of the structure design and synthetic strategy of NFHGs derived from electrospinning technique, weaving, freeze-drying, 3D printing, and molecular self-assembling method is provided...
April 14, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29656553/rational-fabrication-of-anti-freezing-non-drying-tough-organohydrogels-by-one-pot-solvent-displacement
#3
Fan Chen, Dan Zhou, Jiahui Wang, Tianzhen Li, Xiaohu Zhou, Tiansheng Gan, Stephan Handschuh-Wang, Xuechang Zhou
Tough hydrogels, polymeric network structures with excellent mechanical properties (e.g. high stretchability and toughness), are emerging soft materials, owing to their great potentials in applications spanning from soft robotics to tissue engineering. Despite their remarkably mechanical features, tough hydrogels exhibit two flaws, i.e., freezing around the icing temperatures of water and drying at arid conditions. Inspired by the applications of cryoprotectants (CPAs) in the inhibition of the icing of water in various biological samples (e...
April 14, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29656542/evaluation-of-permeability-and-fluid-wicking-in-woven-fiber-bone-scaffolds
#4
Jordon Gilmore, Freda Yin, Karen J L Burg
Research characterizing transport of nutrients and waste in tissue engineering scaffolds has led to the study of scaffold properties that contribute to permeability and porosity of the scaffold. Both permeability and porosity contribute to the transport properties of the scaffold; however, permeability relates to the degree to which pores are interconnected within the scaffold. This work evaluated permeability for woven polymer fiber scaffolds by modulating the following scaffold parameters: material combination, weave configuration, and fiber geometry...
April 15, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29656507/construction-and-application-of-a-xanthomonas-campestris-cgmcc15155-strain-that-produces-white-xanthan-gum
#5
Xiaohui Dai, Ge Gao, Mengmeng Wu, Weiying Wei, Jianmei Qu, Guoqiang Li, Ting Ma
In the industrial production of xanthan gum using Xanthomonas campestris CGMCC15155, large amounts of ethanol are required to extract xanthan gum from the fermentation broth and remove xanthomonadin impurities. To reduce the amount of ethanol and the overall production cost of xanthan gum, a xanthomonadin-deficient strain of CGMCC15155 was constructed by inserting the Vitreoscilla globin (vgb) gene, under the control of the LacZ promoter, into the region of the pigA gene, which is involved in xanthomonadin synthesis...
April 15, 2018: MicrobiologyOpen
https://www.readbyqxmd.com/read/29656492/pd-1-blockade-cellular-vesicles-for-cancer-immunotherapy
#6
Xudong Zhang, Chao Wang, Jinqiang Wang, Quanyin Hu, Benjamin Langworthy, Yanqi Ye, Wujin Sun, Jing Lin, Tianfu Wang, Jason Fine, Hao Cheng, Gianpietro Dotti, Peng Huang, Zhen Gu
Cancer cells resist to the host immune antitumor response via multiple suppressive mechanisms, including the overexpression of PD-L1 that exhausts antigen-specific CD8+ T cells through PD-1 receptors. Checkpoint blockade antibodies against PD-1 or PD-L1 have shown unprecedented clinical responses. However, limited host response rate underlines the need to develop alternative engineering approaches. Here, engineered cellular nanovesicles (NVs) presenting PD-1 receptors on their membranes, which enhance antitumor responses by disrupting the PD-1/PD-L1 immune inhibitory axis, are reported...
April 14, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29656479/fiber-length-and-concentration-synergistic-effect-on-mechanical-and-cellular-response-in-wet-laid-poly-lactic-acid-fibrous-scaffolds
#7
Andrew T Wood, Dominique Everett, Sanjay Kumar, Manoj K Mishra, Vinoy Thomas
In the area of biomaterials, fibers not only offer increased mechanical response, but also serve as an extracellular matrix mimicking morphology to direct cellular attachment and proliferation. While biologically similar in morphology, soft, and flexible hydrogel materials have low mechanical properties. For applications in tissue engineering, the lack of directional cues and attachment regions within the biogels is undesired as cells require a guide for adequate attachment and organized proliferation. In this work, we have investigated the role of poly(lactic acid) (PLA) fiber length and concentration as a reinforcement phase in a gelatin hydrogel matrix and the resultant mechanical and cellular responses...
April 15, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29656478/transplantation-of-neural-progenitor-cells-expressing-glial-cell-line-derived-neurotrophic-factor-into-the-motor-cortex-as-a-strategy-to-treat-amyotrophic-lateral-sclerosis
#8
Gretchen M Thomsen, Pablo Avalos, Annie A Ma, Mor Alkaslasi, Noell Cho, Livia Wyss, Jean-Philippe Vit, Marlesa Godoy, Patrick Suezaki, Oksana Shelest, Krystof S Bankiewicz, Clive N Svendsen
Early dysfunction of cortical motor neurons may underlie the initiation of amyotrophic lateral sclerosis (ALS). As such, the cortex represents a critical area of ALS research and a promising therapeutic target. In the current study, human cortical-derived neural progenitor cells engineered to secrete glial cell line-derived neurotrophic factor (GDNF) were transplanted into the SOD1G93A ALS rat cortex, where they migrated, matured into astrocytes, and released GDNF. This protected motor neurons, delayed disease pathology and extended survival of the animals...
April 15, 2018: Stem Cells
https://www.readbyqxmd.com/read/29656411/study-on-a-65-mer-peptide-mimetic-enzyme-with-gpx-and-sod-dual-function
#9
Juxin Yin, Jianjian Zhuang, Shaowu Lv, Ying Mu
Excessive reactive oxygen species (ROS) levels are harmful to the body. The peroxidase, GPx, and the superoxide dismutase, SOD, are important antioxidant enzymes for preventing ROS-induced damage. Se-CuZn-65P is an enzyme mimetic with dual GPx and SOD antioxidant function. However, currently, its production is mainly based on the cysteine auxotrophic expression technique, which is inefficient, expensive, and time consuming. In this study, we combined protein engineering and the chemical mutation method to synthesize Se-CuZn-65P...
April 15, 2018: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/29656408/in-silico-tracking-of-individual-species-accelerating-progress-in-macromolecular-engineering-and-design
#10
Dagmar R D'hooge
The beneficial use of computer simulations to track the microstructural evolution of individual species is highlighted in view of macromolecular engineering and design, considering two case studies on catalytic polymerization, and both "low" (<100) and "high" (>100) chain lengths, that is, i) atom transfer radical copolymerization of n-butyl acrylate and styrene aiming at the synthesis of functional macrospecies of "identical' chain length; and ii) chain shuttling polymerization of ethylene and 1-octene toward the production of segmented block copolymers with "soft" and "hard" segments...
April 14, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29656323/study-of-carbon-nanotube-rich-impedimetric-recognition-electrode-for-ultra-low-determination-of-polycyclic-aromatic-hydrocarbons-in-water
#11
Jose Muñoz, Cristina Navarro-Senent, Nuria Crivillers, Marta Mas-Torrent
Carbon nanotubes (CNTs) have been studied as an electrochemical recognition element for the impedimetric determination of priority polycyclic aromatic hydrocarbons (PAHs) in water, using hexocyanoferrate as a redox probe. For this goal, an indium tin oxide (ITO) electrode functionalized with a silane-based self-assembled monolayer carrying CNTs has been engineered. The electroanalytical method, which is similar to an antibody-antigen assay, is straightforward and exploits the high CNT-PAH affinity obtained via π-interactions...
April 14, 2018: Mikrochimica Acta
https://www.readbyqxmd.com/read/29656308/bacterial-lipid-modification-of-icp11-and-a-new-elisa-system-applicable-for-wssv-infection-detection
#12
Vidhyapriya Murugan, Krishnan Sankaran
In ELISA, a popular analytical diagnostic tool, the stable non-covalent immobilization (coating) of hydrophilic proteins/peptides on to hydrophobic polystyrene surface has remained a major common challenge. Recombinant bacterial lipid modification of proteins in Escherichia coli system has been shown in this study to solve this problem owing to the hydrophobic anchorage provided by three fatty acyl groups in N-acyl-S-diacylglyceryl Cys at the N-terminus. Exploiting this first post-translational protein engineering, the most abundantly expressed white spot syndrome viral protein ICP11 was lipid-modified and tested as a new target in a new ELISA method useful to shrimp farming...
April 14, 2018: Marine Biotechnology
https://www.readbyqxmd.com/read/29656241/material-properties-of-ultra-high-molecular-weight-polyethylene-comparison-of-tension-compression-nanomechanics-and-microstructure-across-clinical-formulations
#13
Louis G Malito, Sofia Arevalo, Adam Kozak, Stephen Spiegelberg, Anuj Bellare, Lisa Pruitt
This is the first study to simultaneously measure material properties in tension, compression, nanoindentation as well as microstructure (crystallinity and lamellar level properties) across a wide variety of clinically relevant ultra-high molecular weight polyethylene (UHMWPE) formulations. Methodologies for the measurement of UHMWPE mechanical properties-namely elastic modulus, yield stress, yield strain, ultimate strength, energetic toughness, Poisson's ratio, hardness and constitutive variables-are evaluated...
April 3, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29656237/vascularized-microfluidic-organ-chips-for-drug-screening-disease-models-and-tissue-engineering
#14
REVIEW
Tatsuya Osaki, Vivek Sivathanu, Roger D Kamm
Vascularization of micro-tissues in vitro has enabled formation of tissues larger than those limited by diffusion with appropriate nutrient/gas exchange as well as waste elimination. Furthermore, angiocrine signaling from the vasculature may be essential in mimicking organ-level functions in these micro-tissues. In drug screening applications, the presence of an appropriate blood-organ barrier in the form of a vasculature and its supporting cells (pericytes, appropriate stromal cells) may be essential to reproducing organ-scale drug delivery pharmacokinetics...
April 12, 2018: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/29656235/effective-cancer-immunotherapy-in-mice-by-polyic-imiquimod-complexes-and-engineered-magnetic-nanoparticles
#15
Ana Isabel Bocanegra Gondan, Ane Ruiz-de-Angulo, Aintzane Zabaleta, Nina Gómez Blanco, Beatriz Macarena Cobaleda-Siles, María Jesús García-Granda, Daniel Padro, Jordi Llop, Blanca Arnaiz, María Gato, David Escors, Juan C Mareque-Rivas
Encouraging results are emerging from systems that exploit Toll like receptor (TLR) signaling, nanotechnology, checkpoint inhibition and molecular imaging for cancer immunotherapy. A major remaining challenge is developing effective, durable and tumour-specific immune responses without systemic toxicity. Here, we report a simple and versatile system based on synergistic activation of immune responses and direct cancer cell killing by combined TLR ligation using polyIC as TLR3 and imiquimod (R837) as TLR7 agonist, in combination with the model antigen ovalbumin (OVA) and phospholipid micelles loaded with zinc-doped iron oxide magnetic nanoparticles (MNPs)...
April 3, 2018: Biomaterials
https://www.readbyqxmd.com/read/29656204/surface-hydroxylation-regulates-cellular-osteogeneses-on-tio-2-and-ta-2-o-5-nanorod-films
#16
Liming Wang, Beibei Zhou, Zongguang Liu, Lingqing Dong, Kui Cheng, Wenjian Weng
Titanium and tantalum have been widely used for orthopedic and dental implant applications. However, how their inherent surface features regulate cellular osteogeneses still remains elusive. In this study, we engineered two distinct TiO2 and Ta2 O5 nanorod films as the two model oxidized surfaces to investigate their intrinsic osteogenic behaviors. The results indicated that the distinctive gradient on zeta potential against pH, corresponding to the deprotonation rate, but not the hydroxyl amount or hydroxylation polarity played a critical role on the cellular osteogenic performance...
April 5, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29656191/instability-diagnosis-and-syntrophic-acetate-oxidation-during-thermophilic-digestion-of-vegetable-waste
#17
Dong Li, Yi Ran, Lin Chen, Qin Cao, Zhidong Li, Xiaofeng Liu
Effective process monitoring and instability diagnosis are important for stable anaerobic digestion (AD) of vegetable waste (VW). In order to evaluate the performance of thermophilic digestion of VW, to make early diagnosis for instability after organic overload, and to reveal the dynamics of microbial community under different running states, thermophilic AD of VW was carried out under improved organic loading rates (OLR) of 0.5-2.5 g volatile solid (VS)/(L ∙ d) in this study. Gaseous parameters including volumetric methane production rate (VMPR), CH4 , CO2 , and H2 concentrations, and liquid parameters including pH, oxidation-reduction potential, volatile fatty acid (VFA), and total alkalinity (TA), bicarbonate alkalinity (BA), intermediate alkalinity (IA), and ammonia, were monitored...
April 10, 2018: Water Research
https://www.readbyqxmd.com/read/29656075/3d-printed-scaffolds-with-bioactive-elements-induced-photothermal-effect-for-bone-tumor-therapy
#18
Yaqin Liu, Tao Li, Hongshi Ma, Dong Zhai, Cuijun Deng, Jinwu Wang, Shangjun Zhuo, Jiang Chang, Chengtie Wu
For treatment of bone tumor and regeneration of bone defects, the biomaterials should possess the ability to kill tumor cells and regenerate bone defect simultaneously. To date, there are a few biomaterials possessing such dual functions, the disadvantages, however, such as long-term toxicity and degradation, restrict their application. Although bioactive elements have been incorporated into biomaterials to improve their osteogenic activity, there is no report about elements-induced functional scaffolds for photothermal tumor therapy...
April 12, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29656072/enhanced-wound-healing-of-tissue-engineered-human-corneas-through-altered-phosphorylation-of-the-creb-and-akt-signal-transduction-pathways
#19
Camille Couture, Pascale Desjardins, Karine Zaniolo, Lucie Germain, Sylvain L Guérin
The cornea is a transparent organ, highly specialized and unique that is continually subjected to abrasive forces and occasional mechanical or chemical trauma because of its anatomical localization. Upon injury, the extracellular matrix (ECM) rapidly changes to promote wound healing through integrin-dependent activation of specific signal transduction mediators whose contribution is to favor faster closure of the wound by altering the adhesive and migratory properties of the cells surrounding the damaged area...
April 12, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29655988/tissue-engineering-still-facing-a-long-way-ahead
#20
REVIEW
Parichehr Hassanzadeh, Fatemeh Atyabi, Rassoul Dinarvand
Tissue engineering (TE) has provided promising perspectives to overcome the limited efficiency of the conventional treatment options or organ transplantation. Considerable advances in stem cell therapies and biomaterials science and development of delivery systems capable to mimic the production of growth factors may offer treatment breakthroughs in a variety of diseases. Meanwhile, proper vascularization, creation of the complex tissues, tissue quality, functional integration between the graft and host tissues, and the potential risks of chromosomal instability, mutations, tumorigenesis, or unexpected events have remained challenging...
April 12, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
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