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https://www.readbyqxmd.com/read/28109144/-interferon-regulatory-factor-5-irf5-regulates-the-differentiation-of-bone-marrow-derived-macrophages-in-mice
#1
Kang Sun, Jianguo Qu, Jixiang Chen, Shengchun Dang, Songbing He, Jin Zhang, Rong Xie, Yun Wang, Jianxin Zhang
Objective To investigate the expression differences of interferon regulatory factor 5 (IRF5) between M1 and M2 macrophages derived from mouse bone marrow and the effects of small interfering RNA targeting IRF5 gene (IRF5 siRNA) on macrophage differentiation. Methods With the treatment of IFN-γ and lipopolysaccharide (LPS), mouse bone marrow-derived macrophages were differentiated into M1 macrophages; while with the treatment of IL-4, mouse bone marrow-derived macrophages were differentiated into M2 macrophages...
February 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28109143/-decreased-number-and-immune-activity-of-splenic-t-lymphocytes-in-mice-exposed-to-hypoxia-at-high-altitude
#2
Xiaona Zhang, Jidong Li, Fangjie Hu, Shilan Gao, Xiaoyan Pu, Sheng Yong
Objective To explore the changes of splenic T lymphocyte subsets and functions in mice under high-altitude hypoxic conditions. Methods After mice were exposed to an altitude of 400 m, 2200 m and 4200 m for 30 days, ELISA was used to detect the concentrations of interleukin-4 (IL-4) and interferon-γ (IFN-γ) in the cultured splenocyte supernatant; MTT assay was used to analyze the proliferation of splenic T lymphocytes; flow cytometry was performed to examine the alterations of splenic T lymphocyte subsets...
February 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28109017/clostridium-butyricum-b1-alleviates-high-fat-diet-induced-steatohepatitis-in-mice-via-enterohepatic-immunoregulation
#3
Da Zhou, Qin Pan, Xiao-Lin Liu, Rui-Xu Yang, Yuan-Wen Chen, Chang Liu, Jian-Gao Fan
BACKGROUND AND AIM: Enterohepatic immunologic derangement is associated with nonalcoholic steatohepatitis (NASH). Here, we investigated whether Clostridium butyricum B1 (CB) would be an effective immune-targeted substance to attenuate steatohepatitis in mice. METHODS: Thirty mice were randomized into a control group fed with common forage, a high-fat diet (HFD) group fed a HFD for 16 weeks, and a HFD + CB group treated with CB for the latter 8 weeks. Inflammation- or metabolism-associated genes in the liver or epididymal fat tissue were quantified, intrahepatic and intestinal immune factors were detected...
January 20, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28108985/the-th2-gene-cluster-unraveled-role-of-rhs6
#4
EDITORIAL
Cameron H Flayer, Angela Haczku
Although the transcription factors that regulate T helper (Th) type 2 cytokine production (IL-4, IL-5, and IL-13) are possible novel therapeutic targets, we lack a detailed understanding of the mechanisms that regulate the transcription of these cytokines. In this issue of Allergy, Hwang et al. studied the role of a specific DNA region (a cis-acting element called Rad50 hypersensitive site 6) RHS6, in the development of allergic airway inflammation. RHS6 is found in the Th2 cytokine "locus control region" but its role in activation of the IL-4, IL-5, and IL-13 genes was unknown...
January 20, 2017: Allergy
https://www.readbyqxmd.com/read/28108850/baicalein-promotes-neuronal-and-behavioral-recovery-after-intracerebral-hemorrhage-via-suppressing-apoptosis-oxidative-stress-and-neuroinflammation
#5
Ning Wei, Yinghai Wei, Binru Li, Linlin Pang
Intracerebral hemorrhage (ICH) is an important public health problem in neurology, which is not only associated with high mortality but also leading to disability. Yet no satisfactory treatment has been developed. The secondary injury that resulted from a number of self-destructive processes such as neuroinflammation, apoptosis and oxidative stress, is the key factor contributing to ICH-induced brain damage. Baicalein has been proved to improve neuronal functional recovery in rat model of subarachnoid hemorrhage and ischemic brain damage...
January 21, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28107868/effect-of-ppar%C3%AE-agonist-rosiglitazone-on-the-secretion-of-th2-cytokine-in-asthma-mice
#6
Ji-Hui Yu, Li Long, Zhi-Xiao Luo, Jie-Ru You
OBJECTIVE: To explore the effect of PPARγ agonist (rosiglitazone) on the secretion of Th2 cytokines and the proportion of immune cell subsets in asthma mice. METHODS: Ovalbumin (OVA)-sensitized mice were used to build asthma models. Those mice were divided into the normal control group, model group and rosiglitazone group. Differences of the changes in lung histopathology of mice in the three groups were observed through hematoxylin and eosin (HE) strain, and the numbers of the total cells, eosinophils and neutrophils in BALF of mice in the three groups were compared...
January 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28107754/hyperoside-attenuates-ova-induced-allergic-airway-inflammation-by-activating-nrf2
#7
Peng Ye, Xi-Liang Yang, Xing Chen, Cai Shi
Allergic airways disease (AAD) is one of the most common medical illnesses that is associated with an increased allergic airway inflammation. Hyperoside, an active compound isolated from Rhododendron brachycarpum G. Don, has been reported to have anti-inflammatory effect. The aim of this study was to analyze the protective effect of hyperoside on OVA-induced allergic airway inflammation in mice. In the present study, the mouse asthma model was induced by given OVA and hyperoside was administrated 1h before OVA challenge...
January 17, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28106783/extract-of-polygala-tenuifolia-alleviates-stress-exacerbated-atopy-like-skin-dermatitis-through-the-modulation-of-protein-kinase-a-and-p38-mitogen-activated-protein-kinase-signaling-pathway
#8
Bongjun Sur, Bombi Lee, Ye Seul Yoon, Pooreum Lim, Riwon Hong, Mijung Yeom, Hyang Sook Lee, Hijoon Park, Insop Shim, Hyejung Lee, Young Pyo Jang, Dae-Hyun Hahm
Atopic dermatitis (AD) and stress create a vicious cycle: stress exacerbates atopic symptoms, and atopic disease elicits stress and anxiety. Targeting multiple pathways including stress and allergic inflammation is, therefore, important for treating AD. In this study, we investigated the remedial value of Polygala tenuifolia Willd. (PTW) for treating immobilization (IMO) stress-exacerbated atopy-like skin dermatitis and its underlying mechanism. Trimellitic anhydride (TMA) was applied to dorsal skin for sensitization and subsequently both ears for eliciting T-cell-dependent contact hypersensitivity in mice, which underwent 2 h-IMO stress and PTW administration for the latter 6 and 9 days in the ear exposure period of TMA, respectively...
January 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28106273/the-immunoglobulin-superfamily-member-cd200r-identifies-cells-involved-in-type-2-immune-responses
#9
Lars H Blom, Britta C Martel, Lau F Larsen, Camilla V Hansen, Malene P Christensen, Nanna Juel-Berg, Thomas Litman, Lars K Poulsen
BACKGROUND: The pathology of allergic diseases involves type 2 immune cells, such as Th2, ILC2, and basophils exerting their effect by production of IL-4, IL-5, and IL-13. However, surface receptors that are specifically expressed on type 2 immune cells are less well documented. The aim of this investigation was to identify surface markers associated with type 2 inflammation. METHODS: Naïve human CD4(+) T-cells were short-term activated in the presence or absence of IL-4, and analysed for expression of >300 cell-surface proteins...
January 20, 2017: Allergy
https://www.readbyqxmd.com/read/28105558/immunology-of-bee-venom
#10
REVIEW
Daniel Elieh Ali Komi, Farzaneh Shafaghat, Ricardo D Zwiener
Bee venom is a blend of biochemicals ranging from small peptides and enzymes to biogenic amines. It is capable of triggering severe immunologic reactions owing to its allergenic fraction. Venom components are presented to the T cells by antigen-presenting cells within the skin. These Th2 type T cells then release IL-4 and IL-13 which subsequently direct B cells to class switch to production of IgE. Generating venom-specific IgE and crosslinking FcεR1(s) on the surface of mast cells complete the sensitizing stage in allergic individuals who are most likely to experience severe and even fatal allergic reactions after being stung...
January 20, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28105144/sesamin-attenuates-allergic-airway-inflammation-through-the-suppression-of-nuclear-factor-kappa-b-activation
#11
Liangchang Li, Hongmei Piao, Mingyu Zheng, Zhewu Jin, Liguang Zhao, Guanghai Yan
The aim of the present study is to determine the role of sesamin, the most abundant lignan in sesame seed oil, on the regulation of allergic airway inflammation in a murine asthma model. A BALB/c mouse model with allergic asthma was used to evaluate the effects of sesamin on nuclear factor-kappa B (NF-κB) activation. An enzyme-linked immunosorbent assay was used to determine protein expression in bronchoalveolar lavage (BAL) fluids. Hematoxylin and eosin staining was performed to examine histological changes...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28103916/tim-1-defines-a-human-regulatory-b-cell-population-that-is-altered-in-frequency-and-function-in-systemic-sclerosis-patients
#12
Octavio Aravena, Ashley Ferrier, Madhvi Menon, Claudia Mauri, Juan Carlos Aguillón, Lilian Soto, Diego Catalán
BACKGROUND: Systemic sclerosis (SSc) is a systemic autoimmune disease characterized by excessive production of extracellular matrix by fibroblasts on skin and internal organs. Although Th2 cells have been involved in fibroblast stimulation, hyperactivated B cells may also play an important role. Regulatory B cells (Bregs) are cells capable of inhibiting inflammatory responses and controlling autoimmune diseases. Although many Breg populations have in common the ability to produce high amounts of IL-10, a unique surface marker defining most human Bregs is lacking...
January 19, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28103386/paraoxonase-1-activity-is-related-to-trichinella-spiralis-induced-hepatitis-in-rats
#13
Ayman Samir Farid, Eman Mohamed Fath, Shogo Mido, Nariaki Nonaka, Yoichiro Horii
BACKGROUND: Little is known about the potential adverse effects of a chronic zoonotic nematode Trichinella spiralis infection on hepatic inflammation and its relationship to paraoxonase (PON)-1 and butyrylcholinesterase (BuChE) activities. Therefore, we aimed to examine the effects of T. spiralis infection on hepatic synthesis of PON1. METHODS: Wistar rats were infected with 2500 first-stage larvae of T. spiralis and serum PON1 and BuChE activities were evaluated...
January 19, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28102058/neonatal-immune-state-is-influenced-by-maternal-allergic-rhinitis-and-associated-with-regulatory-t-cells
#14
Lu Tan, Jing Ou, Zezhang Tao, Yonggang Kong, Yu Xu
PURPOSE: Maternal influences contribute to the origin of allergic diseases, but the mechanisms are not clear. The current literature prompted the role of epigenetics in the development of allergic diseases. We sought to investigate the roles of regulatory T (Treg) cells and Forkhead box p3 (Foxp3) DNA methylation in the process of maternal transmission of allergic rhinitis (AR) susceptibility. METHODS: BALB/c female mice (AR mother) were sensitized by intraperitoneal injection of Dermatophagoides pteronyssinus (Der p) 1 on day 1 and 7...
March 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28102022/the-flavonoid-7-4-dihydroxyflavone-prevents-dexamethasone-paradoxical-adverse-effect-on-eotaxin-production-by-human-fibroblasts
#15
Changda Liu, Nan Yang, Xiaoke Chen, Jody Tversky, Jixun Zhan, Mirna Chehade, Rachel L Miller, Xiu-Min Li
Eotaxin/CCL-11 is a major chemoattractant that contributes to eosinophilic inflammation in asthma. Glucocorticoids inhibit inflammation, but long-time exposure may cause paradoxical adverse effects by augmenting eotaxin/CCL-11production. The aim of this study was to determine if 7,4'-dihydroxyflavone (7,4'-DHF), the eotaxin/CCL11 inhibitor isolated from Glycyrrhiza uralensis, reduces in vitro eotaxin production induced by long-time dexamethasone (Dex) exposure, and if so, to elucidate the mechanisms of this inhibition...
January 19, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28101568/puerarin-inhibits-m2-polarization-and-metastasis-of-tumor-associated-macrophages-from-nsclc-xenograft-model-via-inactivating-mek-erk-1-2-pathway
#16
Honggang Kang, Jing Zhang, Baozhong Wang, Meirong Liu, Jun Zhao, Mengxiang Yang, Yingxue Li
Non-small cell lung carcinoma (NSCLC) metastasis is responsible for most of cancer-related mortality. The tumor associated macrophages (TAMs) are known to be crucial cells in lung cancer and are usually divided into two antagonistic types, M1 and M2. Puerarin has a wide spectrum of pharmacological properties. The present study explores puerarin on macrophage polarization and metastasis of NSCLC. The results demonstrated that puerarin inhibited tumor growth and tumor volumes in NSCLC xenograft model, increased M1 markers [CD197+, inducible nitric oxide synthase (iNOS)+, CD40+)] and reduced M2 markers (CD206+, Arg-1+ and CD163+)...
February 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28101335/novel-snps-in-il-17f-and-il-17a-genes-associated-with-somatic-cell-count-in-chinese-holstein-and-inner-mongolia-sanhe-cattle
#17
Tahir Usman, Yachun Wang, Chao Liu, Yanghua He, Xiao Wang, Yichun Dong, Hongjun Wu, Airong Liu, Ying Yu
BACKGROUND: Bovine mastitis is the most common and costly disease of lactating cattle worldwide. Apart from milk somatic cell count (SCC) and somatic cell score (SCS), serum cytokines such as interleukin-17 (IL-17) and interleukin-4 (IL-4) may also be potential indicators for bovine mastitis. The present study was designed to investigate the effects of single nucleotide polymorphisms (SNPs) in bovine IL-17F and IL-17A genes on SCC, SCS and serum cytokines in Chinese Holstein and Inner-Mongolia Sanhe cattle, and to compare the mRNA expression variations of the cows with different genotypes...
2017: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/28099879/high-dose-baff-receptor-specific-mab-sirna-conjugate-generates-fas-expressing-b-cells-in-lymph-nodes-and-high-affinity-serum-autoantibody-in-a-myasthenia-mouse-model
#18
Naazneen Ibtehaj, Karl E Anderson, Ruksana Huda
We investigated potential therapeutic effects of a conjugate of BAFF receptor specific- monoclonal antibody and short interference RNA in a mouse model of myasthenia gravis (EAMG). Whereas high-dose siRNA conjugate resulted in significant accumulation of Fas expressing CD19+/ B220+ cells and concurrent expression of type 1 interferon in lymph nodes, low-dose conjugate did not induce FAS expression but caused marked BAFF receptor deficiency in lymph nodes that was further associated with improved MG symptoms...
January 15, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28099628/elevated-plasma-concentrations-of-s100-calcium-binding-protein-b-and-tumor-necrosis-factor-alpha-in-children-with-autism-spectrum-disorders
#19
Selin Aktan Guloksuz, Osman Abali, Esin Aktas Cetin, Sema Bilgic Gazioglu, Gunnur Deniz, Abdurrahman Yildirim, Ivana Kawikova, Sinan Guloksuz, James F Leckman
Objective: To investigate plasma concentrations of S100B (a calcium-binding protein derived primarily from the glia) and inflammatory cytokines in children with autism and the relationship between S100B and cytokine concentrations. Methods: Plasma levels of S100B, tumor necrosis factor alpha (TNF-α), interferon gamma, interleukin (IL)-1β, IL-4, IL-6, IL-10, and IL-17A were measured in 40 unmedicated children with autism and 35 normally developing healthy children...
January 12, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28099521/nuclear-localization-and-cleavage-of-stat6-is-induced-by-kaposi-s-sarcoma-associated-herpesvirus-for-viral-latency
#20
Chong Wang, Caixia Zhu, Fang Wei, Shujun Gao, Liming Zhang, Yuhong Li, Yanling Feng, Yin Tong, Jianqing Xu, Bin Wang, Zhenghong Yuan, Erle S Robertson, Qiliang Cai
Emerging evidence implies that STAT6 plays an important role in both the adaptive and innate immune responses to virus infection. Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic γ-herpesvirus agent associated with several human malignancies, including Kaposi's sarcoma (KS) and primary effusion lymphomas (PELs). Previously, we demonstrated that KSHV blocks IL-4-induced STAT6 phosphorylation and retains a basal IL-13/STAT6 constitutive activation for cell survival and proliferation. However, the mechanism by which KSHV regulates STAT6 remains largely unknown...
January 2017: PLoS Pathogens
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