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https://www.readbyqxmd.com/read/29456655/effect-of-immune-tolerance-induced-by-immature-dendritic-cells-and-ctla4-ig-on-systemic-lupus-erythematosus-an-in-vivo-study
#1
Cuili Huang, Lidan Zhang, Fang Ling, Sijian Wen, Yanyan Luo, Hui Liu, Jingping Liu, Wenjun Zheng, Ming Liang, Jian Sun, You-Kun Lin
Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disease in which tissue damage is caused by autoantibodies. The induction of specific immune tolerance, including the utilization of immune regulatory cells, may enhance the therapeutic effects of organ transplantation in patients with SLE. Furthermore, inhibiting immune responses has been reported to be an effective treatment for SLE. However, few studies have explored the association between an increased immune tolerance and a decreased immune response in SLE treatment...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29454234/diarylheptanoid-from-rhizomes-of-curcuma-kwangsiensis-dck-inhibited-imiquimod-induced-dendritic-cells-activation-and-th1-th17-differentiation
#2
Qing Liu, Wei Yin, Ling Han, Jiaoyan Lv, Bingji Li, Yuli Lin, Qingsheng Mi, Rui He, Chuanjian Lu
BACKGROUND AND OBJECT: Dendritic cells (DCs) are critical for initiating the activation and differentiation of T cells in inflammatory diseases including psoriasis. Curcuma kwangsiensis S.G. Lee & C.F. Liang is a herb for treating psoriasis and we previously found Diarylheptanoid from rhizomes of Curcuma kwangsiensis (DCK) inhibited keratinocytes proliferation. However, it is unknown whether DCK influences DC functions. Thus we aimed to explore whether DCK affect the major immunological functions of DCs...
February 14, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29447484/cationic-dda-tdb-liposome-as-a-mucosal-vaccine-adjuvant-for-uptake-by-dendritic-cells-in-vitro-induces-potent-humoural-immunity
#3
Wenjing Qu, Na Li, Rui Yu, Wenbao Zuo, Tingting Fu, Wenling Fei, Yanhui Hou, Yanhua Liu, Jianhong Yang
The cationic dimethyldioctadecylammonium/trehalose 6,6,9-dibehenate (DDA/TDB) liposome is as a strong adjuvant system for vaccines, with remarkable immunostimulatory activity. The mucosal administration of vaccines is a potential strategy for inducing earlier and stronger mucosal immune responses to infectious diseases. In this study, we assessed whether the intranasal administration of cationic DDA/TDB liposomes combined with influenza antigen A (H3N2) can be used as a highly efficacious vaccine to induce mucosal and systemic antibody responses...
February 15, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29445372/robust-phenotypic-activation-of-eosinophils-during-experimental-toxocara-canis-infection
#4
Joice Margareth de Almeida Rodolpho, Luciana Camillo, Márcio Sobreira Silva Araújo, Elaine Speziali, Jordana Grazziela Coelho-Dos-Reis, Ricardo de Oliveira Correia, Débora Meira Neris, Olindo Assis Martins-Filho, Andréa Teixeira-Carvalho, Fernanda de Freitas Anibal
Eosinophils are multifunctional cells that have cytotoxic proinflammatory activities and stimulate CD4 + T-cells in experimental models of allergy and parasitic infections. Eosinophils, when exposed to antigens, are activated, expressing the CD38/CD69 molecules and exhibited increased expression of major histocompatibility complex (MHC-II), CD80 and CD86, suggesting they play a role upon Toxocara canis antigen stimulation. In the present study, we evaluated the profile of eosinophils using conventional and image flow cytometry upon experimental T...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29424313/mesenchymal-stem-cells-inhibited-dendritic-cells-via-the-regulation-of-stat1-and-stat6-phosphorylation-in-experimental-autoimmune-uveitis
#5
L Dong, X Chen, H Shao, L Bai, X Li, X Zhang
PURPOSE: We have previously reported that MSCs inhibited experimental autoimmune uveitis (EAU) in rodent models induced by either uveitogenic antigens or antigen-specific T cells. In this study, we explored the inhibitory mechanisms of MSCs on dendritic cells (DCs) in EAU. METHODS: We collected the DCs from the lymph nodes of MSC treated or untreated EAU rats, as well as bone marrow derived DCs cultured in vitro with or without MSC treatment. The levels of costimulatory molecules of CD80, CD86, CD40, OX40L and suppressors of cytokine signaling (SOCS1, SOCS2, and SOCS3) on these DCs were analyzed by flow Cytometry...
February 7, 2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/29416316/durvalumab-an-investigational-anti-pd-l1-monoclonal-antibody-for-the-treatment-of-urothelial-carcinoma
#6
REVIEW
Izak Faiena, Amy L Cummings, Anna M Crosetti, Allan J Pantuck, Karim Chamie, Alexandra Drakaki
Our expanding knowledge of immunotherapy for solid tumors has led to an explosion of clinical trials aimed at urothelial carcinoma. The primary strategy is centered on unleashing the immune system by releasing the inhibitory signals propagated by programmed cell death-1 (PD-1) and its ligand programmed cell death ligand-1 (PD-L1). Many antibody constructs have been developed to block these interactions and are used in clinical trials. The Food and Drug Administration has already approved a number of checkpoint inhibitors such as anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA4) monoclonal antibodies including ipilimumab; anti-PD-1 monoclonal antibodies including nivolumab and pembrolizumab; anti-PD-L1 antibodies including atezolizumab, avelumab, and durvalumab...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29408047/phenotypic-and-functional-modulations-of-porcine-macrophages-by-interferons-and-interleukin-4
#7
Carmen A Sautter, Gaël Auray, Sylvie Python, Artur Summerfield
Considering that macrophage functions are strongly impacted by the local tissue environment and the type of immune response, the aim of this study was to carefully set the methodological baseline for phenotype and functions of polarized porcine monocyte-derived macrophages. To this end, macrophages were generated in autologous serum alone or with colony-stimulating factor (CSF)-1 or CSF-2, and subsequently polarized with interferon (IFN)γ, interleukin-4 or IFNβ. IFNγ promoted expression of MHC class I, MHC class II, CD11a, and CD40 as well as LPS-induced IL-6 and IL-12...
January 30, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29402722/cd80-cd86-signaling-contributes-to-the-proinflammatory-response-of-staphylococcus-aureus-in-the-airway
#8
Dane Parker
It was posited that the initial host response to Staphylococcus aureus is a contributing factor in the pathogenesis of acute pneumonia. Having previously observed that T cells play a negative role in the pathogenesis of acute pneumonia to S. aureus the contribution of the CD80/CD86 pathway in pathogenesis was investigated. Mice lacking CD80 and CD86 had significantly improved survival in a mouse model of acute S. aureus pneumonia. This was accompanied by significant reductions in several proinflammatory cytokines, including TNF, MIP-2, IL-1β, IL-17 and IL-6, as well as increased numbers of viable alveolar macrophages...
February 2, 2018: Cytokine
https://www.readbyqxmd.com/read/29401118/how-does-abatacept-really-work-in-rheumatoid-arthritis
#9
Michael Bonelli, Clemens Scheinecker
PURPOSE OF REVIEW: The purpose of this review is to summarize the current knowledge concerning the mechanisms of action of Abatacept in patients with rheumatoid arthritis. RECENT FINDINGS: Abatacept (CTLA-4Ig) represents a soluble, recombinant, fully humanized fusion protein, comprising the extracellular domain of CTLA-4 and the Fc portion of IgG1. Abatacept binds to the costimulatory molecules CD80 and CD86 on antigen-presenting cells (APC), thereby blocking interaction with CD28 on T cells...
February 3, 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29397454/reduced-antigen-presentation-capability-and-modified-inflammatory-immunosuppressive-cytokine-expression-of-induced-monocyte-derived-dendritic-cells-from-peripheral-blood-of-piglets-infected-with-porcine-circovirus-type-2
#10
Ning Yang, Jiandong Li, Qian Yang, Jinzeng Qiao, Defeng Cui, Fenghua Liu, Huanrong Li, Shuanghai Zhou
The efficiency of immune responses and host defense against pathogens largely depends on the function of dendritic cells (DCs). Porcine circovirus type 2 (PCV2) infection causes viremia and extensive modulation of immune activities in the blood. The objective of the present study was to investigate the effects of PCV2 infection in vivo on the immunological function of DCs induced from peripheral blood monocytes (MoDCs). At different points after infection with PCV2, peripheral blood monocytes from PCV2-infected pigs were used to induce differentiation of DCs in vitro...
February 3, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29393209/therapeutic-role-for-tsp-2-antibody-in-a-murine-asthma-model
#11
Kai Li, En Ping Huang, Jin Su, Ping Zhu, Jun Lin, Shen Qiu Luo, Cui Lan Yang
BACKGROUND: Specific immunotherapy, including agonists for Toll-like receptor 2 (TLR2), have been shown to protect from allergies and to have a high immunomodulatory capacity. METHODS: A new antibody, TSP-2, reactive against an epitope of the extracellular domain of TLR2, was identified. The effect of the antibody on dendritic cells was assessed by immunohistochemistry, Western blot, and flow cytometric analysis. The effect of TSP-2 in a murine asthma model induced with ovalbumin (OVA) was assessed...
January 27, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29392706/effect-of-olive-oil-phenolic-compounds-on-osteoblast-differentiation
#12
L Melguizo-Rodríguez, F J Manzano-Moreno, E De Luna-Bertos, A Rivas, J Ramos-Torrecillas, C Ruiz, O García-Martínez
BACKGROUND: Osteoporosis is a skeletal disorder characterized by compromised bone strength that predisposes individuals to an increased risk of fracture. Previous in vivo and in vitro studies have reported that phenolic compounds present in extra virgin olive oil have a beneficial effect on osteoblasts in terms of increase cell proliferation. The aim of this study was to determine whether phenolic compounds present in olive oil could modify the expression of cell differentiation markers on osteoblasts...
February 2, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29390972/establishment-of-malignantly-transformed-dendritic-cell-line-su3-ihdctc-induced-by-glioma-stem-cells-and-study-on-its-sensitivity-to-resveratrol
#13
Xifeng Fei, Anqi Wang, Delin Wang, Xan Meng, Jiawei Ma, Lei Hong, Ruwei Qin, Aidong Wang, Jun Dong, Qiang Huang, Zhimin Wang
BACKGROUND: As a factor contributing to the tumor cell drug resistance, tumor microenvironment (TME) is being paid increasingly attention. However, the drug resistance of malignantly transformed cells in TME has rarely been revealed. This paper is designed to investigate the sensitivity of malignantly transformed cell line (ihDCTC) induced by glioma stem cells (GSCs) in TME to chemotherapeutic drugs. METHODS: (1) Establishment of ihDCTC cell line,The bone marrow cells from enhanced green fluorescent protein (EGFP) transgenic nude mice were employed to culture the dendritic cells (DCs) in vitro, which were then co-cultured with red fluorescence protein (RFP) transgenic GSCs (SU3) to obtain ihDCTC (2) Res and Cis were used to intervene in the growth of abovemetioned cell lines in vitro and Res treated in bearing ihDCTC tumor mice, followed by evaluating their drug sensitivity and changes in key signaling proteins via half maximal inhibitory concentration (IC50), tumor mass and immunostaining method...
February 2, 2018: BMC Immunology
https://www.readbyqxmd.com/read/29390097/phase-ii-trial-of-galiximab-anti-cd80-monoclonal-antibody-plus-rituximab-calgb-50402-follicular-lymphoma-international-prognostic-index-flipi-score-is-predictive-of-upfront-immunotherapy-responsiveness
#14
M S Czuczman, J P Leonard, S Jung, J L Johnson, E D Hsi, J C Byrd, B D Cheson
No abstract text is available yet for this article.
January 29, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29385715/different-achilles-tendon-pathologies-show-distinct-histological-and-molecular-characteristics
#15
Franka Klatte-Schulz, Susann Minkwitz, Aysha Schmock, Nicole Bormann, Alper Kurtoglu, Serafeim Tsitsilonis, Sebastian Manegold, Britt Wildemann
Reasons for the development of chronic tendon pathologies are still under debate and more basic knowledge is needed about the different diseases. The aim of the present study was therefore to characterize different acute and chronic Achilles tendon disorders. Achilles tendon samples from patients with chronic tendinopathy (n = 7), chronic ruptures (n = 6), acute ruptures (n = 13), and intact tendons (n = 4) were analyzed. The histological score investigating pathological changes was significantly increased in tendinopathy and chronic ruptures compared to acute ruptures...
January 30, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29382418/-knockdown-of-indoleamine-2-3-dioxygenase-2-ido2-gene-inhibits-tumor-growth-and-enhances-immune-function-in-mice-bearing-melanoma
#16
Yanling Liu, Huan Liu, Yingqing Xiang, Xiaoyan Chen, Ping Xu, Weiping Min
Objective To study the role of indoleamine 2, 3-dioxygenase 2 (IDO2) in anti-tumor therapy and its effect on the immune response when using IDO2 as therapeutic target. Methods B16-BL6 cells were used to construct mouse xenografted melanoma model. IDO2-shRNA that contained IDO2-siRNA or control shRNA (scrambled-shRNA) was injected hydrodynamically via the tail vein to treat melanoma. The tumor size was measured by vernier caliper. Flow cytometry was performed to analyze the percentage of regulatory T cells (Tregs), T cell apoptosis rate in draining lymph nodes and the expressions of co-stimulatory molecules on splenic dendritic cells (DCs) from different treatment groups...
December 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/29380393/leishmania-amazonensis-induces-modulation-of-costimulatory-and-surface-markers-molecules-in-human-macrophages
#17
Solange Dos Santos Costa, Márcia Cristina Fornazim, Alexandre Eduardo Nowill, Selma Giorgio
Manipulation of costimulatory and surface molecules that shape the extent of immune responses by Leishmania is suggested as one of the mechanisms of evading the host's defenses. The experiments reported here were designed to evaluate the expression of CD11b, CD11c, CD14, CD18, CD54, CD80, CD86, CD206, MHC class II and TLR-2 (Toll-like receptor 2) in human macrophages infected with L. amazonensis. Phenotypic evaluation revealed a negative modulation in CD11b, CD11c, CD14, CD18, CD54 and MHC class II molecules, depending on the level of infection...
January 30, 2018: Parasite Immunology
https://www.readbyqxmd.com/read/29371126/a-positive-feedback-loop-between-il-1%C3%AE-lps-and-neu1-may-promote-atherosclerosis-by-enhancing-a-pro-inflammatory-state-in-monocytes-and-macrophages
#18
Irina Sieve, Melanie Ricke-Hoch, Martina Kasten, Karin Battmer, Britta Stapel, Christine S Falk, Matthias S Leisegang, Axel Haverich, Michaela Scherr, Denise Hilfiker-Kleiner
Inflammation plays an important role in atherosclerosis, a notion supported by the beneficial effects of the IL-1β inhibitor canakinumab in the CANTOS trial. Sialic acids (Sias), components of the surface glycocalyx, regulate intercellular and intermolecular interactions. We investigated the expression of the Sia cleaving enzyme neuraminidase-1 (NEU1) in atherosclerotic plaques and its potential role in inflammatory processes. In isolated mononuclear blood cells from patients with myocardial infarction, NEU1 expression was increased compared to healthy controls...
January 22, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29367743/vaccine-vectors-based-on-adenovirus-19a-64-exhibit-broad-cellular-tropism-and-potently-restimulate-hcmv-specific-t-cell-responses-ex-vivo
#19
Richard Kiener, Markus Fleischmann, Christiane Schwegler, Zsolt Ruzsics, Christian Thirion, Silke Schrödel, Benedikt Asbach, Ralf Wagner
Human Cytomegalovirus (HCMV) remains a major health burden and the development of a vaccine is a global priority. We developed new viral vectors delivering the T cell immunogens IE-1 and pp65 based on Adenovirus 19a/64 (Ad19a/64), a member of subgroup D. In this ex vivo study, the novel vectors were compared side by side to Ad5 or modified Vaccinia Ankara (MVA) strains expressing the same transgenes. We found that unlike Ad5, Ad19a/64 vectors readily transduce a broad panel of immune cells, including monocytes, T cells, NK cells and monocyte-derived dendritic cells (moDCs)...
January 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29360858/immunostimulatory-activity-of-water-extractable-polysaccharides-from-cistanche-deserticola-as-a-plant-adjuvant-in-vitro-and-in-vivo
#20
Ailian Zhang, Xiumei Yang, Quanxiao Li, Yu Yang, Gan Zhao, Bin Wang, Daocheng Wu
A safe and effective vaccine adjuvant is important in modern vaccines. Various Chinese herbal polysaccharides can activate the immune system. Cistanche deserticola (CD) is a traditional Chinese herb and an adjuvant candidate. Here, we confirmed that water-extractable polysaccharides of CD (WPCD) could modulate immune responses in vitro and in vivo. In a dose-dependent manner, WPCD significantly promoted the maturation and function of murine marrow-derived dendritic cells (BM-DCs) through up-regulating the expression levels of MHC-II, CD86, CD80, and CD40, allogenic T cell proliferation, and the yields of IL-12 and TNF-α via toll-like receptor4 (TLR4), as indicated by in vitro experiments...
2018: PloS One
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