Minsoo Khang, Ju Hyun Lee, Teresa Lee, Hee-Won Suh, Supum Lee, Alessandra Cavaliere, Amy Rushing, Luiz H Geraldo, Erika Belitzky, Samantha Rossano, Henk M de Feyter, Kwangsoo Shin, Anita Huttner, Martine F Roussel, Jean-Leon Thomas, Richard E Carson, Bernadette Marquez-Nostra, Ranjit S Bindra, W Mark Saltzman
The morbidity associated with pediatric medulloblastoma, in particular in patients who develop leptomeningeal metastases, remains high in the absence of effective therapies. Administration of substances directly into the cerebrospinal fluid (CSF) is one approach to circumvent the blood-brain barrier and focus delivery of drugs to the site of tumor. However, high rates of CSF turnover prevent adequate drug accumulation and lead to rapid systemic clearance and toxicity. Here, we show that PLA-HPG nanoparticles, made with a single-emulsion, solvent evaporation process, can encapsulate talazoparib, a PARP inhibitor (BMN-673)...
November 2023: Science Translational Medicine