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In Keun Jang, Hyun Joo Jung, O Kyu Noh, Doo-Hoon Lee, Kwang Chul Lee, Jun Eun Park
Mesenchymal stem cells (MSCs), derived from either bone marrow (BM) or Wharton's jelly (WJ), inhibit the proliferation of activated T cells, and interferon (IFN)‑γ serves an important role in this process. This process is B7‑homolog (H)1‑dependent during cell contact inhibition. However, the signaling pathway involved in B7‑H1 expression in MSCs remains largely undefined. The present study demonstrated activation of B7‑H1 by engaging signal transducer and activator of transcription (STAT)‑1 signaling in MSCs...
May 30, 2018: Molecular Medicine Reports
Joseph R Podojil, Ming-Yi Chiang, Igal Ifergan, Ronald Copeland, Linda N Liu, Sebastien Maloveste, Solomon Langermann, David Liebenson, Roumen Balabanov, Hongbo Chi, Lieping Chen, Dario A A Vignali, Stephen D Miller
The potent immune regulatory function of an agonistic B7-H4-Ig fusion protein (B7-H4Ig) has been demonstrated in multiple experimental autoimmune models; however, the identity of a functional B7-H4 receptor remained unknown. The biological activity of B7-H4 is associated with decreased inflammatory CD4+ T cell responses as supported by a correlation between B7-H4-expressing tumor-associated macrophages and Foxp3+ T cells within the tumor microenvironment. Recent data indicate that members of the semaphorin (Sema)/plexin/neuropilin (Nrp) family of proteins both positively and negatively modulate immune cell function...
June 13, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
Ming Wei, Shaoyang Wang, Pan Gu, Xiaoyu Ouyang, Shuxun Liu, Yiqing Li, Bolin Zhang, Baoqing Zhu
This study aimed to investigate the effect of Lactobacillus plantarum strains on quality improvement of bog bilberry juice. Bog bilberry juice with different pH conditions was fermented by Lactobacillus B7 or C8-1 strain. Physicochemical index, amino acids, phenolic compounds, and volatiles of these fermented juices were compared. Results indicated that Lactobacillus plantarum strains preferred to metabolize malic acid and reducing sugar in non-pH-adjusted juice (NJ, pH 2.65), whereas quinic and citric acids were largely consumed in pH-adjusted juice (AJ, pH 3...
June 2018: Journal of Food Science and Technology
Aravindhan Ganesan, Theinmozhi Arulraj, Tahir Choulli, Khaled H Barakat
BACKGROUND: Monoclonal antibodies blocking the Cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptor have revolutionized the field of anti-cancer therapy for the last few years. The human T-cell-based immune responses are modulated by two contradicting signals. CTLA-4 provides a T cell inhibitory signal through its interaction with B7 ligands (B7-1 and B7-2), while CD28 provides a stimulatory signal when interacting with the same ligands. A previous theoretical model has focused on understanding the processes of costimulatory and inhibitory complex formations at the synapse...
June 11, 2018: BMC Medical Informatics and Decision Making
Elisa Sauer, Bruna Gauer, Sabrina Nascimento, Jessica Nardi, Gabriela Göethel, Bárbara Costa, Douglas Correia, Ursula Matte, Mariele Charão, Marcelo Arbo, Albert Duschl, Angela Moro, Solange Cristina Garcia
Benzene is a recognized human carcinogen; however, there are still some gaps in the knowledge regarding the mechanism of toxicity of this organic solvent and potential early biomarkers for the damage caused by it. In a previous study, our research group demonstrated that the adhesion molecules of the immune system (B7.1 and B7.2) could be potential biomarkers in the early detection of immunotoxicity caused by benzene exposure. Therefore, this study was developed to deepen the understanding regarding this important topic, aiming to contribute to the comprehension of the benzene toxicity mechanism mediated by B7...
June 5, 2018: Environmental Research
Baolei Fan, Jinmao You, Yourui Suo, Chunqi Qian
A new labeling reagent for vitamin analysis, 2-amino-10-ethyl acridine ketone (AEAO), has been synthesized and successfully applied to the analysis of vitamin B3 and vitamin B7 in different tea samples. The reaction of AEAO with vitamins could proceed easily and quickly in the presence of 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride (EDC) as condensing reagent within 45 min. The derivatives exhibited excellent fluorescence property with excitation and emission wavelengths of 290 nm and 430 nm, respectively...
2018: PloS One
Apoorvi Chaudhri, Yanping Xiao, Alyssa N Klee, Xiaoxu Wang, Baogong Zhu, Gordon J Freeman
Programmed death ligand 1 (PD-L1)-mediated immune suppression regulates peripheral tolerance and is often co-opted by tumors to evade immune attack. PD-L1 binds to PD-1 but also binds to B7-1 (CD80) to regulate T-cell function. Binding interactions of PD-L1 with B7-1 and its functional role need further investigation to understand differences between PD-1 and PD-L1 tumor immunotherapy. We examined the molecular orientation of PD-L1 binding to B7-1 using cell-to-cell binding assays, ELISA, and flow cytometry...
June 5, 2018: Cancer Immunology Research
Wanbing Chen, You Wu, Gaofu Zhang, Mo Wang, Haiping Yang, Qiu Li
Primary nephrotic syndrome (PNS) is a devastating pediatric disorder. However, its mechanism remains unclear. Previous studies detected B7-1 in podocytes; meanwhile, γδ T cells play pivotal roles in immune diseases. Therefore, this study aimed to assess whether and how γδ T cells impact podocytes via the CD28/B7-1 pathway. WT and TCR δ -/- mice were assessed. LPS was used to induce nephropathy. Total γδ T and CD28+ γδ T cells were quantitated in mouse spleen and kidney samples. B7-1 and phosphor-SRC levels in the kidney were detected as well...
2018: BioMed Research International
Hao Wu, Wei-Wei Deng, Lei-Lei Yang, Wen-Feng Zhang, Zhi-Jun Sun
AIM: Immunohistochemistry was used to detect the expression of Stathmin 1 and Serine 38 phospho-Stathmin 1 (p-Stathmin 1S38 ) in head and neck squamous cell carcinoma (HNSCC) and research its correlation with clinical parameters, survival and expression of immune checkpoint molecules. RESULTS: Stathmin 1 and p-Stathmin 1S38 overexpression in primary HNSCC is associated with poor overall survival. Stathmin 1 expression is related to tumor size, category and lymph node status...
May 30, 2018: Biomarkers in Medicine
Alix Besançon, Tania Goncalves, Fabrice Valette, Caroline Mary, Bernard Vanhove, Lucienne Chatenoud, Sylvaine You
AIMS/HYPOTHESIS: The CD28/B7 interaction is critical for both effector T cell activation and forkhead box P3 (FOXP3)+ regulatory T cell (Treg) generation and homeostasis, which complicates the therapeutic use of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)-immunoglobulin fusion protein (CTLA-4Ig) in autoimmunity. Here, we evaluated the impact of a simultaneous and selective blockade of the CD28 and mammalian target of rapamycin (mTOR) pathways in the NOD mouse model of type 1 diabetes...
May 29, 2018: Diabetologia
Tae Kon Kim, Roy S Herbst, Lieping Chen
Despite the unprecedented tumor regression and long-term survival benefit observed with anti-programmed death (PD) [anti-PD-1 or anti-B7-homolog 1 (B7-H1)] therapy in patients with advanced cancers, a large portion of patients do not benefit from such treatment and a fraction of responders relapse. Current efforts to overcome resistance and improve efficacy of anti-PD therapy require a clear understanding of resistance and should precede current avenues using random combinations with available treatment regimens...
May 22, 2018: Trends in Immunology
Qin Yang, Wenjie Cao, Zi Wang, Jing Liu, Bin Zhang
Immune checkpoint proteins (ICPs) are regulators of immune system. The ICP dysregulation silences the host immune response to cancer-specific antigens, contributing to the occurrence and progress of various cancers. MiRNAs are regulatory molecules and function in mRNA silencing and post-transcriptional regulation of gene expression. MiRNAs modulate the immunity via ICPs have received increasing attention. Many studies have shown that the expressions of ICPs are directly or indirectly repressed by miRNAs in multiple types of cancers...
May 22, 2018: Cancer Letters
Ling Pei, Hai-Ru Li, Miao Yan, Qiang Chen, Yue-Wen Mu, Hai-Gang Lu, Yan-Bo Wu, Si-Dian Li
Recent joint experimental and theoretical investigations have shown that seashell-like C2 B28 is the smallest neutral borospherene reported to date, while seashell-like Cs B29- (1-) as a minor isomer competes with its quasi-planar counterparts in B29- cluster beams. Extensive global minimum searches and first-principles theory calculations performed in this work indicate that with two valence electrons detached from B29-, the B29+ monocation favors a seashell-like Cs B29+ (1+) much different from Cs B29- (1-) in geometry which is overwhelmingly the global minimum of the system with three B7 heptagonal holes in the front, on the back, and at the bottom, respectively, unveiling an interesting charge-induced structural transition from Cs B29- (1-) to Cs B29+ (1+)...
May 24, 2018: Physical Chemistry Chemical Physics: PCCP
Michail Ignatiadis, Gert Van den Eynden, Salgado Roberto, Marco Fornili, Yacine Bareche, Christine Desmedt, Françoise Rothé, Marion Maetens, David Venet, Esther Holgado, Virginia McNally, Astrid Kiermaier, Heidi M Savage, Timothy R Wilson, Javier Cortes, Andreas Schneeweiss, Karen Willard-Gallo, Elia Biganzoli, Christos Sotiriou
Background: There is an urgent requirement to identify biomarkers to tailor treatment in human epidermal growth factor receptor 2 (HER2)-amplified early breast cancer treated with trastuzumab/pertuzumab-based chemotherapy. Methods: Among the 225 patients randomly assigned to trastuzumab/pertuzumab concurrently or sequentially with an anthracycline-containing regimen or concurrently with an anthracycline-free regimen in the Tryphaena trial, we determined the percentage of tumor-infiltrating lymphocytes (TILs) at baseline in 213 patients, of which 126 demonstrated a pathological complete response (pCR; ypT0/is ypN0), with 28 demonstrating event-free survival (EFS) events...
May 18, 2018: Journal of the National Cancer Institute
Hannah A Blair
Atezolizumab (TECENTRIQ™), an immune checkpoint inhibitor, is an immunoglobulin G1 monoclonal antibody that binds to programmed death ligand 1 (PD-L1) and blocks its interactions with programmed death 1 and B7.1 receptors. Atezolizumab is approved as monotherapy in several countries worldwide for the treatment of patients with advanced non-small cell lung cancer (NSCLC) who have previously received chemotherapy. Approval was based on its clinical benefit in this setting in the phase II POPLAR and phase III OAK trials...
May 21, 2018: Targeted Oncology
S K Ram, L R Kumar, R D Tyagi, P Drogui
This study used the technical, economic analysis tool, SuperPro designer in evaluating a novel technology for simultaneous production of extracellular polymeric substance (EPS) and biodiesel using crude glycerol and secondary sludge. As renewable energy sources are depleting, the process utilizes municipal sewage sludge for production of EPS and biodiesel along with crude glycerol, which is a waste byproduct of biodiesel industry providing an alternate way for disposal of municipal sludge and crude glycerol...
May 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Melina E Marmarelis, Charu Aggarwal
PURPOSE OF REVIEW: Checkpoint blockade has changed the treatment landscape in non-small cell lung cancer (NSCLC), but single-agent approaches are effective for only a select subset of patients. Here, we will review the evidence for combination immunotherapies in NSCLC and the clinical data evaluating the efficacy of this approach. RECENT FINDINGS: Clinical trials evaluating combination PD-1 and CTLA-4 blockade as well as PD-1 in combination with agents targeting IDO1, B7-H3, VEGF, and EGFR show promising results...
May 8, 2018: Current Oncology Reports
Mohamed Hassany, Aisha Elsharkawy, Amr Maged, Mai Mehrez, Noha Asem, Ahmed Gomaa, Zeinab Mostafa, Bahaa Abbas, Mohamad Soliman, Gamal Esmat
BACKGROUND AND AIMS: Treatment of hepatitis C virus (HCV) after successfully treated hepatocellular carcinoma (HCC) becomes possible with the introduction of direct-acting antivirals because of their favorable efficacy, safety, and short period of treatment. Few data are available on the results of treatment using different direct-acting antiviral regimens in successfully treated HCC and a lot of debate about its role in tumor recurrence. METHODS: Sixty-two HCV-related HCC patients were enrolled in the study after successfully treated HCC; the studied population included either Child-Pugh 'A' or 'B7'...
May 1, 2018: European Journal of Gastroenterology & Hepatology
Tao Wang, Min Meng, Min Huang, Xinya Zhao
PURPOSE: The aim was to display variations of right bronchial tree. METHODS: The bronchial tree images of 238 patients were reconstructed using the postprocessing technique of CT. RESULTS: We revealed four cases rare bronchial branching patterns of right superior lobe. 1 case was referred to as tracheal bronchus. In 1 case, B1 was located in the place of the right superior lobar bronchus and B2 + 3 arose from the right merge of the IB...
May 3, 2018: Surgical and Radiologic Anatomy: SRA
Melanie B Thomas, Elizabeth Garrett-Mayer, Munazza Anis, Kate Anderton, Tricia Bentz, Andie Edwards, Alan Brisendine, Geoffrey Weiss, Abby B Siegel, Johanna Bendell, Ari Baron, Vinay Duddalwar, Anthony El-Khoueiry
OBJECTIVES: To investigate the clinical efficacy and tolerability of the combination of bevacizumab (B) and erlotinib (E) compared to sorafenib (S) as first-line treatment for patients with advanced hepatocellular carcinoma (HCC). METHODS: A total of 90 patients with advanced HCC, Child-Pugh class A-B7 cirrhosis, and no prior systemic therapy were randomly assigned (1: 1) to receive either 10 mg/kg B intravenously every 14 days and 150 mg E orally daily (n = 47) (B+E) or 400 mg S orally twice daily (n = 43)...
May 2, 2018: Oncology
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