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Jiang-tao Zhang, Mei Mei, Ce Jiang, Lei Feng, Jin Huang, Jia-jia Wang
PURPOSE: To explore the combined effects of recombinant human platelet-derived growth factor-BB(rhPDGF-BB)and recombinant human transforming growth factor-β1 (rhTGF-β1) on protein expression of FAK in osteolasts of the pressure side of orthodontic tooth in rats. METHODS: One hundred and sixty male Sprague-Dawley rats were randomly divided into 2 groups: experimental group(A) and control group(B). Each group was subdivided equally into 5 subgroups. Orthodontic tooth movement model was established...
August 2015: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
Dorte Eskesen, Lillian Jespersen, Birgit Michelsen, Peter J Whorwell, Stefan Müller-Lissner, Cathrine M Morberg
The aim of the present study was to investigate the effect of Bifidobacterium animalis subsp. lactis, BB-12®, on two primary end points - defecation frequency and gastrointestinal (GI) well-being - in healthy adults with low defecation frequency and abdominal discomfort. A total of 1248 subjects were included in a randomised, double-blind, placebo-controlled trial. After a 2-week run-in period, subjects were randomised to 1 or 10 billion colony-forming units/d of the probiotic strain BB-12® or a matching placebo capsule once daily for 4 weeks...
November 28, 2015: British Journal of Nutrition
Mauro Merli, Marco Moscatelli, Giorgia Mariotti, Umberto Pagliaro, Eugenia Raffaelli, Michele Nieri
PURPOSE: The objective of this parallel randomised controlled trial is to compare two bone substitutes and collagen membranes in a one-stage procedure for horizontal bone augmentation: anorganic bovine bone (Bio-Oss) and collagen porcine membranes (Bio-Gide) (BB group) versus a synthetic resorbable bone graft substitute made of pure β-tricalcium phosphate (Ceros TCP) and porcine pericardium collagen membranes (Jason) (CJ group). MATERIALS AND METHODS: Patients in need of implant treatment having at least one site with horizontal osseous defects at a private clinic in Rimini (Italy) were included in this study...
2015: European Journal of Oral Implantology
P J Marín, M T García-Gutiérrez, M E Da Silva-Grigoletto, T J Hazell
OBJECTIVES: To evaluate the effects of performing battling rope exercise with and without the addition of whole-body vibration (WBV) on muscle activity of the leg, trunk, and upper body. METHODS: Twenty-eight recreationally active university students completed 20-s of battling rope undulation for 6 separate conditions: 1) alternating arm motion no WBV -Alt_NoWBV; 2) alternating arm motion 30 Hz low amplitude WBV -Alt_30 Hz-L; 3) alternating arm motion 50 Hz high amplitude -Alt_50 Hz-H; 4) double arm motion no WBV -Double_NoWBV; 5) double arm motion 30Hz low amplitude WBV -Double_30Hz-L; 6) double arm motion 50 'Hz high amplitude -Double_50 Hz-H...
September 2015: Journal of Musculoskeletal & Neuronal Interactions
Hirotaka Uchimizu, Yoshinori Matsuwaki, Masahiko Kato, Nobuyosi Otori, Hiromi Kojima
BACKGROUND: Eosinophilic otitis media (EOM) is an intractable disease characterized by a remarkably viscous effusion and accumulation of numerous eosinophils in both the middle ear effusion and the mucosa. The key factors in EOM pathogenesis remain unclear. The purpose of this study is to identify the important factors involved in EOM pathogenesis. METHODS: Middle ear effusion samples were collected from 12 patients with EOM and 9 patients with secretory otitis media (SOM), as controls...
September 2015: Allergology International: Official Journal of the Japanese Society of Allergology
Seema Singh, Vimal Chandra Srivastava, Tapas Kumar Mandal
The present study reports use of the catalytic peroxidation (CPO) method for treatment of actual fertilizer industry wastewater (FIW) by using copper-loaded Santa Barbara amorphous-15 (Cu/SBA-15) catalyst. FIW consists of toxic nitrogenous and phosphorus containing compounds that are not easily degraded by the conventional physicochemical and biological treatment methods. In the present study, Box-Behnken (BB) experimental design methodology was used for optimization of three independent parameters namely catalytic dose (m), initial pH (pHo), and H2O2 concentration...
2015: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
Thomas M Mack, James E Norman, Edward Rappaport, Wendy Cozen
BACKGROUND: Hodgkin lymphoma in young adults is inexplicably linked to economic development. METHODS: We conducted a nested case-control study of the 656 servicemen with Hodgkin lymphoma diagnosed between ages 17 to 32 while on active duty in the U.S. military during 1950-68. Controls, chosen randomly from the servicemen on duty at the time, were matched on service, birth year, and induction date. Information came from preinduction records and military records for the period ending at onset or the equivalent date...
November 2015: Cancer Epidemiology, Biomarkers & Prevention
E Wilson Grandin, Mariell Jessup
No abstract text is available yet for this article.
October 6, 2015: Circulation
Larry A Allen, Gregg C Fonarow, Li Liang, Phillip J Schulte, Frederick A Masoudi, John S Rumsfeld, P Michael Ho, Zubin J Eapen, Adrian F Hernandez, Paul A Heidenreich, Deepak L Bhatt, Eric D Peterson, Harlan M Krumholz
BACKGROUND: Guidelines for heart failure (HF) recommend prescription of guideline-directed medical therapy before hospital discharge; some of these therapies are included in publicly reported performance measures. The burden of new medications for individual patients has not been described. METHODS AND RESULTS: We used Get With The Guidelines-HF registry data from 2008 to 2013 to characterize prescribing, indications, and contraindications for angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, β-blockers, aldosterone antagonists, hydralazine/isosorbide dinitrate, and anticoagulants...
October 6, 2015: Circulation
Fergus McCarthy, Aisling Doyle, Ali Khashan, Louise Kenny
BACKGROUND: Glycogen phosphorylase is a key enzyme in the regulation of glycogen metabolism and consists of three isoenzymes, including glycogen phosphorylase isoenzyme BB (GPBB). Pre-eclampsia, gestational hypertension, and small-for-gestational-age (SGA) infants are complications in about 15% of all nulliparous pregnancies. Biomarkers for these adverse pregnancy outcomes remain elusive. GPBB has been proposed as a potential biomarker for the detection of these adverse outcomes. We aimed to investigate this hypothesis...
February 26, 2015: Lancet
Martin Schlumberger, Barbara Jarzab, Maria E Cabanillas, Bruce Robinson, Furio Pacini, Douglas W Ball, Judith McCaffrey, Kate Newbold, Roger Allison, Renato G Martins, Lisa F Licitra, Manisha H Shah, Donald Bodenner, Rossella Elisei, Lynn Burmeister, Yasuhiro Funahashi, Min Ren, James P O'Brien, Steven I Sherman
PURPOSE: Positive results of phase I studies evaluating lenvatinib in solid tumors, including thyroid cancer, prompted a phase II trial in advanced medullary thyroid carcinoma (MTC). EXPERIMENTAL DESIGN: Fifty-nine patients with unresectable progressive MTC per Response Evaluation Criteria In Solid Tumors (RECIST) v1.0 within the prior 12 months received lenvatinib (24-mg daily, 28-day cycles) until disease progression, unmanageable toxicity, withdrawal, or death...
January 1, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
John C Mullaney, Susanna L Stephens, Daniel P Zaleski, Matthew J Sprawling, David P Tew, Nicholas R Walker, Anthony C Legon
A molecular complex of C2H2 and AuI has been generated and isolated in the gas phase through laser ablation of a gold surface in the presence of an expanding sample containing small percentages of C2H2 and CF3I in a buffer gas of argon. Rotational, B0, centrifugal distortion, ΔJ and ΔJK, and nuclear quadrupole coupling constants, χaa(Au), χbb(Au) - χcc(Au), χaa(I), and χbb(I) - χcc(I), are measured for three isotopologues of C2H2···AuI through broadband rotational spectroscopy. The complex is C2v and T-shaped with C2H2 coordinating to the gold atom via donation of electrons from the π-orbitals of ethyne...
September 17, 2015: Journal of Physical Chemistry. A
Takahiro Furukawa, Naoko Matsui, Koji Fujita, Hiroyuki Nodera, Fumitaka Shimizu, Katsuichi Miyamoto, Yukitoshi Takahashi, Takashi Kanda, Susumu Kusunoki, Yuishin Izumi, Ryuji Kaji
OBJECTIVE: We aimed to compare the cytokine and chemokine profiles of patients with multifocal motor neuropathy (MMN) with those of patients with progressive muscular atrophy (PMA) and amyotrophic lateral sclerosis (ALS) to investigate immunologic differences in the CNS. METHODS: CSF from 12 patients with MMN, 8 with PMA, 26 with sporadic ALS, and 10 with other noninflammatory neurologic disorders was analyzed for 27 cytokines and chemokines using the multiplex bead array assay...
October 2015: Neurology® Neuroimmunology & Neuroinflammation
M N Aznar, F J Linares, B Cosentino, A Sago, L La Sala, E León, S Duffy, A Perez
BACKGROUND: Bovine brucellosis (BB) is a zoonotic disease caused by Brucella abortus. BB is endemic in Argentina, where vaccination with Brucella abortus strain 19 is compulsory for 3-to-8 month-old heifers. The objectives of this study were to quantify the prevalence of BB and to identify factors associated with its occurrence, along with the spatial distribution of the disease, in the provinces of La Pampa and San Luis. A two-stage random sampling design was used to sample 8,965 cows (3,513 in La Pampa and 5,452 in San Luis) from 451 farms (187 in La Pampa and 264 in San Luis)...
2015: BMC Veterinary Research
Anne C Nilsson, Elin V Johansson-Boll, Inger M E Björck
Certain purified indigestible carbohydrates such as inulin have been shown to stimulate gut-derived hormones involved in glycaemic regulation and appetite regulation, and to counteract systemic inflammation through a gut microbiota-mediated mechanism. Less is known about the properties of indigestible carbohydrates intrinsic to food. The aim of this study was to investigate the possibility to affect release of endogenous gut hormones and ameliorate appetite control and glycaemic control by ingestion of a whole-grain cereal food product rich in NSP and resistant starch in healthy humans...
September 28, 2015: British Journal of Nutrition
Mugimane G Manjanatha, Sharon D Shelton, Lynne Haber, Bhaskar Gollapudi, Judith A MacGregor, Narayanan Rajendran, Martha M Moore
Chronic inhalation of vanadium pentoxide (V2O5) increases the incidence of alveolar/bronchiolar tumors in male and female B6C3F1 mice at 1, 2, or 4 mg/m(3). The genotoxicity of V2O5 has been extensively investigated in the literature with mixed results. In general, tests for gene mutations have been negative. Both positive and negative results were reported for clastogenicity in vitro with some reports suggesting aneugenic potential. In vivo, V2O5 was negative in the mouse micronucleus test (erythrocyte) and comet assay (lung)...
August 2015: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
Sohair M M Ragab, Sary Kh Abd Elghaffar, Tarek H El-Metwally, Gamal Badr, Mohamed H Mahmoud, Hossam M Omar
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disease with a complex pathophysiology. The clinical features of NAFLD include obesity, insulin resistance (IR) and dyslipidemia. Consumption of a diet high in saturated fats and sucrose is an important factor in the increasing occurrence of these metabolic disorders, primarily NAFLD and IR. We sought to assess the role of a high-fat, high-sucrose (HFS) diet in the promotion of NAFLD and to evaluate the effects of quercetin (Q), berberine (BB) and o-coumaric acid (CA) on modulation of these disorders...
2015: Lipids in Health and Disease
M Veith, Z Straňák, M Penčák, P Studený
UNLABELLED: 25-gauge pars plana vitrectomy with briliant blue assisted internal limiting membrane peeling and gas tamponade for idiopatic macular hole. PURPOSE: The evaluation of anatomic and visual outcomes in idiopatic macular holes treated with 25-gauge pars plana vitrectomy, briliant blue (BB) assisted internal limiting membrane (ILM) peeling and gas tamponade. MATERIALS AND METHODS: Retrospective analysis. 53 eyes of 52 patients (39 women, 13 men) of mean age 68,8 years (58-83) with the diagnosis of stage 2, 3, or 4 macular holes according to Gass Classification from 6/2012 to 7/2014 were included...
June 2015: Ceská a Slovenská Oftalmologie
D L Ríos, C López, J U Carmona
OBJECTIVES: To study, in normal cartilage explants (CEs) challenged with lipopolysaccharide (LPS), the temporal effects (at 48 and 96h) of leukocyte- and platelet-rich gel (L-PRG) and pure platelet-rich gel (P-PRG) supernatants on the production and degradation of platelet-associated growth factors (GFs) (platelet-derived GF isoform BB [PDGF-BB] and transforming growth factor beta-1 [TGF-β1]), pro-inflammatory (tumour necrosis factor alpha [TNF-α]) and anti-inflammatory cytokines (interleukin 4 [IL-4] and IL-1 receptor antagonist [IL-1ra])...
December 2015: Cytokine
Chih-Hsuan Chang, David J Nesbitt
The acetylenic CH stretch mode (ν1) of propargyl (H2CCCH) radical has been studied at sub-Doppler resolution (∼60 MHz) via infrared laser absorption spectroscopy in a supersonic slit-jet discharge expansion, where low rotational temperatures (Trot = 13.5(4) K) and lack of spectral congestion permit improved determination of band origin and rotational constants for the excited state. For the lowest J states primarily populated in the slit jet cooled expansion, fine structure due to the unpaired electron spin is resolved completely, which permits accurate analysis of electron spin-rotation interactions in the vibrationally excited states (εaa = - 518...
June 28, 2015: Journal of Chemical Physics
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