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peripheral nerve treatment

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https://www.readbyqxmd.com/read/29166664/is-there-a-reasonable-excuse-for-not-providing-post-operative-analgesia-when-using-animal-models-of-peripheral-neuropathic-pain-for-research-purposes
#1
Sara Hestehave, Gordon Munro, Rie Christensen, Tina Brønnum Pedersen, Lars Arvastson, Philip Hougaard, Klas S P Abelson
INTRODUCTION: The induction of neuropathic pain-like behaviors in rodents often requires surgical intervention. This engages acute nociceptive signaling events that contribute to pain and stress post-operatively that from a welfare perspective demands peri-operative analgesic treatment. However, a large number of researchers avoid providing such care based largely on anecdotal opinions that it might interfere with model pathophysiology in the longer term. OBJECTIVES: To investigate effects of various peri-operative analgesic regimens encapsulating different mechanisms and duration of action, on the development of post-operative stress/welfare and pain-like behaviors in the Spared Nerve Injury (SNI)-model of neuropathic pain...
2017: PloS One
https://www.readbyqxmd.com/read/29166306/the-surgical-management-of-nerve-gaps-present-and-future
#2
Samer Bassilios Habre, Grant Bond, Xi Lin Jing, Epameinondas Kostopoulos, Robert D Wallace, Petros Konofaos
Peripheral nerve injuries can result in significant morbidity, including motor and/or sensory loss, which can affect significantly the life of the patient. Nowadays, the gold standard for the treatment of nerve section is end-to-end neurorrhaphy. Unfortunately, in some cases, there is segmental loss of the nerve trunk. Nerve mobilization allows primary repair of the sectioned nerve by end-to-end neurorrhaphy if the gap is less than 1 cm. When the nerve gap exceeds 1 cm, autologous nerve grafting is the gold standard of treatment...
November 21, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29164745/fully-implantable-peripheral-nerve-stimulation-for-hemiplegic-shoulder-pain-a-multi-site-case-series-with-two-year-follow-up
#3
Richard D Wilson, Maria E Bennett, Vu Q C Nguyen, William C Bock, Michael W O'Dell, Thomas K Watanabe, Russell H Amundson, Harry A Hoyen, John Chae
OBJECTIVE: To explore the feasibility and safety of a single-lead, fully implantable peripheral nerve stimulation system for the treatment of chronic shoulder pain in stroke survivors. PARTICIPANTS: Participants with moderate to severe shoulder pain not responsive to conservative therapies for six months. METHODS: During the trial phase, which included a blinded sham introductory period, a percutaneous single-lead peripheral nerve stimulation system was implanted to stimulate the axillary nerve of the affected shoulder...
November 22, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29163522/the-vagus-nerve-in-the-neuro-immune-axis-implications-in-the-pathology-of-the-gastrointestinal-tract
#4
REVIEW
Bruno Bonaz, Valérie Sinniger, Sonia Pellissier
The vagus nerve (VN) is the longest nerve of the organism and a major component of the parasympathetic nervous system which constitutes the autonomic nervous system (ANS), with the sympathetic nervous system. There is classically an equilibrium between the sympathetic and parasympathetic nervous systems which is responsible for the maintenance of homeostasis. An imbalance of the ANS is observed in various pathologic conditions. The VN, a mixed nerve with 4/5 afferent and 1/5 efferent fibers, is a key component of the neuro-immune and brain-gut axes through a bidirectional communication between the brain and the gastrointestinal (GI) tract...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29159762/p2y12-receptor-upregulation-in-satellite-glial-cells-is-involved-in-neuropathic-pain-induced-by-hiv-glycoprotein-120-and-2-3-dideoxycytidine
#5
Zhihua Yi, Lihui Xie, Congfa Zhou, Huilong Yuan, Shuai Ouyang, Zhi Fang, Shanhong Zhao, Tianyu Jia, Lifang Zou, Shouyu Wang, Yun Xue, Bing Wu, Yun Gao, Guilin Li, Shuangmei Liu, Hong Xu, Changshui Xu, Chunping Zhang, Shangdong Liang
The direct neurotoxicity of HIV and neurotoxicity of combination antiretroviral therapy medications both contribute to the development of neuropathic pain. Activation of satellite glial cells (SGCs) in the dorsal root ganglia (DRG) plays a crucial role in mechanical and thermal hyperalgesia. The P2Y12 receptor expressed in SGCs of the DRG is involved in pain transmission. In this study, we explored the role of the P2Y12 receptor in neuropathic pain induced by HIV envelope glycoprotein 120 (gp120) combined with ddC (2',3'-dideoxycytidine)...
November 20, 2017: Purinergic Signalling
https://www.readbyqxmd.com/read/29159464/anti-mag-associated-cerebellar-ataxia-and-response-to-rituximab
#6
Panagiotis Zis, Dasappaiah Ganesh Rao, Nigel Hoggard, Ptolemaios Georgios Sarrigiannis, Marios Hadjivassiliou
BACKGROUND: Myelin-associated glycoprotein (MAG) is a glycoprotein specific to Schwann cells. Schwann cells produce myelin for nerve cells in the peripheral nervous system. MAG also plays a role in the central nervous system (CNS) by maintaining myelin integrity and inhibiting axonal regeneration from cerebellar neurons. There is a well-established link between distal demyelinating neuropathy and anti-MAG antibodies in patients with monoclonal gammopathy of unknown significance. We describe a series of five patients with anti-MAG antibodies with evidence of cerebellar rather than just sensory ataxia and our experience of treatment with rituximab...
November 20, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29157803/iridoid-glycosides-fraction-from-picrorhiza-kurroa-attenuates-cyclophosphamide-induced-renal-toxicity-and-peripheral-neuropathy-via-ppar-%C3%AE-mediated-inhibition-of-inflammation-and-apoptosis
#7
Supriya Sharma, Pallavi Sharma, Pankaj Kulurkar, Damanpreet Singh, Dinesh Kumar, Vikram Patial
BACKGROUND: Picrorhiza kurroa Royle (Scrophulariaceae) is an important medicinal herb being widely used in variety of ailments. PURPOSE: The present study was envisaged to evaluate the effects of iridoid glycosides enriched fraction (IGs) from Picrorhiza kurroa rhizome against cyclophosphamide (CP) -induced renal toxicity and peripheral neuropathy. METHODS: Mice in different groups were pretreated with 25, 50 and 100 mg/kg; p.o. doses of IGs for 21 days, followed by cyclophosphamide intoxication for consecutive two days...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29155701/an-ultrasonic-tool-for-nerve-conduction-block-in-diabetic-rat-models
#8
Yee Fun Lee, Chou-Ching Lin, Jung-Sung Cheng, Gin-Shin Chen
Nerve conduction block with a high intensity-focused ultrasound (HIFU) transducer has been performed in normal and diabetic animal models recently. HIFU can reversibly block the conduction of peripheral nerves without damaging the nerves while using an appropriate ultrasonic parameter. Temporary and partial block of the action potentials of nerves shows that HIFU has the potential to be a useful clinical treatment for pain relief. This work demonstrates the procedures for suppressing the action potentials of neuropathic nerves in diabetic rats in vivo using an HIFU transducer...
October 20, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29154935/ghrelin-alleviates-paclitaxel-induced-peripheral-neuropathy-by-reducing-oxidative-stress-and-enhancing-mitochondrial-anti-oxidant-functions-in-mice
#9
Nobuyuki Ishii, Hironobu Tsubouchi, Ayako Miura, Shigehisa Yanagi, Hiroaki Ueno, Kazutaka Shiomi, Masamitsu Nakazato
Paclitaxel is an effective chemotherapeutic agent, but has some treatment-limiting adverse effects that markedly decrease patients' quality of life. Peripheral neuropathy is one of these, and no treatment for it has been established yet. Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, is secreted from the stomach and has widespread effects on multiple systems. We investigated the pharmacological potential of ghrelin in preventing paclitaxel-induced peripheral neuropathy using wild-type mice, ghrelin-null mice, and growth hormone secretagogue receptor-null mice...
November 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29154689/peripheral-vagal-nerve-stimulation-modulates-the-nociceptive-withdrawal-reflex-in-healthy-subjects-a-randomized-cross-over-sham-controlled-study
#10
Roberto De Icco, Daniele Martinelli, Vito Bitetto, Mauro Fresia, Eric Liebler, Giorgio Sandrini, Cristina Tassorelli
Introduction The mechanism of action of non-invasive vagal nerve stimulation in the treatment of migraine is elusive. We studied its effect in a human model of pain, the nociceptive withdrawal reflex. Methods We enrolled 10 healthy subjects who underwent active non-invasive vagal nerve stimulation and sham treatment in a randomized, cross-over, sham-controlled study. Non-invasive vagal nerve stimulation was delivered with gammaCore®. The assessment of the nociceptive withdrawal reflex was performed at baseline (T0) and at 5 (T5) and 30 (T30) minutes after stimulation...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29154235/the-use-of-neurodynamic-techniques-in-the-conservative-treatment-of-carpal-tunnel-syndrome-a-critical-appraisal-of-the-literature
#11
Tomasz Wolny
BACKGROUND: Carpal tunnel syndrome (CTS) is the most common peripheral neuropathy, characterized by the presence of many sensory and motor abnormalities. In the physiotherapy of patients with CTS, neurodynamic tech-niques are very common, while the scientific literature does not show clear evidence of beneficial effects obtained by using these techniques. Therefore, the aim of this work was to critically evaluate the use of neurodynamic techniques in the conservative treatment of CTS...
October 31, 2017: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/29154053/acupuncture-and-kinesio-taping-for-the-acute-management-of-bell-s-palsy-a-case-report
#12
Derya Özmen Alptekin
BACKGROUND: Bell's palsy is an idiopathic, acute peripheral palsy of the facial nerve that supplies the muscles of facial expression. Despite an expected 70% full recovery rate, up to 30% of patients are left with potentially disfiguring facial weakness, involuntary movements, or persistent lacrimation. The most frequently used treatment options are corticosteroids and antiviral drugs. However, accompanying clinical conditions, such as uncontrolled diabetes, hypertension, gastrointestinal disturbances, polypharmacy of geriatric patients, and significant sequelae ratios, indicate the need for safe and effective complementary therapies that would enhance the success of the conventional interventions...
December 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29151170/the-function-of-the-cellular-prion-protein-in-health-and-disease
#13
REVIEW
Joel C Watts, Matthew E C Bourkas, Hamza Arshad
The essential role of the cellular prion protein (PrP(C)) in prion disorders such as Creutzfeldt-Jakob disease is well documented. Moreover, evidence is accumulating that PrP(C) may act as a receptor for protein aggregates and transduce neurotoxic signals in more common neurodegenerative disorders, such as Alzheimer's disease. Although the pathological roles of PrP(C) have been thoroughly characterized, a general consensus on its physiological function within the brain has not yet been established. Knockout studies in various organisms, ranging from zebrafish to mice, have implicated PrP(C) in a diverse range of nervous system-related activities that include a key role in the maintenance of peripheral nerve myelination as well as a general ability to protect against neurotoxic stimuli...
November 18, 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/29150945/development-of-an-in-vivo-mouse-model-of-discogenic-low-back-pain
#14
Changgui Shi, Vaskar Das, Xin Li, Ranjan Kc, Sujun Qiu, InSug O-Sullivan, Richard L Ripper, Jeffrey S Kroin, Fackson Mwale, Atiyayein A Wallace, Bingqian Zhu, Lan Zhao, Andre J van Wijnen, Mingliang Ji, Jun Lu, Gina Votta-Velis, Wen Yuan, Hee-Jeong Im
Discogenic Low back pain (DLBP) is extremely common and costly. Effective treatments are lacking due to DLBP's unknown pathogenesis. Currently, there are no in vivo mouse models of DLBP, which restricts research in this field. The aim of this study was to establish a reliable DLBP model in mouse that captures the pathological changes in the disc and allows longitudinal pain testing. The model was generated by puncturing the mouse lumbar discs (L4/5, L5/6, and L6/S1) and removing the nucleus pulposus using a microscalpel under the microscope...
November 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29150265/hypothesis-watershed-zones-in-the-human-eye-are-a-key-for-understanding-glaucomatous-retinal-damage
#15
Christian Albrecht May, Paul Rutkowski
The pathogenesis of glaucoma is complex which has led to numerous hypothesizes concerning the important factors creating this specific type of inner retinal degeneration namely apoptosis of retinal ganglion cells. We favor a primary vascular etiology and provide evidence that the pathogenesis of glaucoma should not be confined to changes exclusively at the optic nerve head but must include changes occurring in the peripheral retina with particular emphasis on the watershed zones of both the retina and choroid...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29149212/mycolactone-displays-anti-inflammatory-effects-on-the-nervous-system
#16
Caroline Isaac, Annie Mauborgne, Alfonso Grimaldi, Kemy Ade, Michel Pohl, Cristina Limatola, Yves Boucher, Caroline Demangel, Laure Guenin-Macé
BACKGROUND: Mycolactone is a macrolide produced by the skin pathogen Mycobacterium ulcerans, with cytotoxic, analgesic and immunomodulatory properties. The latter were recently shown to result from mycolactone blocking the Sec61-dependent production of pro-inflammatory mediators by immune cells. Here we investigated whether mycolactone similarly affects the inflammatory responses of the nervous cell subsets involved in pain perception, transmission and maintenance. We also investigated the effects of mycolactone on the neuroinflammation that is associated with chronic pain in vivo...
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29145979/current-ultrasound-application-in-the-foot-and-ankle
#17
REVIEW
Nahum Michael Beard, Robert Patrick Gousse
This article is a comprehensive review of the current utilizations of ultrasound in the treatment of orthopedic conditions of the foot and ankle. It reviews the diagnostic and interventional applications to commonly encountered lower-extremity ailments, including plantar fasciosis, tendinosis, and peripheral nerve disorders. It also outlines minimally invasive ultrasound-guided procedures and emerging therapies as alternatives to current treatments. These emerging therapies can be used to assist surgeons and provide options for patients needing intervention...
January 2018: Orthopedic Clinics of North America
https://www.readbyqxmd.com/read/29145495/regulatory-mechanism-of-ccn2-production-by-serotonin-5-ht-via-5-ht2a-and-5-ht2b-receptors-in-chondrocytes
#18
Ayaka Hori, Takashi Nishida, Shogo Takashiba, Satoshi Kubota, Masaharu Takigawa
Serotonin (5-hydroxytryptamine: 5-HT) is recognized as a neurotransmitter in the central nerve system and as a regulator of systemic blood pressure in the peripheral tissues. Recently, it was reported that 5-HT2 receptors (5-HT2Rs) were expressed in cartilage tissues lacking both vessels and neurons, suggesting possible novel functions of 5-HT during cartilage development and regeneration. Our previous data indicated that CCN family protein 2/connective tissue growth factor (CCN2/CTGF) plays a central role in cartilage development and regeneration...
2017: PloS One
https://www.readbyqxmd.com/read/29143216/self-perception-and-determinants-of-color-vision-in-parkinson-s-disease
#19
Alexander U Brandt, Hanna G Zimmermann, Timm Oberwahrenbrock, Justine Isensee, Thomas Müller, Friedemann Paul
Visual dysfunction is common in patients with Parkinson's disease (PD). The objective of this study was to investigate the perceived impact of visual dysfunction and especially color vision loss on PD patients, and to identify retinal and disease factors associated with color vision. Thirty PD patients and thirty-four healthy controls were included. Participants performed the Farnsworth-Munsell Hue-100 test (FMT). Patients answered the National Eye Institute Visual Function Questionnaire (NEI-VFQ), Unified Parkinson's Disease Rating Scale (UPDRS) assessment, and underwent optical coherence tomography with measurement of retinal nerve fiber layer, ganglion cell layer + inner plexiform layer (GCIPL), and outer nuclear and photoreceptor layer...
November 15, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29141716/hansen-s-disease-and-rheumatoid-arthritis-crossover-of-clinical-symptoms-a-case-series-of-18-patients-in-the-united-states
#20
Sarah M Labuda, John S Schieffelin, Jeffrey G Shaffer, Barbara M Stryjewska
Hansen's Disease (HD) is a rare, chronic granulomatous infection of the skin and peripheral nerves caused by the noncultivable organism Mycobacterium leprae. Arthritis is the third most common symptom of HD. Subjects with both confirmed HD on skin biopsy and chronic arthritis were identified at the National Hansen's Disease Program (NHDP). We conducted a series of medical chart reviews and extracted and logged personally deidentified data into a database and carried out descriptive analyses. Eighteen of 261 subjects presented to the NDHP with both HD and chronic arthritis between 2001 and 2015...
October 23, 2017: American Journal of Tropical Medicine and Hygiene
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