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https://www.readbyqxmd.com/read/26640577/successful-treatment-of-refractory-chronic-hand-eczema-with-calcipotriol-betamethasone-ointment-a-report-of-three-cases
#1
Min Yang, Jian-Min Chang
Chronic hand eczema (CHE) is a common skin disorder with frequent relapses, and its treatment comprises a challenge due to its uncertain etiology. In particular, certain cases of CHE exhibiting severe keratinization have a very poor response to various treatments. The Daivobet ointment, a complex product comprising calcipotriol and betamethasone, has been successfully used for the treatment of patients with plaque-type psoriasis for ~10 years; however, there are few reports on the effect of the ointment on other skin disorders of abnormal keratinization, such as eczema...
November 2015: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/25078031/solid-lipid-nanoparticles-loaded-topical-gel-containing-combination-drugs-an-approach-to-offset-psoriasis
#2
Rahul Sonawane, Harshad Harde, Mahesh Katariya, Satyam Agrawal, Sanyog Jain
AIM: The primary aim of present work was to develop effective combination drug therapy for topical treatment of psoriasis. METHODS: Betamethasone dipropionate and calcipotriol loaded solid lipid nanoparticles (CT-BD-SLNs) were prepared by hot melt high shear homogenization technique, which were then incorporated in Carbopol gel matrix. The anti-psoriatic potential was tested by sequential in vitro (skin permeation and dermal distribution, anti-proliferative effect in HaCaT cells) and in vivo (Draize patch irritation, transepidermal water loss (TEWL) and anti-psoriatic mouse tail studies) experiments...
December 2014: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/24684740/expert-recommendations-the-use-of-the-fixed-combination-calcipotriol-and-betamethasone-dipropionate-gel-for-the-topical-treatment-of-psoriasis
#3
REVIEW
E Daudén, A Bewley, J Lambert, G Girolomoni, F Cambazard, K Reich
Treatment non-adherence is a general challenge and a complex problem. It is a key factor that impacts the 'real-life' effectiveness of topical treatments for chronic disorders, such as psoriasis. Here, we provide our expert opinion on the real-life effectiveness of topical psoriasis treatment, using the fixed combination gel (Daivobet(®) gel; calcipotriol plus betamethasone dipropionate) as a case study. The fixed combination gel is a first-line topical treatment for mild-to-moderate psoriasis, developed to be the gold-standard therapy for psoriasis patients...
May 2014: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/23437972/practicability-of-combined-treatment-with-calcipotriol-betamethasone-gel-daivobet%C3%A2-gel-and-improvement-of-quality-of-life-in-patients-with-psoriasis
#4
Michael Sticherling, Christoph Eicke, Tobias Anger
BACKGROUND: The successful treatment of psoriasis depends not only on the efficacy of the medication but also on patientsí acceptance and adherence to the prescribed regimen. PATIENTS AND METHODS: In this non-interventional, prospective trial 579 patients with psoriasis were treated once daily with the fixed combination of calcipotriol 50 μg/g plus betamethasone 0.5 mg/g (Daivobet® Gel) for 4 weeks. Comparing the new medication to their previous treatment, patients assessed their quality of life by means of the Dermatology Life Quality Index (DLQI), reported their therapy- associated burden in daily life by the Psoriasis Disability Index (PDI) and assessed how easy the new medication was to employ...
May 2013: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/21967117/spotlight-on-calcipotriene-betamethasone-dipropionate-in-psoriasis-vulgaris-of-the-trunk-limbs-and-scalp
#5
REVIEW
Paul L McCormack
Calcipotriene (calcipotriol)/betamethasone dipropionate (calcipotriene 50 μg/g and betamethasone 0.5 mg/g) is a fixed-dose combination of a vitamin D3 analog and a corticosteroid indicated for the once-daily, topical treatment of psoriasis vulgaris of the trunk, limbs, and scalp in adults. Both the ointment (Daivobet®; Dovobet®) and gel (Xamiol®; Daivobet® Gel; Dovobet® Gel) formulations of calcipotriene/betamethasone dipropionate can be used to treat psoriasis vulgaris of the trunk and/or limbs, although the gel formulation was specifically developed for the treatment of scalp psoriasis...
December 1, 2011: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/21504248/calcipotriol-betamethasone-dipropionate-a-review-of-its-use-in-the-treatment-of-psoriasis-vulgaris-of-the-trunk-limbs-and-scalp
#6
REVIEW
Paul L McCormack
Calcipotriol/betamethasone dipropionate (calcipotriol 50 μg/g and betamethasone 0.5 mg/g) is a fixed-dose combination of a vitamin D(3) analogue and a corticosteroid indicated for the once-daily, topical treatment of psoriasis vulgaris of the trunk, limbs and scalp in adults. Both the ointment (Daivobet®; Dovobet®) and gel (Xamiol®; Daivobet® Gel; Dovobet® Gel) formulations of calcipotriol/betamethasone dipropionate can be used to treat psoriasis vulgaris of the trunk and/or limbs, although the gel formulation was specifically developed for the treatment of scalp psoriasis...
April 16, 2011: Drugs
https://www.readbyqxmd.com/read/21293107/calcipotriol-plus-betamethasone-dipropionate-gel-compared-with-tacalcitol-ointment-and-the-gel-vehicle-alone-in-patients-with-psoriasis-vulgaris-a-randomized-controlled-clinical-trial
#7
RANDOMIZED CONTROLLED TRIAL
Richard G B Langley, Aditya Gupta, Kim Papp, Denise Wexler, Marie Louise Østerdal, Dušica Curčić
OBJECTIVE: To establish the efficacy and safety of once daily treatment of Daivobet®/Dovobet® gel in patients with psoriasis vulgaris, relative to tacalcitol ointment and the gel vehicle alone. METHODS: 458 patients with at least moderately severe disease were randomized in 3 treatment arms for an 8-week period. Treatment was investigator blinded, and treatment success was defined as patients with an Investigator's Global Assessment of 'clear' or 'almost clear' at week 8...
2011: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/20684147/short-and-long-term-safety-assessment-of-a-two-compound-ointment-containing-calcipotriene-betamethasone-dipropionate-taclonex-daivobet-dovobet-ointment-hypothalamic-pituitary-adrenal-axis-function-in-patients-with-psoriasis-vulgaris
#8
RANDOMIZED CONTROLLED TRIAL
Colin Fleming, Cecilia Ganslandt, Graham P Leese
The two-compound ointment (Taclonex/Daivobet/Dovobet ointment) combining calcipotriene 50 microg/g and betamethasone 0.5 mg/g (as dipropionate) is very effective in the treatment of psoriasis vulgaris. There is a possibility that hypothalamo-pituitary-axis (HPA) suppression may occur if the potent corticosteroid component is absorbed to a sufficient extent. The effect of the two-compound ointment on HPA axis function was assessed in two studies. Study 1 was a four-week, double-blind study which compared the effects of the two-compound ointment with betamethasone 0...
August 2010: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/20017943/comparison-of-the-effects-of-vitamin-d-products-in-a-psoriasis-plaque-test-and-a-murine-psoriasis-xenograft-model
#9
RANDOMIZED CONTROLLED TRIAL
Peter H Kvist, Lars Svensson, Oskar Hagberg, Vibeke Hoffmann, Kaare Kemp, Mads A Røpke
The aim of the present study was to compare the effects of Daivobet and calcipotriol on clinical score and biomarker responses in a modified version of the Scholtz-Dumas psoriasis plaque assay. Furthermore, it was the aim to compare the effects of calcipotriol and betamethasone in the murine psoriasis xenograft model. Twenty four patients with psoriasis were treated topically once daily for three weeks, whereas the grafted mice were treated for four weeks. Clinical responses were scored twice weekly and biopsies were taken at the end of each study to analyse for skin biomarkers by histology and immunohistochemistry...
2009: Journal of Translational Medicine
https://www.readbyqxmd.com/read/19821787/prior-authorization-for-topical-psoriasis-treatments-is-it-cost-beneficial-for-managed-care
#10
Rajesh Balkrishnan, Monali J Bhosle, Alan B Fleischer, Steven R Feldman
OBJECTIVE: The introduction of novel therapeutic options for psoriasis has raised managed care's interest in controlling costs associated with dermatological treatments. Prior authorization (PA) can be a successful way of managing costs. However, experience with topical treatments for acne suggests that PA may not be cost-effective. The role of managed care in dermatology and the potential impact of PA requirements for novel topical therapies for psoriasis are considered. METHODS: Using a model based on recent survey data, total annual cost estimates for a managed care organization to cover psoriasis treatment with a topical agent with or without PA requirements were calculated and compared...
May 2010: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/19726275/the-desire-study-psoriasis-patients-satisfaction-with-topical-treatment-using-a-fixed-combination-of-calcipotriol-and-betamethasone-dipropionate-in-daily-clinical-practice
#11
MULTICENTER STUDY
Birgitta Wilson Claréus, Ronald Houwing, Jens H Sindrup, Suzanne Wigchert
Daivobet (Dovobet) is a fixed combination ointment of calcipotriol and betamethasone dipropionate. The real-life clinical use of calcipotriol/betamethasone dipropionate treatment was assessed in this multi-centre, single-group, non-interventional study. Patients with psoriasis vulgaris who had a recent calcipotriol/betamethasone dipropionate prescription prior to the study start evaluated their satisfaction with the treatment after a 4-week course and after repeated courses for up to 6 months. Of the 1224 patients enrolled, 81...
November 2009: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/19243481/pharmacoeconomic-model-of-topical-treatment-options-of-mild-to-moderate-psoriasis-vulgaris-in-germany
#12
Matthias Augustin, Marc Radtke, Anke van Engen, Cornelia Ruedig, Christina Lapp, Ulrich Moehling
BACKGROUND: Psoriasis vulgaris is one of the most common dermatologic diseases in Germany with a prevalence of about 2%. Along with efficacy and safety, costs are an important criterion for selecting appropriate therapy for this chronic disease. The majority of the patients with mild to moderate psoriasis vulgaris can be successfully treated with topical therapy alone. The most important agents are vitamin D(3) analogs and corticosteroids either as single agents or in a fixed combination (Daivobet)...
April 2009: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/19075342/-new-perspectives-in-treatment-of-bounded-forms-of-psoriasis
#13
N V Tsiskarashvili, N I Tsiskarashvili
29 patients with bounded forms of psoriasis (18-52 years old 19 men and 10 women since several months to 15 years suffering from the named illness) once in the morning were treated with Daivobet (ointment for external application). By the 10-14th day after treatment full regress of skin fine eruptions and significant reduction of large nidus and intensity of peeling were observed in 20 patients. PASI index decreased by 60%, that allow use Daivonex ointment (1-2-times a day. For strengthening the effect duration of treatment was about 4-6 weeks...
November 2008: Georgian Medical News
https://www.readbyqxmd.com/read/18728704/calcipotriol-betamethasone-dipropionate-in-the-treatment-of-psoriasis-vulgaris
#14
Efstratios Vakirlis, Athanasios Kastanis, Demetrios Ioannides
Psoriasis is one of the most common skin diseases. The mainstay of treatment for the vast majority of patients is topical therapy. A rising first-line treatment modality for psoriasis vulgaris is the two-compound ointment containing calcipotriol 50 mug/g plus betamethasone dipropionate 0.5 mg/g (Dovobet((R)), Daivobet((R)), Taclonex((R))), which combines a vitamin D analog and a corticosteroid. This innovative formulation preserves the activity and bioavailability of the two components and many clinical studies have demonstrated that it has a greater efficacy, tolerability, and a rapid onset of action compared with its individual ingredients or tacalcitol...
February 2008: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/17823519/cost-effectiveness-model-of-topical-treatment-of-mild-to-moderate-psoriasis-vulgaris-in-germany-a-comparison-of-calcipotriol-betamethasone-daivobet-dovobet-taclonex-once-daily-and-a-morning-evening-non-fix-combination-of-calcipotriol-and-betamethasone
#15
COMPARATIVE STUDY
M Augustin, P Peeters, M Radtke, U Moehling, C Lapp
BACKGROUND: Psoriasis vulgaris requires lifelong treatment associated with considerable health cost. Studies showed that a combination of a steroid and a vitamin D(3) analogue is more effective than both compounds in monotherapy. OBJECTIVE: To determine the cost-effectiveness of a fix calcipotriol/betamethasone combination (Daivobet/Dovobet/Taclonex) compared to a morning/evening non-fix calcipotriol/betamethasone combination in psoriasis treatment. METHODS: A Markov model (discrete-time stochastic process based on transitions between health states) with 2 treatment arms (Daivobet/Dovobet/Taclonex vs...
2007: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/17551662/calcipotriol-and-betamethasone-dipropionate-for-the-treatment-of-psoriasis-a-52-week-study
#16
J W P Toole
Psoriasis is a common skin disease affecting 1%-3% of the world's population with significant impacts on quality of life. There is a great need for therapies that are efficacious and safe, not only for the short-term, but also for long-term management. Dovobet/ Daivobet/ Taclonex is a product combining two molecules, calcipotriol and betamethasone dipropionate, that may offer psoriatic patients with an option for maintenance therapy. The efficacy and safety of this combined formulation when used over a 4-week period is well documented...
May 2007: Skin Therapy Letter
https://www.readbyqxmd.com/read/17135738/efficacy-results-of-a-52-week-randomised-double-blind-safety-study-of-a-calcipotriol-betamethasone-dipropionate-two-compound-product-daivobet-dovobet-taclonex-in-the-treatment-of-psoriasis-vulgaris
#17
RANDOMIZED CONTROLLED TRIAL
K Kragballe, J Austad, L Barnes, A Bibby, M de la Brassinne, F Cambazard, C Fleming, H Heikkilä, Z Williams, J Peyri Rey, A Svensson, J Toole, G Wozel
BACKGROUND: The calcipotriol/betamethasone dipropionate two-compound product is safe and effective in the short-term treatment of psoriasis. OBJECTIVE: The primary objective was to investigate the safety of two treatment regimens involving use of the two-compound product over 52 weeks. The efficacy results are presented here. METHODS: Six hundred and thirty-four patients were randomised double-blind to treatment (once daily, when required) with either: 52 weeks of two-compound product (two-compound group), 52 weeks of alternating 4-week periods of two-compound product and calcipotriol (alternating group), or 4 weeks of two-compound product followed by 48 weeks of calcipotriol (calcipotriol group)...
2006: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/16911387/retrospective-assessment-of-pasi-50-and-pasi-75-attainment-with-a-calcipotriol-betamethasone-dipropionate-ointment
#18
RANDOMIZED CONTROLLED TRIAL
Alex V Anstey, Knud Kragballe
BACKGROUND: The US National Psoriasis Foundation recently recommended that PASI 50 and PASI 75 response rates be used in clinical trials to enable comparisons across studies of different psoriasis therapies. To date, these response rates have not been reported for the two-compound ointment containing calcipotriol and betamethasone dipropionate (Daivobet/Dovobet; LEO Pharma, Ballerup, Denmark). Further, in order to compare Daivobet with other therapeutics recently presented to the European regulatory authorities and the FDA, comparison with the biologicals, efalizumab, etanercept and alefacept, were also made...
August 2006: International Journal of Dermatology
https://www.readbyqxmd.com/read/16704648/a-52-week-randomized-safety-study-of-a-calcipotriol-betamethasone-dipropionate-two-compound-product-dovobet-daivobet-taclonex-in-the-treatment-of-psoriasis-vulgaris
#19
RANDOMIZED CONTROLLED TRIAL
K Kragballe, J Austad, L Barnes, A Bibby, M de la Brassinne, F Cambazard, C Fleming, H Heikkilä, D Jolliffe, J Peyri, A Svensson, J Toole, G Wozel
BACKGROUND: The calcipotriol/betamethasone dipropionate two-compound product Dovobet/Daivobet/Taclonex(LEO Pharma A/S, Ballerup, Denmark) has been shown to be safe and effective in the treatment of psoriasis for up to 8 weeks. As psoriasis is a chronic disease, long-term treatment may be required, so there is a need to investigate the safety of its use over a longer period of time. OBJECTIVES: To investigate the safety of two treatment regimens involving use of the two-compound product over 52 weeks in the treatment of patients with psoriasis...
June 2006: British Journal of Dermatology
https://www.readbyqxmd.com/read/16088161/cost-effectiveness-of-once-daily-treatment-with-calcipotriol-betamethasone-dipropionate-followed-by-calcipotriol-alone-compared-with-tacalcitol-in-the-treatment-of-psoriasis-vulgaris
#20
RANDOMIZED CONTROLLED TRIAL
Pascale Peeters, Jean-Paul Ortonne, René Sitbon, Eric Guignard
BACKGROUND: Daivobet is a once-daily treatment of psoriasis vulgaris containing betamethasone dipropionate and calcipotriol in a new ointment vehicle. OBJECTIVE: To assess the cost-effectiveness of once-daily treatment with Daivobet (4 weeks) followed by calcipotriol (4 weeks) compared to tacalcitol (8 weeks). METHODS: Resource utilization was assessed within a double-blind 8-week clinical trial (all treatments for psoriasis, adverse events and concomitant dermatological medication), estimated from the French societal perspective...
2005: Dermatology: International Journal for Clinical and Investigative Dermatology
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