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JOURNAL ARTICLE
Giovanni Adami, Maurizio Rossini, Davide Gatti, Paolo Serpi, Christian Fabrizio, Roberto Lovato
Dual-energy X-ray absorptiometry (DXA) represents the gold standard for measuring bone mineral density (BMD). However, its size and bulkiness limit its use in mass screening. Portable and easily accessible instruments are more suitable for this purpose. We conducted a study to assess the repeatability, sensitivity, accuracy, and validation of a new ultrasound densitometer for the calcaneus (OsteoSys BeeTLe) compared to standard DXA. BMD (g/cm2 ) was measured at the femoral and lumbar spine levels using DXA (Discovery Acclaim (Hologic, Waltham, MA, USA) or Lunar Prodigy (GE Healthcare, Madison, WI, USA) devices)...
March 22, 2024: Scientific Reports
#22
JOURNAL ARTICLE
Hongbin Luo, Jie Wei, Songye Wu, Qunya Zheng, Xinhua Lin, Peng Chen
BACKGROUND: Steroid-induced osteonecrosis of the femoral head (SONFH) is a prevalent and incapacitating condition that affects the hip joint. Unfortunately, early diagnostic and treatment measures are limited. METHODS: Our study employed Tandem Mass Tag (TMT) labeling mass spectrometry (MS)-based quantitative proteome to compare the proteins of femoral head tissues in patients with SONFH with those of patients who sustained femoral neck fracture (FNF). We investigated the level and effects of glucose transporter member 1 (GLUT1) in SONFH patients and MC3T3-E1 cells and examined the function and molecular mechanism of GLUT1 in the context of SONFH using in vivo and in vitro approaches...
March 20, 2024: Bone
#23
Andrew Renshaw, Nneoma Duru, Eric Assid, Gerard K Williams, Misty Suri, Deryk Jones
Background: An osteochondral defect in the hip can be a painful and limiting pathologic process. The damaged joint may progress into premature osteoarthritis, further limiting a patient's functionality. Case Report: A 24-year-old male presented to the clinic with left hip pain. The patient had been involved in a motor vehicle accident 3 years prior to presentation to our clinic. His injury from the high-speed accident required intramedullary rod fixation for a right-sided (contralateral) subtrochanteric femur fracture...
2024: Ochsner Journal
#24
JOURNAL ARTICLE
Rohan R Patel, Timothy A Damron
BACKGROUND: Nonossifying fibroma (NOF) and fibrous cortical defect (FCDs), the most common benign pediatric bone lesions, are usually incidental x-ray findings. Surveillance of characteristic lesions has been recommended to monitor for enlargement and assess fracture risk. However, no accepted fracture risk prediction guidelines exist, so indications for prophylactic surgery are unclear. The study's purposes were to (1) characterize the timing of NOF/FCD-associated fractures, (2) quantify the resources devoted to surveillance, and (3) evaluate the potential for surveillance to prevent pathologic fracture...
March 20, 2024: Journal of Pediatric Orthopedics
#25
JOURNAL ARTICLE
Robert Meertens, Ben Lopez, Ben Crone, Mike Gundry, Emma Metcalfe-Smith, Warren Gibbard, Thomas Jubb, Fay Manning, Paul Scott, Richard McWilliam
Osteoporosis and associated fractures are an increasingly prevalent concern with an ageing population. This study reports testing of IBEX Bone Health (IBEX BH) software, applied following acquisition of forearm radiographs. IBEX Bone Health analyses the radiograph to measure areal bone mineral density (aBMD) at the examination site. A non-randomized cross-sectional study design was performed involving 261 (254 after exclusions) participants (112/142 m/f; mean age 70.8 years (SD+/-9.0); 53 with osteoporosis)...
April 2024: JBMR Plus
#26
JOURNAL ARTICLE
Saima Riaz, Syed Shakil Ur Rehman, Sana Hafeez, Danish Hassan
Osteopenia is a condition characterized by low bone mineral density (BMD) that increases fracture risk, particularly among postmenopausal women (PMW). This study aimed to determine the effects of Kinect-based VRT on BMD and fracture risk in PMW with osteopenia. The study was a prospective, two-arm, parallel-design, randomized controlled trial. The study enrolled 52 participants, 26 randomly assigned to each group. In the experimental group, Kinect-based VRT was provided thrice weekly for 24 weeks for 45 min/session...
March 20, 2024: Scientific Reports
#27
Suhasheni Rajendran, Ze Chen Lee, Chu Ee Seow, Chong Hui Khaw
BACKGROUND: The COVID-19 pandemic has caused major impacts in various aspects of our life. In Malaysia, a Movement Control Order was imposed in March 2020. For almost two years, school going children and adolescents were not able to attend school physically, and their physical activity was confined within their room or house on most days. Case Description . We describe a case of a 14-year-old boy who was previously active in sports and sustained a low trauma fracture at the right neck of the femur following a prolonged period of extreme sedentary life along with poor dietary intake during the COVID-19 pandemic period...
2024: Case Reports in Endocrinology
#28
JOURNAL ARTICLE
Adami Giovanni, Brandi Maria Luisa, Caffarelli Carla, Casciaro Ernesto, Conversano Francesco, Di Paola Marco, Fassio Angelo, Gatti Davide, Giusti Francesca, Gonnelli Stefano, Lombardi Fiorella Anna, Muratore Maurizio, Pisani Paola, Rossini Maurizio
BACKGROUND: Osteoporosis in males is largely under-diagnosed and under-treated, with most of the diagnosis confirmed only after an osteoporotic fracture. Therefore, there is an urgent need for highly accurate and precise technologies capable of identifying osteoporosis earlier, thereby avoiding complications from fragility fractures. AIMS: This study aimed to evaluate the diagnostic accuracy and precision of the non-ionizing technology Radiofrequency Echographic Multi Spectrometry (REMS) for the diagnosis of osteoporosis in a male population in comparison with conventional Dual-energy X-ray Absorptiometry (DXA)...
March 18, 2024: Aging Clinical and Experimental Research
#29
JOURNAL ARTICLE
Li-Tao Shi, Zhen Feng, Cui-Min Zhu
BACKGROUND: This research aims to examine the frequency, age-related distribution, and intensity of preoperative hyponatremia among elderly individuals with hip fractures. This study aims to provide valuable insights into the diagnosis of preoperative hyponatremia in this patient population. METHODS: This research involved the analysis of clinical data obtained from 419 elderly individuals with hip fractures (referred to as the fracture group) and 166 elderly individuals undergoing routine health examinations (designated as the control group)...
March 16, 2024: Journal of Orthopaedic Surgery and Research
#30
JOURNAL ARTICLE
Biochemical characteristics and clinical manifestation of normocalcemic primary hyperparathyroidism.
Inna Yankova, Lora Lilova, Daniela Petrova, Inna Dimitrova, Mariya Stoynova, Alexander Shinkov, Roussanka Kovatcheva
BACKGROUND: Normocalcemic primary hyperparathyroidism (nPHPT) is a condition characterized by persistently high levels of parathyroid hormone (PTH) and normal serum calcium levels in the absence of other causes for secondary hyperparathyroidism. The aim of the present study was to assess the clinical presentation and the biochemical characteristics in patients with nPHPT and to compare them with those in patients with hypercalcemic PHPT (hPHPT). MATERIALS AND METHODS: The study included 316 patients (277 women and 39 men, average age 58...
March 15, 2024: Endocrine
#31
JOURNAL ARTICLE
Neville Jacob, Marios Ghobrial, Martyn Parker
Dislocation of a hip hemiarthroplasty used to treat a hip fracture is a serious complication. The aim of this study was to identify whether a delay in the time from fracture to surgery causes an increase in the rate of post-operative hip dislocation. From a single center, data from intracapsular neck of femur patients treated with hip hemiarthroplasty was collected between October 1986 to August 2021. The time from both fall to surgery and admission to surgery was recorded. Surviving patients were followed up for one year...
February 20, 2024: Injury
#32
JOURNAL ARTICLE
Lishan Cai, Xingyu Lv, Xiang Li, Xuan Wang, Hao Ma, Yoriko Heianza, Lu Qi, Tao Zhou
Osteoporosis is the most common metabolic bone disease in the world, which increases the healthcare service burden. Recent studies have linked higher white matter hyperintensities (WMH) to reduced bone mineral density (BMD), increasing the risk of fractures and falls in older adults. However, limited evidence exists regarding the dose-response relationship between WMH and bone health in a larger and younger population. Our study aimed to examine the association of WMH volume with BMD, incident fractures and falls, with a particular focus on dose-response relationship with varying levels of WMH volume...
February 21, 2024: Journal of Bone and Mineral Research
#33
JOURNAL ARTICLE
Jonathan H Tobias, Maria Nethander, Benjamin G Faber, Sophie V Heppenstall, Raja Ebsim, Tim Cootes, Claudia Lindner, Fiona R Saunders, Jenny S Gregory, Richard M Aspden, Nicholas C Harvey, John P Kemp, Monika Frysz, Claes Ohlsson
Femoral neck width (FNW) derived from dual energy X-ray absorptiometry (DXA) scans may provide a useful adjunct to hip fracture prediction, by providing depth information missing from bone mineral density (BMD) measurements. Therefore, we investigated whether FNW is related to hip fracture risk independently of FN-BMD, using a genetic approach. FNW was derived from points automatically placed on the proximal femur using hip DXA scans from 38,150 individuals (mean age 63.8 years, 48.0% males) in UK Biobank (UKB)...
January 12, 2024: Journal of Bone and Mineral Research
#34
JOURNAL ARTICLE
Xin-Yuan Wang, Xin-Yu Wang, Zhi-Xin Liao, Yue-An Zhao, Chang Wei, Lin-Jing Gong
INTRODUCTION: This study aimed to synthesize existing evidence on the potential association between obstructive sleep apnea (OSA) and low bone mass in adults. METHODS: Electronic searches of four main databases were performed. The inclusion criteria consisted of observational studies investigating the relationship between OSA and bone mass, osteoporosis, fractures, or bone metabolism markers in adult population. Bone mineral density (BMD) and T score of lumbar and femur neck, incidence of osteoporosis and fractures, bone metabolism marker levels were extracted as primary outcomes...
January 2024: Sleep and Biological Rhythms
#35
JOURNAL ARTICLE
Yosuke Sato, Takashi Tagami, Toshio Akimoto, Toru Takiguchi, Yusuke Endo, Takeshi Tsukamoto, Yoshiaki Hara, Shoji Yokobori
We aimed to establish a new method of obtaining femur anteroposterior radiographs from live rats. We used five adult male Sprague-Dawley rats and created a femoral fracture model with an 8 mm segmental fragment. After the surgery, we obtained two femoral anteroposterior radiographs, a novel overhead method, and a traditional craniocaudal view. We obtained the overhead method three times, craniocaudal view once, and anteroposterior radiograph of the isolated femoral bone after euthanasia. We compared the overhead method and craniocaudal view with an isolated femoral anteroposterior view...
March 6, 2024: Scientific Reports
#36
JOURNAL ARTICLE
Deepak Pandiar, P Anbumani, Reshma Poothakulath Krishnan
Non-ossifying fibroma (NOF) of jaw bones are rare. While NOF is the most common benign bone tumor of long bones with pathognomonic radiological features and bear a tendency for self-regression, gnathic NOF appears to be comparatively larger in size and behave more aggressively. A 16 years old female patient reported with painless swelling of the right side of the face of 4 months duration. Radiographic analysis showed a unilocular radiolucent lesion of right angle of the mandible with ill-defined margins, cortical perforation and thinning of inferior border...
February 2024: Indian Journal of Otolaryngology and Head and Neck Surgery
#37
JOURNAL ARTICLE
O Güran, B Gencer
OBJECTIVE: While the proximal femoral nail (PFN) is deemed a successful therapeutic approach for intertrochanteric femoral fractures, medical professionals lack agreement as to the optimal surgical positioning. Our objective was to determine the radiological superiorities of three different surgical positions (supine, lateral decubitus, and traction table). PATIENTS AND METHODS: In this clinical study, 157 prospectively followed-up patients who were operated with PFN for intertrochanteric femur fractures between 2019 and 2022 were analyzed retrospectively...
February 2024: European Review for Medical and Pharmacological Sciences
#38
Hamza R Gomaa, Ali A Buanq, Ahmed M Hazeem, Salma M Daoud, Ali H Almajed
Avascular necrosis (AVN) of the femoral head is a well-documented complication that occurs following femoral neck fractures in both adults and pediatrics. Incidence of AVN following intramedullary nailing (IMN) for femoral shaft fractures is relatively rare. We are reporting an exceptional case of a 28-year-old skeletally mature adult, with no risk factors, who developed stage 3 AVN following trochanteric entry-point IMN for a traumatic femur shaft fracture. Our case contributes to the existing literature by adding to the limited number of reported cases available...
January 2024: Curēus
#39
MULTICENTER STUDY
Ahmed A H H Nasser, Manpreet Sidhu, Rohan Prakash, Ansar Mahmood, Khabab Osman, Govind S Chauhan, Rajpal Nandra, Varun Dewan, Jerome Davidson, Mohammed Al-Azzawi, Christian Smith, Mothana Gawad, Ioannis Palaiologos, Rory Cuthbert, Warran Wignadasan, Daniel Banks, James Archer, Abdulrahman Odeh, Thomas Moores, Muaaz Tahir, Margaret Brooks, Gurdeep Biring, Stevan Jordan, Zain Elahi, Mohammed Shaath, Manoj Veettil, Chiranjit De, Charles Handford, Mohit Bansal, Akshdeep Bawa, Ahmed Mattar, Varun Tandra, Audrina Daadipour, Ahmed Taha, Shafat Gangoo, Sriram Srinivasan, Mandishona Tarisai, Basil Budair, Krishna Subbaraman, Farrukh Khan, Austin Gomindes, Arjun Samuel, Niel Kang, Karan Kapur, Elizabeth Mainwaring, Hannah Bridgwater, Andre Lo, Usman Ahmed, Tahir Khaleeq, Ahmed El-Bakoury, Ramy Rashed, Hazem Hosny, Rathan Yarlagadda, Jonathan Keenan, Ahmed Hamed, Bryan Riemer, Arham Qureshi, Vatsal Gupta, Matthew Waites, Sabri Bleibleh, David Westacott, Jonathan Phillips, Jamie East, Daniel Huntley, Saqib Masud, Yusuf Mirza, Sandeep Mishra, David Dunlop, Mohamed Khalefa, Balasubramanian Balakumar, Mahesh Thibbaiah, Olivia Payton, James Berstock, Krisna Deano, Khaled M Sarraf, Kartik Logishetty, George Lee, Hariharan Subbiah-Ponniah, Nirav Shah, Aakaash Venkatesan, James Cheseldene-Culley, Joseph Ayathamattam, Samantha Tross, Sukhwinder Randhawa, Faisal Mohammed, Ramla Ali, Jonathan Bird, Kursheed Khan, Muhammad A Akhtar, Andrew Brunt, Panagiotis Roupakiotis, Padmanabhan Subramanian, Nelson Bua, Mounir Hakimi, Samer Bitar, Majed Al Najjar, Ajay Radhakrishnan, Charlie Gamble, Andrew James, Catherine Gilmore, Dan Dawson, Rajesh Sofat, Mohamed Antar, Aashish Raghu, Sam Heaton, Waleed Tawfeek, Christerlyn Charles, Henry Burnand, Sean Duffy, Luke Taylor, Laura Magill, Rita Perry, Michala Pettitt, Kelvin Okoth, Thomas Pinkney
AIMS: Periprosthetic fractures (PPFs) around the knee are challenging injuries. This study aims to describe the characteristics of knee PPFs and the impact of patient demographics, fracture types, and management modalities on in-hospital mortality. METHODS: Using a multicentre study design, independent of registry data, we included adult patients sustaining a PPF around a knee arthroplasty between 1 January 2010 and 31 December 2019. Univariate, then multivariable, logistic regression analyses were performed to study the impact of patient, fracture, and treatment on mortality...
February 1, 2024: Bone & Joint Journal
#40
JOURNAL ARTICLE
Haiyang Xing, Ruiqi Zou, Xiongfeng Tang, Min Yi, Zhuoting Xie, Sen You, Jianhua Liu, Quanchao Zhang, Yanguo Qin
We examined the remains of an individual who was unearthed from the Tuchengzi site and was believed to be from the Warring States period in China. The remains exhibited segmental femoral fracture. We aimed to deduce the cause of fracture, medical interventions, healing process, and motion behavior after fracture healing using several techniques, including macroscopic observation, computed tomography (CT), and finite element analysis. Based on the morphology of the long bones, it appeared that the individual was male...
February 28, 2024: Scientific Reports
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